You are on page 1of 155

A P I PUBL>x4634 95 E 3 0 7 3 2 2 9 0 0 5 4 9 9 5 4 7 9 0

Amencan
Petroleum
Institute

~~

Index and Abstracts


of API Health-Related
Research
13th Edition
1959-1994
Health and Environmental Sciences Department
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

PublicationNumber 4634
September 1995

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLX4634 95 0732290 0 5 4 9 9 5 5 627

Index and Abstracts


of API Health-Related Research

13th Edition
1959-1994

Health and Environmental Affairs Department

API PUBLICATION NUMBER 4634

SEPTEMBER 1995

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

American
Petroleum
I Institute

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API PUBL*4634 95 m 0732290 0549956 5 6 3 m

FOREWORD

API PUBLICATIONS NECESSARILY ADDRESS PROBLEMS OF A GENERAL


NATURE. WITH RESPECT TO PARTICULAR CIRCUMSTANCES, LOCAL, STATE,
AND FEDERAL LAWS AND REGULATIONS SHOULD BE REVIEWED.

API IS NOT UNDERTAKING TO MEET THE DUTIES OF EMPLOYERS, MANUFAC-


TURERS, OR SUPPLIERS TO WARN AND PROPERLY TRAIN AND EQUIP THEIR
EMPLOYEES, AND OTHERS EXPOSED, CONCERNING HEALTH AND SAFETY
RISKS AND PRECAUTIONS, NOR UNDERTAKING THEIR OBLIGATIONS UNDER
LOCAL, STATE, OR FEDERAL LAWS.

NOTHING CONTAINED IN ANY API PUBLICATION IS TO BE CONSTRUED AS


GRANTING ANY RIGHT, BY IMPLICATION OR OTHERWISE, FOR THE MANU-
FACTURE, SALE, OR USE OF ANY METHOD, APPARATUS, OR PRODUCT COV-
ERED BY LETTERS PATENT. NEITHER SHOULD ANYTHING CONTAINED IN
THE PUBLICATION BE CONSTRUED AS INSURING ANYONE AGAINST LIABIL-
ITY FOR INFRINGEMENT OF LETTERS PATE".
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Copyright Q 1995 American Petroleum Institute

ii

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
~

A P I P U B L + 4 6 3 4 95 M 0 7 3 2 2 9 0 0549957 4 T T

ACKNOWLEDGMENTS

THE FOLLOWING PEOPLE ARE RECOGNIZED FOR THEIR CONTRIBUTIONS OF


TIME AND EXPERTISE IN THE REVISION AND IN THE PREPARATION OF THIS
INDEX AND ABSTRACTS, 13th EDITION:

API STAFF
Karen Vaucrosson ,Health and Environmental Sciences Department - Indexing

Edna Paulson, API Librarian - Indexing

Christine Sexsmith*, Health and Environmental Sciences Department - Indexing

Steven Riley, Information Systems - Database Management


--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

*No longer employed with this organization.

iii

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
The Health and Environmental Sciences Department (HESD) of the American Petroleum Institute (API) sponsors
petroleum health-related research in the areas of industrial hygiene and exposure assessment, toxicology,
environmental biology, product safety, and community and occupational health. The reports and 'publications
indexed and abstracted here are a compilation of research investigationdreviews conducted for API from 1959
through the end of 1994. For additional information including articles published in the peer-reviewed literature,
on-line searching is recommended.

-
The Subject Index
The subject index of the 13th edition of Index and Abstracts of API Health-Related Research has been
simplified to include a comprehensive list of key terms alphabetically arranged by "petroleum product of
interest," "test conducted" or by "authors/organizations."The main headings in the subject index appear in bold.
Subheadings appear in italics. Each study in the subject index is identified by its full title followed by a unique
number (xx-xxxxx) in parentheses, which also identifies the study's abstract. Numbers are arranged numerically
in the Abstracts Section.

I -
The Abstracts
Prepared by the staff of API's Central Abstracting & Information Service, abstracts include a 'Isource" field
providing the user with one of four descriptors on report availability. These include:

API HESD Information Specialist;


Not Available from API;
API Library;
API Publications.

--
API HESD Information Suecialist

Copies of research or departmental reports indicated as API Med Res. Pub1 or API Health Environ. Sci.
Dep. Rep. can be obtained by contacting the information specialist at (202)-682-83 19 or fax (202)-682-
8270).

Not Available from API


To access a report or document not published by API, users must contact the publisher directly
or check at a university library. A full citation including the name of the publisher and year of
publication is provided.

-
API Library

API publications that are no longer in print are archived in the API Library and can be ordered by
calling (202)-682-8042 or fax (202)-682-8232. Library staff provide price information.

-
API Publications
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Please call the API Publications Order Desk at (202)-682-8375 or fax (202)-962-4776 to order
publications. API members get 20% discount. Discounts for bulk orders are available.

Users of this edition of Index and Abstracts should note that it does not include API-sponsored
environmental research such as facility emissions, air quality modeling, soil and groundwater
remediation etc. Descriptions of these studies can be found in the current API publications, programs
and services catalog. To obtain a copy, call (202) 682-8375.

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 75 O732290 0547957 2 7 2

TABLE OF CONTENTS

Section .............................................................. Page

AuthorIndex ............................................................. 1

OrganizationIndex ......................................................... 5

Subject Index ........................................................... 11

Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61

NOTE

The following API health publication does not appear in the Index and Abstracts Sections because it is
updated annually. Please check with the API Publications Order Desk (202)-682-8375 for the most
current publication number and price.

4130283
Results of toxicological studies [of petroleum and related materials] conducted for the American Petroleum Institute. This volume is a compilation
of the API toxicological studies performed on petroleum-based materials, including gasoIine and naphthas. middle distillates,lubncating oil base stocks, heavy
fuel oils, hydrocarbon and petroleum solvents, and miscellaneous materials btroleum cokes, crude oils and their fractions, shale oils. shale solids, shale
oil-denved fuels. SRC distillate, MTBE, and TAME). The entries for h e studies are tabulated by the category of test materia within each entry, information
is included about the test performed, the animal species tested, and test results. An abstract number for the study is also given, corresponding to the number
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

appearing in the Inder and Abstrucu of API Health-Reluied Reseurch. the APILIT citation base, and API Literature Abstracts. Each year, updated entries
(pages) will be made available to purchasers of this publication.
API Publicarion #45591 (January 1994) (187 p.).
Source: API Publications Order Desk (Order No. 145591)

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L m 4 6 3 4 95 0732270 0 5 4 î î b 0 T î 4 =

AUTHOR INDEX

Ackerman LI . . . . . . . . . . . . . . . . 30-31535 Birkhead NC . . . . . . . . . . . . . . . . 27.30966 Coate WB . . . . . . . . . . . . . . . . . . 30-32012


Albert RE . . . . . . . . . . . . . . . . . . 33-31094 Blank IH . . . . . . . . . . . . . . . . . . . 33-31225 Cockrell BY . . . . . . . . . . .
Albrecht RM . . . . . . . . . . . . . . . . 2660053 Bogo V .................... 30-31533 Cockrell BY . . . . . . . . . . .
Alden CL . . . . . . . . . . . . . . . . . . 32-30409 Bowers JC . . . . . . . . . . . . . . . . . . 36-31431 C o c k d l BY . . . . . . . . . . . . . . . . 33-3 1098
Alderson MR . . . . . . . . . . . . . . . .31-30449 Brannon EL . . . . . . . . . . . . . . . . . 34-32982 C o c k d l BY . . . . . . . . . . . . . . . . 33-31223
Ament ML . . . . . . . . . . . . . . . . . . 27-32177 Brannon EL . . . . . . . . . . . . . . . . .40.33133 Cockfell BY . . . . . . . . . . . . . . . . 34-30857
Anderson GE . . . . . . . . . . . . . . . . 34-32923 Brennan C . . . . . . . . . . . . . . . . . .40.32425 Cockrell BY . . . . . . . . . . . . . . . .37-3 1148
Anderson JW . . . . . . . . . . . . . . ..26 -6ûûO2 Brennan C . . . . . . . . . . . . . . . . ..40.32426 Cole P ..................... 31-31480
Anderson JW . . . . . . . . . . . . . . . . 26.60030 Brewer T . . . . . . . . . . . . . . . . . . . 37-31958 Coleman JH . . . . . . . . . . . . . . . . . 33-32009
Anderson JW . . Bromberg I . . . . . . . . . . . . . . . . 33-31096 Colucci AV . . . . . . . .
Anderson JW . . Bromberg PA . . . . . . . . . . . . . . . . 26-60022 Colucci AV . . . . . . . .
Anderson JW . . . . . . . . . . . . . . . . 33-32871 Bromberg PA . . . . . . . . . . . . . . . . 26-60023 Colucci AV . . . . . . . . . . .
AM* C . . . . . . . . . . . . . . . . . . . 32-31472 Brooker AJ . . . . . . . . . . . . . . . . .40-32425 Combs DW . . . . . . . .
AMY C . . . . . . . . . . . . . . . . . . . 32-32405 Brooker AJ . . . . . . . . . . . . . . . . .40.32426 Conaway CC . . . . . . . . . . . . . . . .30-3 1997

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
AMY C . . . . . . . . . . . . . . . . . . . 34-30857 Brown NA . . . . . . . . . . . . . . . . . . 34.32714 . . . . . . . . . . . .32-31299
AITIMAD . . . . . . . . . . . . . . . . . . 36-31431 Brubaker PE ................ 32-32502 . . . . . . . . . . . . 33-31095
Austin BS . . . . . . . . . . . . . . . . . . 34-32923 Bruner RH . . . . . . . . . . . . . . . . . . 30-31534 Conway J . . . . . . . . . . . . . . . . . .39-31095
Austin H . . . . . . . . . . . . . . . . . . . 31-31480 Bruner RH . . . . . . . . . . . . . . . . . .30-31537 Coombs DW . . . . . . . . . . . . . . . .40-32425
Avery DL . . . . . . . . . . . . . . . . . . 30-32063 Bruner RH . . . . . . . . . . . . . . . . . . 32-30416 Coomes RM . . . . . . . . . . . . . . . .30-32001
Avo1 EL . . . . . . . . . . . . . . . . . . . 26-60029 Brusick DJ . . . . . . . . . . . . . . . . . .27-32179 Cooper GP ................. . 26-60025
Bachand RT . . . . . . . . . . . . . . . . . 26-60001 Buffier PA . . . . . . . . . . . . . . . . . .32-30418 Cooper GP . . . . . . . . . . . . . . . . . . 30-32081
Bailey RM . . . . . . . . . . . . . . . . . .26-60029 Buikema AL . . . . . . . . . . . . . . . . 2 6.31781 Copper WC . . . . . . . . . . .
Baldwin JK ................. 31-32162 Buikema AL . . . . . . . . . . . . . . . . 27.32296 Coitina TA . . . . . . .
Banejee CM . . . . . . . . . . . . . . . . 26-60054 Burden LW . . . . . . . . . . . . . . . . . 26.60063 cowan MJ . . . . . . . . . . . . . 30-31534
Banejee CM . . . . . . . . . . . . . . . . 27-30966 Burden LW . . . . . . . . . . . . . . . . . 28-70300 COXBA . . . . . . . . . . . . . . . . . . .. 26-60030
Baretta ED . . . . . . . . . . . . . . . . . .26 -60001 Burg W .................... 30-32081 Cragg ST . . . . . . . . . . . . . . . . . . . 30-31982
Baretta ED . . . . . . . . . . . . . . . . . . 26-60048 B U ~SL S . . . . . . . . . . . . . . . . . . . 29.90299 Cragg ST . . . . . . . . . . . . . . . . . . . 30-31997
Barkley W . . . . . . . . . . . . . . . . . . 30-31999 Burns JM . . . . . . . . . . . . . . . . . . 34-32600 Cragg ST . . . . . . . . . . . . . . . . . . .30-32000
Battigelli MC . . . . . . . . . . . . . . . .26-60024 Busey W M . . . . . . . . . . . . . . . . .27 .3û704 Cragg ST . . . . . . . . . . . . . . . . . . . 30-32063
Battigelli MC . . . . . . . . . . . . . . . . 26-60058 Busey W M . . . . . . . . . . . . . . . . . 32-30407 Cragg ST . . . . . . . . . . . . . . . . . . .32-31299
Battigeiìi MC . . . . . . . . . . . . . . . . 26-60071 Butler RG . . . . . . . . . . . . . . . . .. 4 0.3û740 Craig IC . . . . . . . . . . . . . . . . . . . 33-32721
Battigelli MC ............... . 26-60095 Cairns J .................... 26-3 1781 Craig JC . . . . . . . . . . . . . . . . . . .33-32910
Baturay NZ . . . . . . . . . . . . . . . . . 3 1-30263 Calisti U . . . . . . . . . . . . . . . . . . . 27-31528 Cranmer JM . . . . . . . . . . . . . . . . . 30-32063
Baylor CN . . . . . . . . . . . . . . . . . . 26-60093 Capei JE . . . . . . . . . . . . . . . . . . . 40-32761 Cranmer JM . . . . . . . . . . . . . . . . .30-32836
B a t t y P . . . . . . . . . . . . . . . . . . . 36-33132 Carpenter CP . . . . . . . . . . . . . . . . 26-fNO82 Curren RD . . . . . . . . . . . . . . . . . . 35-32431
Beck LS . . . . . . . . . . Carpenter CP . . . . . . . . . . . . . . . .26.60083 Dahl AR . . . . . . . . . . . . . . . . . . . 34-33036
Beck LS . . . . . . . . . . . . . . . . . . . 27-32130 Carpenter CP . . . . . . . . . . . . . . . . 26-60084 Daisey JM . . . . . . . . . . . . . . . . . . 28-31614
Beck LS . . . . . . . . . . . . . . . . . . .27-32131 Carpenter CP . . . . . . . . . . . . . . . . 2660085 Dalbey W . . . . . . . . . . . . . 30-31531
Beck LS . . . . . . . . . . . . . . . . . . .30-31530 Carpenter CP . . . . . . . . . . . . . . .. 2 6.60086 Daly IW . . . . . . . . . . . . . . . . . . . 37-31151
Beck LS . . . . . . . . . . . . . . . . . . . 30-32011 Carpenter CP . . . . . . . . . . . . . . .. 2 6.60087 Damon EG . . . . . . . . . . . . . . . . . 34-33036
Beckman EL . . . . . . . . . . . . . . . . 2 6 -60031 Carpenter CP . . . . . . . . . . . . . . . . 2660088 Dauvin EM . . . . . . . . . . . . . . . . . 37-31958
Beckman EL ................ 26-60032 Carpenter CP . . . . . . . . . . . . . . . . 2 6-60089 Davies DM . . . . . . . . . . . . . . . . . 3 1-32980
Beliles RP . . . . . . . . . . . . . . . . . . 27-32174 Carpenter CP ............... . 2 6-60090 DeBias DA . . . . . . . . . . . .
Beliles RP . . . . . . . . . . . . . . . . . . 27-32175 Carpenter CP ............... . 2 6-60091 DeBias DA . . . . . . . . . . . .
Belies RP . . . . . . . . . . . . . . . . . . 27-32176 Carpenter CP ................ 26-60123 Decker CE . . . . . . . . . . . . . . . . . . 26-60051
Beliles RP .................. 30-32003 Carpenter CP ............... . 2 6 -60124 Delauze HG . . . . . . . . . . . . . . . . . 26.60035
Beliles RP . . . . . . . . . . . . . . . . . . 2 7 -32177 Carpenter CP ............... . 2640125 Delbrueck WR . . . . . .
Beii KA .................. . 2 6-60029 Carpenter CP . . . . . . . . . . . . . . . . 27.31349 Deleon IR . . . . . . . . .
Bell KA ................... 27-30839 Carpenter CP . . . . . . . . . . . . . . . . 2 7 .3 i350 Depeyster A . . . . . . . . . . . . . . . . . 303 1095
Bell KA . . . . . . . . . . . . . . . . . . . 27-30842 Carpenter CP . . . . . . . . . . . . . . . . 2 7 .31351 Dickinson J . . . . . . . . . . . . . . . . . 30-32007
Benenson AS . . . . . . . . . . . . . . . .39-31095 Carpenter CP ................ 27-3 1352 Dickinson J . . . . . . . .
Bennett PB . . . . . . . . . . . . . . . . . 26-60033 Cam RS . . . . . . . . . . . . . . . . . . .. 33.3287 1 Dickinson J . . . . . . . .
Bernstein D . . . . . . . . . . . . . . . . . 2 6-60094 Cavender FL . . . . . . . . . . . . . . . . 30-32005 Digsby GM . . . . . . . .
Bernstein DM . . . . . . . . . . . . . . . 2 7 -30840 Chan L . . . . . . . . . . . . . . . . . . . . 39.31095 DiSbeMen DB . . . . . . . . . . . . . . . 30-31535
Beyrouty P ................. 37-3 1153 Chin BH . . . . . . . . . . . . . . . . . . .27 .31528 Dodd HC . . . . . . . . . .
Biles RW . . . . . . . . . . . . . . . . . . 35-30687 Chnstensen CC . . . . . . . . . . . . . . 41-30101 Domask WG . . . . . . . . . . . . . . . .32-01363
Bingham E ................ .27 -30915 Clark CR . . . . . . . . . . . . . . . . . . . 30-31998 Donohm KK . . . . . . . . . . . . . . . . 26-60048
Birkhead NC ............... . 26-60054 Coate WB .................. 30-31535 Dreyer NA . . . . . . . . . . . . . . . . . . 37-31336

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 0 7 3 2 2 9 0 0 5 4 9 7 6 3 720

Durloo RS . . . . . . . . . . . . . . . . . . 30-32012 Guerin M . . . . . . . . . . . . . . . . . . 30-31531 Honaker RW . . . . . . . . . 26-60040


Easley JR . . . . . . . . . . . . . . . . . . 30-3 1536 Gunnison AF . . . . . . . . . . . . . . . . 26-60023 Hoover AW . . . . . . . . . . . . . . . . .26-60053
Edel PO . . . . . . . . . . . . . . . . . . . 26-60041 Haas JF .................... 27-32467 Hoover BK . . . . . . . . . . . . . . . . . 30-32064
Edwards DA . . . . . . . . . . . . . . . . 36-33132 Hackney JD . . . . . . . . . . . . . . . . .26-60029 Hoover BK ...
Eisenbud M . . . . . . . . . . . . . . . . . 26-60094 Hackney JD . . . . . . . . . . . . . . . . .26-60045 Hosko M l . . . . . . . . . . .
Elsion RA . . . . . . . . . . . . . . . . . . 33-30665 Hackney JD . . . . . . . . . . . . . . . . . 27-30839 Howd RA . . . . . . . . .
Erlichman MN . . . . . . . . . . . . . . . 33-31096 Hackney JD . . . . . . . . . . . . . . . . . 27-30841 Howd RA . . . . . . . . .
Faeder E3 . . . . . . . . . . . . . . . . . . 32-32502 Hackney JD . . . . . . . . . . . . . . . . . 27-30842 Hughes M . . . . . . . . .
Fairchild El . . . . . . . . . . . . . . . . . 26-60037 Hackney JD . . . . . . . . . . . . . . . . . 28-33073 Hulse M . . . . . . . . . . . . . . . . . . . 39-31651
Feldman R . . . . . . . . . . . . . . . . . . 26-60080 Hake CH . . . . . . . . . . . . . . . . . . . 24.30057 IrWieD . . . . . 31-32980
Feldman R . . . . . . . . . . . . . . . . . . 26.60122 Hake CL . . . . . . . . . . . . . . . . . . .26-60043 Ivett JL .................... 35-30933
Feüingham GW . . . . . . . . . . . . . . 33.30665 Halder CA . . . . . . . . . . . . . . . . . .32-30414 lvett JL .................... 35-30934
Fems BG . . . . . . . . . . . . . . . . . . 26-60116 Halder CA . . . . . . . . . . . . . . . . . . 33-31098 Jacobs MM . . . . . . . . . . . . . . . . . 30-31646
Finch GL .................. . 3 0.31992 Halder CA . . . . . . . . . . . . . . . . . .33-31223 Jacobson-Kram D . . . . . . . . . . . . . 37-31149
Fisher GL . . . . . . . . . . . . . . . . . .30-3 1992 Halder CA . . . . . . . . . . . . . . . . . . 34-30857 Jacobson-Kram D . . . . . .
Fûlinsbee LI . . . . . . . . . . . . . . . . 32-31232 Haider CA ................. . 3 4.32600 Jagannath DR . . . . . . . . .
Forster HV . . . . . . . . . . . . . . . . . 26.60043 Haley TJ . . . . . . . . . . . . . . . . . . . 26.60061 Jeffcoat AR . . . . . . . . . .
FW TJ . . . . . . . . . . . . . . . . . . . 30-31994 Hailiwell WH . . . . . . . . . . . . . . . . 3032845 Jenkins R . . . . . . . . . . . . . . . . . . 30-31531
FW TJ . . . . . . . . . . . . . . . . . . . 32-32749 Hailak M . . . . . . . . . . . . . . . . . . 41-31765 Jessup JC . . . . . . . . . . . . . . . . . .26-60096
FW TJ . . . . . . . . . . . . . . . . . . . 33-31034 Hammond SK . . . . . . . . . . . . . . . 41-3 1765 John DM . . . . . . . . . . . . . . . . . . .40-32425
FIXE TJ . . . . . . . . . . . . . . . . . . .37-31827 Hansen KL . . . . . . . . . . . . . . . . . 30-31530 John DM . . . . . . . . . . . . . . . . . . . 4 0.32426
Fraser DA . . . . . . . . . . . . . . . .. 2 6.60071 Harbell JW . . . . . . . . . . . . . . . . . 36-31909 Johnson TR . . . . . . . . . . . . . . . . .40.32761
Freedman ML . . . . . . . . . . . . . . .. 26.60078 Harbeii JW . . . . . . . . . . . . . . . . . 36-31910 Jungen H . . . . . . . . . . . . . . . . . . .33-31598
Friedman MHF . . . . . . . . . . . . . . . 27-30966 Harbell JW . . . . . . . . . . . . . . . . . 36-31911 KainzlU . . . . . . . . . . . . . . . . . . . 30-32078
Frome EL . . . . . . . . . . . . . . . . . . 30-31983 Harbell JW . . . . . . . . . . . . . . . . . 36-31912 Kaibfleisch JH . .
Gamble JF . . . . . . . . . . . . . . . . . .26.60024 Harbell J W . . . . . . . . . . . . . . . . . 36-31913 Kaibfleisch JH . . . . . . . . . . . . . . . 26.60048
Garcia H . . . . . . . . . . . . . . . . . . . 26-60122 Harbeii J W . . . . . . . . . . . . . . . . . 37-30618
Garcia U . . . . . . . . . . . . . . . . . .27-33273 Harbell JW . . . . . . . . . . . . . . . . . 37-30619
Garfinkel S . . . . . . . . . . . . . . . . . 30.31531 Harbeii JW . . . . . . . . . . . . . . . . . 37-30620 K a l ~ n ySP . . . . . . . . . . . . . . . . . 34-32982
Gaworski CL . . . . . . . . . . . . . . . . 30-31534 Harbell J W . . . . . . . . . . . . . . . . . 37-31487 Kane ML . . . . . . . . . . . . . . . . . . . 31-02438
Geary DL . . . . . . . . . . . . . . . . ..26.60082 Harley NH .................. 30-3 1647 Kanewa RL . . . . . . . . . . . . . . . . . 32-30409
Geary DL . . . . . . . . . . . . . . . . ..26 -60083 Hastings L . . . . . . . . . . . . . . . . . .26 -60025 Kaplan SD . . . . . . . . . . . . . . . . . .33-32726
Geary DL . . . . . . . . . . . . . . . . . . 2 6 -60084 Hastings L . . . . . . . . . . . . . . . . . . 30-32081 Kaufman J . . . . . . .
Gary DL . . . . . . . . . . . . . . . . . . 2 6.6008S Hatch M . . . . . . . . . . . . . . . . . . . 32-30187 Keelen MH . . . . . .
G a r y DL ................. . 2 6.60086 H a t o m NS . . . . . . . . . . . . . . . . . 32.30414 Kenny TJ ............
Geary DL . . . . . . . . . . . . . . . . . . 26-60087 Hayes SR . . . . . . . . . . . . . . . . . . 32-32309 Kieran PC . . . . . . .
G a r y DL . . . . . . . . . . . . . . . . . . 2 6 .60088 Hazer KA . . . . . . . . . . . . . . . . . . 30-32001 Kisser SL . . . . . . . . . . . . . . . . . . 33-30665
Geary DL . . . . . . . . . . . . . . . . . . 2660089 Heidelberger C . . . . . . . . . . . . . . . 30-31038 KindwaU EP . . . . . . . . . . . . . . . .26.60042
G a r y DL . . . . . . . . . . . . . . . . . .26.60090 Hendncks AC .............. . 2 7 .32296 King JM ...............
Gary DL . . . . . . . . . . . . . . . . . . 2 6 .60091 Hepler DI . . . . . . . . . . . . . . . . . . 27.32068 King JM . . . . . . . . . . . . . . . . . . . 26-60083
Geary DL .................. 26-60123 Hepler DI ................. . 30.3 i530 King JM . . . . . . . . . . . . . . . . . . .26.60084
G a r y DL . . . . . . . . . . . . . . . . . . 26-60124 Hepler DI .................. 30-32002 King JM . . . . . . . . . . . . . . . . . . . 26-60085
Geary DL . . . . . . . . . . . . . . . . . . 2 6-60125 Hepler DI .................. 30-3201 1 King JM . . . . . . . . . . . . . . . . . . . 2 6.60086
Gary DL . . . . . . . . . . . . . . . . . . 2 7 .31349 Hepler DI ................... 27-32130
Gary DL . . . . . . . . . . . . . . . . . .27.31350 Hepler DI . . . . . . . . . . . . . . . . . . . 27-32131 King JM . . . . . . . . . . . . . . . . . . . 26-60088
Geary DL . . . . . . . . . . . . . . . . . . 27-31351 Hermann A ................ . 2 6 -60001 King JM . . . . . . . . . . . . . . . . . . 26-60089
Geary DL . . . . . . . . . . . . . . . . . . 27-31352 Higginsw J . . . . . . . . . . . . . . . . . 32-30418 King JM . . . . . . . . . . . . . . . . . . . 26-60090
Gibson RL . . . . . . . . . . . . . . . . . . 30-31525 Hightower GM .............. .26.60030 King JM . . . . . . . . . . . . . . . . . . . 26-60091
Gillen HW . . . . . . . . . . . . . . . . . . 26-60038 Hill RA .................... 30-31533 King JM . . . . . . . . . . . . . . . . . . .26.60123
Glowa JR . . . . . . . . . . . . . . . . . . 30-32080 Hillman DW . . . . . . . . . . . . . . . . 30-31982 King JM . . . . . . . . . . . . . . . . . . . 26-60124
Goad PT . . . . . . . . . . . . . . . . . . . 30-32063 H i h a n DW ................ 30-32000 King JM . . . . . . . . . . . . . . . . . . . 27-31349
G û l d b w FR . . . . . . . . . . . . . . .27.30700 Hinsdill RD ................. 30-3 1993 King JM . . . . . . . . . . . . . . . . . . .27.31350
Goldstein B . . . . . . . . . . . . . . . . . 2 9.32358 ~ a n ............... 30-32012
H o b e ~ ~ ~AM King JM . . . . . . . . . . . . . . . . . . . 27-31351
Goldskin ED . . . . . . . . . . . . . . . .26.60073 Hofherr LK ................. 39-31095 King JM . . . . . . . . . . . . . . . . . . . 27-31352
Goldstein BD ............... . 2 6 -60074 Holdsworth CE .............. 31-02438 King RW . . . . . . . . . . . . . . . . . . . 30-32000
Goldsteh BD . . . . . . . . . . . . . . . . 33.31094 Holdswoith CE .............. 33-31098 King RW . . . . . . . . . . . . . . . . . . .30-31982
Goldstein BD . . . . . . . . . . . . . . . . 33-31096 Hûldsworth CE .............. 33-31223 Kinkad ER . . . . . . . . . . . . . . . . . 26.60082
GrafíSA ................... 2660048 Holdsworth CE . . . . . . . . . . . . . .34-30857 Kinkead ER . . . . . . . . . . . . . . . . . 2 6.60083
Graiia El ................... 30-32005 Hûldsworth CE .............. 34-32600 KinkeadER . . . . . . . . . . . . . . . . . 26-60084
Grasso P .................. . 3 1.32980 Holdsworth CE ............. . 3 5.30687 Kinkead ER . . . . . . . . . . . . . . . . . 26-60085
Greenberg HL .............. .26-60029 Holland JM ................. 30-31536 Kinkead ER . . . . . . . . . . . . . . . . . 2 6-60086
Gruenke LD . . . . . . . . . . . . . . . . . 33-32727 Holland JM ................. 30-31983 Kinkead ER . . . . . . . . . . . . . . . . . 26.40087
Gruenke . . . . . . . . . . . . . . . . . 33-32910 Holmberg R . . . . . . . . . . . . . . . . . 30-31531 K i n k 4 ER . . . . . . . . . . . . . . . . . 26-60089

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 0732290 0 5 4 9 9 6 2 867

Kinkead ER . . . . . . . . . . . . . . . . . 26-60123 McGinniss UT . . . . . . . . . . . . . . . 26-31781 . . . . . . . . . . . .40.32761


Kinkead ER . . . . . . . . . . . . . . . . .26-60124 Mcüregor 3 . . . . . . . . . . . . . . . . . 41-30735 . . . . . . . . . . . . 30.31995
Kitchen DN . . . . . . . . . . . . . . . . . 30-32845 McKee HC . . . . . . . . . . . . . . . . .26-60057 Pearson WH . . . . . . . . . . . . . . . . 33-30665
Kitchen DN . . . . . . . . . . . . 32-30413 McKee RH . . . . . . . . . . . . . . . . . 36-33132 Peterson JE . . . . . . . . . . . . . . . . .26-60001
Klan MJ . . . . . . . . . . . . . . . . . . . 39-31651 McKelvey JA . . . . . . . . . . . . . . . . 27-31528 Peterson JE . . . . . . . . . . . . . . . . . 26-60106
Klein JP . . . . . . . . . . . . . . . . . . . 26.60043 Mciaughlin JK . . . . . . . . . . . . . . 32-30419 Phillips RD . . . . . . . . . . . . . . . . . 30-32063
Kleinman MT . . . . . . . . . . . . . . .26.60094 Mecler FJ . . . . . . . . . . . . . . . . . . 27-32173 Phillips RD . . . . . . . . . . . . . . . . . 32-30408
Kleinman MT . . . . . . . . . . . . . . .27-30841 Mecler FJ . . . . . . . . . . . . . . . . . . 27-32174 ... 32-304 10
NOMe DR . . . . . . . . . . . . . . . . . 34-32600 Mecler FJ . . . . . . . . . . . . . . . . . . 27-32175 . . . . . . . . . 33-31098
Kluge A . . . . . . . . . . . . . . . . . . . 30-31603 Mecler FJ . . . . . . . . . . . . . . . . . . 27-32176 Piccirillo VJ . . . . . . . . . . . . . . . . . 37-31958
Knapinski PJ . . . . . . . . . . . . . . . . 27-32173 Mecler FJ . . . . . . . . . . . . . . . . . . . . .. 26.60080
Kneip TJ . . . . . . . . . . . . . . . . . . . 26-60094 Mecler FJ . . . . . . . . . . . . . . . . . . 3 0.32003 Pias LL .................... 30-31537
Kneip TJ . . . . . . . . . . . . . . Mix MC . . . . . . . . . . . . . . . . . . . 32-32656 Piankenhorn L . . . . . . . . . . . . . . .37-3 1958
Kneip TJ . . . . . . . . . . . . . . . . . . . 30-31647 Monson RR . . . . . . . . . . . . . . . . . 31-30449 Platte LR . . . . . . . . . . . . . . . . . . . 26-60048
Kozbelt SJ . . . . . . . . . . . . . . . . . . 27-3 1528 Morgan RW . . . . . . . . . . . . . . . . . 30-3 i639 Politzer IR . . . . . . . .
KNmm AA . . . . . . . . . . . . . . . . . 27-30704 Morgan RW . . . . . . . . . . . . . . . . . 32-32565 Poole C . . . . . . . . . .
W O V E N . . . . . . . . . . . . . . . . . .31-02438 Monis A . . . . . . . . . . . . . . . . . . . 31-30265 Ptyor GT . . . . . . . . . . . . . . . . . . . 30-32007
Lang0 TM . . . . . . . . . . . . . . . . . . 27-32173 Monis MJ . . . . . . . . . . . . . . . . . . 37-31152 Ptyor GT . . . . . . . . . . . . . . . . . . . 30-32008
h e t e r JL . . . . . . . . . . . . . . . . . . 32-32651 Muir CS . . . . . . . . . . . . . . . . . . .32-30418 Ptyor GT . . . . . . . . . . . . . . . . . . . 30-32009
Laskin S . . . . . . . . . . . . . . . . . . . E.60074 Munson AE . . . . . . . . . . . . . . . . .32-31512 Putman DL . . . . . . . . . . . . . . . . . 35-32432
Laskin S . . . . . . . . . . . . . . . . . . .2660076 Munson AE . . . . . . . . . . . . . . . . . 33-31750 Putman DL . . . . . . . . . . . . . . . . .35-32433
Laskin S . . . . . . . . . . . . . . . . . . . 29.32358 Myers RC .................. 2640087 Putman DL . . . . . . . . . . . . . 35-32479
Laskin S . . . . . . . . . . . . . . . . . . . 33-31096 Myers RC . . . . . . . . . . . . . . . . . .26-60088
Lawrie J A . . . . . . . . . . . . . . . . . .2640039 Myers RC . . . . . . . . . . . . . . . . . . 26-60089
Leong BKJ . . . . . . . . . . . . . . . . . 26.60076 Myers RC ................. . 26.60090
Leong BKJ . . . . . . . . . . . . . 26-60077 Myers RC . . . . . . . . . . . . . . . . . .26.60091
Levine L . . . . . . . . . . . . . . . . . . . 37.31136 Myers RC . . . . . . . . . . . . . . . . . . 27-31349 Putman DL . . . . . . . . . . . . . . . . . 37-3 1152
Lewis SC . . . . . . . . . . . . . . . . . . 30-31982 Myers RC . . . . . . . . . . . . . . . . . . 2 7 .31350 Putman DL . . . . . . . . . . . . . . . . . 37-31830
Lewis SC . . . . . . . . . . . . . . . . . . 30-32000 Myers RC . . . . . . . . . . . . . . . . . . 27-31351 Quillen JL . . . . . . . . . . .
Lewis SC . . . . . . . . . . . . . . . . . .30-32063 Myers RC . . . . . . . . . . . . . . . . . . 27-31352 Q u h B . . . . . . . . . . . . . . . . . . . 37-31958
Lewis SC .................. 34-30330 Nachreiner DI . . . . . . . . . . . . . . . 26-60087 Q u h TP . . . . . . . . . . . . . . . . . . 34-32982
Lijinsky W . . . . . . . . . . . . . . . . . 26-60080 Nachreiner DJ . . . . . . . . . . . . . . . 26-60088 Raabe GK . . . . . . . . . . . . . . . . . . 32-3M20
Linn WS . . . . . . . . . . . . . . . . . . . 26.6045 Nachreiner DJ . . . . . . . . . . . . . . .26.60089 Radford EP . . . . . . . . . . . . 27-30965
Linn WS . . . . . . . . . . . . . . . . . . . 28-22073 Nachreiner DJ . . . . . . . . . . . . . . . 2 6.60090 Raha CR . . . . . . . . . . . . . . . . . . .26-60080
Lioy PJ . . . . . . . . . . . . . . . . . . . .28.31614 Nachreiner DJ . . . . . . . . . . . . . . .26.60091 Rahimtula AD . . . . . . . . . . . . . . . 30-3 1995
Lippman M . . . . . . . . . . . . . . . . . 2 6.60094 Nachreiner DJ . . . . . . . . . . . . . . . 27-31349 Ramahi H . . . . . . . . . . . . . . . . . . 26-60080
Lipsky MM . . . . . . . . . . . . . . . . . 32-30417 Nachreiner DJ . . . . . . . . . . . . . . . 27-3 1350 Rappaport H ................ 26.60080
Lipsky MM . . . . . . . . . . . . . . . . . 32-30421 Nachreiner DJ ............... 27-31351 Rebert CS . . . . . . . . . . . . . . . . . . 30-32006
Litovitz T . . . . . . . . . . . . . . . . . . 36-31914 Nachreiner DJ ............... 27-31352 Rebert CS . . . . . . . . . . . . . . . . . . 30-32007
Litovitz T . . . . . . . . . . . . . . . . . . 39-31093 Nakatani RE . . . . . . . . . . . . . . .. 33.30601 Rebert CS . . . . . . . . . . . . . . . . . . 30-32008
Lock S .................... 30-31531 Nakatani RE ................ 34-32982 Rebert CS . . . . . . . . . . . . . . . . . . 30-32077
L U C ~SVS . . . . . . . . . . . . . . . . . . 31-31471 Nakatani RE . . . . . . . . . . . . . . . . 40-33133 Reitman FA . . . . . . . . . . . . . . . . .39-31651
LUllim G . . . . . . . . . . . . . . . . . . 37-31154 Neeper-Bradley TL . . . . . . . . . . . . 36-33318 Rench ID . . . . . . . . . . . . . . . . . -40-32427
Lundberg GW . . . . . . . . . . . . . . . 32-32309 Neeper-Bradley TL . . . . . . . . . . . . 36-33319 Renne RA . . . . . . . . . . . . . . . . . . 32-30626
Lyinsky W . . . . . . . . . . . . . . . . . . 26-60122 Neeper-Bradley TL ............ 38-31216 Riddick R . . . . . . . . . . . . . . . . . . 26-6W94
LYSYHH ................... 32-31512 Neeper-Bradley TL . . . . . . . . . . . . 38-31217 Robbins WK . . . . . . . . . . . . . . . . 2 7 .33264
MacFarìand HN .............. 30-3 1535 Neff JM . . . . . . . . . . . . . . . . . . . 26-60030 Robinson E . . . . . . . . . . . . . . . . . 26-60070
MacFariand HN . . . . . . . . . . . . . . 30-3 199 1 Neff JM . . . . . . . . . . . . . . . . . . . 27-32178 Robinson K . . . . . . . . . . . . . . . . . 37-3 1153
MacFariand HN . . . . . . . . . . . . . .32-30412 Neff JM ................... 33-32871 Robinson K . . . . . . . . . . . . . . . . . 37-3 1154
Macûregor JA ............... 32-31299 Nevissi AE . . . . . . . . . . . . . . . . . 33-30601 Rocke TE . . . . . . . . . . . . . . . . . . 30-3 1993
Macûregor JT . . . . . . . . . . . . . . .41-30101 Nevissi AE ................. 34-32982 Rockweii TH . . . . . . . . . . . . . . . .26.60049
MacMahon B . . . . . . . . . . . . . . . . 31-30449 Newbeme P . . . . . . . . . . . . . . . . . 31-31480 Rodkey FL . . . . . . . . . . . . . . . . .27 .30700
MacNaughton MG ............ 32-30415 Newton PE . . . . . . . . . . . . . . . . . 2 6 -60043 Rose W .................... 40-32424
Maibach HI . . . . . . . . . . . . . . . . . 33-32727 Newton PE . . . . . . . . . . . . . . . . .27.30705 Rosenberg NL . . . . . . . . . . . . . . .39-30623
......... 33-32910 Newton PE . . . . . . . . . . . . . . . . . 37-31151 Rossi SS . . . . . . . . . . . . . . . . . . .26-6002
M&¡s SL ................. . 2 7 .32176 Nguyen Tû . . . . . . . . . . . . . . . . . 27-32179 Rothenberg SJ . . . . . . . . . . . . . . . 34-33036
Mallan RP . . . . . . . . . . . . . . . . . . 30-31647 NoRykû JM ................. 39-31651 R o h a n KI . . . . . . . . . . . . . . . . . 37-31136
M d o n RP . . . . . . . . . . . . . . . . . . 31-30264 O’Brien PJ . . . . . . . . . . . . . . . . . . 30-3 1995 Royal TM . . . . . . . . . . . . . . . . . .26 .60051
Mandak D . . . . . . . . . . . . . . . . . . 33-31598 O’Connor JM . . . . . . . . . . . . . . . . 40-30741 Rüdnick J . . . . . . . . . . . . . . . . . . 27.33273
Marshd WF . . . . . . . . . . . . . . . . 30-31998 O’Sh- WJ . . . . . . . . . . . . . . . . . 34-30857 Rusch GM . . . . . . . . . . . . . . . . . . 2 6 .60076
Mauderly JL . . . . . . . . . . . . . . . . 34-33036 Osborne BE ................ . 37.31153 Rushton L . . . . . . . . . . . . . . . . . . 31-30449
McAuliffe DJ . . . . . . . . . . . . . . . . 33-31225 Ottoboni F .................. 26-60060 Safioth U . . . . . . . . . . . . . . . . .. 2 6.60080
McCleilan RO ............... 34-33036 Palmes ED .................. 2660023 S.do EO . . . . . . . . . . . . . . . . . . . 3 3.30601

3
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 'i5 M 0732290 0 5 4 î î b 3 7 T 3

Sample CJ . . . . . . . . . . . . . . . . . . 35-3 1189 Springfield KA . . . . . . . . . . . . . . . 36-32641 Voelz GL . . . . . . . . . . . . . . . . . . 27.33273


San RHC . . . . . . . . . . . . . . . . . . . 36-32641 Squibb KS . . . . . . . . . . . . . . . . . .40.30741 Walicave L . . . . . . . . . . . . . 26-60122
Satterfield MH . . . . . . . . Stefanchik-Scott V . . . . . . . . . . . . 32-30187 Ward GS . . . . . . . . . . . . . . . . . . . 26-60002
ScaiaR .................... 32-30422 Stein ZA . . . . . . . . . . . . . . . 32-30187 Warne TM . . . . . . . . . . . . . . . . . . 32.30414
Schaumberg HH . . . . . . . . . . . . . . 30-32079 . 27-32132 Warner JS . . . . . . . . . . . . . . .
Schaumburg HH . . . . . . . . . . . . . . 39-30623 Stemmer KL . . . . . . . . . . . . . . . . 30-31999
Schmitt S . . . . . . . . . . . . . . . . . . 36-33132 Stewart DJ . . . . . . . . . . . . . . . . . . 26-60043
Schottenfeld D . . . . . . . . . . . . . . .27-32467 . . . . . . . . . . . . .26-60048
Schreiner CA . . . . . . . . . . . . . . . . 30-3 1997 . . . . . . . . . . . . .26-60106 WansJD ......
Schreiner CA . . . . . . . . . . . . . . . . 36-33132 Stewart RD . . . . . . .
Schroeder HA . . . . . . . . . . . . . . . 26-601 10 Stewart RD . . . . . . . Weaver NK . . . . . . . . . . . . . . . . . 30-3 1525
Schroeder HA . . . . . . . . . . . . . . . 26-601 11 Stewart RD . . . . . . . . . . . . . . . . .26-60043 Weaver NK . . . . . . . . . . . . . . . . . 3 1-021138
. . . . . . . . . .26-60112 Stewart RD . . . . . . . . . . . . . . . . . 2 6 .60048 Weir BR . . . . . . . . . . . . . . . . . . . 34-32923
Schroeder HA . . . . . . . . . . . . . . . 2 6-60113 Stewart RD . . . . . . . . . . . . . . . . . 2 7 .30705 Weir FW . . . . . . . . . . . . . . . . . . . 2 6.60022
. . . . . . . . . . 26-60114 Stewait TA . . . . . . . . . . . . . . . . .24.30057 Weir FW . . . . . . . . . . . . . . . . . . . 26-60023
. . . . . . . . . . 26-60115 . . . . . . . . . . . . ..27 .30705 WeirFW . . . . . . . . . . . . . . . . . . . 26-60049
Schroeder RE . . . . . . . . . . . . . . . . 33-31095 . . . . . . . . . . . . . . 32-32502 Weisfeldt ML . . . . . . . . . . . . . . . .27-30965
Schroeder RE . . . . . . . . . . . . . . . . 35-30687 Sullivan LJ . . . . . . . . . . . . . . . . . 26.60082 Wen CP . . . . . . . . .
Schulte HF . . . . . . . . . . . . . . . . .27-33273 Sullivan LJ . . . . . . . . . . . . . . . . . 26-60083 Wester RC . . . . . . . . . . . . . . . . . . 33-32727
Schwartz GP . . . . . . . . . . . . . . . . 28-31614 Sullivan LJ . . . . . . . . . . . . . . . . .26.60084 Wester RC . . . . . . . . . . . . . . . . . . 33-32910
Segal A . . . . . . . . . . . . . . . . . . . . 29.32681 Sullivan LJ . . . . . . . . . . . . . . . . . 2 6 -60085 white KL . . . . . . . . . . . . . . 32-31512
Seigneur C . . . . . . . . . . . . . . . . . .32-32309 Sullivan LJ . . . . . . . . . . . . . . . . . 2 6-60086 white KL . . . . . . . . . . . . . . 33-31750
Seigneur C . . . . . . . . . . . . . . . . . . 34-32923 Sullivan LJ . . . . . . . . . . . . . . . . . 2 6.60087 WhiteLE . . . . . . . . . . . . . . . . . . 30-32078
Seiler FA . . . . . . . . . . . . . . . . . . . 34-33036 Sullivan LJ . . . . . . . . . . . . . . . . . 26-60088 WhihIIan RP . . . . . . . . . . . . . . . . 33-30601
Sellakumar A . . . . . . . . . . . . . . . . 33-3 1096 Sullivan U . . . . . . . . . . . . . . . . . 26.60089 WhitmmRP . . . . . . . . . . . . . . . . 34-32982
Sellakumar AR . . . . . . . . . . . . . . . 33-31094 Sullivan LJ . . . . . . . . . . . . . . . . . 26-60090 . . . . . . . . . . . . . 4 0.33133
Sharratt M . . . . . . . . . . . . . . . . . . 31-32980 Sullivan LJ ................ .26.60091 Wilson KW . . . . . . . . . . . . . . . . . 26.60052
Shubik P . . . . . . . . . . . . . . . . . . . 26-60080 Sullivan W . . . . . . . . . . . . . . . . . 2 6.60123 Wingate DA . . . . . . . . . . . . . . . . 30-3201 1
Shubik P . . . . . . . . . . . . . . . . . . . 2 6.60122 Sullivan LJ ................ . 26.60124 Winward MR . . . . . . . . . . . .
Sica EW . . . . . . . . . . . . . . . . . . . 30-3 1996 Sullivan LJ . . . . . . . . . . . . . . . . . 26-60125 Woiman SR . . . . . . . . . . . . .
Siconolfï RM . . . . . . . . . . . . . . . . 30-32064 Sullivan LJ . . . . . . . . . . . . . . . . .27.31349 Wolman SR . . . . . . . . . . . . .
Sigler CI . . . . . . . . . . . . . . . . . . .36-3 1911 Sullivan U . . . . . . . . . . . . . . . . .27-31350 Wolman SR . . . . . . . . . . . . .
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Sigler CI ................... 37-30618 Sullivan LJ . . . . . . . . . . . . . . . . . 27-31351 wong O . . . . . . . . . . . . . . . . . . . 30-3 1639


S i g h CI . . . . . . . . . . . . . . . . . . . 37-30619 Sullivan U ................ . 2 7 .31352 . . . . . . . . . . . 32-32565
Sigler CI . . . . . . . . . . . . . . . . . . . 37-30620 Sullivan LJ . . . . . . . . . . . . . . . . . 27-3 1528 wong O . . . . . . . . . . . . . . . . . . . 41-32613
Sigler CI . . . . . . . . . . . . . . . . . . . 37-31149 Swanson M ................. 36-33132 Wong ZA . . . . . . . . . . . . . . . . . . 36-33132
Sigler CI . . . . . . . . . . . . . . . . . . . 37-3 1150 Tabershaw IR . . . . . . . . . . . . . . . . 26-60060 Woodruff DL . . . . . . . . . . . . . . . . 33-30665
. . . . . . . . . . . . . . . 36-31909 Tanski W . . . . . . . . . . . . . . . . . . 26.60025 Worrell N R . . . . . . . . . . . . . . . . . 39-32387
. . . . . . . . . . . . . . . 36-31910 Tatem HE .................. 2660030 Wright WB . . . . . . . . . . . . . . . . . 26-60117
Sigler CI .................... 36-31912 TeVauit RK . . . . . . . . . . . . . . . . . 30-32063 Wu A ............
Sigler CI .................... 37-31487 Thomas FB ................. 33-31223 Wu A . . . . . . . . . . . .
Skis& CM . . . . . . . . . . . . . . . . . . 39-31651 Thomas MD . . . . . . . . . . . . . . . . 26-60108 Wu A . . . . . . . . . . . .
Slauter RW . . . . . . . . . . . . . . Tietze Pü . . . . . . . . . . . . . . . . . . 39-31651 Yang LL . . . . . . . . . . . . . . . . . . . 35-32480
Slymen D . . . . . . . . . . . . . . . . . . 39.31095 T ~ m a t iL~ ................. .26.60080 Yang LL . . . . . . . . . . . . . . . . . . . 35-32481
Smith CW . . . . . . . . . . . . . . . . . . 30-31525 Tommerdahi JB .............. 26-60051 Young RR . . . . . . . . . . . . . . . . .. 35.30935
Smith EM . . . . . . . . . . . . . . . . . . 26-60031 Tûth B . . . . . . . . . . . . . . . . . . . . 2 6 .60080 Yuill TN . . . . . . . . . . . . . . . . . . . 30-3 1997
Smith JH . . . . . . . . . . . . . . . . . . . 39-31651 Travis CC .................. 36-31431 ïakhari S . . . . . . . . .
Smith RG . . . . . . . . . . . . . . . . . . 2 6 -60062 Trent L . . . . . . . . . . . . . . . . . . . . 4 1.32613 Zedeck MS ................ . 2 8.30174
Smith RG ................. . 2 6 -60064 Trosset RP . . . . . . . . . . . . . . . . . .27 .30915
Smith TJ . . . . . . . . . . . . . . . . . . . 4 1.31765 TnmipBF .................. 32-30421
Snyder BP .................. 33-30601 T ~ a iSP .................... 32-30411
Snyder CA . . . . . . . . . . . . . . . . . . 2660075 Tyler TR . . . . . . . . . . . . . . . . . . . 27-31528
Snyder CA . . . . . . . . . . . . . . . . . . 33-31094 Uddin DE . . . . . . . . . . . . . . . . . . 32-30415
Snyder CA . . . . . . . . . . . . . . . . . . 33-31096 Ulnch CE . . . . . . . . . . . . . . . . .. 2 7 .32610
Snyder L J . . . . . . . . . . . . . . . . . . 26.60036 Ulnch CE .................. 34-32600
Snyder NK . . . . . . . . . . . . . . . . . 33-31095 Valie BL ................. . 26.60065
Sorenson SS . . . . . . . . . . . . . . . . 30-32006 V a l l e BL ................. . 26.60066
Sorenson SS . . . . . . . . . . . . . . . . 30-32077 . . . . . . . . . 2 6.60067
Spencer PS ................. 29-32291 Valle BL . . . . . . . . . . . . . . . . . . 26-60068
Spencer PS ................. 30-30223 Valle BL .................. 26-60069
Spencer PS ................. 30-30225 Vandemeulen JH ............. 39-31089
Spencer PS ................. 30-30226 Vemot EH .................. 39-31651
Spencer PS ................. 30-32004 Vetrano K . . . . . . . . . . . . . . . . . . 40-06424

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
ORGANIZATION INDEX

Albert Einstein College of Medicine . . . . . . . . . . . . . . . . . . 29-32291 Bio-Research Laboratories Ltd. . . . . . . . . . . . . . . . . . . . . . 37-3 1i54
Albert Einstein College of Medicine . . . . Biodynamics Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . 27-30765
Albert Einstein College of Medicine . . . . Biodynamics ínc. . . . . . . . . . . . . . . . . . . . . . . . . . . . 33-31095
Alben Einstein College of Medicine . . . . Biospherics Inc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-3023 i
Albert Einstein College of Medicine . . . . Bomston Laboratories Inc ......................... 30-32296
Albert Einstein College of Medicine. Yeshiva University . . . 30-30223 Bomston Laboratories Inc . . . . . . . . . . . .
Albert Einstein College of Medicine. Yeshiva University . . . 30-30225 Bomston Laboratories inc . . . . . . . . . . . . . . . . . . . . . 30-32298
Albert Einstein College of Medicine. Yeshiva University . . . 30-30226 Bomston Laboratories Inc . . . . . . . . . .
American Petroleum Institute ....................... 27-32178 Bomston Laboratories Inc ......................... 30-32853
American Petroleum Inst . Environmental Affairs . . . . . . . . . 26-60108 Bomston Laboratones Inc ......................... 30-32854
American Petroleum Inst . Environmental Affai Bomston Laboratories Inc ......................... 32-30966
American Public Health Assoc. . . . . . . . . . . . . . . . . . 26-60108 Bomston Laboratories Inc ......................... 32-31048
Amococorp ...................... British Petroleum Co. P.L.C. ....................... 31-32980
Amoco Cop Exp. Pathol. Lab. . . . . . . . . . Brookhaven National Laboratory . . . . . . . . . . . . . . . . . . . -32-32855
Amoco Corp....................... Bushy Run Research Center ....................... 33-32009
Amoco C o p ...................... Bushy Run Research Center ....................... 38-31216
O CO.................................
A ~ O COil . 32.30414 Bushy Run Research Center ....................... 38-31217
O COP ................................
A ~ O COil 33-31223 California University of Berkeley . . . . . . . . . . . . . . . . . . . . 26-60060
Applied Health Sciences ......................... . 4 1-32613 California University of Berkeley .................... 30-31992
Arkansas University of for Medical Sciences . . . . . . . . . . . . 30-32063 California University of Irvine ...................... 30-3 1534
Arkansas University of for Medical Sciences . . . . . . . . . . . . 30-32836 California University of School of Medicine . . . . . . . . . . . . 33-32727
Armed Forces Institute of Pathology . . . . . . . California University of School of Medicine . . . . . . . . . . . . 33-32910
Armed Forces Radiobiol. Res . Inst. . . . . . . . . California University of School of Phamacy . . . . . . . . . . . . 33-32727

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Bartiesville Energy Techno1. Cent.................... 30-3 1998 California University of School of Pharmacy . . . . . . . . . . . . 33-32910
Battelle Columbus Laboratories . . . . . . . . 30-31992 California University of School of Public Health . . . . . . . . . 33-71163
Battelle Columbus Laboratories ..................... 31-31471 Cannon Laboratories . . . . . . . . . . . . . . . . . . .
Battelle Marine Research Laboratory . . . . . . . . . . . . . . . . .33-30665 Carnegie-Mellon Inst. Res . . . . . . . . . . . . . . .
Battelle Marine Research Laboratory . . . . . . . . . . . . . 33-30665 Carnegie-Melion Inst. Res . . . i . . . . . . . . . . .
Battelle Marine Research Laboratory . . . . . . . . . . . . . 33-32871 Carnegie-Mellon Inst. Res . . . . . . . . . . . . . . .
Battelle Memorial Institute, Pacific Northwest Labs. Carnegie-Mellon Inst. Res. . . . . . . . . . . . . . . . . . . . . . . . . 26-60085
Battelle Memorial Institute. Pacific Northwest Labs. . . . . . . . 2640050 Carnegie-Mellon inst.Res . . . . . . . . . . . . . . . . . . . . . . . . . 26-60086
Battelle New England Marine Research Laboratory . . . . . . . 33-32871 Carnegie-Mellon Inst. Res . . . . . . . . . . . . . . . . . . . . . . . . . 26-60087
Battelle Pacific Northwest Laboratories . . . . . . . . . . . . . . . . 32-30626 Carnegie-Mellon Inst. Res . . . . . . . . . . . . . . . . . . . . . . . . . 26-60088
Battelle Washington Environmental Program o f f i c e . . . . . . . 40-32427 Carnegie-Mellon Inst. Res ......................... 26-60084,
Bedford Institnte of Oceanography/€’. Lane & Associ . . . . . . 39-31089 Carnegie-Mellon Inst. Res. . . . . . . . . . . . . . . . . . . . . . . . . 26-60090
Bedford Institute of OœanographyP. Lane & Associ . . . . . . 39-31089 Carnegie-Mellon Inst. Res . . . . . . . . . . . . . . . . . . . . . . . . . 26-60091
Bellewe Hosp .................................. 26-60093 Carnegie-Mellon Inst . Res. . . . . . . . . . . . . . . . . . . . . . . . . 26-60123
BIBRA Toxicology International .................... 39-32387 Carnegie-Mellon Inst Res ......................... 26-60124
Bio/dynamics Inc .............................. . 2 8-30077 Carnegie-Mellon Inst. Res ......................... 26-60]25
Bio/dynamics inc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28-3 1209 Carnegie-Mellon University ........................ 27-3 1349
Bio/dynamics Inc .............................. . 28.31210 Carnegie-Melion University ........................ 27-3 1350
Bio/dynamics Inc . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28-31211 Carnegie-Mellon University ....................... . 2 7 -31351
Bio/dynamics Inc . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28-31212 Carnegie-Mellon University . . . . . . . . . . . . . . . . .
Bio/dynamin Inc ............................... 31-31481 Carnegie-Meiion University . . . . . . . . . . . . . . . . .
Bio/dynamics Inc .............................. . 3 2-30235 .
Chemical Industr Ins.t Toxic01...................... 30-32005
Bio/dynamin Inc ............................... 32-30236 Chemical Manufacturers Association . . . . . . . . . . . . . . . . . 28-3121 1
Bio/dynamics Inc ............................... 32-30237 Chemical Manufacturers Association . . . . . . . . .
Bio/dynamin Inc ............................... 32-30238 Chevron Environ. Health Cent...................... 32-3 1299
Bio/dynamics Inc ............................... 32-30239 Chevron Environ. Health Cent...................... 36-33132
Bio/dynamin Inc. . . . . Chicago Mech . Sch.............................. 26-60080
Bio/dynamics inc . . . . . Cincinnati University of .......................... 26-60025
Bio/dynamics Inc............................... . 4 1-33232 Cincinnati University of .......................... 27-30915
BioDynamics Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37-31151 Cincinnati University of College of Medicine . . . . . . . . . . . 30-32081
BioDynamics Inc........................... Cincinnati University of Kettering Lab. . . . . . . . . . . . . . . . . 26-60028
BioDynamics Inc............................... 37-32486 Cincinnati University of Kettering Lab. . . . . . . . . . . . . . . . . 31-02438
Bio-Labs Inc ................................... 32-30413 Cincinnati University of Kettering Lab. Medical Center . . . . 33-32725
Bio-Research Laboratories Ltd...................... 37-31153 Cincinnati University of Medical Center . . . . . . . . . . . . . . . 27-32132

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*:4634 95 = 0 7 3 2 2 9 0 0547965 5’76

Cincinnati University of Medical Center . . . . . . . Elars Bioresearch Laboratories . . . . . . . . . . . . . . . . . . .


