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Contemporary medicine is in general conducted within health care

systems. Legal, credentialing and financing frameworks are
established by individual governments, augmented on occasion by
international organizations, such as churches. The characteristics of
any given health care system have significant impact on the way
medical care is provided.
From ancient times, Christian emphasis on practical charity gave rise
to the development of systematic nursing and hospitals and the
Catholic Church today remains the largest non-government provider
of medical services in the world.[15] Advanced industrial countries (with
the exception of the United States)[16][17] and many developing
countries provide medical services through a system of universal
health care that aims to guarantee care for all through a single-payer
health care system, or compulsory private or co-operative health
insurance. This is intended to ensure that the entire population has
access to medical care on the basis of need rather than ability to pay.
Delivery may be via private medical practices or by state-owned
hospitals and clinics, or by charities, most commonly by a
combination of all three.
Most tribal societies provide no guarantee of healthcare for the
population as a whole. In such societies, healthcare is available to
those that can afford to pay for it or have self-insured it (either directly
or as part of an employment contract) or who may be covered by care
financed by the government or tribe directly.

Modern drug ampoules
Transparency of information is another factor defining a delivery
system. Access to information on conditions, treatments, quality, and
pricing greatly affects the choice by patients/consumers and,
therefore, the incentives of medical professionals. While the US
healthcare system has come under fire for lack of openness,[18] new
legislation may encourage greater openness. There is a perceived
tension between the need for transparency on the one hand and such
issues as patient confidentiality and the possible exploitation of
information for commercial gain on the other.
See also: Health care, clinic, hospital, and hospice

Provision of medical care is classified into primary. Papua New Guinea Primary care medical services are provided by physicians.' They are in the patient's own words and are recorded along with the duration of each one. what the patient actually does. injuries. East New Britain. About 90% of medical visits can be treated by the primary care provider. or other health professionals who have first contact with a patient seeking medical treatment or care. home visits. nursing homes. and home remedies. history of known allergies. These occur in physician offices.  Past medical history (PMH/PMHx): concurrent medical problems. and tertiary care categories. and other places close to patients. schools. The components of the medical interview[10] and encounter are:  Chief complaint (CC): the reason for the current medical visit. These include treatment of acute and chronic illnesses. Medical history comprises HPI and PMH. . past hospitalizations and operations. often called past medical history (PMH). hobbies. Nurses in Kokopo. Allergies are also recorded. These are the 'symptoms. clinics. physician assistants. past infectious diseases or vaccinations.  History of present illness (HPI): the chronological order of events of symptoms and further clarification of each symptom. Also called 'chief concern' or 'presenting complaint'. secondary.  Medications (Rx): what drugs the patient takes including prescribed. as well as alternative and herbal medicines/herbal remedies. Distinguishable from history of previous illness. preventive care and health education for all ages and both sexes.  Current activity: occupation. over-the-counter. nurse practitioners.

the process may be repeated in an abbreviated manner to obtain any new history. followed by questions on the body's main organ systems (heart. may place barriers on accessing expensive services. various forms of "utilization review". It is to likely focus on areas of interest highlighted in the medical history and may not include everything listed above. alcohol).. and lab or imaging results or specialist consultations. which may be missed on HPI: a general enquiry (have you noticed any weight loss. Social history (SH): birthplace.[14] The medical decision-making (MDM) process involves analysis and synthesis of all the above data to come up with a list of possible diagnoses (the differential diagnoses).  Review of systems (ROS) or systems inquiry: a set of additional questions to ask. body temperature. tobacco. respiration rate. and sometimes smell (e. symptoms. Follow-up may be advised. pallor or clubbing)  Skin  Head. and throat (HEENT)  Cardiovascular (heart and blood vessels)  Respiratory (large airways and lungs)  Abdomen and rectum  Genitalia (and pregnancy if the patient is or could be pregnant)  Musculoskeletal (including spine and extremities)  Neurological (consciousness. blood pressure. On subsequent visits. palpation (feel). generally in that order although auscultation occurs prior to percussion and palpation for abdominal assessments. nose. such as prior authorization of tests. Depending upon the health insurance plan and the managed care system. along with an idea of what needs to be done to obtain a definitive diagnosis that would explain the patient's problem. referral to a specialist. hearing. evidence of abnormal perception or thought). lungs. touch. The treatment plan may include ordering additional medical laboratory tests and medical imaging studies. diabetic ketoacidosis).). urinary tract. spinal cord and peripheral nerves)  Psychiatric (orientation. residences. physical findings. weight.  Family history (FH): listing of diseases in the family that may impact the patient. presence of jaundice. and hemoglobin oxygen saturation  General appearance of the patient and specific indicators of disease (nutritional status. marital history. ear. percussion (tap to determine resonance characteristics).g.[13] The clinical examination involves the study of:  Vital signs including height. etc. lumps and bumps? etc. in contrast to symptoms which are volunteered by the patient and not necessarily objectively observable. fevers. starting therapy. vision. awareness.). A family tree is sometimes used. and auscultation (listen). The physical examination is the examination of the patient for medical signs of disease. in infection. uremia. mental state. medications. Four actions are the basis of physical examination: inspection. social and economic status. or watchful observation. cranial nerves. habits (including diet. which are objective and observable. . digestive tract.[12] The healthcare provider uses the senses of sight. eye. brain. change in sleep quality. pulse.

