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11 Health Benefits of Grape Seed Extract(1), You Probably

Don't Know, According to Online Herbal Medical Literature

Kyle J. Norton

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae,
native to southern Turkey.
A. Quoted From The World Most Popular Herbs

Grape Seed Extract is the commercial extracts from whole grape seeds that
contains many concentrations, including vitamin E, flavonoids, linoleic acid,
oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional
medicine as antioxidant, anti-inflammatory agents and to treat skin wounds
with less scarring, allergies, macular degeneration, arthritis, enhance circulation
of blood vessels, lower cholesterol, etc.

1. Ulcer
in the comparison of effects of Grape Seed Extract (GSE) and vitamins C and E
on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid
peroxidation in rats, found that GSE protected against ethanol-induced gastric
ulcers more effectively than VC or VE, while its protection against aspirin
ulcers was comparable for all treatments. GSE produced the greatest reductions
of gastric MDA in both models, according to" Effects of grape seed extract,
vitamin C, and vitamin e on ethanol- and aspirin-induced ulcers" by Cuevas
VM, Calzado YR, Guerra YP, Yera AO, Despaigne SJ, Ferreiro RM, Quintana
DC.(1)

2. Pulmonary fibrosis
in assessment of grape seed extract (GSE) or vitamin E (Vit E) as antioxidants
in effecting oxidative stress implication in the pathogenesis of silica-induced
lung fibrosis indicated that according to the results of this study GSE could
reduce the fibrogenic effect of silica. However; no synergistic effect was
observed after co-administration of GSE and Vit E, according to "A
comparative study of grape seed extract and vitamin E effects on silica-induced
pulmonary fibrosis in rats" by Hemmati AA, Nazari Z, Samei M.(2)

3. Liver protective effect
In the observation of the efficacy of methotrexate (MTX), a widely used
cytotoxic chemotherapeutic agent, and its liver protective effect found that GSE
was supplemented, no significant changes in blood count parameters were
noted. It appears that GSE protects the rat liver and inhibits methotrexate-
induced oxidative stress. These data indicate that GSE may be of therapeutic
benefit when used with MTX, according to "Role of grape seed extract on
methotrexate induced oxidative stress in rat liver" by Cetin A, Kaynar L,
Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, Sari I, Sagdic O.(3)

4. Antioxidant Activity
in the assessment of phenolic content, antioxidant activity of White and red
wines spiked with green tea extract and grape seed extract found that the green
tea extract and grape seed extract increased antioxidant activity dose-
dependently and the CRTs varied considerably between the Korean and
Australian groups, with Koreans preferring wines spiked with green tea extract
and Australians showing a preference for wines spiked with grape seed extract,
according to "Total Phenolic Content, Antioxidant Activity and Cross-Cultural
Consumer Rejection Threshold in White and Red Wines Functionally Enhanced
with Catechin-Rich" by Yoo YJ, Saliba A, Prenzler PD, Ryan DM.(4)

5. Skin Photoprotection
In the study of polyphenols distributed in plant foods, such as, fruits,
vegetables, nuts, flowers, bark and seeds, etc., found that the selected
polyphenols include: green tea polyphenols, pomegranate fruit extract, grape
seed proanthocyanidins, resveratrol, silymarin, genistein and delphinidin. The
new information on the mechanisms of action of these polyphenols supports
their potential use in skin photoprotection and prevention of
photocarcinogenesis in humans, according to "Polyphenols: Skin
Photoprotection and Inhibition of Photocarcinogenesis" by Afaq F, Katiyar SK.
(5)

6. Renal Ischemia/Reperfusion Injuries
In the evaluation of grape seed proanthocyanidin extract (GSPE) protects
against renal I/R injury found that GSPE significantly reduced increases in
urea, creatinine and cystatin C; increased kidney superoxide dismutase activity
and glutathione peroxidase levels and reduced malondialdehyde levels. GSPE
reduced histological renal damage and nuclear factor-κB activity. These results
suggest that GSPE reduces renal dysfunction and injury caused by renal I/R,
according to "Grape Seed Proanthocyanidin Extract Reduces Renal
Ischemia/Reperfusion Injuries in Rats" by Wei R, Ding R, Wang Y, Tang L.(6)

