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The Physician's Guide to Laboratory Test Selection and Interpretation

Tumor Markers
Clinical Background
Tumor and genetic markers may be useful in the diagnosis, treatment, monitoring and prognostication
®
of specific tumors. Available markers include those in the following table (most are available at ARUP
Laboratories); for recommendations, see the Diagnosis tab. The information that follows is general in nature;
for specific information regarding use and interpretation of various markers and tests, consultation with a
pathologist is highly advised.
Tumor Markers
Tumor markers - #
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

1p/19q, d(1;19) Oligodendroglioma T

5-HIAA Carcinoid U

11q23 (MLL) Acute lymphocytic B,T B


leukemia (ALL)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - A
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

AccuDx FDP Bladder U

ACTH Neuroendocrine T B

AFP Hepatocellular (HCC), T B


germ cell, ovarian, GI
tract

AFP-L3% HCC B

ALK rearrangement Lymphoma, non-small T T 1


T
1
cell lung (NSCLC)

Alpha subunit Neuroendocrine T B


(pituitary)

AML1/ETO t(8;21) Acute myeloid B,T T


leukemia (AML)

API2-MLT1 t(11;18) Lymphoma, mucosa- T


associated lymphoid
tissue (MALT)

APC Colorectal T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - B
Marker Methodology
Malignancy
Molecular FISH IHC Other

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Stain

b72.3 Mesothelioma, lung, T


breast, ovarian, colon

BF-1 Lymphoma T

BG-8 (Lewis Y) Breast, lung T B

BOB-1 Lymphoma T

BRAF V600E Lynch syndrome, T


melanoma, thyroid

®
BTA stat (Bladder Bladder U
tumor antigen)

BTA TRAK
® Bladder U

BCR/ABL1 Chronic myelogenous B B,T T


t(9;22)(q34;q11.2) leukemia (CML), ALL-
L1/L2 subtypes

BCL-6 (CD19) Lymphoma, B-ALL T T B

bcl-1/JH t(11;14) Lymphoma B T T T

bcl-2/JH t(14;18) Lymphoma B T T T

β-hCG Trophoblastic, germ T B


cell, lung, melanoma,
gastrointestinal,
ovarian

BRCA1, BRCA2 Breast B T

BRST II (GCDFP-15) Breast T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - C
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

c-Myc (MYC Lymphoma (Burkitt B,T T T


rearrangements lymphoma), B-ALL
[t(8;14)])

CA 125 Ovarian, cervical, T B


uterine

CA 15-3 Breast, pancreatic, B


lung, ovarian

CA 19-9 Pancreatic, gastric, F


colon, breast, biliary
tract

CA 27.29 Breast B

CA 72-4 Gastric B

C-peptide Neuroendocrine B

Calcitonin T B

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Neuroendocrine,
medullary thyroid
carcinoma (MTC)

Calcium Parathyroid B

Calretinin Mesothelioma, lung T

Catecholamines Pheochromocytoma, B,U


neuroblastoma

CD2 T-ALL, lymphoma T

CD3 T-ALL, CLL, lymphoma T B

CD4 Lymphoma T

CD5 CLL, lymphoma T B

CD7 Lymphoma T

CD8 Lymphoma, bladder T

CD10 Lymphoma, ALL T B

CD14 (MY4) Leukemia/lymphoma T B,T

CD15 (Leu M1) Lymphoma/leukemia T B,T

CD19 (BCL-6) Lymphoma, B-ALL T T B

CD20 (CALLA) B-ALL, CLL, lymphoma T B,T

CD21 Lymphoma T

CD23 CLL, lymphoma T B

CD30 (Ki-1) Breast T

CD33 AML T B,T

CD38 CLL T B

CD45 Lymphoma (DLBL) T

CD52 Lymphoma T

CD56 (NCAM) Merkel cell carcinoma T B,T


(MCC), leukemia/
lymphoma

CD57 Leukemia/lymphoma T

CD64 Leukemia/lymphoma T B,T

CD68 (KP1) Glioma T

CD79A B-ALL T

CD95 (APO-1/Fas) ALL T

CD99 ALL, Ewing sarcoma, T B


osteosarcoma

CD117 (c-KIT )
1 Gastrointestinal T
1
T
1 B
1
stromal tumor (GIST) ,
leukemia/lymphoma,
melanoma

CD138 (Syndecon-1) Lymphoma T

CD173 (H2) Breast T B

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CD174 (FUT3) Breast, colorectal, T B


gastric, lung

CDX2 Colorectal, ovarian, T


pancreatic,
neuroendocrine
(thyroid, parathyroid),
gastrointestinal
adenocarcinomas,
lung, thyroid

CEA (carcinoembryonic Colorectal, lung T B,F


1

antigen) polyclonal/ (including NSCLC),


monoclonal breast, ovarian, uterine;
1
MTC, pancreatic

CEACAM1 (17) Pancreatic B

CEBPA AML B,T

Chromogranin A Neuroendocrine, T B
neuroblastoma, small
cell lung (SCLC)

CHOP rearrangement Liposarcoma T

CK 5,6 Mesothelioma T

CK 7 Colorectal, NSCLC T

CK 8,18 (CAM 5.2) Carcinoid T

CK 19 fragment NSCLC, head and neck B


(CYFRA 21-1) (squamous cell)

CK 20 Bladder, colorectal, T
lung

c-KIT (CD117) Gastrointestinal T


1
T
1 B
1
stromal tumor (GIST) ,
leukemia/lymphoma,
melanoma

Cyclin D1, SP4 t(11;14) Lymphoma, CLL T T

Cytokeratin (CK) [pan Neuroendocrine T


cytokeratin AE1,3]

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - D
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

DCP (des-gamma- HCC B


carboxy prothrombin)

DEK-NUP214 AML B
t(6;9)(p23;q34)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

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Tumor markers - E
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

E2A-PBX1 B-ALL B,T T


t(1;19)(q23;p13.3)
(TCF3-PBX1)

EBV-LMP1 Burkitt lymphoma, T


lymphoma/leukemia,
head and neck

EBV-EBER Lymphoma T

E-Cadherin Gastric (familial) T

EGFR Lung, head and neck, T T


colorectal, brain

EML4-ALK NSCLC T

Estrogen, progesterone Breast T


receptors

ETV6-RUNX1 ALL, sarcomas T


(TEL-AML1)
t(12;21)(p13;q22)

EWSR-E1AF Ewing sarcoma T T T


t(2;22)(q33;12)
EWR1S-ERG
t(21;22)(q22;q12)
EWS-ETV1
t(7;22)(p22;q12)
EWS-ETV4
t(12;22)(q21;q12)
EWS-FLI-1
t(11;22)(q24;q12)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - F
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

FLT3 AML B,T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - G
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

Gastrin Gastrinoma, carcinoid T B

Glucagon Glucagonoma T B

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Growth hormone Neuroendocrine T B

GHRH (growth Neuroendocrine B


hormone releasing (pituitary)
hormone)

Granzyme B Lymphoma T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - H
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

βhCG Trophoblastic, germ T B


cell, lung, melanoma,
gastrointestinal,
ovarian

Hercept/HER2 Breast T T T B
HER2/neu

KSHV (HHV8) Kaposi sarcoma T T

HBME-1 (mesothelial Mesothelioma T


cell)

HMB45 (gp100) Melanoma, ovarian T T

HE4 Ovarian B

Helicobacter pylori Gastric (risk factor) T

HPV (hybrid capture on Endocervical, head and T


1
T
2

1
cervical brush ; ISH on neck
2
tissue )

HRPT2 Parathyroid, primary T B


hyperparathyroidism

HTLV Lymphoma T

HVA Neuroblastoma U

Hyperdiploidy (+4, +10, ALL T


+17)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - I
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

IGF-1 Neuroendocrine B

IGH/BCL2 Lymphoma (follicular B,T


cell)

IGH-CCND1 Lymphoma (mantle B B,T


cell), multiple myeloma

IGH rearrangement ALL T

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IL3/IGH B-ALL B,T T


t(5;14)(q31;q32)


ImmunoCyt /uCyt+
™ Bladder U

Insulin Insulinoma T B

inv(3), t(3;3) EVI1 Leukemia B,T T

inv(16) or t(16;16) AML B,T T


CBFβ/MYH11

IGH/myc CEPA t(8;14) Burkitt lymphoma T

IgVH mutation CLL B,T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - J
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

JAK2 Myeloproliferative B,T


neoplasms

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - K
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

KIT (D816V) GIST, testicular, B,T,F


1 B
1
melanoma

Ki-67 (MIB-1) Prostate, breast, T


neuroendocrine,
bladder, brain,
lymphoma

KRAS mutation Colorectal, breast, T


detection pancreatic

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - L
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

LH/FSH Neuroendocrine T B
(pituitary)

LD Germ cell, skin B

LSA (lipid-associated Breast, gastrointestinal, B


sialic acid) lung, leukemia,
lymphoma, melanoma,
ovarian

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B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - M
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

MDM2 Liposarcoma, glioma T

Melan A Melanoma T

MEN1, MEN2 Neuroendocrine, B


parathyroid

Mesomark
® Mesothelioma B

Metanephrines Pheochromocytoma B,U

Microsatellite instability Colorectal B,T B,T T


(MSI)

MLH1, MSH2, MSH6, Colorectal, Lynch B,T T


PMS2 syndrome

MLL-AF4 t(4;11) Infant leukemia B,T

MLLT3-MLL t(9;11) AML, ALL B,T T

MPO Breast T
(myeloperoxidase)

Muc-1, Muc-2, Muc-4 Pancreatic, thyroid, T B


biliary

MUC-5AC glycoprotein Pancreatic, T


cholangiocarcinoma,
gastric

MUM1/IRF4 B-cell lymphoma T


(DLBL)

Myo D-1, myogenin, Rhabdomyosarcoma T


myoglobin, myosin

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - N
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

Neurofilament (68kDa) Brain, lung T

NPM1 AML B,T

NMP22
® Bladder U

N-myc Neuroblastoma T

NPM-ALK/NPM1 (p80) Lymphoma (anaplastic T


large cell lymphoma)

NRAS Colorectal, Lynch T T


syndrome, melanoma

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NSE Neuroblastoma, SCLC, T B


neuroendocrine

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - O
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

Oct-2 Lymphomas, breast T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - P
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

