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1. Which of the following is not one of the states of 7.

Which of the following is an example of


lipids? peripheral membrane protein?
a. Para crystalline state a. Insulin receptor
b. Liquid ordered state b. Glycophorin
c. Liquid disordered state c. Integrin
d. Crystalline state d. Glycolipid transfer proteins

2. Which of the following arrangement based on the 8. Which of the following proteins does not function
increasing order of motion is correct? in cell- cell interaction?
a. Uncatalysed transverse motion, a. Integrin
transverse diffusion catalyzed by b. Cadherin
flippase, uncatalysed lateral diffusion c. N-CAM
b. Uncatalysed lateral diffusion, d. Cytochrome c
uncatalysed transverse motion,
transverse diffusion catalyzed by 9. Which of the following integral membrane
flippase, protein is a special class of membrane rafts?
c. Uncatalysed transverse motion, a. Caveolin
uncatalysed lateral diffusion, transverse b. Integrin
diffusion catalyzed by flippase c. Cadherin
d. Transverse diffusion catalyzed by d. Selectin
flippase, uncatalysed lateral diffusion,
uncatalysed transverse motion, 10. Which of the following is one of the family of
immunoglobin like proteins that mediate Ca2+?
3. Movement of phospholipids from side to side is a. N-CAM
called b. Integrin
a. Facilitated diffusion c. Cadherin
b. Lateral diffusion d. Selectin
c. Transverse diffusion
d. Simple diffusion 11. Erythrocyte glucose transporter is an example of
a. Ion driven active transport
4. Movement of phospholipids to opposite sides is b. Facilitated diffusion
called c. Active transport
a. Facilitated diffusion d. Simple diffusion
b. Lateral diffusion
c. Transverse diffusion 12. Which out of the following is not a mediated
d. Simple diffusion transport?
a. Facilitated diffusion
5. Trans bilayer diffusion is also called b. Primary active transport
a. Facilitated diffusion c. Secondary active transport
b. Lateral diffusion d. Simple diffusion
c. Flip flop
d. Simple diffusion 13. Na+ glucose transporter is an example of
a. Symport
6. Which of the following is an example of b. Antiport
heterodimeric protein? c. Facilitated diffusion
a. Integrin d. ATP driven active transport
b. Antibodies
c. Receptor tyrosine kinase 14. Which of the following is energy independent?
d. G-protein coupled receptor a. Active transport
b. Primary active transport
c. Secondary active transport
d. Passive transport
15. Semipermeable membrane allows 22. Signal molecule fits the binding site on its
a. Solute to pass complementary receptor called as
b. Solution to pass a. Specificity
c. Solvent to pass b. Amplification
d. Proteins to pass c. Integration
d. Cooperativity
16. When does saturation occur?
a. When molecules are moved by the use 23. Number of affected molecules increases
of vesicles geometrically in an enzyme cascade in
b. When the energy from a high-energy a. Specificity
bond is required to move molecules b. Amplification
c. When a group of carrier proteins is c. Adaptation
operating at its maximum rate d. Integration
d. When a carrier molecule has the ability
to transport only one molecule or a 24. Receptor is removed from cell surface in
group of closely related molecules a. Specificity
b. Amplification
17. In which of the following means of transport a cell c. Adaptation
expels large molecules out of it? d. Integration
a. Phagocytosis
25. Regulatory outcome results from integrated input
b. Exocytosis
from both receptors is in
c. Endocytosis
a. Specificity
d. Diffusion
b. Amplification
c. Adaptation
18. HCO3– – Cl– transporter is an example of
d. Integration
a. Uniport
b. Antiport 26. Acetylcholine receptor ion channel is an example
c. Symport of
d. Facilitated diffusion a. Gated ion channel
b. Receptor enzymes
19. Which of the following transports only one kind of c. Membrane protein
substrate? d. Nuclear protein
a. Uniport carriers
b. Symport carriers 27. How many types of signal transducers are there?
c. Antiport carriers a. 3
d. Membrane proteins b. 4
c. 5
20. Which of the following induces conformational d. 6
change in protein? 28. Which of the following is a nuclear receptor
a. Uniport protein?
b. Symport a. Steroid receptor
c. Antiport b. Adhesion receptor
d. Facilitated diffusion c. Serpentine receptor
d. Receptor with no intrinsic enzyme
21. The information which is represented by a signal activity
is detected by specific receptors and converted to
a cellular response; this conversion is called 29. Receptor proteins that indirectly activate
a. Signal amplification enzymes that generate intracellular second
b. Signal transversion messengers are
c. Signal transduction a. Steroid receptors
d. Signal integration b. Serpentine receptors
c. Adhesion receptors
d. Receptor enzymes
30. Insulin receptor is an example of 37. Depolarization and repolarization changes that
a. Steroid receptors occur during the action potential are produced by
b. Serpentine receptors a. Negative feedback loops
c. Adhesion receptors b. Carrier mediated transport
d. Receptor enzymes c. Simple diffusion of ions down their
concentration gradient
31. Which of the following statements is true about d. Active transport pumps along the
transmembrane electrical potential? neuron membrane
a. The chemical gradient drives Cl– and K+
inwards 38. Diffusion of K+ out of the cell makes the inside of