and medical . see Pharmaceutical drug. see Medicine (disambiguation). Medicine Statue of Asclepius. biomedical research. medic Medicine is the science and practice of the diagnosis. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. holding the symbolic Rod of Asclepius with its coiled serpent Specialist Physician. "Academic medicine" redirects here. treatment. genetics. and prevention of disease. Contemporary medicine applies biomedical sciences. the Greek god of medicine. see Academic Medicine (journal). For the journal. For other uses. For medicaments.his article is about the science and art of healing.

under the umbrella of medical science).[citation needed] ACTH also stimulates the adrenal cortex to release cortisol. and other tumors of the sympathetic ganglia. some minute dilution. external splints and traction. but also through therapies as diverse as psychotherapy.[1] Medicine has existed for thousands of years. In recent centuries. stimulates the release of adrenaline. the knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science. biologics. While stitching technique for sutures is an art learned through practice. For example.[74] Unlike many other hormones adrenaline (as with other catecholamines) does not exert negative feedback to down-regulate its own synthesis. They remain commonly used with or instead of scientific medicine and are thus called alternative medicine. Calcium triggers the exocytosis of chromaffin granules and. and metabolism by monoamine oxidase and catechol-O-methyl transferase. such as surreptitious epinephrine administration. enhancing adrenaline synthesis. since the advent of modern science. medical devices. during most of which it was an art (an area of skill and knowledge) frequently having connections to the religious and philosophical beliefs of local culture. treat. most medicine has become a combination of art and science (both basic and applied.[73] Adrenocorticotropic hormone (ACTH) and the sympathetic nervous system stimulate the synthesis of adrenaline precursors by enhancing the activity of tyrosine hydroxylase and dopamine β-hydroxylase. or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. the release of adrenaline (and noradrenaline) into the bloodstream. amongst others. typically through pharmaceuticals or to diagnose. causing cell depolarization and an influx of calcium through voltage-gated calcium channels. Prescientific forms of medicine are now known as traditional medicine and folk medicine. For example.[citation needed] The sympathetic nervous system. evidence on the effectiveness of acupuncture is "variable and inconsistent" for any condition. Its action is terminated with reuptake into nerve terminal endings. treatments outside the bounds of safety and efficacy are termed quackery. Contents [hide] temperature. and ionizing radiation.[3] In contrast. which increases the expression of PNMT in chromaffin cells. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors. acting via splanchnic nerves to the adrenal medulla.[2] but is generally safe when done by an appropriately trained practitioner.[75]Abnormally elevated levels of adrenaline can occur in a variety of conditions. a medicine man would apply herbs and say prayers for healing. . thus. This is most often done in response to stress. and prevent injury and disease. pheochromocytoma. All of these stimuli are processed in the central nervous system. two key enzymes involved in catecholamine synthesis.