PAM50 Breast T

p16 Bladder T

p21 (Cip1/Waf1) Bladder T

p27 (Kip1) Bladder, breast, colon, T


stomach, lung, pituitary

p53 Breast (deletions occur T T


across most cancers),
bladder

Pancreatic polypeptide Neuroendocrine, T B


carcinoid

Philadelphia AML, CML B,T T


chromosome t(9;22)

PTH (parathyroid Neuroendocrine, T B


hormone) parathyroid

PTH-related peptide Neuroendocrine, B


parathyroid

PAX3-FKHR Rhabdomyosarcoma T
t(2;13)(q35;q14)
PAX7-FKHR
t(1;13)(p36;q14)

PAX3-FOXO4 t(x;2) Sarcoma T

PAX-5 Lymphoma, ALL T T

PCA3 Prostate B,U

PDGFRβ, PDGFRα GIST, T T


rearrangements, myeloproliferative
FGFR1, CBFB neoplasms (MPN)

PGP 9.5 Carcinoid, nerve- T


sheath tumor

PIK3CA T

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Breast, brain, HCC,


colon, ovarian,
prostate, leukemia

PLAP Seminoma, T
germinoma, ovarian

PML-RARα t(15;17) AML (promyelocytic) T

Proinsulin Insulinoma T B

Prolactin Neuroendocrine T B
(pituitary)

PSA Prostate T B

PTH Parathyroid B

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - R
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

RB-1 Bladder T

RET (MEN2a ,
1
Neuroendocrine ,
1 B
2 1 2
MEN2b ) parathyroid , MTC

RUNX1-RUNX1T1 AML, M2 subtype B,T T


(AML-ETO)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - S
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

S-100, S-100B Melanoma T B

SCC Ag (squamous Head and neck, B


cell carcinoma antigen) NSCLC

SKp2 Breast T

SMAD4 Colorectal B

Serotonin Carcinoid B

Somatostatin Somatostatinoma T B

Survivin Bladder T

Synaptophysin Neuroendocrine T

SYT-SSX1, STY-SSX2 Synovial sarcoma T T

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - T
Marker Methodology

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Malignancy Molecular FISH IHC Other


Stain

TA90-IC Melanoma T B

t(15;17), t(8;21), AML B,T T


t(16;16)

TCRA, TCRB T-ALL B T

TdT ALL T

Thyroglobulin Neuroendocrine T T B,F


(thyroid, parathyroid),
thyroid (well-
differentiated)

TIA-1 Lymphoma T

TSH Neuroendocrine T B
(pituitary), thyroid

TTF-1 (thyroid Thyroid, mesothelioma, T


transcription factor) sarcoma,
adenocarcinoma,
neuroendocrine

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - U
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

UGT1A1 Colorectal B

uPA/PAI-1 Breast T

™ 1 2 1
UroVysion Bladder , pancreatic U
(bladder cancer, T
2

pancreatobiliary FISH)

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - V
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

Villin Adenocarcinoma T
(pancreatic,
gastrointestinal)

VIP Vasoactive intestinal T B


peptide tumor
(VIPoma)

VMA Neuroblastoma U

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - W

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Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

WT-1 (Wilms tumor 1) Ewing sarcoma, T


myelodysplastic
syndrome
(MDS), leukemia,
mesothelioma,
sarcoma,
adenocarcinoma

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Tumor markers - Z
Marker Methodology
Malignancy
Molecular FISH IHC Other
Stain

ZAP-70 CLL T B

B = blood (serum, plasma or whole), T = tissue (includes bone marrow), U = urine, F = fluid

Diagnosis
Tumor Markers and Genetic Markers – Use for Specific Malignancy
The following information is from multiple guideline sources as recommendations for use of tumor markers
and genetic markers.
Gastrointestinal
Tumor Type Marker Recommended Use Recommending
Organizations*
Hepatic AFP Monitoring ACS, NCCN, ESMO,
NACB
Early detection in high-risk ACS, NCCN, ESMO,
patients NACB
AFP-L3% Monitoring, early detection NACB
in high-risk patients,
prognosis
DCP Monitoring, early detection NACB
in high-risk patients,
prognosis
Gastric No markers with good None available NACB
evidence
Helicobacter pylori Environmental risk factor NCCN
E-Cadherin mutations Risk factor in hereditary NCCN
forms
Pancreatic CA19-9 Monitoring NCCN, ESMO, NACB
(ductal adenocarcinoma) Diagnosis NCCN, NACB
Colorectal CEA Monitoring ASCO, NACB, ESMO,
NCCN

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Monitoring advanced ASCO, NACB


disease
Prognosis ASCO, ACS, ESMO,
NCCN, NACB (if used
with other prognostic
features)
KRAS mutation Predict response to EGFR NCCN, ASCO
inhibitors, prognosis
BRAF V600E Lynch syndrome risk NACB
assessment
MSI/HNPCC (molecular Colorectal and NCCN, NACB
and/or IHC) Lynch syndrome risk
assessment
MLH1, MSH2, MSH6, Lynch syndrome risk ESMO, NCCN, NACB
PMS2 assessment
ACS = American Cancer Society, NCCN = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology,
ASCO = American Society of Clinical Oncology, NACB = National Academy of Clinical Biochemistry
*Organization also searched: American Gastroenterological Association

Neuroendocrine
Tumor Type Marker Recommended Use Recommending
Organizations
All neuroendocrine tumors Chromogranin A (serum, Diagnosis NCCN, ESMO, NACB
IHC) Recurrence NACB
Monitoring NACB
Synaptophysin (serum, Diagnosis NCCN
IHC)
Prolactin (serum, IHC) Diagnosis NCCN
CK (Cytokeratin) (serum) Diagnosis NCCN
Ki-67 (MIB-1) (IHC) Diagnosis NCCN
Carcinoid 5-HIAA (urine) Diagnosis NCCN, ESMO, NACB
Monitoring for specific NCCN, ESMO, NACB
tumor
Serotonin (serum) Diagnosis NACB
Chromogranin A (serum, Diagnosis and monitoring NCCN
IHC)
Gastrin (serum, IHC) Diagnosis and monitoring NCCN
Pancreatic polypeptide Diagnosis and monitoring NCCN
(serum, IHC)
Gastrinoma Gastrin (serum, IHC) Diagnosis and monitoring NCCN, ESMO, NACB
Glucagonoma Glucagon (serum, IHC) Diagnosis and monitoring NCCN, ESMO, NACB
Pheochromocytoma Metanephrines (plasma, Diagnosis and monitoring NCCN, ESMO, NACB
urine)
Catecholamines (urine) Diagnosis and monitoring NCCN, ESMO, NACB

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Insulinoma Proinsulin (serum, IHC) Diagnosis and monitoring NCCN, ESMO, NACB
Insulin (serum, IHC) Diagnosis and monitoring NCCN
C-peptide (serum, IHC) Diagnosis and monitoring NCCN
Pituitary Growth hormone (serum, Diagnosis and monitoring NCCN, ESMO, NACB
IHC)
IGF-1 (serum) Diagnosis and monitoring NCCN
Prolactin (serum, IHC) Diagnosis and monitoring NCCN
LH/FSH (serum, IHC) Diagnosis and monitoring NCCN
TSH (serum, IHC) Diagnosis and monitoring NCCN
Alpha subunit (serum, Diagnosis and monitoring NCCN
IHC)
ACTH (serum, IHC) Diagnosis and monitoring NCCN
VIPoma VIP (serum, IHC) Diagnosis and monitoring NCCN, ESMO, NACB
Pancreatic Pancreatic polypeptide Diagnosis and monitoring NCCN, ESMO, NACB
neuroendocrine (serum, IHC)
carcinoma Calcitonin (serum, IHC) Diagnosis and monitoring NCCN
PTH-related peptide Diagnosis and monitoring NCCN
(serum)
PTH (IHC) Diagnosis and monitoring NCCN
Somatostatin (serum, Diagnosis and monitoring NCCN
IHC)
NCCN = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical
Biochemistry

Lung
Tumor Type Marker Recommended Use Recommending
Organizations*
Small cell NSE (serum, IHC) Monitoring ACS, NACB
(SCLC) Prognosis NACB
Chromogranin A Prognosis NACB
Non-small cell CEA, SCC Ag Monitoring, prognosis, NACB, ASCO
(NSCLC) detecting relapse
CK19 fragment Prognosis ASCO
(CYFRA 21-1),
Mesothelioma Soluble mesothelin related Monitoring IMIG, NACB, NCCN
®
peptides (Mesomark )
CK 5,6 Diagnosis NCCN
CEA Diagnosis NCCN
b72.3 Diagnosis NCCN
WT-1 Diagnosis NCCN
TTF-1 Diagnosis NCCN

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Calretinin Diagnosis NCCN


ACS = American Cancer Society, ASCO = American Society of Clinical Oncology, IMIG = International Mesothelioma Interest Group,
NACB = National Academy of Clinical Biochemistry, NCCN = National Comprehensive Cancer Network
*Organizations also searched: American Thoracic Society (ATS), British Thoracic Society (BTS), American College of Chest Surgeons
(ACCP)

Female gynecologic/genitourinary
Tumor Type Marker Recommended Use Recommending
Organizations
Breast Estrogen, progesterone Predict hormone response ASCO, ESMO, NCCN,
receptor (tissue) NACB
Prognosis ASCO (do not use alone),
NCCN, NACB (do not use
alone), ACS
b72.3 Diagnosis NCCN
HER, HER2, HER-2/neu Predict response to ASCO, ESMO, ACS,
(tissue) Herceptin NCCN, NACB
Prognosis NCCN, NACB
Predict response to ASCO, NCCN, NACB
anthracyclines
uPA/PAI-1 (tissue) Prognosis ASCO, ACS, NACB
CA 15-3, CA 27-29 Monitoring advanced ASCO, ESMO, NACB,
disease ACS
CEA Monitoring advanced ASCO, NACB
disease
BRCA1, BRCA2 Identifying high-risk ASCO, NCCN, NACB
patients
HER-2/neu (serum) Monitoring, prognosis NACB
p53 Prognosis NACB
Cervical HPV Risk assessment NCCN, NACB
SCC Ag Monitoring NACB
Ovarian CA 125 Monitoring ESMO, NACB, NCCN
Differential diagnosis is NACB, NCCN
suspicious pelvic mass
Detection of recurrence ESMO, NACB, NCCN
Prognosis ESMO, NACB
βhCG Diagnosis, recurrence NCCN
Gestational trophoblastic βhCG Monitoring ACS, NACB, NCCN
Diagnosis ACS, NACB, NCCN
Bladder BTA stat ,
® Monitoring, early detection ACS, NACB, NCCN
®
BTA TRAK ,
®
NMP22 ,
™, ™
UroVysion ImmunoCyt

