Chapter 16 - Disorders in Immunity

Chapter 16 Disorders in Immunity

Multiple Choice Questions 1. The major categories of hypersensitivities that typically involve a B-cell immunoglobulin response is/are A. Type 1 only. B. Type 1 and Type 4. C. Type 4 only. D. Type 1, Type 2, Type 3. E. Type 1, Type 2, Type 3, and Type 4.

2. Atopy and anaphylaxis are hypersensitivities in the category A. Type 1 only. B. Type 1 and Type 4. C. Type 4 only. D. Type 1, Type 2, Type 3. E. Type 1, Type 2, Type 3, and Type 4.

3. All of the following are involved in Type 2 hypersensitivity except A. IgM. B. IgG. C. IgE. D. complement. E. foreign cells.


E. A person who has anti-A and anti-B serum antibodies will have blood type A. C.Chapter 16 . recipient antibody activating the complement cascade to attack the RBCs. A. could not have the Rh factor. anti B E. O. anti Rh C. lacks antibodies to A and B blood types. MHC genes. 5. genetically determined glycoprotein markers. anti Rh 6. anti Rh B. Human blood types involve all the following except A. B. The serum of a person with blood type A. Rh.will have which of the following? A. All of the choices are correct. A person with O type blood A. inheritance of two of three possible alleles. B. D. 7. D. anti B. E. Transfusion of the wrong blood type can cause A. is called a universal recipient. B. anti A D. genes that code for an enzyme that adds a terminal carbohydrate to RBC receptors. 16-2 . C. E. AB. 8. ABO antigen markers. D. B. lacks A and B antigens. anti A. Rh.Disorders in Immunity 4. anti B. C. anti A.

E. 12. All of the choices are correct. 10. D. maternal Rh. The potential for hemolytic disease of the newborn occurs when A. fetal Rh+ cells enter an Rh. Inhalant 16-3 .cells enter an Rh+ fetus. birth by cesarean section. None of the choices are correct.fetus. C. massive hemolysis of the donor RBCs. B. injecting the mother with antibodies against the Rh factor late in the pregnancy and after giving birth. Erythroblastosis fetalis can be prevented by A. systemic shock and kidney failure. 11.mother. C. B.Disorders in Immunity B. D. C. A female who is Rh+ A. fetal Rh. E. Bee sting venom is considered to be which type of allergen? A. D. Ingestant B. All of the choices are correct. treating the mother with RhoGAM early in the pregnancy. inherited two recessive genes. B. is in the majority of the population with regard to Rh status. can only have an Rh positive baby.cells enter an Rh+ mother. fever and anemia. 9. C. E. D. E.Chapter 16 . treating the fetus with immune globulin. fetal Rh+ cells enter an Rh+ mother. maternal Rh+ cells enter an Rh. is at risk for a pregnancy resulting in hemolytic disease of the newborn.

Histamine acts on smooth muscle 16-4 . degranulation B. provocative dose. Contactant E. D. bonding of allergen to adjacent IgE binding sites on mast cells and basophils C. The initial encounter with an allergen is called the A. binding of IgE by the Fc region to mast cells and basophils D. B. Binding of IgE by the Fc region to mast cells and basophils D. Which event is the process of releasing chemical mediators? A. None of the choices are correct.Chapter 16 . prostaglandins cause vasodilation and increased vascular permeability 16. C.Disorders in Immunity C. None of the choices are correct. What will be the immediate action of allergen when it enters the body for a second time? A. hypersensitivity dose. Injectant D. Mold spores and animal dander are considered to be which type of allergen? A. Ingestant B. 13. Contactant E. 14. Degranulation B. desensitizing dose. Inhalant C. allergic dose. E. sensitizing dose. 15. histamine acts on smooth muscle E. Injectant D. Binding of allergen to adjacent IgE binding sites on mast cells and basophils C.

Poison ivy dermatitis . autoimmune disease. Prostaglandins cause vasodilation and increased vascular permeability 17. Fod allergy . diarrhea E. C.Disorders in Immunity E.Type 3 hypersensitivity D. B. 18. hypersensitivity. They are found mainly in the lymph nodes.Type 2 hypersensitivity E. Serum sickness . E.Type 4 hypersensitivity C. rashes C. sneezing D. They degranulate when triggered by a specific allergen through the IgE bound to them.Type 4 hypersensitivity 20. They carry high numbers of cell receptors that bind to IgE antibodies. transfusion reaction. B. None of the above is incorrect. rhinitis B. 16-5 . C. contact dermatitis 19. Transfusion reaction . D. Which is mismatched? A. Which of the following is not a possible symptom of Type I hypersensitivity? A.Type I hypersensitivity B.Chapter 16 . Which of the following is incorrect about the role of mast cells and basophils in allergies? A. immunodeficiency. Hay fever . D. Their cytoplasmic secretory vesicles contain physiologically active cytokines. Any heightened or inappropriate immune response resulting in tissue damage is called a/an A.