there are stories of a parent lifting part of a car when their child is trapped underneath.[85][86] vary by tissue type and tissue expression of adrenergic receptors.[81] Such activities include extreme and risky sports. unsafe sex. adrenaline infusion alone does increase alertness[84] and has roles in the brain including the augmentation of memory consolidation.[80] Adrenaline was first synthesized in the laboratory by Friedrich Stolz and Henry Drysdale Dakin. high levels of epinephrine causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles.[76] American ophthalmologist William H. legal or financial risk". including the major subtypes α1. independently.[60] and stimulates glycolysis and inhibits insulin-mediated glycogenesis in muscle.[82]:147–8 Strength[edit] Main article: Hysterical strength Adrenaline has been implicated in feats of great strength. and crime. it may not drive behavior. β2. The term relates to the increase in circulating levels of adrenaline during physiological stress. and β3. α2. so while the circulating adrenaline concentration is present. For example.[83] Although such stress triggers adrenaline release.[82] Such an increase in the circulating concentration of adrenaline is secondary to activation of the sympathetic nerves innervating the adrenal medulla. Takamine successfully isolated and purified the hormone from the adrenal glands of sheep and oxen. in 1904. These extracts.[78][79] In 1901. Nevertheless. social.History[edit] Main article: History of catecholamine research Extracts of the adrenal gland were first obtained by Polish physiologist Napoleon Cybulski in 1895.[79] Society and culture[edit] Adrenaline junkie[edit] See also: Novelty seeking An adrenaline junkie is somebody who engages in sensation-seeking behavior through "the pursuit of novel and intense experiences without regard for physical. stimulates glycogenolysis in the liver and muscle. For example. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas. Epinephrine acts by binding to a variety of adrenergic receptors. as it is rapid and not present in animals where the adrenal gland has been removed.[61][62] β adrenergic receptor binding triggers glucagon secretion . Bates discovered adrenaline's usage for eye surgeries prior to 20 April 1896. it also activates many other responses within the central nervous system reward system which drives behavioral responses.[77] Japanese chemist Jokichi Takamine and his assistant Keizo Uenaka independently discovered adrenaline in 1900. often occurring in times of crisis. substance abuse.[59] Epinephrine's binding to these receptors triggers a number of metabolic changes. β1. Epinephrine is a nonselective agonist of all adrenergic receptors. which he called nadnerczyna("adrenalin"). contained adrenaline and other catecholamines.

[62] Its actions are to increase peripheral resistance via α1 receptor- dependent vasoconstriction and to increase cardiac output via its binding to β1 receptors. but may increase by 10-fold during exercise and by 50-fold or more during times of stress. these effects lead to increased blood glucose and fatty acids. plasma or serum as a diagnostic aid.000 ng/L.[64] Measurement in biological fluids[edit] Epinephrine may be quantified in blood. Together. to monitor therapeutic administration. The goal of reducing peripheral circulation is to increase coronary and cerebral perfusion pressures and therefore increase oxygen exchange at the cellular level. or to identify the causative agent in a potential poisoning victim. providing substrates for energy production within cells throughout the body. cerebral. Endogenous plasma epinephrine concentrations in resting adults are normally less than 10 ng/L. and carotid circulation pressure.[63] While epinephrine does increase aortic. Pheochromocytoma patients often have plasma adrenaline levels of 1000–10. Parenteral administration of epinephrine to acute-care cardiac patients can produce plasma concentrations of 10. It appears that epinephrine may be improving macrocirculation at the expense of the capillary beds where actual perfusion is taking place.000 to the pancreas.[65][66] Biosynthesis and regulation[edit] . increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. and increased lipolysis by adipose tissue.000 ng/L. it lowers carotid blood flow and end-tidal CO2 or ETCO2 levels.

epinephrine is one of a group of monoamines called the catecholamines. It is produced in some neurons of the central nervous system. The biosynthesis of adrenaline involves a series of enzymatic reactions. and in the chromaffin cells of the adrenal . In chemical terms.

