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EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15

Ebola
Infectious
Disease Fact
Sheet
12/10/15
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blic/ebola_virus_on_a_green_monkey_cell.jpg?itok=MiH7btVq

“At this time the odds of getting Ebola in the U.S. are close to nil…the understanding of Ebola
and how its transmitted is REALLY low, we have to expect that one day there will be another By Jenny Butler
epidemic that has the capacity to enter our borders, and if we don’t know how it is transmitted,
we can’t protect ourselves properly.” For Clinical Microbiology
– Brandon Brown Section 2
Date published
12/8/15

carrying the virus, they spread the there are exposed mucous
What is Ebola virus to primates and jungle membranes or a weakness in the
Ebola is a viral infection also animals such as antelope and skin. It is important to note that
commonly known as Ebola porcupine.1,2,3,4 Coming in contact dirty needle exposure and other
hemorrhagic fever. More with body fluids of infected fomite transmission is another
specifically, Ebolavirus is an animals, their excrement, or way of contracting the virus.4
enveloped, single stranded RNA infected humans in the same
ways, will likely lead to an Although Ebola can be lethal, it is
virus, which among many other
Ebolavirus infection, especially if not nearly as contagious as other
transcriptional codons, carries the
codes for seven structural
proteins and two secreted soluble
proteins.1,3 These few sequences
not only help the virus to remain
hidden from the host cells, but
also carry the deadly protein
portion of the structure. 1

Virus Spread
The Ebolavirus lives in bats and
spread through droplet
transmission. Bats are considered
to be both a vector and reservoir
for the virus.2, 4 Although bats do
not appear to show any http://blog.thomsonreuters.com/index.php/how-contagious-is-ebola-graphic-of-the-day/
symptoms or problems related to
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 2

infectious diseases (see the chart include organ necrosis, most both young and old, though there
above). notably the liver, swelling of the is a significant advantage for
brain and kidneys as well as people who have adequate
Once the virus has penetrated the reduced clotting factor which is nutrition and access to clean food
host’s defenses, it attaches to the evidenced in bruising and and water supplies. 3,4 The
host cells via a glycoprotein and is poorest countries in
then Western Africa are some
phagocytized at greatest risk of death
leading to the and spread of the disease
subsequent because of way of life,
translation, living conditions,
transcription traditions, lack of
and spread of education and lack of
the virus.1,3 access to adequate
The medical care.
Ebolavirus’
main target In the map, the purple
seems to be dotted line represents the
monocyte, migratory patterns of the
macrophage fruit bats known to harbor
and dendritic http://www.who.int/csr/disease/ebola/global_ebolaoutbreakrisk_20140818-1.png?ua=1
the Ebolavirus. Notice
cells which are that the outbreaks (in
used in both innate and adaptive appearance of blood in the feces dark orange and peach) are found
immune responses. Neither and urine.1,2,3 in Africa, right near these
leukocytes nor NK cells are migratory patterns.
affected directly by the virus, but Mortality and Risk factors
do spontaneously undergo Unfortunately, Ebolavirus has a Local Epidemiology
apoptosis as part of the disease 40%-90% mortality rate In 2014, there were few cases of
process.3 depending on the strain. From 1, 3
Ebola in the United States and
onset of initial symptoms, the none in Utah. The cases in the
Signs and Symptoms patient has anywhere from 6-16 U.S. were from people who
If infected with the Ebolavirus, days before death. 1,2,3,4 It affects contracted the virus in Africa,
the host will have roughly 2-21 then flew here. 1
days before beginning
symptoms will appear. 1,2,3,4 There were two exceptions,
Symptoms include fever, nurses who unknowingly cared
weakness, vomiting, diarrhea, for an Ebola patient without
headache and sore throat. wearing appropriate protective
Because of the nonspecific clothing.
primary symptoms treatment Ebolavirus Numbers
can often be delayed.2 The
infected individual does not
and Trends
realize they have Ebola until When Ebolavirus was first
they have contaminated other identified during a 1976 outbreak,
well-meaning individuals. scientists documented the
incidence of the disease to be
After symptoms have appeared
https://thoughtfullyprepping.files.wordpress.com/2014/10/wh 612, localized to the South Sudan
they progress in severity to oebolasuit1.png and The Democratic Republic of
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 3