b. The electrical gradient drives Na+ and it less positive, or more negative and acts to
Ca2+ inwards restore the original resting membrane potential.
c. The chemical gradient drives Na+ and This process is called
Ca2+ inwards and K+ outward a. Repolarization
d. The chemical gradient drives Cl– and K+ b. Depolarization
outwards c. Hyperpolarization
d. Overshoot
32. Nicotinic acetylcholine receptor is an example of
a. Ligated gated receptor channel 39. Which of the following statements about action
b. Serpentine receptors potential is false?
c. Adhesion receptors a. Na+/K+ pumps are directly involved in
d. Receptor enzymes creating the action potential
b. Na+ and K+ concentrations are not
33. Which of the following are intracellular second
significantly changed during an action
messengers?
potential
a. Acetylcholine
c. This includes both positive and negative
b. Glycine
feedback loops
c. IP3
d. Only a relatively small number of Na+
d. Glutamate
and K+ actually diffuse across the
34. The receptor channels for which of the following membrane
are gated by extracellular ligands?
a. Glycine 40. Which out of the following is not a
b. IP3 neurotransmitter?
c. cAMP a. Noadrenaline
d. cGMP b. Cyclic AMP
35. Which of the following statements is false about a c. Dopamine
ligand-gated ion channel receptor? d. Acetyl choline
a. They are present in the cell membrane
b. They consist of five glycoproteins 41. SH2 domain specifically binds to
c. Differences in membrane potential a. GDP
affect whether the channel receptors b. Ca2+
are open or close c. Phosphorylated tyrosine residues
d. Neurotransmitters can act as the d. Phosphorylated serine residues
chemical messengers for these channels
42. cAMP and cGMP are derived from
36. Voltage regulation means a. ATP and GTP by the actions of
a. Na+/K+ pumps controls potential guanylate cyclase and adenylate cyclase
b. Unless the voltage is regular gates will respectively
not respond b. ATP and GTP by the actions of
c. Oscilloscope only can control potential adenylate cyclase and gualnlate cyclase
d. With changes in the membrane respectively
potential voltage gated ion channels
open and close
c. GTP and ATP by the actions of 50. Ras protein is a
adenylate cyclase and guanylate cyclase a. G-protein switch
respectively b. Small monomeric GTPase switch
d. None protein
c. Serine-threonine kinase
43. Which of the following is false about d. Tyrosine kinase
phosphorylation by IRS on serine residue?
a. It is an inhibitory phosphorylation 51. Which out of the following statements is true
b. It is molecular mechanism for insulin about G-protein couple receptors?
resistance a. The N-terminal chain is extracellular
c. It increases insulin levels and C-terminal chain is intracellular
d. Target tissues fail to respond to b. It contains 5 trans-membrane
circulating insulin hydrophobic sections
c. There are more extracellular loops than
44. The enzyme activated by cyclic AMP, passing on intracellular loops
the hormonal signal is d. The binding region for G-protein
a. Protein kinase B involves 2 extracellular loops
b. Protein kinase A
c. Protein kinase C 52. Which of the following is not a G-protein coupled
d. G protein receptor kinase receptor?
45. Protein kinase ERK is activated by a. Glycine receptor
phosphorylation of b. Adrenergic receptor
a. Only Thr c. Glutamate receptor
b. Only Tyr d. Muscarinic receptor
c. Both Thr and Tyr
d. Only Ser 53. Protein kinase A is
a. Completely inhibited by cyclic AMP
46. Activation of guanylyl cyclase produces b. Allosterically activated by cyclic AMP
a. Guanosine 3’, 5’-cyclic monophosphate c. Affected by cyclic AMP only under
b. Guanosine 2’, 5’-cyclic monophosphate unusual circumstances
c. Guanosine 4’, 5’-cyclic monophosphate d. Activated by covalent binding of cyclic
d. Guanosine 1’, 5’-cyclic monophosphate AMP
47. cGMP-dependent protein kinase is also called
54. Which out of the following is not involved in
a. Protein kinase B
signal transduction by β-adrenergic receptor
b. Protein kinase A
pathway?
c. Protein kinase G
a. GTP
d. Protein kinase C
b. ATP
c. cAMP
48. Which of the following is not responsible of
d. cGMP
producing diarrhea?
a. Elevation in [cGMP]
55. Which of the following catalyzes the cutting of
b. Increase in Cl– secretion
PIP2 into 2 moles of IP3 and diacylglycerol in cell
c. Decrease in reabsorption of water by
signaling?
the intestinal epithelium
a. Phosphokinase C
d. Decrease in Cl– secretion
b. Phospholipase C
c. Lipokinase
49. Which of the following is a short-lived messenger
d. Phosphodiesterase C
that acts by stimulating a soluble guanylyl cyclase,
raising [cGMP] and stimulating PKG?
a. NO
b. NO2
c. NO3–
d. N2O
56. The binding of ligands to many GPCRs leads to 62. Which of the following directly phosphorylate
a. Decrease in concentration of certain tyrosines to start a kinase protein enzymatic
intracellular signal molecules called cascade?
second messengers a. Receptor tyrosine kinase
b. Increase in concentration of certain b. Receptor guanylyl cyclases
intracellular signal molecules called c. Receptor serine kinase
second messengers d. Receptor threonine kinase
c. Decrease in concentration of certain
extracellular signal molecules called 63. PTB domains bind to
first messengers a. Phosphorylated tyrosine
d. Increase in concentration of certain b. Phosphoryated threonine
extracellular signal molecules called c. Phosphorylated serine
first messengers d. Phosphorylated cysteine