B. reverses constriction of airways. wheal and flare reaction in skin. C. prostaglandin. leukotriene.and mast cell-mediated allergy except A. is an antihistamine.Disorders in Immunity E. causes desensitization. 24. platelet-activating factor. Histamine causes all the following except A. C. E. D. The chemical mediator that causes prolonged bronchospasm. eczema. All of the following are associated with IgE. E. and mucus secretion of asthmatic patients is A. systemic lupus erythematosus. C. drug allergy. increased sensitivity to light. constriction of smooth muscle of bronchi and the intestine. histamine. desensitization. Epinephrine A.Chapter 16 . E. B. relaxes vascular smooth muscle. 16-6 . E. All of the choices are correct. 21. C. D. B. vascular permeability. 22. anaphylaxis. 23. inhibits the activity of lymphocytes. allergic asthma. D. B. D. pruritis and headache. serotonin.

controlled injections of specific allergens are undergoing A. tissue matching. serum sickness. allografts of skin. E. C. delayed hypersensitivity. frequent transfusions of Rh+ blood. Treatment for agammaglobulinemia is A.Chapter 16 . B. passive immunotherapy and continuous antibiotic therapy. tuberculin reaction. Autoantibodies cause tissue injury in all the following diseases except A. D. B. sensitization. multiple sclerosis. All of the choices are correct. bone marrow transplant. rheumatoid arthritis. C. degranulation. Large quantities of antibodies that react to the second entry of antigen and lead to formation of antigen-antibody complexes that deposit in basement membranes occur in A. 27. anaphylaxis. E. B. 26. hemolytic disease of the newborn. 16-7 . D. E. None of the choices are correct. E. 28. continuous immunosuppressive therapy. D. B. myasthenia gravis. desensitization. C. C. Graves' disease. Allergic patients receiving small. D.Disorders in Immunity 25.

allergen entering the skin. itchy papules and blisters. 16-8 . This can be a consequence of a genetic deficiency in B cell survival and maturity A. Formation of autoantibodies D. When grafted tissue such as bone marrow contains passenger lymphocytes what could result? A. E. host rejection of graft B. None of the choices are correct. 31. Contact dermatitis involves A. a sensitizing and provocative dose. The DiGeorge syndrome is the result of A. 32. formation of autoantibodies D. autoantibodies. failure of B cell development and maturity. 30. D. T lymphocytes secrete inflammatory cytokines. E.Chapter 16 . D. Host rejection of graft B. delayed hypersensitivity. C. Hypogammaglobulinemia E. graft versus host disease C. Graft versus host disease C. a genetic defect in the development of both T cells and B cells. None of the choices are correct. B.Disorders in Immunity 29. All of the choices are correct. congenital absence or immaturity of the thymus gland. B. hypogammaglobulinemia E. C.

E. Type I diabetes. D. B. D. 36. B. autoantibodies. a genetic defect in the development of both T cells and B cells. All of the choices are correct. 35. cytotoxic T cells. 34. Severe combined immunodeficiencies (SCIDs) are due to A. Chemotherapy C. C. C. AIDS.Chapter 16 . Organic disease D. natural killer cells. failure of B cell development and maturity. A secondary acquired immunodeficiency is A.Disorders in Immunity 33. B cells. D. E. DiGeorge syndrome. 16-9 . C. Which of the following can causes secondary acquired immunodeficiencies in T cells and B cells? A. macrophages. All of the following operate in surveillance and destruction of tumor cells except A. delayed hypersensitivity. congenital absence or immaturity of the thymus gland. Infection E. Radiation B. adenosine deaminase (ADA) deficiency. agammaglobulinemia. B.