Congo regions.1 Since 1976 because of the mortality of the difficult at times which can lead
Ebolavirus has been shown to be disease, the necessity for quick to error and misdiagnosis.2
endemic in Africa. Every few and accurate testing is
years there is a brief and small paramount.2,3 This need for quick Diagnosis
epidemic of Ebola infections in testing is one of the biggest
When Ebola is suspected, the
localized regions, not reaching an challenges faced in Africa today.
time to make a
incidence
conclusive diagnosis
over 425
using proper laboratory
cases which
techniques can range
occurred
from 6 hours to 3 days,
during the
delaying interventions
year 2000 in
and increasing the
Uganda. In
patient’s risk of
the first 20
succumbing to the virus.
years from 2,4The need for quick
1976-1996 the
diagnostics is critical
prevalence of
because once infected,
Ebolavirus
the virus multiplies very
was 924, and
rapidly and in many
more recently http://www.broadsheet.ie/2014/10/01/a-limerick-a-day-485/ cases, the body simply
from 1997-2014 the
Accurate, timely tests which are does not have enough time to
prevalence was 2250, showing
sensitive and require specialized develop the antibodies to fight
about a 41% increase in
equipment are simply not the infection before death
prevalence over the initial 20 year
available in the field abs.4 Lab occurs.4
recorded cases.1
tests like Polymerase Chain Disease Treatment
Recent numbers of cases from reaction test, which use blood
the 2014 Ebola outbreak estimate samples to detect viral nucleic Viruses in general are notoriously
the incidence of infected acids, and the Antigen ELISA difficult to treat. No antiviral
individuals at around 1009 yet the (Enzyme-linked immunosorbent medications have yet been
most glaring difference between assay) test, which also uses blood developed for the specific use on
previous outbreaks and the 2014 but detects a viral antigen, are Ebola patients. Some
outbreak is that (in addition to accurate and quick. However anticoagulant administration has
the number of infected both require specialized been effective in laboratory
individuals) the outbreak was not equipment and conditions. The animals, which slows the progress
isolated to just one or two specific standard ELISA test, which uses of the disease, but does not treat
locations, it affected other blood samples to detect virus it directly. A combination of many
regions throughout Western antibodies, is accurate, but drugs may be necessary to fully
Africa including Guinea, Sierra slower.2 Other lab tests like treat the virus. 2, 3
Leone, Liberia, Nigeria and Immuno-blot (western blot) and Development of a vaccine for
others.1, 2 Indirect immunofluorescence Ebolavirus has come a long way,
assay (IFA) which both use blood and has shown progress in
Diagnostic procedures samples to detect the presence of laboratory animals, however,
Initial diagnosis of Ebola is virus-specific antibodies, are there is not an approved vaccine
difficult. The beginning quick and require little against Ebola.2
prodromal symptoms are not equipment, but results are often
definitive enough to warrant up to interpretation which can be
further testing.2,4 However,
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 4

Since there is not yet a cure or

Disease Prevention
vaccine for Ebolavirus, much of
the ability to survive the disease is
dependent on access to adequate
medical care, including
rehydration and the use of IV
fluids, comfort care. 4
The greatest chance at survival is
not contracting the virus.
Educating the populations most
at risk about how the virus is
transmitted specifically the best
ways of cleaning and using bush
meat, clean drinking water,
proper hand washing and
http://news.sciencemag.org/africa/2014/08/who-reports-ebola-deaths-drc
sanitizing procedures. Also
addressing the cultural burial obvious reasons, this hasn’t been from and diminish virus
practices of certain African tribes tested in humans.2 transmission. Until a vaccine or
will go a long way in stopping the cure is found, the solution to
spread of the Ebolavirus. 4 If you are one of the lucky ones, ongoing epidemics and the
and survive, problems such as possibility of a pandemic is
Survival deafness, joint pain, prevention, education and
Chance of recurrence of the inflammation of the testicles and disinfection.
disease in a person who has pericarditis may linger.2, 4 Also,
already been infected is not well just because your major
known, but studies on animals symptoms have disappeared does
have shown that system not mean the virus is completely
immunity can be developed.2 gone. The specific Ebolavirus RNA
sequence has been isolated in 1. Chowell, Nishiura. 2014. Transmission
Surviving the disease has much to dymanmics and control of Ebola virus
do with the incubation period of survivors up to 101 days after Disease (EVD): a review. BMC Medicine
the virus in an individual. 4 development of initial 12:196

Survivor’s blood work symptoms.4 2. Clercq. 2014. Ebola virus (EBOV) infection:
Therapeutic strategies. Biochemical
consistently shows elevated IgM Pharmacology. V 93, issue 1, p 1-10.
and IgG levels, where deceased
Implications for 3. Falzarano, Feldmann, Groseth, Hoenen.
2006. Ebola virus: unravelling pathogenesis
individuals show little IgM and no healthcare to comba a deadly disease. Trends in
beneficial IgG levels. Also, those In order to treat and prevent Molecular Medicine, V 12, Issue 5, p 206-215.
Ebola, in addition to faster 4. Jayant, Kaushik, Nair, Tiwari. 2015.
who succumbed to the virus show
Towards detection and diagnosis of Ebola
significantly lower levels of T- diagnostics and access to medical virus disease at point of care. Biosensors and
cells.3 care, healthcare workers must Bioelectronics. V75, 15 Jan 2016, p 254-272.
use proper antisepsis techniques
It is not yet clear if the immunity such as running water and soap as
is long-term or temporary and if well as an alcohol based solution.
the antibodies produced protect Also imperative is the use of PPE
against all strains of the virus. For (personal protective equipment)
which will provide protection
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 5