This trimeric G protein dissociates to Gs alpha and Gs beta/gamma subunits. VMAT1 is also responsible for transporting newly synthesized adrenaline from the cytosol back into chromaffin granules in preparation for release.[50][51] Benign familial tremor (BFT) is responsive to peripheral β adrenergic blockers and β2- stimulation is known to cause tremor. which is subsequently decarboxylated to give dopamine.[69] For noradrenaline to be acted upon by PNMT in the cytosol. there must be some autonomy of the adrenal medulla from the rest of the sympathetic system. as with Addisons disease. Tyrosine is first oxidized to L-DOPA. Myocardial infarction is associated with high levels of circulating epinephrine and norepinephrine. which changes conformation and helps Gs. but not norepinephrine.[52][53] Low. Gs beta/gamma binds to the calcium channel and allows calcium ions to enter the cytoplasm. but there is selectivity during hypoxia and hypoglycaemia. particularly in cardiogenic shock. Cyclic AMP binds to the regulatory subunit of protein kinase A: Protein kinase A phosphorylates phosphorylase kinase. Gs alpha binds to adenyl cyclase. a protein present in all eukaryotic cells. or absent. Patients with BFT were found to have increased plasma epinephrine. phenylethanolamine-N-methyltransferase. which then phosphorylates glycogen and converts it to glucose-6-phosphate. a G protein. which then binds to phosphorylase kinase and finishes its activation. Oxidation gives norepinephrine. Meanwhile.[citation needed] Pathology[edit] Increased epinephrine secretion is observed in pheochromocytoma. can suppress epinephrine secretion as the activity of the synthesing enzyme. adrenaline binds to the β adrenergic receptor. exchange GDP to GTP. it has been detected at low levels in both the heart and brain. This reaction is catalyzed by the enzyme phenylethanolamine N-methyltransferase (PNMT) which utilizes S- adenosyl methionine (SAMe) as the methyl donor. thus converting ATP into cyclic AMP.[68] While PNMT is found primarily in the cytosol of the endocrine cells of the adrenal medulla (also known as chromaffin cells).[67] Epinephrine is synthesized in the medulla of the adrenal gland in an enzymatic pathway that converts the amino acid tyrosine into a series of intermediates and. it must first be shipped out of granules of the chromaffin cells. Failure of the adrenal cortex. The final step in epinephrine biosynthesis is the methylation of the primary amine of norepinephrine. This may occur via the catecholamine- H+ exchanger VMAT1.medulla from the amino acids phenylalanine and tyrosine. when the ratio of adrenaline to noradrenaline is considerably increased. Phosphorylase kinase phosphorylates glycogen phosphorylase. Calcium ions bind to calmodulin proteins.[46] In liver cells.[54][55][56] . concentrations of epinephrine can be seen in autonomic neuropathy or following adrenalectomy. depends on the high concentration of cortisol that drains from the cortex to the medulla. myocardial infarction and to a lesser degree in benign essential familial tremor. ultimately. A general increase in sympathetic neural activity is usually accompanied by increased adrenaline secretion. hypoglycemia.[47][48][49] Therefore. epinephrine.

[57] The British Approved Name and European Pharmacopoeia term for this drug is adrenaline and is indeed now one of the few differences between the INN and BAN systems of names. The major emotion studied in relation to epinephrine is fear. which was trademarked by Parke. the term epinephrine is used over adrenaline. the greater amount of epinephrine is positively correlated with an arousal state of negative feelings. and called it "adrenalin" (from the Latin for "on top of the kidneys"). Jokichi Takamine patented a purified adrenal extract. pharmaceuticals that mimic the effects of epinephrine are often called adrenergics. epinephrine became[when?] the generic name in the U. However.[57] In the belief that Abel's extract was the same as Takamine's.[43] There is evidence that suggests epinephrine does have a role in long-term stress adaptation and emotional memory encoding specifically. contributing to higher levels of arousal due to fear. and receptors for epinephrine are called adrenergic receptors or adrenoceptors. a belief since disputed. These findings can be an effect in part that epinephrine elicits physiological sympathetic responses including an increased heart rate and knee shaking. The hormonal component includes the release of epinephrine.S. ensuring memory strength that is proportional to memory importance.[41] The findings from this study demonstrate that there are learned associations between negative feelings and levels of epinephrine. such as epinephrine. Epinephrine may also play a role in elevating arousal and fear memory under particular pathological conditions including post-traumatic stress disorder. Findings support the idea that epinephrine does have a role in facilitating the encoding of emotionally arousing events. Emotional response[edit] Every emotional response has a behavioral component.[42] Overall.[58] Among American health professionals and scientists. Davis & Co in the U.Terminology[edit] Epinephrine is the pharmaceutical's United States Adopted Name and International Nonproprietary Name. subjects did not express a greater amusement to an amusement film nor greater anger to an anger film. In the same study. can modulate memory consolidation of the events. The term epinephrine was coined by the pharmacologist John Abel (from the Greek for "on top of the kidneys"). subjects who were injected with epinephrine expressed more negative and fewer positive facial expressions to fear films compared to a control group. who used the name to describe the extracts he prepared from the adrenal glands as early as 1897. and a hormonal component. The release of epinephrine due to emotionally stressful events. which is endogenous epinephrine. an autonomic component. In an experiment. though the name adrenaline is frequently used. Post-learning epinephrine activity also interacts with the degree of arousal associated with the initial coding.[41] Similar findings were also supported in a study that involved rodent subjects that either were able or unable to produce epinephrine.[57] In 1901. which can be attributed to the feeling of fear regardless of the actual level of fear elicited from the video. an adrenomedullary response that occurs in response to stress and that is controlled by the sympathetic nervous system. can produce retrograde enhancement of long-term memory in humans. other emotions have not had such results. Although studies have found a definite relation between epinephrine and fear. These subjects also reported a more intense fear from the films and greater mean intensity of negative memories than control subjects.S. "Extensive evidence indicates .[42] Memory[edit] It has been found that adrenergic hormones. Overall.