Cincinnati University of Medical Center . . . . . . . . . . . . . . . 30-3 1999 Elars Bioresearch Laboratories ...................... 29-33067
Cincinnati University of Medical Center . . . . . . . . . . . . . . . 30-32849 Elars Bioresearch Laboratones . . . . . . . . . . . . . . . . . . . . . . 29-33068
Cincinnati University of Medical Center . . . . . 30-32851 Elars Bioresearch Laboratories . . . . . . . . . . . . .
Clayton Environmental Consultants . . . . . . . . . . . 40-31953 Elars Bioresearch Laboratories . . . . . . . . . . . . .
Clayton Environmental Consultants inc . . . . . . . . . . . . . . . . 36-30038 Elars Bioresearch Laboratories . . . . . . . . . . . . . . . . . . . . . . 29-33 106
Colorado University of School of Medicine . . . . . . Elars Bioresearch Laboratories
Colucci & Associates Inc . . . . . . . . . . . . . . . . . . Elars Bioresearch Laboratories I
Colucci & Associates lnc . . . . . . . . . . . . . . . . . . . . . . . . . 32-32502 Electric Power Research institute . . . . . . . . . . . . . . . . . . . . 27-30840
Colucci & Associates Inc . . . . . . . . 32-32503 ENSR Health Sciences . . . . . . . . . . . . 39-334x4
Columbia University .. ENSR Health Sciences . . . . . .
Columbia university . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-30187 Enviro Control inc . . . . . . . . .
COMEX . . . . . . . . . . . . . . . . Environ . Ind . Safety Consult. . . . . . . . . . . . . . .
CONCAWE . . . . . . . . . . . . . Environmental Health Associates
Coordinating Research Council Inc . . . . . . . . . . . . . . . . . . . 27-30705 Environmental Health Associates
Coordinating Research Council inc . . . . . . . . . . . . . . . . . . . 27-30839 Environmental Health Associates
Coordinating Research Council inc . . . . . . . . . . . . . . . . . . . 27-30841 Environmental Health Associates Inc . . . . . . . . . . . . . . . . . 32-32565
Coordinating Research Council Inc . . . Epidemiology Resources inc . . . . . . . . . . . . . . . . . . . . . . . 3 1-3 1480
Coordinating Research Council Inc . . . . . . . . . . . . . . . . . . . 27.30965 Epidemiology Resources Inc ....................... 32-32225
Coordinating Research Council inc . . . . . . . . . . . . . . . . . . .27-30966 Epidemiology Resources inc . . . . . . . . . . . . 7-31336
Coordinating Research Council inc . . . . . . . . . . . . . 28-33073 Eppiey Inst. for Res . in Cancer & Allied Diseas 0-3 1646
Coordinating Research Council inc . . . . . . . . . . . . . 30-31639 Equitable Environmental Health. Inc. . . . . . . . . . . . . . . . . . 26-60120
Coordinating Research Council inc . . . . . . . . . . . . . . . . Experimental Pathology Laboratories . . . . . . . . . . . . . . . . .30-3 1535
Coordinating Research Council inc . . . . . . . . . . . . . . . . Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 27-30704
Copley International Corp. . . . . . . . . . . . . . . . . . . . . . . . . . 26-60052 Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 32-30407
Copley International Corp......................... . 2 6 -60079 Experimental Pathology Laboratories inc . . . . . . . . . . . . . . . 32-30408
Cornell University Medical College . . . . . . . . . . . . . . . . . .27-32467 Experimental Pathology Laboratories Inc. . . . . . . . . . . .
Cornell University Medical S Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 33-3 1642
Cox Associates . . . . . . . . . Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 33-3 1695
Dartmouth Medical School . . . . Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 33-31696
Dartmouth Medical School Experimental Pathology Laboratories Inc. . . . . . . .
1)artmouth Medical School . . . . . . 26-60112 Experimental Pathology Laboratones Inc. . . . . . . .
Dartmouth Medical School Experimental Pathology Laboratories Inc. . . . . . . . . . . . . . . 37-31 148
Dartmouth Medical School Exxon Biochemical Sciences Inc..................... 39-31651
Dartmouth Medical School ....................... . 26-60115 Exxon Biomedical Sciences Inc. . . . . . . . . . . . . . . . . . . . . . 35-30647
Deutsche Gesellschaft für Minerdölwissenschaft & Kohlechemie eV see Exxon Biomedical Sciences ìnc . . . . . . . . . . . . . . . . . . . . . . 36-33132
DGMK Exxon Co. U.S.A. ............................... 32-01363
DGMK ................................... E n o n Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-3 1982
DGMK ................................... Exxon Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-32000
Diamond Shamrock Corp......................... .27 -31528 Exxon Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-32063
Diamond Shamrock Corp.......................... 30-31982 Exxon Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31-32162
Diamond Shamrock Corp.......................... 30-32000 Exxon Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-30408
Duquesne University . . . . . . . . . . . . . . . . . . . . . . . . . 4 0 -30740 Exxon Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34-30330
Duquesne University ............................ .40-30740 Exxon Corp., Res . Environ . Health Div . . . . . . . . . . . . . . . . 32-30410
Dynamac Corp ................................. 30-32013 Exxon Corp.. Res . Environ. Health Div . . . . . . . . . . . . . . . . 32-32502
Dynamac Corp ................................ . 3 2-31555 Exxon Research & Engineering Co. . . . . . . . . . . . . . . . . . . 27-33264
Dynamac C o p Enviro Control Division ............... 29-32809 Exxon Research & Engineering Co. . . . . . . . . . . . . . . . . . . 35-30687
EA Engineering Science & Technology Inc . . . . . . . . . . . . . 32-30599 General Motors Corp............................ . 26-60001
EA Engineering Science & Technology Inc . . . . . . . . . . . . . 32-30600 Georgetown University Hospital ..................... 39-31093
EA Engineering Science & Technology Inc . . . . . . . . . . . . . 34-3303 i Gulf Corp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31-30449
Elars Bioresearch Laboratories ...................... 27-32068 Gulf Oil Corp.................................. 30-3 1525
Elan Bioresearch Laboratories ...................... 27-32130 Gulf Oil COT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10-32064
Elars Bioresearch Laboratories ..................... . 2 7 -32131 Gulf Oil Corp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 -30449
Elars Bioresearch Laboratories ...................... 2î-32771 Gulf Oil C o p . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-7041 1
Elan Bioresearch Laboratories ..................... . 2 7-32772 Gulf Research & Development Co ...
Elars Bioresearch Laboratories ..................... .27 -32773 Gulf Research & Development Co . . . . . . . . . . . . . . . . . . . 29-32615
Eiars Bioresearch Laboratories ...................... 27-32774 Gulf Research & Development Co . . .
Elars Bioresearch Laboratories ...................... 27-32813 Gulf Science & Technology Co..................... . 2 7 .32132
Eiars Bioresearch Laboratories ...................... 27-32814 Gulf Science & Technology Co...................... 29-32668
Elars Bioresearch Laboratories . . . . . . . . . . . . . . . . . . . 27.32815 Gulf Science & Technology Co...................... 30-31535
Elan Bioresearch Laboratories ..................... .27 -32816 Gulf Science & Technology Co...................... 30-31991
Elan Bioresearch Laboratories ...................... 27-32817 Harvard Medical School ......................... . 2 6-60065
Elars Bioresearch Laboratories ...................... 29-33065 Harvard Medical School ......................... . 2 6 -60066

6
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL84634 95 0 7 3 2 2 9 0 O549966 4 0 2

Harvard Medical School ......................... . 26.60067 Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 34-30636
Harvard Medical School ......................... . 26.60068 Hazleton Laboratories America Inc . . . . . . . . . . . . .
Harvard Medical School ......................... . 26.60069 Hazleton Laboratories America inc . . . . . . . . . . . . . . . . 34-32776
Harvard Medical School . . . . . . . . . . . . 30-32080 Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 34-32777
Harvard M e d i d School . . . . . . . . . . . . 33-31225 Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 34-32778
Harvard University . . . . . . . . . . . . . . . . 26-60116 Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 34-32779
Hawaii University of School of Medicine . . . . . . . . . . Hazleton Laboratories America inc . . . . . . . . . .
Hazleton Biotechnologies Co Hazleton Laboratories America inc . . . . . . . . . .
Hazleton Biotechnologies Co .................... 34-32644 Hazleton Laboratories America inc . . . . . . . . . . . . .
Hazleton Biotechnologies Co . . . . . . . . . . . . . . . Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . .35-3û935
Hazleton Laboratories America .................... . 26.60096 Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 35-31936
Hazleton Laboratories America . . . . . . . . . . . . . Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 35-31937
Hazleton Laboratories America Inc . . . . . . . . . . . Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .35-31938
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .27-30051 Hazleton Laboratories America Inc . . . . . . . . . . . . . . . 35-31939
Hazleton Laboratories America inc . . . . . . . . . . . . .27-30140 Hazleton Laboratories Inc. . . . . . . . . . . . . . . . .
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 27-32466 Hazleton Raltech Inc ............................. 30-3 1854
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 28-30725 Hazleton Raltech Inc ............................. 30-31986
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 28.30726 Hazleton Raltech Inc .........................
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .28 .30727 Hazleton Raitech Inc ............................. 30-3 1988
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .28-30728 Hazleton Raitech Inc ............................. 30-3 1989
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 28-31628 Hazleton Raitech Inc ............................. 30-31990
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 28.31864 Hazleton Raitech inc ............................ -30-32347
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 28-31865 Hazleton Raitech inc ............................. 30-32348
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . .28-31866 Hine. Inc..................... . . . . . . . . . . . . 2640098
Hazleton Laboratories America h c . . . . . . . . . . . . . . . . . . . 28-31867 Hine. Inc..................... . . . . . . . . . . . . 26-60100
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 28-31868 Hine. inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26-60103
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .30-30224 Humble oil & Refining Co......................... 26-60036
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 30-31535 Humble oil & Refining Co......................... 26-60093
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 30-31996 Huntington Research Centre ...................... . 2 7 .32610
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 30-32012 Huntington Research Centre Ltd .................... 40-32425
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 3 1.30448 Huntington Research Centre Ltd .................... 40-32426
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 31-31351 Hydrospace Co. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26-60041
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 31.31352 IIT Research Institute ............................ 32-30414
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 31-31412 IIT Research institute ............................ 32-31472
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 31-31413 IIT Research Institute ............................ 32-32405
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 31-31414 IIT Research institute . . . . . . . . . . . . . . . . . . .
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 3 1.31415 IIT Research Institute ............................ 36-32643
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 31-31416 Industrial Research and Development C o p. . . . . . . . . . . . . . 36-32642
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . .31-31417 Inhalation Toxicol.Res.Inst. ........................ 30-3 1998
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-31473 Inhalation Toxicol.Res.inst., Lovelace Biomed.Env.Res.inst. . 34-31036
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-31474 inhalation Toxicol.Res.inst., Lovelace BiomedEnv.Res.inst. . 36-31430
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . .. 3 2.31708 institute of Environmental Stress .................... 32-3 1232
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-32857 International Agency for Research on Cancer . . . . . . . . . . . 31-3 1480
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-32858 International Agency for Research on Cancer . . . . . . . . . . . 32-30418
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-32859 International Research & Development C o p . . . . . . . . . . . . 30-32846
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 32-32860 International Research & Development Corp . . . . . . . . . . . .30-32855
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 33-30162 International Research & Development Corp . . . . . . . . . . . . 30-32856
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-30444 International Research & Development C o p . . . . . . . . . . . . 30-32857
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-30495 Intemationai Research & Development Corp . . . . . . . . . . . . 30.32858
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . 33-30496 International Research & Development C o p . . . . . . . . . . . . 32-30192
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33.30497 International Research & Development Corp . . . . . . . . . . . . 32-30234
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-30549 Intemational Research & Development Corp . . . . . . . . . . . . 32-32165
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 33-30592 international Research & Development Corp . . . . . . . . . . . . 32-32854
Hazleion Laboratories America Inc . . . . . . . . International Research & Development Corp ............ 33-31827
Hazleton Laboratories America inc . . . . . . . . International Research & Development Corp . . . . . . . . . . . . 33-31902
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 33-30595 Intemationai Research & Development C o p . . . . . . . . . . . .33-32724
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-30596 International Research & Development Corp . . . . . . . . . . . . 33-32864
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-31226 International Research & Development Corp . . . . . . . . . . . . 34-33173
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-32639 International Research & Development Corp . . . . . . . . . . . . 34-32600
Hazleton Laboratories America Inc . . . . . . . . . . . . . . . . . . . 33-32722 International Research & Development Corp . . . . . . . . . . . . 3.5-30936
Hazleton Laboratories America Inc . . . . . . . . . . . . International Research 8c Development Corp . . . . . . . . . . . . 35.30937
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . . 34-30634 intemational Research & Development Corp . . . . . . . . . . . . 35-31367
Hazleton Laboratories America inc . . . . . . . . . . . . . . . . . . .34-30635 international Research & Development Corp . . . . . . . . . . . .35-31368

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
i A P I PUBLxYh3Y 95 = 0732290 0549967 349

International Research & Development Corp . . . . . . . . . . . . 35-32077 Litton Bionetics inc ............................. 32-30535
international Research & Development Corp . . . . . . . . . . . . 35-32084 Litton Bionetics lnc
intox Laboratories inc . . . . . . . . . . Litton Bionetics inc
IT Air Quaiity Services inc ........................ 40-32761 Litton Bionetics inc ............................. 32-3 i30(1
J & J Marine Diving Co. inc. . . . . . . . . Litton Bionetics Inc . . . . . . . . 32-32166
Jefferson Medical College . . . . . . . . . . . Litton Bionetics Inc
Jefferson Medical College, Thomas Jefferso Litton Bionetics inc . . . . . . . . . . . . . . . 32-32168
Johns Hopkins School of Hygiene and Public Health . . . . . . 32-30419 Linon Bionetics inc
Johns Hopkins University . . . . . . . Litton Bionetics inc . . . . 32-32289
Kettering Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . 30-32847 Litton Bionetics Inc
Kettering Laboratory ............................. 32-30964 Litton Bionetics inc ............................. 32-32460
Little Aithur D Inc . . . . . . . . . . . .30-31588 Litton Bionetics inc ...... ................ 33-30929
Litton Bionetics ............................... .26-60003
Litton Bionetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26-60004
Litton Bionetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .26-60005 Litton Bionetics Inc
Litton Bionetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26-60006
Litton Bionetics ................................ 26-60007
Litton Bionetics . . . . . . . . . . . ........ . 26-60008 Litton Bionetics inc .... . . . . . . . . . . . . . . . . 33-32801
Litton Bionetics ............................... .26-60009
Litton Bionetics ................................ 26-60010
............................. 26-6001 1
............................. 26-60013
Litton Bionetics ........................... Litton Bionetics inc
Litton Bionetics ........................... Litton Bionetics inc .......................
Litton Bionetics ............................... .26-60016
Litton Bionetics ............................... .2660017
Litton Bionetics ................................ 26-60018
Litton Bionetics ............................... .26-60019 Maquette School of Medicine . . . . . . . . . . . . .
Litton Bionetics . . . . . . . . .......... ..... 26-60020 Maryland University of School of Medicine ........ 32-30417
Linon Bionetics ........ . . . . . . . . . . . . . . . . . . . .26-60021 . . . . . . . . 32-30421
Litton Bionetics ...................... . . . .26-60026
Litton Bionetics . . . . . . . . . . . . . . . . . . .
Litton Bionetics . . . . . . . . . . . . . . . . . . .
Litton Bionetics ............................... .26-60099
Litton Bionetics ................................ 26-60102
Litton Bionetics inc ............................. 27-30483
Litton Bionetics inc ............................. 27-30484
Litton Bionetics lnc ............................. 27-32127
Litton Bionetics inc ............................. 27-32128 Medical College of Wisconsin ...................... 26-60048
Litton Bionetics Inc ............................. 27-32129 Medical College of Wisconsin ...................... 26-60106
Litton Bionetics inc . . . . . . . . . . . . . . . . . . . . . . .27-32173 Medical College of Wisconsin ..................... .27-30705
Litton Bionetics inc ............................ .27-32174 Medtronic Inc., Physiol. Res. Lab
Litton Bionetics inc . . . .................... 27-32175 Meiion institute ................................ 36-33318
Litton Bionetics inc ............................. 27-32176 Melion institute . . . . . . . . . . . . . .
Liaon Bionetics Inc ............................. 27-32177 Memorial Sloan-Kettering Cancer Cen
Litton Bionetics inc ............................. 27-32179 Memorial Sloan-Kettering Cancer
Litton Bionetics Inc ............................ .28-30173 Mem. University of Newfoundlan
Litton Bionetics Inc ............................ .28-31344 Metcaif & Eddy inc. . . . . . . . . . . . . . . . . . . . . 26-31781
Litton Bionetics inc ............................. 28-31345 Microbiological Associates inc .
Litton Bionetics Inc ............................
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
.28-31346 Microbiological Associates inc ...................... 32-31710
Litton Bionetics Inc ............................. 28-31347 Microbiological Associates inc ...................... 32-3 i768
Litton Bionetics Inc ............................ .29-32357 Microbiological Associates inc ... . . . . . . . . . . . . . . . 32-31769
Litton Bionetics inc ............................ .29-32359 Microbiological Associates inc . . .
Linon Bionetics Inc ............................ .29-32360 Microbiological Associates inc ...
Litton Bionetics Inc ............................. 30-31037 Microbiological Associates inc . . .
Litton Bionetics inc ............................. 30-32003 Microbiological Associates inc . . . . . . . .
Litton Bionetics inc ............................. 31-30613 Microbiological Associates inc ...................... 32-32745
Litton Bionetics Inc ............................. 31-30614 Microbiologicai Associates inc ..................... .32-32746
Litton Bionetics Inc ............................. 31-30615 Microbiological Associates inc . . . . . . .
Litton Bionetics inc ............................. 31-30680 Microbiological Associates inc . . . . . . . . . .
Litton Bionetics inc ............................ .31-30681 Microbiologicai Associates inc . . . . . . . . . .
Litton Bionetics inc ............................. 32-30240 Microbiological Associates inc ...................... 33-30445
Litton Bionetics inc ............................. 32-30534 Microbiological Associates inc ...................... 33-30491

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L x 4 b 3 4 9 5 ie 0 7 3 2 2 9 0 0549968 285 =

Microbiological Associates Inc . . . . . . . . . . . . . . 33.30494 New York University Medical Center . . . . . . . . . . . . . . . . . 29-32358
Microbiological Associates Inc ...................... 33-30599 New York University Medical Center . . . . . . . . . . . . . . . . . 29-32681
Microbiological Associates Inc . . . . . . . . . . . . . . . . . . . . . . 33-3093 1 New York University Medical Center

I Microbiological Associates Inc . . . .


Microbiological Associates Inc . . . .
Microbiological Associates Inc . . . .
. . . . 33-30932
. . . . . . . . 33-31641
New York University Medical Center
New York University Medical Center
New York University Medical Center
I Microbiological Associates Inc ...................... 34-30858 New York University Medical Center . . . . . .
Microbiological Associates Inc . . . . . . . . . . . . . . . . 34-30859 New York University Medical Center
Microbiological Associates Inc ...................... 34-33107 New York University Medical Center . . . . . . . . . . . . . . . . . 33-31094
Microbiological Associates Inc . . . . . . . . . . . . . . . . . . . . . . 34-33108 New York University Medical Center . . . 40-30741
Microbiological Associates Inc ... . . 34-33109 New York University Medical Center . . . . . . . . . . . . . . . . . 40-30741
Microbiological Associates Inc . . . . . . . . . . . . . . . . . . . . . . 35-31365 New York University School of icine . . . . . . . . . . . . . . 33-31096
Microbiological Associates Jnc ...................... 35-32013 North C a r o h a University of . . . . . . . . . . . . . . . . . . . 26.60071
Microbiological Associates Inc . . North Carolina University of Ch Hill . . . . . . . . . . . . . .26-60024
Microbiological Associates Inc . North Carolina University of Chapel Hill . . . . . . . . . .
Microbiological Associates Inc . North Carolina University of School of Medicine . . . . .
Microbiological Associates Inc . Oak Ridge National Laboratory ..................... 30-3153 1
Microbiological Associates Inc . Oak Ridge National Laboratory 30-3 1536
Microbiological Associates Inc . . . . . . Oak Ridge National Laboratos. ..................... 30-31983

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Microbiological Associates Inc ...................... 35-32482 Oak Ridge National Laboratory . . . . . .
Microbiological Associates Inc ...................... 36-30043 Ocean Syst. inc ..................
Microbiological Associates Inc ...................... 36-30044 Oceaneering Int . . . . . . . . . . . . . . . . . .
Microbiological Associates Inc ...................... 36-30045 Ohio State University ......................... 26-60022
Microbiological Associates Inc ...................... 36-31429 Ohio State University . . . . . . . . . . . . . . . . . .
Microbiological Associates Inc ...................... 36-3 1909 Ohio State University ............................ 26-60049
Microbiological Associates Inc ...................... 36-31910
Microbiological Associates Inc ...................... 36-3191 1
Microbiological Associates Inc ...................... 36-31912
Microbiological Associates Inc ..................... . 3 6.31913
Microbiological Associates Inc ...................... 36-32641
Microbiological Associates Inc ...................... 37-30618 . . . . . . . . 41-05416
Microbiological Associates Inc ...................... 37-30619
Microbiological Associates Inc ...................... 37-30620
Microbiological Associates Inc ..................... . 37-31149
Microbiological Associates Inc ...................... 37-3 1150
Microbiological Associates Inc . . . . . . . . . 37-31152
Microbiologicai Associates Inc . . . . . . . . . 37-31487 Primate Research institute New Mexico State University . . . 34-32865
Microbiological Associates Inc ...................... 37-3 1830 Primate Research Institute New Mexico State University . . . 36-3 1364
Microbiological Associates Inc ...................... 37-32484 Procter & Gamble Co. . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-30409
Milwaukee County Med . Complex . . . . . . . . . . . . . . . . . . .27-30705 Rancho Los Amigos Hospital . . . . . 26-60029
Mobil Oil Corp. . . . . . . . . . . . . . . . . . . . . 30-31997 Rancho Los Amigos Hospital ...................... 26-60045
Mobil Oil COT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-30420 Rancho L o s Amigos Hospital . . . . . . . . . . . . . . . . . . 27.30839
Mobil Oil Corp. . . . . . . . . Rancho Los Amigos Hospital ...................... 27-30841
Mobil Oil C o p . . . . . . Rancho L o s Amigos Hospital ...................... 27-30842
MRC Exp. Embryo1. Teratol. Unit. MRC Lab . . . . . . . . . . . 34-32774 Rancho L o s Amigos Hospital Inc.................... 28-13073
National Capital Poison Cent., Georgetown Univ. Hospital . . 36-31914 Rancho L o s Amigos Medical Center Inc . . . . . . . . . . . . . . . 32-32755
National Food Laboratory Inc ..................... .40-32424 Research Triangle Institute ........................ 26-60051
Nebraska University of College of Medicine . Research Triangle Institute ........................ 39-33107
Nebraska University of Medical Center . . . . . . . . . . . . . . . . 30-3 1646 Royal Naval Physiological Laboratory ............... .26-60033
New Mexico State University ...................... 36-33220 Rutgers Medical School .......................... 33-31094
New Orleans University of ........................ 32-32651 Saint Luke’s Hospital. Milwaukee . . . . . . . . . . . . . . . . . . .26-60042
New York State Psychiatric Inst. . . . . . . . . . . . . . . . . . 32-30187 San Diego State University ........................ 39-31095
New York University . . . . . . . . . . . . . . . . . . . . . . . . . 26-60073 Shell Oil Co.........................
New York University ............................ 2640074 Shell Oil Co.........................
Shell Oil Co....................
Shell Oil Co. . . . . . . . . . . . .................... 39-31651
South. Calif Edison Co........................... . 32-32502
Southwest Research Institute .......
Springborn Institute for Bioresearch inc . . . . . . . . . . . . 32-32652
SRI International ............................... 30-32006
SRI International ............. . . . . . . . . . . . . . . 30-32007
SRI International ...................... . . 30-32008
SRI International . . . . . . . . . . . . . . . . . . . . . . . . . . 30-32077

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 b 3 4 95 = 0732290 0549969 L L L W

SRI international ............................... 32-31511 TischlerKocurek . ... .... . . 37-31299


SRI International . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.32406 ...................... . 30.32001
i SRI International ...............................
SRI international . . . . . . . . . . . . . . . . . . . .
32-32407 Toxicology Consulting Services ....................
ToxiGenics inc.
. 4 1.30735
. . . . . 30-3200s
SRI International .............................. . 33.31826 Tracor.Inc . . . . . . . 26-60119
SRI international ............................... 33-32726 TRC Environme . . . . 33-30589
SRI international . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41-30101 TRC Environmental Corp . . . . . . . . . . . . . . . . . . . . . . . . . 40-06424
Siandard Oil Co. (Indiana) . . . . . . . . . . . . . . . . . . . . . .30-32063 TRC Environmental Corp .
Standard 011 Co. (Indiana) . . . . Tuiane University
Standard Oil Co. (Indiana) . . . . . . .
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Stanford Research institute . . . . . . . . . . . . . . . . . . . . . . . . 31-30449 . . . . 31-30449


Stewart-Todd Assoc . . . . . . . . . . . . . . . . . . . . . . . . U S. Air Force Aerospace Med . Res . Lab. . . . . . . . . . . . . . .30-31534
Sun Tech inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-31982 U.S. Air Force Aerospace Med . Res. Lab. . . . . . . . . . . . . . . 30-31537
Sun Tech inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30.32000 . . . 32-30415
Systems Applications Inc. . . .................... 32-32309
Systems Applications inc. . . .................... 34-32923
Tabershaw/Cooper Associates ..................... . 26.60104 .
U S National Cancer Institute
Tabershaw/Cooper Associates ...................... 26-60120
Tabershaw/Cooper Associates Inc .................... 32-31511 U.S. Naval Medical Research institute . . . . .
Tabershaw Occupational Medicine Associates, P.A. . . . . . . . 26-60120 U.S. Naval Medical Research institute . . . . . . . . . . . . . . . . 30-31533
Tabershaw Occupational Medicine Associates PA . . . . . . . . 27-32280 U.S. Naval Medical Research institute . . . . . . . . . . . . . . . . 30-3 1534
Tegeris Laboratories ............................. 36-32640 U.S. Naval Medical Research Institute . . . . . . . . . . . . . . . . 32-30415
Tegeris Laboratories inc .......................... 32-32743 U.S. Occupational Safety & Health Administration . . . . . . . 33-31163
Tegeris Laboratories Inc .......................... 32-32747 U.S.V. Pharmaceutical C o p. . . . . . . . . 26-60054
Tegeris Laboratories Inc .......................... 32-32748 Union Carbide Corp., Bushy Run R
Tegeris Laboratories Inc .......................... 32-32751 Union Carbide Cop., Bushy Run Res . . . . . . . . . . 36-33319
Tegeris Laboratories inc .......................... 32-32752 Union Oil Co. of California ........................ 26-60063
Tegeris Laboratories inc .......................... 32-32753 Union Oil Co. of Caiifomia . . . . . . . . . . 28-70300
Tegeris Laboratories inc .......................... 33-30442 .
Universities Associated for Res & Educ. in Pathology inc . . 32-30418
Tegeris Laboratories inc .......................... 33-30443 Universities Associated for Res. & Educ. in Pathology Inc. . 32-30421
Tegeris Laboratories inc .......................... 33-30498 .
Universities Associated for Res & Educ. in Pathology Inc . . 32-30192
Tegeris Laboratories Inc .......................... 33-30499 .
University of South . calif Cancer Cent. . . . . . . . . . . . . . . . 30-91038
Tegens Laboratories Inc .......................... 33-30597 Virginia Polytechnic Institute & State University . . . . . . . . . 26-31781
Tegens Laboratories Inc .......................... 33-30598 Virginia Polytechnic institute & State University
Tegeris Laboratories inc .......................... 33-30747 Washington State University . . . . . . . . . . . . 26-60070
Tegeris Laboratones inc ...... . . . . . . . . . . . . . . . . . 33-31097 Washington University of Fisheries Research institute . . . . . 26-60001
Tegeris Laboratories inc .......................... 33-3 1098 Washington University of Fisheries Resea
Tegeris Laboratories Inc .......................... 33-31642 Washington University of Fisheries Resea
Tegens Laboratories Inc .......................... 33-31695 Washington University of School of Medi
Tegeris Laboratories inc .......................... 33-3 1696 Washington University of School of Medi
Tegens Laboratories inc .......................... 35-32430 Washington University of School of Fisheries . . . . . . . . . . . 34-30590
Tegeris Laboratories inc .......................... 37-31958 Washington University of School of Fisheries . . . . 34-32982
Texaco inc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26-60093 Washington University of Seanle .................... 30-3 1994
Texaco Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-3 1997 Washington University of Seattie . . . . . . . . . . . . . . . . . . . .40-33133
Texaco Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33-31095 Wayne State University ........................... 26-60062
Texaco inc.................................... 39-31651 Wayne State University .................
Texaco Research Center .......................... 32-3 1299 Westpath Laboratories . . . . . . . . . . . . . . . . . .
Texas A&M University ........................... 26-60002 Willis C. Picking Analfical Laboratory . . . . .
Texas A&M University .......................... . 2 6 -60002 Wisconsin University of ...................... 30-31993
Texas A&M University ........................... 2660030 W i t c o C o p ..........................
Texas A&M University ........................... 26-60030
Texas A&M University .......................... . 26.60055
Texas A&M University .......................... .26.60055
Texas A&M University .......................... .26. W 7 2
Texas A&M University .......................... . 2 6-60072
Texas A&M University .......................... -27-32178
Texas A&M University .......................... . 2 7.32178
Texas Air Control Bd ............................. 2660057
Texas University of ............................ .26 .60031
Texas University of ............................ . 2 6 -60032
Texas University of ............................ . 26.60093
Texas University of ............................. 32-30418
Thomas Jefferson University ....................... 2660054

10

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4b34 95 0732290 0547970 933

SUBJECT INDEX

ACROLEIN for Monitoring Worker Exposure to AQUATIC TOXICITY (LABORATORY


Gasoline Vapors. (32-3023 1) STUDY)
Toxicity Study Evaluation of appropriate methodologies for
measuring PNA exposures in the Birds
A Survey of Eye Imtation and Lachrymation in petroleum coking environment. (36-30038)
Relation to Air Poilution (26-60052) Introduction to Petroleum Hydrocarbons. [An Oil and Related Contaminant Effects on
Overview of the] Chemistry and Waterfowl Immune Defenses. (30-31993)
ACRYLONITRILE (REVIEW) Composition in Relation to Petroleum-
Derived Fuels and Solvents. (32-01363) Fish
Hitman exposure assessment Monitoring near refineries for airborne
chemicals on the SARA [(Superfund Effects of Oil and Chemically Dispersed Oil on

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Use of biological monitoring and biomarkers. Amendments and Reauthorization Act)] Selected Marine Bioia...A Laboratory
State-of-the-art review. (40-32427) Title III Section 313 List-4. A sampling Study. (2660050)
and analytical protocol for selected chem- Laboratory Studies on the Effects of Oil on
AIR POLLUTION icals in airborne emissions. (40-30724) Marine Organisms: An Overview (26-
Petroleum Hydrocarbon Toxicity Studies--1. 60055)
Toxicity Study Methodology. (26-60082) Oil effects on spawning behavior and
Polynuclear aromatic analyses and modified reproduction in Pacific herring (Clupea
A Survey of Eye Irritation and Lachrymation in Ames tests on base lube [lubricating] hurengus pollmi). Final Report (33-
Relation to Air Pollution (26-60052) stocks. (36-33219) 30665)
Effects of Oxidant Levels on Selected Health Quantitative analysis of benzene by selected ion The Effects of Oil on Estuarine Animais:
Characteristics of Persons in the Los monitoring/gas chromatography/mass Toxicity. Uptake and Depuration,
Angeles Basin. First Annual Repon. spectrometry. (33-32910) Respiration. (26-60030)
Volume 1. Data Collection. (26-60079) Studies on the Evaluation of Problems The effect of Prudhoe Bay crude oil on the
Associated with the Measurement of Low homing [success] of coho salmon in
ANALYTICAL CHEMISTRY Concentrations of Carboxy hemoglobin. marine waters (33-30601)
/METHODOLOGY CRC-APRAC Project No. CAPM-26-75. The toxicity of dispersed and undispersed
(27 -30700) Prudhoe Bay crude oil fractions to shrimp,
A Draft Final Report [by Battelle Columbus The Effect of Sampling Duration on the fish. and their larvae (33-32871)
Laboratories] on [its] Development pf a Concentration of Pariiculate Organics
Method for Measurement of Heterocyclic Collected on [Gelman AE] Glass-Fiber I t i vertebrares
[Polynuclear] Analytical Techniques [for Filters (28-31614)
Benzene] (26-60075) The generation and analytical methods devel- Effects of Oil and Chemically Dispersed Oil on
Aromatic Compounds [(Helero-PACs)] in opment work for the C, aromatic hydro- Selected Marine Biota...A Laboratory
Petroleum Samples (31 -31471) carbons program. Final report. (35-32077) Study. (26-60050)
API Project PS-8-GRD-ói56/Carcinogenic [API Project SPS-5-UOC(858/305)] Laboratory Studies on the Effects of Oil on
Potential of Petroleum /Comprehensive Analyses of Shale Oil Marine Organisms: An Overview (26-
Hydrocarbons ...Preparation and Analysis Products: Second Study ...Final. (28-70300) 60055)
of Fractions. (29-32615) [in] a Program for Upgrading the NO, Instru- The Effects of Oil on Estuarine Animais:
API Project PS-8-GST-(989-300) and Project mentation Employed in the 1972 Chat- Toxicity, Uptake and Depuration,
PS-8-GRD (543)/Carcinogenic Potential of tanooga NO, Exposure Study (26-60051) Respiration. (26-60030)
Petroleum Hydrocarbons...Polynuclear The Toxicity of Water-Soluble Fractions of
Aromatics in Petroleum Fractions. (29- AhTHRALIN Four Test Oils for the Polychaetous
32668) Annelids Neonrhes orenoceodenfata and
American Petroleum Institute Project Mutagenicig Study Capitella cupitota. (26-60002)
PS-22-GRD(840)/ A "Comprehensive The toxicity of dispersed and undispersed
Analysis of Petroleum Coke Products'' Characterization of the Effects of Beta- Pmdhoe Bay Cnide oil fractions to shrimp,
(28-30724) Propiolactone and Anthralin on Trans- fish, and their larvae (33-32871)
Analysis of Shale Oils and Downstream formation of BALBf3T3 Cells. (29-32681)
Products. (27-33264) AQUATIC TOXICITY (REVIEW)
Carcinogenic Potential of Peiroleum Cokes and AQUATIC TOXICITY (FIELD STUDY)
Process Producis - 1. Coking Process and Fish
Sample Characterization. (30-32002) Birds
Comprehensive Analysis of Shale Oil Products Benzene, Xylene, and Toluene in Aquatic
(Revised). (26-60063) Field studies on the reproductive effects of oil Systems: A Review (27-32296)
Evaluation of Four Air Sanipling Methods Used and emulsion on marine birds. (40-30740) Effects of Oil on Aquatic Organisms ...A

11

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLrLib3Y 75 O732290 0 5 4 9 9 7 3 8 7 T

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Review of Selected Literature (29-30299) Research Methodology pharmacodynamics. (36-3 1431)


Literature review on the effects of oil and oil Percutaneous Absorption of Benzene (30-
dispersants on fishes. (40-33133) Validation of Behavioral Studies for 31994)
Polycyclic Aromatic Hydrocarbons [(PAH)] in Determining Neurotoxicity. Final Report. Studies on the absorption of inhaled hydro-
the Aquatic Environment: Sources, Fates. (3 1-31472) carbon vapors. Final report. (34-33036)
and Biological Effects. (27-32178) Validation of Behavioral Studies for The Absorption of Petroleum Products across
Determining the Toxicity of Petroleum the Skin of Monkey and Man: Annual
Invertebrates Hydrocarbons. (30-32063) Report, Ian. 1, 1984 to Dec. (31-, 1984.
(32-32749)
Benzene, Xylene. and Toluene in Aquatic BENZENE [In-vitro measurements of the] penetration of
Systems: A Review (27-32296) benzene through human [abdominal] skin
Effects of Oil on Aquatic Organisms ...A Adyricai Chemistry IMerhodology (33-31225)
Review of Selected Literature (29-30299)
Phenolics in Aquatic Ecosystems: A Selected Quantitative analysis of benzene by selected ion Mutagenicity Study
Review of Recent ((1950-79)] Litemure monitor¡ng/gas chromatography/mass
(26-3 1781) spectrometry. (33-32910) Evaluation of Micronuclei Frequency in the
Polycyclic Aromatic Hydrocarbons [(PAH)] in Peripheral Blood of Male and Female
the Aquatic Environment: Sources, Fates, Carcinogenicity Stirdy CD-1 Mice Exposed Chemically to
and Biological Effects. (27-32178) Benzene for 90 Days. Final Report. (32-
Evidence for hematotoxicity and tumorigenesis 32855)
ARSENIC (REVIEW) in rats exposed to 100 ppm benzene (33- Inhalation Cytogenetics in Mice and Rats
31094) Exposed to Benzene. (30-319%)
Toxicity Stiidy Mutagenicity Evaluation of Benzene ...Final
Developmenial Study Report. (26-60092)
Arsenic. (26-60065) [Bio/dynamics Inc. Project No. 79-73421 /A
An Inhalaiion Teratology Study of Benzene in Dominant-Lethal Inhalation Study with
AUTOMOBILE EXHAUST Rats. (30-32012) Benzene in Rats [and Effects on Male
Inhalation Teratology Study in Rats... Benzene. Reproductive Performance]. (28-3121 1)
Mutogenicity Study Final Report. (30-30224)

Mutagenicity of Automotive Particulate Hiunan Exposure Assessment Odor and Tasre


Exhaust. The Influence of Fuel Extenders,
Additives, and Aromatic Content (30- Analysis of foods for benzene. (40-32424) A 14 day platability and stability study in
31998) Benzene levels in ambient air and breath of mice with benzene administered in
smokers and nonsmokers in urban and drinking water. (37-32486)
pristine environments (33-32727) A 14 day palatability and stability study in rats
BARIUM (REVIEW) Estimation of incremental benzene exposure with benzene administered in drinking
associated with seven bulk gasoline water. (37-32485)
Toxicity Srudy storage facilities in North Carolina. (40-
32761) Reproditcrive Eflecrs
Barium. (26-601 10) Indoor vs. outdoor ambient benzene concen-
trations: Results of the EPA Total [Bio/dynaniics Inc. Project No. 79-24251 /An
Exposure Assessment [Methodology] Inhalation Female Fertility Study with
BEHAVIORAL STUDY (TEAM) study. (35-31189) Benzene in Rats (28-31212)
Monitoring near refineries for airborne chemical [Bio/dynamics Inc. Project No. 79-73421 /A
inhalation on the SARA [(Superfund Amendments Dominant-Lethal Inhalation Study with
and Reauthorization Act of 1986)] Title Benzene in Rats [and Effects on Male
A 13 week inhalation study of potential effects III Section 313 list. Volume I...Validated Reproductive Performance]. (28-3121 i)
of commercial hexane on behavior and ambient air concentrations around three
neuromorphology in rats. (37-31 154) refineries. (36-32657) Toxicity Stiidy
An acute operant behavior study of inhaled Occupational Exposure to Benzene in the
commercial hexane in the Albino rat. (37- Petroleum and Petrochemical Industries. A Twelve-Week Inhalation Toxicity Study of
31153) (30-31525) Benzene on Seven Species of Animals.
Depressant Effects Associated with the Inha- Final Report. (27-30765)
laiion of Uncombusted Diesel Vapor (30- Meia bolismlPharniacokinetics Chronic Benzene Toxicology. Final Report.
32078) (29-32358)
The Effects of n-Odane Exposure on Schedule- Absorption of petroleum products across the Five-Day Pilot Inhalation Study in Rats and
Controlled Responding in Mice. (30- skin of monkey and man. Final report. Mice. Benzene. Final Report. (31-30448)
32080) (37-31827) Serum Immunoglobulin Levels of CD Rats and
Absorption of petroleum products across the CD-1 Mice Exposed to Benzene Vapor.
Oral skin of the monkey and miniature pig. Final Report. (30-32848)
Annual report (Mar. 15, 1979-Mar. 14, The hemotoxicity of inhaled benzene to
Behavioral Evaluaiion of Petroleum 1980). (33-31034) Sprague-Dawley rats and AKR mice at
Hydrocarbons. (30-32836) Benzene pharmokinetics and 300 ppm (33-31096)

12

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * q h 3 4 95 = 0 7 3 2 2 9 0 0549972 706 =

BENZENE (REVIEW) Developmenta i eflec is Parameters. Final Report. (30-32850)


Effects of Subchronic Fourteen-Day Exposure
Analytical CkemistSMrthodology Evaluation of benzo(a)pyrene in the in-vitro to Benzopyrene in B6C3F1 Female Mice
assay for chemical teratogenic potential: on Host Resistance. Final Report [by the
Analytical Techniques [for Benzene] (26- inhibition of proteoglycan synthesis. Final Medical College of Virginia]. (32-31512)
60075) Irport. (35-31937) Immunotoxicology of benzopyrenes in Fisher
Human embryonic palatal mesenchyme (34-4 rats. Final report. (33-31750)
Aquutic Toxicity (HEPM) cell growth inhibition assay ...S-9
m e d i a t e d a s s a y [ w i t h BUNKER C FUEL OIL
Benzene, Xylene, and Toluene in Aquatic benzo(a)pyrene] ...Final repoK (37-30619)
Systems: A Review (27-32296) Human embryonic palatal mesenchyme Aquutic Toxicity
(HEPM) cell growth inhibition assay [of
Carcinogenicity Study BaP] (36-31913) Laboratoiy Studies on the Effects of Oil on
Mouse ovarian tumor (MOT) cell attachmeni Marine Organisms: An Overview (26-
Cigarette Smoking, Benzene and Leukemia. assay with benzo(a)pyrene. (37-3 I 149) 60055)
(31-31480) Oil and Related Contaminant Effects on
Metubolismlphnrmacokinetics Waterfowl Immune Defenses. (30-31993)
Developmental Eflects The Effects of Oil on Estuarine Animais:
Absoiption of petroleum products across the Toxicity, Uptake and Depuration,
[A Review of the Published Literature on] skin of the monkey and miniature pig. Respiration. (26áoo30)
Risks to the Offspring from Parental Annual report (Mar. 15, 1979-Mar. 14, The Toxicity of Water-Soluble Fractions of
Occupational Exposures. (27-32467) 1980). (33-31034) Four Test Oils for the Polychaetous
Annelids Neunthes arenaceodeniata and
Hunton Exposure Assessnient Mutagenicity study Capitella capitam. (26-60002)

Use of biological monitoring and biomarken. Evaluation of benzo(a)pyrene in the in-vitro Chemical Countermeasures
State-of-the-art review. (40-32427) assay for chemical teratogenic potential:
inhibition of proteoglycan synthesis. Final Oil and Related Contaminant Effects on
Metabolismlf harmacokinerics report. (35-31937) Waterfowl Immune Defenses. (30-31993)
Mouse ovarian tumor (MOT) cell attachment
[A Review ofl Benzene Metabolism (26-60076) assay with benzo(a)pyrene. (37-31 149) Fate and Effects

Neurotoxicity Study Toxicity stiidy Laboratory Studies on the Effects of Oil on


Marine Organisms: An Overview (26-
Neurotoxicity of organic solvents with special Effects of Subchronic Fourteen Day Exposure 60055)
referenœ to the neurobehavioral effects: A to Benzopyrene in B6C3F1 Maie and The Effecis of Oil on Estuarine Animais:
[world] literature review (39-30623) Female Mice on Specific Immunological Toxicity, Uptake and Depuration.
Parameters. Final Report. (30-32850) Respiration. (2660030)
Toxicity Study Effects of Subchronic Fourteen-Day Exposure Uptake and Depuration of Specific Hydro-
to Benzopyrene in B6C3F1 Female Mice carbons from Oil by the Bi-valves Rangia
Benzene Toxicity. A Critical Evaluation (26- on Host Resistance. Final Report [by the cuneata and Crassostrea Virginica. (26-
60074) Medical College of Virginia]. (32-31512) 60072)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Cytologic and Cytogenetic Effects of Benzene Immunotoxicology of benzopyrenes in Fisher


[on Human Health]. (26-60121) 344 rats. Final report. (33-31750) n-BUTANE
The Molecular Site of Benzene Toxicity. (26- Twenty-four month dermal carcinogenesis/
60078) chronic toxicity screening bioassay of MetabolismlPliarmacoki>ieiics
[A Review on] Experimental Benzene refinery streams in C3HkieJ mice
Intoxication (2660077) (AP-190r). Final Report. (36-33220) Studies on the absorption of inhaled hydro-
[A Review on] Hematotoxicity in Humans (26- carbon vapors. Find report. (34-33036)
60073)
BENZO(a)PYRENE (REVIEW) Toxicity Srudy
BENZO(a)PYRENE
Human Exposure Assessment The Myocardial Toxicity [to Dogs] of Selected
Carcinogenicity study Aliphatic Hydrocarbons, [Including
Use of biological monitoring and biomarkers. Propane (P). n-Butane, Isobutane. and a
Lifetime dermal carcinogenesis bioassay of State-of-the-art review. (40-32427) Mixture of These Hydrocahns (A-46).
refinery streams in C3HMel mice and Mixtures of Isobutane with Methyl
(AP-135R). (36-3 1364) BENZO(e)PYRENE Chloroform. Trichloroethylene, Methyl
The Carcinogenicity of Raw and Spent Oil Ethyl Ketone. and Methyl Isobutyl
Shales and Retort Oils. (29-32356) Toxicig Study Ketone]. (30-32013)
Twenty-four month dennal carcinogenesis/ The absence of hydrocarbon-induced nephro-
chronic toxicity screening bioassay of Effects of Subchronic Fourteen Day Exposure pathy in rats exposed subchronically to
refinery streams in C,H/HeJ mice to Benzopyrene in B6C3F1 Male and volatile hydrocahnmixtures pertinent to
(AP-I 90r). Final Report. (36-33220) Female Mice on Specific Immunological gasoline (34-30857)

13

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * : 4 6 3 4 75 0732270 0 5 4 9 9 7 3 b 4 2

Thirteen-Week Inhalation Toxicity Study of in the CHO/HGPRT [(Chinese hamster CADMIUM (REVIEW)
CJC, Hydrocarbon Blends in Rats. Final ovaryhypoxanthine-guanine phosphon-
Report. (32-3 1472) bosyl transferase)] fonvard mutation Toxicity S t d y
suspension assay. Final Report. (35-
terl-BUTANOL (REVIEW) 30935) Cadmium: Environmental and Community
Mutagenicity test on ASTM D-3734 Type I C, Health Impact. (32-30599)
Odor and Taste in an in vitro cytogenetic assay measuring Cadmium, Zinc, and Mercury. (26-60115)
chromosomal aberration frequencies in
[A literature] review of published odor Chinese hamster ovary (CHO) cells. Final CALCIUM SULFATE
[threshold values (OTVs)] and taste report. (35-30934)
threshold values [(TïVs)] of [the 2761 Mutagenicity test on ASTM D-3734 Type I C, Toxicity Study
soluble gasoline components (33-30589) in an in vitro cytogenetic assay measuring
sister chromatid exchange frequencies in Study of Synergistic Effects of Certain Airborne
cls-2-BUTENE Chinese hamster ovary (CHO) cells. Final Systems in the Cyncnnolgus Monkey. (27-
report. (35-30933) 30704)
MeiobolismlPhnrniacokinetics Mutagenicity test on A S T M D-3734 Type i C,
in the Ames Salmonella /microsome CARBON DISULFIDE (REVIEW)
Studies on the absorption of inhaled reverse mutation assay. Final report. (35-
hydrocarbon [(HC)] vapors. Final report. 30932) Neurotoxicity Study
(34-33036)
Neurotoxicity of organic solvents with special
2-BUTYNE Neuroroxicity study reference to the neurobehaviorai effects: A
[world] literature review (39-30623)
MerobolismlPkarmacokinetics Inhalaiion neurotoxicity study in rats with C,
aromatic hydrocarbons. (35-32084) CARBON MONOXIDE
Studies on the absorption of inhaled
hydrocarbon vapors. Final report. (34- Cardiopirlnionary
33036) Reproductive effects
The Effect of Carbon Monoxide Inhalation on
CIO-CI1 ISOPARAFFIN Inhalation reproduction range-finding study in Induced Ventricular Fibrillation in the
mated rats with C, arcmatic hydrocarbons. Cynomologus Monkey. (26-60054)
Toxicity Study Final report. (35-31367)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Three generation [(F,, F,, and FJ] reproduction/ Cardiovascular


The Effect of Certain Light Hydrocarbons on fertility study in rats with C, aromatic
Kidney Function and Structure in Male hydrocarbons. (36-32642) T h e Effects of Chronic Exposure to Low Levels
Rats. (32-30408) of C a r b o n Monoxide on the
Cardiovascular System of Dogs--1.
C9 AROMATIC HYDROCARBONS Research methodology Exposure to 100 ppm Carbon Monoxide.
(26-60105)
Analytical chemisnylMethodo1ogy T h e generation and analytical methods devel-
opment work for the C, aromatic hydro- H u n m Exposure Assessment
T h e generation and analytical methods devel- carbons progrni. Final report. (35-32077)
opment work for h e C, aromatic hydro- "Nomial" Carboxyhemoglobin Levels of Blood
carbons program. Final report. (35-32077) Donors in the U.S. (26-60048)
Toxicity srirdy Carboxyhemoglobin Trend in Chicago Blood
Developmental e f e c u Donors. 1970-1974. 2430057)
Range-finding inhalation toxicity study in mice The Use of Panelists as Substimtes for Taxicab
Inhalation developmental toxicity study in mice with C, aromatic hydrocarbons. Final Drivers in Carbon Monoxide Exposure
with C, aromatic hydrocarbons. Final report. (35-30937) (26-60053)
reporl. (35-31368)
Inhalation reproduction range-finding study in Toxicity Study
mated rats with C,aromatic hydrocarbons. CADMIUM
Final report. (35-3 1367) Effects of Oxides of Nitrogen, Carbon
Range-finding inhalation toxicity study in mice Fare and Effects Monoxide and Photochemical Oxidants on
with C, aromatic hydrocarbons. Final the [Electrocardiogram] during Exercise
report. (35-30937) Bioaccumulation of polycyclic aromatic hydro- and on Cardiopulmonary Function. Final
carbons and metals in estuarine organisms. Report (APRAC Project CAPM-21-74).
Mutagenicity study (40-30741) (26-60045)
Experimental Human Exposure IO Carbon
Evaluation of C, aromatic hydrocarbons for Hiinian Exposure Assessmeni Monoxide [at Concentrations of e 1, 25,
mutagenic potential ...Bone marrow 50, 100,200. 500 and 1000 ppm for 0.5
cytogenetics test in rats. Final report. (35- The Influence of Trace Metais in Disperse to 24 Hr] (26-60001)
30936) Aerosols on the Human Body Burden of Predicting The Carboxyhemoglobin Levels
Mutagenicity test on ASTM D-3734 Type I C, Trace Metals. (27-30840) Resulting from Carbon Monoxide

14

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL84b34 95 E 0732290 0549974 5 8 9

EXPOSURS. (26-60106) Final report. (33-32725) Ceriain Petroleum Fractions. (32-30964)


Study of Synergistic Effects of Ceriain Airborne Crude petroleum and selected fractions. Skin The Evalulilion of the Carcinogenicity of
Systems in the Cynomolgus Monkey. (27- cancer bioassays. (34-30330) Certain Petroleum H y d r o c a h n Fractions
30704) Investigation of the Potential Hazards of Cancer (Revised: February 1983) with
The Effect of a Rapid 4% Cahoxyhemoglobin of the Skin Associated with the Refining Supplemental Report (Revised: March
Saturation Increase on Maximal TreadmiU of Petroleum. Final Repon. (26-60028) 1983). (30-32851)
Exercise. (26-60043) Lifetime dermal carcinogenesis/chronic toxicity Twenty-four month dermal carcinogenesis/
The Effects of Chronic Exposure to C a h n screening bioassay of [ 111 refinery chronic toxicity screening bioassay of
Monoxide (100 Ppm) on the streams in C3HMeJ mice. Twelve-month refinery streams in C3H/HeJ mice
Cardiovascular System of Monkeys. toxicity evaluation. (34-32865) (AP-190r). Final Report. (36-33220)
[CRC-APRAC Project No. CAPM-4-68]. Lifetime dermal carcinogenesis/chronic toxicity [API Project PS-81 f ï h e Evaluation of the
(27-30966) screening bioassay of refinery streams in Carcinogenicity of Certain Petroleum
[In a Two-Year] Investigation of the Effects of C3HMeJ mice. Three-month toxicity Fractions. (27-32132)
Carbon Monoxide on 1401 Humans in the evaluation report. [Vol. 1-2.1 (32-32653) [Thirty-Day] Dennal Carcinogenesis Study of
Driving Task. (26-60049) Lifetime dermal carcinogenesis/chronic toxicity Shale-Derived Hydrocarbon Mixtures
screening bioassay of refinery streams in [(350-550°F and 550-7WF)I in Mice.
CARBON MONOXIDE (REVIEW) C3HMeJ mice. Three-month toxicity (32-30626)
evaluation report. Final report. (33-32010)
Toxicity Siudy Lifetime dennal carcinogenesis/chronic toxicity
screening bioassay of refinery streams in Epidemiology Study
Air Quality Standards for Carbon Monoxide. C3H/HeJ mice. Twelve-month toxicity
(26-60062) evaluation report. Final report. [Vol. 1-31. A case-control study of kidney cancer among
(33-3 1451) petroleum refinery workers. Final report.
Lifetime dermal carcinogenesis bioassay of (37-3 1336)
CARBON TETRACHLORIDE (REVIEW) shale oil-derived streams in C3H/HeJ Kidney Cancer Epidemiology in Petroleum-
niice. Final interim report. (33-32009) Related Studies. (32-30420)
Carcinogenicity study Lifetime dermal carcinogenesis bioassay of
refinery streams in C3H/HeJ mice Inlulaiion
A Brief Review of [Published Data on] the (AP-135R). (36-3 1364)
Toxicity and Carcinogenicity of Select Short-term dermal tumorigenesis study of A Chronic Inhalation Study with Unleaded
Chlorinated Hydrocarbons. (32-30417) selected petroleum hydrocarbon Gasoline Vapor. (32-32227)
[processing fractions] in male CD-1 A Final Report [on a] 24 Month Inhalation
Toxicity Study mice. Initiation and promotion Toxicity Study of Raw and Spent Shale
phases [of dermal tumorigenesis]. Dusts in Rats and Monkeys (27-32466)
A Brief Review of [Published Daia on] the (36-32643) An inhalation oncogenicity study of commercial
Toxicity and Carcinogenicity of Select Skin Carcinogenic Potential of Petroleum hexane in rats and mice--1. Rais. Final
Chlorinated Hydrocarbons. (32-30417) Hydrocarbons-l. Separation and Charac- report. (41-33231)
terization of Fractions for Bioassay. (30- An inhalation oncogenicity study of commercial
CARBOXYHEMOGLOBIN 3 1982) hexane in rats and mice--2. Mice. Final
Skin Carcinogenic Potential of Petroleum report. (41 -33232)
Carboxyhemoglobin Trend in St. Louis Blood Hydmarbons--2. The Carcinogenesis of Chronic Gasoline Toxicity [Tesis on Laboratory
Donors, 1971-1975. CRC-APRAC Project Crude Oil. Distillate Fractions and Animals]. (30-31991)
NO. CAPM-8-68. (27-30705) Chemical Class Subfractions. (30-32000) Evidence for hematotoxicity and tumorigenesis
Final Report of the Study of the Relationship Skin Tumorigenesis in Mice by Petroleum in rats exposed to 100 ppm benzene (33-
between Carboxyhemoglobin on Asphalts and Coal Tar Pitches of Known 31094)
Admission to the Subsequent Hospital Polynuclear Aromatic Hydrocarbon Final Repon: The Cancer Incidence among
Course of Patients Admitted to the Content. (2640122) Members of a Heavy Constnidion
Myocardial Infarction Research Unit at the Statistical Analyses of Crude Oil and Shale Oil Equipment Operators Union with Potential
Johns Hopkins Hospital. [CRC-APRAC Carcinogenic Test Data (30-32001) Exposure to Diesel Exhaust Emissions
Project No. CAPM-13-69]. (27-30965) Studies on the Toxicity of Petroleum Waxes. (30-31645)
Studies on the Evaluation of Problems (26-60080) Hydrocarbon Toxicity: Acute, Subchronic and
Associated with the Measurement of Low The Carcinogenic Potential of Key Petroleum Chronic Effects in Relation to Unleaded
Concentrations of Carboxyhemoglobin. Products (30-31646) Gasoline Exposure of Rodents, with
CRC-APRAC Project No. CAPM-26-75. The carcinogenic potential of petroleum cokes Comments on the Significance to Human
(27-30700) and process products - 2. Bioassay. (30- Health. (32-30192)
3201 1) Neoplastic Renal Effects of [Inhaled] Unleaded
CARCINOGENICITY STUDY The Carcinogenicity of New and Used Gasoline in Fischer (34-4 Rats. (32-
Lubricants. (30-32847) 30413)
Dermal The Carcinogenicity of Raw and Spent Oil
Shales and Retort Oils. (29-32356) Occtipaiional Health
Carcinogenic Potential of Petroleum Coke and The Determination of the Carcinogenicity of
Process Products. (30-31598) [Shale] Retoti Oils and Downstream A case-control study of kidney cancer among
Characterization of the carcinogenic nature of Products. (30-32849) petroleum refinery workers. Final report.
selected low boiling [petroleum] fractions. The Evaluation of the Carcinogenicity of (37-31336)

15
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 9 5 W 0 7 3 2 2 9 0 0549975 415

Kidney Cancer Epidemiology in Petroleum- CARDIOVASCULAR mouse embryo cells. API 81-15,
Related Studies. (32-30420) catalytically cracked clarified oil (CAS
Inlialution 6474162-4). Final report]. (33-32638)
Oral Mouse ovarian tumor (MOT) cell attachment
The Effects of Chronic Exposure to Low Levels assay with API 81-15: Catalytic cracked
Studies on the Toxicity of Petroleum Waxes. of Carbon Monoxide on the Cardio- clarified oil. Final report. (35-32480)
(26-60060) vascular System of Dogs--1. Exposure to Mutagenicity Evaluation Studies [of Catalytical-
100 ppm C a h n Monoxide. (26-60105) ly Cracked Clarified Oil (API Sample
#81-15)] in the Rat Bone Marrow Cytoge-
CATALYTIC CRACKED CLARIFIED O I L netic Assay and in the Mouse Lymphoma
Studies on the Toxicity of Petroleum Waxes. Forward Mutation Assay. Final Repon.
(26-60080) Carcinogenicify srrtdy (32-30534)
Sister Chromatid Exchange Assay in Chinese
Research Meïhàology Lifetime dermal carcinogenesis/chronic toxicity Hamster Ovary (CHO) Cells. API 81-15,
screening bioassay of refinery streams in Catalytically Cracked, Clarified Oil (CAS
Statistical Evaluations in the Carcinogenesis C3HíHeJ mice. Twelve-month toxicity 64741-62-4). Final Report. (32-32750)
Bioassay of Petroleum Hydrocarbon. (30- evaluation report. Final report. [Vol. 1-31.
31983 (33-31451) Toxicity sruày
The Occurrence and Natural History of Lifetime dermal carcinogenesis bioassay of
Experimental Skin Tumors. (30-31999 refinery streams in C3H/HeJ mice A 28-Day Dermal Toxicity Study of API [Cata-
(AP-135R). (36-31364) lytic Cracked Clarified Oil] Sample 81-15
Review Short-tem dermal tumorigenesis study of in the Rabbit (30-32854)
selected pet roleu rn hydrocarbon Acute Toxicity Studies of Catalytically Cracked
A Brief Review of [Published Daia on] the [processing fractions] in male CD-1 Clarified Oil. APl Sample 81-15. (30-
Toxicity and Carcinogenicity of Select mice ...Initiation and promotion phases [of 3 i 854)
Chlorinated Hydrocarbons. (32-30417) dermal tumorigenesis]. (36-32643) Dermal Sensitization Study in Guinea Pigs.
Carcinogenic Potential of Petroleum Closed Patch Technique. Catalytic
Hydrocarbons. A Critical Review of the Developmental effects Cracked Clarified Oil. API Sample 81-15.
Literature (27-30915) (3 1-31417)
Cigarette Smoking, Benzene and Leukemia. Evaluation of API 81-15 (catalytic cracked cla- Four-week dermal range-finding toxicity study
(3 1-31480) rified oil) in the in-vitro assay for chem- in rats: API 81-15, catalytically cracked
Gasoline: Insights into the etiology of the ical teratogenic potential: Inhibition of clarified oil (CAS 64741-62-4). Final
development of hepatocellular carcinoma proteoglycan synthesis. Final report. (35- report. (33-30442)
in the mouse. (41 -30735) 31938) Lifetime dermal carcinogenes¡ dchronic toxicity
Hydrocahon Toxicity: Acute. Subchronic and Human embryonic palatal mesenchyme screening bioassay of refinery streams in
Chronic Effects in Relation IO Unleaded (HEPM) cell growth inhibition assay [of C3HRleJ mice. Twelve-month toxicity
Gasoline Exposure of Rodents, with API-61-19 (catalytic cracked clarified evaluation report. Final report. [Vol. 1-31.
Comments on the Significance to Human oil)] ...S-9 mediated assay (36-31910) (33-31451)
Health. (32-30192) The human embryonic palatal mesenchyme Lifetime Demal Carcinogenesis/Chronic
Investigation of the Potential Hazards of Cancer (HEPM) cell growth inhibition assay [of Toxicity Screening Bioassay of Refinery
of the Skin Associated with the Refining API-81-15 (catalyticcracked clarified oil)] Streams in C3HRleJ Mice. Three-Month
of Petroleum. Final Report. (26-60028) (36-31909) Toxicity Evaluation Report. [Vol. 1-21,
Polycyclic Aromatic Hydrocarbons [(PAHs)] : (32-32653)
A Rwiew (28-30174) Mirragenici fy study Thirteen Week Dermal Toxicity Study of a
Toxicological Characteristics of Refinery Petroleum-Derived Hydrocarbon in Rats:
Streams Used To Manufacture Lubricating An Evaluation of the Potential of RO-i, 81-15, (API 81-15) Catalytically Cracked
Oils. (31 -02438) and PS8-76D5-SAT To Induce Unsched- Clarified Oil (CAS 64741-62-4). Final
[A Review ofl the Epidemiology of Renal uled DNA Synthesis in Primary Rat Report. (32-32743)
Carcinoma in Humans with a Note on the Hepatocyte Cultures (32-32407)
Effect of Exposure to Gasoline (32-30418) An Evaluation of the Potential of RO-1, 81-15, CATALYTIC GAS OIL (REVIEW)
and PS8-76D5-SAT To Induce Unsched-
uled DNA Synthesis in the In Vivo-In CurcinogenicifyStudy
CARDIOPULMONARY Vitro Hepatocyte DNA Repair Assay (32-
32406) Investigation of the Potential Hazards of Cancer
Initalaïion Evaluation of API 81-15 (catalytic cracked of the Skin Associated with the Refining
clarified oil) in the in-vitro assay for of Petroleum. Final Report. (26-60028)
The Effect of Carbon Monoxide Inhalation on chemical teratogenic potential: Inhibition
Induced Ventricular Fibrillation in the of proteoglycan synthesis. Final report. CATALYTIC REFORMED NAPHTHA
Cynomologus Monkey. (26-60054) (35-3 1938)
Effects of Sulfate Aerosols upon In Vivo Sister Chromatid Exchange Assay, API Miitugeniciry Sïiidy
Cardiopulmonary Function in Squirrel 81-15, Catalyticaüy Cracked, Clarified Oil
Monkeys. Report of Second Year’s Work (CAS 64741424). Final Report. (32- Mutagenicity Evaluation of 83-05 in the Rat
under APRAC Project CAPM-20-74. (26- 32754) Bone M a m w Cytogenetic Assay. Final
W 9 ) Morphological transformation of BALB/3T3 Report. (32-32289)

16
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 95 O732290 0 5 4 9 9 7 6 3 5 1

Mutagenicity Evaluation of Catalytic Reformed Petroleum in the freshwater environment, An CRUDE O I L


Naphtha, API #83-05, in the Mouse annotated bibliography [covering]
Lymphoma Forward Mutation Assay. 1946- 1983. (39-33456) AM lyricaI ChenrisirylMethoabiogy
Final Report. (32-32459)
API Project PS-8-GRD-6156/Carcinogenic
Toxicity Study CHLORINATED DIOXINS (REVIEW) Potential of Petroleum Hydrocarbons.
Preparation and Analysis of Fractions.
Acute Inhalation Toxicity Evaluation of a Toxicity Study (29-32615)
Petroleum-Derived Hydrocarbon in API Project PS-8-GST-(989-300) and Project
Rats...Full-Range Catalytic Reformed Dioxins and furans...A primer: What h e y are PS-8-GRD (543)/Carcinogenic Potential of
Naphtha. API Sample 83-05. (31-30681) and how to measure them. (37-31299) Petroleum Hydrocarbons. Polynuclear
Dermal sensitization study in guinea pigs [by Aromatics in Petroleum Fractions. (29-
Hazleton Laboratones America Inc.] : API 32668)
83-05 full-range catalytically cracked CHLORINATED FURANS (REVIEW)
reformed naphtha (CAS 68955-35-1). Aquaiic toxicity
Final report. (33-30497) Toxicity Study
[A Tegeris Laboratories Inc.] (28-day dermal Effects of Oil and Chemically Dispersed Oil on
toxicity study in the rabbit. API 83-05 full Dioxins and furans...A primer: What they are Selected Marine Biota...A Laboratory
range catalytically reformed naphtha (CAS and how to measure them. (37-31299) Study. (26-60050)
68955-35-1). [This] final report (33- Field studies on the reproductive effects of oil
30598) and emulsion on marine birds. (40-30740)
[Hazleton Laboratories America Inc.'s] Acute CHLOROFORM (REVIEW) Laboratory Studies on the Effects of Oil on
Oral Toxicity Study in Rats. Acute Marine Organisms: An Overview (26-
Dermal Toxicity Study in Rabbits. Carcinogenicity Siudy 60055)
Primary Dermal Irritation Study in Oil and Related Contaminani Effects on
Rabbits, and Primary Eye Irritation Study A Brief Review of [Published Data on] the Waterfowl Immune Defenses. (30-31993)
in Rabbits of API 83-05 Full Range Toxicity and Carcinogenicity of Select Oil effects on spawning behavior and reproduc-
Catalytically Reformed Naphtha. (32- Chlorinated Hydrocarbons. (32-30417) tion in Pacific herring (Clupa harengus
3 1474) paliasi). Final Report (33-30665)
Neurotoxicity Study The effect of Prudhoe Bay crude oil on the
CHEMICAL COUNTERMEASURES homing [success] of coho salmon in
(FIELD STUDY) Neurophysiological and Psychological Disorders marine waters (33-30601)
and Occupational Exposure to Organic The Effects of Oil on Estuarine Animals:
Sublethal Solvents. (31-32980) Toxicity. Uptake and Depuration,
Respiration. (26-60030)
Field studies on the reproductive effects of oil Toxicity Study The Toxicity of Water-Soluble Fractions of
and emulsion on marine birds. (40-30740) Four Test Oils for the Polydiaetous
The Role of Chemical Dispersants in Oil Spill A Brief Review of [Published Data on] the Annelids Neanikes arenaceodeniara and
Control. (33-32622) Toxicity and Carcinogenicity of Select Capitella capiraia. (26-60002)
Chlorinated Hydrocarbons. (32-30417)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Carcinogenicity study
CHEMICAL COUNTERMEASURES
(LABORATORY STUDY) CHROMIUM (REVIEW) Crude petroleum and selected fractions. Skin
cancer bioassays. (34-30330)
Subleihal Toxicity Study Skin Carcinogenic Poieniial of Petroleum
Hydrocarbons--2. ?he Carcinogenesis of
Effects of crude oil and chemically dispersed Chromium. (26-60113) Crude Oil. Distillate Fractions and
oil on chemoreception and hmiing in Chemical Class Subfractions. (30-32000)
Pacific salmon. (34-32982) Skin Carcinogenic Potential of Petroleum
Influence of crude oil and dispersant on the COAL TAR PtTCH Hydrocarbons-i. Separation and Charac-
ability of coho salmon to differentiate terization of Fractions for Bioassay. (30-
home water from non-honie water. (34- Carcinogeriiciry S ~ i d y 3 1982)
30590) Statistical Analyses of Crude Oil and Shale Oil
Oil and related Contaminant Effects on Skin Tumorigenesis in Mice by Petroleum Carcinogenic Tesi Data. (30-32001)
Waterfowl Immune Defenses. (30-31993) Asphalts and Coal Tar Pitches of Known The Evaluation of the Carcinogenicity of
Polynuclear Aromatic Hydrocarbon Certain Petroleum Hydrocarbon Fractions
Content. (26-60122) (Revised: February 1983) with
CHEMICAL COUNTERMEASURES Supplemental Report (Revised: March
(REVIEW) 1983). (30-32851)
COPPER (REVIEW) [API Project PS-81 m e Evaluation of the
Subletlia1 Carcinogenicity of Certain Petroleum
Toxicity Study Fractions. (27-32132)
Literature review on the effects of oil and oil [Thirty-Day] Dermal Carcinogenesis Study of
dispersants on fishes. (40-33133) Copper. (26-60068) Shale-Derived Hydrocarbon Mixtures

17

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L U 4 6 3 4 95 m 0 7 3 2 2 9 0 0 5 4 9 9 7 7 298 m