Using styles helps save you time and keep


your document consistent. To modify a style,

Using Styles
on the Home tab, in the Styles group, right-
click the name of the style you want to edit
and then click Modify. All content where the
by Name Style style is applied will update automatically.

Another way to modify a style is to simply


customize an instance of the style where it’s
The body text throughout the articles in this applied in the document. Then, on the Home
template uses the Normal paragraph style. tab, in the Styles group, right-click the style
Following are some other styles applied name and then click Update [style] to Match
throughout the template: Selection.

 Large article titles, such as on the first HEADING 4 STYLE


page, use Heading 1 style.
 Orange headings in the sidebars and Use the small tables provided in some of the
within articles use Sidebar Heading articles to call out quick reference
style. information related to the article, such as
contact information or event dates.
 Orange section titles in articles use the
Heading 2 style. HEADING 5
Contact Info
 Small article titles use Heading 3 style.
 This style is List Bullet 2.
This style is List Continue.
 Text in sidebars uses the Sidebar Text
style.
 White headings on orange text in tables
uses the Heading 4 style.
 The heading inside contact information
tables uses Heading 5 style.
 Contact Info is the name of the gray
text style inside the small contact
tables.
Access all styles used in this template on the
Home tab, in the Styles group.
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15
This picture caption uses the Caption 2
paragraph style and is inside a text box To setup a document for multiple column
so that you can move it easily as text, on the Page Layout tab, in the Page
needed to accompany a photo. Setup group, click Columns and then click
the number of columns you need. You can
also click More Columns to specify column
widths, the space between columns, or to
automatically add a vertical line between
columns.

To change the number of columns for just


part of the document (or if you want text to
wrap to just the top part of the page and a
new article to start below – as shown on this
page), insert a section break before the
position where you want to start the new
column layout. To do this, on the Page
Layout tab, in the Page Setup group, click
Breaks and then click the type of section
break you need.

Select a section break


When changing many types of page layout
formatting for just part of the document—
such as paper size, margins, or orientation,
the best section break type to use is a Next
Page section break because it automatically
starts the new section on a new page.
However, when changing the number of
columns as you might in this newsletter, you
may prefer to select a Continuous break. The
continuous section break (used a few times
throughout this template) starts a new
section immediately after the preceding one.
So, for example, you can have a three-
column article followed by a four-column
article, on the same page.

Working with Columns


by [Article Author]
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 7

HEADING 4 This placeholder article provides the

42%
following tips: Caption 2 style is used to add
picture captions. Captions are in
 Creating “thermometer charts”
text boxes for easy using
placement
relative
tables, as shown attoleft.
images.
Cras ut blandit diam. Suspendis quis urna semper
aliquam.  Setting up multipage articles.
 Wrapping text around images
FOR MORE INFORMATION  Adding article titles and bylines

Abico eum, ille et, conventio obruo duis Creating the sidebar
ullamcorper ut, neo demoveo. Vel reprobo:
thermometer charts
HEADING 5 When you work in Word 2010 (or PowerPoint
Contact Info 2010), you have the full power of Excel 2010

Formatting Tips
by [Article Author]

charts (provided that Excel is installed on


your computer). Insert a chart in Word from
the Insert tab, in the Illustrations group.
Charts are easy to create and use and
automatically coordinate with your active
document theme.

However, notice in the sidebar at left that the


“thermometer charts” were created using
single-row Word tables. This is because they
automatically fit the tight space without
Sidebar Setup having to remove any chart elements. And
The sidebars in this template use simple, single-row you might be surprised to learn that it’s easy
tables for the gray-shaded headings and thermometer to make them essentially mathematically
charts shown below for easy alignment. accurate.

To use a table as a thermometer chart, do


the following:

1. On the Insert tab, in the


Tables group, click Table
and then drag across the
grid to select the first
two cells in the
first row. Click to
insert a two-cell,
one-row table.
2. Click in the table and
Add Sidebar Content then, on the Table
Adding content into a column to create a sidebar is no
different from adding text. As noted earlier in this Tools Layout
template, apply the styles provided for headings, tab, in the
sidebar text, and even pictures to align them quickly and Table group,
easily. click Properties.
3. On the Columns tab of
FAST FACTS the Table Properties dialog box, change
the Measure In setting to Percentage.
You can then set the percentage to up

68%
to one decimal point in accuracy.