[13][14][15] Pharmacological doses of epinephrine stimulate α1. that epinephrine (EPI) modulates memory consolidation for emotionally arousing tasks in animals and human subjects.[17][18] Epinephrine does have a β2 adrenoceptor-mediated effect on metabolism and the airway. mostly in scattered chromaffin cells. rather than epinephrine.[27] Although much valuable work has been published using fluorimetric assays to measure total catecholamine concentrations. β1.[23][24] Exercise[edit] One physiological stimulus to epinephrine secretion is exercise. fight and fright response was originally proposed by Cannon. This was first demonstrated using the denervated pupil of a cat as an assay. max-width: 100%. Following adrenalectomy. epinephrine disappears below the detection limit in the blood stream.[26] Biochemical methods for measuring catecholamines in plasma were published from 1950 onwards. and β3 adrenoceptors of the sympathetic nervous system. so its effects on memory consolidation are at least partly initiated by β adrenoceptors in the periphery. most of which is a spill over from neurotransmission with little activity as a hormone. he adrenal medulla is a minor contributor to total circulating catecholamines(L-DOPA is at a higher concentration in the plasma). FDA Orange Book 1.[45] These findings suggest that β adrenoceptors are necessary for epinephrine to have an effect on memory consolidation. based on their responsiveness to adrenaline.[44]Epinephrine does not readily cross the blood–brain barrier. Little epinephrine is found in other tissues. In adrenalectomized patients hemodynamic and metabolic responses to stimuli such as hypoglycemia and exercise remain normal.[12] The adrenal glands contribute about 7% of circulating norepinephrine. α2."> Prescription Drug Products: 1 of 12 (RX Drug Ingredient) . Studies have found that sotalol. there being no direct neural connection from the sympathetic ganglia to the airway.[11] though it contributes over 90% of circulating epinephrine.[16] The term "adrenergic" is often misinterpreted in that the main sympathetic neurotransmitter is norepinephrine (noradrenaline). overflow-x: auto.[19][20][21] The concept of the adrenal medulla and the sympathetic nervous system being involved in the flight. as discovered by Ulf von Euler in 1946. Sympathetic nerve receptors are classified as adrenergic.”[44] Studies have also found that recognition memory involving epinephrine depends on a mechanism that depends on β adrenoceptors. blocks the enhancing effects of peripherally administered epinephrine on memory. width: 598.[25] later confirmed using a biological assay on urine samples.[22] But the adrenal medulla. a β adrenoceptor antagonist that also does not readily enter the brain. the method is too non- specific and insensitive to accurately determine the very small quantities of epinephrine in plasma. β2. is not required for survival. padding: 1em 1px 0.2em. Prescription Drug Products <="" div="" style="box-sizing: border-box.59375px. in contrast to the adrenal cortex.

HOSPIRA (Application Number: A088571) Applicant 4. HOSPIRA (Application Number: A089651) from FDA Orange Book <="" div="" style="box-sizing: border-box. max-width: 100%."> Prescription Drug Products: 2 of 12 (RX Drug Ingredient) Drug Ingredient EPINEPHRINE.59375px.Prescription Drug Products: 1 of 12 (RX Drug Ingredient) Drug Ingredient EPINEPHRINE Proprietary Name EPIPEN MYLAN SPECIALITY LP (Application Number: N019430. EASTMAN KODAK (Application Number: A040057) 2. HOSPIRA (Application Number: A089644) 6. HOSPIRA (Application Number: A078772) 3. padding: 1em 1px 0. overflow-x: auto."> Prescription Drug Products: 3 of 12 (RX Drug Ingredient) Drug Ingredient EPINEPHRINE. 9586010) from FDA Orange Book <="" div="" style="box-sizing: border-box. width: 598. and . HOSPIRA (Application Number: A089645) 7.2em.59375px. 8870827. width: 598. LIDOCAINE HYDROCHLORIDE Proprietary Name XYLOCAINE W/ EPINEPHRINE FRESENIUS KABI USA (Application Applicant Number: N006488) FDA Pharm Classes Epinephrine Hydrochloride is the hydrochloride salt of the naturally occurring sympathomimetic amine with vasoconstricting.2em. padding: 1em 1px 0. intraocular pressure-reducing. overflow-x: auto. 7794432. HOSPIRA (Application Number: A089635) 5. LIDOCAINE HYDROCHLORIDE LIDOCAINE Proprietary Name HYDROCHLORIDE AND EPINEPHRINE 1. Applicant Patents: 7449012. max-width: 100%. 8048035. HOSPIRA (Application Number: A089646) 8.