[(350-550 O F and 550-700 OF)] in Mice. Aqiiaric Toxicity Morphological transfomation of BALB/3T3
(32-30626) mouse embryo cells. API PS-8-76CZ.
The toxicity of dispersed and undispersed Final report. (34-30859)
Chemical countermeasures Prudhoe Bay crude oil fractions to shrimp, Morphological transformation of BALBnT3
fish, and their larvae (33-32871) mouse embryo cells. API PS-8-76D5
Effeds of crude oil and chemically dispersed ARO. Final report. (34-30858)
oil on chemoreception and homing in Carcinogenicity Srudy Mutagenicity Evaluation of Six Petroleum
Pacific salmon. (34-32982) Substances in an In-Vivo/ln-Vitro Urine
Field studies on the reproductive effects of oil Characterization of the carcinogenic nature of Assay. (30-31037)
and emulsion on manne birds. (40-30740) selected low boiling [petroleum] fractions. Salmonella/mammalian-microsome plate
Influence of crude oil and dispersant on the abi- Final report. (33-3272s) incorporation mutagenicity assay (Ames
lity of coho salmon to differentiate home Crude petroleum and selected fractions. Skin test). Final report. (33-30599)
water from non-home water. (34-30590) cancer bioassays. (34-30330) Sister Chromatid Exchange Assay in Chinese
Oil and Related Contaminant Effects on Skin Carcinogenic Potential of Petroleum Hamster Ovary (CHO) Celis [Exposed to]
Waterfowl Immune Defenses. (30-31993) Hydrocarbons--2. The Carcinogenesis of PS-8-DS-Saturates. Final Report. (32-
The Role of Chemical Dispersants in Oil Spill Crude Oil, Distillate Fractions and 32731)
Control. (33-32622) Chemical Class Subfractions. (30-32000) Sister chromatid exchange assay in Chinese
The Evaluation of the Carcinogenicity of hamster ovary (CHO) cells. API
Fate and Eflects Certain Petroleum Fractions. (32-30964) PS-8-76D5 aromatics. Final repon [by
The Evaluation of the Carcinogenicity of Microbiological Associates Inc.]. (33-
Uptake and Depuration of Specific Hydro- Cenain Petroleum Hydrocarbon Fractions 30931)
c a h s from Oil by the Bi-valves Rangia (Revised: February 1983) with
cuneata and Crassostrea virginica. (26- Supplemental Report (Revised: March Research Metliodology
1983). (30-32851)
[API Project PS-81 /Ihe Evaluation of the Lack of Concordance of the Salmonella/ Micro-
Meia bolismlPharmacokinerics Carcinogenicity of Certain Petroleum some Assay with the Mouse Dermal Car-
Fractions. (27-32132) cinogenesis Bioassay for Complex Petro-
Absorption of petroleum products across the leum Hydrocarbon Mixtures. (32-31299)
skin of the monkey and miniature pig. Mitiagenici@ Study
Annual report (Mar. 15, 1979-Mar. 14, CRUDE OIL, HIGH-NITROGEN
1980). (33-31034) Adapting the Ames Salmonella Assay to
The Induction of Xenobiotic Metabolism in Complex Hydrocarbon Mixtures. Final Carcinogenicity srudy
Rats cm Exposure to Hydrocarbon-Based Report. (32-32856)
Oils. (30-31995) An Evaluation of the Potential of RO-i. 81-15. [Thirty-Day] Dermal Carcinogenesis Study of
and PS8-76D5-SAT To Induce Shale-Derived Hydrocarbon Mixtures
Research Merliodology Unscheduled DNA Synthesis in Primary [(350-550 "F and 550-700 OF)] in Mice.
Rat Hepatocyte Cultures (32-32407) (32-30626)
Lack of Concordance of the Salmonella/ Micro- An Evaluation of the Potential of RO-1.81-15,
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

some Assay with the Mouse Dermal Car- and PS8-76DS-SAT T o Induce Toxicity Stiuiy
cinogenesis Bioassay for Complex Petro- Unscheduled DNA Synthesis in the In
leum Hydrocarbon Mixtures. (32-31299) Vivo-In Vitro Hepatocyte DNA Repair Twenty-Eight Day Subchronic Dermal Toxicity
Assay (32-32406) S t u d y in R a t s : A P I - H N C - I
An in-vivo sister chromatid exchange assay of (High-Nitrogen, [0.77%], Cnide Oil);
CRUDE OIL (REVIEW) APl PS-8-76DS-ARO, aromatic APl-SFP-IO5 (0.05% N, Hydrotreated
subtraction of 700-1070 OF boiling range Shale Oil); API-SFP-119 (0.19% N.
Aquatic Toxicity fraction of a crude oil. (35-32013) Hydrotreated Shale Oil); APl-SFP-206
Evaluation of Techniques for Mutagenicity (0.06% N. Hydrotreated Shale Oil);
Petroleum in the freshwater environment ...An Screening of Petroleum Hydrocarbons. API-SFR-1 ([1.6% NI, Raw Shale Oil);
annotated bibliography [covering] (30-3 1588) API-SFR-2 ([2.1% NI. Raw Shale Oil).
194-1983. (39-33456) Evaluation of the potential of PS-8-76D5-ARO (32-32652)
to induce unscheduled DNA synthesis in
CRUDE OIL FRACTION the in-vivo/in-vitro hepatocyte DNA repair CYCLOHEXANE
assay. Final report [by SRI International].
Analytical ChemistSMerhodology (33-3 1826) Miiiagenicip study
Evaluation of the potential of PS-8-76D5-ARO
API Project PS-8-GRD-6156/Carcinogenic to induce unscheduled DNA synthesis in Mutagenicity Evaluation of Certified
Potential of Petroleum Hydrocarbons. primary rat hepatocyte cultures. Final Cyclohexane. Final Report. (29-32357)
Preparation and Analysis of Fractions. report [by SRI Intemational]. (33-31751)
(29-32615) Final Report: Testing of API Petroleum CYCLOPHOSPHAMIDE
API Project PS-S-GST-(989-300) and Project Fractions for Genotoxicity in C3HIlOTiR
PS-8-GRD (543)/Carcinogenic Potential of Cells. (30-31038) Research methodology
Petroleum Hydrocarbons. Polynuclear in-vivo sister chromatid exchange assay. API
Aromatics in Petroleum Fractions. (29- PS8-76D5 saturates. Final repon. (33- Dealing with uncertainties in a biologically
32668) 30932) based risk assessment model of

18

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 9 5 I0 7 3 2 2 9 0 0 5 4 9 9 7 8 1 2 4

cyclophosphamide-induced leukemo- In vitro hexane test rule. 40 CFR


genesis. (41-32131) Two-Ceneraiion reproduction
Human embryonic palatal mesenchyme inhaled commercial hexane in
Risk assessment (HEPM) cell growth inhibition assay [with (Sprague-Dawley) rats. (38-312
...
toluene] Final report. (37-3061 8) Inhalation developmental toxicity stul
Dealing with uncertainties in a biologically Human embryonic palatal mesenchyme with C, aromatic hydrocarbt
based risk assessment model of (HEPM) cell growth inhibition assay ...S-9 repon. (35-31368)
cyclophosphamide-induced leukemo- mediated assay [wilh benzo(a)pyrene Inhalation reproduction range-findin
genesis. (41 -3213 i) (BaP)] ...Final report. (37-30619) mated rats with C, aromatic hyd
Human embryonic palatal mesenchyme Final report. (35-3 1367)
DECALIN (HEPM) cell growth inhibition assay...S-9 Inhalation Teratology of Jet Fuel A.
mediated assay [with toluene] ...Final and Petroleum Naphtha in 1
Toxicity Study report. (37-30620) 32003)
Human embryonic palatal mesenchyme Inhalation Teratology Study in Rats.
Pathologic Findings in Laboratory Animals (HEPM) cell growth inhibition assay [of Final Repoli. (30-30224)
Exposed to Hydrocarbon Fuels of Military BaP] (36-3 1913) Inhalatiofleratology Study in Rats.
Interest. (32-30416) Human embryonic palatal mesenchyme Final Report. (27-30483)
The Pathogenesis of the Nephrotoxicity of (HEPM) cell growth inhibition assay [of Inhalatiofleratology Study in Rats.
Volatile Hydrocarbons in the Male Rat. API-8ó-02 (a dark viscous petroleum Naphtha. Fmal Report. (27-304
(32-30409) liquid)] ...S-9 mediated assay (36-31912) Inhalatiofleratology Study in Rats..
Human embryonic palatal mesenchyme Final Repon. (27-32173)
DECANE (HEPM) cell growth inhibition assay [of Parental and Fetal Reproduction
API-81-15 (catalytic cracked clarified Toxicity Study, in Rats, wi
Toxicity Strdy oil)]...S-9 mediated assay (36-31910) Xylenes. Final Report. [Vol. I
Human embryonic palatal mesenchyme 31481)
Final Report. A four-week oral nephrotoxicity (HEPM) cell growth inhibition assay [of Range-finding inhalation toxicity stui
screening study in male i344 rats (33- API-86-02 (a dark viscous petroleum with C, aromatic hydrocarbc
3 1097) liquid)] (36-31911) report. (35-30937)
The human embryonic palatal mesenchyme Teratology Studies in Rats. Raw S
(HEPM) œil growth inhibition assay [of Final Repon. (26-60007)
DEVELOPMENTAL EFFECTS API-81-15 (catalytic cracked clarified oil)] Teratology study in Rats. Stoddan
(36-31909) Final Report. (26-60026)
HEPM cell growth inhibition assay) Teratology Study in Rats. High
Inhalation Solvent. Final Report. (27-321'
Human embryonic palatal mesenchyme Teratology Study in Rats. Rubber Sol
(HEPM) cellgrowth inhibition assay [with A preliminary study of the effect of toluene on Repon. (26-60015)
toluene] ...Final report. (37-30618) pregnancy [and in utero development] of Teratology Study in Rats. Toluc
Human embryonic palatal mesenchyme the rat. (Inhalation exposure). (40-32425) Report. (26-60019)
(HEPM) cell growth inhibition assay ...S-9 A single-generation inhalation reproduction/ Teratology Study in Rats. Unleaded
mediated assay [with benzo(a)pyrene fertility study on a commercial hexane Final Report. (26-60014)
(Bal')] ...Final report. (37-30619) (33-32864) Teratology Study in Rats. Xylene. Fii
Human embryonic palatal mesenchyme A Single-Generation Inhalation Reproduction/ (26-60013)
(HEPM) cell growth inhibition assay ...S-9 Fenility Study in Rais with Methyl t-Butyl Teratology Study in Rats. Retorted S
mediated assay [with toluene] ...Final Ether (MTBE). (32-30239) Final Repon. (26-60008)
report. (37-30620) A teratology evaluation of methyl tertiary butyl Teratology Study in Rats. Shale Oil
Human embryonic palatal mesenchyme ether in rats and mice (33-31095) Report [on LBl Project No. 2(
(HEPM) cell growth inhibition assay [of An Inhalation Teratology Study of Benzene in (27-32127)
BaP] (36-31913) Rats. (30-32012) Teratology Study in Rats. n-Hex;
Human embryonic palatal mesenchyme An Inhalation Teratology Study in Rats with Report. (27-32177)
(HEPM) cell growth inhibition assay [of Methyl t-Butyl Ether (MTBE). (32-30236) Teratology Study in Rats. Shale Oil
API-86-02 (a dark viscous petroleum An Inhalation Teratology Study in Mice with Report [on LBI Project 20726-
liquid)]...S-9 mediated assay (36-31912) Methyl i-Butyl Ether (MTBE). (32-30237) 32128)
Human embryonic palatal mesenchyme Developmental toxicity study of commercial Teratology Study in Rats. Kerosi
(HEPM) c e U growth inhibition assay [of hexane vapor in CD(TM) (Sprague- Repon. (27-32175)
API-81-15 (catalytic cracked clarified Dawley) rats. (36-33319) Teratology Study in Rats. Shale Oil
oii)]..,S-9 mediated assay (36-3 1910) Developmental toxicity study of commercial Report [on LBI Project No. 2(
Human embryonic palatal mesenchyme hexane vapor in CD(TM)-I mice. (36- (27-32 129)
(HEPM) cell growth inhibition assay [of 33318) Teratology Study in Rats. Diesel I
API-86-02 (a dark viscous petroleum Final Report, April 17. 1991. Commercial Repon. (27-32174)
liquid)] (36-3191 i) hexane test rule, 40 CFR 799.2155. Toluene...The effect on pregnancy [a
The human embryonic palatal mesenchyme Two-generation reproduction study of development] of the rat.
(HEPM) cell growth inhibition assay [of inhaled commercial hexane in CD(TM) exposure). (40-32426)
API-81-15 (catalytic cracked clarified oil)] (Sprague-Dawley) rats. (38-31216) Two-Generation Inhalation Rep
(36-31909) Final Report, April 17. 1991. Commercial Fenility Study on a Petroleum.

19
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLX4634 95 0 7 3 2 2 9 0 0549979 O b 0 W

Hydrocarbon, Toluene [Vol. i]. (32- a Cohort of [Heavy Equipment Operator] DIESEL FUEL (REVIEW)
32854) Union Members, Potentially Exposed to
Diesel Exhaust Emissions (30-31639) Toxicity Stidy
M o u e embryo limb bud Final Report: The Cancer Incidence among
Members of a Heavy Construction A Review of the Human Kidney Effects of
Evaluation of API 86-02 (solvent refined coal Equipment Operators Union with Potential Hydrocarbon Exposure (32-30410)
distillate) in the in-vitro assay for Exposure to Diesel Exhaust Emissions
chemical teratogenic potential: Inhibition (30-31645)
of proteoglycan synthesis. Final report. Final Report: The Mortality among Members of DIESEL FUEL MARINE
(35-3 1936) a Heavy Construction Equipment
Evaluation of API 81-15 (catalytic cracked Operators Union with Potential Exposure Toxicity Study
clarified oil) in the in-vitro assay for to Diesel Exhaust Emissions (30-31644)
chemical teratogenic potential: Inhibition Pathologic Findings in Laboratoiy Animals
of proteoglycan synthesis. Final report. DIESEL FUEL Exposed to Hydrocarbon Fuels of Military
(35-31938) interest. (32-30416)
Evaluation of benzo(a)pyrene in the in-vitro Behavioral Study Toxicology of Mixed Distillate and
assay for chemical teratogenic potential: High-Energy Synthetic Fuels. (32-30415)
Inhibition of proteoglycan synthesis. Final Depressant Effects Associated with the
report. (35-31937) Inhalation of Uncombusted Diesel Vapor
Evaluation of toluene in the in-vitro assay for (30-32078) 23-DIMETHYLBUTANE
chemical teratogenic potential: Inhibition
of proteoglycan synthesis. Final report. Carcinogenicity S r d y Mutagenicity S r d y
(35-31939)
The Carcinogenic Potential of Key Petroleum The L5178Y TK+/-mouse lymphoma muta-
Mouse ovarwn tiimor cell attachntenr assay Products (30-3 i 646) genesis assay with 2,3dimethylbutane.
Final report. (34-33109)
Mouse ovarian tumor (MOT) cell attachment Developmenral Stirdy
assay with API 81-15: Catalyiic cracked Toxicity Srirdy
clarified oil. Final report. (32-32480) Teratology Study in Rats. Diesel Fuel. Final
Mouse ovarian tumor (MOT) cell attachment Report. (27-32174) Four-Week Oral Nephrotoxicity Screening
assay with API 86-02: Solvent refined Study in Male F344 Rats [by Borriston
coal distillate. Final report. (32-32481) Epideniiology Srirdy Laboratories Inc.]. Final Report. (32-
Mouse ovarian tumor (MOT) cell attachment 30966)

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
assay with benzo(a)pyrene. (37-31149) A Moilality Study of Petroleum Refinery
Mouse ovarian tumor (MOT) cell attachment Workers. (26410120) 2J-DIMETHY LDECANE
assay with toluene. (37-31 150)
Miiragenicity Srirdy Toxicity Siirdy
Research Methadology
Mutagenicity Evaluation of Diesel Fuel. (26- Final Report. A four-week orai nephrotoxicity
Teratogenicity testing in vitro: Status of 60102) screening study in male F344 rats (33-
validation studies. (34-32774) Mutagenicity Evaluation of Petroleum 3 1097)
Hydmarbons. (30-31997)
Review [Litton Bionetics Inc. Project No. 21141-041 2.3-DIMETHYLOCTANE
/Mutagenicity Evaluation of Diesel Fuel in
[A Review of the Published Literature on] the Mouse Dominant Lethal Assay. Final Toxicity Sr1rd.y
Risks to the Offspring from Parental Report. (28-31346)
Occupational Exposures. (27-32467) Final Report. A four-week oral nephrotoxicity
Reprodirctive EJfecrs screening study in male F344 rats (33-
DIESEL EXHAUST EMISSIONS 31097)
[Litton Bionetics Inc. Project No. 21141-041
Carcinogenicity Sriidy /Mutagenicity Evaluation of Diesel Fuel in 23-DIMITHY LPENTANE
the Mouse Dominant Lethal Assay. Final
Fmai Report: The Cancer Incidence among Report. (28-31346) MerabolismlPharniacokinerics
Members of a Heavy Construction
Equipment Operators Union with Potential Toxicity Srirdy Studies on the absorption of inhaled
Exposure to Diesel Exhaust Emissions hydrocarbon vapors. Final repon. (34-
(30-31645) The Acute Toxicology of Selected Petroleum 33036)
Hydrocarbons. (30-31530)
Epidemiology Study [A Series of Nine] Inhalation Exposures of Toxicity 9 d . y
[Sprague-Dawley] Rats to Aerosolized
Final Report: A Coniparison of SMR, PMR, Diesel Fuel (30-3 i 53 1 ) Four-Week Oral Nephrotoxicity Screening
and PCMR [(Standardized Mortality [Project No. 14431 /Acute Toxicity Tests...API Study in Male F344 Rats [by Borriston
Ratios, Proportionate Mortality Ratios. and 79-6 Diesel Fuel (Marketplace Sample). Laboratories Inc.]. Final Report. (32-
Proportionate Center Mortality Ratios)] in (27-32817) 30966)

20

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L m 4 6 3 4 95 - 0732290 0549980 882

2f-DIMETHY LPROPANE Final Report: The Mortality among Members of FATE AND EFFECTS (LABORATORY
a Heavy Construction Equipment STUDY)
MetabolirnilPharrnacokinetics Operaiors Union with Potential Exposure
to Diesel Exhaust Emissions (30-31644) Animal Beluivior
Studies on the absorption of inhaled hydro- Job code classification system-2. Production
carbon vapors. Final report. (34-33036) operations and marketinghransportation Effects of crude oil and chemically dispersed
operations (33-30051) oil on chemoreception and homing in
EïBE Kidney Cancer Epidemiology in Petroleum- Pacific salmon. (34-32982)
Related Studies. (32-30420) Influence of Cnide oil and dispersant on the abi-
Odor and Tasie Risk Factors from a Population-Based Case- lity of coho salmon to differentiate home
-Control Study of Renal Cancer. (32- water from non-home water. (34-30590)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Odor threshold studies perfomied with gasoline 30419)


and gasoline combined with MTBE, Second Follow-Up Update, Independent Verifi- B ioaccumula tion
ETBE, and TAME. (41-01257) cation of Vital Status, and Clarification of
Cohort Definition and Initial Data Bioaccumulation of polycyclic aromatic hydro-
EPIDEMIOLOGY STUDY Collection of OH-1 Cohort. (32-31511) carbons and metals in estuarine organisms.
(40-30741)
A Health Survey of Petroleum Asphalt ETHANOL Laboratory Studies on the Effects of Oil on
Workers. (26-60093) Marine Organisms: An Overview (26-
A Morbidity Study of Petroleum Refinery Behavioral Siidy 60055)
Workers (26-60104) The Effects of Oil on Estuarine Animals:
A Mortality Study of Petroleum Refinery Behavioral Evaluation of Petroleum Toxicity, Uptake and Depuraïion,
Workers. (26-60120) Hydrocarbons. (30-32836) Respiration. (2660030)
A case-control study of kidney cancer among Uptake and Depuration of Specific Hydro-
petroleum refinery workers. Final report. ETHANOL (REVIEW) carbons from Oil by the Bi-vaives Rangia
(37-31336) cuneata and Crassostrea Virginia. (26-
A mortality study of marketing and marine Odor and Tasie 60072)
distribution workers with potential
exposure to gasoline in the petroleum [A literature] review of published odor and taste
industry. (39-33438) threshold values of [the 2761 soluble FATE AND EFFECTS (REVIEW)
A nested case-control study of kidney cancer, gasoline components. (33-30589)
leukemia and multiple myeloma in a Diseases
cohort of land-based terminai workers
exposed to gasoline in the petroleum ETHYLBENZENE Canceroos Diseases in Aquatic Animals and
industry. (4 1-32613) Their Association with Environmental
An Evaluation of the Significance of Hicnian Exposirre Assessnient Pollutants: A Critical Review of the
Experimental Hydrocarbon Toxicity to Literature (32-32656)
Man. (32-30421) Exposure data on C, and C, aromatics during
An exposure assessment for marketing and handling and production of motor
marine distribution workers in the gasolines. (33-3 1598) Oil Spills
petroleum industry with potential exposure
to gasoline (41-31765) MeiabolisrnlPharmacokineiics Petroleum in the freshwater environment ...An
An update of a mortality study of workers in annotated bibliography [covering]
petroleum refineries (33-32726) (Studies of the] Absorption, Distribution. and 1946-1983. (39-33456)
Assessment of the Healthy Worker Effect. Final Excretion of Ethylbenzene, Ethylcyclo- Review of natural resource damage assessments
Report. (3 i -30449) hexane, and Mehylethylbenzene Isomers in freshwater environments. Task 2.
Final Report of the Study of the Relationship in Rats (27-31528) Effects of oil releases into freshwater
between Carboxyhenioglobin on habitats. (39-3i 089)
Admission to the Subsequent Hospital n H Y LCYCLOHEXANE
Course of Patients Admitted to the
Myocardial Infarction Research Unit at the Meta bolisnilPharniacokineiics FLUORANTHENE
Johns Hopkins Hospital. (27-30965)
Final Report: A Comparison of SMR, PMR. [Studies of the] Absorption. Distribution, and Fure and Eflects
and PCMR [(Standardized Mortality Excretion of Ethylbenzene. Ethylcyclo-
Ratios, Proportionate Mortality Ratios. and hexane. and Methylethylbenzene Isomers Bioaccuniulation of polycyclic aromatic hydro-
Proportionate Center Mortality Ratios)] in in Rats (27-31528) carbons and metals in estuarine organisms.
a Cohort of [Heavy Equipment Operator] (40-30741)
Union Members, Potentially Exposed to ETHYLENE DICHLORIDE (REVIEW)
Diesel Exhaust Emissions (30-31639)
Final Report: The Cancer incidence among Nercrotoxicity Siirdy FLUORINE (REVIEW)
Members of a Heavy Construction
Equipment Operaiors Union with Potential Neurophysiological and Psychological Disorders Toxicity Study
Exposure to Diesel Exhaust Emissions and Occupational Exposure to Organic
(30-3 1645) Solvents. (31-37980) Fluorosis of Livestock. (26-60107)

21

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L X 4 6 3 4 95 0732290 0549983 739

FORMALDEHYDE 220-280 O F distillate fraction of unleaded Toxicity Study


gasoline (34-33108)
Toxicity Study The Evaluation of the Three-Month Inhalation
GASOLINE TEST FRACTION, Toxicity of Two Motor Fuels (27-32610)
A Survey of Eye Initation and Lachrymation in UNLEADED
Relation to Air Pollution (26-60052) GASOLINE, LEADED (REVIEW)
Toxicity Study
FUEL OILS (REVIEW) Toxicity Study
Four-Week Oral Nephrotoxicity Screening
Fate and Efects Study in Male F344 Rats [by Bomston Xenobiotic-Induced Kidney Lesions: Hydro-
Laboratories Inc.]. Final Report. (32- carbons. [A Synopsis ofl the 90-Day and
...
Petroleum in the freshwater environment An 30966) 2-Year Gasoline Studies. (32-30412)
annotated bibliography [covering] Hydrocarbon nephropathy in male rats: Identi-
1946-1983. (39-33456) ficaticm of the nephrotoxic components of GASOLINE, UNLEADED
unleaded gasoline (33-31098)
FULL-RANGEALKYLATENAPHTHA Thirteen-Week Inhalation Toxicity Study of a O Anolytical ChemistrylMethodalogy
to 145 "F Gasoline Distillate Fraction in
Toxicity Study Rats. Final Report. (32-32405) Evaluation of Four Air Sampling Methods Used
for Monitoring Worker Exposure to
Renal Toxicity of [Vapors ofl Gasoline and GASOLINE TEST FRACTION, Gasoline Vapors. (32-3023 1)
Related Petroleum Naphthas in Male Rats. UNLEADED (REVIEW)
(32-30414) Carcinogenicity study
Odor and Tasïe
GASOLINE (REVIEW) A Chronic Inhalation Study with Unleaded
[A literature] review of published odor and iaste Gasoline Vapor. (32-32227)
Carcinogenicity Stiidv threshold values of [the 276) soluble Chronic Gasoline Toxicity [Tests on Laboratory
gasoline components (33-30589) Animals]. (30-3 1991)
[A Review of] the Epidemiology of Renal Lifetime Dermal Carcinogenesis/Chronic
Carcinoma in Humans with a Note on the GASOLINE, LEADED Toxicity Screening Bioassay of Refinety
Effect of Exposure to Gasoline (32-30418) Streams in C3H/HeJ Mice. Three-Month
Epidemiology Study Toxicity Evaluation Report. [Vol. 1-21.
Fate and Effects (32-32653)
A mortality study of marketing and marine Lifetime dermal carcinogenesis/chronic toxicity
Petroleum in the freshwater environment ...An distribution workers with potential scmening bioassay of refinery streams in
annotated bibliography [covering] exposure to gasoline in the petroleum C3H/HeJ mice. Twelve-month toxicity
1946-1983. (39-33456) industry. (39-33438) evaluation repon. Final report. [Vol. 1-31.
A nested case-control study of kidney cancer, (33-3 1451)
Occupational Healih leukemia and multiple myeloma in a Lifetime dermal carcinogenesis bioassay of
cohort of land-based terminai workers refinery streams in C3H/HeJ mice
[Seven] Epidemiologic Studies of the Role of exposed to gasoline in the petroleum (AP-135R). (36-31364)
Gasoline (Hydrocarbon) Exposure in industry. (41-32613) Neoplastic Renal Effects of [Inhaled] Unleaded
Kidney Cancer Risk (32-3041 1) An exposure assessment for marketing and Gasoline in Fischer 344 Rats. (32-30413)
marine distribution workers in the The Carcinogenic Potential of Key Petroleum
Toxicity Study petroleum industiy with potential exposure Products. (30-31646)
to gasoline (41-31765)
A Review of the Human Kidney Effects of
Hydrocarbon Exposure (32-30410) Hiintan Exposure Assessment Developmental effects
Clinical toxicology of the acute ingestion of
methanol/hydrocarbon blends. A An exposure assessment for markeiing and Teratology Study in Rats. Unleaded Gasoline.
state-of-the-art review. (39-31093) marine distribution workers in the Final Report. (26-60014)
The Renal Effects of Petroleum Hydrocarbons, petroleum industry with potential exposure
Symp. (Boston 7/18-20/83) (32-01362) to gasoline (41-31765) Epideniiology stidy

GASOLINE T E S ï FRACTION Occriparional Health A mortality study of marketing and marine


distribution workers with potential
Carcinogenicity Study A niortality study of marketing and marine exposure to gasoline in the petroleum
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

distribution workers with potential industry. (39-33438)


The Carcinogenic Potential of Key Petroleum exposure to gasoline in the petroleum A nested case-control study of kidney cancer,
Products. (30-31646) industry. (39-33438) leukemia and multiple myeloma in a
A nested casecontrol study of kidney cancer, cohort of land-based terminal workers
Mutagenicity Stir+ leukemia and multiple myeloma in a exposed to gasoline in the petroleum
cohort of land-based terminal workers industry. (4 i -32613)
m i s final report on] the L5178Y TK+/-
mouse exposed to gasoline in the petroleum An exposure assessment for marketing and
lymphoma mutagenesis assay with API industry. (41-32613) marine distribution workers in the

22

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L r 4 6 3 4 95 = 0732290 0549982 655

petroleum industty with potential exposure Dominant Lethal Assay. Final Report. (28- Toxicity of Two Motor Fuels (27-32610)
to gasoline. (41-31765) 3 1344) [Project No. 14431 /Acute Toxicity Tests [of]
API #PS-6, Unleaded Moïor Gasoline (27-
Human exposure arsessnienl Research nieíhodology 32130)

A survey and analysis of liquid gasoline Feasibility Analysis for an Historical Prospec- GASOLINE, UNLEADED (REVIEW)
released to the environment during vehicle tive Mortality Study of Employees
refueling at service stations. (40-30807) Exposed to Downstream Gasoline in the Anaiylicai CkeniisiryiMeíhodology
Acute exposure to methanol in fuels: A Petroleum Industry. Final Report. (32-
prediction of ingestion incidence and 32565) Gasoline: Insights into the etiology of the
toxicity. (36-3 1914) Feasibility of Case-Control Studies of Kidney development of hepatocellular carcinoma
An exposure assessment for marketing and Cancer and Hydrocarbon Exposure among in the mouse. (41-30735)
manne distribution workers in the Petroleum Company Workers. (32-32225) Hydrocarbon Toxicity: Acuk, Subchronic and
petroleum industry with potential exposure Chronic Effects in Relation io Unleaded
to gasoline. (41-31765) Toxicity study Gasoline [(UG)] Exposure of Rodents,
Gasoline vapor exposure assessment at service with Comments on the Significance to
stations. (40-31953) A Chronic Inhalation Study with Unleaded Human Health. (32-30192)
Gasoline Vapor. (32-32227)
MetaóolismlPliarnmcokinetics Final Report. A four-week oral nephrotoxicity Toxicity Study
screening study in male F344 rats (33-
[In-vitro measurements of the] penetration of 31097) Hydrocarbon Toxicity: Acute, Subchronic and
benzene through human [abdominal] skin. Four-Week Oral Nephrotoxicity Screening Chronic Effects in Relation to Unleaded
(33-31225) Study in Male E344 Rats [by Bomston Gasoline [(UG)] Exposure of Rodents,
Laboratories Inc.]. Final Report. (32- with Comments on the Significance to
30966) Human Health. (32-30192)
Mutogenicity study Hydrocarbon nephropathy in male rats: Identifi- Summation/Comments on Sttucture-Activity
cation of the nephrotoxic components of Relationships. (32-30422)
Mutagenicity Evaluation of Petroleum unleaded gasoline (33-31098) Xenobiotic-Induced Kidney Lesions: Hydro-
Hydrocarbons. (30-31997) Hydrocarbon nephropathy in male rats. Tempo- carbons. [A Synopsis ofl the 90-Day and
Mutagenicity Evaluation of Unleaded Gasoline: ral and morphologic characterization of 2-Year Gasoline Studies. (32-30412)
Final Report. (28-30173) the renal lesions. (33-31223)
Rat Bone Marrow Cytogenetic Analysis [for] Kidney Effects of Unleaded Gasoline. Compre- GASOLINE-BASED PAINT SPRAY
Unleaded Gasoline. Final Report. (26- hensive and Critical Summary of Obser- (REVIEW)
60099) vations in Rats and Mice. (30-32845)
Unscheduled DNA synthesis in rat primary Lifetime demal carcinogenesis/chmic toxicity Toxicity Síudy
hepatocytes with PS-6 unleaded gasoline. screening bioassay of refinery streams in
its evaporation residue. and a DMSO C3Hkie.l mice. Twelve-month toxicity A Review of the Human Kidney Effects of
(dimethylsulfoxide) extract. (35-32431) evaluation report. Final report. [Vol. 1-31. Hydrocarbon Exposure (32-30410)
[Litton Bionetics Inc. Project No. 21141-021 (33-3145 1)
/Mutagenicity Evaluation of Gasoline. API Lifetime Dermal CarcinogenesislChronic
P S 6 Fuel (Unleaded) in ihe Mouse Toxicity Screening Bioassay of Refinery HEAVY CATALYTIC CRACKED
Dominant Lethal Assay. Final Report. (28- Streams in C3H/HeJ Mice. Three-Month NAPHTHA
3 1344) Toxicity Evaluation Report. [Vol. 1-21,
(32-32653) Carcinogenicity Síuúy
Neurotoxicity study Motor Fuel Chronic Inhalation Study...Unleaded
Gasoline. (32-32165) Lifetime dermal carcinogenesis/chronic toxicity
An Experimental Evaluation of Seleaed Non-Neoplastic Exposure-Related Renal screening bioassay of [ l i ] refinery
Petrochemicals for Subchronic Neurotoxic Lesions in [Fischer 344 Male] Rats streams in C3H/HeJ mice. Twelve-month
Properties. (30-32004) Following Inhalation of 167-2056 ppm) of toxicity evaluation. (34-32865)
Histopathological Analysis of Spinal Cord of Unleaded Gasoline Vapors (32-30407) Lifetime dermal carcinogenesiskhronic toxicity
Animals Exposed to Gasoline. Final Renal Toxicity of [Vapors of] Gasoline and screening bioassay of refinery streams in
Report. (30-30225) Related Petroleum Naphthas in Male Rats. C3HNe.J mice. Three-month toxicity
(32-304 14) evaluation report. Final report. (33-32010)
Odor and Taste Serial Sacrifice Study [by Bomston Twenty-four month dermal carcinogenesis/
Laboratories Inc.] with [API PS-61 chronic toxicity screening bioassay of
Odor threshold studies perfomied with gasoline Unleaded Gasoline in Rats. Final Report. refinery streams in C3HMeJ mice
and gasoline combined with MTBE. (32-31048) (AP-190r). Final Report. (36-33220)
ETBE, and TAME. (41-01257) The absence of hydrocarbon-induced nephro-
pathy in rats exposed subchronically to Mutagenicity Study
Reprodiictive eJecIs volatile hydrocarbon mixtures pertinent to
gasoline (34-30857) Mutagenicity of API 83-18. heavy catalytic
[Litton Bionetics Inc. Proj. No. 21141-021 The Acute Toxicology of Selected Petroleum cracked naphtha (petroleum) (CAS
/Mutagenicity Evaluation of Gasoline, API Hydrocarhons. (30-31530) 64741-54-4). in a mouse lymphoma
PS-6 Fuel (Unleaded) in the Mouse The Evaluation of the Three-Month Inhalation mutation assay. Final repon. (33-32804)

23
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
I A P I P U B L * 4 6 3 4 95 0732290 0 5 4 9 9 6 3 59L

Toxicity S i d y Mutagenicity Evaluation in the Mouse cracked naphtha (CAS 64741-83-9) in a


Lymphoma Fotward Mutation Assay, API mouse lymphoma mutation assay. Final
A 28-Day Dermal Toxicity Study in the Rabbit. #83-06, Heavy Catalytically Reformed report. (34-30632)
API 83-18, Heavy, Catalytically Cracked Naphtha. Final Report. (32-32460)
Naphtha (CAS 64741-54-4). Final Report.
(32-32748) Toxicity Siudy Toxicity Srirdy
Acute inhalation toxicity evaluation of a
petroleum-derived hydrocarbon in rats. A 28-Day Dermal Toxicity Study in the Rabbit. 28-day dermal toxicity in the rabbit. API 84-02,
API 83-18: Heavy catalytic cracked API [Sample] 83-06, Heavy Catalytically heavy thermally cracked naphtha (CAS

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
naphtha (CAS 64741-54-4). (34-32776) Reformed Naphtha (CAS 64741-68-0). 64741-83-9). Final report [by Tegeris
Acute oral toxicity study in rats. Acute dermal Final Report. (32-32752) Laboratories Inc.]. (33-316%)
toxicity study in rabbits. Primary dermal Acute Inhalation Toxicity Evaluation of a Acute oral toxicity study in rats. Acute dermal
irritation study in rabbits. Primary eye Petroleum-Derived Hydrocarbon in Rats. toxicity study in rabbits. Primaiy dermal
irritation study in rabbits. Dermal API #83-06. Heavy Catalytically initation study in rabbits. Primary eye
sensitization study in guinea pigs. API Reformed Naphtha. Final Report. (32- irritation study in rabbits. Dermal
83-18, heavy catalytically cracked naphtha 32169) sensitization study in guinea pigs. API
(CAS 64741-54-4). Final report. (33- Acute Oral Toxicity Study in Rats. Acute 84-02. heavy thermally cracked naphtha
30593) Dermal Toxicity Study in Rabbits. (CAS 64741-83-9). Final report. (33-
Four-Week Oral Nephrotoxicity Screening Primary Dermal Irritation Study in 30596)
Study in Maie F344 Rats [by Bomston Rabbits. Primary Eye Initation Study in Lifetime dermal carcinogenesis/chronic toxicity
Laboratories Inc.]. Final Report. (32- Rabbits. Dermal Sensitization Study in screening bioassay of [ l i ] refinery
30966) Guinea Pigs. API 83-06, Heavy streams in C3H/HeJ mice. Twelve-month
Lifetime dermal carcinogenesis/chronic toxicity Catalytically Reformed Naphtha (CAS toxicity evaluation. (34-32865)
screening bioassay of [ l i ] refinery 64741-68-0). (32-32860) Lifetime dermal carcinogenesis/chronic toxicity
streams in C3H/HeJ mice. Twelve-month Lifetime dennal carcinogenesis/chronic toxicity screening bioassay of refinery streams in
toxicity evaluation. (34-32865) screening bioassay of [ l i ] refinery C3H/Hd mice. Three-month toxicity
Lifetime d e m a l carcinogenesis/chronic toxicity streams in C3H/HeJ mice. Twelve-month evaluation report. Final report. (33-32010)
screening bioassay of refinery streams in toxicity evaluation. (34-32865) Twenty-four month dermal carcinogenesis/
C3H/HeJ mice. Three-month toxicity Lifetime dermal carcinogenesis/chronic toxicity chronic toxicity screening bioassay of
evaluation report. Final report. (33-32010) screening bioassay of refinery streams in refinery streams in C3H/HeJ mice
Twenty-four month dermal carcinogenesis/ C3H/HeJ mice. Ihree-month toxicity (AP-190r). Final Report. (36-33220)
chronic toxicity screening bioassay of evaluation report. Final report. (33-32010)
refinery streams in C3H/HeJ mice Renal Toxicity of [Vapors of] Gasoline and
(AP-190r). Final Report. (36-33220) Related Petroleum Naphthas in Male Rats. n-HEPTANE
(32-304 14)
HEAVY C A T A L Y T I C REFORMED Twenty-four month dermal carcinogenesis/ MeîabolismlPliarmarokineiics
NAPHTHA chronic toxicity screening bioassay of
refinery streams in C3H/HeJ mice Studies on the absorption of inhaled hydro-
Carcinogenicity Study (AP-190r). Final Report. (36-33220) carbon vapors. Final report. (34-33036)

Lifetime dermal carcinogenesis/chronic toxicity HEAVY THERMAL CRACKED NAPHTHA Neuroioxiciry Sruúy
screening bioassay of [ i l ] refinery
streams in C3H/HeJ mice. Twelve-month Carrinogeniciry Sirrdy An Expenmenial Evaluation of Selected
toxicity evaluation. (34-32865) Petrochemicals for Subchronic Neurotoxic
Lifetime dennal carcinogenesis/chronic toxicity Lifetime dermal carcinogenesis/chronic toxicity Properties. (30-32004)
screening bioassay of refinery streams in screening bioassay of [ i l ] refinery
C3H/HeJ mice. Three-month toxicity streams in C3H/HeJ mice. Twelve-month
evaluation report. Final repon. (33-32010) toxicify evaluation. (34-32865)
Twenty-four month demial carcinogenesis/ Lifetime dermal carcinogenesis/chronic toxicity [Bio/dynamics lnc. Project No. 78-72331 /A
chronic toxicity screening bioassay of screening bioassay of refinery streams in (26- Week Inhalation Toxicity Study of
refinery streanis in C3WHeJ mice C3Hkie.I niice. Three-month toxicity Heptane in the Rat. (28-31209)
(AP-190r). Final Report. (36-33220) evaluation report. Final report. (33-32010)
Twenty-four month dermal carcinogenesis/
Muiagenicity Siudy chronic toxicity screening bioassay of HETEROCYCLIC POLYNUCLEAR
refineiy streams in C3H/HeJ mice AROMATIC COMPOUNDS
Activity of API 83-06 (heavy catalytic reformed (AP-190r). Final Report. (36-33220)
naphtha) in the acute in vivo cytogenetics Analytical ChemisrryIMeihodology
assay in male and female rats. Final Mitîageniriry Siir&
report. (33-30494) A Draft Final Report [by Batteile Columbus
L5178Y TK+/- Mouse Lymphoma Mutagenesis Acute inhalation toxicity evaluation of a Laboratories] on [Its] Development of a
Assay. API 83-06. heavy catalytically petroleum-derived hydrocarbon in rats. Method for Measurement of Heterocyclic
reformed naphtha (CAS 64741 -68-0). API 84-02: Heavy thermal cracked [Polynuclear] Aromatic Compounds
Final report [by Microbiological naphtha (CAS 64741 -83-9). (34-32778) [(Helero-PACs)] in Petroleum Samples
Associates Inc.]. (33-31641) Mutagenicity of API 84-02. heavy thermal (3 1-31471 )

24

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L 8 4 6 3 4 95 E 0 7 3 2 2 9 0 0549984 4 2 8 E

HEXACHLOROBUTADIENE (REVIEW) Neurotoxicity. Final Report. (29-32291) An acute operant behavior study of inhaled
Neurobehavioral Effects of Subchronic commercial hexane in the Albino rat. (37-
Carcinogenicity Study Exposure of Weanling Rats to Toluene or 31153)
Hexane. (30-32008)
A Brief Review of [Published Data on] the Neuropathic Potential of n-Hexane in the Carcinogenicity siudy
Toxicity and Carcinogenicity of Select Presence of Other Hexane Isomers. Final
Chlorinated Hydrocarbons. (32-30417) Report: [Phase 1 and Phase 21. (30-30226) An inhalation oncogenicity study of commercial
Quantitative Analysis of Pathological Changes hexane in rats and mice--2. Mice. Final
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Toxicity Study in the Cervical Spinal Cord of Control and report. (41-33232)
n-Hexane-Treated Rats. Final Report. (30- An inhalation oncogenicity study of commercial
A Brief Review of [Published Data on] the 30223) hexane in rats and mice--l. Rats. Final
Toxicity and Carcinogenicity of Select Six-Month Continuous Inhalation Exposures of report. (41-33231)
Chlorinated Hydrocarbons. (32-30417) Rats to Hexane Mixtures ...Phase II. (30-
32846) Developntenral eflects
HEXA DECANE [Bio/Dynamics Inc. Project No. 77-19211 /A
26-Week Inhalation Toxicity Study of A single-generation inhalation reproduction/
MetabolismlPliarmacokinetics n-Hexane in the Rat. (28-30077) fertility study on a commercial hexane.
(33-32864)
[In-vitro measurements of the] penetration of Toxicity Srirdy Developental toxicity study of commercial
benzene through human [abdominal] skin hexane vapor in CD(TM)-l mice. (36-
(33-31 225) Four-Week Oral Nephrotoxicity Screening 33318)
Study in Maie F344 Rats [by Bomston Developniental toxicity study of commercial
n-HEXANE Laboratories Inc.]. Final Report. (32- hexane vapor in CD(TM) (Sprague-
30966) Dawley) rats. (36-33319)
Behavioral Study Six Month Continuous Inhalation Exposures of Final Report, April 17, 1991. Commercial
Rats to Hexane Mixtures. Phase I. (30- hexane test rule, 40 CFR 799.2155.
Behavioral Evaluation of Petroleum 32858) Two-generaticm reproduction study of
Hydrocarbons. (30-32836) The Inhalation Toxicity of n-Hexane and inhaled commercial hexane in CD(TM)
Methyl Ethyl Ketone. (30-32005) (Sprague-Dawley) rats. (3 8-3 1216)
Developmental Eflects Final Repon, April 17. 1991. Commercial
hexane test rule, 40 CFR 799.2155. Two-
Teratology Study in Rats. n-Hexane. Final n-HEXANE (REVIEW) Generation reproduction study of inhaled
Report. (27-32177) commercial hexane in CD(TM) (Sprague-
Huntan Exposirre Assessrneni Dawley) rats. (38-31217)

Use of biological monitoring and biomarkers. Meta bolisnilfliarniocokinetics


Disposition and pharmacokinetics of com- State-of-the-art review. (40-32427)
mercial hexane following IV bolus, Disposition and pharmacokinetics of commer-
dermal absorption o r nose-only Merabolisnrlfharniacokinerics cial hexane following IV bolus, dermal
inhalation ...Final report. (39-33 107) absorption or nose-oniy inhalation ...Finai
Studies on the absorption of inhaled hydro- The Effects of n-Hexane in Man and Animais. report. (39-33107)
carbon vapors. Final report. (34-33036) (30-3 1603)
Mitragenicity s i i d y
Mutagenicity Srudy Neuroroxicity Sir&
Salnionella/mammalian-microsomemutagenicity
In-Vivo and In-Vitro Mutagenicity Studies. A Tale of Two Solvents: The Neurology of assay of the vapor phase of commercial
n-Hexane (Tiexam UV). Final Report. n-Hexane and Toluene. (30-32079) hexane using the desiccator methodology.
(28-3 1628) Neurophysiological and Psychological Disorders (36-32641)
[Final Report on the] Mutagenicity Evaluation and Occupational Exposure to Organic CHO [(Chinese hamster ovaiy)]/HGPRT muta-
of n-Hexane in the Mouse Dominant Solvents. (31-32980) tion assay of commercial hexane, Final
Lethal Assay. (27-32179) Neurotoxicity of organic solvents with special Report. (37-31487)
reference tothe neurobehavioral effects: A Cliromosonie aberrations in Chinese hamster
Neuroroxicity Sr& [world] literature review (39-30623) ovary (CHO) cells exposed to commercial
The Effects of n-Hexane in Man and Animals. hexane. (37-31 152)
A Comparison of the Raie of Development of (30-31603) Subchronic in-vivo cytogenetics assay in rats
Hexane Neuropathy in Weanling and using nose-only inhalation exposure to
Young Adult Rats. (30-32007) coiiiniercial hexane. Final report. (37-
An Experimental Evaluation of Selecied Petro- HEXANE, COMMERCIAL 3 1830)
chemicals for Subchronic Neurotoxic
Properties. (30-32004) Behavioral study Neurotoxicity srudy
Concentration-Related Effects of Hexane on
Evoked Responses from Brain and A 13 week inhalation study of potential effects A 13 week inhalation study of potential effects
Peripheral Nerve. (30-32006) of commercial hexane on behavior and of commercial hexane on behavior and
Experimental Studies of Hexacarbon neuromorphology in rats. (37-31154) neuromorphology in rats. (37-3 1154)

25

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API PUBL*4634 95 0 7 3 2 2 9 0 0 5 4 9 9 8 5 364

Reprodirciive effecis Mutagenicity Study of ïhirteen Petroleum associated with seven bulk gasoline
Fractions. (2640098) storage facilities in N o h Carolina. (40-
A single-generation inhalation reproduction/ 32761)
fertility study on a commercial hexane. Toxicity Stirdy Exposure data on C, and CI, ammatics during
(33-32864) handling and production of motor
Final Report, April 17, 1991. Commercial Petroleum Hydrocarbon Toxicity Studies--14. gasolines. (33-31598)
hexane test d e , 40 CFR 799.2155. Animal and Human Response to Vapors Gasoline vapor exposure assessment at service
Two-generation reproduction study of of "High Aromatic Solvent" (27-31349) stations. (40-31953)
inhaled commercial hexane in C D o Impact on Human Health of Petroleum in the
i (Sprague-Dawley) rats. (38-31216) HIGH FLASH AROMATIC NAPHTHA Marine Environment. (32-32651)
I
Final Report, April 17. 1991. Commercial Indoor vs. outdoor ambient benzene concen-
hexane test nile, 40 CFR 799.2155. Muragenicity Srudy trations: Results of the EPA Total
Two-Generation reproduction study of Exposure Assessment [Methodology]
inhaled commercial hexane in C D o The mutagenic potential of high flash aromatic (TEAM) study. (35-31189)
(Sprague-Dawley) rats. (38-31217) naphtha. (36-33132) Industrial Hygiene Assessment of Petroleum
Refineiy Turnaround Activities. Final
Toxicity study HIGH NAPHTHENIC SOLVENT Report. (32-31555)

A thirteen week inhalation toxicity study of Toxicity Siuúy Job Code Classification System--l. Petroleum

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
commercial hexane in the rat and mouse. Refineries and Selected Petrochemical
(37-31151) Petroleuni Hydrocarbon Toxicity Studies--15. Operations. (27-32280)
Special pathology rep0rt... A thirteen-week Animal Response to Vapors of "High Monitoring near refineries for airborne chemical
inhalation toxicity study of commercial Naphthenic Solvent" (27-3 1350) on the SARA [(Superfund Amendments
hexane in the rat and mouse. (37-31148) and Reauthorization Ac1 of 198611 Title
HIGH-SOLVENCY NAPHTHA III Section 313 list. Volume I...Validated
2,5-HEXANEDIONE ambient air concentrations around three
Mittugeniciry Sriddy refineries. (36-32657)
Neurotoxicity Study Monitoring near refineries for airborne
Estimation of the Mutagenicity of Hydrocarbon chemicals on the SARA [(Superfund
Experimental Studies of Hexacarbon Fractions Utilizing the Bacterial Assay Amendments and Reauthorization Act)]
Neurotoxicity. Final Report. (29-32291) Procedure with Mammalian Tissue Title II1 Section 313 List--2. A Generic
Metabolic Activation. API Project PS-4 Study Design Protocol. (40-30722)
HEXANES, MIXED #6. (26-60103) Monitoring near refineries for a i h r n e
chemicals on the SARA [(Superfund
Neuroioxicity Stirdy HUMAN EXPOSURE ASSESSMENT Amendments and Reauthorization Act)]
Title III Section 313 List--3. Literature
A Comparison of the Raie of Development of "Normal" Carboxyhemoglobin [COHb] Levels survey/Monitoring data for selected
Hexane Neuropathy in Weanling and of Blood Donors in the U.S. (2640048) chemicals in airborne emissions. (40-
Young Adult Rats. (30-32007) A survey and analysis of liquid gasoline 30723)
Neuropathic Potential of n-Hexane in the released to the environment during vehicle Monitoring near refineries for airborne
Presence of Other Hexane Isomers. Final refueling at service stations. (40-30807) chemicals on the SARA [(Superfund
Report: [Phase 1 and Phase 21. (30-30226) Acute exposure to methanol in fuels: A Amendments and Reauthorization Act)]
Six-Month Continuous Inhalation Exposures of prediction of ingestion incidence and Title II1 Section 313 List--4. A sampling
Rats to Hexane Mixtures ...Phase II. (30- toxicity. (36-31914) and analytical protocol for selected chem-
32846) Acute exposure to methanol in fuels: A icals in airborne emissions. (40-30724)
prediction of ingestion incidence and N-Nitroso Compounds in Airborne Respirable
Toxicity S r d y toxicity. (36-3 1914) Paniculate Matter. (29-32752)
An exposure assessment for marketing and Numerical Modeling of Ozone Population
Six Month Continuous Inhalation Exposures of manne distribution workers in the Exposure: Application to a Comparison of
Rats to Hexane Mixtures. Phase I. (30- petroleum industry with potential exposure Altemative Ozone Standards. Final
32858) to gasoline (41-31765) Report. (32-32309)
Analysis of foods for benzene. (40-32424) Occupational Exposure to' Benzene in the
HIGH AROMATIC SOLVENT Benzene levels in ambient air and breath of Petroleum and Petrochemical industries.
smokers and nonsmokers in urban and (30-31525)
Developmental Effecls pristine environments (33-32727) Oils Mist: [An] Evaluation of [Workplace]
Carboxyhemoglobin Trend in Chicago Blood Sampling Procedures. (26-601 IS)
Teratology Study in Rats. High-Aromatic Donors. 1970-1974. 2430057) Photochemical Smog. (2640108)
Solvent. Final Report. (27-32176) Carboxyhemoglobin Trend in St. Louis Blood Produced water radionuclide hazard/risk
Donors, 1971-1975. CRC-APRAC Project assessment. Phase 1. (39-31094)
Mutagenicity Si* NO. CAPM-8-68. (27-30705) Statistical approaches for assessing exposures to
Development and Persistence of Adaptation IO chemicals. (33-31 163)
Furiher Studies of the Mutagenicity of Ozone Exposure in Ozone-Sensitive T h e Influence of Trace Metals in Disperse
Hydrocarbon Fractions [by] Utilizing Southem California Residents. (28-33073) Aerosols on the Human Body Burden of
Sanatic Mutations in Rats. (26-60100) Estimation of incremental benzene exposure Trace Metais. (27-30840)

26

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L x 4 6 3 4 9 5 IO732290 0549986 2 T O m

The Use of Panelists as Substitutes for Taxicab Report. (32-30965) Streams in C3HIHeJ Mice. Three-Montt
Drivers in Carbon Monoxide Exposure Mutagenicity in a mouse lymphoma mutation Toxicity Evaluation Report. [Vol. 1-2)
(2660053) assay. API 81-10, hydrodesulfunzed (32-32653)
Trace Metals in Urban Aerosols. (26-60094) middle distillate (CAS 64742-80-9). Final Twenty-Eight-Day Dermal Toxicity Study ir
Use of biological monitoring and biomarken. report. (33-31224) the Rabbit of Hydrodesulfurized Middk
State-of-the-art review. (40-32427) Mutagenicity of APl 81-10, hydrodesulfurized Distillate. [API] Sample 81-09. Fina
middle distillate (CAS 64742-80-9) (coded Report. (30-32298)
HYDROCARBON SOLVEhTS (REVIEW) as APl 86-10) in a mouse lymphoma Twenty-Eight-Day Dermal Toxicity Study ir
mutation assay. Final report. (34-32643) the Rabbit of Hydrodesulfunzed Middlc
Toxicity S r d y Mutagenicity of API 81-10 SAT, saturated Distillate, [API] Sample 81-10. [bl
fraction of hydrodesulfunzed middle Bomston Laboratories inc.]. Final Report
A Review of the Human Kidney Effects of distillate (CAS 64742-80-9) (coded as API (30-322%)
Hydrocarbon Exposure (32-30410) 86-10 SAT) in a mouse lymphoma
mutation assay. Final report. (34-32645) HYDROGEN SULFIDE (REVIEW)
HYDROCARBONS Mutagenicity of API 81-10 ARO, aromatic
fraction of hydrodesulfunzed middie Neurotoxicity Study
Hunion Exposure Assewnetit distillate (CAS 64742-80-9) (coded as API
86-10 ARO) in a mouse lymphoma Neurotoxicity of organic solvenis with specia
Monitoring near refineries for airborne chemical mutation assay. Final report. (34-32644) reference to the neurobehavioral effects: P
on the SARA [(Superfund Amendments Sister chromatid exchange assay in Chinese [world] literature review (39-30623)
and Reauthorization Act of 1986)l Title hamster ovary (CHO) cells with APl
III Section 313 list. Volume LValidated 81-10: Hydrodesulfunzed middle distillate. To.ricity S r d y
ambient air concentrations around three Final report. (35-32433)
refineries. (36-32657) Gaseous and Particulate Sulfur Compounds ii
Toxirip study Urban Atmospheres. (26áo070)
H Y D R ODES U LFU R iZED M I DD L E
DISTILLATE Acute Toxicity Studies [by Hazleton Raltech HY DROTREATED HEAVY NAPHTHENI(
Inc. 04 Hydrodesdfurized Middle DISTILLATE
Carcinogenicity study Distillate, [API] Sample 81-10. (30-32348)
Acute Toxicity Studies [by Hazleton Raltech Mutagenicip Sru4
Lifetime Dermal Carcinogenesis/Chronic Inc. ofl Hydrodesuifuriled Middle
Toxicity Screening Bioassay of Refinery Distillate, [API] Sample 81-09. (30-32347) CHOMGPRT [(Chinese Hamster Ovary/ Hypo
Streams in C3HMeJ Mice. Three-Month Dermal Sensitization Study in Guinea Pigs. xanthine-Guanine Phosphoribosyl Trans
Toxicity Evaluation Report. [Vol. 1-21. Closed Patch Technique. ferase)] Mammalian Cell Forward Gen1
(32-32653) Hydrodesulfunzed Middle Distillate. API Mutation Assay of API 81-15. (32-32118
Lifetime dermal carcinogenesiskhronic toxicity Sample 81-10. (31-31414) Mutagenicity of API 83-15, hydrotreated heay
screening bioassay of refinery streams in Dermal Sensitization Study in Guinea Pigs. naphthenic distillate, (CAS 64742-52-5:
C3HfiIeJ mice. Twelve-month toxicity Closed Patch Technique. in a mouse lymphoma mutation assay
evaluation repon. Final report. [Vol. 1-31. Hydrodesulfunzed Middle Distillate, API Final repon. (33-32800)
(33 -31451) Sample 81-09. (31-31352)
Lifetime dermal carcinogenesis bioassay of Four-week subchronic inhalation toxicity study Toxicity S r d y
refinery streams in C3WHeJ mice in rats. Final report. API 81-07.
(AP-l35R). (36-3 1364) hydrodesulfunzed kerosine (petroleum) 28-Day dermal toxicity study of API 83-12
Short-term dermal tumorigenesis study of selec- (CAS 64742-81-0). API 81-09, hydrotreated heavy naphthenic distillat
ted petroleum hydrocarbon [processing hydrodesulfurized middle distillate (CAS 64742-52-5). in the rabbit. Fina
fractions] in male CD-1 mice. Initiation (petroleum) (CAS 64742-80-9). API report. (35-32430)

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
and promotion phases. (36-32643) 81-10. hydrodesulfunzed middle distillate Acute oral toxicity study in rats. Acute derma
(petroleum) (CAS 64742-80-9). (33- toxicity study in rabbits. Primary denna
Mutagenicity study 32724) imtaiion study in rabbits. Primary ey
LC, Acute Inhalation Toxicity Evaluation of a imfation study in rabbits. Derma
In-vivo sister chromatid exchange assay with Petroleum-Derived Hydrocarbon in sensitization study in guinea pigs. AP
API 81-10: Hydrodesulfunzed middle Rats ...Hydrodesulfunxd Middle Distillate. 83-15, hydrotreated heavy naphtheni
distillate. Final report. (35-32479) API Sample 81-10. (30-32857) distillate (CAS 64742-52-5). Final repoi
Mutagenicity Evaluation Studies [of LC, Acute Inhalation Toxicity Evaluation of a [by Hazleton Laboratories America Inc.
Hydrodesulfurized Middle Distillate (D). Petroleum-Derived Hydrocarbon in (33-32639)
API Sample 81-10] in the Rat Bone Rais ...Hydrodesulfurized Middle Distillate,
Marrow Cytogenetic Assay and in the API Sample 81-09. (30-32856)
Mouse Lymphoma Forward Mutation Lifetime demial carcinogenesis/chronic toxicity HYDROTREATED LIGHT NAPHTHENU
Assay. Final Report. (32-30535) screening bioassay of refinery streams in DISTILLATE
Mutagenicity Evaluation Studies in the Rat C3HMel mice. Twelvemonth toxicity
Bone Marrow Cytogenetic Assay and in evaluation report. Final report. [Vol. 1-31. Carcinogenicity Sruày
the Mouse Lymphoma Forward Mutation (33-3145 i)
Assay. Hydrodesulfurized Middle Lifetime Dermal CarcinogenesislChronic Lifetime dermal carcinogenesiskhronic toxicit
Distillate, API Sample 81-09. Final Toxicity Screening Bioassay of Refinery screening bioassay of [ l i ] refinery

27

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 0 7 3 2 2 9 0 0549967 137 =

streams in C3HkieJ mice. Twelve-month Ketone]. (30-32013) J E T FUEL A


toxicity evaluation. (34-32865) The absence of hydrocarbon-induced nephro-
Lifetime dermal carcinogenesis/chronic toxicity pathy in rats exposed subchronically to Developmental Effects
screening bioassay of refinery streams in volatile hydrocarbon mixtures pertinent to
C3H/HeJ mice. Three-month toxicity gasoline (34-30857) Inhalation Teratology of Jet Fuel A, Fuel Oil,
evaluation report. Final report. (33-32010) Thirteen-Week Inhalation Toxicity Study of C4/ and Petrolum Naphtha in Rats. (30-32003)
Twenty-four month dermal carcinogenesis/ C5 Hydrocarbon Blends in Rats. Final lnhalationíïeratology Study in Rats. Jet Fuel A.
chronic toxicity screening bioassay of Report. (32-31472) Final Report. (27-32173)
refinery streams in C3H/HeJ mice
(AP-190r). Final Report. (36-33220) ISOOCTANE Mutagenictry Study

Mutagenicity Study MetabolismlPharmacokinetics in-Vitro and In-Vivo Mutagenicity Studies. Jet


Fuel A. Final Report. (27-30051)
Mutagenicity of API 83-12, hydrotreated light Studies on the absorption, tissue equilibria and Mutagenicity Evaluation of Petroleum Hydro-
naphthenic distillate (CAS 64742-53-6) in excretion routes of inhaled hydrocarbon carbons. (30-31997)
a mouse lymphoma mutation assay. Final vapors and their metabolites (36-31430) Mutagenicity Evaluation of Six Petroleum
report. (33-32802) The Absorption of Petroleum Products across Substances in an In-Vivofln-Vitro Urine
the Skin of Monkey and Man: AM& Assay. (30-31037)
Toxicity Study Report, Jan. 1, 1984 to Dec. 31, 1984. [Linon Bionetics Inc. Project No. 21141431
(32-32749) Mutagenicity Evaluation of Jet Fuel A in
28-day dermal toxicity study in the rabbit: API [in-vitro measurements of the] penetration of the Mouse Dominant Lethal Assay. Final
83-12 hydrotreated light naphthenic benzene through human [abdominal] skin Report. (28-31345)
distillate (CAS 64742-53-6). Final report. (33-31225)
(33-30499) Reprodrictive Effects
Acute inhalation toxicity evaluation of a ISOPENTANE
petroleum-derived hydrocarbon in rats. [Litton Bionetics Inc. Proj. No. 2114143]
API 83-12: Hydrotreated light naphthenic MetabolisnilPharniocokinetics Mutagenicity Evaluation of Jet Fuel A in
distillate (CAS 64742-53-6). (34-32775) the Mouse Dominant Lethal Assay. Final
Acute oral toxicity study in rab. Acute dermal Studies on the absorption of inhaled hydro- Report. (28-3 1345)
toxicity study in rabbits. Primary dermal carbon vapors. Finai report. (34-33036)
imtation study in rabbits. Primary eye Toxicity Study
irritation study in rabbits. Dermal sensi- Toxiciry Siudy
t i a i o n study in guinea pigs. API 83-12, The Acute Toxicology of Selected Petroleum
hydrotreated light naphthenic distillate, The absence of hydrocarbon-induced nephro- Hydrocarbons. (30-3 1530)
CAS 64742-53-6. Final report. (33-30592) pathy in rats exposed subchronicaliy to [Project No. 14431 /Acute Toxicity Tests of
Lifetime dennal carcinogenesislchronic toxicity volatile hydrocarbon mixtures pertinent to API Jet Fuel A (27-32815)
screening bioassay of [ l i ] refinery gasoline (34-30857)
streams in C3H/HeJ mice. Twelve-month Thirteen-Week Inhalation Toxicity Study of
toxicity evaluation. (34-32865) C4K5 Hydrocarbon Blends in Rats. Final JET PROPULSION FUEL
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Lifetime dermal carcinogenesis/chronic toxicity Report. (32-31472)


screening bioassay of refinery streams in A naìytica I ChemistrylMethoaòlogy
C3H/HeJ mice. Three-month toxicity ISOPROPANOL (REVIEW)
evaluation report. Final report. (33-32010) [APl Projeci SPS-5-UOC(858/305)] Compre-
Twenty-four month dermal carcinogenesis/ Odor and Taste hensive Analyses of Shale Oil Products:
chronic toxicity screening bioassay of Second Study. Final. (28-70300)
refinery streams in C3HkieJ mice [A literature] review of published odor and taste
(AP-190r). Final Report. (36-33220) threshold values of [the 2761 soluble Toxicity Stiuìy
gasoline components (33-30589)
ISOBUTANE Pathologic Findings in Laboratory Animals
JP-5 Exposed to Hydrocarbon Fuels of Military
Meta bolisnilPkarmacokinetics Interest. (32-30416)
Toxicity Study Toxicology of Mixed Distillate and High-
Studies on the absorption of inhaled hydro- Energy Synthetic Fuels. (32-30415)
carbon vapors. Final report. (34-33036) Interactive Effects of JP-5 Vapor Exposure and
Elevated Temperature on Renal Lesion
Toxicity Stidy Induction [in Rats]. (30-31537) KEROSENE see KEROSINE

The Myocardial Toxicity [to Dogs] of Selected JET FUEL (REVIEW)


Aliphatic Hydrocarbons, [Including KEROSINE
Propane (P), n-Butane. lsobutane. and a Neuroiox¿city Study
Mixture of niese Hydrocarbons (A-46). Developmental E/fects
and Mixtures of Isobutane with Methyl Neurophysiological and Psychological Disorders
Chloroform. Trichloroethylene. Methyl and Occupational Exposure to Organic Teratology Study in Rats. Kerosene. Final
Ethyl Ketone. and Methyl Isobutyl Solvents. (31-32980) Report. (27-32175)

28

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 9 5 EH 0 7 3 2 2 9 0 05Yï988 073