Common childhood diseases can be fatal in affected children. Symptoms include reduced growth and unusual facial characteristics. between individuals of different species. Allograft B. It is severe deficiency of T cells. An acute response to a second injection of vaccines at the same site. The name given to skin wheals that occur during an allergy skin test. from one site on the body to another site. What is the Arthus reaction? A. 39. None of the choices are correct. Which is incorrect about DiGeorge syndrome? A. The lysis of RBC due to complement during an incorrect blood transfusion. Autograft D. between siblings. Jose needs a kidney due to his diabetes. between identical twins. D. 40. E. Xenograft C. 38. B. A positive tuberculosis skin test.Disorders in Immunity 37.Chapter 16 . Sometimes it is associated with a deletion in chromosome 22. Heterograft E. 16-10 . B. An autoimmune disorder. A xenograft is a tissue exchange A. E. His sister is a close match and is willing to give him one of hers. The major therapy is a bone marrow transplant. B. C. C. What type of transplant is this? A. D. D. C.

persons with this type of blood are considered universal donors. Histamine 44. persons with this type of blood have anti-A and anti-B antibodies in their additive 42. C. T cells B. Bradykinin B.vaccine D. Which of these chemicals is a powerful inflammatory agent that also stimulates uterine contractions? A. Ingestant .rubber E. 16-11 . All of the following are correct about Type O blood except A. this is the most common blood type among all racial groups in the U. Inhalant . Leukotriene E.Disorders in Immunity 41. Platelet-activating factor C. Ingestant . Contactant .nuts B. B. Which cells play the greatest role in allergic symptoms? A. Injectant . D. mast cells E. eosinophils 43. Which of the following is mismatched? A.bee C.Chapter 16 . monocytes C. Prostaglandins D. plasma cells D. persons with this type of blood carry an O antigen on their RBC.

autograft. B. macrophages. B. 46. heterograft. xenograft. 47.Disorders in Immunity 45. E. E. natural killer cells. multiple sclerosis. D. allograft. C. The heart of a baboon transplanted to a human would be a A. The tuberculin reaction develops within 30 minutes of the skin test in people with prior sensitization due to tuberculosis infection. All of the following cells participate in immune surveillance except A. homograft. C. All of the choices participate. C. True / False Questions 48.Chapter 16 . FALSE 16-12 . cytotoxic T cells. All of the following are examples of autoimmune diseases except A. Graves disease. D. E. Wiskott-Aldrich syndrome. myasthenia gravis. Hashimoto thyroiditis. D. B. plasma cells.

tissue from an identical twin is used. The allergen in poison ivy plants is oil called urushiol. the recipient's blood type may change to the blood type of the donor. shock. TRUE 53. cytotoxic T cells of the recipient recognize and respond to foreign class I MHC receptors on the grafted cells. During graft rejection. TRUE 51. and death. TRUE 16-13 . TRUE 50. Systemic anaphylaxis can quickly result in airway blockage. FALSE 52. The practice of delaying the introduction of solid foods has no validity in preventing allergies in children.Chapter 16 . The most common immunoglobulin deficiency is an IgG deficiency. FALSE 54. In an isograft. After a bone marrow transplant. TRUE 55.Disorders in Immunity 49.

rhinitis 62. Food allergies include gastrointestinal symptoms and often hives. allergens 60. Eczema is an autoimmune disorder. FALSE Fill in the Blank Questions 59. A person who is Rh negative will have anti-Rh antibodies in their serum from early infancy. Tissue transplanted from one body site on a patient to a different body site on that patient is called an _____. 16-14 . TRUE 58.Disorders in Immunity 56. Allergic _________ is a seasonal reaction to inhaled pollen or molds. Type I 61. FALSE 57.Chapter 16 . The antigens to which allergic individuals are sensitive are termed _____. Allergic reactions to penicillins are considered a _____ hypersensitivity.

some tissues are immunologically privileged. Tissue Typing 64.Chapter 16 . An _____ is any chronic local allergy. _____ involves determination of donor HLA antigens compared to those of the recipient's tissue. provocative 67. Type III 16-15 .Disorders in Immunity autograft 63. sequestered antigen 65. The _____ dose of an allergen results in signs and symptoms of the allergy. The ___________ theory explains that during embryonic growth. _____ hypersensitivities involve soluble antigen with IgM or IgG forming complexes that can deposit in tissues. atopy 66.

69. and d) two specific examples of each.Disorders in Immunity Short Answer Questions 68. c) two examples of each. c) patient tissues involved. b) tissue damaging mediators. Answers will vary.Chapter 16 . 70. Discuss the proposed theories that attempt to explain the origin of autoimmunity. Compare and contrast local atopies and contact dermatitis with regard to: a) components and events of the immune response. and. 16-16 . Answers will vary. b) chemical mediators and their effects. Answers will vary. Compare and contrast local atopies and systemic anaphylaxis with regard to: a) events of the hypersensitivity.

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