ale pak už Benda nepřišel na žádnou obvyklou schůzku. Totiž druhého září se nestalo docela nic. ale jelikož na tom nebylo nic neobvyklého. copak se s vámi stalo?” vyhrkl doktor užasle. Ale od té doby nebylo po herci Bendovi ani památky. co se děje s Bendou. To bylo totiž tak: Doktor Goldberg byl. který k němu choval přátelské opovržení a s jistou blahosklonností mu dovoloval. tihle herci. “A. řekl si konečně doktor Goldberg a zajel si jednou večer do Bendova bytu. když Benda nepřišel ani na třetí zkoušku. že už ho sám po celý týden shání po všech nočních lokálech a výletních hotelech s rostoucím znepokojením. to jste vy. . Ten doktor Goldberg byl chirurg a vydělával ukrutné peníze na slepých střevech. hořel pro umění. které byly druhou stránkou proslulosti velkého mima. Tu drnčel doktor dobrých pět minut na zvonek.bronchodilating activities. and a lowering of intraocular pressure. to už je taková židovská specialita. kde se začínaly zkoušky na Krále Leara. dala byt svým sumárním způsobem do pořádku a šla zase po svém. posluhovačka. poslední. Bendovu příteli. Ale desátého září se strhla po herci Bendovi sháňka. epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle. že nemá ponětí. co neřekl. měl přijít do divadla. jenom pan mistr nebyl doma. Tedy tomu doktoru Goldbergovi telefonovali z divadla. a decrease in the production of aqueous humor. this agent binds to alpha- adrenergic receptors in the iris sphincter muscle. “co chcete?” “Proboha. neví-li. Zvonil u dveří. Tragická maska Bendova a zářící obličej doktora Goldberga (který pil jenom vodu). mezi námi. resulting i MIZENÍ HERCE BENDY Druhého září zmizel herec Benda. Odpověděl. thereby increasing vascular resistance and blood pressure. který obyčejně Bendu obklopoval. kam zas jel hrát nebo flámovat. zdál se přepadlý a špinavý. to už patřilo k sobě při všech těch sardanapalských flámech a divokých výtržnostech. epinephrinecauses vasoconstriction. měl tísnivou předtuchu. mistr Jan Benda. vzbudilo to přece jen nepokoj a z divadla telefonovali doktoru Goldbergovi. Snad stůně. aby za něj platil. nikdo nešel otevřít. což. Jinak to byl tlustý člověk s tlustými zlatými brýlemi a tlustým zlatým srdcem. kdopak ví. resulting in vasoconstriction. že se něco Bendovi stalo. našla zválenou postel a celý ten kančí nepořádek. to vám je jako cikáni. co prý se děje s Bendou. Dobrá. jak se mu říkalo od té doby. By stimulating vascular alpha-adrenergic receptors. bylo. ale že se po něm podívá. prosím vás. ale uvnitř bylo slyšet nějaký šramot. nebyla zrovna maličkost. kdo Jana Bendu viděl. bylo to právě prvního září. co jediným rozběhem vystoupil na jednu z nejvyšších příčlí herecké slávy. která v devět hodin ráno přišla poklidit Bendův byt. měl byt od podlahy po strop ověšený samými obrazy a oddaně miloval herce Bendu. Někdy koncem srpna s ním ještě podnikl triumfální tažení noční Prahou. stál v nich Benda zahalený v županu.” řekl nevlídně. Paní Marešová (totiž ta posluhovačka) se nepodivila příliš ani tomu. pokud mohl zjistit. najednou zazněly kroky a dveře se otevřely. Through its beta1 receptor-stimulating actions. When administered in the conjunctiva. a doktor Goldberg se ho zděsil: tak zdivočele vypadal slavný herec s rozcuchanými a slepenými vlasy a vousy dobrý týden neholenými.