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LEMBAR JAWABAN

SKILLAB EVIDENCE BASED MEDICINE (EBM)

Nama : ATIKA AMALIAH


NIM : 04011381320020

Paramater Rata-Rata + 2SD Nilai Abnormalitas


SGOT/ SGPT 26.29 + 2(13.92) = 54.13 54.13 + 0.05 = 54,18
Hemaglobin 12.47 – 2( 0.32) = 11.83 11.83 – 0.05 = 11.78
Trigliserida 115.31 + 2 (20.04) = 155.39 155.39 + 0.05 = 155.46
Total Kolesterol 137.24 + 2 (32.40) =202.04 202.04 + 0.05 = 202.09
HDL 89.44 – 2(17.11) = 55.22 55.22 + 0.05 =
LDL 74.64 + 2 (13.63) = 101.90 101.90 + 0.05 = 101.95

2. Clinical Skenario
2.1. Tabel PICO
P Older Person with early sign/symtoms of cognitive
impairment
I Mini-cog screening test
C Mini Mental State Examination
O Accurate diagnosis of dementia or Alzheimer’s disease

2.2. Clinical question


In older adults with early signs/ symtoms of cognitive impairment, is
mini-cog test as accurate as MMSE in diagnosing or alzheimer’s
disease.

2.3. Search Term/ Search key word/ search strategy


(Mini-cog OR minicog) AND (Mini-mental state exam* OR MMSE
or SMMSE) AND (Alzheimer* OR dementia )
2.4. Searching di www.tripdatabase.com
2.5. Result of Searching
ABSTRACT COPY DISINI
2.6. Critical appraisal
Homework nilai uji diagnostik

3.
3.1 Grafik titik potong kreatinin kinase

Classification: MCI
100
90
80
70
60
Sensitivity (%)
50
Specificity (%)
40
30
20
10
0
40 50 60 70 80
KretaininKinase
KretaininKinase
100
Sensitivity: 100,0
Specificity: 92,0
Criterion : >69,1098
80
Sensitivity

60

40

20

0
0 20 40 60 80 100
100-Specificity

3.2.
Visually the graph show value of creatinin-kinase more than 80 and
less than 90
3.3.
Variable KretaininKinase
KretaininKinase

Classification variable MCI

Sample size 100

Positive group : MCI = 1 13

Negative group : MCI = 0 87

Disease prevalence (%) unknown

Area under the ROC curve (AUC)

Area under the ROC curve (AUC) 0,973

Standard Errora 0,0140

95% Confidence intervalb 0,919 to 0,995


z statistic 33,901

Significance level P (Area=0.5) <0,0001


a DeLong et al., 1988
b Binomial exact

Youden index

Youden index J 0,9195

Associated criterion >69,1098

Criterion values and coordinates of the ROC curve [Hide]

Criterion Sensitivity 95% CI Specificity 95% CI +LR -LR

≥40,0886 100,00 75,3 - 100,0 0,00 0,0 - 4,2 1,00

>69,1098 100,00 75,3 - 100,0 91,95 84,1 - 96,7 12,43 0,00

>70,1641 92,31 64,0 - 99,8 93,10 85,6 - 97,4 13,38 0,083

>72,9038 76,92 46,2 - 95,0 93,10 85,6 - 97,4 11,15 0,25

>73,2495 69,23 38,6 - 90,9 94,25 87,1 - 98,1 12,05 0,33

>75,2407 69,23 38,6 - 90,9 96,55 90,3 - 99,3 20,08 0,32

>76,5148 61,54 31,6 - 86,1 97,70 91,9 - 99,7 26,77 0,39

>76,8872 53,85 25,1 - 80,8 98,85 93,8 - 100,0 46,85 0,47

>77,4574 38,46 13,9 - 68,4 98,85 93,8 - 100,0 33,46 0,62

>77,995 30,77 9,1 - 61,4 100,00 95,8 - 100,0 0,69

>78,6751 0,00 0,0 - 24,7 100,00 95,8 - 100,0 1,00

PR LDL DAN MCI


4. Randomized clinical trial/ control trial Ace Inhibitor ( Uji Therapy Bad Outcome )

Tabel 3. Angka Kematian MCI kelompok placebo dan kelompok ACE Inhibitor

Treatment alive dead total


Ace inhibitor 44 6 50
placebo 37 13 50
Total 81 19 100

4.1.

CER = 0.74

EER = 0.88

ARR = 0.14 ( CER – EER )

RRR = 0.189

NNT = 7.143 (1/RRR )

ARTINYA ?

4.2. Kesimpulan....

5. HOMEWORK

5.1.

5.2.