57. A hormone or ligand can be considered as 64. Scaffold protein in insulin signal transduction
a. First messenger a. KSR
b. Second messenger b. IRS-1
c. Third messenger c. MEKK1
d. Fourth messenger d. AKAP

58. Which of the following serves as a 65. Which of the following is involved in extrinsic cell
neurotransmitter in adrenergic neurons? death pathway?
a. Serotonin a. Heterotrimeric G protein complex
b. Epinephrine b. TRADD
c. Dopamine c. IRS-1
d. Histamine d. Protein-kinase A
66. Which of the following converts GTP to cGMP to
59. Which second messenger signals the release of
start its enzymatic cascade?
Ca+2 from endoplasmic reticulum?
a. Receptor guanylyl cyclase
a. IP3
b. Receptor adenylyl cyclase
b. 1,2 diacyl glycerol
c. Calmodulin
c. cAMP
d. Protein kinase-A
d. cGMP
67. Which of the following are stimulated to become
60. GPCR is comprised of membrane associated upon binding of insulin to
a. 7 transmembrane helices the insulin receptor?
b. 8 transmembrane helices a. PH-domain
c. 9 transmembrane helices b. PTB
d. 10 transmembrane helices c. SH3
d. SH2
61. The specificity of signaling pathways does not 68. Which of the following is involved in phospho-
include tyrosine binding?
a. Migration of signal proteins into a. SH2
membrane rafts b. SH3
b. Assembly of large multiprotein c. PTB
complexes d. PH
c. Phosphorylation of target proteins at
Ser, Thr/Tyr residues 69. Which of the following is involved in proline rich
d. Flippase-catalyzed movement of motif binding?
phospholipids from the inner to the a. SH2
outer leaflet b. SH3
c. PTB
d. PH
77. In Arabidopsis flg22 binds to
70. Which of the following is not a downstream a. FLS2
component? b. LPS
a. Ras c. BAK1
b. MEK d. MAPK
c. ERK
d. PIP3 78. Transcription factor in plants is
a. Serine
71. Which of the following statements about b. Threonine
Arabidopsis is not true? c. WRKY22/29
a. In Arabidopsis, CTR-1 Ser/Thr protein d. Leucine
kinase is activated by ethylene
b. Activation of MAPK cascade 79. Negative regulator of ethylene response
c. EINI activation a. LPS
d. Synthesis of ERF1 transcription factor b. CTR1
c. BAK1
72. The 2-component system drives bacterial d. MAPK
chemotaxis by coupling autophosphoryaltion of
which receptor to phosphorylation of respective 80. ERF1is a
regulatory protein? a. Translation terminating factor
a. His kinase b. Positive regulator
b. Adenylyl cyclase c. Translation promoting factor
c. Guanylyl cyclase d. Enzyme inhibitor
d. None
81. The G protein involved in visual signal
73. Bacteria do not have which of the following transduction is
receptors a. Rhodopsin
a. Adhesion receptors b. GTP receptor
b. Nuclear steroid receptors c. Arrestin
c. Membrane proteins d. Transducin
d. GPCR
82. Cholera toxin is not a/an
74. A factor involved in regulating the fate of stem a. Enzyme inhibitor
cells in plant development b. Enzyme activator
a. Adrenaline c. Enzyme modifier
b. Epinephrine d. Toxin released from bacteria in the
c. Thyroid stimulating hormone infected intestine
d. CLV1
83. In cholera there is uncontrolled secretion of
75. The peptide trigger for the self-incompatibility a. Na+ and H2O
response that prevents self-pollination b. K+ and H2O
a. Salicylic acid c. Ca2+ and H2O
b. Jasmonates d. Mg2+ and H2O
c. Brassinosteroids
d. Plant peptide hormones 84. Vision, olfaction and gustation employ
a. Serpentine receptors
76. Autophosphorylation is done on b. Enzyme coupled receptors
a. His residues c. Ligand gated receptors
b. Ser/Thr residues d. Adhesion receptors
c. Cys residues
d. Lys residues
85. Which out of the following statements about 91. When visual stimulus reaches receptors in retina
sense of smell is not true? of eye, second process involving absorption of
a. Olfactory receptor cells are bipolar physical energy by receptors is
neurons, not replaced when damaged a. Reception
b. The chemicals are received by specific b. Transduction
plasma membrane receptors in c. Coding
olfactory receptor cells d. Adaptation
c. Olfactory receptors do not adapt
quickly 92. How do steroid hormones produce their effects in
d. The main areas of brain that interpret cells?
sense of smell be in the temporal and a. By activating key enzymes in metabolic
frontal lobes pathway
b. By binding to intracellular receptors and
86. Most olfactory receptors are located on the promoting transcription of specific
a. Superior surface of nasal cavity genes
b. Interior surface of nasal cavity c. By promoting degradation of specific m-
c. Lateral surface of nasal cavity RNAs
d. Medial surface of nasal cavity d. By activating translation of certain m-
RNAs
87. Objects are perceived by photo receptors because
rods or cones 93. An example of positive regulator
a. Depolarize a. CAP
b. Hyperpolarize b. Lac 1 gene
c. Repolarize c. Trp operon
d. Polarize d. Met operon