Mutagenicity Study fractions] in male CD-1 mice. Initiation streams in C3H/HeJ mice. Twelve-month
and promotion phases. (36-32643) toxicity evaluation. (34-32865)
Mutagenicity Evaluation of Kerosene. Final Lifetime dermal carcinogenesislchronic toxicity
Report. (26-60017) Mutagenicity Study screening bioassay of refinery streams in
Mutagenicity Evaluation of Petroleum Hydro- C3H/HeJ mice. Three-month toxicity
carbons. (30-31997) In vivo sister chromatid exchange assay with evaluation report. Final report. (33-32010)
API 81-07. hydrodesulfurized kerosine. Twenty-four month dermal carcinogenesis/
KEROSINE (REVIEW) Final report. (36-30043) chronic toxicity screening bioassay of
Mutagenicity Evaluation Studies in the Rat refinery streams in C3H/HeJ mice
Chemical Countermeasures Bone Marrow Cytogenetic Assay [and] in (AP-190r). Final Report. (36-33220)
the Mouse Lymphoma Forward Mutation
Petroleum in the freshwater environnient ...An Assay. Hydrodesulfurized Kerosine, API
annotated bibliography [covering] Sample 81-07. Final Report. (32-30240) Mutagenicity Study
1946-1983. (39-33456)
Toxicity Study L5178Y TK+/- Mouse Lymphoma Mutagenesis
Fate and Effects Assay. API [Sample] 83-09, Straight-Run
A Dermal Sensitization Study in [50] Guinea Kerosine (CAS 8008-206). Final Report.
Petroleum in the freshwater environment ...An Pigs [by the] Closed Patch Technique (32-32745)
annotated bibliography [covering] [with the Use of] API Sample 81-07 The Acute In-Vivo Cytogenetics Assay in Male
196-1983. (39-33456) [(Hydrodesulfurized Kerosine)]. (31- and Female Rats of API 83-09
31413) [(Straight-Run Kerosine)]. Final Report.
Toxicity Study Acute Toxicity Studies [by Hazleton Raltech (32-3 1769)
Inc.] of Hydrodesulfurized Kerosine,
Clinical toxicology of the acute ingestion of [AH] Sample 81-07. (30-31986)
meihanol/hydrocarbon blends. A Four-week subchronic inhalation toxicity study Toxicity Stidy
state-of-the-art review. (39-3 1093) in rats. Finai report. API 81-07,
hydrodesulfurized kerosine (petroleum) 28-day dermal toxicity study in the rabbit: API
KEROSINE, DEODORIZED (CAS 64742-81-0). API 81-09, hydro- 83-09 straight run kerosine (CAS
desulfurized middle distillate (petroleum) 8008-20-6). Final report. (33-30443)
Mutagenicity Study (CAS 64742-80-9). API 81-10. hydro- Acute inhalation toxicity evaluation of a
desulfurized middle distillate (petroleum) petroleum-derived hydrocarban in rats,
Estimation of the Mutagenicity of Hydrocaibon (CAS 64742-80-9). (33-32724) API 83-09, straight-run kerosine (CAS
Fractions Utilizing the Bacterial Assay LC, Acute Inhalation Toxicity Evaluation of a 8008-20-6). Final report. (34-30634)
Procedure with Mammalian Tissue Petroleum-Derived Hydrocarbon in Acute Oral Toxicity Study in Rats. Acute
Metabolic Activation. API Project PS-4 Rats ...Hydrodesulfurized Kerosine, API Dermal Toxicity Study in Rabbits.
#6. (26-60103) Sample 81-07. (30-32855) Primary Dermal Irritation Study in
Mutagenicity Study of Thirteen Petroleum Lifetime Dermal CarcinogenesislChronic Rabbits. Primary Eye Irritation Study in
Fractions. (26-60098) Toxicity Screening Bioassay of Refinery Rabbits. Dermal Sensitization Study in
Streams in C3H/HeJ Mice. Three-Month Guinea Pigs. API 83-09, Straight Run
Toxicity Siuúy Toxicity Evaluation Repon. [Vol. 1-21, Kerosine (CAS 8008-20-6). (32-32858)
(32-32653) Lifetime dermal carcinogenesis/chronic toxicity
Petroleum Hydrocarbon Toxicity Studies--1 1. Lifetime dermal carcinogenesis bioassay of screening bioassay of [ i l ] refmery
Animal and Human Response to Vapors refinery streams in C3H/HeJ mice streams in C3HMeJ mice. Twelve-month
of Deodorized Kerosene (26-60089) (AP-I 35R). (36-3 1364) toxicity evaluation. (34-32865)
Lifetime dermal carcinogenesiskhronic toxicity Lifetime dermal carcinogenesis/chric toxicity
KEROSINE, HYDRODESULFURIZED screening bioassay of refinery streams in screening bioassay of refinery streams in
C3H/HeJ mice. Twelve-month toxicity C3H/HeJ mice. niree-month toxicity
Carcinogenicity Stiidy evaluation report. Final report. [Vol. 1-31, evaluation report. Final report. (33-32010)
(33-3 1451) Twenty-four month dernial carcinogenesis/
Lifetime Dermal CarcinogenesislChronic Short-term dermal tumorigenesis study of selec- chronic toxicity screening bioassay of
Toxicity Screening Bioassay of Refinery ted petroleum hydrocarbon [processing refinery streams in C3H/HeJ mice
Streams in C3H/HeJ Mice. Three-Month fractions] in male CD-1 mice ...initiation (AP-190r). Final Report. (36-33220)
Toxicity Evaluation Report. [Vol. i -21. and promotion phases. (36-32643)
(32-32653) Twenty-Eight-Day Dermal Toxicity Study in
Lifetime dermal carcinogenesis bioassay of the Rabbit of Hydrodesulfurized Kerosine, LEAD
refinery streams in C3H/HeJ mice [API] Sample 81-07. Final report. (30-
(AP-l35R). (36-3 1364) 32297) MetabolismlPharniacokinetics
Lifetime dermal carcinogenesis/chronic toxicity
screening bioassay of refinery streams in KEROSINE, STRAIGHT-RUN A Metabolic Model of Lead Kinetics Based
C3H/HeJ mice. Twelve-month toxicity upon Measured Organic Burdens during
evaluation report. Final report. [Vol. 1-31, Carcinogenicio Study Chronic Exposure Experiments with 1661
(33-31451) Infant and Juvenile Baboons. (31-30264)
Short-tem d e m a l tumorigenesis study of selec- Lifetime dermal carcinogenesis/clironic toxicity An Organ Compartment Model of Lead
ted petroleum hydrocarbon [processing screening bioassay of [i 11 refineiy Biokinetics. (30-3 1647)

29
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 m 0732290 0 5 4 9 9 8 9 TOT m

Hunuin Exposure Assessment irritation study in rabbits. Dermal 83-07: Light catalytic cracked distillate.
sensitization study in guinea pigs. API (35-32432)
The Influence of Trace Metals in Disperse 83-19, light alkylate naphtha (CAS
Aerosols on the Human Body Burden of 64741-66-8). Final report. (33-30594) Toxicity Stidy
Trace Metals. (27-30840) Four-Week Oral Nephrotoxicity Screening
Study in Male F344 Rats [by Bomston A 28-Day Dermal Toxicity Study in the Rabbit
Toxicity S t i d y Laboratories Inc.]. Final Report. (32- of API [Sample] 83-07, a Light
30966) Catalytically Cracked Distillate (CAS
The Chronic Toxicity of Lead. (26-60096) Lifetime dermal carcinogenesis/chronic toxicity 64741-59-9). Final Report. (32-32751)
screening bioassay of [i i] refinery A (28--Day Dermal Toxicity Study in the
LEAD (REVIEW) streams in C3HMeJ mice. Twelve-month Rabbit. API [Sample] 83-08, Light
toxicity evaluation. (34-32865) Catalytically Cracked Distillate (CAS
Toxicity Study Lifetime dermal carcinogenesis/chronic toxicity 64741-59-9). (32-32753)
screening bioassay of refinery streams in Acute Oral Toxicity Study in Rats. Amte
A Review of the Toxicology of Lead (26- C3HMeJ mice. Three-month toxicity Dermal Toxicity Study in Rabbits.
60061) evaluation report. Final report. (33-32010) Primary Dermal Irritation Study in
Air Quality Standards for Lead. (26-60064) Twenty-four month dermal carcinogenesis/ Rabbits. Primary Eye Irritation Study in

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
chronic toxicity screening bioassay of Rabbits. Dermal Sensitization Study in
LEAD CHLOROBROMIDE refinery streams in C3HkieJ mice Guinea Pigs. API 83-08, Light
(AP-190r). Final Report. (36-33220) Catalytically Reformed Distillate (CAS
Toxicity Sfuày 64741 -59-9). (32-32859)
LIGHT CATALYTIC CRACKED Acute inhalation toxicity evaluation in rats: API
Study of Synergistic Effects of Cenain Airborne DISTILLATE 83-07. light catalytically cracked distillaie
Systems in the Cynomolgus Monkey. (27- (CAS 64741-59-9). Final report. (33-
30704) Carcinogenicity Study 30549)
Acute inhalation toxicity evaluation in rats: API
LIGHT ALKYLATE NAPHTHA Lifetime dermal carcinogenesis/chronic toxicity 83-08, light catalytically cracked distillate
screening bioassay of [il] refinery (CAS 64741-59-9). Final report. (33-
Carcinogenicity Study streams in C3H/HeJ mice. Twelve-month 30444)
toxicity evaluation. (34-32865) Acute oral toxicity study in rats. Acute dermal
Lifetime dermal carcinogenesis/chronictoxicity Lifetime dermal carcinogenesis/chronic toxicity toxicity study in rabbits. Primaiy dermal
screening bioassay of [ l i ] refinery screening bioassay of refinery streams in initation study in rabbits. Primary eye
streams in C3HMeJ mice. Twelve-month C3HMe.l mice. ?hree-month toxicity iniiaiion study in rabbits. Dermal
toxicity evaluation. (34-32865) evaluation report. Final report. (33-32010) sensitization study in guinea pigs. API
Lifetime dermal carcinogenesis/chronic toxicity Short-term dermal tumorigenesis study of selec- 83-07. light catalytically cracked distillate
screening bioassay of refinery streams in ted petroleum hydrocarbon [processing (CAS 64741-59-9). (33-30162)
C3II/Hel mice. Three-month toxicity fractions] in male CD-I mice. Initiation Lifetime dermal carcinogenesis/chronic toxicity
evaluation report. Final report. (33-32010) and promotion phases. (36-32643) screening bioassay of [li] refinery
Twenty-four month dermal carcinogenesis/ Twenty-four month dermal carcinogenesis/ streams in C3HMeJ mice. Twelvemonth
chronic toxicity screening bioassay of chronic toxicity screening bioassay of toxicity evaluation. (34-32865)
refinery streams in C3H/HeJ mice refinery streams in C3HMeJ mice Lifetime dermal carcinogenesis/chronic toxicity
(AP-190r). Final Report. (36-33220) (AP-190r). Final Report. (36-33220) screening bioassay of refinery streams in
C3HMeJ mice. Three-month toxicity
Mulagenicity Stuày Mutagenicity Study evaluation report. Final report. (33-32010)
Twenty-four month dermal carcinogenesis/
Acute In-Vivo Cytogenetics Assay in Male and Activity of API 83-08 (light catalytic cracked chronic toxicity screening bioassay of
Female Rais of API 83-19. Final Report. distillaie) in the acute in-vivo cytogenetics refinery streams in C3Hkie.l mice
(32-32409) assay in male and female rats. Final (AP-190r). Final Report. (36-33220)
L5178Y TIC+/- Mouse Lymphoma Mutagenesis report. (33-30493)
Assay of API [Sample] 83-19, Light Al- in vivo sister chromatid exchange assay with LIGHT CATALYTIC CRACKED
kylate Naphtha. Final Report. (32-32746) API 83-07 (light catalytic cracked NAPHTHA
distillate). (36-31429)
Toxicity Stidy L5178Y TK+/- Mouse Lymphoma Mutagenesis Carcinogenicity Study
Assay of API 83-08, [Light Catalytic
28day dermal toxicity study in the rabbit: API Cracked Distillate]. (32-31709) Lifetime Dermal CarcinogenesislChronic
83-19, light alkylate naphtha (CAS Mutagenicity Evaluation of API 83-07 in the Toxicity Screening Bioassay of Refmery
64741-66-8). Final report. (33-30498) Mouse Lymphoma Forward Mutation Streams in C3HMeJ Mice. Thm-Month
Acute inhalation toxicity evaluation of a Assay. Final Repons. (32-32167) Toxicity Evaluation Report. [Vol. 1-21,
petroleum-derived hydrocarbon in rats, Mutagenicity evaluation in the rat bone marrow (32-32653)
API 83-19, light alkylate naphtha (CAS cytogenetic assay. API 83-07. light Lifetime demiaì carcinogenesis bioassay of
64741-66-8). Final report. (34-30636) catalytically cracked distillate (CAS refinery streams in C3HMeJ mice
Acute oral toxicity study in rats. Acute dermal 64741-59-9). Final report. (33-30929) (AP-135R). (36-31364)
toxicity study in rabbits. Primary dermal Sister chromatid exchange assay in Chinese Lifetime demal carcinogenesis/chronic toxicity
irritation study in rabbits. Primary eye hamster ovary (CHO) cells with API screening bioassay of refinery streams in

30

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4b34 75 W 0 7 3 2 2 9 0 0 5 4 7 9 9 0 7 2 1

C3HRle-i mice. Twelvemonth toxicity naphtha (petroleum). (CAS 64741-55-5). Rabbits, and Primary Eye Irritation Study
evaluation report. Final report. [Vol. 1-31. (33-32722) in Rabbits of API 83-04 Light
(33-31 451) Dermal sensitization study in guinea pigs [by Catalytically Reformed Naphtha. (32-
Hazleton Laboratories America Inc.] :API 31473)
Mutagenicity Siudy 81-04 light catalytically cracked naphtha Dermal sensitization study in guinea pigs b y
(CAS 64741-55-5). Final report. (33- Hazleton Laboratories America Inc.] :API
Activity of API 81-04 in the Acute In-Vivo 30495) 83-04 light catalytically reformed naphtha
Cytogenetics Assay in Male and Female Four-Week Oral Nephrotoxicity Screening (CAS 64741-63-5). Final report. (33-
Rats. Final Report. (32-32288) Study in Male F344 Rats [by Borriston 30496)
In vivo sister chromatid exchange assay with Laboratories Inc.]. Final Report. (32- Four-Week Oral Nephrotoxicity Screening
API 81-03 (light catalytically cracked 30966) Study in Male F344 Rats [by Bomston
naphtha). Final report. (36-30044) LCso acute inhalation toxicity evaluation of a Laboratories Inc.]. Final Report. (32-
W178Y TK+/- Mouse Lymphoma Mutagenesis petroleum-derived hydrocarbon in rats. 30966)
Assay of API 81-04, [Light Catalytic API 81-03. light catalytically cracked Renal Toxicity of [Vapors of) Gasoline and
Cracked Naphtha] (32-31710) naphtha (CAS 64741-55-5). Final report. Related Petroleum Naphthas in Maie Rats.
Mutagenicity Evaluation Studies in the Rat (33-31902) (32-304 14)
Bone Marrow Cytogenetic Assay [and] in Lifetime Demial Carcinogenesis/Chronic
the Mouse Lymphoma Forward Mutation Toxicity Screening Bioassay of Refinery LIGHT PARAFFINIC DISTILLATE
Assay of Light Catalytically Cracked Streams in C3H/HeJ Mice. Three-Month
Naphtha. [API] Sample 81-03. Final Toxicity Evaluation Report. [Vol. 1-21, Carcinogeniciry Siudy
Report. (32-31300) (32-32653)
Mutagenicity of API 83-20. light catalytic Lifetime dermal carcinogenesis bioassay of Lifetime dermal carcinogenesis/chronic toxicity
cracked naphtha (CAS 64741-55-5) in a refinery streams in C3HflieJ mice screening bioassay of [ l i ] refinery
niouse lymphoma mutation assay. Final (AP-135R). (36-3 1364) streams in C3H/HeJ mice. Twelve-month
report. (34-30633) Lifetime dermal carcinogenesis/chronic toxicity toxicity evaluation. (34-32865)
Sister chromatid exchange assay in Chinese screening bioassay of refinery streams in Lifetime dermal carcinogenesis/chronic toxicity
hamster ovary (CHO) cells with API C3H/HeJ mice. Twelve-month toxicity screening bioassay of refinery streams in
81-03 [(light catalytically cracked evaluation report. Final report. [Vol. 1-31, C3HMe.J mice. Three-month toxicity
naphtha)]. Final report. (36-30045) (33 -31451) evaluation report. Final report. (33-32010)
Renal Toxicity of [Vapors of) Gasoline and Short-term dermal tumorigenesis study of selec-
Toxicity Siirdy Related Petroleum Naphthas in Maie Rats. ted petroleum hydrocarbon [processing
(32-304 14) fractions] in male CD-I mice. Initiation
28-Day dermal toxicity study in the rabbit [by Thirteen-week subchronic inhalation toxicity and promotion phases. (36-32643)
Tegeris Laboratories Inc.]. API 81-04, study in rats with API 81-03: Light Twenty-four month dermal carcinogenesis/
light Catalytically cracked naphtha (CAS catalytic cracked naphtha (CAS chronic toxicity screening bioassay of
64741-55-5). Final report. (33-30747) 64741-55-5). (34-33173) refinery streams in C3H/HeJ mice
A (28--Day demial toxicity study of API 83-20 (AP-190r). Final Repon. (36-33220)

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
[clear liquid test article] in the rabbit. (37- LIGHT CATALYTIC REFORMED
31958) NAPHTHA Murageriici9 Siiidy
A Demial Sensitization Study [by Hazleton
Laboratories America lnc.] in [SO] Guinea Muiageniciry Siiidy Mutagenicity of API 84-01. light paraffinic
Pigs [by the] Closed Patch Technique distillate (CAS 64741-50-0). in a mouse
[with the Use of) API Sample 81-03. (31- Mutagenicity Evaluation of API #83-O4 in the lymphoma mutation assay. Final report.
31412) Mouse Lymphoma Forward Mutation (33-32801)
Acute Inhalation Toxicity Evaluation of a Assay. Final Report. (32-32168)
Petroleum-Derived Hydrocarbon in Mutagenicity evaluation in the rat bone marrow Toxicity 9 i d y
Rats...Light Catalytic Cracked Naphtha. cytogenetic assay. API 83-04, light
API Sample 81-04. (31-30680) catalytically reformed naphtha (CAS Acute oral toxicity study in rats. Acute dermal
Acute Oral Toxicity Study i n Rats. Acute 64741-63-5). Final report [by Litton toxicity study in rabbits. Primary dermal
Dermal Toxicity Study in Rabbits. Bionetics Inc.]. (33-31092) irritation study in rabbits. Primary eye
Primary Dermal Irritation Study in irritation study in rabbits. Dermal
Rabbits, [and] Primary Eye Irritation Toxicity Sruày sensitization study in guinea pigs. API
Study in Rabbits of API 81-04, Light 84-01. light paraffinic distillate (CAS
Catalytically Cracked Naphtha. (32-31708) 28-Day dermal toxicity study in the rabbit [by 64741-50-0). Final report. (33-30595)
Acute inhalation toxicity evaluation of a Tegeris Laboratories Inc.]. API 83-04. .¡fetime demial carcinogenesis/chronic toxicity
petroleum-derived hydrocarbon in rats. light catalytically reformed naphtha (CAS screening bioassay of [ l i ] refinery
AP1 83-20: Light catalytic cracked 64741-63-5). Final report. (33-30597) streams in C3H/HeJ mice. Twelve-month
naphtha (CAS 64741-55-55). (34-32777) Acute Inhalation Toxicity Evaluation of a toxicity evaluation. (34-32865)
Acute oral toxicity study in rats. Acute dermal Petroleum-Derived Hydrocarbon in Rats. .¡fetime dermal carcinogenesis/chronic toxicity
toxicity study in rabbits. Primary dermal Light Catalytic Reformed Naphtha...API screening bioassay of refinery streams in
imtation study in rabbits. Primary eye Sample 83-04. (31-30613) C3H/HeJ mice. Three-month toxicity
imiation study in rabbits. Dermal Acute Oral Toxicity Study in Rats, Acute evaluation repon. Final report. (33-32010)
sensitization study in guinea pigs. Final Dermal Toxicity Study in Rabbits, Short-term dermal tumorigenesis study of selec-
report. API 83-20. light catalytic cracked Primary Dermal Irritation Study in ted petroleum hydrocarbon [processing

31

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 0732290 0549993

fractions] in male CD-I mice. Initiation LIGHT STRAIGHT RUN NAPHTHA MTBE (REVIEW)
and promotion phases. (36-32643)
Twenty-eightday dermal toxicity study in the Toxicity Strcdy Odor and Taste
rabbit. API 84-01, light paraffinic distillate
(CAS 64741-50-0). Final report [by Renal Toxicity of [Vapors ofl Gasoline and [A literature] review of published odor
Tegens Laboratories Inc.]. (33-31642) Related Petroleum Naphthas in Male Rats. [threshold values (OTVs)] and taste
Twenty-four month dermal carcinogenesis/ (32-30414) threshold values [ m s ) ] of [the (2761
chronic toxicity screening bioassay of soluble gasoline components (33-30589)
refinery streams in C3Hme.l mice
(AP-190r). Final Report. (36-33220) LITHIUM (REVIEW) MANGANESE (REVIEW)

Toxicity Study Toxiciiy Study


L I G H T PARAFFINIC DISTILLATE
SOLVENTEXTRACT Lithium. (26-60067) Manganese. (26-60114)

Carcinogenicity Study MERCURY (REVIEW)


LUBRICANT BASE OILS (REVIEW)
Lifetime dermal carcinogenesis/chronic toxicity Toxicity Study
screening bioassay of [ i l ] refinery Carcinogenicity Study
streams in C3H/HeJ mice. Twelve-month Cadmium, Zinc, and Mercury. (26-60115)
toxicity evaluation. (34-32865) Toxicological Characteristics of Refinery
Lifetime dermal carcinogenesis/chronic toxicity Streams Used To Manufacture Lubricating METABOLISM/I”ARMACOKINFICS
screening bioassay of refinery streams in Oils. (31-02438)
C3HkIe.I mice. ?hree-month toxicity Dermal
evaluation report. Final report. (33-32010) MTBE
Twenty-four month dermal carcinogenesis/ Absorption of petroleum products across the
chronic toxicity screening bioassay of Developmental Effects skin of monkey and man. Final report.
refinery streams in C3HMeJ mice (37-31 827)
(AP-190r). Final Report. (36-33220) A Single-Generation Inhalation Reproduction/ Absorption of petroleum products across the
Fertility Study in Rats with Methyl t-Butyl skin of the monkey and miniature pig.
Ether (MTBE). (32-30239) Annual report (Mar. 15, 1979-Mar. 14,
Mirragenicity Study A teratology evaluation of methyl tertiary butyl 1980). (33-31034)
ether in rats and mice (33-31095) Disposition and pharmacokinetics of c a n -
Mutagenicity of API 83-16, light paraffinic An Inhalation Teratology Study in Mice with mercial hexane following IV bolus,
distillate solvent extract (petroleum) (CAS Methyl t-Butyl Ether (MTBE). (32-30237) dermal absorption or nose-only
64742-05-8). in a mouse lymphoma An Inhalation Teratology Study in Rats with inhalation ...Final report. (39-33107)
mutation assay. Final report. (33-32803) Methyl i-Butyl Ether (MTBE). (32-30236) Percutaneous Absorption of Benzene (30-
3 1994)
Odor and Taste The Absorption of Petroleum Products a c m s
Toxicity Struiy the Skin of Monkey and Man: Annual
Odor threshold studies performed with gasoline Report, Jan. i , 1984 to Dec. (31-, 1984.
28-Day dermal toxicity study in the rabbit. API and gasoline combined with MTBE, (32-32749)
83-16. light paraffinic distillate solvent ETBE. and TAME. (41-01257) The Induction of Xenobiotic Metabolism in
extract (CAS 64742-05-8). Final report Rats on Exposure to Hydrocarbon-Based
[by Tegeris Laboratories inc.]. (33-31695) MeíabolismlPharmacokinetics Oils. (30-31995)
Acute oral toxicity study in rats. Acute dermal [in-vitro measurements of the] penetration of
toxicity study in rabbits. Primary demal The Metabolic Fate of Methyl t-Butyl Ether benzene through human [abdominal] skin
irritation study in rabbits. Primary eye ( M T B E ) F o l l o w i n g an A c u t e (33 -31225)
irritation study in rabbits. Dermal Intraperitoneal Injection. (32-30238)
sensitization study in guinea pigs. API
83-16, light paraffinic distillate solvent Reproductive Effecrs
extract (CAS 154742-05-8). (33-31226) Benzene pharmacokinetics and
Lifetime dermal carcinogenesis/chronic toxicity A Single-Generation Inhalation Reproduction/ pharmacodynamics. (36-3 1431)
screening bioassay of [ i l ] refinery Fertility Study in Rats with Methyl i-Butyl Disposition and pharmacokinetics of com-
streams in C3HmeJ mice. Twelve-month Ether (MTBE). (32-30239) mercial hexane following IV bolus,
toxicity evaluation. (34-32865) Methyl tertiary butyl ether inhalation in rats: A dermal absorption or nose-only
Lifetime dermai carcinogenesis/chronic toxicity single generation reproduction study. (35- inhalation ...Final report. (39-33107)
screening bioassay of refinery streams in 30687) Studies on the absorption, tissue equilibria and
C3Hme.l mice. ?hree-month toxicity excretion routes of inhaled hydrocarbon
evaluation report. Final report. (33-32010) Toxicity Sir&? vapors and their metabolites (36-31430)
Twenty-four month dermal carcinogenesis/ Studies on the absorption of inhaled hydro-
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

chronic toxicity screening bioassay of A Nine Day Inhalation Toxicity Study of carbon vapors. Final report. (34-33036)
refinery streams in C3IUHeJ mice Methyl 1-Butyl Ether in the Rat. (32- [Studies of the] Absorption, Distribution, and
(AP-190r). Final Report. (36-33220) 30235) Excretion of Ethylbenzene,

32

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 I0 7 3 2 2 9 0 05Li9992 5 T 4 I

Ethylcyclohexane, and Methylethyl- Toxicity Study METHYL ISOBUTYL KETONE


benzene Isomers in Rats (27-31528)
Clinical toxicology of the acute ingestion of Toxicity Study
inrraperitoneal methanol/hydrocarbon blends. A
state-of-the-art review. (39-3 1093) The Myocardial Toxicity [to Dogs] of Selected
The Metabolic Fate of Methyl t-Butyl Ether Methanol health effects. Epidemiology literature Aliphatic Hydrocarbons, [Including
( M T B E ) F o l l o w i n g an A c u t e review and search for study population--i. Propane (P), n-Butane, Isobutane. and a
Intraperitoneal Injection. (32-30238) Critical review of the literature. 2. Search Mixture of These Hydrocarbons (A-46).
for study population. (39-31095) and Mixtures of Isobutane with Methyl
Study of the relationship between folate status Chloroform, Trichloroethylene. Methyl
intravenous and methanol toxicity. (41-30101) Ethyl Ketone, and Methyl Isobutyl
Ketone]. (30-32013)
Disposition and pharmacokinetics of commer- METHYL BUTYL KETONE (REVIEW)
cial hexane following IV bolus. dermal 2-METHYLBUTANE
absorption or nose-only inhalation...Final Nerrrotoxicity Study

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
report. (39-33 107) Toxicity Study
The Absorption of Petroleum Products across Neurotoxicity of organic solvents with special
the Skin of Monkey and Man: Annual reference to the neurobehaviorai effects: A Four-Week Oral Nephrotoxicity Screening
Report. Jan. 1, 1984 to Dec. (31-. 1984. [world] literature review (39-30623) Study in Male F344 Rats [by Bomston
(32-32749) Laboratories Inc.]. Final Report. (32-
METHYL n-BUTYL KETONE 30966)
Oral
Neuroroxiciry Sruày METHY LCY CLOPENTANE
Metabolic Model of Lead Kinetics Based upon
Measured Organic Burdens during Experimental Studies of Hexacarbon Meia bolisnilPharmorokinerics
Chronic Exposure Experiments with [66] Neurotoxicity. Final Repoii. (29-32291)
Infant and Juvenile Baboons. (31-30264) Disposition and pharmacokinetics of com-
An Organ Compartment Model of Lead mercial hexane following IV bolus,
Biokinetics. (30-31647) METHYL CHLORIDE (REVIEW) dermal absorption o r nose-only
inhalation ...Final repoa. (39-33 107)
Neuroroxiciiy Sriuly Studies on the absorption of inhaled hydro-
Review carbon vapors. Final report. (34-33036)
Neurophysiological and Psychological Disorders
Benzene Toxicity. A Critical Evaluation (26- and Occupational Exposure to Organic Toxicity Study
60074) Solvents. (31 -32980)
Polycyclic Aromatic Hydrocarbons [(PAHs)] : Four-Week Oral Nephrotoxicity Screening
A Review (28-30174) METHYL CHLOROFORM Study in Male F344 Rats [by Bomston
The Effects of n-Hexane in Man and Animals. Laboratories Inc.]. Final Report. (32-
(30-31603) Toxirip Srirdy 30966)
[A Review ofl Benzene Metabolism (26-60076)
The Myocardial Toxicity [to Dogs] of Selected 2-METHY LDECANE
Aliphatic Hydrocarbons, [Including
METHANOL Propane (P), n-Butane. Isobutane, and a Toxicity Siudy
Mixture of These Hydrocarbons (A-46).
Hitman Expsiire Assessnieni and Mixtures of Isobutane with Methyl Final Report. A four-week oral nephrotoxicity
Chloroform, Trichloroethylene, Methyl screening study in male E344 rats (33-
Acute exposure to methanol in fuels: A Ethyl Ketone, and Mdhyl Isobutyl 31097)
prediction of ingestion incidence and Ketone]. (30-32013)
toxicity. (36-3 1914)
METHYLENE CHLORIDE (REVIEW)
METHYL ETHYL KETONE
METHANOL (REVIEW) Neiiroroxicity Srudy
Toxirip: Sruày
Neuroroxicity Sruày Neurotoxicity of organic solvents with special
The Inhalation Toxicity of n-Hexane and reference to the neurobehaviorai effects: A
Neurotoxicity of organic solvents with special Methyl Ethyl Ketone. (30-32005) [world] literature review (39-30623)
reference to the neurobehavioral effects: A The Myocardial Toxicity [to Dogs] of Selected
[world] literature review. (39-30623) Aliphatic Hydrocarbons. [Including METHYLENE DICHLORIDE (REVIEW)
Propane (P), n-Butane, Isobutane, and a
Odor and Taste Mixture of These Hydrocarbons (A-46). Neuroroxicity Srudy
and Mixtures of Isobutane with Methyl
[A literature] review of published odor and taste Chloroform, Trichloroethylene, Methyl Neurophysiological and Psychological Disorders
threshold values of [the (2761 soluble Ethyl Ketone. and Methyl Isobutyl and Occupational Exposure to Organic
gasoline components. (33-30589) Ketone]. (30-32013) Solvents. (31 -32980)

33

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLmYb34 95 = 0732290 0549973 430 =

METHYLETHYLBENZENE Toxicity Evaluation Report. [Vol. 1 and C3HMeJ mice. Twelve-month toxicity
2). (32-3263) evaluation report. Final report. [Vol. 1-31,
MetabolismlPharmacokinerics Lifetime dermal carcinogenesis/chronic toxicity (33 -31451)
screening bioassay of refinery streams in Short-term dermal tumorigenesis study of selec-
[Studies of the] Absorption, Distribution, and C3H/HeJ mice. Twelve-month toxicity ted petroleum h y d m a h [processing
Excreiion of Ethylbenzene, Ethylcyclo- evaluation report. Final report. [Vol. 1-31. fractions] in male CD-1 mice. Initiation
hexane, and Methylethylbenzene Isomers (33-31451) and promotion phases. (36-32643)
in Rats (27-31528) The Carcinogenic Potential of Key Petroleum The Carcinogenic Potential of Key Petroleum

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Products. (30-31646) Products (30-31646)
2-METHYLHEXANE
Toxicity Study Toxicity Study
Toxicity Study
Lifeïime Dermal Carcinogenesis/Chronic Lifetime Dermal Carcinogenesis/Chronic
Four-Week Oral Nephrotoxicity Screening Toxicity Screening Bioassay of Refinery Toxicity Screening Bioassay of Refinery
Study in Male F344 Rats [by Bomston Streams in C3H/HeJ Mice. Three-Month Streams in C3HMeJ Mice. Three-Month
Laboratories Inc.]. Final Report. (32- Toxicity Evaluation Report. [Vol. 1-21, Toxicity Evaluation Repon. [Vol. 1-21.
30966) (32-32653) (32-32653)
Lifetime dermal carcinogenesislchronic toxicity Lifetime dermal carcinogenesislchronic toxicity
1-METHYLNAPHTHALENE screening bioassay of refinery streams in screening bioassay of refinery streams in
C3H/HeJ mice. Twelve-month toxicity C3H/HeJ mice. Twelve-month toxicity
Aquatic Toxicity evaluation report. Final report. [Vol. 1-3). evaluation report. Final report. [Vol. 1-31.
(33-31451) (33-31451)
The Effects of Oil on Estuarine Animals:
Toxicity, Uptake and Depuration. MIDDLE DISTILLATE (30% CC SïOCK) MINERAL OIL
Respiration. (26-6Cû30)
Curcinogenicity Sfudy Muiugenicity Study
3-METHY LOCTANE
Lifetime Dermal Carcinogenesis/Chronic Mutagenicity Evaluation of Six Petroleum
Taricity Study Toxicity Screening Bioassay of Refinery Substances in an In-Vivofln-Vitro Urine
Streams in C3HRIeJ Mice. Three-Month Assay. (30-31037)
Final Report. A four-week oral nephrotoxicity Toxicity Evaluation Report. [Vol. 1-21,
screening study in male F344 rats (33- (32-32653) Toxicity Sridy
31097) Lifetime dermal carcinogenesis/chronic toxicity
screening bioassay of refinery streams in A 90-day feeding study in the rat with six
2-METHYLPENTANE C3HMeJ niice. Twelve-month toxicity different white minerai oils (N15 (H),N70
evaluation repon. Final report. [Vol. 1-31. (HI. N70 (A). PI5 (H), N10 (A), and
(33-31451) P100 (H),three different mineral waxes (a
The Carcinogenic Potential of Key Petroleum low-melting-point wax. a high-meiting-
Studies on the absorption of inhaled hydro- Products (30-3 1646) point wax, and a high-sulphur wax) and
carbon vapors. Final report. (34-33036) COConUt Oil. July 1992. (39-32387)
Toxicity Stidy
Toxicity Study
Lifetime Dermal CarcinogenesislChronic MINERAL OIL (REVIEW)
Four-Week Oral Nephrotoxicity Screening Toxicity Screening Bioassay of Refinery
Study in Male F344 Rats [by Bomston Streams in C3HMeJ Mice. Three-Month Toxicity S i i d y
Laboratories Inc.]. Final Report. (32- Toxicity Evaluation Report. [Vol. 1-21,
30966) (32-32653) API Mineral Oil Review. (39-31651)
Lifetime dermal carcinogenesis/chronic toxicity
2-METHY L-2-PENTENE screening bioassay of refinery streams in
C3HMeJ mice. Twelve-month toxicity MINERAL SEAL OIL (REVIEW)
Toxicity Study evaluation report. Final report. [Vol. 1-31.
(33-31451) Toxicity Sirdy
Four-Week Oral Nephrotoxicity Screening
Study in Male F344 Rats [by B O I T ~ S I ~ ~MIDDLE DISTILLATE (50% C C SI'OCK) Clinical toxicology of the acute ingestion of
Laboratories Inc.]. Final Report. (32- methanol/hydrocarbon blends. A
30966) Carcinogenicity Str<dv state-of-the-art review. (39-31093)

MIDDLE DISTILLATE (10% C C S r O C K ) Lifetime Dennal Carcinogenesis/Chronic MINERAL SPIRITS (REVIEW)


Toxicity Screening Bioassay of Refinery
Carcinogenicity Sr& Streams in C3HMeJ Mice. Three-Month Toxicity Study
Toxicity Evaluation Report. [Vol. 1-21.
Lifetime Dermal Carcinogenesis/Chronic (32-32653) Clinical toxicology of the acute ingestion of
Toxicity Screening Bioassay of Refinery Lifetime dermal carcinogenesis/chronic toxicity methanol/hydrocarbon blends. A
Streams in C3H/HeJ Mice. Three-Month screening bioassay of refinery streams in state-of-the-art review. (39-31093)

34

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLX4634 95 0732290 0547774 377

MINERAL TURPENTINE (REVIEW) MOTOR OIL COMPOSITE - USED Coke. Liquid 7-1-100. A Revised Final
Report. (28-30725)
Toxicity Study Carcinogenicity Study In-Vivo and In-Vitro Mutagenicity Studies.
Solid Condensed Emission Product from
A Review of the Human Kidney Effects of The Carcinogenicity of New and Used Delayed Coke Process. (Petroleum Coking
Hydrocarbon Exposure (32-30410) Lubricants. (30-32847) Sample 3-1-134). (28-30727)
Mutagenic Evaluation of 60 Solvent
(CHF-33-148). (26-60003)
MODELING Mutagenic Evaluation of Filtered Rubber
Solvent (CHF-32-263). (26-60016)
[Project No. 14431 Acute Toxicity Tests. API Mutagenic Evaluation of Rubber Solvent
79-7 Used Composite Motor Oil. (27- (CHF-32-263). (26-6001 1)
An Organ Conipartment Model of Lead 32772) Mutagenicity Evaluation of Benzene ...Final
Biokinetics. (30-3 1647) Report. (26-60092)
Mutagenicity Evaluation of Diesel Fuel. (26-
MUTAGENICITY S U D Y 60102)
MOLYBDENUM (REVIEW) Mutagenicity Evaluation of Kerosene. Final
Report. (2660017)
Toxicity Study Ames test Mutagenicity Evaluation of Petroleum Hydro-
carbons. (30-31997)
Chromium. (26-601 13) Adapting the Ames Salmonella Assay to Mutagenicity Evaluation of Raw Shale. Final
Complex Hydrocarbon Mixtures. Final Report. (26-60044)
Report. (32-32856) Mutagenicity Evaluation of Retorted Shale.
MOTOR OIL NEW - Estimation of the Mutagenicity of Hydrocarbon Final Report. (2660006)
Fractions Utilizing the Bacterial Assay Mutagenicity Evaluation of Six Petroleum
ToxicifyStudy Procedure with Mammalian Tissue Meta- Substances in an In-Vivofln-Vitro Urine
bolic Activation. API Project PS-4 #6. Assay. (30-31037)
The Acute Toxicology of Selected Petroleum (26-60103) Mutagenicity Evaluation of Stoddard [Solvent]
Hydrocarbons. (30-3 1530) Evaluation of Techniques for Mutagenicity "Fuel". (26-60010)
Screening of Petroleum Hydrocarbons. Mutagenicity Evaluation of Toluene. (26-60020)
MOTOR OIL - USED (30-31588) Mutagenicity Evaluation of Unleaded Gasoline:
In-Vit ro and In-Vivo Mutagenicity Studies. Jet Final Report. (28-30173)
Fuel A. Final Report. (27-30051) Mutagenicity Evaluation of Xylene. (26-60018)
In-Vitro and In-Vivo Mutagenicity Studies. Mutagenicity Evaluation of waw Shale]
The Induction of Xenobiotic Metabolism in New Oil Composite [Motor Oil]. Final RS-101. Final Report. (26-60021)
Rats on Exposure to Hydrocarbon-Based Report. (27-00325) Mutagenicity Evaluation of [Shale Oil] R-01.
Oils. (30-31995) In-Vitro and In-Vivo Mutagenicity Studies. No. Draft Report. (26-60004)
2 Home Heating Oil. Final Report. (27- Mutagenicity Evaluation of [Shale Oil] R-03.
Toxicity Stiuiy 30140) Draft Report. (2660005)
In-Vivo and In-Vitro Mutagenicity Studies. Mutagenicity Evaluation of [Shale Oil] R-04.
The Acute Toxicology of Selected Petroleum Delayed Process Coke. (Petroleum Coking (26-60009)
Hydrocarbons. (30-31530) Sample 4-1-140). A Revised Final Repon. Mutagenicity of Automotive Particulate
(28-30728) Exhaust. The Influence of Fuel Extenders,
In-Vivo and In-Vitro Mutagenicity Studies. Additives. and Aromatic Content (30-
MOTOR OIL COMPOSITE NEW - Fluid Process Coke. (Petroleum Coking 31998)
Sample 6-1-468). A Revised Final Report. Mumgenicity test on ASTM D-3734 Type 1 C,
Carcinogenicity Srridy (28-30726) in the Ames Salmunella/microsome
in-Vivo and In-Vitro Mutagenicity Studies. reverse mutation assay. Final report. (35-
The Carcinogenicity of New and Used Paraffinic Oil 78-10, 150 SUS/lOO "F. 30932)
Lubricants. (30-32847) Final Repon. (28-31868) Polynuclear aromatic analyses and modified
In-Vivo and In-Vitro Mutagenicity Studies. Ames tests on base lube [lubricating]
Mutagenicity Stua'j Paraffinic Oil 78-9,70 SUS/I00 "F. Final stocks. (36-33219)
Report. (28-31864) Salmonella/mammalian-microsome plate
in-Vitro and In-Vivo Mutagenicity Studies. In-Vivo and In-Vitro Mutagenicity Studies. incorporation mutagenicity assay (Ames
New Oil Composite [Motor Oil]. Final Paraffinic Oil 79-3, 350 SUS/ICû OF. test). Final report. (33-30599)
Report. (27-00325) Final Report. (28-3 1865) The mutagenic potential of high flash aromatic
Mutagenicity Evaluation of Petroleum Hydro- In-Vivo and In-Vitro Mutagenicity Studies. naphtha. (36-33132)
carbons. (30-31997) Paraffinic Oil 79-4. 550 SUS/100 "F. Use of the Ames Assay To Detect Diumal
Final Report. (28-31866) Variations in Fractions of Extracted
Toxicity Study In-Vivo and In-Vitro Mutagenicity Studies. Pañiculaie Organic Matter. (29-32827)
Paraffinic Oil 79-5. 800 SUS/100 OF. SaImo~~ella/mammalian-microsane mutagenicity
[Project No. 14431 /Acute Toxicity Tesis [ofj Final Report. (28-31867) assay of the vapor phase of commercial
APl #78-i, New Composite Motor Oil. In-Vivo and In-Vitro Mutagenicity Studies. hexane using the desiccator methodology.
(27-32 131) Quench Water from Delayed Process (36-32641)

35
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLW4b34 95 0 7 3 2 2 9 0 0 5 4 9 9 9 5 203

Cell iratuformaiion assay Benzene in Rats [and Effects on Male Microtudei frequency
Reproductive Perfomance]. (28-3121 1)
Final Report: Testing of API Petroleum [Final Report on the] Mutagenicity Evaluation Evaluation of Micronuclei [(MN)] Frequency in
Fractions for Genotoxicity in C3H/iOTiR of n-Hexane in the Mouse Dominant the Peripheral Blood of Male and Female
Cells. (30-31038) Lethal Assay. (27-32179) CD-1 Mice Exposed Chemically to
Morphological transformation of BALB/3T3 [Litton Bionetics Inc. Project No. 21 141-021 Benzene for 90 Days. Final Report. (32-
mouse embryo cells. API 81-15, /Mutagenicity Evaluation of Gasoline, API 32855)
catalytically cracked clarified oil (CAS PS-6 Fuel (Unleaded) in the Mouse
64741-62-4). Final report [by Micro- Dominant Lethal Assay. Final Report. (28- Mouse embryo limb bud

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
biological Associates Inc.]. (33-32638) 3 1344)
Morphological transformation of BALB/3T3 [Litton Bionetics Inc. Project No. 21141-031 Evaluation of API 81-15 (catalytic cracked
mouse embryo cells. API PS-8-76C2. /Mutagenicity Evaluation of Jet Fuel A in clarified oil) in the in-vitro assay for
Final report. (34-30859) the Mouse Dominant Lethal Assay. Final chemical teratogenic potential: inhibition
Morphological transformation of BALBDT3 Report. (28-31345) of proteoglycan synthesis. Final report.
mouse embryo cells. API PS-8-76D5 [Litton Bionetics Inc. Project No. 21141-041 (35-31938)
ARO. Final report. (34-30858) /Mutagenicity Evaluation of Diesel Fuel in Evaluation of API 86-02 (solvent refined coal
the Mouse Dominant Lethal Assay. Final distillate) in the in-vitro assay for
CHOIHGPRT mutalion assay Report. (28-31346) chernical teratogenic potential: Inhibition
[Litton Bionetics Inc. Project No. 21141-051 of proteoglycan synthesis. Final report.
CHO [(Chinese Hamster Ovary)] MGPRT /Mutagenicity Evaluation of Toluene in (35-31 936)
[(Hypoxanthine-Guanine Phosphoribosyl the Mouse Daninant Lethal Assay. Final Evaluation of benzo(a)pyrene in the in-vitro
Transferase)] Mammalian Cell Forward Report. (28-31347) assay for chemical teratogenic poiential:
Gene Mutation Assay of API [Sample] Inhibition of proteoglycan synthesis. Final
RO-i Retorted Shale Oil. Final Report. HEPM cell growth inhibition assay =port. (35-31937)
(32-32744) Evaluation of toluene in the in-viir0 assay for
CHO [(Chinese hamster ovary)]/HGPRï muta- Human embryonic palatal mesenchyme chemical teratogenic potential: Inhibition
tion assay of commercial hexane, Final (HEPM) cell growth inhibition assay [of of proteoglycan synthesis. Final report.
Repoii. (37-31487) API-81-15 (catalytic cracked clarified (35-31939)
CHOIHGPRT [(Chinese Hamster Ovary/ Hypo- oil)]...S-9 mediated assay (36-31910)
xanthine-Guanine Phosphoribosyl Trans- Human embryonic palatal mesenchyme Morue lymphoma mutation assay
ferase)] Mammalian Cell Forward Gene (HEPM) cell growth inhibition assay [of
Mutation Assay of API 81 -15. (32-321 18) API-86-02 (a dark viscous petroleum An L5178Y TK+/-Mouse Lymphoma Muta-
Mutagenicity test on ASTM D-3734 Type I C, liquid)] (36-3191 1) genesis Assay of API 83-11 [(Straight
in the CHOIHGPRT [(Chinese hamster Human embryonic palatal mesenchyme Run Middle Distillate) by Microbiological
ovaryhypoxanthine-guanine phosphon- (HEPM) cell growth inhibition assay [of Associates Inc.] (32-31768)
bosyl transferase)] forward mutation API-86-02 (a dark viscous petroleum In-Vitro and In-Vivo Mutagenicity Studies. Jet
suspension assay. Final Report. (35- liquid)] ...S-9 mediated assay (36-31912) Fuel A. Final Report. (27-30051)
30935) Human embtyonic palatal mesenchyme In-Vitro and In-Vivo Mutagenicity Studies.
The mutagenic potential of high flash aromatic (HEPM) cell growth inhibition assay [of New Oil Composite [Motor Oil]. Final
naphtha. (36-33132) BaP] (36-31913) Report. (27-00325)
Human embryonic palatal mesenchyme In-Vitro and In-Vivo Mutagenicity Studies. No.
Chromosomal aberrarions (HEPM) cell growth inhibition assay [of 2 Home Heating Oil. Final Report. (27-
BaP] (36-31913) 30140)
Chromosome aberrations in Chinese hamster Human embryonic palatal mesenchyme In-Vivo and In-Vitro Mutagenicity Studies.
ovary (CHO) cells exposed to commercial (HEPM) cell growth inhibition assay [with Delayed Process Coke. (Petroleum Coking
hexane (37-31152) toluene] ...Final report. (37-30618) Sanipie 4-1-140). A Revised Final Report.
Mutagenicity test on ASTM D-3734 Type I C, Human embryonic palatal mesenchyme (28-30728)
in an in vitro cytogenetic assay measuring (HEPM) cell growth inhibition assay ...S-9 In-Vivo and In-Vitro Mutagenicity Studies.
c h m o s o m a l aberration frequencies in mediated assay [with benzo(a)pyrene Fluid Process Coke. (Petroleum Coking
Chinese hamster ovary (CHO) cells. Final (BaP)]...Final report. (37-30619) Sample 6-1-468). A Revised Final Report.
report. (35-30934) Human embryonic palatal mesenchyme (28-30726)
(HEPM) cell growth inhibition assay ...S-9 In-Vivo and In-Vitro Mutagenicity Studies.
Dominant lerhal assay mediated assay [with toluene] ... Final Paraffinic Oil 78-10, 150 SUS/100 OF.
report. (37-30620) Final Report. (28-31868)
Mutagenic Evaluation of 60 Solvent The human embryonic palatal mesenchyme In-Vivo and In-Vitro Mutagenicity Studies.
(CHF-33-148). (26-60003) (HEPM) cell growth inhibition assay [of Paraffinic Oil 78-9, 70 SUS/100 OF. Final
Mutagenic Evaluation of Filtered Rubber AP1-81-15 (catalytic cracked clarified oil)] Report. (28-31864)
Solvent (CHF-32-263). (26-60016) (36-31909) In-Vivo and In-Vitro Mutagenicity Studies.
Mutagenic Evaluation of Rubber Solvent Paraffinic Oil 79-3, 350 SUS/100 "F.
(CHF-32-263). (26-6001 1) In virro Final Report. (28-31865)
Mutagenicity Study of Thirteen Petroleum In-Vivo and In-Vitro Mutagenicity Studies.
Fractions. (26-60098) Characterization of the Effecis of Beta- Paraffinic Oil 79-4. 550 SUS/100 "F.
[Bio/dynamics Inc. Project No. 79-73421 /A Propiolactone and Anthralin on Trans- Final Report. (28-31866)
Dominant-Lethal Inhalation Study with formation of BALBnT3 Cells. (29-32681) In-Vivo and In-Vitro Mutagenicity Studies.

36

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL84634 95 m 0732290 0549996 L 4 T m

Paraffinic Oil 79-5, 800 SUS/I00 'F. 81-13. (31-30614) assay. API 81-10, hydrodesulfunzed
Final Report. (28-31867) Mutagenicity Evaluation Studies in the Rat middle distillate (CAS 64742-80-9). Final
In-Vivo and In-Vitro Mutagenicity Studies. Bone Marrow Cytogenetic Assay and in report. (33-31224)
Quench Water from Delayed Process the Mouse Lymphoma Forward Mutation Mutagenicity of API 81-10 ARO, aromatic
Coke. Liquid 7-1-100. A Revised Final Assay. Hydrodesulfunzed Middle fraction of hydrodesulfurized middle
Report. (28-30725) Distillate, API Sample 81-09. Final distillate (CAS 64742-80-9) (coded as API
In-Vivo and In-Vitro Mutagenicity Studies. Report. (32-30965) 86-10 ARO) in a mouse lymphoma
Solid Condensed Emission Product from Mutagenicity Evaluation Studies in the Rat mutation assay. Final report. (34-32644)
Delayed Coke Process. (Petroleum Coking Bone Marrow Cytogenetic Assay and in Mutagenicity of API 81-10 SAT, saturated
Sample 3-1-134). (28-30727) the Mouse Lymphoma Forward Mutation fraction of hydrodesulfunzed middle
In-Vivo and In-Vitro Mutagenicity Studies. Assay. Vacuum Residu um...API Sample distillate (CAS 64742-80-9) (coded as API
n-Hexane (Hexane UV). Final Report. 81-14. (31-30615) 86-10 SAT) in a mouse lymphoma
(28-31628) Mutagenicity Evaluation in the Mouse Lym- mutation assay. Final report. (34-32645)
L5178Y TK+/- Mouse Lymphoma Mutagenesis phoma Forward Mutation Assay, API Mutagenicity of API 81-10. hydrodesulfurized
Assay of API 81-04. [Light Catalytic #83-06. Heavy Catalytically Reformed middle distillate (CAS 64742-80-9) (coded
Cracked Naphtha] (32-31710) Naphtha. Final Report. (32-32460) as APl 86-10) in a mouse lymphoma
L5178Y TK+/- Mouse Lymphoma Mutagenesis Mutagenicity Evaluation of API #83-O4 in the mutation assay. Final report. (34-32643)
Assay of API 83-08, [Light Catalytic Mouse Lymphoma Forward Mutation Mutagenicity of API 83-12, hydrotreated light
Cracked Distillate] (32-31709) Assay. Final Report. (32-32168) naphthenic distillate (CAS 64742-53-6) in
L5178Y TK+/- Mouse Lymphoma Mutagenesis Mutagenicity Evaluation of API #83-I1 in the a mouse lymphoma mutation assay. Final
Assay of API [Sample] 83-19, Light Al- Mouse Lymphoma Forward Mutation report. (33-32802)
kylate Naphtha. Final Report. (32-32746) Assay. (32-32166) Mutagenicity of API 83-15, hydrotreated heavy
L5178Y TK+/- Mouse Lymphoma Mutagenesis Mutagenicity Evaluation of API 78-5, 100 naphthenic distillate, (CAS 64742-52-5).
Assay. API 83-06. heavy catalytically SUS/100 "F Naphthenic Oil. Final Repon. in a mouse lymphoma mutation assay.
reformed naphtha (CAS 64741-68-0). (29-32359) Final report. (33-32800)
Final report [by Microbiological Mutagenicity Evaluation of API 79-1, 90 Mutagenicity of API 83-16, light paraffinic
Associates Inc.]. (33-31641) SUS/210 "F Naphthenic Oil. Final Repon. distillate solvent extract (petroleum) (CAS
L5178Y TK+/- Mouse Lymphoma Mutagenesis (29-32360) 6474245-8). in a mouse lymphoma
Assay. API [Sample] 83-09. Straight-Run Mutagenicity Evaluation of API 83-07 in the mutation assay. Final report. (33-32803)
Kerosine (CAS 8008-20-6). Final Report. Mouse Lymphoma Forward Mutation Mutagenicity of API 83-18, heavy catalytic
(32-32745) Assay. Final Reports. (32-32167) cracked naphtha (petroleum) (CAS
Mutagenic Evaluation of 60 Solvent Mutagenicity Evaluation of Benzene ...Final 64741-54-4), in a mouse lymphoma
(CHF-33-148). (26-60003) Report. (26-60092) mutation assay. Final report. (33-32804)
Mutagenic Evaluation of Filtered Rubber Mutagenicity Evaluation of Catalytic Reformed Mutagenicity of API 83-20, light catalytic
Solvent (CHF-32-263). (26-60016) Naphtha, API #83-05. in the Mouse cracked naphtha (CAS 64741-55-5) in a
Mutagenic Evaluation of Rubber Solvent Lymphoma Forward Mutation Assay. mouse lymphoma mutation assay. Final
(CHF-32-263). (26-60011) Final Report. (32-32459) repon. (34-30633)
Mutagenicity Evaluation Studies [of Catalyt- Mutagenicity Evaluation of Certified Cyclo- Mutagenicity of API 84-01, light paraffinic
ically Cracked Clarified Oil (API Sample hexane. Final Report. (29-32357) distillate (CAS 64741-504). in a mouse
#81-15)] in the Rat Bone Marrow Mutagenicity Evaluation of Diesel Fuel. (26- lymphoma mutaiion assay. Final report.
Cytogenetic Assay and in the Mouse 60102) (33-32801)
Lymphoma Forward Mutation Assay. Mutagenicity Evaluation of Kerosene. Finai Mutagenicity of API 84-02, heavy thermal
Final Report. (32-30534) Repon. (26-60017) cracked naphtha (CAS 64741-83-9) in a
Mutagenicity Evaluation Studies [of Hydro- Mutagenicity Evaluation of Petroleum Hydro- mouse lymphoma muiation assay. Final
desulfurized Middle Distillate (D). API carbons. (30-31997) report. (34-30632)
Sample 81-10] in the Rat Bone Marrow Mutagenicity Evaluation of Raw Shale. Final Mutagenicity of API 85-01, Stoddard solvent
Cytogenetic Assay and in the Mouse Report. (26-60044) (CAS 8052-41-3). in a mouse lymphoma
Lymphoma Forward Mutation Assay. Mutagenicity Evaluation of Retorted Shale. mutation assay. Final report [by Litton
Final Report. (32-30535) Final Report. (26-60006) Bionetics Inc.]. (34-30329)
Mutagenicity Evaluation Studies in the Rat Mutagenicity Evaluation of Stoddard [Solvent] The Ls178Y TK +I- mouse lymphoma
Bone Marrow Cytogenetic Assay [and] in "Fuel". (26-60010) mutagenesis assay with octane. Final
the Mouse Lymphoma Fonvard Mutation Mutagenicity Evaluation of Toluene. (26-60020) repon. (35-31365)
Assay of Light Catalytically Cracked Mutagenicity Evaluation of Unleaded Gasoline: The L5178Y TK+/- mouse lymphma
Naphtha, [API] Sample 81-03. Final Final Report. (28-30173) mutagenesis assay with
Report. (32-31300) Mutagenicity Evaluation of Xylene. (26-60018) 2.2.4-trimethylpentane. Final report. (34-
Mutagenicity Evaluation Studies in the Rat Mutagenicity Evaluation of [Raw Shale] 33107)
Bone Marrow Cytogenetic Assay [and] in RS-101. Final Report. (26-60021) The L5178Y TK+/- mouse lymphoma muta-
the Mouse Lymphoma Forward Mutation Mutagenicity Evaluation of [Shale Oil] R-01. genesis assay with 2,3dimethylbutane.
Assay. Hydrodesulfunzed Kerosine, API Draft Report. (26-60004) Final report. (34-33109)
Sample 81-07. Final Report. (32-30240) Mutagenicity Evaluation of [Shale Oil] R-03. [A Final Report by Litton Bionetics Inc. on]
Mutagenicity Evaluation Studies in the Rat Draft Report. (26-60005) Mutagenicity Evaluation Studies in the
Bone Marrow Cytogenetic Assay [and] in Mutagenicity Evaluation of [Shale Oil] R-04. Mouse Lymphoma Fonvard Mutation
the Mouse Lymphoma Forward Mutation (26-60009) Assay (with] Sweetened Naphtha, [API]
Assay. Vacuum Residu um...API Sample Mutagenicity in a mouse lymphoma mutation Sample 81-08. (32-31233)

37
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 0732290 O549997 O86 =

[ïñis final report on]the L5178Y TK+/- mouse Paraffinic Oil 78-9,70 SUS/l00 OF. Final Mutagenicity Evaluation Studies in the Rat
lymphoma mutagenesis assay with API Report. (28-31864) Bone Marrow Cytogenetic Assay and in
220-280 OF distillate fraction of unleaded In-Vivo and In-Vitro Mutagenicity Studies. lhe Mouse Lymphoma Forward Mutation
gasoline (34-33108) Paraffinic Oil 79-3, 350 SUS/100 OF. Assay. Vacuum Residu um...API Sample
Final Report. (28-31865) 8 1-14. (31-30615 )
Mouse ovarian tumor cell atiaclrnteni assay In-Vivo and In-Vitro Mutagenicity Studies. Mutagenicity Evaluation of 83-05 in the Rat
Paraffinic Oil 79-4, 550 SUS/100 OF. Bone Marrow Cytogenetic Assay. Final
Mouse ovarian tumor (MOT) cell attachment Final Report. (28-31866) Report. (32-32289)
assay with APl 81-15: Catalytic cracked In-Vivo and In-Vitro Mutagenicity Studies. Mutagenicity Evaluation of API 78-5, 100
clarified oil. Final report. (35-32480) Paraffinic Oil 79-5, 800 SUS/100 OF. SUS/lOO "F Naphthenic Oil. Final Report.
Mouse ovarian tumor (MOT) cell attachment Final Report. (28-31867) (29-32359)
assay with API 86-02: Solvent refined In-Vivo and In-Vitro Mutagenicity Studies. Mutagenicity Evaluation of API 79-1, 90
coal distillate. Final report. (35-32481) Quench Water from Delayed Process SUS/210 "F Naphthenic Oil. Final Report.
Mouse ovarian tumor (MOT) cell attachment Coke. Liquid 7-1-100. A Revised Final (29-32360)
assay with benzo(a)pyrene. (37-31149) Report (28-30725) Mutagenicity Evaluation of Benzene ...Final
Mouse ovarian tumor (MOT) cell attachment In-Vivo and In-Vitro Mutagenicity Studies. Report. (2660092)
assay with toluene. (37-31 150) Solid Condensed Emission Product from Mutagenicity Evaluation of Certified
Delayed Coke Process. (Petroleum Coking Cyclohexane. Final Report. (29-32357)
Rat bone marrow cyïogenetics Sample 3-1-134). (28-30727) Mutagenicity Evaluation of Diesel Fuel. (26-
In-Vivo and In-Vitro Mutagenicity Studies. 60102)
Activity of API 81-04 in the Acute In-Vivo n-Hexane (Hexane UV). Final Report. Mutagenicity Evaluation of Kerosene. Final
Cytogenetics Assay in Male and Female (28-31628) Report. (26-60017)
Rats. Final Report. (32-32288) Inhalation Cytogenetics in Mice and Rats Mutagenicity Evaluation of Petroleurn Hydro-
Activity of API 83-06 (heavy catalytic refomed Exposed to Benzene. (30-31996) carbons. (30-31997)
naphtha) in the acute in vivo cytogenetics Mutagenic Evaluation of 60 Solvent Mutagenicity Evaluation of Raw Shale. Final
assay in male and female rats. Final (CHF-33-148). (26-60003) Report. (26-60044)
report. (33-30494) Mutagenic Evaluation of Filtered Rubber Mutagenicity Evaluation of Retorted Shale.
Activity of API 83-08 (light catalytic cracked Solvent (CHF-32-263). (26-60016) Final Report. (26-60006)
distillate) in the acute in-vivo cytogenetics Mutagenic Evaluation of Rubber Solvent Mutagenicity Evaluation of Stoddard [Solvent]
assay in male and female rats. Final (CHF-32-263). (26-6001 1) "Fuel". (26-60010)
report. (33-30493) Mutagenicity Evaluation Studies [of Mutagenicity Evaluation of Toluene. (26-60020)
Acute In-Vivo Cytogenetics Assay in Male and Catalytically Cracked Clarified Oil (API Mutagenicity Evaluation of Unleaded Gasoline:
Female Rats of API 83-1 1. Final Report. Sample #81-15)] in the Rat Bone Marrow Final Report. (28-30173)
(32-32408) Cytogenetic Assay and in the Mouse Mutagenicity Evaluation of Xylene. (26-60018)
Acute In-Vivo Cytogenetics Assay in Male and Lymphoma Forward Mutation Assay. Mutagenicity Evaluation of [Raw Shale]
Female Rats of APl 83-19. Final Report. Final Report. (32-30534) RS-lol. Final Report. (26-60021)
(32-32409) Mutagenicity Evaluation Studies [of Mutagenicity Evaluation of [Shale Oil] R-01.
Evaluation of C, aromatic hydrocarbons for Hydrodesulfurized Middle Distillate 0). Draft Report. (2660004)
mutagenic potential ...Bone marrow API Sample 81-10] in the Rat Bone Mutagenicity Evaluation of [Shale Oil] R-03.
cytogenetics test in rats. Final report. (35- Marrow Cytogenetic Assay and in the Draft Report. (26-60005)
30936) Mouse Lymphoma Forward Mutation Mutagenicity Evaluation of [Shale Oil] R-04.
Further Studies of the Mutagenicity of Assay. Final Report. (32-30535) (26-60009)
Hydrocarbon Fractions [by] Utilizing Mutagenicity Evaluation Studies in the Rat Mutagenicity evaluation in the rat bone marrow
Somatic Mutations in Rais. (26-60100) Bone Marrow Cytogenetic Assay [and] in cytogenetic assay. AP1 81-08. sweetened
In-Vitro and In-Vivo Mutagenicity Studies. Jet the Mouse Lymphoma Forward Mutation naphtha (CAS 64741-87-3). Final report
Fuel A. Final Report. (27-30051) Assay of Light Catalytically Cracked [by Litton Bionetics Inc.]. (33-31093)
In-Vitro and In-Vivo Mutagenicity Studies. Naphtha, [API] Sample 81-03. Final Mutagenicity evaluation in the rat bone marrow
New Oil Composite [Motor Oil]. Final Report. (32-31300) cytogenetic assay. API 83-04. light
Report. (27-00325) Mutagenicity Evaluation Studies in the Rat catalytically reformed naphtha (CAS
In-Vitro and In-Vivo Mutagenicity Studies. No. Bone Marrow Cytogenetic Assay [and] in 64741-63-5). Final report [by Litton
2 Home Heating Oil. Final Report. (27- the Mouse Lymphoma Forward Mutation Bioiietics Inc.]. (33-31092)
30140) Assay. Hydrodesulfurized Kerosine, APl Mutagenicity evaluation in the rat bone marrow
In-Vivo and In-Vitro Mutagenicity Studies. Sample 81 -07. Final Report. (32-30240) cytogenetic assay. API 83-07. light
Delayed Process Coke. (Petroleum Coking Mutagenicity Evaluation Studies in the Rat catalytically cracked distillate (CAS
Sample 4-1-140). A Revised Final Report. Bone Marrow Cytogenetic Assay [and] in 64741-59-9). Final report. (33-30929)
(28-30728) the Mouse Lymphoma Forward Mutation Mutagenicity evaluation in the rat bone marrow
In-Vivo and In-Vitro Mutagenicity Studies. Assay. Vacuum Residu um...API Sample cytogenetic assay. API 83-11, straight run
Fluid Process Coke. (Petroleum Coking 81-13. (31-30614) middle distillate (CAS 64741-44-2). Final
Sample 6-1468). A Revised Final Report. Mutagenicity Evaluation Studies in the Rat report. (33-30930)
(28-30726) Bone Marrow Cytogenetic Assay and in Rat Bone Marrow Cytogenetic Analysis [for]
In-Vivo and In-Vitro Mutagenicity Studies. the Mouse Lymphoma Forward Mutation Unleaded Gasoline ...Final Report. (26-
Paraffinic Oil 78-10. 150 SUS/IOO "F. Assay. Hydrodesulfurized Middle 60099)
Final Report. (28-31868) Distillate. API Sample 81-09. Final Subchronic in-vivo cytogenetics assay in rats
In-Vivo and In-Vitro Mutagenicity Studies. Report. (32-30965) using nose-only inhalation exposure to