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ASCO = American Society of Clinical Oncology, ESMO = European Society of Medical Oncology, NCCN = National Comprehensive
Cancer Network, NACB = National Academy of Clinical Biochemistry, ACS = American Cancer Society

Male Genitourinary
Tumor Type Marker Recommended Use Recommending
Organizations*
Prostate PSA Screening ACS, AUA, EAU, ESMO,
NACB, NCCN
Staging and prognosis AUA, EAU, ESMO,
NCCN, NACB
Monitoring AUA, EAU, ESMO,
NCCN, NACB
Follow-up and negative NCCN, NACB
biopsy
PCA3 Screening NACB
Bladder BTA stat ,
® Monitoring, diagnosis ACS, NACB, NCCN
®
BTA TRAK ,
®
NMP22 ,

UroVysion ,

ImmunoCyt
Germ cell (testicular) βhCG and AFP Diagnosis and ASCO, EAU, ESMO,
differential diagnosis of NACB, NCCN
nonseminomatous germ
cell cancer of the testes
Staging and prognosis ASCO, EAU, ESMO,
NACB, NCCN
Monitoring ASCO, EAU, ESMO,
NACB, NCCN
Detecting recurrence ASCO, EAU, ESMO,
NACB, NCCN
LD Diagnosis ASCO, EAU, ESMO,
NACB, NCCN
Staging and prognosis ASCO, EAU, ESMO,
NACB, NCCN
Monitoring ASCO, EAU, ESMO,
NACB, NCCN
Detecting recurrence ASCO, EAU, ESMO,
NACB, NCCN
ACS = American Cancer Society, ASCO = American Society of Clinical Oncology, AUA = American Urological Association, EAU =
European Association of Urologists, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical Biochemistry,
NCCN = National Comprehensive Cancer Network

Brain

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Tumor Type Marker Recommended Use Recommending


Organizations
Oligodendroglioma 1p/19q Deletion by FISH Diagnosis NACB
NACB = National Academy of Clinical Biochemistry

Soft Tissue/Sarcomas
Tumor Type Marker Recommended Use Recommending
Organizations
Ewing sarcoma EWSR1 – Ewing sarcoma Diagnosis ESMO, NACB, NCCN
by RT-PCR
EWSR1 rearrangement by Diagnosis NACB, NCCN
FISH
Synovial SYT, SYT-SSX Diagnosis NACB, NCCN
SYT rearrangement by Diagnosis NACB, NCCN
FISH
Rhabdomyosarcoma PAX-FKHR Diagnosis NACB, NCCN
Kaposi sarcoma HHV8 Diagnosis NACB, NCCN
ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical Biochemistry, NCCN = National Comprehensive
Cancer Network

Lymphoma
Tumor Type Marker Recommended Use Recommending
Organizations
B-cell and T/NK-cell IGH/BCL2 Diagnosis and NCCN, NACB
differentiation of
lymphomas
IGH/CCND1 Diagnosis of mantle cell NCCN, NACB
(MCL) subtype
API2-MLT1 t(11;18) Diagnosis of a subset of NCCN, ESMO, NACB
MALT lymphomas
ALK rearrangements Diagnosis and NCCN, NACB
differentiation
c-Myc (MYC Diagnosis and NCCN
rearrangements [t(8;14)]) differentiation of Burkitt
lymphoma
CD2, CD3, CD4, CD5, Diagnosis and NCCN, NACB
CD7, CD8, CD10, CD14, differentiation
CD15, CD19 (BCL-6),
CD20, CD21, CD23,
CD33, CD45 (LCA),
CD52, CD56, CD57,
CD64, CD79a, CD117 (c-
KIT), CD138
Cyclin D1, SP4 Diagnosis of MCL and NCCN
t(11;14) multiple myeloma

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EBV-LMP1, EBV-EBER Diagnosis and NCCN


differentiation
Granzyme B Diagnosis NCCN
Ki-67 (MIB-1) Diagnosis NCCN
HTLV Diagnosis and NCCN
differentiation
PAX-5 Diagnosis and NCCN
differentiation
TIA-1 Diagnosis and NCCN
differentiation
MUM1/IRAF4 Diagnosis and NCCN
differentiation
NCCN = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical
Biochemistry

Leukemia
Tumor Type Marker Recommended Use Recommending
Organizations
ALL BCR/ABL1 Diagnosis, prognosis, NACB
monitoring
c-Myc (MYC Diagnosis and NCCN
rearrangements [t(8;14)]) differentiation
ETV6/RUNX1(TEL/AML1) Diagnosis, prognosis, NACB
t(12;21)(p13;q22) monitoring
E2A/PBX1 Diagnosis, prognosis, NACB
t(1;19)(q23;p13.3) monitoring
(TCF3-PBX1)
Hyperdiploidy (+4, +10, Diagnosis, prognosis, NACB
+17) monitoring
MLL rearrangement Diagnosis, prognosis, NACB
monitoring
IGH rearrangement Diagnosis, prognosis, NACB, NCCN
monitoring
AML RUNX1/RUNX1T1 t(8;21) Diagnosis of ESMO, NACB
prognostically important
genetic subtype
FLT3-ITD Prognosis ESMO, NACB
Philadelphia Diagnosis and prognosis NCCN
chromosome t(9;22)
inv(16) or t(16;16) of Diagnosis and prognosis ESMO, NACB, NCCN,
CBFβ/MYH11 WHO
AML1/ETO t(8;21) Diagnosis and prognosis NCCN, WHO
MLLT3-MLL t(9;11) Prognosis NCCN
c-KIT (CD117) Prognosis NCCN

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NPM1 Prognosis NCCN


CEBPA Prognosis NCCN
inv(3), t(3;3) EVI1 Prognosis NCCN
DEK/NUP214 Prognosis NCCN
t(6;9)(p23;q34)
PML/RARα , t(15;17) Diagnosis ESMO, NACB, NCCN
11q23 (MLL) Prognosis ESMO, NACB, NCCN
CLL ZAP-70 Diagnosis NCCN, NACB, ESMO
Prognosis ESMO, NACB
IgVH mutation Prognosis NCCN, ESMO, NACB
CML BCR/ABL1 Diagnosis ESMO, NACB, NCCN
Prognosis NACB, NCCN
Monitoring ESMO, NACB
Philadelphia Diagnosis and prognosis NCCN
chromosome t(9;22)
ESMO = European Society of Medical Oncology, NCCN = National Comprehensive Cancer Network, NACB = National Academy of Clinical
Biochemistry, WHO = World Health Organization

Myeloproliferative Neoplasms
Tumor Type Marker Recommended Use Recommending
Organizations
Myeloproliferative JAK2 Diagnosis NACB
Myeloproliferative with PDGFRα, PDGFRβ and Diagnosis NACB, WHO
associated eosinophilia FGFR1 rearrangements
by FISH
NACB = National Academy of Clinical Biochemistry, WHO = World Health Organization

Childhood Tumors
Tumor Type Marker Recommended Use Recommending
Organizations
Neuroblastoma NSE Prognosis NACB
N-myc Prognosis NACB
HVA, VMA, Diagnosis, monitoring NACB
catecholamines
Childhood leukemia MLL-AF4 rearrangement Diagnosis NACB
BCR/ABL1 Diagnosis, prognosis, NACB, NCCN
monitoring
ETV6/RUNX1(TEL/AML1) Diagnosis, prognosis, NACB, ASCO
t(12;21)(p13;q22) monitoring
Hyperdiploidy (+4, +10, Diagnosis, prognosis, NACB
+17) monitoring
MLL-AF4, t(4;11) Diagnosis, prognosis, NACB
monitoring

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ASCO = American Society of Clinical Oncology, NACB = National Academy of Clinical Biochemistry, NCCN = National Comprehensive
Cancer Network

Skin
Tumor Type Marker Recommended Use Recommending
Organizations
Melanoma TA90-IC Monitoring, prognosis ACS, NACB
S-100, HMB45 (gp100) Diagnosis, usually used in ACS, NACB
combination
S-100B (serum) Monitoring, prognosis ACS, NACB
c-Kit Response to therapy ACS
ACS = American Cancer Society, NACB = National Academy of Clinical Biochemistry

Head and Neck


Tumor Type Marker Recommended Use Recommending
Organizations
Squamous cell cancers SCC Ag Monitoring NACB
CK 19 fragment (CYFRA Prognosis ASCO
21-1)
HPV Risk assessment NACB
Burkitt lymphoma EBV-LMP1 Diagnosis NACB, NCCN
ASCO = American Society of Clinical Oncology, NACB = National Academy of Clinical Biochemistry, NCCN = National Comprehensive
Cancer Network

Thyroid/Parathyroid
Tumor Type Marker Recommended Use Recommending
Organizations
Well-differentiated BRAF V600E (tissue) Diagnosis NACB
BRAF V600E (serum) Prognosis NACB
Thyroglobulin (serum) Diagnosis, monitoring NCCN, AACE, NACB
Thyroglobulin (IHC) Diagnosis NACB
Medullary thyroid Calcitonin Monitoring, diagnosis NCCN, AACE, NACB
carcinoma CEA Diagnosis, monitoring NCCN, NACB
Parathyroid PTH, calcium Diagnosis, monitoring NCCN, NACB
PTH-related peptide Diagnosis and monitoring NCCN
Hereditary forms HRPT2 Genetic risk assessment NACB
for parathyroid
carcinoma or primary
hyperparathyroidism
MEN1 Genetic risk assessment AACE, NACB, NCCN
for MEN1
RET Genetic risk assessment AACE, NACB, NCCN
for MEN2

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NCCN = National Comprehensive Cancer Network, AACE = American Association of Clinical Endocrinologists, NACB = National Academy
of Clinical Biochemistry

Lab Tests
Indications for Laboratory Testing
Tests generally appear in the order most useful for common clinical situations. For test-specific information, refer to the
test number in the ARUP Laboratory Test Directory on the ARUP Web site at www.aruplab.com.

