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Research and development of medicinal plants both at domestic and abroad is growing

rapidly, especially in the field of pharmacological properties of one of them as a depressant

(sedative). One of the plants that have been used empirically as traditional medicine are the
leaves of Moringa (Moringa oleifera). Moringa plant has been studied extensively for a
variety of potential use of drugs including depressants. Islam talks about God creating the
diverse plant has its own wisdom and purpose behind it.
This study aims to prove that the extract of leaves of Moringa (Moringa oleifera) has
potential as a depressant.
The research method used hanging test and elevated plus maze (EPM) test. Total mice used
were 48 animals, divided into six groups, each group consisting of four mice. Group I:
control (water); Group II: Standard (diazepam 10 mg / kg orally); Group III ethanol extract of
leaves of Moringa 50 mg / kg, IV ethanol extract of Moringa leaves 100 mg / kg, V ethanol
extract of Moringa leaves 200 mg / kg and VI of ethanol extract of Moringa leaves 400 mg /
kg. Ethanol extract of Moringa leaves and diazepam will be administered orally 1 hour prior
to the experiment.
Hanging test were analyzed using statistical test of Kruskal-Wallis and Mann-Whitney. In the
test on the elevated plus maze (EPM) test performed statistical tests One Way ANOVA with
advanced duncan test. The results obtained in the test stage showed significant differences (P
<0.05) in the treatment group a dose of 50 mg / kg, a dose of 100 mg / kg and 200 mg /
kgBB.dan no significant difference between treatment groups (p> 0.05 ) on the elevated plus
maze (EPM) test.
The ethanol extract of leaves of Moringa cause central nervous system depressant effects of
mice in both tests. The Islamic view has different opinion about ethanol extract leaves of
Moringa for treatment.
Keywords : Moringa leaves, depressants, Hanging Test, Elevated Plus Maze (EPM)