38
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 95 O732290 0549998

commercial hexane. Final report. (37- In vivo sister chromatid exchange assay with Fare and Effecis
31830) API 81-03 (light catalytically cracked
The Acute in-Vivo Cytogenetics Assay in Male naphtha). Final report. (36-30044) The Effects of Oil on Estuarine Animals:
and Female Rats of API 83-09 In vivo sister chromatid exchange assay with Toxicity, Uptake and Depuration,
[(Straight-Run Kerosine)]. Finai Report. API 81-07, hydrodesulfurized kerosine. Respiration. (26-60030)
(32-31769) Final report. (36-30043)
The mutagenic potential of high flash aromatic in vivo sister chromatid exchange assay API MerabolismlPharmacokinetics
naphtha. (36-33132) RO-1 raw shale oil. (37-32484)
In vivo sister chromatid exchange assay with Absorption of petroleum products across the
Sisïer chromatid exchange (in-virro)(CHO) API 83-07 (light catalytic cracked skin of the monkey and miniature pig.
distillate). (36-3 1429) Annual report (Mar. 15, 1979-Mar. 14,
Mutagenicity test on ASTM D-3734 Type I C, In-vivo sister chromatid exchange assay with 1980). (33-31034)
in an in vitro cytogenetic assay measuring API 81-10: Hydrodesulfurized middle
sister chromatid exchange frequencies in distillate. Final report. (35-32479) NAPHTHENIC AROMATIC SOLVENT
Chinese hamster ovary (CHO) cells. Final
report. (35-30933) Unscheduled DNA synthesis Toxicity Study
Sister Chromatid Exchange Assay in Chinese
Hamster Ovary (CHO) Cells [Exposed to] An Evaluation of the Potential of RO-1, 81-15. Petroleum Hydrocarbon Toxicity Studies-16.
PS-8-DS-Saturates. Final Report. (32- and PSS-76D5-SAT T o Induce Animal Response to Vapors of
32731) Unscheduled DNA Synthesis [(UDS)] in "Naphthenic Aromatic Solvent" (27-
Sister Chromatid Exchange Assay in Chinese Primary Rat Hepatocyte Cultures (32- 31351)
Hamster Ovary (CHO) Cells. API 81-15. 32407)
Catalytically Cracked. Clarified Oil (CAS An Evaluation of the Potential of RO-1. 81-15, NAPHTHENIC BASE STOCK
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

64741-62-4). Final Report. (32-32750) and PS8-76D5-SAT To induce


Sister chromatid exchange assay in Chinese Unscheduled DNA Synthesis [(UDS)] in Mirtagenicity Study
hamster ovary (CHO) cells with API the in Vivo-in Vitro Hepatocyte DNA
81-10: Hydrodesuifurized middle distillate. Repair Assay (32-32406) Mutagenicity Evaluation of API 78-5, 100
Final report. (35-32433) Evaluation of the potential of PS-8-76DS-ARO SUS/iOO O F Naphthenic Oil. Final Report.
Sister chromatid exchange assay in Chinese to induce unscheduled DNA synthesis (29-32359)
hamster ovary (CHO) cell with API [(UDS)] in the in-vivolin-vitro hepatocyte
8i -07: Hydrcdesul furi zed kerosine. Fi na1 DNA repair assay. Final report [by SRI Toxiciw Srudy
report. (35-32482) Intemational]. (33-31 826)
Sister chromatid exchange assay in Chinese Evaluation of the potential of PS-8-76D5-ARO [Project No. 16161 Acute Toxicity Tests of API
hamster ovary (CHO) cells with API to induce unscheduled DNA synthesis in 78-5, Naphthenic Oil (150 SUS/iOO OF).
81-03 [(light catalytically cracked primary rat hepatocyte cultures. Final (29-33106)
naphtha)]. Final report. (36-30045) report [by SRI Intemational]. (33-31751)
Sister Chromatid exchange assay in Chinese Unscheduled DNA synthesis ((UDS) in rat
hamster ovary (CHO) cells with API primary hepatocytes with PS-6 unleaded NAPHTHENIC BASE STOCK (ViSCOSITY
83-07: Light catalytic cracked distillate. gasoline, its evaporation residue, and a (SUS/100 O F ) 2000)
(35-32432) DMSO ((dimethylsulfoxide) extract. (35-
Sister chromatid exchange assay in Chinese 32431) Carcinogenicity Study
hamster ovary (CHO) cells. API
PS-8-76D5 aromatics. Final repon [by NAPHTHA Short-temi demal tumorigenesis study of selec-
Microbiological Associates Inc.]. (33- ted petroleum hydrocarbon [processing
30931) Developniental Effects fractions] in male CD-I mice. initiation
Sister chromatid exchange assay in Chinese and promotion phases. (36-32643)
hamster ovary (CHO) cells: API RO-1, Inhalation Teratology of Jet Fuel A. Fuel Oil, The Carcinogenicity of New and Used
raw shale oil. Final repon. (33-30445) and Petrolum Naphtha in Rats. (30-32003) Lubricants. (30-32847)
The mutagenic potential of high flash aromatic
naphtha. (36-33132) NAPHTHA (REVIEW) Micfagenicity Sfirdy

Sister chroniatid exchange (in-vivo) Tarici- Stidy Miitagenicity Evaluation of API 79-1, 90
SUSRIO "F Naphthenic Oil. Final Report.
An in-vivo sister chromatid exchange assay of Clinical toxicology of the acute ingestion of (29-32360)
API P S - 8 - 7 6 D S - A R 0 , aromatic methanol/hydrocarbon blends. A Mutagenicity Evaluation of Petroleum Hydro-
subtraction of 700-1070 "F boiling range state-of-the-art review. (39-31093) carbons. (30-31997)
fraction of a crude oil. (35-32013)
in Vivo Sister Chromatid Exchange Assay, API NAPHTHALEKE Toxicity Study
81-15, Catalytically Cracked. Clarified Oil
(CAS 64741-62-4). Final Repon. (32- A na ly fica1 Cheniistryl Metliodology The Acute Toxicology of Selected Petmleum
32754) Hydrocarbons. (30-31530)
In-vivo sister chromatid exchange assay. API The Effects of Oil on Estuarine Animals: [Project No. 15971 Acute Toxicity Tests of API
PSS-76D5 saturates. Final repon. (33- Toxicity. Uptake and Depurdtion. 79-1, Naphthenic Oil (90 SUS/2IO OF).
30932) Respiration. (26-60030) (29-33065)

39

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 0732290 0 5 4 7 9 9 9 9 5 9 m

NAPHTHENIC BASE S ï O C K (VISCOSiTY toluene. (30-32009) NITROGEN DIOXIDE


(sus/loo"F)80) [BioDynamics Inc. Project No. 77-19211 A 26-
Week Inhalation Toxicity Study of Toxicity Study
Carcinogenicity Stiuìy n-Hexane in the Rat. (28-30077)
Study of Synergistic Effects of Certain Airborne
The Carcinogenicity of New and Used Oral Systems in the Cynomolgus Monkey. (27-
Lubricants. (30-32847) 30704)
Neurobehavioral Toxicology of Petroleum- and
Mutagenicity Study Shale-Derived Jet Propulsion Fuel No. 5 NITROGEN DIOXIDE (REVIEW)
(JP5). (30-31533)
Mutagenicity Evaluation of Petroleum Hydro- Toxiciry Stiuiy
carbons. (30-31997) Research Merhodology
A Unified Approach to the Use of Human
Toxicity Sruúy Validation of behavioral studies for determining Clinical Data: A Case Study of Nitrogen
neurotoxicity. Final repon. (31-31472) Dioxide and Sulfur Dioxide. (32-32502)
The Acute Toxicology of Selected Petroleum
Hydrocarbons. (30-31530) Review NITROGEN OXIDE (REVIEW)

NEUROTOXICITY STUDY A Tale of Two Solvents: The Neurology of Human Exposure Assesmeni
n-Hexane and Toluene. (30-32079)
i n virro Neurophysiological and Psychological Disorders Photochemical Smog. (2660108)
and Occupational Exposure to Organic
Experimental Studies of Hexacarbon Solvents. (31-32980) NITROGEN OXIDES
Neurotoxicity. Final Repon. (29-32291) Neurotoxicity of organic solvents with special
reference to the neurobehavioral effects: A Ana iyrica 1 Chemistryl Methodology
Inhalation [world] literature review (39-30623)
The Effects of n-Hexane in Man and Animals. [In] a Program for Upgrading the NO, Instru-
A 13 week inhalation study of potential effects (30-3 1603) mentation Employed in the 1972 Chat-
of mmmercial hexane on behavior and tanooga NO, Exposure Study (26-60051)
neuromorphology in rats. (37-31154) NICKEL (REVIEW)
A Comparison of the Rate of Development of Toxiciry Srudy
Hexane Neuropathy in Weanling and Toxiciry Sridy
Young Adult Rats. (30-32007) Effects of Oxides of Nitrogen, Carbon Monox-
An Experimental Evaluation of Selected Petro- Nickel. (26-601 12) ide and Photochemical Oxidants on the
chemicals for Subchronic Neurotoxic [Electrocardiogram] during Exercise and
Properties. (30-32004) NICKEL SUBSULFIDE on Cardiopulmonary Function. Final
Concentration-Related Effects of Hexane on Report (APRAC Project CAPM-21-74).
Evoked Responses from Brain and Toxicity Srudy (26-60045)
Peripheral Nerve. (30-32006)
Effects of Toluene Exposure on Auditory A Mechanistic Evaluation of the Pulmonaiy NITROGEN OXIDES (REVIEW)
Pathways. Final Repod. (3 i-32169) Toxicology of Nickel Subsulfide. (30-
Histopathological Analysis of Spinal Cord of 31992) Toxiciry Study
Animals Exposed to Gasoline. Final
Report. (30-30225) NIOBIUM (REVIEW) Oxidants: Air Quality Crieria Based on Health
Inhalation neurotoxicity study in rats with C, Effects. (26-60060)
aromatic hydrocarbons. (35-32084) Toxiciiy Siudy
Neurobehavioral Effects of Subchronic NITROUS OXIDE
Exposure of Weanling Rais to Toluene or Vanadium. (26-601 11)
Hexane. (30-32008) Amlyrical ChernistryiMethodoiogy
Neuropathic Potential of n-Hexane in the NITRATE
Presence of Other Hexane Isomers. Final [in] a Program for Upgrading the NO, Instru-
Report: [Phase 1 and Phase 21. (30-30226) Toxicity Sridy mentation Employed in the 1972 Chat-
Quantitative Analysis of Pathological Changes tanwga NO2 Exposure Study (26-60051)
in the Cervical Spinal Cord of Control and Effeas of Nitrate and/or Sulfate Aerosols upon
n-Hexane-Treated Rats. Final Report. (30- Cardiopulmonary Function. Final Repon NO. 2 FUEL O I L
30223) [for First Year of Project]. (27-30842)
Si-MonthContinuous Inhalation Exposures of Aqiiaiic Toxicity
Rats to Hexane Mixtures ...Phase II. (30- NITRIC OXIDE
32846) Effects of Oil and Chemically Dispersed Oil on
Toluene-Induced Hearing Loss in Rats Evi- Amlyrical Ckernisr~lMerhodology Selected Manne Biota... A Laboratory
denced by the Btainstem Auditory-Evoked Study. (26-60050)
Response [(BAER)]. (30-32077) [In] a Program for Upgrading the NO, Instru- Laboraiory Studies on the Effects of Oil on
Transient cognitive deficits and high-frequency mentation Employed in the 1972 Chat- Manne Organisms: An Overview (26-
hearing loss in weanling rats exposed to tanooga NO2 Exposure Study (26-60051) 60055)

40
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 9 5 = O732290 0 5 5 0 0 0 0 Ob4 =

The Effects of Oil on Estuarine Animals: NO. 2 HOME HEATING OIL (30% C C NO. 6 FUEL OIL, SPEC. GRAV. 1.0?,
Toxicity, Uptake and Depuration, STOCK) SULFUR 1.2%
Respiration. (26-60030)
The Toxicity of Water-Soluble Fractions of Toxicity Sfudy
Four Test Oils for the Polychaetous Toxicity Siudy
Annelids Neanrhes arenaceodenrata and [Project No. 14431 Acute Toxicity Tests of API
Capitella capiraia. (26-60002) [Project No. 14431 Acute Toxicity Tests of API 79-2 No. 6 Heavy Fuel Oil (5.2 'API/
#78-2 No. 2 Home Heating Oil (30% Cat) 1.2% S) (27-32813)
Carcinogenicity Srirdy (27 -32771)
NOISE
Lifetime dermal carcinogenesis bioassay of
refinery streams in C3H/HeJ mice NO. 2 HOME HEATING OIL (50% C C Occiiprional Healih
(AP-l35R). (36-31364) STOCK)
Guidelines on Noise (26-60119)
Fare and Effects Developmental Effecrs
n-NONANE
Laboratory Studies on the Effects of Oil on Inhalatiodïeratology Study in Rats. Fuel Oil.
Marine Organisms: An Ovetview (26- Final Report. (27-30483) MetabolismlPharmacokinetìcs
60055)
The Effects of Oil on Estuarine Animals: Toxicity Siudy Studies on the absorption of inhaled hydro-
Toxicity, Uptake and Depuration, carbon vapors. Final report. (34-33036)
Respiration. (26-60030) [Project No. 14431 Acute Toxicity Tests [on]
Uptake and Depuration of Specific Hydro- API #78-4. No. 2 Home Heating Oil (50% Toxiciry Siudy
carbons from Oil by the Bi-valves Rangia Cat) (27-32068)
cuneata and Crassostrea Virginica. (26- Petroleum Hydrocarbon Toxicity Studies--17.
60072) Animal Response to n-Nonane Vapor (27-
NO. 6 FUEL O I L 31352)
MetabolisrnlPharmacokinerics
Toxicity Study OCCUPATIONAL HEALTH
The Induction of Xenobiotic Metabolism in
Rats on Exposure to Hydrocarbon-Based The Acute Toxicology of Selected Petroleum A Health Survey of Petroleum Asphalt
Oils. (30-31995) Hydrocarbons. (30-31530) Workers. (2640093)
A case-control study of kidney cancer among
Mirtagenicity Sftidy petroleum refinery workers. Final report.
NO. 6 FUEL OIL, SPEC. GRAV. 0.92, (37-31336)
Mutagenicity Evaluation of Petroleum Hydro- SULFUR 0.2% A mortality study of marketing and manne
carbons. (30-31997) distribution workers with potential
exposure to gasoline in the petroleum
Toxicity S r d y Toxicity Srrd.y industry. (39-33438)
A nested case-control study of kidney cancer,
The Acute Toxicology of Selected Petroleum [Project No. 14431 Acute Toxicity Tests...API leukemia and multiple myeloma in a
Hydmahons. (30-31530) 78-8 No. 6 Heavy Fuel Oil (23.1 "APII cohort of land-based terminal workers
0.2% S). (27-32816) exposed to gasoline in the petroleum
NO. 2 HOME HEATING O I L industry. (41-32613)
An update of a mortality study of workers in
Developmenraì Eflecis NO. 6 FUEL OIL, SPEC. GRAV. 0.95, petroleum refineries. (33-32726)
SULFUR 0.8% Aseptic Bone Necrosis Occurring in Persons
Inhalation Teratology of Jet Fuel A. Fuel Oil. Who Work under Pressure. (2660042)
and Petrolum Naphtha in Rats. (30-32003) Assessment of the Healthy Worker Effect
[(HWE)]. F i d Report. (31-30449)
Miiragenicity Stiidy [Project No. 14431 Acute Toxicity Tests of API Deep-Water Petroleum Production Systems.
78-7 No. 6 Heavy Fuel Oil (17.1 "API/ (26-M)036)
In-Vitro and In-Vivo Mutagenicity Studies. No. 0.8% S) (27-32774) Experiments in Human Work Capabilities
2 Home Heating Oil. Final Report. (27- Under Pressure Now Being Conducted at
30140) the Royal Naval Physiological Laboratory.
NO. 6 FUEL OIL, SPEC. GRAV. 0.99, (26-60033)
NO. 2 HOME HEATING OIL (10% C C SULFUR 2.7% Experiments in Human Work Capabilities under
STOCK) Pressure. Now Being Conducted at the
Institute for Environmental Medicine,
Toxicity Study Toxicity Sïiuìy University of Pennsylvania. (2660117)
Functions Performed by Divers in Offshore
[Project No. 14431 /Acute Toxicity Tests of [Project No. 14431 Acute Toxicity Tests. API Petroleum Production. (26-60034)
AP1#78-3 No. 2 Home Heating Oil (10% 78-6 No. 6 Heavy Fuel Oil (11.7 "API/ Guidelines on Noise. (26-601 19)
Cat) (27-32773) 2.7% S). (27-32814) Implications in the Occupational Safety and

41
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
Health Act of 1970 Upon the Operational Mero holismlPliorn~acokiirPrics OIL MIST
Costs of Diving Services. (26-60039)
Implications of the Occupational Safety and Studies on the absorption. tissue equilibria and Humun Exposure Assessrneni
Health Act of 1970 [OSHA] to Industry. excretion routes of inhaled hydrocarbon
(26-60037) vapors and their metabolites (36-31430) Oils Mist: [An] Evaluation of [Workplace]
Industrial Hygiene Assessment of Petroleum Sampling Procedures. (26-601 18)
Refinery Tumaround Activities. Final
Report. (32-31555) Toxicity Study OZONE
Job code classificaiion system-2. Production
operations and marketinghnsportation Final Report. A four-week orai nephrotoxicity Hitman Expositre Assessrneni
Operations (33-30051) screening study in male F344 rats (33-
Kidney Cancer Epidemiology in Petroleum- 31097) Development and Persistence of Adaptation to
Related Studies. (32-30420) Ozone Exposure in Ozone-Sensitive
LA-8459-MSParaho Oil Shale Workers Southem California Residents. (28-33073)
Occupational Health Study. (27-33273) n-OCTANE Numerical Modeling of Ozone Population
Medical Implications of the Occupational Exposure: Application to a Comparison of
Safety and Health Act in the Diving Beliasiorol Stiufy Alternative Ozone Standards. Final
Industry (26-60038) Report. (32-32309)
Occupational Safety Problems in the Diving The Effects of n-Octane Exposure on Schedule-
Industry. (2640040) Controlled Responding in Mice. (30- Toxicity Study
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Occupational Safety and Health Problems of the 32080)


Diving Industry in Offshore Petroleum Duration of [Human] Pulmonary Hyperrespon-
Production. (26-60031) siveness to Acute Ozone Exposure. Final
Overview of the Seminar's Objectives. MetabolisntlPliarntacokinetics Report. (32-31232)
[Seminar on Deep Sea Diving and the Effects of Oxides of Nitrogen, Carbon Monox-
Petroleum Industry]. (26-60032) Studies on the absorption of inhaled hydro- ide and Photochemical Oxidants on the
Review of the Status of Biological Aspects of carbon vapors. Final report. (34-33036) [Electrocardiogram] during Exercise and
Coal Conversion Technology, on Cardiopulmonary Function. Final
1977-Present. Final Report. (28-31863) Report (APRAC Project CAPM-21-74).
Statistical approaches for assessing exposures to n-OCTANE, DEUTERATED (26-60045)
chemicals. (33-31 163) Short-Tenn Responses of Healthy and
Surveillance of Reproductive Health in the Metabolisni/Pliarrnacokinetics Asthmatic Men to Ozone. Final Report,
US.: A Survey of Activity Within and Phase 1: A Dose-Response Study of
Outside Industry. (32-30187) Studies on the absorption of inhaled hydro- Healthy. Heavily Exercising Men Exposed
The Present and Projected Capabilities of the carbon vapon. Final report. (34-33036) to Ozone Concentrations near the Primary
Diving Industry in the Support of [National Ambient Air Quality] Standard
Offshore Petroleum Production. (26- [(NAAQS)]. (32-32755)
60035) ODOR AND TASTE
The Unknowns in Decompression Table OZONE (REVIEW)
Calmlation and Their Implications in A 14 day palatability and stability study in
Occupational Safety and Health. (26- mice with benzene administered in Hiinion Exposure Assessrneni
60041) drinking water. (37-32486)
[Seven] Epidemiologic Studies of the Role of A 14 day palatability and stability study in rats Photochemical Smog. (26-60108)
Gasoline (Hydrocarbon) Exposure in with benzene administered in drinking
Kidney Cancer Risk (32-3041 1) water. (37-32485) Taricity Sit&
Detectability and Irritability of Hydrocarbons
[Stoddard Solvent and 70 Solvent] in A Unified Approach to the Use of Human Cli-
2~,4,4,5,5,7,7-OCrAMET" LOCTANE Human Subjects. Final Report to nical and Animal Toxicologic Data; A p
American Petroleum Institute. Contract plication to the Establishment of Ambient
U-15-14-PS-5. (26-60025) Air Quality Criteria. Volume IA: Effect of
Toxiciry Study Human Sensory Response to Selected Ozone on Airway Resistance (Raw) and
Petroleum Hydrocahons. (30-32081) Forced Expiratory Volume (FEV,,) in
Final Report. A four-week orai nephrotoxicity Odor and taste threshold studies performed with Humans. Final Report. (32-32503)
screening study in male F344 rats. (33- tertiary-amyl methyl ether (TAME). (40- Oxidants: Air Quality Criteria Based on Health
31097) 06424) Effects. (26-60060)
Odor threshold studies performed with gasoline
and gasoline combined with MTBE. PARAFFINIC BASE STOCK (VISCOSrrU
OCTANE ETBE, and TAME. (41-01257) (SUS/lOO OF) 133)
Petroleum Hydrocarbon Toxicity Studies--14.
Mirtagenicity Study Animal and Human Response to Vapors Anaìyticaì ChernistrylMeiliodology
of "High Aromatic Solvent." (27-31349)
The L5178Y TK +/- mouse lymphoma niuta- [A literature] review of published odor and taste Polynuclear aromatic analyses and modified
genesis assay with octane. Final report. threshold values of [the 2761 soluble Ames tesis on base lube [lubricating]
(35-31365) gasoline components. (33-30589) stocks. (36-33219)

42

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*Yb3Y 95 m 0 7 3 2 2 9 0 0 5 5 0 0 0 2 937 m

Carcinogenicity Study PARAFFINIC BASE STOCK (VISCOSITY [Proj. No. 16011 Acute Toxicity Tests of API
(SUS/100 OF) 485) 78-9, Paraffinic Oil 0 0 SUS/lOO OF). (29-
33 104)
The Carcinogenicity of New and Used Analyrical CliemisrrylMethodology
Lubricants. (30-32847) PARAFFINIC BASE STOCK (VISCOSITY
Polynuclear aromatic analyses and modified (sus/ioo OF) 990)
Ames tests on base lube [lubricating]
Miitagenicity Study stocks. (36-33219) y-
Analytical CliemistrylMethodology

In-Vivo and in-Vitro Mutagenicity Studies. Carcinogenicity Study Polynuclear aromatic analyses and modified
Paraffinic Oil 78-10, 150 SUS/lDo 'F. Ames tesis on base lube [lubricating]
Final Report. (28-31868) The Carcinogenicity of New and Used stocks. (36-33219)
Mutagenicity Evaluation of Petroleum Hydro- Lubricants. (30-32847)
carbons. (30-31997) Carcinogenicity Study
Polynuclear aromatic analyses and modified Mutagenicity Study
Ames tests on base lube [lubricating] The Carcinogenicity of New and Used
stocks. (36-33219) In-Vivo and In-Viwo Mutagenicity Studies. Lubricants. (30-32847)
Paraffinic Oil 79-4, 550 SUS/100 "F.
Final Report. (28-31866) Mutageniciry Study
Toxicity Stiuiy Mutagenicity Evaluation of Petroleum Hydro-
carbons. (30-31997) In-Vivo and In-Vitro Mutagenicity Studies.
The Acute Toxicology of Selected Petroleum Polynuclear aromatic analyses and modified Paraffinic Oil 79-5, 800 SUS/lûû "F.
Hydrocarbons. (30-31530) Ames tests on base lube [lubricating] Final Report. (28-31867)
[Project No. 16021 Acute Toxicity Tests of API stocks. (36-33219) Mutagenicity Evaluation of Petroleum Hydro-
78-10, Paraffinic Oil (150 SUS/lOO O F ) . carbons. (30-31997)
(29-33105) Toxicity Smdy Polynuclear aromatic analyses and modified
Ames tests on base lube [lubricating]
T h e Acute Toxicology of Selected Petroleum stocks. (36-33219)
PARAFFINIC BASE m O C K (VISCOSITY Hydrocarbons. (30-3 1530)
(SUS/lOO OF) 331) [Project No. 15991 Acute Toxicity Tests of API Toxicity Study
79-4, Paraffinic Oil (550 SUS/lOû OF).
(29-33066) The Acute Toxicology of Selected Petroleum
A na ly rica 1 Clremistry/Met lidology Hydrocarbons. (30-31530)
[Project No. 16001 Acute Toxicity Tesis, API
Polynuclear aromatic analyses and modified PARAFFINIC BASE STOCK (VISCOSITY 79-5, Paraffinic Oil (800 SUS/lOO OF).
Ames tests on base lube [lubricating] (SUSllOO O F ) 65) (29-33068)
stocks. (36-33219)
A na ly rica1 Chemistry1Metlidology PARTICULATES

Carcinogenicity Swdy Polynuclear aromatic analyses and modified Analytical CheniisrrylMeíhodoiogy


Ames tests on base lube [lubricating]
The Carcinogenicity of New and Used stocks. (36-33219) T h e Effect of Sampling Duration on the
Lubricants. (30-32847) Concentration of Paniculate Organics
Carcinogenicity Stiidy Collected on [Celman AE] Glass-Fiber
Filiers (28-31614)
Mutagenicity Study The Carcinogenicity of New and Used
Lubricants. (30-32847) Humaii Exposure Assessment
In-Vivo and In-Vitro Mutagenicity Studies.
Paraffinic Oil 79-3, 350 SUS/lOO OF. N-Nitroso Compounds in Airborne Respirable
Final Repori. (28-31865) Mutagenicity Study Particulate Matter. (29-32752)
Mutagenicity Evaluaiion of Petroleum Hydro- Trace Metals in Urban Aerosols. (26-60094)
carbons. (30-31997) in-Vivo and In-Vitro Mutagenicity Studies.
Polynuclear aromatic analyses and modified Paraffinic Oil 78-9.70 SUS/lOO OF. Final Mutageniciry Siudy
Ames tests on base lube [lubricating] Report. (28-3 1864)
stocks. (36-33219) Mutagenicity Evaluation of Peiroleum Hydro- Use of the Ames Assay To Detect Diurnal Va-
carbons. (30-31997) riations in Fractions of Extracted Par-
Polynuclear aromatic analyses and modified ticulate Organic Matter. (29-32827)
Toxicity Study Ames tests on base lube [lubricating]
stocks. (36-33219) PARTICULATES (REVIEW)
The Acute Toxicology of Selected Petroleum
Hydrocarbons. (30-31530) Toxiciry study Toxiciry Study
[Proj.No. 15981 Acute Toxicity Tests, API
79-3, Paraffinic Oil (350 SUS/IOO OF). The Acute Toxicology of Selected Petroleum Ambient Air Quality Standards for Particu-
(29-33067) Hydrocarbons. (30-3 1530) lates...Review and Evaluation. (2640057)

43
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 95 = 0732270 0550003 873 W

Particulates: Air Quality Criiena Based on PETROLEUM ASPHALT Fluid Process Coke. (Petroleum Coking
Health Effects. (26-60058) Sample 6-1-468). A Revised Final Report.
Carcinogetiiciry Siudy (28-30726)
PENTANE
Skin Tuniongenesis in Mice by Petroleum PETROLEUM COKE, LIQUID
Toxicitj Study Asphalts and Coal Tar Pitches of Known CONDENSABLE DELAYED PROCESS,
Polynuclear Aromatic Hydrocarbon QUENCH WATER
Four-Week Oral Nephrotoxicity Screening Content. (26-60122)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Study in Maie F344 Rats [by Bomston Muiagenicity Siiidy


Laboratories Inc.]. Final Report. (32- Epidemiology Sttidy
30966) In-Vivo and In-Vitro Mutagenicity Studies.
A Health Survey of Petroleum Asphalt Quench Water from Delayed Process
n-PENTANE Workers. (26-60093) Coke. Liquid 7-1-100. A Revised Final
Report. (28-30725)
MetabolismlPliarmacokineiics Occiipaiional Health

Studies on the absorption of inhaled hydro- A Health Survey of Petroleum Asphalt PETROLEUM COKE, SOLID
carbon vapors. Final report. (34-33036) Workers. (26-60093) CONDENSABLE DELAYED

Toxicity Srrdy PETROLEUM COKE Muiageiticity St-y

The absence of hydrocarbon-induced nephro- A ~ l y i i c a CliemisrrylMetkodology


l In-Vivo and In-Vitro Mutagenicity Studies.
pathy in rats exposed subchronically to Solid Condensed Emission Product from
volatile hydrocarbon mixtures pertinent to American Petroleum Institute Project Delayed Coke Process. (Petroleum Coking
gasoline (34-30857) PS-22-GRD(840)/ A "Comprehensive Sample 3-1-134). (28-30727)
Thifleen-Week Inhalation Toxicity Study of Analysis of Petroleum Coke Products"
CJC, Hydrocarbon Blends in Rats. Final (28-30724)
Report. (32-31472) Carcinogenic Potential of Petroleum Cokes and PETROLEUM HYDROCARBONS
Process Products - 1. Coking Process and
Sample Characterization. (30-32002) Results of toxicologic studies [of petroleum and
trans-2-PENTENE related materiais] conducted for the
Carcinogenicity Siiidy American Petroleum Institute. (41-30283)
Toxiciv Study
Carcinogenic Potential of Petroleurn Coke and
Four-Week Oral Nephroioxiciiy Screening Process Products. (30-31598) PETROLEUM HYDROCARBONS
Study in Male F344 Rats [by Bomston The carcinogenic potential of petroleum cokes (REVIEW)
Laboratories Inc.]. Final Report. (32- and process products - 2. Bioassay. (30-
30966) 3201 i) Analytical CheniisirylMeihodology

Toxicity Siidy Introduction to Petroleum Hydrocarbons. [An


PERCHLOROETHYLENE (REVIEW) Overview of the] Chemistry and
A two-year inhalation study of petroleum coke Composition in Relation to Petroleum-
Neurotoxicity Study in [I50 male and 150 female Sprague- Derived Fuels and Solvents. (32-01363)
Dawley] rats and [four male and four
Neurotoxicity of organic solvents with special female Cynomolgus] monkeys. (34-32600) Carciiiogeniciry Study
reference to the neurobehavioral effects: A Chronic Inhalation Toxicity Study of Petroleum
[world] literature review (39-30623) Coke (Delayed Process) in Rats and Carcinogenic Potential of Petroleum Hydro-
Monkeys. (32-30234) carbons. A Critical Review of the
Literature (27-30915)
PEROXYACETYL NITRATE PETROLEUM COKE, DELAYED
PROCESS Epidemiology Study
Toxicity Study
Mutagenicity Srudy An Evaluation of the Significance of
A Survey of Eye Irritation and Lachrymation in Experimental Hydrocarbon Toxicity to
Relaiion to Air Pollution (26-60052) In-Vivo and In-Vitro Mutagenicity Studies. Man. (32-30421)
Delayed Process Coke. (Petroleum Coking
Sample 4-1-140). A Revised Final Report. Toxicity Stidy
PETROCHEMICALS (28-30728)
The Renal Effects of Petroleum Hydrocarbons,
Neurotoxicity Study PETROLEUM COKE, FLUID PROCESS 7/18-20/83) (32-01362)
S w p . (BOS~OII
[This Compilation Based on the 1st API - Soc.
An Experimental Evaluation of Selected Petro- Miiiagenicity Study Toxicol. "Toxicol. Pet. Hydrocarbons"
chemicals for Subchronic Neurotoxic Symp. (Wash., D.C. 5/11-13/82)]. (30-
Propeflies. (30-32004) In-Vivo and In-Vitro Mutagenicity Studies. 3 1529)

44

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLa4b34 75 O732290 0550004 70T

PETROLEUM PRODUCTS (REVIEW) PHOSPHORUS (REVIEW) POLYNUCLEAR AROMATIC


HYDROCARBONS (REVIEW)
Review of the Status of Human Community Toxicity Stirdy
Health and Environmental Health Effects Human Exposure Assessment
Research of Pollutants from Coal Phosphonis. (26-60066)
Liquefaction. Oil Shale. and Petroleum Photochemical Smog. (26-60108)
Technologies. A Final Report (29-32809)
POLYCYCLIC AROMATIC PROCESMNc P R O n C C ï S OF CgAI,
PETROLEUM WAX HYDROCARBONS (REVIEW) LIQUEFACTION (REVIEW)

Carcinogenicity Study Aquatic Toxicity Review of the Status of Human Community


Health and Environmental Health Effects
Studies on lhe Toxicity of Petroleum Waxes. Polycyclic Aromatic Hydrocarbons [(PAH)] in Research of Pollutants from Coal
(26-60080) the Aquatic Environment: Sources. Fates, Liquefaction, Oil Shale, and Petroleum
and Biological Effects. (27-32178) Technologies. A Final Report (29-32809)
Toxicify Study
PRODUCED WATER
A 90-day feeding study in the rat with six Carcinogenicity Srudy
different white mineral oils (N15 (H).N70 Human Exposure Assessment
(li ).(A), P15 (H). NI0 (A). and
N70 Polycyclic Aromatic Hydrocarbons [(PAHs)] :
P100 @i), three different mineral waxes (a A Review (28-30174) Produced water radionuclide hazard/nsk
low-melting-point wax. a high-melting- assessment. Phase I. (39-31094)
point wax, and a high-sulphur wax) and
coconut oil. July 1992. (39-32387) Fate and Effects Risk Assessment

PETROLEUM-DERIVED JET Cancerous Diseases in Aquatic Animals and Produced water radionuclide hazard/risk
PROPULSION FUEL Their Association with Environmental assessment. Phase 1. (39-31094)
Pollutants: A Critical Review of the
Neurotoxicity Study Literatu re (32 -32656) PROPANE

Neurobehavioral Toxicology of Petroleum- and Toxicity Study


Shale-Derived Jet Propulsion Fuel No. 5 MetabolismlPkarmacokìtietjcs
(JP5). (30-31533) The Myocardial Toxicity [to Dogs] of Selected
Polycyclic Aromatic Hydrocarbons [(PAHs)] : Aliphatic Hydrocarbons, [Including
Toxicity Study A Review (28-30174) Propane (P), n-Butane, Isobutane, and a
Mixture of These Hydrocarbons (A-46),
Comparison of the Subchronic Inhalation Toxicity Srudy and Mixtures of Isobutane with Methyl
Toxicity of Petroleum and Oil Shale JP-5 Chlorofonn, Trichloroethylene, Methyl
Jet Fuels (30-31534) Polycyclic Aromatic Hydrocarbons [(PAHs)] : Ethyl Ketone, and Methyl Isobutyl
A Review (28-30174) Ketone]. (30-3201 3)
-

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
P E T R O L E U M D ER I VE D M IDDL E
DISTILLATE
POLYMERIZATION NAPHTHA PROPANOL (REVIEW)
Toxicity Study
Toxicity Study Odor and Taste
Renal Cortical Degeneration [of Mice] Asso-
ciated with Chronic Dermal Application of Renal Toxicity of [Vapors of] Gasoline and [A literature] review of published odor
Petroleum- and Shale Oil-Derived Middle Related Petroleum Naphthas in Male Rats. [threshold values (OTVs)] and taste
Distillates. (30-31536) (32-30414) threshold values [('lTVs)] of [lhe 2761
soluble gasoline components (33-30589)
PHENANTHRENE
POLYNUCLEAR AROMATIC PROPYLENE
Fate and Eflects HYDROCARBONS
MetabolisnilP/iarmacokìnetics
Bioaccumulation of polycyclic aromatic hydro.
carbons and metals in estuarine organisms. Studies on the absorption of inhaled hydro-
(40-30741 ) Evaluation of appropriate methodologies for carbon vapors. Final report. (34-33036)
measuring PNA exposures in the
PHENOLICS (REVIEW) petroleum coking environment. (36-30038) RADIONUCLIDES

Aquatic Toxicity Human Exposure Assessment Hitnian Exposure Assessment

Phenolics in Aquatic Ecosystems: A Selected Impact on Human Health of Petroleum in the Produced water radionuclide hazard/risk
Review of Recent Literature. (26-31781) Marine Environment. (32-32651) assessment. Phase I. (39-31094)

45

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLa4634 95 0732290 0550005 6 4 6

Risk Assessment Report. (28-3 1346) F u h e r development and application of an


[Litton Bionetics Inc. Project No. 21141-021 improved population exposure model.
Produced water radionuclide hazard/risk /Mutagenicity Evaluation of Gasoline. API SYSAPP-86/061. (34-32923)
assessment. Phase I. (39-31094) PS-6 Fuel (Unleaded) in the Mouse in Vitro Determination of Chemical
Dominant Lethal Assay. Final Report. (28- Cocarcinogenesis in Balb/c 3T3-A3lSF
REFINED OIL (REVIEW) 3 1344) Cell Cultures. (31-30263)
[Litton Bionetics Inc. Project No. 21 141-031 Lack of Concordance of the Salmonello/ Micro-
Aauatic Toxicity /Mutagenicity Evaluation of Jet Fuel A in some Assay with the Mouse Dermal Car-
the Mouse Dominant Lethal Assay. Final cinogenesis Bioassay for Complex Petro-
Effects of Oil on Aquatic Organisms ...A Report. (28-31345) leum Hydrocarbon Mixtures. (32-31299)
Review of Selected Literature (29-30299) [I-itton Bionetics lnc. Project No. 21 141-OSl Meeting the Quality Assurance Challenges of
/Mutagenicity ixavaiuation of Toluene in the 1980's: Team Auditing by
REPRODUCTIVE EFFECTS the Mouse Dominant Lethal Assay. Final Toxicologists and QA Professionals. (31 -
Report. (28-31347) 32162)
Inhalation Monitoring near refineries for airborne
Dominant lethal assay chemicals on the SARA [(Superfund
A preliminary study of the effect of toluene on Amendments and Reauthorization Act)]
pregnancy [and in utero development] of [Bio/dynamics Inc. Project No. 79-73421 /A Title III Section 313 List-2. A Generic
the rat (inhalation exposure). (40-32425) Dominant-Lethal inhalation Study with Study Design Protocol. (40-30722)
A single-generation inhalation reproduction/ Benzene in Rats [and Effects on Male Statistical Evaluations in the Carcinogenesis
fertility study on a commercial hexane. Reproductive Performance]. (28-3121 I) Bioassay of Petroleum Hydrocarbon. (30-
(33 -32864) [Litton Bionetics Inc. Project No. 21141-03) 3 1983)
A SingleGeneration Inhalation Reproduction/ /Mutagenicity Evaluation of Jet Fuel A in Stimulation and Inhibition of Chemotaxis in
Fertility Study in Rats with Methyl i-Butyl the Mouse Dominant Lethal Assay. Final Abelson Virus-Transformed Macrophages,
Ether (MTBE). (32-30239) Repon. (28-31345) [in Relation to the Clearance of Air
Final Report, April 17, 1991. Commercial [Litton Bionetics Inc. Project No. 21 141-021 Pollutants in the Lung]. (31-30265)
hexane test d e . 40 CFR 799.2155. /Mutagenicity Evaluation of Gasoline, API Teratogenicity testing in vitro: Status of
Two-Generation reproduction study of PS-6 Fuel (Unleaded) in the Mouse validation studies. (34-32774)
inhaled commercial hexane in CD(TM) Dominant Lethal Assay. Final Report. (28- The Occurrence and Natural History of
(Sprague-Dawley) rats. (38-31217) 3 1344) Experimental Skin Tumors. (30-31999)
Final Report, April 17, 1991. Commercial [Litton Bionetics Inc. Project No. 21141-051 The generation and analytical methods devel-
hexane test rule, 40 CFR 799.2155. /Mutagenicity Evaluation of Toluene in opment work for the C, aromatic hydro-
Two-generation reproduction study of the Mouse Dominant Lethal Assay. Final carbms program. Final report. (35-32077)
inhaled commercial hexane in CD(TM) Report. (28-31347) Validation of Behavioral Studies for
(Sprague-Dawley) rats. (38-31216) [Litton Bionetics Inc. Project No. 21141-041 Detemining Neurotoxicity. Final Report.
Inhalation reproduction range-finding study in /Mutagenicity Evaluation of Diesel Fuel in (3 1-31472)
mated rats with C,aromatic hydrocarbons. the Mouse Dominant Lethal Assay. Final Validation of Behavioral Studies for Deter-
Final report. (35-31367) Report. (28-31346) mining the Toxicity of Petroleum
Methyl tertiary butyl ether inhalation in rats: A Hydrocarbons. (30-32063)
single generation reproduction study. (35- RESEARCH METHODOLOGY [A review ofl short-term toxicity tests for
30687) [atmospheric and aqueous] environmental
Parental and Fetal Reproduction Inhalation Tox- A 14 day palatability and stability study in carcinogens and mutagens (34-33031)
icity Study. in Rats, with Mixed Xylenes. mice with benzene administered in
Final Report. [Vol. I & II]. (31-31481) drinking water. (37-32486)
Three generation [(F,, F,, and FI)] reproduction/ A 14 day palatability and stability study in rats RISK ASSESSMENT
fertility study in rats with C, aromatic with benzene administered in drinking
hydrocarbons. (36-32642) water. (37-32485) Dealing with uncettainties in a biologically
Toluene...The effect on pregnancy [and in utero API Exposure Classification Scheme for based risk assessment model of
development] of the rat. (Inhalation collection of industrial hygiene monitoring cyclophosphamide-induced leukemo-
exposure). (40-32426) data. (40-30571) genesis. (41-32131)
Two-Generation Inhalation Reproduction/ API's Approach to Quality Assurance [in API Estimation of incremental benzene exposure
Fertility Study on a Petroleum-Derived Industrial Toxicology Studies]. (30-32064) associated with seven bulk gasoline
Hydrocahon. Toluene [Vol. i]. (32- Dealing with uncertainties in a biologically storage facilities in N o h Carolina. (40-
32854) based risk assessment model of 32761)
(Bio/dynamics Inc. Project No. 79-24251 /An cyclophosphamide-induced leukemo- Produced water radionuclide hazard/risk
Inhalation Female Fertility Study with genesis. (41-32131) assessment. Phase I. (39-31094)
Benzene in Rats. (28-31212) Feasibility Analysis for an Historical
[Bio/dynamics Inc. Project No. 79-73421 /A Prospective Mortality Study of Employees
Dominant-Lethal Inhalation Study with Exposed to Downstream Gasoline in the RUBBER SOLVENT
Benzene in Rats [and Effects on Male Petroleum Industry. Final Report. (32-
Reproductive Performance]. (28-3121 1) 32565) Developmental Eífects
[Litton Bionetics lnc. Project No. 21141-041 Feasibility of Case-Control Studies of Kidney
/Mutagenicity Evaluation of Diesel Fuel in Cancer and Hydrocarbon Exposure among Teratology Study in Rats. Rubber Solvent. Final
the Mouse Dominant Lethal Assay. Final Petroleum Company Workers. (32-32225) Report. (2640015)

46
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*:4634 95 0732290 055000b 5 8 2

Miiiagenicity Study SHALE DUST, S P E h T The Determination of the Carcinogenicity of


[Shale] Retort Oils and Downstream
Estimation of the Mutagenicity of Hydrocarbon Carciiiogeniciry Srudy Products. (30-32849)
Fractions Utilizing the Bacterial Assay
Procedure with Mammalian Tissue A Final Report [on a] 24 Month Inhalation Toxicity Study
Metabolic Activation. API Project PS-4 Toxicity Study of Raw and Spent Shale
#6. (26-60103) Dusts in Rats and Monkeys (27-32466) Twenty-Eight Day Subchmnic Dermal Toxicity
Further Studies of the Mutagenicity of Study in Rats: API-HNC-1 (High-
Hydrocarbon Fractions [by] Utilizing Toxicity Siiuiy Nitrogen, [0.77%], Crude Oil);
Somatic Mutations in Rats. (26-60100) API-SFP-105 (0.05% N, Hydrotreated
Mutagenic Evaluation of Rubber Solvent Long-Tem Inhalation Studies with Raw and Shale Oil): API-SFP-119 (0.19% N,
(CHF-32-263). (26-6001 1 ) Processed [Oil) Shale Dusts. (30-31535) Hydrotreated Shale Oil); API-SFP-206
Mutagenicity Study of Thirteen Petroleum (0.06% N. Hydrotreated Shale Oil);
Fractions. (26-60098) SHALE OIL API-SFR-1 ([1.6% NI. Raw Shale Oil);
API-SFR-2 (12.1% NI, Raw Shale Oil).
Toxicity Study Analyricai ChemistryiMeihoabiogy (32-32652)

Petroleum Hydrocarbon Toxicity S t u d i e s 4 Analysis of Shale Oils and Downstream


Animai and Human Response to Vapors Products. (27-33264) SHALE OIL, IN SITU
of Rubber Solvent. (26-60125) Comprehensive Analysis of Shale Oil Products
(Revised). (26-60063) tt naíylicai CliencistryiMeihodology

RUBBER SOLVENT (FILTERED) SHALE OIL (REVIEW) LAPI Project SPS-5-UOC(858/305)] Compre-
hensive Analyses of Shale Oil Products:
Mutagenicity Srctdy Review of the Status of Human Community Second Study. Final. (28-70300)
Health and Environmental Health Effects
Mutagenic Evaluation of Filtered Rubber Research of Pollumts from Coal
Solvent (CHF-32-263). (26-60016) Liquefaction, Oil Shale, and Petroleuni Carcinogenicity Srctdy
Technologies. A Final Report (29-32809)
The Determination of lhe Carcinogenicity of
SHALE DUST, RAW SHALE OIL, CRUDE [Shale] Retort Oils and Downstream
Products. (30-32849)
Carcinogenicity Stiidy Analyiical CheniistrylMeiliodology

A Final Report [on a] 24 Month Inhalation [API Project SPS-5-UOC(858/305)] Compre- SHALE OIL, RAW
Toxicity Study of Raw and Spent Shale hensive Analyses of Shale Oil Products:
Dusts in Rats and Monkeys (27-32466) Second Study. Final. (28-70300) Carcinogenicify Stiuiy
[Thirty-Day] Dermal Carcinogenesis Study of
Developniental Eficcis Shale-Derived Hydrocarbon Mixtures Lifetime dermal carcinogenesis bioassay of
[(350-550 "F and 550-700 O F ) ] in Mice. shale oil-derived streams in C3H/HeJ
Teratology Studies in Rats. Raw Shale Dust. (32-30626) mice. Final interim report. (33-32009)
Final Report. (26-60007) Slatistical Analyses of Cnide Oil and Shale Oil
Carcinogenicity Siiidy Carcinogenic Test Data. (30-32001)
Toxicity Siid-v
The Determination of the Carcinogenicity of Miriagenicity Study
A Final Report [on a] 24 Month Inhalation [Shale] Retort Oils and Downstream
Toxicity Study of Raw and Spent Shale Products. (30-32849) In vivo sister chromatid exchange assay AP1
Dusts in Rats and Monkeys (27-32466) RO-1 raw shale oil. (37-32484)
Long-Term Inhalation Studies with Raw and SHALE OIL, HYDROTREATED Sister chromatid exchange assay in Chinese
Processed [Oil] Shale Dusts. (30-31535) hamster ovary (CHO) cells: API RO-1,
Teratology Studies in Rats. Raw Shale Dust. A nolvricai Clieniist~iMetliodoiog
y raw shale oil. Final report. (33-30445)
Final Report. (26-60007)
[API Project SPS-5-UOC(858/305)] Compre- Toxicity Siudy
SHALE DUST, RETORTED hensive Analyses of Shale Oil Products:
Second Study. Final. (28-70300) Twenty-Eight Day Subchmnic Dermal Toxicity
Developmental Effects [Thirty-Day] Dermal Carcinogenesis Study of Study in Rats: API-HNC-1 (High-
Shale-Derived Hydrocarbon Mixtures Nitrogen, [0.77%], Crude Oil);
Teratology Study in Rats. Retorted Shale Dust. [(350-550 OF and 550-700 "F)] in Mice. API-SFP-105 (0.05% N. Hydrotreated
Final Report. (26-60008) (32-30626) Shale Oil); API-SFP-119 (0.19% N,
Hydrotreated Shale Oil); APISFP-206
Toxicity Study Carcinogenicity Study (0.06% N. Hydrotreated Shale Oil);
APl-SFR-1 (11.6% NI, Raw Shale Oil);
Teratology Study in Rats. Retorted Shale Dust. Statistical Analyses of Crude Oil and Shale Oil API-SFR-2 ([2.1% NI, Raw Shale Oil).
Final Report. (2640008) Carcinogenic Test Data (30-32001) (32-32652)

47
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 75 0 7 3 2 2 7 0 0550007 4 2 9 9

SHALE OIL, RETORTED SHALE, RAW Interest. (32-30416)


Toxicology of Mixed Distillate and High-
Carcinogenicity Study Analytical ChernistrylMethodology Energy Synthetic Fuels. (32-30415)

The Carcinogenicity of Raw and Spent Oil Comprehensive Analysis of Shale Oil Products SHALE-OIL-DERIVED HEAVY FUEL OIL
Shales and Retort Oils. (29-32356) (Revised). (26-60063) EQUIVALENT HYDROTREATED
The Determination of the Carcinogenicity of RESIDUE
[Shale] Retort Oils and Downstream Carcinogenicity Study
Products. (30-32849) Analytical ChemistrylMeihodology

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
The Carcinogenicity of Raw and Spent Oil
Shales and Retort Oils. (29-32356) [API Project SPS-5-UOC(858/305)] Compre-
Developmental Eflects hensive Analyses of Shale Oil Products:
Mumgenicity Study Second Study. Final. (28-70300)
Teratology Study in Rats. Shale Oil ROI. Finai
Report [on LBI Project No. 20726-Rol]. Mutagenicity Evaluation of Raw Shale. Final Carcinogenicity Study
(27 -32 129) Report. (26-60044)
Teratology Study in Rats. Shale Oil R03. Final Mutagenicity Evaluation of [Raw Shale] The Determination of the Carcinogenicity of
Report [on LBI Project No. 20726R031. RS-101. Final Report. (2660021) [Shale] Retort Oils and Downstream
(27-32 127) Products. (30-32849)
Teratology Study in Rats. Shale Oil R04. Final Toxicity Stuáy
Report [on LBI Project 20726-RO41. (27- SHALE-OIL-DERIVED JET PROPULSION
32128) Acute Toxicity Testing of Shale Oil and FUEL
Process Materials. Final Report. (26-
60027) Neurotoxicity Study
Mutagenicity Study
SHALE, SPENT Neurobehavioral Toxicology of Petroleum- and
Adapting the Ames Salmonella Assay to Shale-Derived Jet Propulsion Fuel No. 5
Complex Hydrocarbon Mixtures. Final Analytical CheniistrylMeihodology (JP5). (30-31533)
Report. (32-32856)
An Evaluation of the Potential of RO-i. 81-15, Comprehensive Analysis of Shale Oil Products Toxicity Study
and PS8-76D5-SAT To Induce (Revised). (26-60063)
Unscheduled DNA Synthesis [(UDS)] in Comparison of the Subchronic inhalation
Primary Rat Hepatocyte Cultures (32- Carcinogenicity Study Toxicity of Petroleum and Oil Shale JP-5
32407) Jet Fuels (30-31534)
An Evaluation of the Potential of RO-I. 81-15, The Carcinogenicity of Raw and Spent Oil Pathologic Findings in Laboratory Animals
and PS8-76DS-SAT T o Induce Shales and Retort Oils. (29-32356) Exposed to Hydrocarbon Fuels of Military
Unscheduled DNA Synthesis [(UDS)] in Interest. (32-30416)
the In Vivo-In Vitro Hepatocyte DNA Toxicify Stuáy Toxicology of Mixed Distillate and High-
Repair Assay (32-32406) Energy Synthetic Fuels. (32-30415)
CHO [(Chinese Hamster Ovary)] /HGPRT Acute Toxicity Testing of Shale Oil and
[(Hypoxanthine-Guanine Phosphonbosyl Process Materials. Final Report. (26- SHALE-OIL-DERIVED MIDDLE
Transferase)] Mammalian Ceii Forward 60027) DISTILLATE
Gene Mutation Assay of API [Sample]
RO-1 Retofled Shale Oil. Final Report. SHALE-OIL-DERIVED DIESEL FUEL Toxicity Study
(32-32744) MARINE
Mutagenicity Evaluation of Petroleum Hydro- Renal Cortical Degeneration [of Mice] Asso-
carbon~.(30-31997) Analytical ChemistryIMeihoabio8y ciated with Chronic Dennal Application of
Mutagenicity Evaluation of Retorted Shale. Petroleum- and Shale Oil-Derived Middle
Final Report. (26-60006) Analysis of Shale Oils and Downstream Distillates. (30-3 1536)
Mutagenicity Evaluation of Six Petroleum Products. (27-33264)
Substances in an In-Vivolln-Vitro Urine [API Project SPS-5-UOC(858/305)] Compre- SOLVENT, 60
Assay. (30-31037) hensive Analyses of Shale Oil Products:
Mutagenicity Evaluation of [Shale Oil] R-01. Second Study. Final. (28-70300) Mutagenicity Study
Draft Report. (26-60004)
Mutagenicity Evaluation of [Shale Oil] R-03. Carcinogenicity Study Estimation of the Mutagenicity of Hydrocarbon
Draft Report. (26-60005) Fractions Utilizing the Bacterial Assay
Mutagenicity Evaluation of [Shale Oil] R-04. The Detemination of the Carcinogenicity of Procedure with Mammalian Tissue
(26-6ooo9) [Shale] Retort Oils and Downstreani Metabolic Activation. API Project PS-4
Products. (30-32849) #6. (26-60103)
Toxicity Study Fuizher Studies of the Mutagenicity of
Toxicity Study Hydrocahcm Fractions [by] Utilizing
Acute Toxicity Testing of Shale Oil and Soniatic Mutations in Rats. (26-60100)
P m s s Materials. Final Report. (26- Pathologic Findings in Laboratory Animals Mutagenic Evaluation of 60 Solvent
60027) Exposed to Hydrocarbon Fuels of Military (CHF-33-148). (26-60003)

48

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API PUBL*4634 75 0732290 0550008 355

Mutagenicity Study of Thirteen Petroleum (35-31936) irritation study in rabbits. Primary eye
Fractions. (26-60098) Human embryonic palatal mesenchyme irritation study in rabbits. Dermal
(HEPM) cell growth inhibition assay [of sensitization study in guinea pigs. Final
Toxicity Study API-86-02 (a dark viscous petroleum report. API 85-01, Stoddard solvent. (CAS
liquid)] (36-31911) 8052-41-3). (33-32723)
Petroleum Hydrocarbon Toxicity Studies--6. Human embryonic palatal mesenchyme Acute inhalation toxicity evaluation of a
Animal and Human Responses to Vapors (HEPM) cell growth inhibition assay [of petroleum-derived h y d r o c a h n in rats.
of "60 Solvent". (26-60084) AP1-86-02 (a dark viscous petroleum API 85-01: Stoddard solvent (CAS
liquid)]...S-9 mediated assay (36-31912) 805241-3). (34-32779)
SOLVENT, 70 Estimation of the Mutagenicity of Hydrocarbon
Mirragenicip Study Fractions Utilizing the Bacterial Assay
Mutagenicity Study Procedure with Mammalian Tissue
Evaluation of API 86-02 (solvent refined coal Metabolic Activation. API Project PS-4
Estimation of the Mutagenicity of Hydrocarbon distillate) in the in-vitro assay for #6. (2660103)
Fractions Utilizing the Bacterial Assay chemical teratogenic potential: inhibition Human Sensory Response to Selected
Procedure with Mammalian Tissue of proteoglycan synthesis. Final repoit. Petroleum Hydrocarbons. (30-32081)
Metabolic Activation. API Project PS-4 (35-3 1936) Petroleum Hydrocarbon Toxicity Studies-3.
#6. (2660103) Mouse ovarian tumor (MOT) cell attachment Animai and Human Response to Vapon
Mutagenicity Study of Thirteen Petroleum assay with API 86-02: Solvent refined of Stoddard Solvent. (2640124)
Fractions. (26-60098) coal distillate. Final report. (35-32481) The Effect of Certain Light Hydrocatùons on
Kidney Function and Structure in Male
Odor and Tasle SOLVENT-REFlNED COAL DISTILLATE Rats. (32-30408)
(REVIEW)
Detectability and Irritability of Hydrocarbons
[Stoddard Solvent and 70 Solvent] in Occrrpalional Heolih STRAIGHT-RUN MIDDLE DISTILLATE
Human Subjecis. Final Report to
American Petroleum Institute. Contract Review of the Status of Biological Aspects of Carcinogenicity SI*
U-15-14-PS-5. (26-60025) Coal Conversion Technology,
Human Sensory Response to Selected 1977-Present. Final Report. (28-31863) Lifetime dennal carcinogenesis/chmic toxicity
Petroleum Hydrocarbons. (30-32081) screening bioassay of [i i] refiery
STODDARD SOLVENT streams in C3HMeJ mice. Twelve-month
Toxicity Stidy toxicity evaluation. (34-32865)
Developmenial Effecu Lifetime dermal carcinogenesis/chronic toxicity
Petroleum Hydrocarbon Toxicity Studies--7. screening bioassay of refinety streams in
[Tests ofl Animal and Human Response to Teratology siudy in Rats. Stoddard Solvent. C3HMeJ mice. niree-month toxicity
Vapors of "70 Solvent" (26-60085) Final Report. (26-60026) evaluation report. Final report. (33-32010)
Twenty-four month dermal carcinogenesis/
SOLVENT. 140' FLASH ALIPHATIC MiriageniciQ Siirdy chronic toxicity screening bioassay of
refinery streams in C 3 W e J mice
Mutagenicity Study Mutagenicity Evaluation of Peiroleum Hydro- (AP-190r). Final Report. (36-33220)
carbons. (30-3 i 997)
Estimation of the Mutagenicity of Hydrocarbon Mutagenicity Evaluation of Stoddard [Solvent] Mittagenicity Study
Fractions Utilizing the Bacterial Assay "Fuel". (26-60010)
Procedure with Mammalian Tissue Mutagenicity Study of Thirteen Petroleum Acute in-Vivo Cytogenetics Assay in Maie and
Metabolic Activation. API Project PS-4 Fractions. (2660098) Female Rats of API 83-1 i. Final Report.
#6. (26-60103) Mutagenicity of API 85-01, Stoddard solvent (32-32408)
Mutagenicity Study of Thirteen Petroleum (CAS 805241-3), in a mouse lymphoma An L5178Y TK+/- Mouse Lymphoma Muta-
Fractions. (26-60098) mutation assay. Final report [by Litton genesis Assay of API 83-11 [(Straight
Bionetics Inc.]. (34-30329) Run Middle Distillate) by Microbiological
Toxicity Siiuíy Associates lnc.] (32-31768)
Odor and Taste Mutagenicity Evaluation of API #83-11 in the
Petroleum Hydrocarbon Toxicity Studies--8. Mouse Lymphoma Fonuard Mutation
Animal and Human Response to Vapors Detectability and Irritability of Hydrocarbons Assay. (32-32166)
of "140" Flash/Aliphatic Solvent". (26- [Stoddard Solvent and 70 Solvent] in Mutagenicity evaluation in the rai bone marrow
60086) Human Subjects. Final Report to cytogenetic assay. API 83-11, straight run
Amencan Petroleum Institute. Contract middle distillate (CAS 64741-44-2). Final
SOLVENT-REFINED COAL DISTILLATE U-15-14-PS-5. (26-60025) repon. (33-30930)

Developmental Effecrs Toxicity Study Toxicity Study

Evaluation of API 86-02 (solvent refined coal A 28-day dermal toxicity study of API 85-01 in 28-Day Demal Toxicity Study in the Rabbit:
distillate) in the in-vitro assay for the rabbit (Stoddard solvent). (36-32640) API 83-11. Straight-Run Middle Distillate
chemical teratogenic potential: Inhibition Acute oral toxicity study in rats. Acute dermal (CAS 64741-44-2). Final Report. (32-
of proteoglycan synthesis. Final repon. toxicity study in rabbits. Primary dermal 32747)

49

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L X 4 6 3 4 95 = 0732290 0550009

Acute Oral Toxicity Study in Rats. Acute SULFATE (REVIEW) SWEETENED NAPHTHA
Dermal Toxicity Study in Rabbits.
Primary Dermal Irritation Study in Toxicity Study
Rabbits. Primary Eye Irritation Study in Carcinogeniciry Sïuúy
Rabbits. Dermal Sensitization Study in Gaseous and Particulate Sulfur Compounds in
Guinea Pigs. API 83-11, Straight-Run Urban Amospheres. (26-60070) Lifetime Dermal Carcinogenesis/Chronic
Middle Distillate (CAS 6474144-2). (32- Microparticulate Sulfates: Effects on Human Toxicity Screening Bioassay of Refinery
32857) Health. (26-60116) Streams in C3H/HeJ Mice. Three-Month
Acute inhalation toxicity evaluation of a Review of Inhalation Toxicology of Sulfuric Toxicity Evaluation Report. [Vol. 1-21,
petroleum-derived h y d r o c a h n in rats, Acid and Sulfates. (26-60024) (32-32653)
API 83-1 1, straight-mn middle distillate Lifetime dermal carcinogenesis bioassay of
(CAS 64741-44-2). Final report. (34- SULF'UR DIOXIDE refinery streams in C3HDie.J mice
30635) (AP-135R). (36-31364)
Lifetime dermal carcinogenesis/chronic toxicity Toxicity Siudy Lifetime dermal carcinogenesis/chronic toxicity
screening bioassay of [ i l ] refinery screening bioassay of refinery streams in
streams in C3H/HeJ mice. Twelve-month Effects of Sulfur Dioxide on Human Subjects C3HMe.l mice. Twelve-month toxicity
toxicity evaluation. (34-32865) Exhibiting Peripheral Airway Impairment evaluation report. Final report. [Vol. 1-31,
Lifetime dermal carcinogenesis/chronic toxicity (26-60023) (33-31451)
screening bioassay of refinery streams in Further Investigation on the Effects of Sulfur Short-term dermal tumorigenesis study of selec-
C3HMe.J mice. ïñree-month toxicity Dioxide on Human Subjects. (2640022) ted petroleum hydrocarbon [processing
evaluation report. Final report. (33-32010) Study of Synergistic Effects of Certain Airborne fractions] in male CD-1 mice. Initiation
Twenty-four month dermal carcinogenesis/ Systems in the Cynomolgus Monkey. (27- and promotion phases. (36-32643)
chronic toxicity screening bioassay of 30704)
refinery streams in C3H/HeJ mice The hng-Term Effects of Sulfur Dioxide on
(AP-190r). Final Report. (36-33220) Ciliary Activity in the Trachea (26- Muiagenicity Study
60071)

STYRENE (REVIEW) SULFUR DIOXIDE (REVIEW) Mutagenicity evaluation in the rat bone marrow
cytogenetic assay. API 81-08, sweetened
Hunwn Exposure Assessment Toxicity Srudy naphtha (CAS 64741-87-3). Final report
[by Litton Bionetics Inc.]. (33-31093)
Use of biological monitoring and biomarkers. A Unified Approach to the Use of Human [A Final Report by Litton Bionetics Inc. on]
State-of-the-art review. (40-32427) Clinical Data: A Case Study of Nitrogen Mutagenicity Evaluation Studies in the
Dioxide and Suifur Dioxide. (32-32502) Mouse Lymphoma Forward Mutation
Neuroïoxicity Stidy Facts and Opinions on the Role of Sulfur Assay [with] Sweetened Naphtha. [API]
Dioxide in Causing Injury [to Human Sample 81-08. (32-31233)
Neurophysiological and Psychological Disorders Health]. (26-60095)
and Occupational Exposure to Organic Gaseous and Particulate Sulfur Compounds in
Solvents. (31-32980) Urban Atmospheres. (2640070) Toxicity Sïuày
Neurotoxicity of organic solvents with special Microparticdate Sulfates: Effects on Human
reference to the neurobehavioral effects: A Health. (26-60116)
[world] literature review (39-30623) Response of Specific Airways Resistance Acute Toxicity Studies of Sweetened Naphiha,
(SRaw) to SO, in the Exercising [API] Sample 81-08. (30-31990)
SULFATE Asthmatic: Dose Considerations. (32- LC, acute inhalation toxicity evaluation of a
32461) petroleum-derived h y d m a h n in rats.
Cardiopulmonary API 81-08. sweetened naphtha (CAS
SULFURIC ACID 64741 -87-3). Final report [by International
Effects of Sulfate Aerosols upon Research & Development Coip.]. (33-
Cardiopulmonary Function in Squirrel Human Exposure Assessment 3 1827)
Monkeys. Report of Second Year's Work Lifetime Dermal CarcinogenesislChronic
under APRAC Project CAPM-20-74. (26- Monitoring near refineries for airborne chemical Toxicity Screening Bioassay of Refinery
a 9 ) on the SARA [(Superfund Amendments Streams in C3HMeJ Mice. Three-Month
and Reauthorization Act of 1986)] Title Toxicity Evaluation Report. [Vol. i -21.
Toxicity Study III Section 313 list. Volume ¡...Validated (32-32653)
ambient air concentrations around three Lifetime dermal carcinogenesis/chronic toxicity
Effects of Nitrate and/or Sulfate Aerosols upon refineries. (36-32657) screening bioassay of refinery streams in
Cardiopulmonary Function. Final Report C3HMeJ mice. Twelve-month toxicity
[for First Year of Project]. (27-30842) evaluation report. Final report. [Vol. 1-31.
Effects of Sulfate Aerosols upon Human SULFURIC ACID (REVIEW) (33-31451)
Pulmonary Function. CRC APRAC [A Hazleton Laboratories America Inc.] Dermal
Project CAPM-27-75. (27-30841) Toxicity Study Sensitization Study in Guinea Pigs [by
Effects of Sulphate Aerosols upon Human the] Closed Patch Technique [with the
Cardiopulmonary Function. CRC APRAC Microparticulate Sulfates: Effects on Human Use ofl Sweetened Naphtha, API Sample
Project CAPM-27-75. (27-30839) Health. (26401 16) 8 1-08. (3 1-3135I )

50
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLs4b34 95 = 0 7 3 2 2 9 0 0550010 TO3

