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Pulmonary Tuberculosis Pathophysiology & Schematic Diagram

Over Poorly Poor Mal Inadequate Emotional Chronic Medical Inadequate Immuno Old Young
Crowding Sanitized Hygiene nutrition Physical & Physical Diseases & Surgical Immunization Suppressant Age People
Environment Barriers Stressors (DM, athero) Treatments Drugs (corticosteroids)

Close offers inhibits enables increased impaired depressed de- im-


Contact an produc- pathogen cortisol blood flow bone reduces decreases inhibits creasing mature
to environ tion of to gain activity marrow levels Immuno- inter- thymus immune
TB -ment anti- access to production of: globulin leukin function system
patient for bodies the body binding to synth m
bacteria decreased impaired cell
to level of blood flow & surface
impaired
colonize leukocytes nutrient receptors
increased leuko- leuko- mono- im-
delivery to cytosis
exposure cytes & cytes paired
systems
to pathogens eosino- activatn
phils of B
decreased cells,
impaired diminished phago- cyto-
immune cytotoxicity cytosis toxic T
im- de-
response of natural cells,
paired creased
to immuni- killer cells natural
release phago-
zation killer
of hista- cytosis
cells,
mines,
macro-
brady-
phages
kinin &
and
prosta-
other
glandins cells of
the
immune
system

infected person sneezes and coughs/ transmits microorganism

Droplets Droplets Droplets


remain settle to infect
suspend surfaces cattle
ed in the
air are
spread
by air
currents

weakened defense system


person inhales person
the droplets ingests
food
increased susceptibility to infection

Mycobacterium tuberculosis infection

Bacteria is transmitted to the airways

PULMONARY TUBERCULOSIS

deposition in the alveoli