Gastrointestinal
Test Name and Number Comments
Alpha Fetoprotein, Serum HCC tumor marker
(Tumor Marker) 0080428
Method:
Electrochemiluminescent
Immunoassay
PIK3CA Mutation HCC and colorectal tumor marker
Detection 2004510
Method:
Polymerase Chain
Reaction/Pyrosequencing
Alpha Fetoprotein, Total Risk assessment for development of HCC in patients with chronic liver diseases
and L3 Percent Effective
Immediately 0081208
Method: Liquid-Phase
Binding Immunoassay
Alpha-1-Fetoprotein (AFP) Gastrointestinal tumor marker
by Immunohistochemistry
2003436
Method:
Immunohistochemistry
Des-gamma-carboxy Tumor marker for HCC monitoring, prognosis and early detection in high-risk
Prothrombin 0081312 patients
Method: Liquid-Phase
Binding Immunoassay
Cancer Antigen-GI (CA Pancreatic cancer tumor marker
19-9), Body Fluid 0020746
Method:
Electrochemiluminescent
Immunoassay
Cancer Antigen-GI (CA Tumor marker for pancreatic ductal adenocarcinoma
19-9) 0080461
Method:
Electrochemiluminescent
Immunoassay
Pancreatobiliary FISH Pancreatic cancer tumor marker
2002461
Method:
Fluorescence in situ
Hybridization/Automated

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Image Analysis or Manual


Screening
Carcinoembryonic Antigen Colorectal cancer tumor marker
0080080
Method:
Eletrochemiluminescent
Immunoassay
Gastrointestinal Stromal Determine presence of KIT and PDGFRA mutations
Tumor Mutation 2002674
Method: Polymerase
Chain Reaction/High
Resolution Melt Analysis
BRAF V600E Mutation Lynch syndrome tumor marker
with Reflex to MLH1
Promoter Methylation,
Paraffin 0051750
Method:
Polymerase Chain
Reaction/Fluorescence
Resonance Energy
Transfer Analysis
BRAF V600E Mutation Lynch syndrome tumor marker
Detection by PCR Predict response to EGFR-directed therapy
2002498
Method:
Polymerase Chain
Reaction/Fluorescence
Monitoring
Mismatch Repair by IHC Colorectal cancer and Lynch syndrome tumor marker
0049302
Method:
Immunohistochemistry
HNPCC/Lynch Syndrome, Lynch syndrome tumor marker
Microsatellite Instability by
PCR 0051740
Method: Polymerase
Chain Reaction/Fragment
Analysis
HNPCC/Lynch Syndrome Germline test for Lynch syndrome
Deletion/ For PMS2 testing, suspected deletions or duplication in exons 12-15 require
Duplication 2001728 sequencing to exclude pseudogene copy number variants
Method: Polymerase
Chain Reaction/Multiplex
Ligation-dependent Probe
Amplification
KRAS Mutation Detection Use for therapy with EGFR inhibitors
0040248 Assay detects mutations in codons 12, 13, and 61
Method:
Polymerase Chain
Reaction/Pyrosequencing

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KRAS Mutation Detection Use for therapy with EGFR inhibitors


with Reflex to BRAF Assay detects mutations in codons 12, 13, and 61
Codon 600 Mutation
Detection 2001932 Detects mutations in codons 12, 13, and 61; if KRAS is not detected, BRAF codon
Method: Polymerase 600 Mutation Detection will be performed
Chain Reaction/
Pyrosequencing/
Fluorescence Resonance
Energy Transfer
NRAS Mutation Detection Use in metastatic tumors to predict response to EGFR-directed therapy
by Pyrosequencing
2003123
Method:
Polymerase Chain
Reaction/Pyrosequencing
Carcinoembryonic Gastrointestinal tumor marker
Antigen, Monoclonal
(CEA M) by
Immunohistochemistry
2003824
Method:
Immunohistochemistry
Carcinoembryonic Gastrointestinal tumor marker
Antigen, Polyclonal
(CEA P) by
Immunohistochemistry
2003827
Method:
Immunohistochemistry
E-Cadherin by Gastrointestinal tumor marker
Immunohistochemistry
2003869
Method:
Immunohistochemistry
CD117 (c-Kit) by Gastrointestinal tumor marker
Immunohistochemistry
2003806
Method:
Immunohistochemistry
Cytokeratin 7 (CK 7) by Gastrointestinal tumor marker
Immunohistochemistry
2003854
Method:
Immunohistochemistry
Helicobacter pylori by Risk marker for gastrointestinal cancer
Immunohistochemistry
2003941
Method:
Immunohistochemistry
Human Chorionic Gastrointestinal and pancreatic tumor marker
Gonadotropin (Beta-hCG)

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by Immunohistochemistry
2003920
Method:
Immunohistochemistry
Villin by Gastrointestinal tumor marker
Immunohistochemistry
2004178
Method:
Immunohistochemistry
CDX2 by Gastrointestinal tumor marker
Immunohistochemistry
2003821
Method:
Immunohistochemistry
Muc-1 by Gastrointestinal tumor marker
Immunohistochemistry
2004002
Method:
Immunohistochemistry
Muc-2 by Gastrointestinal tumor marker
Immunohistochemistry
2004005
Method:
Immunohistochemistry
Muc-4 by Gastrointestinal tumor marker
Immunohistochemistry
2004008
Method:
Immunohistochemistry
Muc 5AC by Gastrointestinal tumor marker
Immunohistochemistry
2003999
Method:
Immunohistochemistry
Breast Carcinoma b72.3 Gastrointestinal tumor marker
by Immunohistochemistry
2003445
Method:
Immunohistochemistry
Gastrin by Gastrointestinal tumor marker
Immunohistochemistry
2003896
Method:
Immunohistochemistry
p27 (Kip1) by Gastrointestinal tumor marker
Immunohistochemistry
2004070
Method:
Immunohistochemistry

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Cytokeratin 20 (CK 20) Gastrointestinal tumor marker


by Immunohistochemistry
2003848
Method:
Immunohistochemistry

Neuroendocrine
Test Name and Number Comments
Chromogranin A 0080469 Neuroendocrine cancer tumor marker
Method: Enzyme
Immunoassay
Chromogranin A by Neuroendocrine tumor marker
Immunohistochemistry
2003830
Method:
Immunohistochemistry
Pan Cytokeratin Neuroendocrine tumor marker
(AE1,3) by
Immunohistochemistry
2003433
Method:
Immunohistochemistry
Adrenocorticotropic Neuroendocrine tumor marker
Hormone (ACTH) by
Immunohistochemistry
2003427
Method:
Immunohistochemistry
Calcitonin by Neuroendocrine tumor marker
Immunohistochemistry
2003481
Method:
Immunohistochemistry
Growth Hormone by Neuroendocrine tumor marker
Immunohistochemistry
2003929
Method:
Immunohistochemistry
Insulin by Neuroendocrine tumor marker
Immunohistochemistry
2003972
Method:
Immunohistochemistry
Ki-67 Tissue Assay, Neuroendocrine tumor marker
Paraffin 0049270
Method:
Immunohistochemistry

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Gastrin by Neuroendocrine tumor marker


Immunohistochemistry
2003896
Method:
Immunohistochemistry
Glucagon by Neuroendocrine tumor marker
Immunohistochemistry
2003902
Method:
Immunohistochemistry
Parathyroid Neuroendocrine tumor marker
Hormone (PTH) by
Immunohistochemistry
2004118
Method:
Immunohistochemistry
Prolactin by Neuroendocrine tumor marker
Immunohistochemistry
2004109
Method:
Immunohistochemistry
Somatostatin by Neuroendocrine tumor marker
Immunohistochemistry
2004133
Method:
Immunohistochemistry
Synaptophysin by Neuroendocrine tumor marker
Immunohistochemistry
2004139
Method:
Immunohistochemistry
Thyroglobulin by Neuroendocrine tumor marker
Immunohistochemistry
2004145
Method:
Immunohistochemistry
Thyroid Transcription Neuroendocrine tumor marker
Factor (TTF-1) by
Immunohistochemistry
2004166
Method:
Immunohistochemistry
Protein Gene Carcinoid tumor marker
Product (PGP) 9.5 by
Immunohistochemistry
2004091
Method:
Immunohistochemistry

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CDX2 by Pancreatic neuroendocrine tumor marker


Immunohistochemistry
2003821
Method:
Immunohistochemistry
Cytokeratin 8,18 Carcinoid tumor marker
Low Molecular
Weight (CAM 5.2) by
Immunohistochemistry
2003493
Method:
Immunohistochemistry
Neuron Specific Enolase, Neuroendocrine tumor marker
Polyclonal (NSE P) by
Immunohistochemistry
2004052
Method:
Immunohistochemistry
5-Hydroxyindoleacetic Carcinoid tumor marker
Acid (HIAA), Urine
0080420
Method: High
Performance Liquid
Chromatography
Serotonin, Neuroendocrine cancer tumor marker
Serum 0080397
Method: High
Performance Liquid
Chromatography
Serotonin, Whole Neuroendocrine cancer tumor marker
Blood 0080395
Method: High
Performance Liquid
Chromatography
Gastrin 0070075 Neuroendocrine cancer tumor marker
Method:
Chemiluminescent
Immunoassay
Glucagon 0099165 Neuroendocrine cancer tumor marker
Method:
Radioimmunoassay
Catecholamines Neuroblastoma tumor marker
Fractionated by
LC-MS/MS, Urine Free
0080407
Method: Tandem Mass
Spectrometry
Proinsulin 0070112 Neuroendocrine cancer tumor marker
Method: Two-Site Enzyme
Immunoassay

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Homovanillic Acid (HVA), Neuroblastoma tumor marker


Urine 0080422
Method: High
Performance Liquid
Chromatography
Vanillylmandelic Acid Neuroblastoma tumor marker
(VMA) & Homovanillic
Acid (HVA), Urine
0080470
Method: High
Performance Liquid
Chromatography
Metanephrines, Plasma Preferred marker for the diagnosis of pheochromocytoma
(Free) 0050184
Method: High
Performance Liquid
Chromatography
Metanephrines, Urine Pheochromocytoma tumor marker
0080436
Method: Gas
Chromatography/Mass
Spectrometry
Proinsulin/Insulin Ratio Neuroendocrine cancer tumor marker
0070256
Method: Refer to
individual components
Vasoactive Intestinal Neuroendocrine cancer tumor marker
Peptide 0099435
Method:
Radioimmunoassay
Pancreatic Polypeptide Neuroendocrine cancer tumor marker
0099436
Method:
Radioimmunoassay
Muc-1 by Neuroendocrine tumor marker
Immunohistochemistry
2004002
Method:
Immunohistochemistry
Muc-2 by Neuroendocrine tumor marker
Immunohistochemistry
2004005
Method:
Immunohistochemistry
Muc-4 by Neuroendocrine tumor marker
Immunohistochemistry
2004008
Method:
Immunohistochemistry