TAME Mutagenicity Study of Thirteen Petroleum (HEPM) cell growth inhibition assay.3-9
Fractions. (26-60098) mediated assay [with toluene] ...Final
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Odor and Taste report. (37-30620)


Toxicity Study Mouse ovarian tumor (MOT) cell attachment
Odor and taste threshold studies performed with assay with toluene. (37-31 150)
tertiary-amyl methyl ether (TAME). (40- Petroleum Hydrocarbon Toxicity Studies.. 10. Teratology Study in Rats. Toluene. Final
06424) [On the Basis of] Animal and Human Report. (2660019)
Odor threshold studies performed with gasoline Response to Vapors of "50 Thinner". (26- Toluene...The effect on pregnancy [and in utero
and gasoline combined with MTBE, 60088) development] of the rat. (inhalation
ETBE, and TAME. (41-01257) exposure). Toxicology Report Number
THINNER, 80 TR401, June 1993. (40-32426)
Toxicity Study Two-Generation Inhalation Reproduction/
Mutugenicity Study Fertility Study on a Petroleum-Derived
Closed-patch repeated insult dermal sensitiza- Hydrocarbon, [¡.e..] Toluene [Vol. 11. (32-
tion study of tertiary amyl methyl ether Estimation of the Mutagenicity of Hydrocarbon 32854)
VAME) in guinea pigs (Buehler method). Fractions Utilizing the Bacterial Assay
(41-05416) Procedure with Mammalian Tissue Human Exposure Assessment
Metabolic Activation. API Project PS-4
2,2,3J*TETRAMETHY LBüTANE #6. (26-60103) Exposure data on C, and C, aromatics during
Mutagenicity Study of niirteen Petroleum handling and production of motor
MetobolismlPharmacokinetics Fractions. (26-60098) gasolines. (33-31598)
Monitoring near refineries for airborne chemical
Studies on the absorption of inhaled hydro- Toxicify Study on the SARA [(Superfund Amendments
c a h vapors. Final report. (34-33036) and Reauthorization Act of 1986)] Title
Petroleum Hydrocarbon Toxicity Studies-9. III Section 313 list. Volume LValidated
2,2,4,4-TETRAMETHY LDECANE Animal and Human Response to Vapors ambient air concentrations around three
of "80 Thinner". (26-60087) refineries. (36-32657)
Toxicity Study
TIN (REVIEW)
Final Report. A four-week orai nephrotoxicity
screening study in male -44 rats (33- Toxicity Study Absorption of petroleum products across the
31097) skin of monkey and man. Final report.
Tin. (26-60069) (37 -31827)
2,2,4,J,-TETRAMETHY LOCTAKE Absorption of petroleum products across the
TOLUENE skin of the monkey and miniature pig.
Tuxicity Study Annual report (Mar. 15, 1979-Mar. 14,
Behavioral Study 1980). (33-31034)
Final Report. A four-week oral nephrotoxicity
screening study in male F344 rats (33- Behavioral Evaluation of Petroleum Mutagenicity Study
31097) H y d r o c a b s . (30-32836)
Evaluation of toluene in the in-vitro assay for
Carcinogenicity Study chemical teratogenic potential: inhibition
THINNER, 40 of proteoglycan synthesis. Final report.
Lifetime dermal carcinogenesis bioassay of (35-31939)
Mutagenicity Study refinery streams in C3HMeJ mice Mouse ovarian tumor (MOT)cell attachment
(AP-135R). (36-31364) assay with toluene. (37-31 150)
Mutagenicity Study of Thirteen Petroleum Twenty-four month dermal carcinogenesis/ Mutagenicity Evaluation of Toluene. (2660020)
Fractions. (26-60098) chronic toxicity screening bioassay of Mutagenicity Study of Thirteen Petroleum
refinery streams in C3HRle.J mice (AP- Fractions. (26-60098)
Toxicity Stiidy 190r). Final Report. (36-33220) [Litton Bionetics Inc. Project No. 21141-051
/Mutagenicity Evaluation of Toluene in
Petroleum Hydrocarbon Toxicity Siudies--12. Developniental Effects the Mouse Dominant Lethal Assay. Final
Animal and Human Response to Vapors Report. (28-31347)
of "40" Thinner (26-60090) A preliminary study of the effect of toluene on
pregnancy [and in utero development] of Neirrotoxicity Study
THINNER, 50 the rat. (Inhalation exposure). (40-32425)
Evaluation of toluene in the in-vitro assay for An Experimental Evaluation of Selected
Mutagenicity Stiidy chemical teratogenic potential: Inhibition Petrochemicals for Subchronic Neurotoxic
of proteoglycan synthesis. Final report. Properties. (30-32004)
Estimation of the Mutagenicity of Hydrocarbon (35-3 1939) Effects of Toluene Exposure on Auditory
Fractions Utilizing the Bacterial Assay Human embryonic palatal mesenchyme Pathways. Final Report. (31-32169)
Procedure with Mammalian Tissue Meta- (HEPM) cell growth inhibition assay [with Neurobehavioral Effects of Subchronic
bolic Activation. API Project PS-4 #6. toluene] ...Final report. (37-3061 8) Exposure of Weanling Rats to Toluene or
(26-601 03) Human embryonic palatal mesenchyme Hexane. (30-32008)

51

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL+4634 95 0732290 0550011 9 4 T m

Toluene-Induced Hearing Loss in Rats TOXICITY STUDY A (28-Day Dermal Toxicity Study of API
E v i d e n c e d by t h e B r a i n s t e m [Vacuum Residuum] Sample 81-14 in the
Auditory-Evoked Response [(BAER)]. Dermal Rabbit (30-32853)
(30-32077) A Dermal Sensitization Study [by Hazleton
Transient cognitive deficits and high-frequency 28-day dermal toxicity study in the rabbit: API Laboratones America Inc.] in [SO] Guinea
hearing loss in weanling rats exposed to 83-09 straight run kerosine (CAS Pigs [by the] Closed Patch Technique
toluene. (30-32009) 8008-20-6). Final repon. (33-30443) [with the Use ofl API Sample 8 1 4 3 (31-
28-day dermal toxicity study in the rabbit: API 31412)
83-12 hydrotreated light naphthenic A Dermal Sensitization Study in 1501 Guinea
Reproductive Eflecîs distillate (CAS 64742-536). Final report. Pigs [by the] Closed Patch Technique
(33-30499) [with the Use ofl API Sample 81-07
A preliminary study of the effect of toluene on 28-day dermal toxicity in the rabbit. API 84-02. [(Hydrodesulfurized Kerosine)]. (31-
pregnancy [and in utero development] of heavy thermally cracked naphtha (CAS 31413)
the rat. (Inhalation exposure). (40-32425) 64741-83-9). Final report [by Tegeris Acute oral toxicity study in rats. Acute dermal
Toluene...The effect on pregnancy [and in utero Laboratories Inc.]. (33-31696) toxicity study in rabbits. Primary dermal
development] of the rat. (inhalation 28-day dermal toxicity study in the rabbit: API irritation study in rabbits. Primary eye
exposure). Toxicology Report Number 83-19. light alkylate naphtha (CAS irritation study in rabbits. Dermal sensiti-
TR401, June 1993. (40-32426) 64741-66-8). Final report. (33-30498) zation study in guinea pigs. Final report.
Two-Generation Inhalation Reproduction/ 28-Day dermal toxicity study in the rabbit b y API 83-20, light catalytic cracked naphtha
Fertility Study on a Petroieuni-Derived Tegeris Laboratories Inc.]. API 81-04, (petroleum) (CAS 64741-55-5). (33-
Hydrocarbon. [¡.e.,] Toluene [Vol. i]. (32- light catalytically cracked naphtha (CAS 32722)
32854) 64741-55-5). Final report. (33-30747) Acute oral toxicity study in rats. Acute dermal
[Liiion Bionetics Inc. Project No. 21141-051 28-Day dermal toxicity study in the rabbit [by toxicity study in rabbits. Primary dermal
/Mutagenicity Evaluation of Toluene in Tegeris Laboratones Inc.]. API 83-04. irritation study in rabbits. Primary eye
the Mouse Dmiinant Lethal Assay. Final light catalytically reformed naphtha (CAS irritation study in rabbits. Dermal
Report. (28-31347) 64741-63-5). Final report. (33-30597) sensitization study in guinea pigs. Final
28-Day dermal toxicity study of API 83-15, report. API 85-01, Stoddard solvent. (CAS
hydrotreated heavy naphthenic distillate 8052-4 1-3). (33 -32723)
Taricin, Srudy (CAS 64742-52-5). in the rabbit. Final Acute oral toxicity study in rats. Acute dermal
report. (35-32430) toxicity study in rabbits. Primary dermal
Four-Week Oral Nephrotoxicity Screening 28-Day dermal toxicity study in the rabbit. API irritation study in rabbits. Primary eye
Study in Male F344 Rats [by Borriston 83-16, light paraffinic distillate solvent irritation study in rabbits. Dermal
Laboratories Inc.]. Final Report. (32- extract (CAS 64742-05-8). Final repon sensitization study in guinea pigs. API
30966) [by Tegeris Laboratories Inc.]. (33-31695) 83-15, hydrotreated heavy naphthenic
Petroleum Hydrocarbon Toxicity Studies--13. 28-Day Dermal Toxicity Study in the Rabbit: distillate (CAS 64742-52-5). Final report
Animal and Human Response to Vapors API 83-1 1. Straight-Run Middle Distillate [by Hazleton Laboratories America Inc.].
of Toluene Concentrate. (26-60091) (CAS 64741-44-2). Final Repon. (32- (33-32639)
[Bio/dynamics Inc. Project No. 78-72341 /A 32747) Acute oral toxiciiy study in rats. Acute dermal

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
(26- Week Inhalation Toxicity Study of A 28-day dermal toxicity study of API 85-01 in toxicity study in rabbits. Primary dermal
Toluene in the Rat. (28-31210) the rabbit (Stoddard solvent). (36-32640) irritation study in rabbits. Primary eye
A 28-Day Dermal Toxicity Study of API irritation study in rabbits. Dermal
Vacuum Residuum Sample 81-13 in the sensitization study in guinea pigs. API
TOLUENE (REVIEW) Rabbit. (30-32852) 83-16. light paraffinic distillate solvent
A 28-Day Dermal Toxicity Study in the Rabbit. extract (CAS €4742-05-8). (33-31226)
Aquatic Toxiciîy API 83-08. Light Catalytically Cracked Acute oral toxicity study in rats. Acute dermal
Distillate (CAS 64741-59-9). (32-32753) toxicity study in rabbits. Primary dermal
Benzene, Xylene, and Toluene in Aquatic A 28-Day Dermal Toxicity Study in the Rabbit initation study in rabbits. Primary eye
Systems: A Review (27-32296) of API [Sample] 83-07, a Light irritation study in rabbits. Dermal
Catalytically Cracked Distillate (CAS sensitization study in guinea pigs. API
Human Exposure Assessment 64741-59-9). Final Report. (32-32751) 83-19, light alkylate naphtha (CAS
A 28-Day Dermal Toxicity Study in the Rabbit. 6474166-8). Final report. (33-30594)
Use of biological monitoring and biomakers. API 83-18. Heavy, Catalytically Cracked Acute oral toxicity study in rats. Acute dermal
State-of-the-art review. (40-32427) Naphtha (CAS 64741-54-4). Final Report. toxicity study in rabbits. Primary dermal
(32-32748) irritation study in rabbits. Primary eye
Neuroroxicity Siudy A 28-Day Dermal Toxicity Study in the Rabbit. irritation study in rabbits. Dermal
API [Sample] 83-06, Heavy Catalytically sensitization study in guinea pigs. API
A Tale of Two Solvents: The Neurology of Reformed Naphtha (CAS 64741-68-0). 83-18, heavy catalytically cracked naphtha
n-Hexane and Toluene. (30-32079) Final Report. (32-32752) (CAS 64741-54-4). Final report. (33-
Neurophysiological and Psychological Disorders A 28-Day Dermal Toxicity Study of API 30593)
and Occupational Exposure to Organic [Catalytic Cracked Clarified Oil] Sample Acute oral toxicity study in rats. Acute dermal
Solvents. (31-32980) 81-15 in the Rabbit. (30-32854) toxicity study in rabbits. Primary dermal
Neurotoxicity of organic solvents with special A 28-Day dermal toxicity study of API 83-20 irritation study in rabbits. Primary eye
reference to the neumbehavioral effects: A [clear liquid test anicle] in the rabbit (37- irritation study in rabbits. Dermal
[world] literature review (39-30623) 31958) sensitization study in guinea pigs.

52

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 - 0 7 3 2 2 9 0 0 5 5 0 0 3 2 886

API 84-01. light paraffinic distillate (CAS Catalytically Reformed Naphtha (CAS in rats: API 81-15, catalytically cracked
64741-50-0). Final report. (33-30595) 64741-68-0). (32-32860) clarified oil (CAS 64741-62-4). Final
Acute oral toxicity study in rats. Acute dermal Acute Toxicity Studies of Catalytically Cracked report. (33-30442)
toxicity study in rabbits. Primary dermal Clarified Oil, API Sample 81-15. (30- Lifetime dermal carcinogenesis/chronic toxicity
irritation study in rabbits. Primary eye 3 1854) screening bioassay of refinery streams in
irritation study in rabbits. Dermal sensiti- Acute Toxicity Studies [by Hazleton Raltech C3HMe.l mice. Twelve-month toxicity
zation study in guinea pigs. API 83-12. Inc.] of Hydrodesulfurized Kerosine, evaluation report. Final report. [VOL 1-31,
hydrotreated light naphthenic distillate [API] Sample 81-07. (30-31986) (33-31451)
(CAS 64742-53-6). Final report. (33- Acute Toxicity Studies of Sweetened Naphtha, Lifetime dermal carcinogenesis/chronic toxicity
30592) [API] Sample 81-08. (30-31990) screening bioassay of refinery streams in
Acute oral toxicity study in rats. Acute dermal Acute Toxicity Studies of Vacuum Residuum, C3HMe.l mice. 'Ihree-month toxicity
toxicity study in rabbits. Primary demial [API] Sample 81-14. (30-31989) evaluation repon. Final repon. (33-32010)
irritation study in rabbits. Primary eye Acute Toxicity Studies [by Hazieton Raltech Lifetime dermal carcinogenesis/chronic toxicity
irritation study in rabbits. Dermal sensiti- Inc. ofl Hydrodesulfurized Middle screening bioassay of [li] refmery
zation study in guinea pigs. API 83-07, Distillate, [API] Sample 81-10. (30-32348) streams in C3WHeJ mice. Twelve-month
light catalytically cracked distillate (CAS Acute Toxicity Studies [by Hazleton Raltech toxicity evaluation. (34-32865)
64741-59-9). (33-30162) Inc. ofl Hydrodesuüurized Middle Lifetime Dermal Carcinogenesis/Chronic
Acute oral toxicity study in rats. Acute dermal Distillate, [API] Sample 81-09. (30-32347) Toxicity Screening Bioassay of Refmery
toxicity study in rabbits. Primary dermal Acute Toxicity Studies of Light Catalytically Streams in C3HMeJ Mice. Three-Month
initation study in rabbits. Primary eye Cracked Naphtha. [API] Sample 81-03. Toxicity Evaluation Report. [Vol. 1-21.
irritation study in rabbits. Dermal sensiti- (30-31988) (32-32653)
zation study in guinea pigs. API 84-02, Acute Toxicity Studies of Vacuum Residuum. Renal Cortical Degeneration [of Mice] Asso-
heavy thermally cracked naphtha (CAS [API] Sample 81-13. (30-31987) ciated with Chronic Dermai Application of
64741-83-9). Final report. (33-30596) Acute Toxicity Testing of Shale Oil and Petroleum- and Shale Oil-Derived Middle
Acute Oral Toxicity Study in Rats, Acute Process Materials. Final Report. (26- Distillates. (30-31536)
Dermal Toxicity Study in Rabbits. 60027) T h e Acute Toxicology of Selected Petroleum
Primary Dermal Irritation Study in Closed-patch repeated insult dermal Hydrocarbons. (30-31530)
Rabbits, [and] Primary Eye Initation sensitization study of tertiary amyl methyl Thirteen Week Dermai Toxicity Study of a
Study in Rabbits of API 81-04. Light ether (TAME) in guinea pigs (Buehler Petroleum-Derived Hydrocarbon in Rats:
Catalytically Cracked Naphtha. (32-31708) method). (41-05416) (API 81-15) Catalytically Cracked
Acute Oral Toxicity Study in Rats, Acute Dermal sensitization study in guinea pigs [by Clarified Oil (CAS 64741-62-4). Final
Dermal Toxicity Study in Rabbits, Pri- Hazleton Laboratories America Inc.] : API Repon. (32-32743)
mary Dermal Irritation Study in Rabbits, 83-04 light catalytically reformed naphtha Twenty-eightday dermal toxicity study in the
and Primary Eye Imtation Study in (CAS 64741-63-5). Final report. (33- rabbit. API 84-01. light paraffinic distillate
Rabbits of API 83-04 Light Catalytically 30496) (CAS 64741-50-0). Final repon [by
Reformed Naphtha. (32-31473) Dermal sensitization study in guinea pigs [by Tegeris Laboratories Inc.]. (33-31642)
Acute Oral Toxicity Study in Rats. Acute Hazleton Laboratories America Inc.] : API Twenty-Eight-Day Dermal Toxicity Study in
Dermal Toxicity Study in Rabbits. Pri- 83-05 full-range catalytically cracked the Rabbit of Hydrodesulfurized Middle
mary Dermal Irritation Study in Rabbits. reformed naphtha (CAS 68955-35-1). Distillate, [API] Sample 81-10. [by
Primary Eye Imtation Study in Rabbits. Final report. (33-30497) Borriston Laboratories Inc.]. Final Report.
Dermal Sensitization Study in Guinea Dermal sensitization study in guinea pigs [by (30-32296)
Pigs. API 83-08. Light Catalytically Hazleton Laboratories America Inc.] : API Twenty-Eight Day Subchronic Dermal Toxicity
Reformed Distillate (CAS 64741-59-9). 81-04 light catalytically cracked naphtha Study in Rats: API-HNC-I (High-
(32-32859) (CAS 64741-55-5). Final report. (33- Nitrogen. [0.77%]. Crude Oil);
Acute Oral Toxicity Study in Rats. Acute 30495) API-SFP-105 (0.05% N. Hydrotreated
Dermal Toxicity Study in Rabbits. Pri- Dermal Sensitization Study in Guinea Pigs. Shale Oil); API-SFP-I19 (0.19% N,
mary Dermal Irritation Study in Rabbits. Closed Patch Technique. Hydrotreated Shale Oil); API-SFP-206
Primary Eye Irritation Study in Rabbits. Hydrodesulfurized Middle Distillate, API (0.06% N, Hydrotreated Shale Oil);
Dermal Sensitization Study in Guinea Sample 81-09. (31-31352) API-SFR-1 (11.6% NI, Raw Shale Oil);
Pigs. API 83-09. Straight Run Kerosine Dermal Sensitization Study in Guinea Pigs. API-SFR-2 (12.1% NI, Raw Shale Oil). --``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

(CAS 8008-20-6). (32-32858) Closed Patch Technique. (32-32652)


Acute Oral Toxicity Study in Rats. Acute Hydrodesulfurized Middle Distillate, API Twenty-Eight-Day Dermal Toxicity Study in
Dermal Toxicity Study in Rabbits. Pri- Sample 81-10. (31-31414) the Rabbit of Hydrodesulfurized Middle
mary Dermal Irritation Study in Rabbits. Dermal Sensitization Study in Guinea Pigs. Distillate, [API] Sample 81-09. Final
Primary Eye Irritation Study in Rabbits. Closed Patch Technique. Vacuum Report. (30-32298)
Dermal Sensitization Study in Guinea Residuum. API Sample 81-13. (31-31415) Twenty-Eight-Day Dermal Toxicity Study in
Pigs. API 83-11, Straight-Run Middle Dermal Sensitization Study in Guinea Pigs. the Rabbit of Hydrodesulfurized Kerosine,
DistiUate (CAS 64741-44-2). (32-32857) Closed Patch Technique. Catalytic [API] Sample 81-07. Final repon. (30-
Acute Oral Toxicity Study in Rats. Acute Cracked Clarified Oil, API Sample 81-15. 32297)
Dermal Toxicity Study in Rabbits. (31-31417) Twenty-four month dermal carcinogenesis/
Primary Demal Irritation Study in Dermal Sensitization Study in Guinea Pigs. chronic toxicity screening bioassay of
Rabbits. Primary Eye Irritation Study in Closed Patch Technique. Vacuum refinery streams in C3H/HeJ mice
Rabbits. Dermal Sensitization Study in Residuum, APl Sample 81-14. (31-31416) (AP-190r). Final Report. (36-33220)
Guinea Pigs. API 83-06. Heavy Four-week dermal range-finding toxicity study [A Hazleton Laboratories America Inc.] Dermal

53

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*:4634 95 0 7 3 2 2 9 0 0550033 7 1 2

Sensitization Study in Guinea Pigs [by [Project No. 16011 Acute Toxicity Tests of API Acute inhalation toxicity evaluation of a
the] Closed Patch Technique [with the 78-9. Paraffinic Oil (70 SUS/lOO OF). (29- petroleum-derived hydrocarbon in rats.
Use ofl Sweetened Naphtha, API Sample 33104) API 84-02: Heavy thermal cracked
81-08. (31-31351) [Project No. 16021 Amie Toxicity Tests of API naphtha (CAS 64741-83-9). (34-32778)
[A Tegeris Laboratories Inc.] (28--day dermal 78-10, Paraffinic Oil (150 SUS/100 O F ) . Acute inhalation toxicity evaluation of a
toxicity study in the rabbit. API 83-05 full (29-33105) petroleum-derived hydrocarbon in rats,
range catalytically reformed naphtha (CAS [Project No. 16161 Acute Toxicity Tests of API API 83-19, light alkylate naphtha (CAS
68955-35-1). [This] final report (33- 78-5, Naphthenic Oil (150 SUS/100 O F ) . 64741-66-8). Final report. (34-30636)
30598) (29-33106) Acute Inhalation Toxicity Evaluation of a
[Hazleton Laboratories America Inc.'s] Acute Petroleum-Derived Hydrocahon in
Oral Toxicity Study in Rats, Acute Rats...Light Catalytic Cracked Naphtha.
Dermal Toxicity Study in Rabbits, Inlialotion API Sample 81-04. (31-30680)
Primary Dermal Irritation Study in Acute Inhalation Toxicity Evaluation of a
Rabbits, and Primary Eye Irritation Study A Chronic Inhalation Study with Unleaded Petroleum-Derived Hydrocarbon in Rats.
in Rabbits of API 83-05 Full Range Gasoline Vapor. (32-32227) Light Catalytic Reformed Naphtha ...API
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Catalytically Reformed Naphtha. (32- A Final Report [on a] 24 Month Inhalation Sample 83-04. (31-30613)
31474) Toxicity Study of Raw and Spent Shale Acute Inhalation Toxicity Evaluation of a
[Project No. 14431 /Acute Toxicity Tests of Dusts in Rats and Monkeys (27-32466) Petroleum-Derived Hydrocahon in
API #78-2 No. 2 Home Heating Oil ( 3 0 4 A Nine Day Inhalation Toxicity Study of Rats ...Full-Range Catalytic Reformed
Cat) (27-32771) Methyl t-Butyl Ether in the Rat. (32- Naphtha. API Sample 83-05. (31-30681)
[Project No. 14431 /Acute Toxicity Tests...API 30235) Acute Inhalation Toxicity Evaluation of a
79-6 Diesel Fuel (Marketplace Sample). A thirteen week inhalation toxicity study of Petroleum-Derived Hydrocarbon in Rats.
(27-32817) commercial hexane in the rat and mouse API #83-06. Heavy Catalytically
[Project No. 1443) /Acute Toxicity Tests...API (37-31151) Reformed Naphtha. Final Report. (32-
79-7 Used Composite Motor Oil. (27- A Twelve-Week Inhalation Toxicity Study of 32169)
32772) Benzene on Seven Species of Animals. Chronic Benzene Toxicology. Final Report.
[Project No. 14431 /Acute Toxicity Tests of Final Report. (27-30765) (29-32358)
API 78-7 No. 6 Heavy Fuel Oil (17.1 A two-year inhalation study of petroleum coke Chronic Gasoline Toxicity [Tests on Laboratory
"API/O.8% S) (27-32774) in [i50 male and 150 female Sprague- Animals]. (30-3 1991)
[Project No. 1443) /Acute Toxicity Tests [on] Dawley] rats and [four male and four Chronic Inhalation Toxicity Study of Petroleum
API #78-4. No. 2 Home Heating Oil (50% female Cynomolgus] monkeys. (34-32600) Coke (Delayed Process) in Rats and
Cat) (27-32068) Acute inhalation toxicity evaluation in rats: API Monkeys. (32-30234)
[Project No. 14431 /Acute Toxicity Tests [of] 83-07, light catalytically cracked distillate Comparison of the Subchronic Inhalation
API #78-1. New Composite Motor Oil. (CAS 64741-59-9). Final report. (33- Toxicity of Petroleum and Oil Shale JP-5
(27 -32 131) 30549) Jet Fuels (30-31534)
[Project No. 14431 /Acute Toxicity Tests of Acute inhalation toxicity evaluation of a D u r a t i o n of [ H u m a n ] P u l m o n a r y
API 1178-3 No. 2 Home Heating Oil (10% petroleum-derived hydrocarbon in rats, Hyperresponsiveness to Acute Ozone
Cat) (27-32773) API 83-09, straight-run kerosine (CAS Exposure. Final Report. (32-31232)
[Project No. 14431 /Acute Toxicity Tests of 8008-20-6). Final report. (34-30634) Effects of Nitrate and/or Sulfate Aerosols upon
API Jet Fuel A (27-32815) Acute inhalation toxicity evaluation of a Cardiopulmonary Function. Final Report
[Project No. 14431 /Acute Toxicity Tests of petroleum-derived hydrocarbon in rats. [for First Year of Project]. (27-30842)
API 79-2 No. 6 Heavy Fuel Oil (5.2 API 83-20: Light catalytic cracked Effects of Oxidant Levels on Selected Health
"AP1/1.2% S) (27-32813) naphtha (CAS 64741-55-55). (34-32777) Characteristics of Persons in the Los
[Project No. 14431 /Acute Toxicity Tests...API Acute inhalation toxicity evaluation of a Angeles Basin. First Annual Report.
78-6 No. 6 Heavy Fuel Oil (11.7 petroleum-derived hydrocarbon in rats, Volume 1. Data Collection. (2660079)
OAPI/2.7% S). (27-32814) API 83-1 1. straight-run middle distillate Effects of Oxides of Nitrogen, Carbon
[Project No. 14431 /Acute Toxicity Tests [ofl (CAS 6474144-2). Final report. (34- Monoxide and Photochemical Oxidants on
API #PS-6. Unleaded Motor Gasoline (27- 30635) the [Electrocardiogram] during Exercise
32130) Acute inhalation toxicity evaluation in rats: API and on Cardiopulmonary Function. Finai
[Project No. 14431 /Acute Toxicity Tests...API 83-08. light catalytically cracked distillate Repon (APRAC Project CAPM-21-74).
78-8 No. 6 Heavy Fuel Oil (23.1 (CAS 64741-59-9). Final report. (33- (2640045)
"API/0.2% S). (27-32816) 30444) Effects of Sulfate Aerosols u p Human
[Project No. 15971 Acute Toxicity Tests of API Acute inhalation toxicity evaluation of a Pulmonary Function. CRC APRAC
79-1. Naphthenic Oil (90 SUSRIO OF). petroleum-derived hydrocarbon in rats. Projeci CAPM-27-75. (27-30841)
(29-33065) API 85-01: Stoddard solvent (CAS Effects of Sulfur Dioxide on Human Subjects
[Project No. 15981 Acute Toxicity Tests. API 8052-41-3). (34-32779) Exhibiting Peripheral Airway Impairment
79-3. Paraffinic Oil (350 SUS/IOO OF). Acute inhalation toxicity evaluation of a (26-60023)
(29-33067) petroleum-derived hydrocarbon in rats. Effects of Sulphate Aerosols upon Human
[Project No. 15991 Acute Toxicity Tests of API API 83-18: Heavy catalytic cracked Cardiopulmonary Function. CRC APRAC
7 9 4 , Paraffinic Oil (550 SUS/IOO OF). naphtha (CAS 64741-54-4). (34-32776) Project CAPM-27-75. (27-30839)
(29-33066) Acute inhalation toxicity evaluation of a Experimental Human Exposure to Carbon
[Project No. 16001 Acute Toxicity Tests, API petroleum-derived hydrocarbon in rats. Monoxide [at Concentrations of < 1, 25,
79-5, Paraffinic Oil (800 SUS/100 OF). API 83-12: Hydrotreated light naphthenic 50. 100. 200. 500 and lo00 p p for 0.5
(29-33068) distillate (CAS 64742-536). (34-32775) to 24 Hrj. (2640001)

54

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLa4b34 95 0732290 0550034 b 5 9 m

Five-Day Pilot Inhalation Study in Rats and Petroleum Hydrocarbon Toxicity Studies--7. hexane in the rat and mouse. (37-31 148)
Mice. Benzene. Final Report. (31-30448) [Tests of]Animal and Human Response to Study of Synergistic Effects of Certain Airborne
Four-week subchronic inhalation toxicity study Vapors of "70 Solvent." (26-60085) Systems in the Cynomolgus Monkey. (27-
in rats. Final repoii. API 81-07, Petroleum Hydrocarbon Toxicity Studies-1 i. 30704)
hydrodesulfurized kerosine (petroleum) Animal and Human Response to Vapors Teratology Studies in Rats. Raw Shale Dust.
(CAS 64742-81-0). API 81-09, hydrode- of Deodorized Kerosene. (26-60089) Final Report. (2660007)
sulfurized middle distillate (petroleum) Petroleum Hydrocarbon Toxicity Studies--13. Teratology Study in Rats. Retorted Shale Dust.
(CAS 64742-80-9). API 81-10, hydrode- Animal and Human Response to Vapors Final Report. (2660008)
sulfurized middle distillate (petroleum) of Toluene Concentnite. (2660091) The absence of hydrocarbon-induced nephro-
(CAS 64742-80-9). (33-32724) Petroleum Hydrocarbon Toxicity Studies-9. pathy in rats exposed subchmicaliy to
Further Investigation on the Effects of Sulfur Animal and Human Response to Vapors volatile hydrocarbon mixtures pertinent to
Dioxide on Human Subjects. (26-60022) of "80 Thinner." (2640087) gasoline (34-30857)
Interactive Effects of JP-5 Vapor Exposure and Petroleum Hydrocarbon Toxicity S t u d i e s 4 The Effect of a Rapid 4% Carboxyhemoglobin
Elevated Temperature on Renal Lesion Animal and Human Response to Vapors Saturation Increase on Maximal Treadmill
Induction [in Rats]. (30-31537) of Rubber Solvent. (26-60125) Exercise. (2660043)
Kidney Effects of Unleaded Gasoline. Compre- Petroleum Hydrocarbon Toxicity Studies-17. The Effect of Certain Light Hydrocarbons on
hensive and Critical Summary of Obser- Animal Response to n-Nonane Vapor. Kidney Function and Stnicture in Male
vations in Rats and Mice. (30-32845) (27-31352) Rats. (32-30408)
LC, acute inhalation toxicity evaluation of a Petroleum Hydrocarbon Toxicity Studies-15. The Effects of Chronic Exposure to Carbon
petroleum-derived hydrocarbon in rats. Animal Response to Vapors of "High Monoxide (100 P p m ) on the
API 81-08, sweetened naphtha (CAS Naphthenic Solvent." (27-31350) Cardiovascular System of Monkeys.
64741-87-3). Final report [by International Petroleum Hydrocarbon Toxicity Studies-14. [CRC-APRAC Project No. CAPM-4-68].
Research & Development Corp.]. (33- Animal and Human Response to Vapors (27-30966)
3 1827) of "High Aromatic Solvent." (27-31349) The Evaluation of the Three-Month Inhalation
LC, acute inhalation toxicity evaluation of a Petroleum Hydrocarbon Toxicity Studies-16. Toxicity of Two Motor Fuels (27-32610)
petroleum-derived hydrocarbon in rats. Animal Response to Vapors of The hemotoxicity of inhaled benzene to
API 81-03, light catalytically cracked "Naphthenic Aromatic Solvent." (27- Sprague-Dawley rats and AKR mice at
naphtha (CAS 64741-55-5). Final report. 31351) (30-0 ppm (33-31096)
(33-31 902) Petroleum Hydrocarbon Toxicity Studies-12. The Inhalation Toxicity of n-Hexane and
LC, Acute Inhalation Toxicity Evaluation of a Animal and Human Response to Vapors Methyl Ethyl Ketone. (30-32005)
Petroleum-Derived Hydrocarbon in Rats. of "40" Thinner. (26-60090) The Long-Tem Effects of Sulfur Dioxide on
Hydrodesulfurized Middle Distillate. API Petroleum Hydrocarbon Toxicity Studies--6. Ciliary Activity in the Trachea. (26-
Sample 81-09. (30-32856) Animal and Human Responses to Vapors 60071)
LC, Acute Inhalation Toxicity Evaluation of a of "60 Solvent." (2660084) The Myocardial Toxicity [to Dogs] of Selected
Petroleum-Derived Hydrocarbon in Rats. Petroleum H y d r o c a h Toxicity Studies-5. Aliphatic Hydrocarbons, [Including
Hydrodesulfurized Middle Distillate, API [Studies of]Animal and Human Response Propane (P), n-Butane, Isobutane, and a
Sample 81-10. (30-32857) to Vapors of Mixed Xylenes. (26-60083) Mixture of These Hydrocarbons (A45).
L C , Acute Inhalation Toxicity Evaluation of a Petroleum Hydrocarbon Toxicity Studies--3. and Mixtures of Isobutane with Methyl
Petroleum-Derived Hydrocarbon in Rats. Animal and Human Response to Vapors Chloroform, Trichloroethylene, Methyl
Hydrodesulfurized Kerosine, API Sample of Stoddard Solvent. (26-60124) Ethyl Ketone. and Methyl Isobutyl
8 1-07. (30-32855) Predicting ?he Carboxyhemoglobin Levels Ketone]. (30-32013)
Long-Tenn Inhalation Studies with Raw and Resulting from Carbon Monoxide [(CO)] The Pathogenesis of the Nephrotoxicity of
Processed [Oil] Shale Dusts. (30-31535) Exposures. (26-60106) Volatile Hydrocarbons in the Male Rat.
Motor Fuel Chronic Inhalation Study. Unleaded Range-finding inhalation toxicity study in mice (32-30409)
Gasoline. (32-32165) with C, aromatic hydrocarbons. Final Thirteen-Week Inhalation Toxicity Study of a
Non-Neoplastic Exposure-Related Renal report. (35-30937) O" to 145 O F Gasoline Distillate Fraction
Lesions in [Fischer (34-4 Male] Rats Renal Toxicity of [Vapors of] Gasoline and in Rats. Final Report. (32-32405)
Following Inhalation of [67-2056 Ppm] of Related Petroleum Naphthas in Male Rats. Thirteen-Week Inhalation Toxicity Study of
Unleaded Gasoline Vapors. (32-30407) (32-30414) C&, Hydrocarbon Blends in Rats. Final
Pathologic Findings in Laboratory Animals S e m i Immunoglobulin Levels of CD Rats and Report. (32-31472)
Exposed to Hydrocarbon Fuels of Military CD-1 Mice Exposed to Benzene Vapor. Thirteen-week subchronic inhalation toxicity
Interest. (32-30416) Final Report. (30-32848) study in rats with API 81-03: Light
Petroleum hydrocarbon Toxicity Studies-2. Short-Tenn Responses of Healthy and catalytic cracked naphtha (CAS 64741-55-
Animal and Human Response to Vapors Asthmatic Men to Ozone. Final Report, 5). (34-33173)
of Varnish Makers and Painters Naphtha. Phase 1: A Dose-Response Study of Toxicology of Mixed Distillate and High-
(26-60123) Healthy. Heavily Exercising Men Exposed Energy Synthetic Fuels. (32-30415)
Petroleum Hydrocarbon Toxicity Studies-8. to Ozone Concentrations near the Primary Xenobiotic-Induced Kidney Lesions: Hydro-
Animal and Human Response to Vapors [National Ambient Air Quality] Standard. carbons. [A Synopsis ofl the 90-Day and
of "140' Flash/Aliphatic Solvent." (26- (32-32755) 2-Year Gasoline Studies. (32-30412)
60086) Six Month Continuous Inhalation Exposures of [A Series of Nine] Inhalation Exposures of
Petroleum Hydrocarbon Toxicity Studies..lO. Rats to Hexane Mixtures. Phase I. (30- [Sprague-Dawley] Rats to Aerosolized
[On the Basis 04 Animal and Human 32858) Diesel Fuel (30-31531)
Response to Vapors of "50 Thinner." (26- Special pathology report. A thirteen-week [Bioldynaniics Inc. Project No. 78-72331 A 26-
60088) inhalation toxicity study of commercial Week Inhalation Toxicity Study of

55
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLm4634 95 D 0 7 3 2 2 9 0 0550015 5 9 5 D

Heptane in the Rat. (28-31209) irritation study in rabbits. Primary eye Catalytically Reformed Distillate (CAS
[Bio/dynaniics Inc. Project No. 78-72341 /A irritation study in rabbits. Dermal 64741-59-9). (32-32859)
(26- Week Inhalation Toxicity Study of sensitization study in guinea pigs. Final Acute Oral Toxicity Study in Rats. Acute
Toluene in the Rat. (28-31210) report. API 85-01, Stoddard solvent. (CAS Dermal Toxicity Study in Rabbits.
[In a Two-Year] Investigation of the Effects of 8052-41-3). (33-32723) Primary Dermal irritation Study in
Carbon Monoxide on 1401 Humans in the Acute oral toxicity study in rats. Acute dermal Rabbits. Primary Eye Irritation Study in
Driving Task. (2660049) toxicity study in rabbits. Primary dermal Rabbits. Dermal Sensitization Study in
irritation study in rabbits. Primary eye Guinea Pigs. API 83-06, Heavy
Intratracheal irritation study in rabbits. Dermal Catalytically Reformed Naphtha (CAS
sensitization study in guinea pigs. Final 64741-68-0). (32-32860)
A Mechanistic Evaluation of the Pulmonary report. API 83-20, light catalytic cracked Acute Toxicity Studies of Light Cataiyticaiiy
Toxicology of Nickel Subsulfide. (30- naphtha (petroleum). (CAS 64741-55-5). Cracked Naphtha. [API] Sample 81-03.
31992) (33-32722) (30-31988)
Acute oral toxicity study in rats. Acute dermal Acute Toxicity Studies of Vacuum Residuum,
Ocular toxicity study in rabbits. Primary dermal [API] Sample 81-14. (30-31989)
irritation study in rabbits. Primary eye Acute Toxicity Studies of Vacuum Residuum,
A Survey of Eye Irritation and Lachrymation in irritation study in rabbits. Dermal [API] Sample 81-13. (30-31987)
Relation to Air Pollution (2660052) sensitization study in guinea pigs. API Acute Toxicity Studies [by Hazleton Rallech
Acute oral toxicity study in rats. Acute dermal 83-15, hydrotreated heavy naphthenic Inc.] of Hydrodesulfurized Kerosine,
toxicity study in rabbits. Primary dermal distillate (CAS 64742-52-5). Final report [API] Sample 81-07. (30-31986)
irritation study in rabbits. Primary eye [by Hazleton Laboratories America Inc.]. Acute Toxicity Studies [by Hazleton Raltech
irritation study in rabbits. Dermal (33-32639) Inc. ofl Hydrodesulfurized Middle
sensitization study in guinea pigs. API Acute oral toxicity study in rats. Acute dermal Distillate, [API] Sample 81-10. (30-32348)
83-19, light alkylate naphtha (CAS toxicity study in rabbits. Primary dermal Acute Toxicity Studies [by Hazleton Raltech
64741-66-8). Final report. (33-30594) irritation study in rabbits. Primary eye Inc. ofj Hydrodesuifurized Middle
Acute oral toxicity study in rats. Acute dermal irritation study in rabbits. Dermal Distillate, [API] Sample 81-09. (30-32347)
toxicity study in rabbiis. Primary dermal sensitization study in guinea pigs. API Acute Toxicity Studies of Catalytically Cracked
irritation study in rabbits. Primary eye 84-02. heavy thermally cracked naphtha Clarified Oil, API Sample 81-15. (30-
irritation study in rabbits. Dermal (CAS 64741-83-9). Final report. (33- 3 1854)
sensitization study in guinea pigs. API 30596) Acute Toxicity Studies of Sweetened Naphtha,
83-18, heavy catalytically cracked naphtha Acute Oral Toxicity Study in Rats. Acute [API] Sample 81-08. (30-31990)
(CAS 64741-54-4). Final report. (33- Dermal Toxicity Study in Rabbits. Acute Toxicity Testing of Shale Oil and
30593) Primary Dermal Irritation Study in Process Materiais. Final Report. (26-
Acute oral toxicity study in rats. Acute dermal Rabbits. Primary Eye Irritation Study in 60027)
toxicity study in rabbits. Primary dermal Rabbits. Dermal Sensitization Study in The Acute Toxicology of Selected Petroleum
irritation study in rabbits. Primaiy eye Guinea Pigs. APl 83-11, Straight-Run Hydrocarbons. (30-3 1530)
irritation study in rabbits. Dermal Middle Distillate (CAS 64741-44-2). (32- Twenty-eight-day dermal toxicity study in the
sensitization study in guinea pigs. API 32857) rabbit- API 84-01, light paraffinic distillale
83-M. light catalytically cracked distillate Acute Oral Toxicity Study in Rats. Acute (CAS 64741-50-0). Final report [by
(CAS 64741-59-9). (33-30162) Dermal Toxicity Study in Rabbits. Tegens Laboratories inc.]. (33-31642)
Acute oral toxicity study in rats. Acute dermal Primary Dermal Irritation Study in [Hazleton Laboratories America Inc.'~] Acute
toxicity study in rabbits. Primary dermal Rabbits. Primary Eye Irritation Study in Oral Toxicity Study in Rats, A ~ t e
irritation study in rabbits. Primary eye Rabbits. Dermal Sensitization Study in Dermal Toxicity Study in Rabbits, Pri-
irritation study in rabbits. Dermal Guinea Pigs. API 83-09. Straight Run mary Dermal Irritation Study in Rabbits,
sensitization study in guinea pigs. API Kerosine (CAS 8008-20-6). (32-32858) and Primary Eye Irritation Study in
84-01, light paraffinic distillate (CAS Acute Oral Toxicity Study in Rats, Acute Rabbits of API 83-05 Full Range Cata-
64741-50-0). Final report. (33-30595) Dermal Toxicity Study in Rabbits, lytically Reformed Naphtha. (32-31474)
Acute oral toxicity study in rats. Acute dermal Primary Dermal Irritation Study in [Project No. 14431 /Acute Toxicity Tests of
toxicity study in rabbits. Primary dermal Rabbits, [and] Primary Eye Irritation API #78-2 No. 2 Home Heating Oil (30%
initation study in rabbits. Primary eye Study in Rabbits of API 81-04, Light Cat) (27-32771)
irritation study in rabbits. Dermal Catalytically Cracked Naphtha. (32-31708) [Project No. 14431 /Acute Toxicity Tests of
sensitization study in guinea pigs. API Acute Oral Toxicity Study in Rats, Acute API #78-3 No. 2 Home Heating Oil (lû%
83-12, hydrotreated light naphthenic Dermal Toxicity Study in Rabbits, Cat) (27-32773)
distillate (CAS 64742-53-6). Final report. Primary Dermal Irritation Study in [Project No. 14431 /Acute Toxicity Tests of
(33-30592) Rabbits, and Primary Eye Irritation Study API Jet Fuel A (27-32815)
Acute oral toxicity study in rats. Acute dermal in Rabbits of API 83-04 Light [Project No. 14431 /Acute Toxicity Tests API...
toxicity study in rabbits. Primary dermal Catalytically Reformed Naphtha. (32- 79-7 Used Composite Motor Oil. (27-
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

irritation study in rabbits. Primary eye 31473) 32772)


irritation study in rabbits. Dermal Acute Oral Toxicity Study in Rats. Acute [Project No. 14431 /Acute Toxicity Tests...API
sensitization study in guinea pigs. API Dermal Toxicity Study in Rabbits. 78-8 No. 6 Heavy Fuel Oil (23.1
83-16. light paraffinic distillate solvent Primary Dermal Irritation Study in 'AP1/0.2% S). (27-32816)
extract (CAS 6474245-8). (33-31226) Rabbits. Primary Eye Irritation Study in [Project No. 14431 /Acute Toxicity Tests [ofl
Acute oral toxicity study in rats. Acute dermal Rabbits. Dermal Sensitization Study in API #78-1, New Composite Motor Oil.
toxicity study in rabbits. Primary dermal Guinea Pigs. API 83-08. Light (27-32131)

56

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L r 4 b 3 4 9 5 O732290 0 5 5 0 0 3 b 4 2 1

[Project No. 14431 Acute Toxicity Tests [of] toxicity study in rabbits. Primary dermal Pigs. API 83-1 i , Straight-Run Middle
API #PS-6, Unleaded Motor Gasoline (27- initation study in rabbits. Primary eye Distillate (CAS 64741-44-2). (32-32857)
32130) irritation study in rabbits. Dermal Acute Oral Toxicity Study in Rats. Acute
[Project No. 14431 Acute Toxicity Tests [on] sensitization study in guinea pigs. API Dermal Toxicity Study in Rabbits.
API #78-4. No. 2 Home Heating Oil (50% 83-07. light catalytically cracked distillate Primary Dermal Irritation Study in
Cat) (27-32068) (CAS 64741-59-9). (33-30162) Rabbits. Primary Eye Irritation Study in
[Project No. 14431 Acute Toxicity Tests of API Acute oral toxicity study in rats. Acute dermal Rabbits. Dermal Sensitization Study in
78-7 No. 6 Heavy Fuel Oil (17.1 toxicity study in rabbits. Primary dermal Guinea Pigs. API 83-09, Straight Run
OAPI/0.8% S) (27-32774) irritation study' in rabbits. Primary eye Kerosine (CAS 8008-20-6). (32-32858)
[Project No. 14431 Acute Toxicity Tests...API irritation study in rabbits. Dermal Acute Oral Toxicity Study in Rats, Amte
79-6 Diesel Fuel (Marketplace Sample). sensitization study in guinea pigs. API Dennal Toxicity Study in Rabbits,
(27-32817) 84-01, light paraffinic distillate (CAS Primary Dermal Irritation Study in
[Project No. 14431 Acute Toxicity Tests of API 64741 -50-0). Final report. (33-30595) Rabbits. [and] Primary Eye Irritation
79-2 No. 6 Heavy Fuel Oil (5.2 Acute oral toxicity study in rats. Acute dermal Study in Rabbits of API 81-04, Light
"AP1/1.2% S) (27-32813) toxicity study in rabbits. Primary dermal Catalytically Ctacked Naphtha. (32-31708)
[Project No. 14431 Acute Toxicity Tests...API irritation study in rabbits. Primary eye Acute Oral Toxicity Study in Rats, Acute
78-6 No. 6 Heavy Fuel Oil (11.7 initation study in rabbits. Dermal sensiti- Dermal Toxicity Study in Rabbits, Pri-
"APIj2.7% S). (27-32814) zation study in guinea pigs. API 83-12, mary Dennal Irritation Study in Rabbits,
[Project No. 15971 Acute Toxicity Tests of API hydrotreated light naphthenic distillate and Primary Eye Irritation Study in
79-1, Naphthenic Oil (90 SUSR10 OF). (CAS 64742-53-6). Final report. (33- Rabbits of API 83-04 Light Catalytically
(29-33065) 30592) Reformed Naphtha. (32-31473)
[Project No. 15981 Acute Toxicity Tests, API Acute oral toxicity study in rats. Acute dermal Acute Oral Toxicity Study in Rats. Acute
79-3. Paraffinic Oil (350 SUS/lOO OF). toxicity study in rabbits. Primary dermal Dermal Toxicity Study in Rabbits.
(29-33067) irritation study in rabbits. Primary eye Primary Dermal Irritation Study in
[Project No. 15991 Acute Toxicity Tests of API initation study in rabbits. Dermal Rabbits. Primary Eye Irritation Study in
79-4, Paraffinic Oil (550 SUS/iOO OF). sensitization study in guinea pigs. API Rabbits. Dermal Sensitization Study in
(29-33066) 83-16, light paraffinic distillate solvent Guinea Pigs. API 83-08, Light
[Project No. 16001 Acute Toxicity Tests. API extract (CAS 64742-05-8). (33-31226) Catalytically Reformed Distillate (CAS
79-5, Paraffinic Oil (800 SUS/lOO OF). Acute oral toxicity study in rats. Acute dermal 64741 -59-9). (32-32859)
(29-33068) toxicity study in rabbits. Primary dermal Acute Oral Toxicity Study in Rats. Amte
[Project No. 1M)1] Acute Toxicity Tests of API irritation study in rabbits. Primary eye Dermal Toxicity Study in Rabbits.
78-9, Paraffinic Oil (70 SUS/lOO OF). (29- irritation study in rabbits. Dermal Primary Dermal Irritation Study in
33104) sensitization study in guinea pigs. Final Rabbits. Primary Eye Irritation Study in
[Project No. 16021 Acute Toxicity Tests of API report. API 85-01, Stoddard solvent. (CAS Rabbits. Dermal Sensitization Study in
78-10. Paraffinic Oil (i50 SUS/lOO OF). 8052-4 1-3). (33-32723) Guinea Pigs. API 83-06, Heavy
(29-33105) Acute oral toxicity study in rats. Acute dermal Catalytically Reformed Naphtha (CAS
[Project No. 16161 Acute Toxicity Tests of API toxicity study in rabbits. Primary dermal 64741-68-0). (32-32860)
78-5, Naphthenic Oil (150 SUS/iOO OF). irritation study in rabbits. Primary eye Acute Toxicity Studies of Vacuum Residuum,
(29-33106) initation study in rabbiis. Dermal sensiti- [API] Sample 81-13. (30-31987)
zation study in guinea pigs. Final report. Acute Toxicity Studies of Vacuum Residuum,
Oral API 83-20. light catalytic cracked naphtha [API] Sample 81-14. (30-31989)
(petroleum) (CAS 64741-55-5). (33- Acute Toxicity Studies [by Hadeton Raitech
A 90-day feeding study in the rat with six 32722) Inc.] of Hydrodesuìfurized Kerosine,
different white mineral oils (N15 @I). N70 Acute oral toxicity study in rats. Acute dermal [API] Sample 81-07. (30-31986)
(H), N70 (A), P15 (H), N10 (A). and toxicity study in rabbits. Primary dermal Acute Toxicity Studies of Catalytically Cracked
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

P100 (H, three different mineral waxes (a irritation study in rabbiis. Primary eye Clarified Oil, API Sample 81-15. (30-
low-melting-point wax. a high-melting- irritation study in rabbits. Dermal sensiti- 3 1854)
point wax, and a high-sulphur wax) and zation study in guinea pigs. API 83-15, Acute Toxicity Studies [by Hazieton Raltech
COConUt Oil. July 1992. (39-32387) hydrotreated heavy naphthenic distillate Inc. of] Hydrodesulfurized Middle
Acute oral toxicity study in rats. Acute dermal (CAS 64742-52-5). Final repon [by Distillate. [API] Sample 81-10. (30-32348)
toxicity study in rabbits. Primary dermal Hazieton Laboratories America Inc.]. (33- Acute Toxicity Studies [by Hazleton Raltech
irritation study in rabbits. Primary eye 32639) Inc. of] Hydrodesuìfurized Middle
irritation study in rabbits. Demial Acute oral toxicity siudy in rats. Acute dermal Distillate, [API] Sample8149. (30-32347)
sensitization study in guinea pigs. API toxicity study in rabbits. Primary dermal Acute Toxicity Studies of Light Catalytically
83-19, light alkylate naphtha (CAS irritation study in rabbits. Primary eye Cracked Naphtha, [API] Sample 81-03.
64741-66-8). Final report. (33-30594) irritaiion study in rabbits. Dermal sensiti- (30-31988)
Acute oral toxicity study in rats. Acute demial zation study in guinea pigs. API 84-02, Acute Toxicity Studies of Sweetened Naphtha,
toxicity study in rabbits. Primary dermal heavy thermally cracked naphtha (CAS [API] Sample 81-08. (30-31990)
irritation study in rabbits. Primary eye 64741-83-9). Final repon. (33-30596) Acute Toxicity Testing of Shale Oil and
irritation study in rabbits. Dermal sensiti- Acuie Oral Toxicity Study in Rats. Acute Process Materials. Fmal Report. (26-
zation study in guinea pigs. API 83-18, Dermal Toxicity Study in Rabbits. Pri- 60027)
heavy catalytically cracked naphtha (CAS mary Dermal Irritation Study in Rabbits. Final Report. A four-week orai nephrotoxicity
64741-54-4). Final report. (33-30593) Primary Eye Irritation Study in Rabbits. screening study in male F344 rats (33-
Acute oral toxicity study in rats. Acute dermal Dermal Sensitization Study in Guinea 31097)

57

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLb4634 95 0732290 0550037 368

Fwr-Week Oral Nephrotoxicity Screening 79-1. Naphthenic Oil (90 SUS/2lO OF). Effects of Oil on Aquatic Organisms ...A
Study in Maie F344 Rats [by ßomston (29-33065) Review of Selected Literature (29-30299)
Laboratories lnc.]. Final Report. (32- [Project No. 15981 Acute Toxicity Tesis, API Facts and Opinions on the Role of Sulfur
30966) 79-3. Paraffinic Oil (350 SUS/lOO OF). Dioxide in Causing Injury [to Human
Hydrocarbon nephropathy in male rats: Identifi- (29-33067) Health]. (2660095)
cation of the nephrotoxic components of [Project No. 15991 Acute Toxicity Tests of APl Fluorosis of Livestock. (26-60107)
unleaded gasoline (33-31098) 79-4. Paraffinic Oil (550 SUS/100 OF). Gaseous and Particulate Sulfur Compounds in
Hydrocarbcm nephropathy in male rats. Tempo- (29-33066) Urban Atmospheres. (26-60070)
ral and morphologic characterization of [Project No. 16001 Acute Toxicity Tests, API Hydrocarbon Toxicity: Acute, Subchronic and
the renal lesions. (33-31223) 79-5, Paraffinic Oil (800 SUS/100 OF). Chronic Effects in Relation to Unleaded
Serial Sacrifice Study [by Borriston (29-33068) Gasoline Exposure of Rodents, with
Laboratories Inc.] with [API PS-61 [Project No. 16011 Acute Toxicity Tests of APl Comments on the Significance to Human
Unleaded Gasoline in Rats. Final Report. 78-9, Paraffinic Oil (70 SUS/lOO OF). (29- Health. (32-30192)
(32-31048) 33 104) Lithium. (2660067)
T h e Acute Toxicology of Selected Petroleum [Project No. 16021 Acute Toxicity Tests of API Manganese. (26-601 14)
Hydrocarbons. (30-31530) 78-10, Paraffinic Oil (150 SUS/lOû OF). Methanol health effects. Epidemiology literature
The Chronic Toxicity of Lead. (26-60096) (29-33 105) review and search for study population--1.
Twenty-eight-day dermal toxicity study in the [Project No. 16161 Acute Toxicity Tests of API Critical review of the literature. 2. Search
rabbit. API 84-01. light paraffinic distillate 78-5. Naphthenic Oil (150 SUS/lOO OF). for study population. (39-31095)
(CAS 64741-50-0). Final report [by (29-33106) Microparticulate Sulfates: Effects on Human
Tegeris Laboratories Inc.]. (33-31642) Health. (26-601 16)
[Hazleton Laboratories America Inc.'s] Acute Review Nickel. (26-60112)
Oral Toxicity Study in Rats, Acute Oxidants: Air Quality Criteria Based on Health
Dermal Toxicity Study in Rabbits. Pri- A Brief Review of [Published Data on] the Effects. (26-60060)
mary Dermal Imtation Study in Rabbits, Toxicity and Carcinogenicity of Select Particulates: Air Quality Criteria Based on
and Primary Eye Imtation Study in Chlorinated Hydrocarbons. (32-3041 7) Health Effects. (26-60058)
Rabbits of API 83-05 Full Range Cata- A Review of the Toxicology of Lead (26- Phosphonis. (26-60066)
lytically Reformed Naphtha. (32-31474) 60061) Polycyclic Aromatic Hydrocahns [(PAHs)] :
[Project No. 14431 Acute Toxicity Tests of API A Review of the Human Kidney Effects of A Review (28-30174)
78-7 No. 6 Heavy Fuel Oil (17.1 Hydrocarbon Exposure (32-30410) Response of Specific Airways Resistance to
DAPI/0.8% S) (27-32774) A Unified Approach to the Use of Human SO, in the Exercising Asthmatic: Dose
[Project No. 14431 Acute Toxicity Tests...API Clinical and Animal Toxicologic Data; Considerations. (32-32461)
79-7 Used Composite Motor Oil. (27- Application to the Establishment of Review of inhalation Toxicology of Sulfuric

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
32772) Ambient Air Quality Criteria. Volume IA: Acid and Sulfates. (26-60024)
[Project No. 14431 Acute Toxicity Tests [on] Effect of Ozone on Airway Resistance Study of the relationship between folate status
API #78-4, No. 2 Home Heating Oil (50% (Raw) and Forced Expiratory Volume and methanol toxicity. (41-30101)
Cat) (27-32Oó8) (FEV,,) in Humans. Final Report. (32- Summation/Comments on Structure-Activity
[Project No. 14431 Acute Toxicity Tests [of] 32503) Relationships. (32-30422)
APl t78-1. New Composite Motor Oil. A Unified Approach to the Use of Human The Molecular Site of Benzene Toxicity. (26-
(27-32131) Clinical Data: A Case Study of Nitrogen 60078)
[Project No. 14431 Acute Toxicity Tests [ofl Dioxide and Sulfur Dioxide. (32-32502) The Renal Effects of Petroleum Hydrocarbons,
API #PSá, Unleaded Motor Gasoline (27- Air Quality Standards for Carbon Monoxide. Symposium (Boston 7/18-20/83). (32-
32130) (26-60062) O 1362)
[Project No. 14431 Acute Toxicity Tests of API Air Quality Standards for Lead. (26-60064) Tin. (26-60069)
#78-3 No. 2 Home Heating Oil (10% Cat) Ambient Air Quality Standards for Vanadium: Environmental and Community
(27-32773) Particulates ...Review and Evaluation. (26- Health Impact. (32-30600)
[Project No. 14431 Acute Toxicity Tests of API 60057) Vanadium. (26-6011i)
#78-2 No. 2 Home Heating Oil (30-% API Mineral Oil Review. (39-31651) Xenobiotic-Induced Kidney Lesions: Hydro-
Cat) (27-32771) Arsenic. (26-60065) carbons. [A Synopsis ofl the 90-Day and
[Project No. 14431 Acute Toxicity Tests of API Barium. (26-60110) 2-Year Gasoline Studies. (32-30412)
Jet Fuel A (27-32815) Benzene Toxicity. A Critical Evaluation (26- [A Review on] Hematotoxicity in Humans (26-
[Project No. 1443J Acute Toxicity Tests...AP1 60074) 60073)
79-6 Diesel Fuel (Marketplace Sanipie). Cadmium. Zinc, and Mercury. (26-60115) [A Review on] Experimental Benzene
(27-32817) Cadmium: Environmental and Community Intoxication (26-60077)
[Project No. 14431 Acute Toxicity Tests of API Health Impact. (32-30599) [This Compilation Based on the 1st API -
79-2 No. 6 Heavy Fuel Oil (5.2 Chromium. (26-601 13) Society of Toxicology "Toxicology of
"API/1.2% S) (27-32813) Clinical toxicology of the acute ingestion of Petroleum Hydrocarbons" Symposium
[Project No. 14431 Acute Toxicity Tests...API methanol/hydrocarbon blends. A (Washington, D.C. 5/11-13/82).] (30-
78-8 No. 6 Heavy Fuel Oil (23.1 state-of-the-art review. (39-3 1093) 31529)
"API/0.2% S ) . (27-32816) Copper. (26-60068)
[Project No. 14431 Acute Toxicity Tests...API Cytologic and Cytogenetic Effects of Benzene Siròcuianeous
78-6 No. 6 Heavy Fuel Oil (11.7 [on Human Health]. (26-60121)
"API/2.7% S). (27-32814) Dioxins and furans.../\ primer: What they are Effects of Subchronic Fourteen Day Exposure
[Project No. 15971 Acute Toxicity Tests of API and how to measure them. (37-31299) to ßenzopyrene in B6C3F1 Male and

58

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLW4634 95 0732290 0 5 5 0 0 3 8 2 T 4 =

Female Mice on Specific immunological Animal and Human Response to Vapors


Parameters. Final Repon. (30-32850) of Varnish Makers and Painters Naphtha.
Effects of Subchronic Fourteen-Day Exposure Toxicity Sruày (2660123)
to Benzopyrene in B6C3F1 Female Mice
on Host Resistance. Final Report [by the Four-Week Oral Nephrotoxicity Screening VACUUM RESIDUUM
Medical College of Virginia]. (32-31512) Study in Male F344 Rats [by Bomston
Immunotoxicology of benzopyrenes in Fisher Laboratories Inc.]. Final Report. (32- Carcinogenicity Study
( 3 4 4 rats. Final report. (33-31750) 30966)
Lifetime Dermal Carcinogenesis/Chronic
1,1,1-TRICHLOROETHANE (REVIEW) 2JJ-TRIMETHY LOCTANE Toxicity Screening Bioassay of Refinery

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Streams in C3HkieJ Mice. Three-Month
Neurotoxicity study Toxiciry Stidy Toxicity Evaluation Report. [Vol. 1-21.
(32-32653)
Neurotoxicity of organic solvents with special Final Repon. A four-week oral nephrotoxicity Lifetime dermal carcinogenesis bioassay of refi-
reference to the neurobehavioral effects: A screening study in male F344 rats (33- nery streams in C3H/HeJ mice (AP-135R).
[world] literature review (39-30623) 31097) (36-31364)
Lifetime dermal carcinogenesis/chronic toxicity
TRICHLOROEïHYLENE 2 , 2 , 4 T R I M n H Y LPENTANE screening bioassay of refmery streams in
C3H/HeJ mice. Twelve-month toxicity
Toxicity Stiuiy Mutagenicity Study evaluation report. Final report. [Vol.1-31.
(33-31451)
The Myocardial Toxicity [to Dogs] of Selected The W 178Y TK+/- mouse lymphoma mutagen- Shoa-term dermal tumorigenesis study of selec-
Aliphatic Hydrocarbons, [Including esis assay with 2.2,4-tnmethylpentane. ted petroleum hydrocarbon [processing
Propane (P), n-Butane. Isobutane. and a Final report. (34-33107) fractions] in male CD-1 mice. Initiation
Mixture of 'Ihese Hydrocarbons (A-46), and promotion phases. (36-32643)
and Mixtures of Isobutane with Methyl Toxicity Stiuiy
Chloroform, Trichloroethylene. Methyl Miiragenicity Sruày
Ethyl Ketone. and Methyl Isobutyl Four-Week Oral Nephrotoxicity Screening Stu-
Ketone]. (30-32013) dy in Male F344 Rats [by Bomston Labo- Mutagenicity Evaluation Studies in the Rat
ratories Inc.]. Final Report. (32-30966) Bone Marrow Cyiogenetic Assay [and] in
the Mouse Lymphoma Forward Mutation
TRICHLOROETHYLENE (REVIEW) 2,3,4TRIMEïHY LPENTANE Assay. Vacuum Residu um...API Sample
81-13. (31-30614)
Neurotoxicity Study Meta bolismlPharmacokineiics Mutagenicity Evaluation Studies in the Rat
Bone Marrow Cytogenetic Assay and in
Neurophysiological and Psychological Disorders Studies on the absorption of inhaled hydro- the Mouse Lymphoma Forward Mutation
and Occupational Exposure to Organic carbon vapors. Final report. (34-33036) Assay. Vacuum Residu um... API Sample
Solvents. (31-32980) 81-14. (31-30615)
Neurotoxicity of organic solvents with special TUNGSTEN (REVIEW)
reference to the neurobehavioral effects: A Toxicity Sriidy
[world] literature review (39-30623) Toxicity Siiuiy
A 28-Day Demal Toxicity Study of API
Chromium. (26-601 13) [Vacuum Residuum] Sample 81-13 in the
lJ,4-TRIMETHYLBENZEN E Rabbit (30-32852)
VM&P NAPHTHA A 28-Day Dermal Toxicity Study of API
MerabolismlPharniacokinetics [Vacuum Residuum] Sample 81-14 in the
Developmental Elfecis Rabbit. (30-32853)
Studies on the absorption of inhaled hydro- Acute Toxicity Studies of Vacuum Residuum,
carbon vapors. Final report. (34-33036) Inhalatiofleratology Study in Rats. VM and P [API] Sample 81-13. (30-31987)
Naphtha. Final Report. (27-30484) Acute Toxicity Studies of Vacuum Residuum,
Toxicity S i i d y (API] Sample 81-14. (30-31989)
Mittagenicity Sriidy Demal Sensitization Study in Guinea Pigs.
Four-Week Oral Nephrotoxicity Screening Closed Patch Technique. Vacuum
Study in Male F344 Rats (by Bomston Estimation of the Mutagenicity of Hydrocarbon Residuum, API Sample 81-13. (31-31415)
Laboratories Inc.]. Final Report. (32- Fractions Utilizing the Bacterial Assay Dermal Sensitization Study in Guinea Pigs.
30966) Procedure with Mammalian Tissue Closed Patch Technique. Vacuum
Metabolic Activation. API Project PS-4 Residuum, API Sample 81-14. (31-31416)
2JJ-TRIMETHY LDECANE #6. (26-60103) Lifetime dermal carcinogenesis/ chronic toxicity
Mutagenicity Study of Thirteen Petroleum screening bioassay of refinery streams in
Toxicity Stiuiy Fractions. (26-60098) C3H/HJ mice. Twelve-month toxicity
evaluation report. Final report. [Vol. 1-31.
Final Report. A four-week oral nephrotoxicity Toxicity Stidy (33-3 1451)
screening study in male E344 rats (33- Short-term dermal tumorigenesis study of selec-
31097) Petroleum hydrocarbon Toxicity Studies--2. ted petroleum hydrocarbon [processing