Setting up multipage articles


Word is designed to allow text to
Learn about these “thermometer charts” in the article at automatically flow from one page to the
right.
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 8

next. So, when you want an article to 1. On the Picture Tools Format tab, in the because text can wrap around a text box just
continue on the next page, just keep typing. Arrange group, click Wrap Text and then like it can around a picture. Similarly, the
select either Square, Tight, or Top and orange divider bars that you see on pages
In the case of this placeholder article, it is Bottom—depending on how you want containing more than one article are shapes
separated into two placeholder content the text to wrap. set to wrap text. So, these text boxes and
controls (one on this page and another that shapes can easily span multiple columns
starts at the top of the following page) just so You might be happy with the default without having to insert a section break or
that you can still see the layout of the behavior as soon as you do this. change the number of columns for just that
following page while you begin adding your Otherwise, continue to step two for portion of the page.
own text on this page. As mentioned on the customization options.
first page of this template, remember that it When you select a text box or a shape, on the
2. To set a specific position or control
might look like the layout is skewed when Drawing Tools Format tab, in the Arrange
behavior (such as whether or not the
you replace a long piece of placeholder text group, you have the same settings for text
image moves with text), on the Picture
by starting to type your own, but it is not. As wrapping and positioning that are described
Tools Format tab, in the Arrange
you add your content, the layout that follows above for wrapping text around pictures.
group, click Position and then click
will move down automatically and back into
More Layout Options. Note that, because text is set to wrap around
position.
the orange divider bars, your article might
 On the Text Wrapping tab of the
To remove the second placeholder control appear to slip below or above a bar,
Layout dialog box, you can set a specific
that starts immediately following this one, depending upon length. To adjust the
distance from the image for text to wrap
just select it and then press any key. You can position of a divider bar shape to
and control whether text can wrap on
then continue typing from this page and your accommodate the length of your articles,
both sides, one side only, or just above
text will automatically flow onto the next. just select the shape and then use the up and
and below the image.
down arrow keys on your keyboard to nudge
Wrap text around images  On the Position tab of that dialog box, it to the proper position.
you can set a specific position for the

The photos in this article that are angled with image on the page
white borders are “floating” images. That is, and select or clear
they are setup for text to wrap around the option to
them—which is why they can span multiple allow the picture
columns in a three-column section. to move with text.
Additionally, as mentioned earlier, the photo
of the young woman in the body of this Adding article
article is set to wrap text so that text will flow titles, bylines,
around the image as you add your own text. and dividers
The article titles and
To select text wrap settings, start by
bylines for this
selecting the image and then do the
newsletter are created
following:
in text boxes. This is
Notice the image of the young woman that’s Remove Background
within a text column on the preceding page. tool that you can use to
The background has been removed from that remove backgrounds
image to allow text to wrap directly around from your own images,
the subject. similar to the sample
image on the
preceding page. and then drag your mouse pointer in a line
Office 2010 introduced several new and
across the portion of the image you want to
improved picture formatting tools in Word,
To do this in Word, first insert your image add or remove. When you are finished
PowerPoint, and Excel. Among those is the
into the document (on the Insert tab, click making adjustments, click Keep Changes.
Picture), and then select it. Then, on the
Picture Tools Format tab, in the Adjust FOR MORE INFORMATION
group, click Remove Background.
Abico eum, ille et, conventio obruo duis
The Remove Background feature ullamcorper ut, neo demoveo. Vel reprobo:
automatically displays what it believes to be HEADING 5
the central subject of the image. However, Contact Info
it’s easy to adjust this if the immediate result
is not what you need.

On the Background Removal tab, click Mark


Areas to Keep or Mark Areas to Remove
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 9

Remove Image
Backgrounds
by [Article Author]
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 10

AROUND TOWN

Title Lorem Ipsum Dolor


by [Article Author]

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feugiat vitae magna. Nullam pellentesque, Praesent ultrices odio in elit fringilla id
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interdum. Nullam at metus erat, in convallis Nulla semper orci id leo adipiscing at pulvinar ante
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adipiscing elit. Nullam sed luctus tellus.
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massa. Donec nunc velit, pretium eu Phasellus sagittis tempus massa, a tempor
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commodo. Aliquam tempus aliquam mauris convallis et. Morbi rutrum mollis facilisis.
vel dapibus. Nullam at metus erat, in Aenean faucibus sapien erat, eu pharetra
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EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 11

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Ebola
Infectious
Disease
Fact Sheet
12/10/15

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[City, ST ZIP Code]
EBOLA INFECTIOUS DISEASE FACT SHEET 12/10/15 | 12

[Addressee]
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