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Muc 5AC by Neuroendocrine tumor marker


Immunohistochemistry
2003999
Method:
Immunohistochemistry

Lung
Test Name and Number Comments
Neuron Specific Enolase SCLC tumor marker
0098198
Method: Enzyme-Linked
Immunosorbent Assay
Chromogranin A 0080469 SCLC tumor marker
Method: Enzyme
Immunoassay
Cytokeratin 19 Fragment SCLC tumor marker
(CYFRA 21-1), Serum
0081344
Method: Enzyme-Linked
Immunosorbent Assay
Soluble Mesothelin Mesothelioma marker
Related Peptides
®
(MESOMARK ) 0081284
Method: Enzyme-Linked
Immunosorbent Assay
CDX2 by Lung tumor marker
Immunohistochemistry
2003821
Method:
Immunohistochemistry
Cytokeratin 19 (CK 19) Lung tumor marker
by Immunohistochemistry
2003845
Method:
Immunohistochemistry
Carcinoembryonic Lung tumor marker
Antigen, Monoclonal
(CEA M) by
Immunohistochemistry
2003824
Method:
Immunohistochemistry
Carcinoembryonic Lung tumor marker
Antigen, Polyclonal
(CEA P) by
Immunohistochemistry
2003827
Method:
Immunohistochemistry

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Cytokeratin 5,6 (CK 5,6) Lung tumor marker


by Immunohistochemistry
2003851
Method:
Immunohistochemistry
Chromogranin A by Lung tumor marker
Immunohistochemistry
2003830
Method:
Immunohistochemistry
Cytokeratin 7 (CK 7) by Lung tumor marker
Immunohistochemistry
2003854
Method:
Immunohistochemistry
Cytokeratin 20 (CK 20) Lung tumor marker
by Immunohistochemistry
2003848
Method:
Immunohistochemistry
Wilms Tumor (WT-1), Lung tumor marker
N-terminus by
Immunohistochemistry
2004184
Method:
Immunohistochemistry
Neuron Specific Enolase, Lung tumor marker
Polyclonal (NSE P) by
Immunohistochemistry
2004052
Method:
Immunohistochemistry
Neurofilament by Lung tumor marker
Immunohistochemistry
2004049
Method:
Immunohistochemistry
Calretinin by Lung tumor marker
Immunohistochemistry
2003490
Method:
Immunohistochemistry
Breast Carcinoma b72.3 Lung tumor marker
by Immunohistochemistry
2003445
Method:
Immunohistochemistry
p27 (Kip1) by Lung tumor marker
Immunohistochemistry
2004070

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Method:
Immunohistochemistry
Thyroid Transcription Lung tumor marker
Factor (TTF-1) by
Immunohistochemistry
2004166
Method:
Immunohistochemistry
Human Chorionic Lung tumor marker
Gonadotropin (Beta-hCG)
by Immunohistochemistry
2003920
Method:
Immunohistochemistry

Female Gynecologic/Genitourinary
Test Name and Number Comments
ERBB2 (HER-2/neu) Breast cancer tumor marker (test is graded 0-3 in a semi-quantitative manner)
(4B5) Tissue Assay,
Paraffin 2002218
Method:
Immunohistochemistry
ERBB2 (HER-2/neu) Breast cancer tumor marker (test is graded 0-3 in a semi-quantitative manner)
(4B5) with Reflex to
ERBB2 (HER-2/neu)
Gene Amplification by
FISH if 2+ 2002217
Method:
Immunohistochemistry

HER-2/neu (PATHWAY )
® Breast cancer tumor marker (test is graded 0-3 in a semi-quantitative manner)
(4B5) with Reflex to FISH
if 2+ or 3+ 2002216
Method:
Immunohistochemistry
ERBB2 (HercepTest®) Breast cancer tumor marker (test is graded 0-3 in a semi-quantitative manner)
Tissue Assay, Paraffin
0049174
Method:
Immunohistochemistry
ERRB2 (HER-2/neu) Breast cancer tumor marker
Gene Amplification by
FISH 0049218
Method: Fluorescence in
situ Hybridization
ERBB2 (HER-2/neu) Breast cancer tumor marker
Gene Amplification by
CISH 2002443
Method: Chromogenic in
situ Hybridization

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HER-2 Gene Amplification Breast cancer tumor marker


by Monoplex PCR,
Paraffin 0049390
Method: Monoplex
Polymerase Chain
Reaction
Estrogen/Progesterone Breast cancer tumor marker
Receptor Assay, Paraffin
0049210
Method:
Immunohistochemistry
Carcinoembryonic Breast cancer tumor marker
Antigen, Monoclonal
(CEA M) by
Immunohistochemistry
2003824
Method:
Immunohistochemistry
Carcinoembryonic Breast cancer tumor marker
Antigen, Polyclonal
(CEA P) by
Immunohistochemistry
2003827
Method:
Immunohistochemistry
Placental Alkaline Breast cancer tumor marker
Phosphatase (PLAP) by
Immunohistochemistry
2004097
Method:
Immunohistochemistry
Human Chorionic Breast cancer tumor marker
Gonadotropin (Beta-hCG)
by Immunohistochemistry
2003920
Method:
Immunohistochemistry
CD30 (Ki-1) by Breast cancer tumor marker
Immunohistochemistry
2003547
Method:
Immunohistochemistry
Breast 2 (GCDFP-15) by Breast cancer tumor marker
Immunohistochemistry
2003472
Method:
Immunohistochemistry
Cancer Antigen 125 by Breast cancer tumor marker
Immunohistochemistry
2003478

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Method:
Immunohistochemistry
Cytokeratin 20 (CK 20) Breast cancer tumor marker
by Immunohistochemistry
2003848
Method:
Immunohistochemistry
PIK3CA Mutation Breast cancer tumor marker
Detection 2004510
Method:
Polymerase Chain
Reaction/Pyrosequencing
Alpha-1-Fetoprotein (AFP) Germ cell tumor marker
by Immunohistochemistry
2003436
Method:
Immunohistochemistry
Breast Carcinoma b72.3 Breast cancer tumor marker
by Immunohistochemistry
2003445
Method:
Immunohistochemistry
Myeloperoxidase (MPO) Breast cancer tumor marker
by Immunohistochemistry
2004014
Method:
Immunohistochemistry
Cancer Antigen-Breast Breast cancer tumor marker
(CA 15-3) 0080464
Method:
Electrochemiluminescent
Immunoassay
Cancer Antigen 27.29 Breast cancer tumor marker
0080392
Method:
Chemiluminescent
Immunoassay
Carcinoembryonic Antigen Breast cancer tumor marker
0080080
Method:
Electrochemiluminescent
Immunoassay
Ki-67 Tissue Assay, Breast cancer tumor marker
Paraffin 0049270
Method:
Immunohistochemistry
HER-2/neu Quantitative Breast cancer tumor marker
by ELISA 2004672
Method: Enzyme-Linked
Immunosorbent Assay

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PAM50 Breast Cancer Breast cancer tumor marker


Intrinsic Classifier
2004700
Method: Reverse
Transcription/Quantitative
Polymerase Chain
Reaction
p53 Tissue Assay, Paraffin Breast and bladder cancer tumor marker
0049250
Method:
Immunohistochemistry

Cytology, ThinPrep Pap


® Cytologic screening for cervical cancer and its usual precursor lesions
with Reflex to Human
Papillomavirus (HPV)
DNA Probe, High Risk
8100212
®
Method: ThinPrep
2000 System/Routine
Cytopathologic
Evaluation/Nucleic Acid
Probe
Squamous Cell Cervical cancer tumor marker
Carcinoma Antigen,
Serum 0081054
Method: Enzyme-Linked
Immunosorbent Assay
Human Papillomavirus Cervical cancer tumor marker
(HPV) DNA Probe, High
Risk, Cervical Brush
(Digene) 0065999
Method: Nucleic Acid
Probe
Human Papillomavirus Cervical cancer tumor marker
(HPV) DNA Probe,
®
High Risk SurePath
(AutoCyte) 0060744
Method: Nucleic Acid
Probe
Human Papillomavirus Cervical cancer tumor marker
(HPV) DNA Probe, High
®
Risk (ThinPrep ) 0060750
Method: Nucleic Acid
Probe
Human Papillomavirus Cervical cancer tumor marker
(HPV) High Risk in situ
Hybridization, Paraffin
2002899
Method: In situ
Hybridization

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Cancer Antigen 125 Ovarian cancer tumor marker


0080462
Method:
Electrochemiluminescent
Immunoassay
Human Epididymis Protein Ovarian cancer tumor marker
4 (HE4) 2003020
Method: Enzyme
Immunoassay
Beta-hCG, Quantitative Tumor marker for gestational trophoblastic disease and ovarian cancer
(Tumor Marker) 0070029
Method:
Chemiluminescent
Immunoassay
Bladder Tumor Associated Urine-based bladder cancer tumor marker
Antigen 8100500
Method: Qualitative
Immunoassay

UroVysion FISH Urine-based bladder cancer molecular genetic test
8100600
Method:
Fluorescence in situ
Hybridization/Automated
Image Analysis or Manual
Screening
CDX2 by Tumor marker for breast, ovarian, and uterine cancers
Immunohistochemistry
2003821
Method:
Immunohistochemistry
Placental Alkaline Germ cell (ovarian) tumor marker
Phosphatase (PLAP) by
Immunohistochemistry
2004097
Method:
Immunohistochemistry
p16 by Bladder cancer tumor marker
Immunohistochemistry
2004064
Method:
Immunohistochemistry
p21, WAF, CIP1 by Bladder cancer tumor marker
Immunohistochemistry
2004067
Method:
Immunohistochemistry
p27 by Bladder cancer tumor marker
Immunohistochemistry
2004070