59

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L X 4 6 3 4 95 = 0732290 0550039 130 W

fractions] in male CD-1 niice. Initiation [Studies of] Animal and Human Response p-XYLENE
and promotion phases. (36-32643) IO Vapors of Mixed Xylenes (26-60083)
Human Exposure Assessmenr
VANADIUM
XYLENES (REVIEW) Exposure data on C7 and C, aromatics during
Fate and Effects handling and production of motor
gasolines. (33-31598)
Bicaccumulation of polycyclic aromatic hydro- Aquatic Toxicity
carbons and metals in estuarine organisms. ZINC (REVIEW)
(40-3074 1) Benzene. Xylene, and Toluene in Aquatic
Systems: A Review (27-32296) Toxirip Stuày
VANADIUM (REVIEW)
Hirman Exposure Assessment Cadmium, Zinc, and Mercury. (2640115)
Toxicity Study
Use of biological monitoring and biomarkers.
Vanadium. (26-601 11) State-of-the-art review. (40-32427)
Vanadium: Environmental and Community
Health Impact. (32-30600) Neirroroxicity Study

VIRGIN GAS OIL (REVIEW) Neurophysiological and Psychological Disorders


and Occupational Exposure to Organic

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
Carcinogenicity Study Solvents. (31-32980)
Neurotoxicity of organic solvents with special
Investigation of the Potential Hazards of Cancer reference to the neurobehavioral effects: A
of the Skin Associated with the Refining [world] literature review (39-30623)
of Petroleum. Final Report. (26-60028)

WHITE SPIRIT (REVIEW) m-XYLENE

Neurotoxicity Study Human Exposure Assessment

Neurophysiological and Psychological Disorders Exposure data on C, and C, aromatics during


and Occupational Exposure to Organic handling and production of motor
Solvents. (31 -32980) gasolines. (33-31598)

XYLENES Meia bolismlPLarniocokineiics

Developmental Effects Absorption of petroleum products across the


skin of the monkey and miniature pig.
Parental and Fetal Reproduction halation Tox- Annual report (Mar. 15. 1979-Mar. 14,
icity Study. in Rats, with Mixed Xylenes. 1980). (33-31034)
Final Report. [Vol. I & II]. (31-31481)
Teratology Study in Rats. Xylene. Final Report. Toxicity Stuày
(26600 13)
Four-Week Oral Nephrotoxicity Screening
Mutagenicity Study Study in Male F344 Rats [by Bomston
Laboratories Inc.]. Final Report. (32-
Estimation of the Mutagenicity of Hydrocarbon 30966)
Fractions Uiilizing the Bacterial Assay
Procedure with Mammalian Tissue
Metabolic Activation. API Project PS-4 O-XYLENE
#6. (26-60103)
Mutagenicity Evaluation of Xylene. (26-60018) Hrimun Exposure Assessnienr
Mutagenicity Study of Thiiieen Petroleum
Fractions. (26-60098) Exposure data on C, and C, aromatics during
handling and production of motor
Reproductive Effects gasolines. (33-31598)

Teratology Study in Rats. Xylene. Final Report. Metabo1isnilPliarniacokinet;cs


(2660013)
Absorption of petroleum products across the
Toxicity Study skin of the monkey and miniature pig.
Annual report (Mar. 15. 1979-Mar. 14,
Petroleum Hydrocarbon Toxicity Siudies--5. 1980). (33-31034)

60

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L X 4 6 3 4 95 0732290 0550020 7-52

ABSTRACTS
24-30057 American Petroleum Institute)
Carboxyhemoglobin Trend in Chicago Blood Donors, 1970-1974. An S. S. Rossi; J. W. Anderson; G. S. Ward flex. A%M Univ.),
18% reduction in the carboxyhemoglobin (HbCO) saturation in nonsmok- Environmental Pollution 10(1):9-18 (Jan. 1976).
ing Chicago blood donors occurred between 1970 and 1974. indicating Source: Not available from API
that donors in 1974 were being exposed to a lower average carbon
monoxide (CO) concentration than was experienced by 1970 donors. In 26-60003
1970, 74% of the nonsmokers in Chicago were being exposed to CO in Mutagenic Evaluation of 60 Solvent (CHF-33-118). 60 Solvent
excess of the amount pemiitted by the Federal air quality standards, but (CHF-33-148) showed no mutagenic activity in a series of in vitro and
in 1974, only 41% of the nonsmokers were being overexposed. The in vivo tests. 'iñe in vitro studies involved Ames assay with bacteria
observed reduction in HbCO correlates well with both the ambient CO Salmonella and yeasts Sacchrrromyces, with and without mouse-liver
levels recorded at the air monitoring stations and the reduction in CO tissue activatiai, and mouse lymphoma assay. In the in vivo studies the
emission from automobiles. if the current trend continues, Chicago bone m a m w cell chromosomes of rats were examined for induced
should reach canpliance with air quality standards for CO by 1985. The aberrations. Tables. (supported by the American Petroleum Institute)
measurement of HbCO in a representative urban population is an 8 API Meaïcal Research Publication (10/31n5) (150 p.).
accurate index of actual CO exposure and supplements the air pollution Source: APl Library
data provided by air monitoring stations. Map, graphs. tables, and 19
references. See also Abstract No. 21-30100. 26-60001
R. D.Stewart: C. H. Hake; J. H. Kalbfleisch; T. A. Stewart: A. Wu. Mutagenicity Evaluation of [Shale Oil] R-01. Draft Report. Shale Oil
(Med. Coll. Wis.), Archives of Environmental Heolili 3 1(6):280-86 R-01 showed mutagenic activity in Ames assay on Salmonella bacteria
(Nov.-Dec. 1976). activated with rat liver tissue, weak activity in the absence of activation
Source: Not Available from APl and also in mouse lymphoma in vitro assays. No significant effect was
observed in in-vivo studies of frequency of chromosane aberrations in
26.31781 rat bone marrow cells. Tables. (supported by the American Petroleum
Phenolics in Aquatic Ecosystems: A Selected Review of Recent Institute)
[(1950-79)1 Literature covers analytical chemistry; synthetic sources of API Medical Research Publicarion (Tlec. 1975) (150 p.).
phenolics, e.g., natural gas plants, oil refineries, and diemical plants: Source: API Libmy
natural phenolics, e.g., from leaf litter: chlorination of phenolics: toxicity
of phenolics to bacteria. fungi. achlorophyllous protozoa, algae. and 26-60005
plants; acute and chronic effects on animals; modifiers of phenolic Mutagenicity Evaluation of [Shale Oil] R-03. Draft Report. Shale oil
toxicity. including contaminants, structural and chemical properties, and R-03 showed mutagenic activity in Ames assays on bacteria Salmonella
environmental and biological factors: phenolics as nonspecific metabolic with activation by rat liver tissue. It was not mutagenic tests with the
inhibitors: organismal effects, including development and growth, bacteria without activation. nor did it show activity in in-vitro mouse
physiology and history, oxygen consumption. feeding, behavior, and lymphoma assays. In-vivo studies showed no activity with respect to
other effects: populations and community effects: taste and odor chromosome aberrations in rat bone marrow cells. Tables. (suppoiied by
problems: and environmental fate and effects, including transport, the American Petroleum institute)
microbial and photochemical degradation. and uptake and depuraiion. API Medical Research Publication (Jan. 1978) (150 p.).
Tables and about 375 references. (supported by API) See also Abstract Source: APl Library
NO. 23-30918, 25-32531. and 26-31539.
B A. L Buikema: J. Cairns (Va. Polytech. Inst. & State Univ.); M. J. 26-60001
McGiniiiss (Metcalf & Eddy Inc.). hforiiw Envirorimenrol Reseorch Mutagenicity Evaluation of Retorted Shale. Final Report. Retorted
2(2):87-181 (Apr. 1979). shale showed no mutagenic activity in a series of in-vitro and in-vivo
Source: Not available from A1'1 tests. The in-vitro studies involved Ames assay with bacterial Salmonella
and yeasts Saccharomyces, with and without rat-liver tissue activation,
26-60001 and mouse lymphoma assay. In the in-vivo studies the bone marrow cell
Expcrimciital Human Exposure to Carbon Monoxide [at Concentra- chromosomes of rats were examined for induced abenations. Tables.
tions of c 1,25,50,100,200,500 and 1000 ppm for 0.5 to 2 1 Hr] led (supported by the Amencan Petroleum Institute)
to no untoward effects in sedentary males exposed to 100 ppm or less for API Medical Research Publication (July 1978) (60 p.).
8 hr. Exposures producing carboxyiien:oglobin saturations > 6 2 0 % Source: APl Library
resulted in delayed headaches. changes in the visual evoked response,
and impairment of nianual coordination. Diagram, graph, and tables. 26-60007
R. D. Stewart: J. E. Peterson: R. T. Bachand: E. D. Baretta; A. Teratology Studies in Rats. Raw Shale Dust. Final Report. Exposing
-
Hemnann: M. J. Hosko (Marquette Sch. Med. Gen. Mot. Corp.), pregnant rats to air containing 17.7 or 101.5 mdcu m of raw shale dust
Archives of Environmental Health 21(2):154-64 (Aug. 1970). caused no adverse effects on either the mother or the embryos. Exposure
Source: Not available from API was during days 6 through 15 of gestation for 6 hrlday. The dust was
more than 90% below 10 microns particle size. The condition of the
26-60002 pregnant rats was evaluated on h e basis of body weight, food consump-
The Toxicity of Water-Soluble Fractions of Four Test Oils for the tion, and general behavior. Fetus effects were determined by removal of
Polychaetous Annelids Neanthes arenaceodentata and Capitella the uterus on the 20ih day of gestation and examination for number and
capitala were studied in the laboratory. The two refined oils. No. 2 fuel placement of implantations and resorptions. number of live and dead
oil and bunker C residual oil. proved niost toxic to both species. South fetuses, soft tissue changes, and skeletal abnormalities. Tables. (Support-
Louisiana crude oil was less toxic than either of the refined oils, yet ed by the American Petroleum Institute)
more toxic than Kuwait crude oil. The higher concentrations of toxic B API Medical Research Publication (Oct. 1978) (25 p.).
diaromatic compounds (naphthalenes) found in refined oils probably Source: API Library
accounted for major differences between the toxicity of refined vs. crude
oils. Capitella capiiata was slightly more sensitive to three of the four 26-60008
oils than was Neonflies arenoceodeniaia. Both species appear to be quite Teratology Study in Rats. Retorted Shale Dust. Final Report.
similar to fish and crustaceans in thcir sensitivity to these four oils. Exposure of pregnant female rats to air containing 62.2 or 145.6 mgícu
Tables, graphs, and 14 references. (supported by Exxon Co. U.S.A. and ni of retorted shale dust had no effects on the embryos, but caused

61
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLa4634 95 0732290 0550023 899

increased incidence of pulmonary changes in the mothers. 'lñe pregnant 26-60015


rats were exposed to the retorted shale on days 6 through 15 of gestation Teratology Study in R a t s Rubber Solvent. Final Report. Exposing
for 6 hr/day. Particle size of the dust was more than 90 per cent below pregnant female rats to atmospheres containing 800 and 1600 ppm of
4 10 microns. Effects on the fetuses were determined by removing the rubber solvent for 6 hr/day on days 6-15 of gestation produced no ill
UWNS on day 20 of gestation and determining the number and placement effects on the dams and no terata, fetal sex ratio variation, embryo
of implantations and resorptions, the number of live and dead fetuses, toxicity, or inhibition of fetal growth. Tables. (Supported by the
3 soft tissue changes. and skeletal abnomalities. Although the exposed rats American Petroleum Institute)

i showed lung changes on necropsy, exposure to the dust had no effect on


body weight or food consumption. Tables. (Supported by the American
Petroleum Institute)
8 API Medical Research Publication (Oct. 1978) (7 p.).
8 APi Medical Research Publication (June 1978) (17 p.).
Source: API Library

26-60016
i Source: API Library Mutagenic Evaluation of Filtered Rubber Solvent (CHF-32-263).
Filtered rubber solvent showed no genetic activity in Ames assays with
.
4
i
26-60009
Mutagenicity Evaluation of [Shale Oil] R-M. Shale oil R-O4 showed
bacteria Salmonella o r yeast Saccharomyces o r in-vitro mouse lymphoma
celi assays or in in-vivo studies of rat bone marrow celis. Administering
filtered rubber solvent at 0.0834.83 mVkg did not induce dominant
mutagenic behavior in tests with several strains of Salmonella bacteria
i when activated with rat liver extracts, weak mutagenic effects in the
mouse lymphoma celi assay, but no mutagenicity in in-vivo tests
lethality in females mated with these males. The in-vitro tests involved
concentrations of 0.22-1.55% in the bacteria/yeast studies and 0.01 1-1.0%
involving examination of rat bone cell marrow for chromosome in the mouse lymphoma studies. In the bone marrow cell work concentra-
aberrations, or in in-vitro tests with Saccharomyces yeasts. Tables. tions ranged fmm .O83 to 1.66 mVkg of filtered rubber solvent. The
(supported by American Petroleum Institute) bacteriaheast tests were carried out with and without the presence of a
8 API Medical Research Publicarion (Jan. 1978) (150 p.). mouse liver microsome activation system. Tables. (suppoited by
Source: API Library American Petroleum Institute)

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
8 API Medical Research Publication (i0/31/7S) (IS0 p.).
26-60010 Source: API Library
Mutagenicity Evaluation of Stoddard [Solvent] "Fuel". Stoddard
Solvent showed no mutagenic activity in tests with Saccharomyces yeast 26-60017
and bacteria SaInionellu, with or without rat liver activation. or in the Mutagenicity Evaluation of Kerosene. Final Report. Kerosine showed
mouse lymphoma assay, or in in-vivo tests involving examination of the no mutagenic activity or germinal cell effects in a series of in-vivo and
chromosomes in rat bone marrow. Tables. (supported by American in-vitro tests. The in-vitro tests involved Ames assays on yeast Saccharo-
Petroleum Institute) myces and bacteria Salmonella with and without activation by rat liver
8 API Medical Research Publication (Jan. 1978) (150 p.). tissue, and attempted mutation induction in mouse lymphoma cells. In the
Source:API Library in-vivo study the chromosomes of the bone marrow cells from rats
treated with kerosine were examined. Tables. (supponed by the American
Petroleum institute)
26-60011 8 API Medical Research Publication (Mar. 1977) (150 p.).
Mutagenic Evaluation of Rubber Solvent (CHF-32-263). The rubber Source: API Library
solvent CHF-32-263 did not induce significant genetic activity in in-vitro
or in-vivo assays. The in-vitro lests were (1) Ames assays on bacteria 26-60018
Salmonella and yeast Saccharomyces exposed to concentrations of 1-500 Mutagenicity Evaluation of Xylene. Xylene did not show genetic
pl of rubber solvent with and without activation by mouse liver miao- effects in a series of in-vitro and in-vivo tests The in-vitro tests involved
somes, and (2) mouse lymphoma celi assays in the presence of 0.001 to Ames assays with yeast Saccharomyces and bacteria Salmonella with and
1.0% of the rubber solvent. In-vivo tests involved injecting rats with without rat liver activation as weli as assay with mouse lymphoma cells.
0.166-1.66 mVkg of rubber solvent and examining the bone marrow celis The in-vivo studies involve examining of bone marrow celi chromosomes
for chromosome aberrations. Additional lests indicated that rubber of rats treated with xylene at 0.044-0.441 mVkg. Tables. (supported by
soivent did not induce dominant lethality when male rats receiving American Petroleum Institute)
0.083-0.83 mUkg were mated with females after five consecutive days of 8 API Medical Research Publication (Jan. 1978) (150 p.).
treatment. Tables. (supported by American Petroleurn Institute) Source: API Library
8 API Medical Research Publicarion (10/31/19) (150 p.).
Source: API Library
26-60019
Teratology Study in Rats. Toluene. Final Report. Toluene showed no
26-60013 teratologic effect on pregnant rats breathing 100400 pprn for 6 hr/day on
Teratology Study in Rats. Xylene. Final Report. Exposing pregnant days 6-15 of gestation. The rats showed no ill effects and there was no
female rats to atmospheres containing 100 and 400 m m of xylene for 6 evidence of fetal sex ratio variation. embryo toxicity, inhibition of fetal
hr/day on days 6-15 of gestation produced no adverse effects on the growth, or teratogenic potential. (Supported by American Petroleum
mothers and there was no evidence of fetal sex ratio variation, embryo Institute)
toxicity. inhibition of fetal growth, or teratogenic poteniial. Tables. 8 API Medical Research Publication (Jan. 1978) (17 p.).
(Supported by American Petroleum Institute) Source: API Library
8 API Medical Research Publication (Apr. 1978) (38 p.).
Source: AP1 Library 26-60020
Mutagenicity Evaluation of Toluene. In-vitro and in-vivo studies of
26-60014 toluene gave results indicating that the compound does not have
Teratology Study in Rats. Unleaded Gasoline. Final Report. Pregnant mutagenic properties. 'Ihe in-vitro study involved Ames assays with yeast
female rats that were exposed to atmospheres coniaining 400 and 1600 Saccharomyces and bacteria Salmonella with and without activation by
ppm of unleaded gasoline on days 6-15 of gestation showed no evidence rat liver tissue, as well as assay with mouse lymphoma cells. in the
of adverse effects. no fetal sex ratio variation. and no embryo toxicity. in-vivo studies the chromosomes of bone marrow cells from rats treated
inhibiiion of fetal growth, or teratogenic potential. Exposure was 6 with toluene were examined for aberrations. Tables. (supported by
hr/day. Tables. (Suppoited by the American Petroleum Institute) American Petroleum Institute)
8 API Medical Research Publication (Aug. 1978) (23 p.). 8 API Medical Research Publication (Jan. 1978) (150 p.).
Source: API Library Source: APl Library

62

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 O732290 0550022 725 D

26-60021 Institute. Contract U-15-14-PS.5. Incidence of eye and nose irritation


Mutagenicity Evaluation of [Raw Shale] RS-101. Final Report. A in human subjects exposed to 0.60 mgfl. Stoddard solvent or 0.35 mgll.
series of tests indicated that raw shale RS-IO1 may have weak genetic of 70 solvent was only slightly higher than in controls during 30 minute
activity. Ames assays with bacteria SuIntonella and yeast Saccharomyces exposure. ?he olfactory threshold for Stoddard solvent was 0.002 mgll.
gave negative results but suspension tests showed an increase in mutation and that for 70 solvent was 0.003 m d . in a series of 30 second
frequencies with dose for the TA-100 SaIrnonellu strain when activated exposures. 'Ihe solvents had no post-exposure effects. ASTM distillation
with rat liver. Weak and variable mutation increases were also obtained ranges were 322402 "F for the Stoddard solvent and 328-401 O F for the
with two other bacteria strains. Mutation frequencies that increased at the 70 solvent. ?he Stoddard solvent consists mainly of paraffuis (34.9%).
high end of the dose range were also observed in mouse lymphoma monocycloparaffins (34.9%). and aikylbenzenes (22.0%). The solvent
assays. In-vivo work involving rat bone marrow ceii chromosomes gave contains 74.7% aikylbenzenes. 9.3% monocycloparaffins. 6.9% paraffins.
negative results except for one case. The results were, however, strongly and 3.5% naphthalenes. in the tests on the human subjects irritation was
suggestive of genetic activity. Tables. (supported by American Petroleum detennined by subjective reports and by polygraph records of eye blink,
institute) swallowing. and respiration rates. A flow-dilution olfactometer system
= API Medical Research Publicarion (May 1978) (150 p.). was used for all exposures. Tables. (Supponed by the American
Source: API Library Petroleum Institute)
G. P. Cooper;L. Hastings; W. Tanski (Univ. Cinci.), API Medical
26-60022 Research Publicarion (2Iifl6) (7 p.).
Further Investigation on the Effects of Sulfur Dioxide on Human Source: API Library
Subjects. Tests on human subjects showed a significant. reversible effect
on pulmonary function of exposure for 120 hours to 3 ppm sulfur 26-60026
dioxide. Comparison of exposed subjects with controls demonstrated Teratology study in Rats. Stoddard Solvent. Final Report. Pregnant
increased small airway resistance as shown by a difference in compliance rats exposed six hours a day during days 6-15 of gestation to i00 or 400
at high respiratory frequencies. The pattern at both 1 and 3 ppm exposure ppm of Stoddard solvent showed no evidence of variation in sex ratio,
was a large difference in compliance early in the tests becoming less embryo toxicity, or inhibition of fetal development due to the hydrccar-
different from the controls as exposure proceeded through 96 hours but bons. The study involved determining the condition of the visceral and
showing a greater difference after 120 hours. This pattern suggests the thoracic organs of the anesthetized rats on the 201h day of gestation and
effects of reflexive constriction of the airway in the early stages and examination of the contents of the uterus. Tables. (LB1 Project No.
breakdown in the adaptation processes in the later stages at the 3 ppm 20698-2) (Sponsored by the American Petroleum Institute)
level. Subjects exposed for 48 hours to 3 or 6 ppm of sulfur dioxide did W API Meaical Research Publication (10117fl7) (6 p.).
not show complete recovery of frequency dependence of dynamic Source: API Library
compliance in 24 hours after cessation of exposure. Tables and graphs.
(Sponsored by the American Petroleum Institute) 26-60027

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
a E W. Weir. P. A. Bromberg (Ohio State Univ.), MI Medical Acute Toxicity Testing of Shale Oil and Process Materiais. Final
Research Publication (June 1972) (74 p.). Report. Tests of four shale oils, four kerogens. and three spent shales on
Source: API Library rats. rabbits, and guinea pigs, indicated that spent shale can have
significant irritant effects on the eye mucosa of rabbits. shale oil can
26-60023 cause elyihema and edema when applied to the skin of rabbits and
Effects of Sulfur Dioxide on Human Subjects Exhibiting Peripheral application of aii of the materials to the shaved skin of guinea pigs can
Airway Inipairment do not appear to be significantly different from the cause deaths. ?he LD, in rats was 8-10 &g for the shale oil. None of
effects on normal persons. as indicated in studies with persons showing the materials appear to be sensitizers as determined by application to the
definite small airway obstruction in the lungs. The subjects were exposed skin of guinea pigs. In general, the shale materials did not seem to have
to atmospheres containing up to 3 ppm sulfur dioxide over a four week serious toxic effects. Tables and graphs. (Supported by the American
period. The work did show that significant. but minimal and reversible, Petroleum Institute)
effects occur in persons exposed to sulfur dioxide at 3 ppm. but not at API Medical Research Pirblicarion (Mar. 1978) (100 p.).
concentrations below 1 ppm. A complementary blood study of the Source: API Library
plasma from subjects exposed for up to 120 hours to up to 6 ppm of
sulfur dioxide showed an increase of 1.1 nnioles of plasma S-sulfonate 26-60028
for each increase of 1 ppm of sulfur dioxide in the test atniosphere. Investigation of the Potential Hazards of Cancer of the Skin
Graphs, tables. and i0 references. (Sponsored by the American Petroleum Associated with the Refining of Petroleum. Final Report. Extensive
institute) experiments with mice have shown that carcinogenic compounds are
F. W. Weir; P. A. Bromberg; A. F. Gunnison; E. D. Palmes (Ohio present in almost aii refinery streams. that they arise from catalytic
State Univ.), API Medical Research Publication (Sept. 1973) (190 p.). cracking but not thermal cracking, and that they are concentrated in the
Source: API Library streams boiling at 675-1000 O F . The carcinogenicity of the condensed
ring aromatic hydrocarbons c m be increased by as much as a factor of
26-60024 5 by the presence of accelerators such as alkyl aromatics and sulfur
Review of Inhalation Toxicology of Sulfuric Acid and Sulfates. A compounds which are not themselves carcinogenic. The effect of these
review covers chemical mechanisms for oxidation of sulfur dioxide, accelerators can be counteracted by the prrsence of polycycloparaffin.
observations on populations exposed to sulfates. experiments involving Washing the skin of mice with aqueous solution of soap reduced the
acute exposure of human, guinea pigs. mice, rabbits. rats. and cats. and incidence of tumors caused by application of catalytically cracked oil but
chronic exposure studies on guinea pigs, cynomolgus monkeys, rats. effectiveness was lost if the oil was applied with great frequency (more
dogs, and hamsters. It is concluded that acidic sulfate salt of submicron than once a week). Prior rinsing with oil did not increase effectiveness
particle size may be hazardous but that the available information is not of the washing and in some cases had the opposite effect. suggesting that
adequate. Graphs, tables. and 107 references. (Sponsored by the the oil in question contained accelerators. Applying a barrier cream io the
American Petroieuni Institute) skin of the mice prior to application of the carcinogenic oil was of no
M. C. Battigeiii; J. F. Gamble (Univ. N.C., Chapel Hili), A P I Air value. A formula for expressing the carcinogenicity of a petroleum frac-
Qirolity Monograph 75-25 (1975) (89 p.). tion based on its content of benzopyrenes. Dieis-Alder carcinogen, and
Source: API Library "3-1/2ring" carcinogens is proposed. Methods of fractionation. identifica-
tion, and analysis of carcinogens in refinery streams are presented. Tables
26-60025 and 28 references (Supported by American Petroleum Institute)
Dctcctability and Irritability of Hydrocarbons [Stoddard Solvent and rn API Research Project MC-1 Repon (iOí2Ol59) (200 p.).
70 Solvent] in Huinrn Subjects. Final Report to American Petroleuni Source: API Library

63

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 0732290 0550023 b b l

26-60029 26-60032
Effects of Sulfate Aerosols upon Cardiopuln~onary Function in Overview of the Seminar’s Objectives. [Seniinar on Deep Sea Diving
Squirrel Monkeys. Report of Second Year’s Work under APRAC and the Petroleum Industry]. This introduction covers briefly the value
Project CAPM-20-74. Squirrel monkeys have proven to be good of divers, and their cost, safety problems, insurance, heaith problems, and
indicators of the respiratory irritant potency of aerosols; and total- the limits of deep sea diving. Photographs and graphs. (Sponsored by the
respiratory-resistance, forced-pressure perturbation. a good measurement American Petroleum Institute)
technique. In the second year of work under contract to the Coordinating E. L. Beckman (Univ. Tex.), APl Medical Research Reporr EA-7104.
Research Council an esophageal balloon method for pulmonary resistance pp. 1-12 (1972).
and dynamic compliance was also developed. Results obiained with Source: API Library
squirrel monkeys include: ammonium bisulfate and zinc ammonium
sulfate caused statistically significant increases in respiratory resistance 26-60033
at both 10 and 20 Hz. In 40% humidity the irritants had a greater effect Experiments in Human Work Capabilities Under Pressure Now
on resistance than at 85% humidity but the results were not statistically Being Conducted at the Royal Naval Physiological Laboratory
significant; squirrel monkeys’ response to histamine phosphate (a known culminated in exposure of two men to a simulated depth of 1500 feet in
challenge aerosol) was an 80% increase in resistance on injection of the an oxygen-helium atmosphere. Brain adivity measurements showed

--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---
aerosol directly into the mouth; exposure for ten minutes to 200 ppm unusual patterns as a resuit of compression but mental efficiency was
sulfur dioxide gave 1443% increase in resistance, in qualitative unaffected. However, the subjects also developed tremors which
agreement with published results on guinea pigs; ranking of irritant interfered with manual dexterity. The sodium and potassium content of
sulfates by monkeys was the same as from published data on guinea pigs the subjects’ urine also was affected by pressure changes. in other
but the responses were quantitatively smaller. responses of individual experiments rats were compressed to the equivalent of 4000 foot depths,
monkeys showed variability comparable to that in humans. The which resulted in electrical brain activity much like that seen at 1500 ft
experimental methods used are described in detail. Graphs, photographs, in the human experiments. Photographs, graphs, and tables.
tables, and diagrams. 8 P. B. Bennett (R. Nav. Physiol. Lab.), API Medical Research Report
K. A. Bell; J. D.Hackney; E. L Avol: R. M. Bailey; H. L Greenberg, EA-7104, p ~ 13-42
. (1972).
API Medical Research P irblication (6/24/77) (96 p.). Source: API Library
Source: API Library

26-60034
26-60030 Functions Performed by Divers in Offshore Petrdeum Production
The Effects of Oil on Estuarine Aninials: Toxicity, Uptake and include those associated with pipeline operations, platform installation
Depuration, Respiration. Experiments with sheepshead minnows, brown and maintenance, work on drilling rigs, and salvage. The various tasks
shrimp, and grass shrimp exposed to sublethal concentrations of oil performed by divers and the hazards associated with each task are
hydrocarbons. showed that the respiratory response is species-dependent described briefly, as are a number of diving fatalities. Causes of these
and dependent on hydrocarbon composition and concentration. The accidents are indicated briefly.
respiratory response is transitoiy, returning to normal when the animals 8 M. Hughes (Oceaneering Int.). APl Medical Research Report
are returned to oil-free sea water. In 4-hr exposure to i ppm of naphtha- EA-7104. p ~ 55-62
. (1972).
lene or I-methylnaphthalene the minnows accuniulated 200 ppm Source: API Library
I-methylnaphthalene or 60 ppm naphthalene in their tissues, the
concentrations dropping to 10 and 30 ppm. respectively. after 29 hours
in clean sea water. Brown shrimp in contact with the water soluble 26-60035
fraction of No. 2 fuel oil similarly built up high concentrations of The Present and Projected Capabilities of the Diving Industry in the
naphthalene and alkylnaphihalene which dropped to undetectable levels Support of OtTshore Petroleum Production. The long decompression
after 10 hours in oil-free seawater. Accumulation of methylnaphthalenes time for bounced diving at depths in the vicinity of 600 feet make
was considerably greater than that of either naphthalene or dimethylnaph- saturation diving preferable, and this technique is safer even at 200 feet.
thalenes. l h e 24 hour LC, value of the three species for naphthalene, There is a need to develop appropriate equipment standards as well as a
1 -methylnaphthalene. 2-methylnaphthalene and dimethylnaphthalenes was good heated suit and a comfortable helmet with good communication and
determined. The test material, provided by the American Petroleum satisfactory safety system. Diving limits appear to 300 feet for nitrogen-
Institute, included two crude oils (South Louisiana and Kuwait). a high oxygen atmosphere, 2500-3009 feet for helium-oxygen. and 5000á000
aromatic No. 2 fuel oil, and a Venezuelan Bunker C oil. Tables. graphs, feet for hydrogen-oxygen. Experience in the Janus II 840-foot saturation
and 20 references. dive and in the Physalie IV simulated 1700-fooi dive is reported. It is
J. W. Anderson: J. M. Neff; B. A. Cox; G. M. Hightower. H. E. also noted that baboons have been compressed to the equivalent of 4ûOû
Tatem (Tex. A&M Univ.). in Pollirrion and Physiology of Manne feet in a helium breathing mixture and monkeys have been kept for up
Organisms, ed. F. J. Vernberg and W. B. Vemberg, pp. 285-310 (New to six hours at the equivalent of 2500 feet in a nitrogenaxygen
York: Academic, 1974). atmosphere. Photographs and graphs.
Source: Not available from APi H. G . Delauze (COMEX), API Medical Research Report EA-7104. pp.
63-78 (1972).
26-60031 Source: API Library
Occupational Safety and Health Problems of the Diving Industry in
Offshore Petroleum Production. A seminar on diving includes papers 26-60036
on experiments canied out at the Royal Naval Physiological Laboratory Deep-Water Petroleum Production Systems. The Humble subsea
and at the University of Pennsylvania. functions perfomied by divers in production system has been designed to operate in depths of 1500 feet
offshore petroleum production. capabilities of the diving industry. for the anticipated life of an oilfield. Maintenance of the equipment is
description of a deepwater petroleum production system. implications of conducted in the open sea environment. It has a manipulator system for
the Occupatimal Safety and Health Act of 1970, safety problems in opening and closing production valves, replacing valve operators. making
diving, unknowns in decompression table calculation. aseptic bone and breaking connectors, and recovering control pods as part of
necrosis in divers, and discussion of diving problems and solutions in maintenance. It can be operated from the surface by means of television
offshore petroleum operations. (Sponsored by the American Petroleum cameras but the equipment also has a diving bell for inspection. Special
Institute). operations will be done by means of a submersible or divers.
E. M. Smith; E. L. Beckman (Univ. Tex.). API Medical Research L J. Snyder (Humble Oil & Refining Co.). API Medical Research
Report EA-7104 (1972) (155 p.). Report EA-7104, pp. 79-81 (1972).
Source: API Library Source: API Library

64

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLm4634 95 0 7 3 2 2 9 0 0550024 5 T 8 =

26-60037 bad diving experience. Furthermore, there appean to be no relation to


implications of the Occupational Safety and Health Act of 1970 past decompression sickness. Treatment of necrosis consists of keeping
[OSHA] to Industry. A survey includes: who is covered by OSHA, the patient from putting any weight on the affected joints. If deterioration
employee and employer requirements and rights. health and safety of the joint has set in surgery and prostheses is required, and this must
standards, criteria for compliance. inspection procedures, penalties, effect be repeated after ten years. Because of the possible length of iime
on existing workman's compensation laws, and the mission of the between exposure and development of symptoms. the cost of this disease
National Institute for Occupational Safely and Health. to the diving industry and to the insurance companies can be very high.
E. J. Fairchild (NIOSH). A P I Medical Research Reporr EA-7104, pp. It is recommended that research be directed to measurements of nitrogen
83-90 (1972). and helium elution from body tissues, that mathemaiical models be
Source: API Library abandoned. and that a ceniral registry be set up containing X-rays of all
divers and complete records of ail diving activities for each penon.
26-60038 X-rays patterns.
Medical Implications of the Occupational Safety and Health Act in E. P. Kindwall (Saint Luke's Hospital, Milw.), API Medical Research
the Diving Industry fall into three categories: recognized dangers that Report EA-7104, pp. 12540 (1972).
result from the offshore marine environment; hazards related to decom- Source: API Library
pression sickness; and problems requiring more information. such as
chronic toxicology under high pressure. treatment of injuries and illness 26-60043
under high pressure, and possibility of acute toxicity (convulsions) at The Effect of a Rapid 4% Carboxyhemoglobin Saturation Increase
higher pressures than presently encountered. Graphs. on Maximal Treadmill Exercise. Tests on six physicaiiy fit firefighters
H. W. Gillen (Marine Technol. Soc.). API Medical Research Reporr showed that rapid increase in carboxyhemoglobin resulted in a decrease
EA-7104, p ~ 91-97
. (1972). in the time to exhaustion in exercise tests, although in 16 of the 44
Source: API Library measurements exposure to carbon monoxide resulted in improved
performance. The tests involved breathing 20,000ppm carbon monoxide
26-60039 for 45 seconds followed by 30 ppm for four hours, after which the
Implications in the Occupational Safety and Health Act of 1970 Upon subjects were exercised to exhaustion on a treadmill. The carbon
the Operational Costs of Diving Services. Because the new safety law monoxide exposure also produced an increase in heart rate from 177.7
requires additional safety equipment and more frequent equipment to 179.3, an increase in the volume of expired air from 127.2 to 131.4
testing, higher standards. more comprehensive record keeping and ]./min and a decrease in amrial oxygen pressure at 50% oxyhemoglobin
reporting. and more training of personnel. the costs of equipment. base saturation from 27.5 to 26.3 mm Hg of mercury. There was no evidence
facilities. administrative overhead. recruitment training. medical coverage, of adaptation and no significant changes in systolic time intemals. Graph,
and equipment maintenance wili trend upward. The cost trends of tables, and 22 references. (Supported by the Coordinating Research
insurance and of research and development will be down. The trend of Council)
diver's wages and of the cost of consumables and transportation will be R. D.Stewart; P. E. Newton; H. V. Forster, C. L. Hake; J. Kaufman;
unchanged. M. H. Keelen; J. P. Klein; D.J. Stewart; A. Wu (Med. Coli. Wisc.), APf
J. A. Lawrie (Ocean Syst. Inc.). API Medical Research Repori Medical Research Publication; Repori No. CRC-APRAC-CAPM-22-75
EA-7104, p ~ 99-105
. (1972). MCOW-ENV (1979) (43 p.),
Source: API Library Source: API Library

26-60040 26-60051
Occupational Safety Problems in the Diving Industry. The sources of Mutagenicity Evaluation of Raw Shale. Final Report. Raw shale
danger to the diver are categorized as: the diver himself by taking risks; showed a clastogenic effect in in-vivo tests involving chranosome
the contractor who, for example. does not have a deck decompression abemtions in rat bone marrow cells. No mutagenic effects were found
chamber. the type of boat or platform from which the diving is done, in in-vitro tests: (1) Ames assays using bacteria Salmonella and yeasts
especially a moving boat: layout of equipment on the barge; inadequate Saccharomyces with or without rat liver tissue activation; (2) mouse
conirnunication among crew niembers and between management and lymphoma assays. Tables (supponed by the American Petroleum
barge crew members and divers before and during the job; weather and Institute)
tide, which cause changes in temperature. current. visibility. and surface API Medical Research Publicalion (May 1978) (150 p.).
conditions. Photographs. Source: API Library
m R W Honaker (J & J Marine Diving Co. Inc.). API Medical Research
Reporr EA-7104. pp. 107-16 (1972). 26-60045
Source: API Library Effects of Oxides of Nitrogen, Carbon Monoxide and Photochemical
Oxidants on the [Elecîrocardiogram] during Exercise and on
26-60041 Cardiopulmonary Function. Final Report (APRAC Project
T h e Unknowns in Deconiprcssion Table Calculation and Their CAPM-21-71). Exposure of human volunteers to 0.2 ppm ozone fortwo
Implications in Occupational Safety and Health. The types of data hours with intermittent light exercise and heat stress showed no adverse
needed to be able to establish safe diving conditions are discussed. It is effect of ozone on arterial oxygenation or on pulmonary function.
stated that twice as much bottom iime as most diving companies current Separate blood measurements were made on samples drawn from the
permit is probably safe. brachial artery and on "arterialized" blood collected from the earlobe.
P. O. Edel (Hydrospace Co.). API Medical Researcli Repon EA-7104. Diagram, graphs, tables, and 15 references.
pp. 117-23 (1972). W. S . Linn; J. D. Hackney. API Medical Research Publicaiion
Source: API Library ( 5 n i í l 8 ) (50 p.).
Source: API Library
26-60042
Aseptic Bone Necrosis Occurring in Persons Who Work under 2640048
Pressure. A discussion states that aseptic bone necrosis among divers "Normal" Carboxyhemoglobin [COHb] Levels of Blood Donors in
generally occurs as the result of failure to carry out correct decompres- the US. were surveyed by the Medical College of Wisconsin for the
sion after a dive. The lack of good decompression data and the fact that Coordinating Research Council Inc. and the US. Environmental
bone lesions may occur without creating immediate symptoms compli- Protection Agency in 1%9-72. COHb analyses of venous blood samples
cates the problem. There is. however. no record of aseptic necrosis taken from 29.000 adults residing in or near 17 large cities, from 1525
occuning from dives to depths of less than 38 FSW. However, divers in adults in 13 small communities in Vermont and New Hampshirc, and
apparently good health may show symptoms in X-rays five years after a from 4 donors voluntarily breathing CO-free air showed that 45% of aii

65
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API PUBLJ4634 95 = 0 7 3 2 2 9 0 0550025 434 W

the nonsmoking blood donors had COHb saturations of < 1.5%. Carbon levels of them may be too low to account for the observed degree; eye
monoxide analyses of alveolar breath samples from every tenth donor irritants are formed only by photochemical reactions; panicuiates do not
were also performed. Smoking was the most important factor responsible cause eye irritation; atmospheric levels of irritants produce no visible
for the highest COHb saturations: other factors influencing the COHb changes in the eyes of humans or rabbits and do not deactivate sulfhydryl
saturation were geographical location, occupation. and existing meteoro- enzymes; lysozyme levels in the tears of sensitive individuals exposed to
logical conditions. None of the large urban conimunities had CO Los Angeles smog are lower than normal because of a subnormal flow
concentrations below enough to comply with the ambient air quality of lysozyme tears; no objective method of measuring eye irritation has
standards. Graphs, tables, and I5 references. been devised and correlations with the oxidant level are questionable;
B R. D. Stewan; E. D. Baretta; H. C. Dodd; K. K. Donohoo; S. A. individuals vary greatly in their sensitivity to eye irritation; and synthetic
Graff; J. H. Kalbfleisch; L. R. Platte; E. B. Stewan (Med. Coil. Wis.). smog cannot duplicate the effects of natural smog. Additional research
API Medical Research Publication #4183 (May 1973) (240 p.). projects are suggested. Graphs, tables. diagrams, and 95 references.
Source: API Library K. W. Wilson (Copley Int. Corp.), MI Medical Research Publication
(Apr. 1974) (72 p.).
26-60049 Source: API Library
[In a Two-Year] Investigation of the Effects of Carbon Monoxide on
[10] Humans in the Driving Task, under contra& to the Coordinating 26-60053
Research Council Inc., and funded by the U.S. Environmental Protection The Use of Panelists as Substitutes for Taxicab Drivers in Carbon
Agency, API, and the Motor Vehicle Manufacturers Association, the Monoxide Exposure was investigated for the Coordinating Research
effects of O, 7, 14, and 2Dcio carboxyhemoglobin (COHb) levels on Council Inc. and the U.S. Environmental Protection Agency by analyses
physiological performance, complex psychophysiological and psychomo- of breath and limited blood samples from 30 pairs of taxi drivers and
tor skills. and driving skills and judgement on the highway were panelists who drove in New York City traffic for eight hours in two
determined. In general. no ostensible performance degradation was consecutive days. Both panelists and drivers attained similar blood
observed with C O W in normal driving tasks although subtle perfor- carboxyhemoglobin (COHb) levels. This was true for both smokers and
mance losses were observed, especially in information acquisition tests. nonsmokers, though smokers had significantly higher COHb mncentra-
With heavy information processing demands and/or other associated tions than nonsmokers. There was no consistent difference between the
debilitating factors in driving, such as fatigue or alcohol. these subtle first and second day of driving in the levels of alveolar carbon monoxide.
effects could be compounded into gross performance changes. Tables, The use of alveolar air to indicate the probable levels of COHb was not
charts, graphs. data forms, and 69 references. a viable assumption since carbon monoxide concentrations in alveolar air
F. W. Weir. T. H. Rockweil (Ohio State Univ.), API Medical did not correlate weil with COHb under the conditions of this study.
Research Publication #4 I190 (Jan. 1973) (176 p.). Expanded use of the finger-prick method will probably be more
Source: API Library satisfactory. Tables and graphs.
A. W. Hoover; R. M. Albrecht (Columbia UNV.), MI Medical
26-60050 Research Publication #4214 (July 1973) (31 p.).
Effects of Oil and Cheniically Dispersed Oil on Selected Marine Source: API Library
Biot &.A Laboratory Study. In a study by the Battelle Memorial
Institute. Pacific Nonhwest Laboratories for API. the lethal dose of No. 26-6005-1
2 fuel oil and South Louisiana and Kuwait crude oils was determined for
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

The Effect of Carbon Monoxide Inhalation on Induced Ventricular


13 fish, 5 crustacea. 3 niollusca. and 2 algae by a flow-through bioassay Fibrillation in the Cynomolgus Monkey. In a study performed by
method; the fuel oil was more toxic than the crudes. Sublethal and Thomas Jefferson University for the Coordinating Research Council Inc..
chronic effects were studied by observing alkane and methylnaphthalene normal monkeys and monkeys with acutely induced myocardial infarction
uptake and depuration by oysters over a 28 day period. Uptake dropped were immediately exposed to i00 ppm carbon monoxide for six houn.
after 2 days of continual exposure, apparently due to biological distur- Blood carboxyhemoglobin at the end of the exposure period ranged fran
bances such as decreased feeding, but then increased directly with 7.6 to 12.3% with a mean of 9.2%. In noninfarcted air-breathing animals,
exposure. Depuration was rapid when the oysters entered clean water. ventricular fibrillation was induced electrically at 78.5 v; in air-breathing
The extraction and measurement procedures were devised and validated infarcted animals at 50.6 v; in noninfarcted animals exposed to carbon
for C,,-C, n-alkanes and methylnaphthalenes in biological tissues. monoxide at 45 v; and in infarcted animals exposed to carbon monoxide
Oysters exposed to Kuwait crude showed no pathological damage. at 30 v. Thus, both myocardial infarction and carbon monoxide inhalation
Tables, graphs. and 81 references. enhance the vulnerability of the ventricle to induced fibrillation. The two
8 API Medical Research Publicaiion #I4191 (i 1/1/73) (87 p.). effects appear to be additive since no significant interaction could be
Source: API Library demonstrated. Tables, electrocardiograms, diagram, graph, and 16
references.
26-60051 D. A. DeBias; C. M. Banerjee (Thomas Jefferson Univ.); N. C.
[In] a Program for Upgrading the NO, Instrumentation Employed in Birkhead (U.S.V. Pharmaceutical Corp.), API Medicol Research
the 1972 Chattanooga NO, Exposure Study by the Research Triangle Publication U4228 (July 1973) (34 p.).
Institute for the Coordinating Research Council Inc. chemiluminescent Source: API Library
monitoring instrumentation for nitric oxide. nitrous oxide, and nitrogen
oxides and automatic data acquisition systems were installed in appropri- 26-60055
ate shelters ai seven of the nine niooring sites in Chattanooga. After Laboratory Studies on the Effects of Oil on Marine Organisms: An
checkout. chemiluminescent nitrous oxide field data were obtained for Overview of studies conducted over a two-year period by Texas A&M
seven months from two sites and for six months at the other five sites University for the American Petroleum Institute showed that in bioassay
during the year Apr. 1972 to Apr. 1973. Tables, flow chan. diagrams. tests with phytoplankton, crustaceans. and fish, the toxicities of oil-water
phoiographs. graph. map, and 16 references. dispersions and water-soluble fractions from refined oils were significant-
B C. E. Decker. T. M. Royal: J. B. Tommerdahl (Res. Triangle Inst.), ly greater than those from crude oils. Of the physiological responses
API Medical Research Publication #4202 (1973) (99 p.). studied in relation to the sublethal concentrations of hydnxiarbais,
Source: API Library respiration seemed most inmnsistent, although heartbeat rate of fish
embryos and growth rates appeared to be most productive. AU species
26-60052 were shown to release accumulated hydrocarbons, including
A Survey d Eye Irritation and Lachrymation in Relation to Air benzo[a]pynne. when maintained in clean water. In uptake and release
Pdlution was conducted by Copley Intemational Coip. for the Coordi- studies, the naphthalenes, which were shown to be quite toxic. were
nating Research Council lnc. It concluded that formaldehyde, acrolein, accumulated to the greatest extent in ail test species and retained the
and peroxyacetyl nitrate may contribute to eye irritation but atmospheric longest, but the process was reversible. Graphs, tables, and 42 references.

66

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L o 4 6 3 4 95 = 0732290 0550026 370 9

m J. W. Anderson (Tex. A&M Univ.), API Medical Research type analysis, trace element content, distillation data, "EPA Toxic
Publication #4249 (1 1/1L'3) (7%). Metals", refractive index, density, viscosity. pour point. BS&W.
Source: API Library molecular weight. elemental analysis. and asphaltenes/carbenes/~~ids/
resins/oil fractionation data. The analytical methods used are described
26-60057 in detail. Tables, electron micrographs, and graphs. (Report to the
Ambient Air Quality Standards for Particuiates...Review and American Petroleum Institute)
Evaluation. A review covers the physical and chemical properties of L. W. Burdett (Union Oil Co. Calif.), API Report (9/iL'8) (75 p.).
particulates; undesirable effects of particulates in relation to the establish- Source: API Library
ment of air quality standards; particulates and reduction in visibility;
soiling or nuisance problems from particulates; and existing ambient air 26-60064
quality standards for particulates. Graph. tables, and 33 references. Air Quality Standards for Lead. A review covers the effects of
H. C. McKee (Southwest Res. Inst. - Texas Air Control: Board), MI exposure to lead on human health: lead levels in biological samples;
Air Qualiry Monograph 69-1 (Feb. 1969) (28 p.). atmospheric lead levels; and proposed air quality standards. 51 rrferenc-
Source: API Library es. (supported by American Petroleum Institute,)
R. G. Smith (Wayne State Unk.), MI Air Quality Monograph 69-11
26-60058 (Feb. 1969) (i5 p.).
Particulates: Air Quality Criteria Based on Health Effects. A review Source: API Library
covers the acute effects of the experimental inhalation of particulates.
including physiological effects on the airways in terms of increased 26-60065
airway resistance. minor changes in compliance and disturbance of Arsenic. A survey covers sources and uses of arsenic; o c c u m c e of
ventilation uniformity; the chronic effects of dusty air, including arsenic in air, water, soil. food, and drink; methods of analysis; chemistry
deposition of suspended matter (black pigment) in the lungs: and gas and and biochemistry of arsenic; arsenic toxicity and pharmacology; air
particulate interaction, in which adsorption may modify the site of gas quality standards for arsenic: and peninent literature reviews. Tables and
absorption in the respiratory system. Diagrams, table. and 30 references. 87 references.
(supported by American Petroleum Institute) m B. L Vallee (Harv.Med. Sch.),MI Air Quality Monograph 73-18
m M. C. Battigelli (Univ. N.C. Sch. Med.). API Air Quality Monograph (1969) (36 p.).
69-2 (Feb. 1969) (15 p.). Source: API Library
Source: API Library
26-60066
26-60060 Phosphorus. A review covers the presence of phosphorus in the
Oxidants: Air Quaiity Criteria Based on Health Effects. A review environment; its production and industrial sources (including oil and
covers smog photochemistry; total oxidant (ozone), including environ- petroleum produas): methods of analysis: chemistry; nutrition and
mental considerations and health effects; nitrogen oxides, including biochemistry of phosphorus and its derivatives; and toxic effects of
environmental considerations and health effects; hydrocarbons. formalde- phosphoms and its compounds. Tables and 39 references.
hyde, and polynuclear hydrocarbons: and criteria for the control of B. L. Vallee (Harv. Med. Sch.), API Air Quality Monograph 73-19
photochemical smog and oxidant concentrations. Graphs. tables, and 51 (1973) (39 p.).
references. (supported by American Petroleum Institute) Source: API Library
1. R. Tabenhaw; F. Ottobni; W.C.Copper (Univ. Calif. Berkeley).
API Air Quality Moriograpli 69-5 (Feb. 1969) (36 p.). 26-60067
Source: API Library Lithium. A survey briefly covers types of lithium minerals, lithium
occurrence in water, soils, and plant and animal tissues, with data on
26-60061 lilhium concentrations in water in cities that are close to lithium deposits
A Review of the Toxicology of Lead covers the sources of environmen- and others that are at a distance, as well as concentrations in the different
tal lead; body storage of lead; biochemical aspects of lead in the body; types of tissues of humans under treatment with lithium; analytical
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

sources of lead overexposure: pediatric plumbism: adult plumbism; lead methods and chemical properties of lithium; biochemical effects,
alkyl intoxication: and air quality criteria. Tables and 287 references. physiological effects, and toxicology. Tables and 37 references. (Support-
(supported by American Petroleum Institute) ed by the American Petroleum Institute)
T. J. Haley (Univ. Hawaii Sch. Med.). API Air Quality Monograph B. L Vallee (Harv. Med. Sch.). API Air Qirality Monograph 74-20
69-7 (Feb. 1969) (53 p.). (Aug. 1974) (16 p.).
Source: API Library Source: API Library

26-60062
Air Quality Standards for Carbon Monoxide. A review covers the 26-60068
existing levels of carbon monoxide and the health effects resulting f r a n Copper. A survey covers the occurrence of copper in air, soils. rocks,
long-term, lowancentration exposure to carbon monoxide alone or and water, including atmospheric concentration data for many locations
combined with other pollutants. as related to the establishment of air in the U.S.A. and concentrations in the waten of 16 U.S. river basins;
quality standards and methods of measuring atmospheric carbon uses. analytical methods, and chernical properties of copper. presmce in
monoxide concentrations. Graphs, tables, and 20 references. (supported biochemical systems such as enzymes and proteins and concentration in
by American Petroleum Institute) dry tissue of various plants; physiology and metabolism; nutritional
U. G. Smith (Wayne State Univ.). API Air Qitality Monograph 69-9 requirements; copper toxicity and relationship to human disease. Tables
(Feb. 1969) (20 p.). and 41 references. (Supported by the American Chemical Institute)
Source: API Library B. L. Vallee (Harv. Med. Sch.). API Air Quality Monograph 75-21
(1975) (32 p.).
26-60063 Source: API Library
Comprehensive Analysis of Shale Oil Products (Revised). Extensive
analytical data and measurements are reported for four raw shales. four 26-60069
spent shales. and four shale oils. Data on the shales included Fischer Tin. A survey covers the forms and concentrations of tin in rocks, plants,
assay, particle size distribution. minerai composition, "EPA Toxic animals, and the air. including air analysis figures for 196667 for 137
Metals". elemental analysis. trace element analysis. surface area deter- sites in the U S ;methods of analysis; physical and chemical properties;
mination. benzene extractabler content, electron phoioniicrographs. and nutritional requirements; and toxicity. Tables and 24 references.
qualitative X-ray data. For the shale oils the report presents hydrocarbon (Supported by the American Petroleum Institute)

67

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L b 4 b 3 4 95 O732290 0550027 207

B. L. Vallee (Harv. Med. Sch.). MI Air Quality Monograph 75-22 rai Healih Supplement 2: 69-105 (1977).
(1975) (13 p.). Source: Not available from API
Source: API Library
26-60074
26-60070 Benzene Toxicity. A Critical Evaluation is presented based on a review
Gaseous and Particulate Sulfur Compounds in Urban Atmospheres. of world literature. including chapters on analytical techniques, benzene
A review covers the types and concentrations of gaseous and partinilate metabolism, the molecular mechanism of the toxicity, experimental
sulfur compounds in the atmosphere, their sources and emission rates, the intoxication. cytologic and cytogenic effects, and human hematotoxicity
cycle of supply and removal of sulfur in the atmosphere. measurement in separate chapter. 1003 references (Supponed by the American
of atmospheric sulfur dioxide and sulfate concentrations. relationship to Petroleum Institute)
urban weather factors, general characteristics of urban atmosphere and of S . Laskin B. D. Goldstein, Journal of Toxicology and Environmenml
urban aerosols, a model for urban sulfur aerosol formation, and vehicle Health Supplemenr 2 (1977) (147 p.).
emissions of sulfur oxides and sulfate. Graphs. tables. and 7 0 references. Source: Not available from API
(Supported by the American Petroleum Institute)
E.Robinson (Wash. State Univ.), API Air Quality Monograph 75-23 26-60075
(1975) (48 p.). Analytical Techniques [for Benzene] are reviewed, including methods
Source: API Library for industrial gases, organic solvents, air. water, and biological systems.
The best methods are nonvisible spectrophotometiy when there are few
26-60071 interfering compounds,and gas chromatography in complex mixtures and
The Long-Term Effects of Sulfur Dioxide on Ciliary Activity in the biological systems. Tables and 271 references (Supported by the
Trachea. A research project sponsored by the American Petroleum American Petroleum Institute)
Institute and camed out at the University of North Carolina was m C.A. Snyder (N.Y. Univ.), Joirrnal of Toxicology and Environmental
developed to identify the pathogenetic steps in sulfur dioxide injury. The Health Supplement 2:5-22 (text), 107-18 (refs.) (1977).
respiratory surface was selected as the most probable site of effect. Rats, Source: Not available from API
hamsters, and mice have been exposed to sulfur dioxide at 1 ppm,
simultaneously with 1 mg/cu m of graphite or calcium sulfate dust, for 26-60076
12 hr daily, 7 days/week, for up to 4 mo. The ciliary activity. the [A Review ofl Benzene Metabolism covering in-vivo and in-vitro
microflora of the respiratory surfaces. the weight of the whole animal studies including metabolism in humans and bacterial systems, concludes
body. the weight of the major parenchymal organs, the hematocrit,and the that the pathways are similar in humans and au animal species. The
relative histology have been used as the indexes of injury. AU indicators major differences arise from the conjugation of the final metabolites.
concurred to minimize significant pathological effect on the respiratory sulfonation being the predominant form in human and glucuronide
surfaces; apparently something different and more complex than the formation occurring only when the sulfonation route is heavily utilized.
effect of sulfur dioxide on the surface of the respiratory apparatus is Chronic toxicity is related to the levels of metabolites present. Treatments
responsible for the casualties from air pollution exposure. Graphs, that increase elimination of the metabolites and thus, decrease toxicity.
diagrams. tables, and 11 references. Decreasing the rate of metabolism of benzene lowers the level of
m M. C. Battigelli; D. A. Fraser (Univ. N.C.). M / Medical Research metabolites in some cases and sometimes decreases the chronic toxicity.
Repor1 EA7101 (1971) (72' p.). Treatments do not. however, alter the acute toxicity of benzene. 90
Source: API Library references. (Supported by the American Petroleum Institute)
G. M. Rusch; B. K. J. Leong; S. Laskin (N.Y. Univ.), JournaI of
26-60072 Toxicology and Environmental Health Supplemenr 2:23-26 (1977).
Uptake and Depuration of Specific Hydrocarbons from Oil by the Source: Not available from API
Bi-valves Rangia cuneata and Crawostrea Virginica. Laboratory
studies were done on groups of clams (¡.e.. Rangiu) and oysters (¡.e., 26-60077
Crassostrea) by exposing them to oil-water emulsions of four test oils for [A Review on] Experimental Benzene Intoxication covers acute,
1-7 days. Some of the oysters were allowed to depurate for up to 52 subacute, and chronic toxicity induced by inhalation; intoxication by
days. South Louisiana crude oil, Kuwait crude oil. No. 2 fuel oil, and parenteral and oral administration; the sequence of hemopoietic changes;
Venezuelan bunker C oil were used as the test oils. Detailed analyses the immunological effects; attempts to induce leukemia with benzene:
were made of specific hydrocarbons present in the tissues of the animals. embryonic and teratogenic effects: and biochemical and histochemical
The levels of hydrocarbons accumulated in the tissues were related to the effects. Tables and 65 references. (Supported by the American Petroleum
concentration of water-soluble fractions plus the amount of droplet Institute)
dispersion. Both aromatic and saturated hydrocarbons are released from m B. K. J. b o n g (N.Y. Univ.), Journa/ o/Toxico/ogy and Environmen-
the tissues relatively rapidly, such that maintenance in clean water for rol Health Supplement 2:45-61 (1977).
periods of 24-52 days is sufficient to cleanse the tissues of detectable Source: Not available from API
levels of hydrocarbons. Graph and tables.
m J. W.Anderson, U.S.Narioid Technical Informarion Service AD-183 26-60078
990. pp. 690-708 (May 1973). T h e Molecular Site of Benzene Toxicity. A review of the literature on
Source: Not available from API the molecular mechanism of benzene toxicity indicates that the action is
probably not in DNA and RNA synthesis but in the process of protein
26-60073 synthesis. Evidence suggests that the primary toxic effect is inhibition of
[A Review on] Heniatotoxicity in Humans covers pancytopenia, heme synthesis occurring at or before ALA (aminolevuiinic acid)
leukemia, and other hematological diseases that appear to be associated synthetase. Studies in vitro with rabbit reticulocytes suggest that there
with exposure to benzene; clinical manifestations and outcome; cellular may be imponant relationships among heme synthesis, cyclic AMP, and
effects of benzene in the blood; incidence of benzene-induced leukemia pyridoxine metabolism. 35 references. (Supported by the American
and studies on the relationship of leukemia to benzene exposure; case Petroleum Institute)
reports of other blood diseases apparently induced by benzene; individual m M. L. Freedman (N.Y. Univ.). Jouriwl of ToxicologyandEnvironmen-
factors in susceptibility to benzene, such as heredity. sex. age. and status tal Health Supplement 2:37-43 (1977).
of the hematopoietic system: and early detection of toxicity. Extensive Source: Not available from API
tables summarizing individual reports of various types of benzene-related
hematotoxicity are presented. 100 references. (Supported by the 26-60079
Amencan Petroleum Institute) Effects of Oxidant Leveis on Selected Health Characteristics of
B. D. Goldstein (N.Y. Univ.), JoirrnaI o/Toxicology and Environmen- Persons in the Los Angeles Baiin. First Annual Report. Volume 1.

68
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 0 7 3 2 2 9 0 0550028 143

Data Collection. In an attempt to relate respiratory illness to air discomfort in 15 minute inhalation of 460 ppm. Tables. (Suppoited by
pollution, data on chronic and acute respiratory disease and asthma the American Petroleum Institute)
symptoms have been collected by means of questionnaires and telephone C. P. Caipenter, E. R. Kinkead; D. L Geary: J. M. King; L J.
interviews in three communities in the Los Angles area. In addition, Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and Applied Pharma-
pulmonary function has been evaluated by measuring forced expiratory cology 33543-58 (1975).
volume within 0.75 second in more than SO00 elementary school children Source: Not available from APi
in the three communities (90% of the school population). Details are
presented on the populations surveyed. the questions asked, and the
techniques used by the University of California at Riverside to monitor 26-60081
air quality in these conimunities. Photographs. graphs, and tables. (Report Petroleurn Hydrocarbon Toxicity Studies-6. Animal and Human
prepared for Coordinating Research Council and Environmental Responses to Vapors of "60 Solvent". A standard of 90 ppm was
Protection Agency) proposed based on animal response results to "60 Solvent" vapor, even
API Publication #4229 (4/7/73) (44 p.). though 350 p p n was well tolerated by humans. Rats were affected at 170
Source: API Library ppm. T h e LC50 for rats that inhaled vapor for four hours was 4900 ppm,
whereas 690 ppm caused no visble response. Similar responses occurred
26-60080 in beagles at 1900 and 820 pprn. respectively. Cats died within four
Studies on the Toxicity of Petroleum Waues. Chemical and animal hours at 4100 ppm. The M O for rats was 150 minutes at 7700 ppm.
studies showed no carcinogenic hazard from petroleum waxes used for There were no erythrocyte fragility effects in rats exposed to 9200 ppm.
food packaging. Five waxes fed to rats at a 10% level in the diet over Upper respiratory tract imtation in mice was not observed below 1200
two years were harmless. Subcutaneous implantation of five waxes as ppm. After 65 exposures of six hours per day, the only effeds observed
discs and the aromatic and nonaroniatic fractions of one wax as powders in beagles were slight increases in liver and kidney weights at 1200 ppm.
caused fibrosarcomas, which were ascribed to the physical rather than In similar tests. rats showed kidney damage even at concentrations as low
chemical properties of the waxes. Repeated skin application of benzene as 41 ppm. Human volunteers detected odor at 180 ppm. Five of the six
solutions of wax and aromatic and nonaromatic fractions had no volunteers thought that 340 ppm would be tolerable over an eight-hour
carcinogenic effect on mice or rabbits. Dibenz[a,h]anthracene added to working day. The "60 Solvent" has an ASTM boiling point of 263-319
wax was extensively eluted in the gut of rats and mice but only 6-20% OF. and contains 30% paraffins, 19% monocyclopraffns, and 51%
passed into the body and none of it was present as free hydrocarbon. alkylbenzenes. (Supported by the American Petroleum Institute)
Polycyclic aromatic hydrocarbons added to wax are eluted by both the C. P. Carpenter, E. R. Kinkead; D. L Geary; J. M. King; L J.
fat and protein in milk. but very little of the eluted compound remains Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and Applied Pharma-
as free hydrocarbon. Elution is much greater from paraffin than from cology 34374-94 (1975).
microcrystalline wax. Analysis of 36 wax samples showed the presence Source: Not available from API
of benz[a]aníhracene, benzo[e]pyrene. chrysene. fluoranthene. pyrene, or
triphenylene in eight instances. at a maximum concentration of 0.64 ppm. 26-60085
(Supported by the American Petroleum Institute) Petroleum Hydrocarbon Toxicity Studies-7. pests of] Aninial and
P. Shubik: U. Safiotti: R. Feldman: W. Lijinsky; A. Pietra; C. R. Human Response to Vapors of "70 Solvent" led to a proposed
Raha: H. Ramahi; H. Rappaport: L. Tomatis: B. Toth (Chic. Mech. Sch.). hygienic standard of 59 ppm. Inhalation of 810 ppm for eight hours
Toxicology and Applied P karniacologv Supplement 4: 1-59 (Nov. 1962). caused no deaths in rats, whereas four-hour inhalation of 930 ppm caused
Source: Not available from API some deaths in beagles. There were signs of central nervous system
effects in cats that inhaled 370 ppm for s u hours. No eghrocyte
26.60082 fragility effects were observed in rats exposed to 780 ppm. T h e lowest
Petroleum Hydrocarbon Toxicity Studies-l. Methodology. Techniques concentration that caused mouse respiratory tract imtation was 280 ppm.
and equipment to be used in studies of the inhalation toxicity of a series Exposure for six hours per day for 65 days caused body weight decreases
of petroleum hydrocarbons are described. including procedures for acute in rats and in dogs as well as liver weight decreases in dogs. "Challenge"
inhalation toxicity of rats, subacute inhalation toxicity of rats and dogs, concentrations of 1100 p p n for six hours showed no effects of prior
mouse upper respiratory tract initation, and human sensory response exposure to 70 Solvent in rats. Humans detected odor at between 0.1 and
pmcedures: equipment and techniques for supplying vapor-air mixtures 1.0 ppm, and concentrations of 59 ppm had no serious effects. The "70
to the test animals: sources, feed. and husbandry of the rats and dogs: Solvent" has an A S T M boiling range of 315-411 "F and contains about
analytical chemistry techniques: and procedures to detemiine health 24% paraffins, 12% monocycloparaffins. and 64% alkyl benzenes.
effects such as hematology and histological methods. Diagrams, graphs. Tables. (Supponed by the American Petroleum Institute)
tables, and 15 references. (Supported by the American Petroleum C.P. Carpenter, E.R. Kinkead; D. L. Geary; J. M.King; L J. Sullivan
Institute .) (Carnegie-Meiion Inst. Res.), Toxicology and Applied Pharmacology
C. P. Carpenter, E. R. Kinkead; D. L Geary: J. M. King; L J. 34:395-42 (1975).
Sullivan (Carnegie-Melloii Inst. Res.), Toxicology and Applied Pliarma- Source: Not available froni API
cology 32(2):246-66 (May 1975).
Source: Not available from API 26-60086
Petroleum Hydrocarbon Toxicity Studies-8. Animal and Human
26-60083 Response to Vapors of "140"Flash/Aliphat¡e Solvent". Exposure for
Petroleum Hydrocarbon Toxicity Studies-5. [Studies of] Animal and eight hours to 43 ppm caused no ill effects in rats. Similarly, there were
Human Response to Vapors of Mixed Xylenes indicated a relatively no iii effects in cats exposed for six hours to saturated vapor or to
low toxicity and suggested a hygienic standard of 110 ppm. The LbO aerosol. Dogs exposed for eight hours to 33 ppm also showed no ill
was 92 min for rats inhaling 11,000 ppm, which is nearly saturated air. effects. Neither vapor nor aerosol caused respiratory tract irritation in
LC50 for rats in 4-hr inhalation was 6700 ppm. Dogs showed no effect mice. Exposure for six hours per day for 72 days caused no serious
at 530 ppm, lacrimation at 1200 ppn. Cats died within 2 hours on effects in rats or dogs. However. breathing aerosols of 0.5 pm droplets
exposure to 9500 ppm. Exposure for 45 minutes to 15.00 ppm caused no caused three of ten rats to die in the six hours. No erythrocyte fragility
increase in erythrocyte fragility in rats. Respiratory rates were depressed changes were observed in rats' blood after seven hours in approximately
by 50 per cent or more in mice exposed for one minute to 12,000 ppm. saturated vapor. Tests with humans gave an odor threshold of 0.6 ppm
Rats and dogs showed no ill effects in 65 days of six hour-per-day and no serious discomfort. The 140° Flash Aromatic Solvent has an
inhalation of 810 ppm. "Challenge" exposure tests of rats to 6700 ppm A S T M boiling range of 363-402 OF. and contains 61% paraffins. 25%
showed no protective effect of prior exposure to 810 ppm. A six-person monocycloparaffins, and 11% dicycloparaffins. Tables. (Supported by the
panel deiermined the odor threshold to be about 1 ppm. Except for eye American Petroleum Institute)
imtaiion in four of the six people, there were no common signs of IC. P. Carpenter, E. R. Kinkead; D. L. Geary: J. M. King; L J.