7. Anticancers
a. In the reviews of Grapes and grape-based products as one such class of
dietary products and its cancer chemopreventive potential, indicated that
Overall, completed studies from various scientific groups conclude that both
grapes and grape-based products are excellent sources of various anticancer
agents and their regular consumption should thus be beneficial to the general
population, according to "Anticancer and cancerchemopreventive potential of
grape seed extract and other grape-based products" by Kaur M, Agarwal C,
Agarwal R.(7a)

b. In the study of the biological and chemopreventive activities of grapeseed
polyphenols and its inhibition of either initiation or promotion/progression
stages of carcinogenesis found that suggest that the chemopreventive activity of
polyphenols extracted from seedless grapecultivars was as effective as that of
the seeded variety and these may have beneficial effects in disease states,
especially cancer, according to "Antitumor-promoting effects of polyphenolic
extracts from seedless and seeded Indian grapes" by Ramchandani AG,
Karibasappa GS, Pakhale SS.(7b)

8. Colon Cancer
In the investigation of polyphenols of grape waste and its protection against
human diseases related to oxidative stress, such as colorectal cancer, found that
the grape extract has a significant antiproliferative effect in a tumor cell line.
These data indicate that grape extract is a promising product to be used as an
anti-free radical agent and could exert a chemopreventive action, according to
"Grape waste extract obtained by supercritical fluid extraction contains
bioactive antioxidant molecules and induces antiproliferative effects in human
colon adenocarcinoma cells" by Lazzè MC, Pizzala R, Gutiérrez Pecharromán
FJ, Gatòn Garnica P, Antolín Rodríguez JM, Fabris N, Bianchi L.(8)

9. Prostate cancer
In the analyzing the bioflavonoids from Grape seed extract (GSE) and theirs
effect on prostate cancer (PCA) found that that GSE possibly causes
mitochondrial damage leading to cytochrome c release in cytosol and activation
of caspases resulting in PARP cleavage and execution of apoptotic death of
human PCA DU145 cells. Furthermore, GSE-caused caspase 3-mediated
apoptosis also involves other pathway(s) including caspase 9 activation,
according to "Grape seed extract induces apoptotic death of human prostate
carcinoma DU145 cells via caspases activation accompanied by dissipation of
mitochondrial membrane potential and cytochrome c release" by Agarwal C,
Singh RP, Agarwal R.(9)

10. Atherosclerosis
in the association of consumption of red wine and other polyphenolic
compounds and prevention of cardiovascular diseases found that aortic
atherosclerosis evaluated as the cholesterol content in aortic tissue was
comparable in the control and GSE-dosed females, but it was significantly
reduced in the abdominal part of GSE-dosed male compared to the controls (P
< 0.05). In conclusion, feeding GSE extract to Watanabe heritable
hyperlipidemic (WHHL) rabbits had no significant effects in females but was
associated with transient less hypercholesterolemic response to semisynthetic
diet, according to "Effects of red grape skinand seed extract supplementation on
atherosclerosis in Watanabe heritable hyperlipidemic rabbits" by Frederiksen H,
Mortensen A, Schrøder M, Frandsen H, Bysted A, Knuthsen P, Rasmussen SE.
(10)

11. Arthritis (CIA)
in the examination of whether grape seed proanthocyanidin extract (GSPE)
effect on collagen-induced arthritis (CIA) in mice found that GSPE dose-
dependently suppressed osteoclastogenesis in vitro. GSPE significantly reduced
hydrogen peroxide production by anti-CD3-monoclonal-antibody-stimulated
CD4+ splenocytes. These results indicate that intraperitoneal injection of GSPE
attenuated CIA in mice. GSPE may be useful in the treatment of rheumatoid
arthritis, according to "Grapeseed proanthocyanidin extract (GSPE) attenuates
collagen-induced arthritis" by Cho ML, Heo YJ, Park MK, Oh HJ, Park JS,
Woo YJ, Ju JH, Park SH, Kim HY, Min JK.(11)

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Author Biography
Kyle J. Norton (Scholar, Master of Nutriyion, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published on line, including world wide health, ezine
articles, article base, healthblogs, selfgrowth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22162675
(2) http://www.ncbi.nlm.nih.gov/pubmed/18547852
(3) http://www.ncbi.nlm.nih.gov/pubmed/19051353
(4) http://www.ncbi.nlm.nih.gov/pubmed/22133028
(5) http://www.ncbi.nlm.nih.gov/pubmed/22070679
(6) http://www.ncbi.nlm.nih.gov/pubmed/22157385
(7a) http://www.ncbi.nlm.nih.gov/pubmed/19640973
(7b) http://www.ncbi.nlm.nih.gov/pubmed/19105538
(8) http://www.ncbi.nlm.nih.gov/pubmed/19627204
(9) http://www.ncbi.nlm.nih.gov/pubmed/12419835
(10) http://www.ncbi.nlm.nih.gov/pubmed/17441214
(11) http://www.ncbi.nlm.nih.gov/pubmed/19446580