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Method:
Immunohistochemistry
CD8 by Bladder cancer tumor marker
Immunohistochemistry
2003520
Method:
Immunohistochemistry

Male Genitourinary
Test Name and Number Comments
Prostate Specific Antigen, Prostate cancer tumor marker
Ultrasensitive 0098581
Method:
Electrochemiluminescent
Immunoassay
Prostate Specific Antigen, Prostate cancer tumor marker
Total with Reflex to Free
PSA
(Includes Free
Percentage) 0080264
Method:
Electrochemiluminescent
Immunoassay
PIK3CA Mutation Prostate cancer tumor marker
Detection 2004510
Method:
Polymerase Chain
Reaction/Pyrosequencing
Prostate Specific Antigen, Marker for recurrence after radical prostatectomy
0070121
Method:
Electrochemiluminescent
Immunoassay
PCA3 - Prostate Cancer Prostate cancer tumor marker; use if PSA is >10 ng/mL and biopsy negative
Biomarker 2001999
Method:
Transcription-mediated
Amplification/
Hybridization Protection
Assay
Bladder Tumor Associated Urine-based bladder cancer tumor marker
Antigen 8100500
Method: Qualitative
Immunoassay
®
NMP22 0080281 Male bladder cancer tumor marker
Method: Enzyme
Immunoassay

UroVysion

FISH Urine-based bladder cancer tumor marker
8100600

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Method:
Fluorescence in situ
Hybridization/Automated
Image Analysis
or Manual Screening
Beta-hCG, Quantitative Testicular cancer (germ cell) tumor marker
(Tumor Marker) 0070029
Method:
Chemiluminescent
Immunoassay
Alpha Fetoprotein, Serum Testicular cancer (germ cell) tumor marker
(Tumor Marker) 0080428
Method:
Electrochemiluminescent
Immunoassay
Ki-67 Tissue Assay, Bladder cancer tumor marker
Paraffin (Mib-1) 0049270
Method:
Immunohistochemistry
p53 Tissue Assay, Paraffin Bladder cancer tumor marker
0049250
Method:
Immunohistochemistry
Placental Alkaline Testicular cancer (germ cell) tumor marker
Phosphatase (PLAP) by
Immunohistochemistry
2004097
Method:
Immunohistochemistry
Human Chorionic Testicular cancer (germ cell) tumor marker
Gonadotropin (Beta-hCG)
by Immunohistochemistry
2003920
Method:
Immunohistochemistry
p16 by Bladder cancer tumor marker
Immunohistochemistry
2004064
Method:
Immunohistochemistry
p21, WAF, CIP1 by Bladder cancer tumor marker
Immunohistochemistry
2004067
Method:
Immunohistochemistry
p27 by Bladder cancer tumor marker
Immunohistochemistry
2004070
Method:
Immunohistochemistry

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CD8 by Bladder cancer tumor marker


Immunohistochemistry
2003520
Method:
Immunohistochemistry
Cytokeratin 20 (CK 20) Bladder cancer tumor marker
by Immunohistochemistry
2003848
Method:
Immunohistochemistry
Prostate Specific Antigen Prostate cancer marker
by Immunohistochemistry
2004112
Method:
Immunohistochemistry

Brain
Test Name and Number Comments
1p/19q Deletion by FISH Oligodendroglioma marker
0049360
Method: Fluorescence in
situ Hybridization
Neurofilament by Brain tumor marker
Immunohistochemistry
2004049
Method:
Immunohistochemistry
PIK3CA Mutation Brain tumor marker
Detection 2004510
Method:
Polymerase Chain
Reaction/Pyrosequencing
CD68, KP1 by Glioma tumor marker
Immunohistochemistry
2003598
Method:
Immunohistochemistry

Soft Tissue/Sarcomas
Test Name and Number Comments
EWSR1 (22q12) Gene Ewing sarcoma tumor marker
Rearrangement by FISH
0049335
Method: Fluorescence in
situ Hybridization
SYT-SSX t(X;18) Sarcomas tumor marker
Translocations by
RT-PCR 0040114

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Method: Reverse
Transcription
Polymerase Chain
Reaction/Fluorescence
Monitoring
SS18 (SYT) (18q11) Gene Sarcomas tumor marker
Rearrangement by FISH
0049380
Method: Fluorescence in
situ Hybridization
Kaposi Sarcomas tumor marker
Sarcoma-Associated
Herpesvirus/Human
Herpesvirus 8 0055629
Method:
Polymerase Chain
Reaction/Fluorescence
Monitoring
Herpes Virus 8 by Kaposi sarcoma tumor marker
Immunohistochemistry
2003932
Method:
Immunohistochemistry
Wilms Tumor (WT-1), Sarcomas tumor marker
N-terminus by
Immunohistochemistry
2004184
Method:
Immunohistochemistry
Myogenin (Myf4) by Rhabdomyosarcoma tumor marker
Immunohistochemistry
2004017
Method:
Immunohistochemistry
Myoglobin by Rhabdomyosarcoma tumor marker
Immunohistochemistry
2004031
Method:
Immunohistochemistry
Myosin by Rhabdomyosarcoma tumor marker
Immunohistochemistry
2004034
Method:
Immunohistochemistry
PAX-FKHR Translocation Rhabdomyosarcoma tumor marker
by RT-PCR 0040113
Method: Reverse
Transcription
Polymerase Chain
Reaction/Fluorescence
Monitoring

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MDM2 Gene Amplification Sarcomas tumor marker


by FISH 2003016
Method: Fluorescence in
situ Hybridization

Lymphoma
Test Name and Number Comments
IGH-BCL2 (BCL-2/JH) Non-Hodgkin lymphoma (NHL) tumor marker
Translocation, t(14;18) by
PCR, Fluid 0055616
Method: Polymerase
Chain Reaction
IGH-CCND1 (BCL-1/JH) NHL tumor marker
Translocation, t(11;14) by
PCR, Fluid 0055557
Method: Polymerase
Chain Reaction
Chromosome FISH, Monitor disease and identify specific abnormalities suspected clinically
Interphase 2002298 Specific FISH probes must be requested – ARUP Oncology FISH Probes menu
Method: Fluorescence in
situ Hybridization
BIRC2-MALT1 Tumor marker for leukemia lymphoma phenotyping and mucosa-associated
(AP12-MALT1) lymphoid tissue lymphoma (MALT)
Translocation, t(11;18) by
RT-PDR 0055691
Method: Reverse
Transcription Polymerase
Chain Reaction
IGH-CCND1 Fusion, Lymphoma classification/identification tumor marker
t(11;14) by FISH 0049381
Method: Fluorescence in
situ Hybridization
MYC (8q;24) Gene Burkitt lymphoma tumor marker
Rearrangement by FISH
2002345
Method: Fluorescence in
situ Hybridization
CD117 (c-Kit) by Lymphoma tumor marker
Immunohistochemistry
2003806
Method:
Immunohistochemistry
Octamer Transcription Lymphoma tumor marker
Factor-2 (Oct-2) by
Immunohistochemistry
2004061
Method:
Immunohistochemistry

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CD14 by Lymphoma tumor marker


Immunohistochemistry
2003526
Method:
Immunohistochemistry
CD15, Leu M1 by Lymphoma tumor marker
Immunohistochemistry
2003529
Method:
Immunohistochemistry
CD20, L26 by Lymphoma tumor marker
Immunohistochemistry
2003532
Method:
Immunohistochemistry
CD45 by Marker for diffuse large B-cell lymphoma
Immunohistochemistry
2003574
Method:
Immunohistochemistry
CD56 (NCAM) by Lymphoma tumor marker
Immunohistochemistry
2003589
Method:
Immunohistochemistry
CD57 by Lymphoma tumor marker
Immunohistochemistry
2003592
Method:
Immunohistochemistry
Pax-5 by Lymphoma tumor marker
Immunohistochemistry
2004082
Method:
Immunohistochemistry
BCL-6 by Lymphoma tumor marker
Immunohistochemistry
2003457
Method:
Immunohistochemistry
Anaplastic Lymphoma Lymphoma tumor marker
Kinase 1 (ALK-1) by
Immunohistochemistry
2003439
Method:
Immunohistochemistry
Ki-67 Tissue Assay, Lymphoma tumor marker
Paraffin (Mib-1) 0049270
Method:
Immunohistochemistry

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Cyclin D1, SP4 by Lymphoma tumor marker


Immunohistochemistry
2003842
Method:
Immunohistochemistry
MUM1/IRF4 by Lymphoma tumor marker
Immunohistochemistry
2003975
Method:
Immunohistochemistry
CD23 by Lymphoma tumor marker
Immunohistochemistry
2003541
Method:
Immunohistochemistry
CD10 (CALLA) by Lymphoma tumor marker
Immunohistochemistry
2003523
Method:
Immunohistochemistry
CD8 by Lymphoma tumor marker
Immunohistochemistry
2003520
Method:
Immunohistochemistry
CD5 by Lymphoma tumor marker
Immunohistochemistry
2003514
Method:
Immunohistochemistry
CD7 by Lymphoma tumor marker
Immunohistochemistry
2003517
Method:
Immunohistochemistry
BF-1 by Lymphoma tumor marker
Immunohistochemistry
2003466
Method:
Immunohistochemistry
B Cell Specific Octamer Lymphoma tumor marker
Binding Protein-1 (BOB-1)
by Immunohistochemistry
2003442
Method:
Immunohistochemistry
CD2 by Lymphoma tumor marker
Immunohistochemistry
2003505

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Method:
Immunohistochemistry
CD3 by Lymphoma tumor marker
Immunohistochemistry
2003508
Method:
Immunohistochemistry
CD4 by Lymphoma tumor marker
Immunohistochemistry
2003511
Method:
Immunohistochemistry
CD19 by B-cell lymphoma tumor marker
Immunohistochemistry
2005114
Method:
Immunohistochemistry
CD138 (Syndecan-1) by Lymphoma tumor marker
Immunohistochemistry
2003812
Method:
Immunohistochemistry
T-cell Intracytoplasmic Lymphoma tumor marker
Antigen (TIA-1) by
Immunohistochemistry
2004148
Method:
Immunohistochemistry
Epstein-Barr Virus (EBV) Lymphoma tumor marker
By in situ Hybridization,
Paraffin 2002902
Method: In situ
Hybridization