69
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and Applied Pharma- Source: Not available from API
îology 34:413-29 (1975).
Source:Not available from API 26-60090
Petroleum Hydrocarbon Toxicity Studies-12. Animal and Human
26-60087 Response i o Vapors of "40" Thinner indicate a hygienic standard of
Peîroleum Hydrocarbon Toxicity Studies--9. Animal and Human 25 ppm for the hydrocarbon, which has an ASTM boiling range of
Response to Vapors of"80 Thinner". Rats showed no ill effects in four 368-447 "Fand contain a b u t 35% paraffins, 35% mono- and dicyclopar-
hours exposure to 810 ppm. The LC50 for rats at four hours was 6200 affins. and about 25% alkylbenzenes. Rats and dogs showed no ill effects
ppm. Dogs showed no ill effects from four-hour inhalation of 480 ppm. in eight-hour breathing of 33-43 ppm vapor or tenday, six-hour-per day
Cats showed central nervous system depression after four-hour inhalation exposure to 31 ppm. There were no lasting effects on rats subjected to
of 5500 ppm but there were no deaths. No change in erythrocytes eight-hour inhalation of an 8.3 mgfi. aerosol. Exposing rats and dogs to
fragility occumd in the blood of rats after 30 minute inhalation of 36 pprn for 65 days had no toxic effects as indicated by hematological
15.000 ppm. Exposure to four hours of 7800 ppm killed i 4 of 16 rats findings, blood chemistry, and weight measurements of liver, kidney, and
within four hours. At loo0 ppm, there was 50% respiratory rate entire bcdy. The d o r threshold in humans was 0.17 ppm. (Supporied by
depression in three of six mice, no effect at 530 ppm. Rats and dogs that the American Petroleum Institute)
inhaled up to 390 ppm for 70 days. six hours per day, showed no C. P. Carpenter. D. L Geary; J. M. King: R. C. Myers; D. J.
significant pathological changes. Pre-exposure to 80 Thinner had no Nachreiner. L J. Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and
effect on the response of rats to six hours of 9700 ppm. Work with Applied Pharmacology 36:457-72 (1976).
human volunteers established an odor threshold at 0.9 ppm and indicated Source: Not available fmm API
that 100 ppm probably would be tolerated by most individuals and is
thus, a reasonable hygienic standard. Tables. (Supported by the American 26-60091
Petroleum institute) Peîroleum Hydrocarbon Toxicity Studies-13. Animal and Human
C. P. Carpenter. E. R. Kinkead; D. L Geary; J. M. King: R. C. Response to Vapors of Toluene Concentrate. A hygienic standard of
Myers; D. J. Nachreiner. L J. Sullivan (Carnegie-Mellon Inst. Res.). 480 ppm was recommended for Toluene Concentrate. which has an
Toxicology and Applied Pharmacology 36:409-25 (1976). ASTM boiling range of 203-231 "F and consists of about 50% toluene,
Source: Not available f r a n API 15% naphthenics. and 35% paraffins. Rats showed no ill effects in
four-hour inhalation of 1700 ppm. Dogs inhaled 760 ppm for six hours
26-60088 without ill effects. Central nervous system depression signs were
Petroleum Hydrocarbon Toxicity Studies..lO. [On the Basis ofJ observed in cats inhaling 7800 ppm for six hours. The LCSO for rats was
Animal and Human Response to Vapors of "50 Thinner". A hygienic 8800 ppm. and the L150 at 45,000 ppm was eleven minutes. Inhaling
standard was suggested at 430 ppm for the thinner. which has an ASTM 2oooO ppm for 45 minutes caused no change in osmotic erythrocyte
boiling range of 208-221 O F and is essentially a 2:i mixture of normal fragility in rats blood. A 50% depression of the respiratory rate was
heptane and toluene. Rats showed no ill effects in four hour exposure to obtained with mice at 8600 ppm. "Challenge" exposure tests on rats
1300 pprn of the solvent. The LC50 for rats was 8300 ppm. Dogs breathing 12,000 ppm for six hours showed that prior acclimation to
showed no ill effects in six hours inhalation at 600 ppm. Centrai nervous Toluene Concentrate decreased moriality. Exposure of rats and dogs to
system effects were observed in cats inhaling 7600 ppm for six hours. 980 pprn of Toluene Concentrate or 65 days, six hours per day at 980
There was no effect on the erythrocyte fragility of rats that had been ppm produced no ill effects as indicated by hematology, clinical
exposed to 25,000 p p n for seven minutes. The WO was 16 minutes at chemistry, micropathology, and body, liver, and kidney weight measure-
24.000 ppm. A 50 per cent respiratory rate depression was observed in ment. The odor threshold for humans was 2.5 ppm. Tables and I5
five of six mice inhaling 11000 ppm. No pathological effects were references. (Supported by the American Petroleum Institute)
observed in rats and beagles that inhaled 50 Thinner in concentration up = C. P. Carpenter. D. L. Geary; J. M. King; R. C. Myers; D. J.
to 600 ppm six hours per day for 65 days, based on blood chemistry, Nachreiner. L J. Sullivan (Carnegie-MeUon inst. Rest.). Toxicology ana!
hematological findings. and body, liver, and kidney weight measure- Applied Pharmacology 36:473-90 (1976).
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

ments. "Challenge" exposure tests on rats at 18.000 ppm for ninety Source: Not available from API
minutes showed no effects of prior exposure to the hydrocarbon. The
odor threshold in humans was 2.5 ppm. Tables and 13 references. 26-60092
(Supported by the American Petroleum Institute) ...
Mutagenicity Evaluation of Benzene Final Report. In a study
C. P. Carpenter, D. L Geary; J. M. King; R. C. Myers; D. J. conducted by Litton Bionetics Inc. for the American Petroleum Institute,
Nachreiner. L J. Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and benzene was evaluated for genetic activity in a battery of genetic assays
Applied Pliarniacology 36:427-442 (1976). employing microbial cells. cultured mammalian cells and rat bone
Source:Not available from API marrow cells (derived from animals treated in vivo). n i e microbial and
cultured mammalian cells were treated under nonactivation and activation
26-60089 conditions (hepatic microsome preparations) so that biologically active
Petroleum Hydrocarbon Toxicity Studies--11. Animal and Human metabolites, if produced, could be detected. This series of tests provided
Response to Vapors of Deodorized Kerosene indicates a hygienic a good cross section of genetic end p i n k including both gene mutations
standard of 14 ppm, ¡.e., saturated air at 25 OC. No toxic effects were and chromosome mutations. The microbial tests and the mouse lympho-
noted in eight-hour inhalation tests with rats, dogs, or cats in air saturated ma assay showed negative results at all dose levels. A dose-related
with deodorized kerosene. There was no upper respiratory tract irritation increase in chromosome aberrations was observed in the subchronic test
of mice on inhaling vapor or an aerosol of 6.9 mgfi. In four days of in rat bone marrow cells. The effects at the higher two dose levels (0.053
six-hour-perday inhalation of 7-9.6 mgfi. aerosols of Deodorized and 0.16 rnl/rat) were significant and indicate that benzene found in the
Kerosene. rats were unaffected except for irritation of the extremities. bone marrow preparations from the benzene-treated rats was chranosome
There were no toxic effects in 65day. six-hour-per-day exposure of rats fragments. 'Ihese probably resulted from chromosorne breakage prior to
and dogs to 14 ppm concentration as indicated by blood chemistry. cell division. Tables and graph.
hematological findings. and body, liver. and kidney weight. The odor API Medical Research Publication (July 1977) (134 p.).
threshold in humans was 0.09 ppm. The kerosene has an ASTM boiling Source: API Library
range of 406-522 O F and contains 55.2% paraffins and 40.9% naphthenes
by weight. Tables and 13 references. (Supported by the American 26-60093
Petroleum Institute) A Health Survey of Petroleum Asphalt Workers. A survey was
C. P. Carpenter. E. R. Kinkead; D. L Geary: J. M. King; R. C. conducted by the American Petroleum Institute of the health of 462
Myers; D. J. Nachreiner. L J. Sullivan (Camepie-Mellon Inst. Res.), asphalt workers in 25 oil refuienes. and of 379 controls. Each worker
Toxicology and Applied Pliarniacology 36:443-56 (i 976). had been engaged in asphalt work for at least five years, the average

70

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBLm4b34 9 5 0732290 0550030 BTL M

being 15.1 yr. A physical examination. including a detailed medical and involving daninant lethality tests in mice and rats showed no pattern of
occupational history. was done on each subject. No significant differenc- decreased pregnancy or increased embryo loss, and thus no mutagenicity.
es in health were found between the two groups. Additional information VM and P Naphtha, Stoddard Solvent, Rubber Solvent. Mixed Xylenes,
concerning the health of their workers was obtained from paving 60 Solvent, 70 Solvent, 140 Aliphatic Solvent, 80 Thinner, 50 Thinner,
companies, roofing manufacturers, and interstate truck operators who Deodorized Kerosene, High Aromatic Solvent, 40 'lñinner, and Toluene
drive over asphalt highways. The health of these groups also gave no Concentrate were injected into male Swiss-Webster white mice and
evidence that petroleum asphalt constituted a health hazard. Table and 11 Long-Evans rats. Females that mated with the injected males were
references. subsequently examined for deciduomata (early deaths), late deaths and
C. N. Baylor (Texaco Inc./Cornell Univ. Med. Sch. Bellevue Hosp.): total implants following removal of the uterus. Com oil and water were
N. K. Weaver (Humble Oil & Ref. CoJïulane Univ./Univ. Tex.), used as negative controls and tnethylenephosphoramide as positive
Archives of Environmenial Health 17(2):210-214 (Aug. 1968). control. Most of the materials tested showed little deviation from the
Source: Not available from APl results obtained with the negative controls. Where deviations did occur.
they were apparently random, unlike the consistent, reproducible
26-6009.1 differences in the positive control groups. Tables.
Trace Metais in Urban Aerosols. A study was conducted by the New MI Medical Research Publicaiion (1973) (28 p.).
York University Medical Center for the American Petroleum Institute and Source: API Library
the Edison Electric Institute to characterize suspended and settled dusts
in the New York City. Samples were analyzed for Pb. V, Cu, Cd, Cr, Fe,
Mm, Ni, and Zn. Pb, V, Cu. Na, and K were use as tracers for dust 26-60099
associated with automotive sources. oil burning, incineration, and natural Rat Bone Marrow Cytogenetic Analysis [for] Unleaded Gaso-
sources (sea salt and soil). 'Ihe fractions of the total suspended particu- ..
line .Final Report. Maie rats injected intraperitoneally with unleaded
lates (TSP) associated with these sources in 1973-74 were: automotive. gasoline at low, intermediate, and high acute and subchronic dose levels
30%: oil burning, 12% incineration, 5%: natural, 18%. and unassigned. were injected with colchicine 2 hr prior to sacrificing to arrest diving
35%. The composition of dustfall samples was closely related to the cells in the metaphase, and bone marrow cells from the femurs and tibias
composition of TSP. Current dustfall levels appear to be - 100 times were subsequently examined for chromosomal aberrations. Acute dosages
lower than those repotted in the 1930's. Analysis of human tissues at were 0.15 mi of a 1 5 dilution of the gasoline in acetone as the low dose;
autopsy produced no indication of pathological lesions related to 0.1 mi of undiluted gasoline as intermediate; and 0.3 ml as high. Seu of
concentrations of heavy metals. An exponential lung model was used. test animals and controls were killed 6.24, and 48 hr after dosing. in the
along with measured values of Pb. Cr, and Ni in the New York City air subchronic studies. the rats were dosed once each day for five days, and
and in the lungs and lymph nodes of New York City residents. to show killed 6 hr after the final dose. The dose levels were 0.06 ml of a 1 5
-
that the biological half-times in the lung are: 50 days for Pb; 800 - dilution of the gasoline in acetone; 0.19 ml of the same solution; and
days for Ni; and -
1100 days for Cr. Tables, graphs, flow diagrams, 0.13 ml of undiluted gasoline. The occurrence of chromosomal aberra-
maps, diagrams, and 203 references. tions was within the noma1 background range, the highest being 1.3%
M. Eisenbud T. J. Kneip; D. Bernstein; M. T. Kleinman; M. at the 48 hr acute high dose.
Lipprnan: R. Riddick (N.Y.Univ. Med. Cent.), API Medical Research rn API Medical Research Publicarion (Nov. 1977) (110 p.).
Publicaiion EA-7601 (lO/iOflS) (440 p.). Source: API Library
Source: API Library

26-60095 26-60100
Facts and Opinioiis on the Role of Sulfur Dioxide in Causing Injury Further Studies of the Mutagenicity of Hydrocarbon Fractions [by]
[to Human Health]. A review covers acute effects; chronic effects; Utilizing Somatic Mutations in Rats. n i e cytogenetic study canied out
moiiality; morbidity; the effects of sulfur dioxide pollution on mortality: by Hines Inc. for the American Petroleum Institute. involving measure-
the effects of sulfur dioxide pollution on morbidity, including upper ment of chromosomal aberrations in the bone marrow and blood of rats
respiratory diseases, pneumonia, and bronchitis; and the absence of exposed to three petroleum fractions, confirmed the previously observed
evidence that sulfur dioxide is a factor in health damage at the levels mutagenicity of 60 Solvent and Rubber Solvent, and showed that a
found in ambient air. 81 references. (Supported by the American High-Aromatic Solvent was a less active mutagen than the other two
Petroleum Institute). solvents. The solvents also caused a deep depression revealed by
Mario C. Battigelli. API Air Qualiry Monograph 69-10 (Feb. 1969) temporary weight losses of the rats. In the tests on a single group of 50
(20 p.). male Long-Evans rats, the three solvents diluted in com oil were injected
Source: API Library intraperitoneally in three doses spaced three days apart, and the chrano-
some analyses were made on blood and bone marrow specimens at 1.7,
26400% and 30 days after the treatment. Negative control rats received three corn
The Chronic Toxicity of Lead. In an experimental study conducted by oivwater injections on the same schedule. and positive control animals
Hazleton Laboratories lnc. for the American Petroleurn Institute to received a single dose of triethylenemelamine at the time of the third
evaluate the effects of the ingestion of small amounts of lead acetate by injections for the other two groups. Tables.
laboratory animals (rats, dogs, monkeys. and rabbits) over a substantial API Medical Research Publicaiion (1978) (51 p.).
pari of their lifespan, 10 ppm (as lead) produced no detectable effects Source: API Library
after 22 mo; thus, 10 ppm lead in the diet is a "no-effect'' level. Minimal
effects were observed in some animals at 50 ppii, and some histologic 26-60102
changes (principally in the kidney), but no functional changes, were Mutagenicity Evaluation of Diesel Fuel. In tests canied out for the
detected in rats fed 100 ppm and 1000 ppm. These amounts of lead American Petroleum Institute. an unspecified diesel fuel was not
administered to the animais are far above the usual intake by man. In mutagenic for Ames Salmonella tester strains in plate tests or in the
addition to the common chronic toxicity tests. the program included Mouse Lymphoma Assay that measures forward mutation at the
studies on reproduction. teratology, behavior, carcinogenicity, and thymidine kinase locus. but i t was clastogenic in the Rat Bone M a m w
metabolism, as weil as special enzyme and electron microscope studies. Cytogenic analysis. and thus should be considered a clastogen for
J. Clifford Jessup. API Medical Research Report EA-7102 (Apr. 1971) animals. T h e predominant aberration was nonheritable chromosomal
(9 PJ. fragmentation: few arrangement types of aberration were observed.
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

Source: API Library Extensive tabulations detail the test conditions and specific results
obtained.
26-60098 API Medical Research Publicaiion (Jan. 1978) (148 p.).
Mutrgmirity Study of Thirteen Petroleum Fractions. A study Source: API Library

71

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I PUBL*4634 95 0732290 0550031 738

26-60103 exposures to CO. Thus. the CFK equation is a good theoretical model for
Estiniation of the Mutagenicity of Hydrocarbon Fractions Utilizing the uptake and excretion of CO. A rational, efficient procedure for
the Bacterial Assay Procedure wiIh Mammalian T i s u e Metabolic solving the equation by trial and error is outlined; a graph relating COHb
Activation. API Projecl PS-4 #6. Vamish makers' and painters' saturation to exposure duration and concentration, prepared by solving
naphtha, Stoddard solvent, rubber solvent. 140 flash aliphatic solvent, 60 the CFK equation, is presented; and the effects of several variables on
and 70 solvents, 50 and 80 thinners, mixed xylenes, deodorized kerosine, the rate of CO uptake and equilibrium COHb levels are discussed.
and high-solvency naphtha were tested for mutagenicity by the Ames Tables, graphs, and 18 references.
in-vitro test, which utilizes two specially sensitive mutant strains of 8 J. E. Peterson; R. D.Stewart (Med. Coll. Wis.), M I Medical Research
Salmonella fyphimurium baaeria; the tests were carried out in the Publicarion #4189 (June 1973) (46 p.).
presence and absence of a microsomal liver extract from male rats. For Source:API Library
all the solvents tested. the number of colonies reverting (mutating) to
histidine independence was comparable with that in the negative control 26-60107
tests, run in the presence of dimethyl sulfoxide, indicating no mutagenic Fluorosis of Livestock. A review covers the factors affecting the
activity; several of the solvents had to be diluted 1:lO with dimethyl occurrence of fluorosis, including species other than caüie; diagnosing
sulfoxide due to their toxicity to the bacteria. Tables. fluorosis, including the clinical aspects. acute fluorine toxicosis. and
8 API Medical Research Report (1978)(8 p.). chronic fluorosis; the effects of ingesting up to 93 p p n of fluorine for up
Source: API Library to 7.5 yr on the general condition of cattle, including the hair and skin,
hoofs, soft tissues. blood, placental transfer, reproduction, and milk
26-60101 production; and methods of alleviating fluorine toxicity (e.g.. with
A Morbidity Study of Petroleum Refinery Workers at six refineries chemical food additives that act as inhibitors). Graphs, tables. photo-
in 1973 was canied out by Tabershaw/Cooper Associates, Inc. by graphs, and 30 references. (Supported by the American Petroleum
examination of medical absenteeism records. with the overall results for Institute)
all refineries comcied for the difference in worker age distribution m J. L Shupe (Utah State Univ.). API Air Quality Monograph 69-4
between the different refineries. The six refineries employed a total of (Feb. 1969) (29 p.).
4777 men and had a total of 209 absences&r/100 men. of which 163.2 Source: API Library
absences were < 5 days and 21.2 days of absences 5 days. The average
frequency rate (ratio of nuniber of illnesses to nuniber of workers x 100) 26-60108
was 45.8 for ail refineries; average frequency rates by illness were 15.3 Photochemical Smog. A review covers the nitrogen oxides, including
for respiratory and 4.1 for digestive ailments. 4.1 for fractures, sprains, atmospheric analyses, automatic monitoring in Los Angeles and Menlo
dislocations, etc., 0.5 for malignant neoplasms and lymphomas, and 0.4 Park, Calif.. reactions with olefins, measuring total nitrogen compounds,
for benign and unspecified neoplasms. Average severity rates (ratio of and the phytotoxicity of nitrogen dioxide; oxidants, including the
days lost to number of workers x 100) were 970.8 total for all refineries, determination of ozone and oxidants in the atmosphere, damage to plants,
149.4 for circulatory. 141.9 for respiratory, and 104.4 for digestive and adverse effects on citrus trees; organic p o l l ~ t a n t (especially
~
ailments, and 17.4 for malignant neoplasms. Racve (white vs. non-white) polynuclear aromatic hydrocarbons), including detectors, urban pollution,
did nol appear to affect occurrence or duration of illnesses. Methods of Los Angeles smog, and eye irritation; and various national and state air
obtaining the data and its validity are discussed. (Supported by the quality standards. Tables and 91 references. (Supported by the American
American Petroleum Institute) Petroleum Institute)
m API Medical Research Piiblicaiion (4/28/75)(34p.). a M. D. Thomas (Am. Public Health Assoc.). API Air Quality Mono-
Source: API Library graph 69-6 (Feb. 1969) (40 p.).
Source: API Library
26-60105
T h e Effects of Chronic Exposure to Low Levels of Carbon Monoxide
on the Cardiovascular System of Dogs-l. Exposure to 100 ppm 26-60110
Carbon Monoxide. A study was undertaken at Jefferson Medical Barium. A survey prepared for the American Petroleum Institute covers
College with support from the Coordinating Research Council Inc. to the geochemistry of barium in mineral deposits, in water, and in air. the
obtain quantitative correlations between chronic exposure to low-level presence of barium in marine organisms, in land plants and animals, and
carbon monoxide (100 ppni CO, 23 hr/day for 14 weeks) and the in mammals, especially man; human exposures to barium., with daia on
physiologic parameters of the cardiovascular system and blood of normal geographic variation. barium in the lungs, and barium accumulation in
dogs and of dogs with induced myocardial infraction and to determine human tissues with age; atomic structure. biochemical functions, and
the relationships between carbon monoxide exposure and the pathology pharmacology of barium; barium metabolism; the toxicity of barium salts
of various body organs (heart. lungs, liver, kidneys. adrenals, and brain). especially those used as pesticides and as smoke suppressants in diesel
No obvious signs were noted which could be interpreted as CO-induced. fuel; industrial exposures io barium: and air quality standards for barium.
Throughout their exposure to CO. the animals were in clinically good Tables and 20 references.
health, and there were no characteristic alterations of the serum enzymes 8 H. A. Schroeder (Dartmouth Med. Sch.), API Air Quoliry Monograph
or the electrocardiogram that could be aitributed to CO exposure. 70-12(Oct. 1970) (25 p.).
Hematologic parameters did not appear to change significantly during Source: API Library
exposure. Carboxyhemoglobin averaged 144 at 100 pprn CO exposure.
Diagrams, tables, graphs, photographs. and 48 references.
8 API Medical Research Pirblicaiion #4096 (Oct. 1970) (81 p.). 26.60111
Source: API Library Vanadiuni. A review compiled for the American Petroleum Institute
covers the geochemistry of vanadium and niobium in the geosphere, in
26-60106 the atmosphere, and in the hydrosphere; vanadium and niobium in the
Predicting T h e Carboxyhemoglobin [(COHb)] Levels Resulting from biosphere; human exposures to vanadium and niobium, principally in
Carbon Monoxide [(CO)] Exposures. Data from 22 humans exposed food. and their accumulation with age; atomic structure, biochemical
to 50-200 pprn CO for 0.33-5.25hr were fitted to the Coburn. Forster. fundions, and pharmacology: vanadium metabolism; toxicity of
Kane (CFK) equation for predicting COHb levels as a funaion of vanadium; the possibility that vanadium has a biological role in mammals
experiment dumiion and CO concentration, exercise levei (sedentary to essential for optimum function; and the tolerable limiu of vanadium in
300 kp-mhnin). and sex. The equation satisfactorily prediaed the COHb air. Tables and 65 references.
levels for both men and women at steady concentration levels of 50-200 8 H. A. Schroeder (Dartmouth Med. Sch.), API Air Quoliry Monograph
ppm. even though the female subjects absorbed CO more rapidly than the 70-13(Oct. 1970) (32 p.).
male subjects; it also accurately summed the results of disconiinuous Source: API Library

72
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 95 0732290 0550032 674

26-60112 (27 P.).


Nickel. A review prepared for the American Petroleum Institute covers Source: API Library
the geochemistry of nickel; nickel in plants, animals, and man and its
geographic variation; human exposures to nickel; atomic structure. 26-60117
biochemistry and pharmacology of nickel; nickel metabolism; nickel Experiments in Human Work Capabilities under Pressure, Now
toxicity, including demiatitis, respiratory diseases. and cancer; industrial Being Conducted at the Institute for Environmental Medicine,
exposures; and proposed air quality standards. Tables and 39 references. University of Pennsylvania, indicate that diving operations at depths
8 H. A. Schmder (Dartmouth Med. Sch.), API Air Qiroíiry Monograph well below 2000 ft of sea water are feasible with properly chosen
70-14 (Oct. 1970) (24 p.). breathing mixtures. In experiments in the pressure chamber complex at
Source: APl Library the University of Pennsylvania four men accomplished ali tasks
satisfactorily while breathing mixtures containing helium at pressures
26-60113 equivalent to 1200 ft of sea water and neon at 700 and 900 ft (equivalent
Chromium. A review prepared for the American Petroleum Institute to helium at 2000 and 4000 fi). With neon at 1200 ft, the subjects
covers the geochemistry of chromium, molybdenum, and tungsten; -
stopped exercising after 27 min of a 30 min schedule. When breathing
chromium and molybdenum in the air, including the sources and particle nitrogen at the equivalent of air at 500 ft of sea water depth, the subjects
sizes; chromium and molybdenum in living things, including plants, suffered impaired coordination and mental functioning as weii as
animals. and humans, and changes with age; chromium in human lungs; p u h o n a v stress. The experimental results have permitted plotting curves
human exposures to chromium and molybdenum in food; the atomic of pulmonary resistance and peak pulmonary ventilatory flow vs. for
structure and biological functions of chromium; chromium metabolism; nitrogen. neon, and helium. These curves should permit prescribing
pharmacology and toxicity of chroniium. especially the hexavalent form; optimal mixtures of inert gases for breathing under pressure. Problems
industrial exposures of workers to chromium and the concomitant health encountered in the experiment were mainly skin itching and vestibular
effects: and air quality standards for chromium. Tables and 38 references. function derangement. No evidence of hypoxia was found in the
8 H. A. Schroeder (Dartmouth Med. Sch.), API Air Qituiity Monogruph experiment, in which oxygen concentration was always exactly equiva-
70-15 (Oct. 1970) (28 p.). lent to that of sea-level air. Decompression was smooth and without
Source: API Library incident. At the highest pressure. 1200 fi. three of the four subjects
developed vertigo and nausea indicative of vestibular or acoustic nerve
26.60115 disease, probably due to a viral infection transmitted from one subject to
Manganese. A review prepared for the American Petroleum Institute another. The symptoms cleared spontaneously while the subjects
covers the geochemistry of manganese: manganese in plants and animals; remained under high pressure. nie experiments demonstrated that neither
human exposure to manganese in air, water, and food; atomic structure hydrostatic pressure nor a helium breathing mixture was physiologically
and biochemical functions of manganese; manganese and mammalian or mentally limiting. Changes in pulmonary function generated by sharp
metabolism. homeostasis and accumulation from the environment; rises in gas density were not severely limiting when the subject
pharmacology and toxicology: and air quality standards for manganese. performed moderate work in a neon breathing atmosphere equivalent to
Tables and 44 references. helium at 5000 fi of sea water.
H. A. Schroeder (Dartmouth Med. Sch.). API Air Qiroiiry Monograph W. B. Wright (Univ. Pa. Insi. Environ. Med.), APl Medical Research
70-17 (July 1971) (34 p.). Report EA-7104. pp. 43-53 (1972).
Source: AP1 Library Source: API Library

26-60115 26-60118
Cadmium, Zinc, and Mercury. A review prepared for the American Oils Mist: [An] Evaluation of [Workplace] Sampling Procedures.
Petroleum Institute covers the geochemistry of zinc. cadmium. and Sampling procedures sponsored by the American Peiroleum Institute
mercury; sources and effects of zinc. cadmium. and mercury in the air, Subcommittee on Industrial Hygiene showed that collection on Whatman
their effects on plants, marine organisms, mammals, especially man. and #41 paper, BM-2133, or on a glass fiber filter in a filter holder is
their concentrations in man as a function of age: cadmium and zinc in suitable. with appropriate modifications in the presence of metal chips
human lungs; human exposures to zinc. cadmium, and mercury; their and dust, for oil mists without vapor. a better sample is obtained if the
atomic structures; their role in human metabolism; human requirements employee wears a personal sampler; a two-stage sampler will separate
for zinc; the pharmacology and toxicity of all three metals; zinc, respirable from nonrespirable mist; electrostatic precipitation is a very
cadmium, and chronic diseases. and the air pollution aspects of zinc, good method, a silica gel. activated charcoal, or impinger method is
cadmium. and mercury, including tolerable levels. Tables. graphs, and 70 suitable for determining mist plus vapor; and that the threshold limit
references. value of 5 mg/cu m does not distinguish between respirable and
H. A. Schroeder (Dartmouth Med. Sch.). API Air Qiculiiy Monograph nonrespirable mists. 12 references.
7 0 4 1 (July 1971) (40 p.). 8 A f I Med. Res. EA-7201 (May 1972) (5 p.).
Source: API Library Source: API Library

26-60116 26-60119
Microparticulate Sulfates: Effects on Human Health. A review Guidelines on Noise include definition of measurement units; criteria for
conducted by the American Petroleum Institute show that sulfuric acid allowable noise levels for preventing hearing loss, based on OSHA
mist appears to be more irritating than sulfur dioxide for equivalent standards, local ordinances, ambient noise levels in the community, and
sulfur concentrations. The irritating quality of the sulfates, for equivalent prevention of interference with speech; instruments for measuring sound
sulfur concentrations, varies depending on their particle size. composi- levels, including portable meters to determine the fmquency distribution.
tion. and water solubility. An interaction between sulfur dioxide and niicrophones, acoustic calibrators, vibration pickups and personnel
ozone or hydrogen peroxide exists and probably results in the formation dosimeters; errors due to temperature, humidity. wind, and electmmagnet-
of sulfuric acid. From the epidemiologic studies. it has been difficult to ic fields; choice of instruments based on the type of noise, ¡.e., steady,
separate the effects of sulfur dioxide. sulfates. and particulates and their broadband, fluctuating, intermittent. or impulsive; spot measurements and
interactions. Some, but not all. of the studies showed that the sulfate determination of isopleths: data recording; basic acoustical concepts,
component is the major irritative component. Since not all sulfates are including sound pressure. power, directivity. and absorption and
equally irritating, if a sulfate level is proposed, it should be related to a transmission loss; sound attenuation through dense woods, hills,
specific sulfate. The identification of the sulfate levels that are accept- buildings, etc.; estimating community noise levels for new plants;
able, or the levels above which interference with health occurs, are not predicting in-plant noise levels from multiple sources of steady noise;
clearly defined. Table and 58 references. noise reduction through proper plant layout and equipment specificaiion:
m B. G. Fems (Harv. Univ.). API Air Quaiiry Monogruph 75-24 (1975) general noise reduction, including absorbent materiais for enclosures,

73
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L E 4 6 3 4 95 0 7 3 2 2 9 0 0550033 500 W

mufflers and in-line silencers for piping noise, acoustical lagging, and suggested hygienic standard for inhalation of Varnish Makers and
damping of vibrations; and noise control techniques for furnaces, electric Painters Naphtha (VM&P naphtha) for man is 430 w m . Inhalation of
motors, control valves, piping, heat exchanger. fans in cooling towers, saturated vapor for more than a few minutes constitutes a hazard of lúe.
compressors, gears, flares. and gas turbines. Suppliers of noise- and Rats tolerated saturated vapor at man temperature for 7.5 min. The
vibration-control systems and materials are tabulated. Graphs, diagrams. single 4-hr inhalation LC50 for rats was 3400 ppm, and the highest
tables, and 120 references. concentration producing no discomfort was 940 ppm. Rats that survived
API Medical Research Report EA-7301 (1973) (1 11 p.). the 65day inhalation schedule for 1200, 600, and 280 pprn were
Source: API Library challenged with 5800 ppm for 6 hr. All treated rats were more resistant
in terns of mortality ihan were controls. Cats responded with signs
26-60120 indicative io severe central nervous sysiem effect when subjected to 4100
A Mwîality Study of Petroleuni Refinery Workers. A study of all the ppm for 4 hr but all cats survived. There were no dosage-related
hourly, nonclerical, male workers employed for at least one year between differences between the controls and rats and beagles that inhaled 2.8
1/1/62 and 12ß1/7 1 in 17 U.S.refineries, chosen to give a representative mg/l. or 1.3 mg/l. for 6 hr daily, 5 days each week for 13 wk. ï h e odor
sample of size, geographic a m , and ownership, was carried out under threshold for VM&P naphtha in sniff tests was 0.86 w m . During a
API sponsorship by tracing 94% of the 20,163 workers involved and 15-min inhalation period, four of seven subjects had upper respiratory
obtaining the death certificates for i 145 of the i 165 deceased. Most of tract initation at 880 ppm. (Supported by the American Petroleum
the men had been employed for at least ten years. T h e Standardized Institute)
Mortality Ratio (SMR) was 69.1, compared with the general male U.S. D. L. Geary; E. R. Kinkeak C. P. Carpenter; J. M. King; L. J.
SMR of 100. Mortality from cardiovascular-renal diseases, digestive Sullivan (Carnegie-Melìon Inst. Res.), Toxicology and Applied Pharma-
cancer, and stomach or duodenal ulcers were higher for men with the cology 32(2):263-81 (May 1975).
least exposure to hydrocarbons. Mortality from respiratory and genital Source: Not available from API
cancer increased with increasing exposure. Mortality from lymphomas
was greater than expected, though not statistically significant. Extensive 26-60124
data are tabulated. Petroleum Hydrocarbon Toxicity Studies-3. Animal and Human Re-
API Medical Research Report EA-7402 (9/15/14) (47 p.). sponse to Vapors of Stoddard Solvent. The suggested hygienic standard
Source: API Library for inhalation of Stoddard Solvent for man is 200 ppm. Inhalation of
1400 ppm (substantial saturation at 25 OC) caused the death of 1 of 15
26-60121 rats aí the termination of 8 hr. Beagle dogs had clonic spasms in 5 hr and
Cytologic and Cytogenetic Effecîs of Benzene [on Human Health]. A cats died between 2.5 and 7.5 hr. There were no differences between the
review of the effects of benzene on the individual cell as found in controls and groups of beagle dogs that inhaled 330 ppm, 190 ppm and
published experimental studies on various animals, chromosome studies 84 ppm 6 hr daily, 5 days/wk for 13 wk. However, rats exposed to 330
in exposed humans, and studies on industrially exposed workers indicates ppm for 65 days exhibited slight pathological changes in the kidney. The
that the last group furnishes the most reliable and consistent data with odor threshold in a sniff test is below 0.9 ppm. In a 1 5 4 1 1 inhalation
control group comparisons and better documented exposure conditions. period. only slight eye imtation was reponed by one of six persons at
However, the reported effects are both variable and contradictory. and it 150 ppm. (Supported by the Amencan Petroleum Institute)
is impossible to distinguish carcinogenic from toxic effects. Clarification E. R. Kinkead: D. L. Geary; C. P. Carpenter, J. M. King: L J.
of the mode of action of benzene on the cell nucleus will require Sullivan (Carnegie-Mellon Inst. Res.), Toxicology and Applied P h a m -
extensive and well-designed aninial and in-vitro studies. This work was cology 32(2):282-97 (May 1975).
done under contract of the American Petroleum Institute with the New Source: Not available from API
York University of Environmental Medicine.
m S.R. Wolman (N.Y. Univ.). Jorvnal of Toxicology and Environmental 26-60125
Health Supplement 2:63-68 (1977). Petroleum Hydrocarbon Toxicity Studies-4. Animal and Human
Source: Not available from API Response to Vapors of Rubber Solvent. ï h e suggested hygienic
standard for inhalation of Rubber Solvent for man is 430 ppm. ï h e LC50
26-60122 for rats by 4 hr inhalation is 15.000 ppm. A conceniration 2800 ppm
Skin Tumorigenesis in Mice by Petroleum Asphalts and Coal T a r caused no discornfort in rats in 4 hr while for dogs, the corresponding
Pitches of Known Polynuclear Aromatic Hydrocarbon Content. In concentration was 1500 ppm. Cats exhibited centrai nervous system
studies patily supported by the American Petroleum Institute and p a d y depression after a 4-hr inhalation of 12,000 p p n but survived. At the
by the National Cancer Institute, benzene solutions of eight petroleum highest concentration obtainable, 45,000 ppm. the LC50 for rats was 4.3
asphalts and two coal-tar pitches of known polynuclear aromatic min. Rais and dogs inhaled measured concentrations of up to 2000 ppm
hydrocarbon (T'AH) content were applied topically to Swiss mice. for 6 hr/day, 5 dayslwk for 13 wk. The rats tolerated the highest level.
Epidermal carcinomas and papillomas were observed in over 90% of In the dogs, the dosage related granulation nodules found in the lungs
coal-tar pitch treated animais, ¡.e.. there were 53 tumor-bearing animals may have been somewhat exacerbated by the solvent vapor, but there
out of 58 autopsied. Only one carcinoma and five papillomatous growths was no similar lung pathology in rats that inhaled the same vapor. The
were observed in 218 mice treated with asphalts. T h e PAH content of the odor of the solvent is detectable at 10 ppm. (Supported by the American
coal tar pitches were several orders of magnitude greater than that of the Petroleum Institute)
asphalts examined. For example, 10,000 ppm benzolalpyrene was found D D. L Geary; L. J. Sullivan; C. P. Carpenter (Carnegie-Melion Inst.
in the coal-tarpiiches. An exceptionally high value of 27 ppm was found Res.), Toxicology and Applied Pliormacology 33526-28 (1975).
in one of the asphalts, whereas the other seven had levels of 0.1-2.5 ppm. Source: Not available from API
However. because of the low tumor incidence in the asphalt-treated mice,
no conclusions could be drawn as to a possible relationship between the 27.00325
PAH content of the asphalts and their tumorigenic properties. Spectrum, In-Vitro and In-Vivo Mutagenicity Studies. New Oil Composite
tables, photomicrographs, and 14 references. [Motor Oil]. Final Report. "New Oil Composite'' (motor oil) showed no
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

L. Wallcave; H. Garcia; S. R. Wolnian; R. Feldnian; W. Lyinsky; P. mutagenic potential in the Ames test. the mouse lymphoma assay, or the
Shubik (Univ. Neb. Coll. Med.). Toxicology and Applied Pharmacology in-vivo bone marrow test. n i e Ames test used selected strains of
18(1):41-52 (Jan. 1971). Salmonella typliimurium bacteria. In the lymphoma test, mouse lympho-
Source: Not available from API ma cells were exposed to the oil with and without metabolic activation.
The in-vivo test measured the extent of abnormality in the chromosomes
26-60123 of the bone marrow cells of rats. Photomicrographs and tables.
Petroleum hydrocarbon Toxicity Studies--2. Animal and Human API Medical Research Pitblicarion (8/17/79) (71 p.).
Response to Vapors of Varnish Makers and Painters Naphtha. The Source: API Library

74

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 9.5 I0732290 0550034 4 4 7 I

27-30051 continuously inhaled air containing the pollutants for 104 weeks.
In-Vitro and In-Vivo Mutagenicity Studies. Jet Fuel A. Final Report. Combining calcium sulfate with nitrogen dioxide or with sulfur dioxide
Although Jet Fuel A showed no mutagenicity in the Ames test, it was did not cause a change in effect. Effects on the monkeys were evaluated
mutagenic in the mouse lymphonia assay and in the in-vivo bone marrow from lung function measurements and blood chemistry tests. Maximum
test. n i e Ames test used selected strains of Salmonella ryphimurium pollutant concentrations were 6.78 ppm nitrogen dioxide, 9.7 ppm sulfur
bacteria. In the lymphoma test. mouse lymphoma cells were exposed to dioxide. 66 ppm carbon dioxide, 0.5 mg/cu m lead chlorobranide, and
Jet Fuel A with and without metabolic activation. n i e in-vivo test 9 mgku m calcium suifate. Tables and 19 references. (supported by API)
involved determining the extent of abnormality in the chromosomes of W. M. Busey (Exp. Pathol. Lab. Inc.) A. A. Krumm (Hazleton Lab.
the bone marrow cells of rats. Photomicrographs and tables. inc.), API Medical Research Publication (23 p.).
API Medical Research Publicarion (811315'9) (79 p.). Source: API Library
Source: API Library
27-30705
27-301.10 Carboxyhemoglobin Trend in St. Louis Blood Donors, 1971-1975.
In-Vitro and In-Vivo Mutagenicity Studies. No. 2 Home Heating Oil. CRC-APRAC Project No. CAPM-8-68. n i e median carboxyhemoglo-
Final Report. No. 2 Home Heating Oil showed no mutagenic activity in bin in the blood of 771 nonsmokers in Mardi 1975 was 1.496, unchanged
the Ames test, the mouse lymphoma assay, and the in-vivo bone marrow from Mardi 1971. although estimated carbon monoxide emission from
test. n i e Ames test used selected strains of Salmonella ryphiniurium automobiles had decreased 10%. Carboxyhemoglobin levels were down
bacteria. In the lymphoma test, niouse lymphoma cells were exposed to 0.1% in downtown Si. Louis and 0.2% in the semiurban region,
the oil with and without metabolic activation. The in-vivo test measured compared with 1971. but up 0.2% from 1.3 to 1.5% in the suburban-niral
the extent of abnormality in the chromosomes of the bone marrow cells area, the region of lowest vehicle density. The latter results suggest that
of rats. Photomicrographs and tables. sources other than vehicle exhaust are the dominant factor in prcducing
D API Medical Reseorch Pitblication (7f24f79) (73 p.). carboxyhemoglobin levels above 1.5%. Map, graphs, tables, and 18
Source: API Library references. (supported by Coord. Res. Counc. Inc.)
R. D.Stewart (Med.Coll.Wis./Milw.Co.Med.Cplx; P. E. Newton; A.
27-30183 Wu; J. H. Kalbfleisch; T. A. Stewart (Med. Coll. Wis./Milw. County
Inhalatiodferatology Study in Rats. Fuel Oil. Final Report. Pregnant Med. Complex), A P I Medical Research Piddicaiion (Oct. 1978) (21 p.).
female rats exposed to atmospheres containing 86.9 or 408.8 pprn of fuel Source: API Library
oil showed no evidence of adverse effects, no variation in fetal sex ratio,
and no embryo toxicity or inhibition of fetal growth. Exposure was 6 27-30765
hr/day on days 6-15 of gestation. The test material was a 5 0 5 0 mixture A Twelve-Week Inhalation Toxicity Study of Benzene on Seven
of virgin and cracked gas oil with a boiling range of 437-610 OF. Tables. Species of Animals. Final Report. n i e mouse was the most sensitive
(supported by API) species in tesis involving exposure of all the animals tested to 361-388
API Medical Research Pirblica~ion(Sept. 1979) (29 p.). ppm benzene for 6 hr/day, 5 daydweek for 12 weeks. The mice showed
Source: API Library blood platelet counts that decreased as exposure continued, but this
effect, and ocular distress observed overihe last eight weeks of exposure,
27-30484 were both reversed during a four-week recovery period allowed for some
Inhalationfïeratology Study in Rats. VM and P Naphtha. Final of the mice. Guinea pigs, some of which were held for postexposure
Report. Pregnant female rats exposed to atniospheres containing 104.8 recovery and an additional exposure to benzene, showed no ill effects.
or 391.1 ppm of VM and P naphtha showed no evidence of adverse except for a weight loss which followed an exposure during week 37 and
effects. no variation in fetal sex ratio. and no embryo toxicity or was subsequently reversed. Physical observations on the guinea pigs and
inhibition of fetal growth. Exposure was 6 hdday during the 6th-15th on rats. rabbits, cats, dogs. and monkeys revealed no signs of treatment-
days of gestation. The test material contained 55% paraffins. 33% related effects. Hematology measurements and differential bone marrow
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

cycloparaffins. and 12% alkylbenzenes. The boiling range was 244-304 counts on rabbits, cats. dogs, and monkeys were unremarkable, and some
"F. Tables. (supported by API) variations in the results for rais and guinea pigs did not seem to be
API Medical Research Publication (Sept. 1979) (30 p.). treatment related. Graph and tables.
Source: API Library API Medical Research Publicarion (llR6/79) (122 p.).
Source: API Library
27-30700
Studies on the Evaluation of Problems Associated with the Measure- 27-30839
ment of Low Concentrations of Carboxyhemoglobin. CRC-APRAC Effects of Sulphate Aerosols upon Human Cardiopulmonary
Project No. CAPM-26-75. Using a modified extraction chamber has Function. CRC APRAC Project CAPM-27-75. Human subjects
made gas chromatography with a thermal conductivity detector a exposed to ammonium sulfate at levels simulating the worst case
practical method for determining low carboxyhemoglobin concentrations atmosphere in the Los Angeles basin did not suffer any adverse
in blood. Samples as small as 0.05 ml containing < 1% carboxyhemoglo- short-term health effects. The tests involved i6 normal, allergic, or
bin are satisfactorily analyzed. The spearophotomeiric procedure using asthmatic subjects who were exposed to an atmosphere containing 100
the CO-oximeter was rapid and easy to p e r f o n but less accurate, pg/cu m of ammonium sulfate aerosol for two or three days, two hours
especially for the analysis of postmorteni blood samples and when per day, at 40 or 85% relative humidity. Effects were determined by a
concentrations were below 3%. Commonly-used anticoagulants and series of pulmonary funaion measurements and clinical observaticas.
preservatives did not inierfere. Exposing samples to air caused significant Prior research is reviewed. Graphs, tables. diagrams. photographs. and 42
carbon monoxide loss, but storage in air-tight syringes under refrigeration references. (supported by Coord. Res. Counc. Inc.)
was satisfactory. Photographs, graphs, and tables. m K. A. Bell; J. D.Hackney (Rancho L o s Amigos Hosp.), API Medical
F.R. Goidbaum (Armed Forces Inst. Pathol.) F.L. Rodkey (U.S.Nav. Research Puòlicarion (5/331/77) (212 p.).
Med. Res. Insi.), A P I Medical Research Publication (30 p.). Source: API Library
Source: API Library
27.30840
27-3070.1 The Influence of Trace Metals in Disperse Aerosols on the Human
Study of Synergistic Effects of Certain Airborne Systems in the Body Burden of Trace Metals. A relationship was found between the
Cynomolgus Monkey. No change in physiological effect on the concentrations of cadmium in cigarette smoke and lead in urban air and
monkeys resulted from conibiiiing any two of the pollutants nitrogen the concentrations of these metals in hunian lungs. An association was
dioxide, s d u r dioxide. carbon monoxide, and lead chlorobromide, as noted between cadmium and occurrence of a respiratory bronchiolitis.
compared with each agent alone. In the experiments. the monkeys Similar pathological effects were associated with copper and zinc. No

75

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
A P I P U B L * 4 6 3 4 75 0732270 0550035 383

lung pathology was associated with lead. The data on lead in the lungs mortality than nonsmokers or ex-smokers when age was taken into
of New York City residents suggest a quasi-threshold concentration for account. The recent smokers showed evidence of larger infarcts than the
lead in air: 1.3-1.4 &CU m. Below this concentration. lead in the lung nonsmokers but their hemodynamic function was relatively good. The
is only slightly higher than the background level from ingestion. A results are consistent with both acute and chronic effects on the
size-selective particle sampler was developed for continuous sampling of myocardium of long-term low-level exposures to carbon monoxide, but
urban air to obtain large samples over periods from hours to weeks. The cannot be related to that factor by itself. Graphs and tables. (supported
average concentrations of iron, copper. manganese. zinc. cadmium, in pan by Coord. Res. Counc. Inc.)
chromium, lead, and nickel in human tissues were determined by E. P. Radford M. L. Weisfeldt (Johns Hopkins Univ), API Medical
measurements on lungs, lymph nodes. liver, kidney, blood, bone. and Research Publication (Aug. 1975) (22 p.).
trachea. Graphs, tables, diagrams, and 200 references. (supported by API) Source: API Library
D. M. Bernstein n'.Y.Univ. Med. Cent.). API Medical Research
Publicarion (8/1/77) (310 p.). 27-30966
Source: API Library The Effccts of Chronic Exposure to Carbon Monoxide (100 Ppm) on
the Cardiovascular System of Monkeys. [CRC-APRAC Project No.
27-30841 CAPM-4-68]. Cynomolgus monkeys exposed to 100 ppm carbon
Effects of Sulfate Aerosols upon Human Pulnionary Function. CRC monoxide showed changes in hematology and electrocardiograms after
APRAC Project CAPM-27-75. Human subjects exposed to ammonium three weeks, in contrast to previously studied mongrel dogs. The
sulfate. ammonium bisulfate, or sulfuric acid at levels simulating the electrocardiogram changes were greater in monkeys that had been
worst atmospheric conditions in the Los Angeles Basin did not suffer any subjected to induced myocardial infarction than in normal animals
adverse effects. In the tests. up to 16 normal, allergic, or asthmatic exposed to the carbon monoxide but, the effect began to wane after a
subjects were exposed for two days, two hours per day, to atmospheres peak at 12 weeks of exposure, compared lo a peak at 21 weeks of carbon
containing 100 pg/cu m ammoniuni sulfate. 85 pdcu m ammonium monoxide exposure in the normal monkeys. The electrocardiograms
disulfate, or 75 pgícu m sulfuric acid. The aninionium sulfate tests were reflect altered atrial depolarization, and the waves bear a strong
carried out at both 40 and 85% humidity and 88 "F. Effects were resemblance to those observed in pulmonary hypertension in man. In the
determined by a series of pulmonary function measurements and clinical monkeys not subjected to induced heart attack, the changes in the
observations. Graphs. diagrams. tables, and 35 references. (supported by electrocardiogram were not observed until 21 weeks. Graphs and tables.
Coord. Res. Counc. Inc.) (supported by Coord. Res. Counc. Inc.)
M. T. Kleinman; J. D. Hackney (Rancho Los Amigos Hosp.). API D. A. DeBias C. M. Banerjee N. C. Birkhead M. H. F. Friedman
Medical Research Pirblicaiion (7/3 1/78> (75 p.). (Jefferson Med. Coli.). API Medical Research Publicution (July 1972)
Source: API Library (45 P.).
Source: API Library
27-30842
Effects of Nitratc and/or Sulfate Acrosols upon Cardiopulmonary
Function. Final Report [for First Ycar of Project]. Five squirrel 27-31349
monkeys breathing 2.5 nig/cu ni aninionium sulfate for one hour at 25 Petrolcum Hydrocarbon Toxicity Studies-14. Animal and Human
"C and 40% relative humidity ammonium sulfate showed increased total Response to Vapors of "High Aromatic Solvent" indicate a hygienic
respiratory resishnce at the 95% confidence level. Preliminary data on standard of 26 ppm for the solvent. which has a boiling range of 364-403
-
exposure of the monkeys IO 4 mg/cu m of ammonium sulfate suggested -
"F and consists of 90% C,-C,, alkylbenzenes and 9% indanes. At the
that increases in lung tidal volume. decreases in breathing rate. and maximum vapor concentration obtainable, 0.38 m d . . 13 week exposure
possible changes in rate of nitrogen washout may result. At the lower did not affect rats or dogs adversely. as indicated by-hematology. clinical
concentration of ammonium sulfate exposure at 85% relative humidity chemistry. micropathology, and weight measurement of body, liver. and
did not cause a significant change in respiratory resistance. A prototype kidney. Exposing rats for eight hours to an aerosol containing 8.7 mfl.
high-capacity aerosol generator for human exposure studies was of the solvent resulted in death. Cats inhaling 8.2 r n g . aerosol for six
designed. It can produce 500 pg/cu m ammonium sulfate aerosols with hours gave signs of central newous system depression. Sniff tests with
an aerodynamic mass median diameter of 0.35 pm and 2780 pg/cu m six human subjects indicated an odor threshold of 0.07 ppm. Tables and
ammonium nitrate aerosols with 0.72 pm diameter. Graphs. tables. 16 references. (supported by API)
photographs, diagrams. and 65 references. (supported by Coord. Res. C. P. Carpenter. D. L. Geary; R. C. Myers; D. J. Nachreiner. L. J.
Counc. Inc.) Sullivan; J. M. King (Carnegic-Mellon Univ.), Toxicology and Applied
K. A. Bell; J. D.Hackney (Rancho Los Amigos Hosp.). API Medical Plrorniacology 41 :235-49 (1977).
Research Pirblication (6/7/76) (1 80 p.). Source: Not available f m API
Source: API Library
27-31350
2 7-30915 Petroleum Hydrocarbon Toxicity Studies-15. Animal Response to
Carcinogenic Potential of Petrolcum Hydrocarbons. A Critical Vapors of "High Naphthenic Solvent." A study led to recommenda-
Review of the Lilcrature includes discussion of polycyclic aromatic tions that concentrations higher than 2.1 mgll. should be avoided in
hydrocarbons; epidemiological studies; carcinogenicity studies of crude workrooms and that workers continuously exposed to 0.61 mgfl. should
oils, fuel oils and solvents. lubricating oils, white oils, waxes. high- undergo periodic physical examinations. The four-hour LCSO for rats was
boiling cracked aromatic oils. aromatic extracts, and bituminous residues; 5.3 mgfl. Rats tolerated 4.6 mfl. and dogs tolerated 3.8 mg/l. for six
a discussion of the relationship between composition and carcinogenic hours without visible discomfort. In rats exposed to 5.5 mg/l. for 6 hours
potency; and methods of estiniating and reducing carcinogenic hazard. per day, 5 days per week. for 13 weeks, there was a lowered body
Tables and 230 references. (supponed by API) weight gain initially and a 75% incidence of kidney tubules dilated with
E. Bingham; R. P. Trosset; D.Warshawsky (Univ. Cinci.). Journal of pink homogeneous debris. Exposure to 2.1 mg/l. or 0.61 mp/i. of solvent
Environmenml Pathology and Toxicologv 3:483-563. 1980 (1979). had no effect. Exposure to the solvent vapors at all concentrations caused
Source: Not available from API no differences in urinalysis, hematology, or blood chemistry. The "high
naphthenic solvent" has a boiling range of 315-361 "F and consists of
27-30965 70% naphthenes and 29% paraffins. Tables and 14 references. (supported
Final Report ofthe Study of the Relationship betwecn Carboxyhenio- by the API)
--``,``,,,``````,,``,`,,,`,``,-`-`,,`,,`,`,,`---

globin on Admission to the Subsequent Hospital Course of Patients C. P. Carpenter. D. L. Geaiy: R. C. Myers; D. J. Nahreiner. L. J.
Admlttcd to the Myocardial Infarction Research Unit at the Johns Sullivan; J. M. King (Carnegie-Mellon Univ.). Toxicology and Applied
Hopkins Hospital. [CRC-APRAC Project No. CAPM-13-69]. A study Pltarniocology 41 :25 1-60 (1977).
of 140 hean attack patients showed that recent smokers had higher Source: Not available f m API

76

COPYRIGHT 2003; American Petroleum Institute Document provided by IHS Licensee=Shell Services International B.V./5924979112,
User=, 05/20/2003 18:24:39 MDT Questions or comments about this message: please
call the Document Policy Management Group at 1-800-451-1584.
API P U B L X 4 6 3 4 95 0 7 3 2 2 9 0 055003b 2 L T

27-31351 systemic toxicity. but the subacuie dermai test produced acuie dermal
Petroleum Hydrocarbon Toxicity Studies-16. Animal Response to corrosion and obvious treatment-related signs at the 10 mikg dosage
Vapors of "Naphthenic Aromatic Solvent." No deaths occurred among level. Histopathologic examination of tissues confirmed dermal toxicity
rats exposed to an atmosphere of the highest attainable vapor concentra- at all dosage levels. The oral median lethal dose of the test material was
tion of "Naphthenic Aromatic Solvent", a blend of "70 solvent" and 21.2 mvkg. The primary skin irritation and eye irritation tesu were made
"High Naphthenic Solvent" contrived to furnish equal amounts of on white rabbits; the skin sensitization tests, on guinea pigs; the acute
aromatics and naphthenics. In an atmosphere saturated with vapor also dermal toxicity tests. on white rabbits; and the acute oral toxicity tests.
containing aerosol. rats typically exhibited salivation, loss of coordina- on albino rats. Tables.
tion, and mild tremors. Rats subjected to these conditions (4.5 mpfl.) for B L.S . Beck D. I. Hepler (Elars Biores. Lab.). APf Medical Research
6 hours daily. 5 days per week, for 62 days gained signiíicandy less Pitblicaïion (7/17/80) (52 p.),
weight than unexposed controls. Atmospheres containing 2.2 mg/i. or less Source: API Libraiy
of the solvent vapor had no effect. No solvent-related effects were noted
in urinalysis, hematology, blood cheniistry, or body weight measurements 2742127
of the rats. Comparison with data on other solvents indicates that Teratology Study in Rats. Shale Oil R03. Final Report [on LBI
naphthenes are toxic. that they are especially hazardous because they do Project No. 20726-R03]. Exposure of pregnant rats to air containing O.
not give any irritative warning signs, and that the toxic effects of 5.9. or 104.6 mg/cu m of shale oil R03 had no effect on the formation
aromatic and naphthenic components in a mixture are strictly additive. and development of the embryos, but caused significantly decreased food
Tables. (supported by the API) consumption and significantly decreased body-weight gain in the mothers
B C. P. Capenter, D. L. Geary; R. C. Myers; D. J. Nachreiner, L. J. at the 104.6 mglcu m level. The pregnant rats were exposed to shale oil
Sullivan; J. M. King (Carnegie-Mellon Univ.), Toxicology and Applied R03 on days 6 through 15 of gestation for 6 hr/day. The particle size of
Pharmacology 41 :26i -70 (1977). the aerosol was > 85% below 9 p. The effects on the fetuses were deter-
Source: Not available from A H mined by removing the uteri on day 20 of gestation and determining the
number and placement of implantations and resorptions, the number of
27-31352 live and dead feiuses. soft tissue changes, and skeletal abnormaliiies.
Petroleum Hydrocarbon Toxicity Studies-17. Animal Response to Tables. (supported by API)
n-Nonane Vapor. The acute four-hour LC50 for rats breathing il-iionane API Medical Research Piiblicarion (Nov. 1978) (22 p.).
vapor was 17 mgn., and the rats tolerated 4.6 mg/l. for four hours Source: API Library
without visible effect. Subjecting rats to inhalation of 8.4 mg/l. for 6
hours daily, 5 days per week, for 13 weeks caused salivation and 27-32128
lacrimation. and resulted in body weight gains significantly lower than Teratology Study in Rats. Shale Oil RO1. Final Report [on LBI
those of controls. Rats subjected to a similar regime at 3.1 mgfl. or 1.9 Project 20726-R01]. Exposing pregnant rats to air containing O. 5, or
mgA. of the solvent vapor did not differ from the controls. No 100 mg/cu m of shale oil R04 caused mottled lungs in the mothers at the
solvent-related effects were found in the blood. urine. or tissues of the 5 and 100 mglcu m levels, and produced evidence of embryo toxicity
rats. Tables and 17 references. (supported by the API) expressed as an increase in resorptions and accompanying parameters at
B C. P. Carpenter, D. L. Geary; R. C. Myers: D. J. Nachreiner. L. J. the 100 mg/cu m levei. The pregnant rats were exposed to shale oil R04
Sullivan; J. M. King (Carnegie-Mellon Univ.). Toxicology and Applied on days 6 through 15 of gestation for 6 hr/day. The particle size of the
Pharmacology 4453-61 (1978). oil aerosol was > 97.9% below 9 p. The effects on the fetuses were
Source: Not available from APl determined by removing the uteri on day 20 of gestation and determining
the nuniber and placement of implantations and resorptions. the number
27-31528 of live and dead fetuses, soft tissue changes, and skeletal abnormalities.
[Studies of the] Absorption, Distribution, and Excretion of Ethyl- Tables. (supported by API)
benzene [(En)]. Ethylcyclohexane [(ECH)],and Methyethylbenzene API Medical Research Publicarion (Feb. 1979) (27 p.).
[(MEB)] Isomers in Rats showed that the mean quantity of the three Source: API Library
compounds, all carbon-14 labeled. absorbed by three male Halan-Wistar
rats during 6 hr exposure to a 1 mgfl. concentration was 48.52. and 58
mg. respectively. Total (excretion and tissues) mean recoveries of 91.80, 27-32129
and 76% were obtained for EB, ECH, and MEB. respectively. Mean total Teratology Study in Rats. Shale Oil Rol. Final Report [on LBI
radioactivity remaining in the tissues was EB, 0.2%. ECH. 0.2%; and Project No. 20726-ROlI. Exposing pregnant rats to air containing O, 5,
MEB, 0.3%. In general, the highest retained amounts were observed in or 100 mg/cu m of shale oil R01 had no effea on embryo formation and
carcasses. the G-I tract. and liver, with fat (EB and ECH) and plasma development, but caused lung discoloration and decreased food consump-
W E B ) containing relatively high amounts. Excretion of radioactivity was tion values in the mothers at the i00 mgku m level. The pregnant rats
essentially complete for the three compounds within 24 hr after the start were exposed to shale oil R01 on days 6 through 15 of gestation for 6
of exposure. The major routes of excretion after 48 hr (72 hr for the first hr/day. The particle size of the oil aerosol was > 98% below 9 p. Effects
study with EB) was ihrough the urine (EB, 83%. ECH, 65%; and MEB. on the fetuses were determined by removing the uieri on day 20 of
71%). and expired gases (EB. 8%: ECH. 11%; and MEB. 1%). T h e gestation and determining the number and placement of implantations
remaining excretion routes of feces. CO,. and tissues contained only and resorptions. the number of live and dead fetuses, soft tissue changes,
minor amounts of the compounds. The quantity of MEB recovered in and skeletal abnormalities. Tables. (supported by API)
expired gases was IO-20% of that obtained by this route for the other API Medical Research Publicaïion (Feb. 1979) (27 p.).
two compounds. EB, ECH, and MEB are the principal components of Source: API Library
"60 Solvent" petroleum hydrocarbon mixture. Diagram. graph. Und tables.
B. H. Chin (Diamond Shanirock Corp.), J . A. McKelvey 27-32130
(Carnegie-MeUon Univ.). T. R. Tyler, L. J. Calisti. S. J . Kozbelt, L. J. [Project No. 14131 /Acute Toxicity Tests [ofl API #PS-6, Unleaded
Sullivan, Bullerin of Environnienral Contaniinaïion orrd Toxicology Motor Gasoline showed a slight primary skin irritation but no primary
24~477-83(1980). eye irritation on rabbits, and no skin sensitization on albino guinea pigs.
Source: Not available from API The acute dermal test produced skin irritation and no obvious signs of
toxicity. although the death of o