San Beda College COLLEGE OF NURSING P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc.

4131 GENERIC NAME: Cefuroxime Route of Administration: I.V INDICATIONS/ CONTRAINDICATIO NS ADVERSE REACTIO NS TO WATCH OUT FOR Diarrhea/lo ose stools, N&V, abdominal pain. Large doses can cause cerebral irritation and convulsion s; nausea, vomiting, diarrhoea, GI BRAND NAME: Dosage: 750mg DRUG INTERACTIO NS NURSING CONSIDERATIO NS

MODE OF DRUG CLASS ACTION

HEALTH TEACHINGS

Antibiotic Cephalospo rin, second generation

Cefuroxime binds to one or more of the penicillinbinding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Contraindication: Cefuroxime for Injection USP and Dextrose Injection USP is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products. Indications:

1. Use IV route for Probenecid de severe/life creases renal threatening infections such as clearance of septicemia, or in cefuroxime. poor-risk clients, especially Potentially Fatal: Nephrot inpresence of shock. oxicity with aminoglycosid 2. For direct IV, es reconstitute 750 and furosemid mg in 8 mL sterile e. water; give over 3-5 min. For intermittent IV, further dilute in

1. Report lack of response, persistent diarrhea or 5&S of anemia (SOB, dizziness, pale skin, etc.) immediately.

. skin infections. pseudome mbranous colitis. infuse over 30 min.For the treatment of many different types of bacterial infections such as bronchitis. 100 mL of dextrose or saline solution. sinusitis. StevensJohnson syndrome. Potentially Fatal: Ana phylaxis. gonorrhea. nephrotoxi city. ear infections. erythema multiforme. epidermal necrolysis. and urinary tract infection disturbanc es. tonsillitis.

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