Leukemia
Test Name and Number Comments
Chromosome FISH, Chronic lymphocytic leukemia (CLL) tumor marker
CLL Panel 2002295
Method: Fluorescence in
situ Hybridization
Chromosome FISH, Monitor disease and identify specific abnormalities suspected clinically
Interphase 2002298 Specific FISH probes must be requested – ARUP Oncology FISH Probes menu
Method: Fluorescence in
situ Hybridization
TCF3-PBX1 (E2A-PBX1) Acute lymphocytic leukemia (ALL) tumor marker
Translocation, t(1;19) by
RT-PCR 0055346
Method: Reverse
Transcription

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Polymer/Polymerase
Chain Reaction
ETV6-RUNX1 AML tumor marker
(TEL-AML1)
Translocation, t(12;21) by
RT-PCR 0056008
Method: Reverse
Transcription Polymerase
Chain Reaction
RUNX1-RUNX1T1 Acute myelogenous leukemia (AML) tumor marker
(AML1-ETO)
Translocation, t(8;21) by
RT-PCR 0050444
Method: Reverse
Transcription Polymerase
Chain Reaction
CBFB-MYH1, inv(16) by AML tumor marker
RT PCR 0092209
Method: Reverse
Transcription Polymerase
Chain Reaction
PML/RARα FISH 2002363 AML tumor marker
Method: Fluorescence in
situ Hybridization
ZAP-70 Analysis by Flow AML tumor marker
Cytometry 0092392
Method: Flow Cytometry
BCR-ABL1 Kinase Tumor marker to monitor drug therapy for CML and ALL
Domain Mutation Analysis Detects >90% of mutations that may lead to imatinib resistance
0040138
Method:
Polymerase Chain
Reaction/Sequencing
BCR-ABL1, Major (p210), Tumor marker for CML and ALL therapy
Quantitative 2005017
Method: Reverse
Transcription/Quantitative
Polymerase Chain
Reaction
BCR-ABL1, Minor (p190), Tumor marker for CML and ALL therapy
Quantitative 2005016
Method: Reverse
Transcription/Quantitative
Polymerase Chain
Reaction
BCR-ABL1, T315I Tumor marker for CML and ALL therapy
Mutation Detection,
Quantitative 2004924
Method: Reverse
Transcription

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Polymerase Chain
Reaction/Pyrosequencing
BCR-ABL1, Major (p210), Tumor marker for CML and ALL therapy
Quantitative 2005010
Method: Reverse
Transcription Polymerase
Chain Reaction
PIK3CA Mutation Leukemia tumor marker
Detection 2004510
Method:
Polymerase Chain
Reaction/Pyrosequencing
CD117 (c-Kit) by Leukemia tumor marker
Immunohistochemistry
2003806
Method:
Immunohistochemistry
CD14 by Leukemia tumor marker
Immunohistochemistry
2003526
Method:
Immunohistochemistry
CD15, Leu M1 by Leukemia tumor marker
Immunohistochemistry
2003529
Method:
Immunohistochemistry
CD19 by B-cell leukemia tumor marker
Immunohistochemistry
2005114
Method:
Immunohistochemistry
CD20, L26 by Leukemia tumor marker
Immunohistochemistry
2003532
Method:
Immunohistochemistry
CD33 by AML tumor marker
Immunohistochemistry
2003553
Method:
Immunohistochemistry
CD56 (NCAM) by Leukemia tumor marker
Immunohistochemistry
2003589
Method:
Immunohistochemistry
Wilms Tumor (WT-1), Leukemia tumor marker
N-terminus by

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Immunohistochemistry
2004184
Method:
Immunohistochemistry
Pax-5 by Leukemia tumor marker
Immunohistochemistry
2004082
Method:
Immunohistochemistry
CD10 (CALLA) by Leukemia tumor marker
Immunohistochemistry
2003523
Method:
Immunohistochemistry
Cyclin D1, SP4 by Leukemia tumor marker
Immunohistochemistry
2003842
Method:
Immunohistochemistry
CD23 by Leukemia tumor marker
Immunohistochemistry
2003541
Method:
Immunohistochemistry
CD2 by Leukemia tumor marker
Immunohistochemistry
2003505
Method:
Immunohistochemistry
CD3 by Leukemia tumor marker
Immunohistochemistry
2003508
Method:
Immunohistochemistry
CD5 by Leukemia tumor marker
Immunohistochemistry
2003514
Method:
Immunohistochemistry
CD57 by Leukemia tumor marker
Immunohistochemistry
2003592
Method:
Immunohistochemistry
BCL-6 by Leukemia tumor marker
Immunohistochemistry
2003457
Method:
Immunohistochemistry

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CD79A by Leukemia tumor marker


Immunohistochemistry
2003800
Method:
Immunohistochemistry
TdT by Leukemia tumor marker
Immunohistochemistry
2004142
Method:
Immunohistochemistry
Epstein-Barr Virus (EBV) Leukemia tumor marker
By in situ Hybridization,
Paraffin 2002902
Method: In situ
Hybridization

Myeloproliferative Neoplasms
Test Name and Number Comments
JAK2 Gene, V617F Myeloproliferative neoplasms (MPN) tumor marker
Mutation, Quantitation
0040168
Method: Polymerase
Chain Reaction
JAK2 Gene, V617F MPN tumor marker
Mutation, Qualitative
0051245
Method: Polymerase
Chain Reaction
JAK2 Exon 12 Mutation MPN tumor marker
Analysis by PCR 2002357
Method: Polymerase
Chain Reaction

Childhood Tumors
Test Name and Number Comments
Neuron Specific Enolase 0098198 Marker for germ cell tumors
Method: Enzyme-Linked Immunosorbent Assay
MYCN (N-MYC) Gene Amplification by FISH 0049235 Neuroblastoma (childhood tumors) tumor marker
Method: Fluorescence in situ Hybridization
Homovanillic Acid (HVA), Urine 0080422 Neuroblastoma (childhood tumors) tumor marker
Method: High Performance Liquid Chromatography
Vanillylmandelic Acid (VMA) & Homovanillic Acid Neuroblastoma (childhood tumors) tumor marker
(HVA), Urine 0080470
Method: High Performance Liquid Chromatography
Catecholamines Fractionated by LC-MS/MS, Urine Neuroblastoma (childhood tumors) tumor marker
Free 0080407
Method: Tandem Mass Spectometry

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MLL-AFF1 (MLL-AF4) Translocation, t(4;11) by Infant leukemia tumor marker


RT-PCR 0050446
Method: Reverse Transcription Polymerase Chain
Reaction
Chromosome FISH, Interphase 2002298 Monitor disease and identify specific abnormalities
Method: Fluorescence in situ Hybridization suspected clinically
Specific FISH probes must be requested – ARUP
Oncology FISH Probes menu
LSI MYC t(8q;24) by FISH 2002345 Burkitt lymphoma tumor marker
Method: Fluorescence in situ Hybridization

Skin
Test Name and Number Comments
S-100B Protein, Serum 2001766 Monitor treatment and determine prognosis in patients
Method: Enzyme-Linked Immunosorbent Assay with melanoma
NRAS Mutation Detection by Use in metastatic tumors to predict response to
Pyrosequencing 2003123 EGFR-directed therapy
Method: Polymerase Chain Reaction/Pyrosequencing
BRAF V600E Mutation Detection by PCR 2002498 Predict response to EGFR-directed therapy
Method: Polymerase Chain Reaction/Fluorescence
Monitoring
KIT Mutations, Melanoma 2002695 Predict response to EGFR-directed therapy
Method: Polymerase Chain Reaction/High Resolution
Melt Analysis
CD117 (c-Kit) by Immunohistochemistry 2003806 Melanoma tumor marker
Method: Immunohistochemistry
CD56 (NCAM) by Immunohistochemistry 2003589 Melanoma tumor marker
Method: Immunohistochemistry
Melan A by Immunohistochemistry 2003996 Melanoma tumor marker
Method: Immunohistochemistry
S-100 Protein by Immunohistochemistry 2004127 Melanoma tumor marker
Method: Immunohistochemistry
Melanoma Antibody, HMB45 by Melanoma tumor marker
Immunohistochemistry 2003935
Method: Immunohistochemistry
Human Chorionic Gonadotropin (Beta-hCG) by Melanoma tumor marker
Immunohistochemistry 2003920
Method: Immunohistochemistry

Head & Neck


Test Name and Number Comments
Squamous Cell Tumor marker for NSCLC, head and neck cancer - squamous cell carcinoma
Carcinoma Antigen, (SCC)
Serum 0081054
Method: Enzyme-Linked
Immunosorbent Assay

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Cytokeratin 19 Fragment Squamous cell cancer tumor marker


(CYFRA 21-1), Serum
0081344
Method: Enzyme-Linked
Immunosorbent Assay
Human Papillomavirus Head and neck cancer marker
(HPV) High Risk in situ
Hybridization, Paraffin
2002899
Method: In situ
Hybridization
Epstein-Barr Virus (EBV) Head and neck cancer marker
by in situ Hybridization,
Paraffin 2002902
Method: In situ
Hybridization
Cytokeratin 19 (CK 19) Head and neck cancer marker
by Immunohistochemistry
2003845
Method:
Immunohistochemistry
CD68, KP1 by Head and neck cancer marker
Immunohistochemistry
2003598
Method:
Immunohistochemistry

Thyroid/Parathyroid
Test Name and Number Comments
Thyroglobulin, Serum or Thyroid cancer tumor marker
Plasma 0070421
Method:
Chemiluminescent
Immunoassay
Thyroglobulin Antibody Thyroid tumor marker
0050105
Method:
Chemiluminescent
Immunoassay
BRAF V600E Mutation Thyroid cancer tumor marker
Detection by PCR
2002498
Method:
Polymerase Chain
Reaction/Fluorescence
Monitoring
Thyroglobulin, Fine Thyroid tumor marker
Needle Aspiration (FNA)
0020753

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The Physician's Guide to Laboratory Test Selection and Interpretation

