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What is Ogilvie

1. Ogilvie, H. (1948). Large-intestine colic due to sympathetic deprivation. British Medical
Journal, 2(4579), 671.
2. Ross, S. W., Oommen, B., Wormer, B. A., Walters, A. L., Augenstein, V. A., Heniford,
B. T., ... & Christmas, A. B. (2016). Acute Colonic Pseudo-obstruction: Defining the
Epidemiology, Treatment, and Adverse Outcomes of Ogilvie’s Syndrome. The American
Surgeon, 82(2), 102-111.
a. Largest study to date on acpo
3. Jain, A., & Vargas, H. D. (2012). Advances and challenges in the management of acute
colonic pseudo-obstruction (ogilvie syndrome). Clinics in colon and rectal surgery,
25(01), 037-045.
a. overview
Hypokalemia in Ogilvie – mechanism plus secretory diarrhea

1. Sunnoqrot, N., & Reilly, R. F. (2015). Hypokalemia associated with colonic pseudo-
obstruction (Ogilvie's Syndrome). Case reports in nephrology and dialysis, 5(2), 118-
123.
a. Has diagram with upregulation of bk receptor
2. van Dinter, T. G., Fuerst, F. C., Richardson, C. T., Santa Ana, C. A., Polter, D. E.,
Fordtran, J. S., & Binder, H. J. (2005). Stimulated active potassium secretion in a patient
with colonic pseudo-obstruction: a new mechanism of secretory diarrhea.
Gastroenterology, 129(4), 1268-1273.
a. Secretory vs classic diarrhea ?
3. Bazerbachi, F., Haffar, S., Wang, Z., Schneider, S. L., Nehra, V., Szarka, L. A., &
Camilleri, M. (2017). Secretory Diarrhea and Hypokalemia Associated with Acute
Colonic Pseudo-Obstruction: A Systematic Review and Meta-analysis of the Literature.
Gastroenterology, 152(5), S512-S513.
Treatment of Ogilvies and hypokalemia

1. Ram, P., Goyal, A., Lu, M., Sloan, J., & McElhaugh, W. (2016). Use of Aldosterone
Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s Syndrome. Case reports in
gastrointestinal medicine, 2016.
2. Ponec, R. J., Saunders, M. D., & Kimmey, M. B. (1999). Neostigmine for the treatment
of acute colonic pseudo-obstruction. New England Journal of Medicine, 341(3), 137-141.
3. Valle, R. G. L., & Godoy, F. L. (2014). Neostigmine for acute colonic pseudo-
obstruction: a meta-analysis. Annals of Medicine and Surgery, 3(3), 60-64.

decreased ganglion cells in colonic smooth muscles . dysregulation of stretch receptors.Risk stratification: male. retrospective of more than 100.000 pts over 14 yrs .What is Ogilvie Ross et al: largest study to date. comorbid patients.Pathophys: inhibition of parasympathetic activity. requiring colonoscopy = greater odds of inpatient mortality - .Epidemiology: . emergent admissions. older.