Nearly A Century Later, New Findings Support Warburg Theory Of Cancer

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Nearly A Century Later, New Findings Support Warburg Theory Of Just In:
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Cancer Science Video News
ScienceDaily (Jan. 14, 2009) — German scientist Otto H.
Warburg's theory on the origin of cancer earned him the Unraveling Brain Tumors
Nobel Prize in 1931, but the biochemical basis for his Brain tumor researchers have found
theory remained elusive. that brain tumors arise from cancer
stem cells living within tiny protective
His theory that cancer starts from areas formed by blood vessels in
See also: irreversible injury to cellular the. ... > full story
respiration eventually fell out of
Health & Medicine favor amid research pointing to ● Urologists Use Optics, Chemistry to Catch Small
● Brain Tumor genomic mutations as the cause of Tumors
● Cancer uncontrolled cell growth. ● Computer Scientists Simulate Activity Of Ants To
● Lung Cancer Reduce Airline Delays
Seventy-eight years after Warburg
● Skin Cancer
received science's highest honor, ● Acoustic Waves Could Help Put Out Flames in
● Colon Cancer researchers from Boston College Zero-Gravity Environments
● Ovarian Cancer and Washington University School
of Medicine report new evidence in ● more science videos
Reference support of the original Warburg
● Metastasis Theory of Cancer.
● Tumor
A descendant of German
● Heat shock protein
aristocrats, World War I cavalry
● Health benefits of
officer and pioneering biochemist,
tea Warburg first proposed in 1924 that
the prime cause of cancer was injury
to a cell caused by impairment to a
cell's power plant – or energy
metabolism – found in its
mitochondria.
In contrast to healthy cells, which generate energy by the
oxidative breakdown of a simple acid within the mitochondria,
tumors and cancer cells generate energy through the non-
oxidative breakdown of glucose, a process called glycolysis.
Indeed, glycolysis is the biochemical hallmark of most, if not
all, types of cancers. Because of this difference between These three-dimensional illustrations show the
healthy cells and cancer cells, Warburg argued, cancer should relationship of cardiolipin abnormalities to electron
be interpreted as a type of mitochondrial disease. transport chain activities in the cells of mouse brain
In the years that followed, Warburg's theory inspired tumors studied by researchers from Boston College Breaking News ... from NewsDaily.com
controversy and debate as researchers instead found that and Washington University School of Medicine.
genetic mutations within cells caused malignant transformation The graphs show the position of the tumors in
and uncontrolled cell growth. Many researchers argued relation to their host strain in three enzyme
complexes. The team reported in the Journal of ● Ancient bird dung
Warburg's findings really identified the effects, and not the gives clues to pre-
causes, of cancer since no mitochondrial defects could be Lipid Research new findings that support the
found that were consistently associated with malignant Warburg Theory of Cancer. The new research human New Zealand
transformation in cancers. contends that cancer could arise from genomic ● Feeling pretty?
mutations, environmental insults, or from
epigenetic (gene-environmental) abnormalities, any Hormones may lead
Boston College biologists and colleagues at Washington
University School of Medicine found new evidence to support of which could damage cardiolipin and ultimately to more...
Warburg's theory by examining mitochondrial lipids in a produce irreversible injury to cellular respiration. ● Smoking when
diverse group of mouse brain tumors, specifically a complex (Credit: The Journal of Lipid Research) pregnant affects
lipid known as cardiolipin (CL). They reported their findings in thyroid for both:
the December edition of the Journal of Lipid Research.
study
Abnormalities in cardiolipin can impair mitochondrial function Related Stories
http://www.sciencedaily.com/releases/2009/01/090112093334.htm (1 of 3)1/14/2009 12:54:51 PM
Nearly A Century Later, New Findings Support Warburg Theory Of Cancer

and energy production. Boston College doctoral student ● As humans hunt,

Michael Kiebish and Professors Thomas N. Seyfried and Copper May Play Role In 'Starving' Cancer To their prey gets
Jeffrey Chuang compared the cardiolipin content in normal Standstill (Feb. 12, 2004) — Starving a cancerous smaller: study
mouse brain mitochondria with CL content in several types of
brain tumors taken from mice. Bioinformatic models were used tumor of its blood supply might stop its growth ● Extinct Tasmanian
to compare the lipid characteristics of the normal and the while other treatments aim to kill it. "Nutrient "tiger" DNA has
tumor mitochondria samples. Major abnormalities in cardiolipin depletion" is how Dr. Ed Harris, Texas A and M clues to demise
content or composition were present in all types of tumors and University biochemist, ... > read more
closely associated with significant reductions in energy- ● more science news
generating activities. Cloning Embryos From Cancer Cells (June 4,
2003) — Nuclei removed from mouse brain tumor In Other News ...
The findings were consistent with the pivotal role of cardiolipin cells and transplanted into mouse eggs whose own
in maintaining the structural integrity of a cell's inner nuclei have been removed, give rise to cloned ● Nortel seeks
mitochondrial membrane, responsible for energy production. embryos with normal tissues, even though the bankruptcy
The results suggest that cardiolipin abnormalities "can underlie mutations causing the ... > read more protection, shares
the irreversible respiratory injury in tumors and link plunge
mitochondrial lipid defects to the Warburg theory of cancer," New Evidence Supports Century-old Theory Of
according to the co-authors. Cancer Spread (Dec. 12, 2005) — A Yale School ● Senate panel delays
of Medicine study in the December issue of Lancet Geithner hearing to
These findings can provide insight into new cancer therapies Jan. 21
that could exploit the bioenergetic defects of tumor cells Oncology challenges mainstream oncology
without harming normal body cells. researchers to consider tumor cell hybridization ● Chrysler rules out
with white blood cells as a major reason that ... sale of individual
Seyfried, Chuang and Kiebish were joined by co-authors > read more
brands
Xianlin Han and Hua Cheng from the Washington University
School of Medicine, Department of Internal Medicine, in St. Mathematics Reveals Genetic Pattern Of Tumor ● Palestinian death
Louis. Growth (June 22, 2007) — Using mathematical toll in Gaza tops
theory, scientists have shed light on one of 1,000: ministry
cancer's most troubling puzzles -- how cancer cells
Journal reference: can alter their own genetic makeup to accelerate ● Retail sales dive as
tumor growth. The discovery shows ... > read more holiday spending
1. Kiebish et al. Cardiolipin and electron transport chain slumps
abnormalities in mouse brain tumor mitochondria: Autism's Fogged-up Mirror (Jan. 3, 2005) —
lipidomic evidence supporting the Warburg theory of ● Worries over
People with autism experience less activity in the
cancer. The Journal of Lipid Research, 2008; 49 (12): 2545 brain neurons that specifically trigger human Citigroup mount
DOI: 10.1194/jlr.M800319-JLR200 empathy, according to a new study by UdeM ● Rights group urges
researcher Hugo Théoret. The professor in the ... U.S. to counter
Adapted from materials provided by Boston College, via > read more
EurekAlert!, a service of AAAS. "spoiler" states
● Obama scrambles on Geithner, bailout concerns
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Nearly A Century Later, New Findings Support Warburg Theory Of Cancer

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