Method:
Chemiluminescent
Immunoassay
Parathyroid Hormone, Parathyroid cancer tumor marker
Intact with Calcium
0070172
Method:
Electrochemiluminescent
Immunoassay
Multiple Endocrine Hereditary thyroid cancer genetic marker
Neoplasia Type 2 (MEN2),
RET Gene Mutations by
Sequencing 0051390
Method:
Polymerase Chain
Reaction/Sequencing
Multiple Endocrine Hereditary thyroid cancer genetic marker
Neoplasia Type 2B (RET)
2 Mutations 0051492
Method:
Polymerase Chain
Reaction/Fluorescence
Monitoring
CDX2 by Thyroid/parathyroid tumor marker
Immunohistochemistry
2003821
Method:
Immunohistochemistry
Parathyroid Parathyroid tumor marker
Hormone (PTH) by
Immunohistochemistry
2004118
Method:
Immunohistochemistry
Muc-1 by Thyroid tumor marker
Immunohistochemistry
2004002
Method:
Immunohistochemistry
Muc-2 by Thyroid tumor marker
Immunohistochemistry
2004005
Method:
Immunohistochemistry
Muc-4 by Thyroid tumor marker
Immunohistochemistry
2004008
Method:
Immunohistochemistry

ARUP LABORATORIES | 500 Chipeta Way | Salt Lake City, Utah 84108-1221 | (800) 522-2787 | www.arupconsult.com | www.aruplab.com
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The Physician's Guide to Laboratory Test Selection and Interpretation

Thyroglobulin by Thyroid tumor marker


Immunohistochemistry
2004145
Method:
Immunohistochemistry
Thyroid Transcription Thyroid tumor marker
Factor (TTF-1) by
Immunohistochemistry
2004166
Method:
Immunohistochemistry
p27 (Kip1) by Thyroid tumor marker
Immunohistochemistry
2004070
Method:
Immunohistochemistry
Calcitonin by Parathyroid tumor marker
Immunohistochemistry
2003481
Method:
Immunohistochemistry

Guidelines

National Academy of Clinical Biochemistry. [Accessed: 27 Apr 2009]

NCCN Clinical Practice Guidelines. National Comprehensive Cancer Network. Fort Washington: Pennsylvania
[Accessed: 3 Feb 2011]

General References
Bakhshi S, Radhakrishnan V. Prognostic markers in osteosarcoma.Expert Rev Anticancer Ther. 2010; 10 (2) :271-287.
Duffy MJ, Sturgeon C, Lamerz R, Haglund C, Holubec VL, Klapdor R, Nicolini A, Topolcan O, Heinemann V. Tumor
markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report.Ann Oncol. 2010; 21 (3)
:441-447.
McGuire BB, Fitzpatrick JM. Biomarkers in renal cell carcinoma.Curr Opin Urol. 2009; 19 (5) :441-446.
Mowatt G, Zhu S, Kilonzo M, Boachie C, Fraser C, Griffiths TR, N'Dow J, Nabi G, Cook J, Vale L. Systematic review of
the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt,
NMP22) and cytology for the detection and follow-up of bladder cancer.Health Technol Assess. 2010; 14 (4) :1-iv.
Na YJ, Farley J, Zeh A, del Carmen M, Penson R, Birrer MJ. Ovarian cancer: markers of response.Int J Gynecol
Cancer. 2009; 19 Suppl 2 :S21-S29.
Nikiforova MN, Nikiforov YE. Molecular diagnostics and predictors in thyroid cancer.Thyroid. 2009; 19 (12) :1351-1361.
O'Toole D, Grossman A, Gross D, Delle Fave G, Barkmanova J, O'Connor J, Pape UF, Plockinger
U. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: biochemical
markers.Neuroendocrinology. 2009; 90 (2) :194-202.
Ringel MD. Molecular markers of aggressiveness of thyroid cancer.Curr Opin Endocrinol Diabetes Obes. 2009; 16 (5)
:361-366.

ARUP LABORATORIES | 500 Chipeta Way | Salt Lake City, Utah 84108-1221 | (800) 522-2787 | www.arupconsult.com | www.aruplab.com
© 2006–2011 ARUP Laboratories. All Rights Reserved. Tumor Markers - p. 51 of 54
The Physician's Guide to Laboratory Test Selection and Interpretation

Rodriguez H, Tezak Z, Mesri M, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Philip
R, Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E. Analytical validation of protein-based multiplex
assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.Clin Chem.
2010; 56 (2) :237-243.
Tzankov A, Zlobec I, Went P, Robl H, Hoeller S, Dirnhofer S. Prognostic immunophenotypic biomarker studies in
diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores.Leuk Lymphoma. 2010;
51 (2) :199-212.

References from the ARUP Institute for Clinical and Experimental Pathology®
Bahler DW, Szankasi P, Kulkarni S, Tubbs RR, Cook JR, Swerdlow SH. Use of similar immunoglobulin VH gene
segments by MALT lymphomas of the ocular adnexa.Mod Pathol. 2009; 22 (6) :833-838.
Chernock RD, Perry A, Pfeifer JD, Holden JA, Lewis JS Jr. Receptor tyrosine kinases in sinonasal undifferentiated
carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression.Head Neck. 2009; 31 (7) :919-927.
Lim MS, Carlson ML, Crockett DK, Fillmore GC, Abbott DR, Elenitoba-Johnson OF, Tripp SR, Rassidakis GZ,
Medeiros LJ, Szankasi P, Elenitoba-Johnson KS. The proteomic signature of NPM/ALK reveals deregulation of
multiple cellular pathways.Blood. 2009; 114 (8) :1585-1595.
Margraf RL, Calderon FR, Mao R, Wittwer CT. RET mutation scanning update: exon 15.Clin Chem. 2009; 55 (11)
:2059-2061.
Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He X, Hu Z, Quackenbush JF,
Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS. Supervised risk
predictor of breast cancer based on intrinsic subtypes.J Clin Oncol. 2009; 27 (8) :1160-1167.
Poirel HA, Cairo MS, Heerema NA, Swansbury J, Auperin A, Launay E, Sanger WG, Talley P, Perkins SL, Raphael
M, McCarthy K, Sposto R, Gerrard M, Bernheim A, Patte C. Specific cytogenetic abnormalities are associated with a
significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the
FAB/LMB 96 international study.Leukemia. 2009; 23 (2) :323-331.
Slattery ML, Wolff RK, Herrick J, Caan BJ, Samowitz W. Tumor markers and rectal cancer: support for an
inflammation-related pathway.Int J Cancer. 2009; 125 (7) :1698-1704.

Reviewed by
Bahler, David W., MD, PhD. Medical Director, Hematologic Flow Cytometry at ARUP Laboratories; Associate
Professor of Pathology, University of Utah
Grenache, David G., PhD. Medical Director, Special Chemistry at ARUP Laboratories; Associate Professor of
Pathology (Clinical), University of Utah
Jarboe, Elke, MD. Assistant Medical Director, Immunohistochemistry and Cytopathology R&D at ARUP Laboratories;
Assistant Professor, Anatomic Pathology, University of Utah
Kelley, Todd, MD, MS. Co-Medical Director, Molecular Hematopathology at ARUP Laboratories; Assistant Professor of
Pathology, University of Utah
Layfield, Lester, MD. Fine-Needle Aspiration Services and Molecular Diagnostics at ARUP Laboratories; Professor
and Head, Surgical Pathology, University of Utah
Mao, Rong, MD. Medical Director, Molecular Genetics, Fragment Analysis and Sequencing at ARUP Laboratories;
Assistant Professor of Pathology (Clinical), University of Utah
Meikle, A. Wayne, MD. Medical Director, RIA and Endocrinology at ARUP Laboratories; Professor of Internal Medicine
and Pathology, University of Utah
Prchal, Josef T., MD. Medical Director, Special Genetics at ARUP Laboratories; Professor of Hematology, Pathology
and Genetics, University of Utah
Roberts, William L., MD, PhD. Medical Director, Automated Core Laboratory at ARUP Laboratories; Professor of
Pathology, University of Utah

ARUP LABORATORIES | 500 Chipeta Way | Salt Lake City, Utah 84108-1221 | (800) 522-2787 | www.arupconsult.com | www.aruplab.com
© 2006–2011 ARUP Laboratories. All Rights Reserved. Tumor Markers - p. 52 of 54
The Physician's Guide to Laboratory Test Selection and Interpretation

Samowitz, Wade S., MD. Medical Director, AP Oncology at ARUP Laboratories; Professor of Pathology, University of
Utah
South, Sarah T., PhD. Medical Director, Cytogenetics and Molecular Cytogenetics at ARUP Laboratories; Assistant
Professor, Department of Pediatrics, Adjunct Professor, Department of Pathology, University of Utah

Related Content
Acute Lymphoblastic Leukemia - ALL
Acute Myeloid Leukemia - AML
Bladder Cancer
Breast Cancer
Carcinoid Tumors
Central Nervous System Tumors - Brain Tumors
Cervical Cancer
Chronic Lymphocytic Leukemia - CLL
Chronic Myelogenous Leukemia - CML
Colorectal Cancer
Ewing Sarcoma
Glucagonoma
Hepatocellular Carcinoma
Human Papillomavirus - HPV
Insulinoma
Lung Cancer
Lymphoma Phenotyping
Lymphomas, B-Cell - B-Cell Lymphomas
Lymphomas, T/NK-Cell - T/NK-Cell Lymphomas
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Melanoma
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Multiple Endocrine Neoplasias - MEN
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Neuroblastoma
Neuropathic Disease
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Pancreatic Cancer
Pancreatic Neuroendocrine Tumors - NET
Paraneoplastic Neurological Syndromes
Pheochromocytoma

ARUP LABORATORIES | 500 Chipeta Way | Salt Lake City, Utah 84108-1221 | (800) 522-2787 | www.arupconsult.com | www.aruplab.com
© 2006–2011 ARUP Laboratories. All Rights Reserved. Tumor Markers - p. 53 of 54
The Physician's Guide to Laboratory Test Selection and Interpretation

Plasma Cell Dyscrasias


Prostate Cancer - PSA
Sarcoma
Somatostatinoma
Sézary Syndrome
Testicular Cancer
Thyroid Cancer
Vasoactive Intestinal Polypeptide Secreting Tumor - VIPoma
Zollinger-Ellison Syndrome - Gastrinoma

Comprehensive Review: December 2010


Last Update: May 2011

ARUP LABORATORIES | 500 Chipeta Way | Salt Lake City, Utah 84108-1221 | (800) 522-2787 | www.arupconsult.com | www.aruplab.com
© 2006–2011 ARUP Laboratories. All Rights Reserved. Tumor Markers - p. 54 of 54