88. Which of the following statements is not true 94. An example of negative regulator
about olfactory neurons? a. CAP
a. Axons of olfactory neurons combine to b. Lac 1 gene
form olfactory nerves c. Nuclear receptors
b. They synapse with cells in olfactory bulb d. Phosphorylated STAT proteins
c. They have receptors that react with
odorants dissolved in fluid 95. Steroid regulatory proteins mediate the act by
d. They are uni-polar neurons binding at
a. Zinc finger motif
89. What is the relationship between olfactory b. Leucine zipper motif
sensors and gustatory sensors? c. Helix turn helix motif
a. Gustatory hair can also detect odorants d. Histone helix motif
b. Olfactory hair can also detect tastants
c. Olfactory sensors provides information 96. Which out of the following statements is true
about substance that we are about to about gene regulation in bacteria?
taste a. Repressor protein blocks transcription
d. No relation by binding to operator sequence
b. Activator proteins bind near promoters
90. When visual stimulus reaches receptors in retina and increase the efficiency of
of eye, first process involving absorption of transcription
physical energy by receptors is c. Enhancers commonly regulate
a. Reception transcription
b. Transduction d. Genes with related functions are often
c. Coding grouped together and have a single
d. Adaptation start codon
97. Steroid hormones receptor binds to
a. Hormone response elements in m-RNA
b. Hormone response elements in DNA
c. Hormone response elements in
proteins
d. Ribosomes to stimulate translation
e. Cell membrane thereby increases
permeability

98. Mode of action of steroid hormones involve


a. Stimulation of DNA replication
b. Stimulation of m-RNA transcription
c. Inhibition of protein synthesis
d. Secondary messenger

99. The drug antagonist of estrogen is


a. Tanoxifen
b. Metformin
c. Glucophage
d. Victoza

100. The drug used to terminate early pregnancies is


a. RU486
b. Metformin
c. Glucophage
d. Victoza

101. Plasma membrane protein predicted to have seen


7 transmembrane helices segment binds
a. Progesterone
b. Thyroid stimulating hormone
c. Insulin
d. Follicle stimulating hormone
ANSWER KEY 53. B
1. D 54. C
2. A 55. B
3. B 56. A
4. C 57. A
5. C 58. B
6. A 59. A
7. D 60. A
8. D 61. D
9. A 62. A
10. A 63. A
11. B 64. B
12. D 65. B
13. A 66. A
14. D 67. A
15. C 68. A
16. C 69. B
17. B 70. D
18. B 71. A
19. A 72. A
20. D 73. B
21. C 74. D
22. A 75. C
23. B 76. B
24. C 77. A
25. D 78. C
26. A 79. B
27. D 80. A
28. A 81. C
29. B 82. B
30. D 83. A
31. C 84. A
32. A 85. C
33. C 86. A
34. A 87. B
35. C 88. D
36. D 89. C
37. D 90. A
38. A 91. B
39. B 92. B
40. B 93. A
41. C 94. B
42. B 95. A
43. C 96. A
44. B 97. B
45. C 98. B
46. A 99. A
47. C 100. A
48. D 101. A
49. A
50. B
51. A
52. A