Preface
When the time approached for the second edition of the
Hematopathology book, the editors decided for a major revi-
sion in order to make the book more useful to the read-
ers. They decided to create an Atlas of Hematopathology by
increasing the number of the images, whilst keeping the
text concise and to the point. The most important and
unique feature of this book is that it is comprehensive and
multidisciplinary:
1. Comprehensive, because it covers both non-neoplastic hema-
topathology and neoplastic hematopathology in all organs
and tissues.
2. Multidisciplinary, because in addition to demonstra-
tion of conventional histpathology and cytopathology, it
demonstrates results of other important complementary
diagnostic tests, such as immunophenotyping (immunohis-
tochemical stains and flow cytometry), karyotyping, FISH and
DNA/molecular studies.
The explosion of new molecular, cytogenetic, and pro-
teomic techniques applicable to pathology has not ren-
dered histologic examination obsolete, but rather offers
powerful ancillary information to facilitate differential
diagnosis, predict prognostic behavior, and help in the
selection of targeted molecular therapies. With this in
mind, we have constructed most chapters along the gen-
eral format for each disease category to demonstrate
clinical aspects, morphology, laboratory findings, immu-
nohistochemical and flow cytometric results, cytogenetics
and molecular studies, and differential diagnosis.
This book offers important information to practicing
physicians and those in pathology and hematology train-
ing, to help them to improve their diagnostic skills. It also
functions as a valuable referral book for researchers who
work in hematology-related areas. The book consists of 63
chapters. The first 6 chapters are devoted to normal struc-
ture and function of hematopoietic tissues, principles of
immunophenotyping, cytogenetics and molecular genet-
ics, an overview of abnormal bone marrow morphology,
and reactive lymphadenopathies. The remaining chapters
deal with various types of neoplastic and non-neoplastic
hematopoietic disorders. The hematopoietic neoplasms
are classified according to the World Health Organization
(WHO) Classification published in 2008, with minor
modifications.
Faramarz Naeim, M.D.
P. Nagesh Rao, Ph.D.
Sophie X. Song, M.D. Ph.D.
Wayne W. Grody, M.D., Ph.D.
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