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Autologous PRP Eye Drop


INTRODUCTION production and safety of this intervention in patients with
Platelet rich plasma (PRP) is an autologous solution severe dry eye.
comprised of a high concentration of platelets and WBC’s
suspended in plasma. Platelets, or Thrombocytes, are a natural WHAT ARE AUTOLOGOUS PRP EYE DROPS
source of growth factors. When activated, these platelets The patients who have been unable to obtain relief through
release a large variety of known growth factors that accelerate other methods may have success with this treatment. The
the body’s natural healing process. treatment is very safe and effective for the treatment of
Platelet rich plasma (PRP) application is a successful catalyst chronic and symptomatic Dry Eye Syndrome. Other
in the healing process for wide varieties of conditions. PRP indications for the use of Autologous PRP Eye Drops may
was first developed in the 1970s and first used in an open include Ulcers and Ocular Surface Syndrome Post LASIK.
heart surgery procedure. PRP therapy began gaining Autologus E-PRP eye drops are prepared from patient’s own
popularity in the mid 1990s. Methods of harvesting and using blood and takes 2-3 hours to prepare activated E-PRP. Finally
platelet rich plasma are becoming widely practiced in the it is combined in the antibiotic or lubricant drops and should
fields of sports medicine, orthopedics, traumatology, general be stored in refrigerator and used within 7 days.
surgery, dentistry, dermatology and cosmetology and BENEFITS OF AUTOLOGOUS PRP EYE DROPS
ophthalmology. Accelerated and enhanced healing
Their main function is hemostasis by attaching to any breach Reduced inflammation
in vessel where platelets aggregate, activate and release Symptomatic improvement of Dry Eye Syndrome
granules. The platelets organelle zone is rich in platelet Effective in treating ulcers
granules. Alpha granules contain clotting mediators such as Reduction in pain
factor V, factor VIII, fibrinogen, fibronectin, platelet-derived May restore the corneal epithelial surface in patients with
growth factors, and chemotactic agents. Delta granules, or corneal ulcers
dense bodies, contain ADP, calcium, serotonin, which are The known contraindications for Autologous PRP eye drops:
platelet-activating mediators. Activated platelets release Platelet Dysfunction Syndrome
granules by exocytosis which contain not only clotting factors Critical Thrombocytopenia
but more than sixty different biologically active substances Hypofibrinogenemia
that are involved in processes of tissue regeneration, Ongoing Dry Eye Infection
angiogenesis, epithelialization, proliferation and
differentiation of osteoblasts, and in synthesis of collagen and Alio J, Colecha J, et al. Symptomatic Dry Eye Treatment with Autologous Platelet-Rich
extracellular matrix of connective tissue. Plasma. Ophthalmic Res 2007; 39: 124-129.
Alio J, Pastor S, et al. Treatment of Ocular Surface Syndrome after LASIK with
Dry Eye Syndrome : Autologous Platelet-rich Plasma. Journal of Refractive Surgery 2007; 23: 617-619.
Dry eye is a chronic condition that decreases function and Alio J, Abad M, et al. Use of Autologous Platelet-Rich Plasma in the Treatment of
affect visual function with severe discapacity until now Dormant Corneal Ulcers. Ophthalmology 2007; 114: 1286-1293.
Koffler B. Autologous Serum Therapy of the Ocular Surface with Novel Delivery by
treatments are based in artificial eye drops. Platelet rich Platelet Concentrate Gel. The Ocular Surface 2006; 4(4): 188-195.
plasma has emerged as a strategy for cellular restoration, the Marquez-de-Arecena R, Montero-de-Espinosa I, et al. Subconjunctival Application of
Platelet Rich Plasma Concentrate in the Treatment of Ocular Burns: Preliminary
purpose of this study is to evaluate their effects in lacrimal Results. Arch Soc Esp Oftalmol 2007; 82: 475-482.

Please contact Dr. S K Hayatnagarkar, Cryobank Fertility Research Centre,

Kamgar Chowk, N-2, CIDCO Aurangabad Cell and whatsapp: 9422725000,