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Appendix C Immune Response and Hypersensitivity
Puncture Wound Multimedia Activity
After completing the Puncture Wound Multimedia Activity, complete the table below. List the four events of the inflammatory response covered in the activity in the order of occurrence. Rewrite the events in your own words, using vocabulary terms from Ch. 2 of the text.
Vascular Events in an Inflammatory Response
Events 1st Surrounding cells leak fluid that affect the blood vessels. The fluid affecting the surrounding blood vessels causes the release of other cells into the tissue. As the wounded part of the body reacts to the germs, certain cells destroy these germs. Simplified description of event Germs from the nail are introduced below the skin. Professional description of event A foreign object has punctured the skin, bacteria gets in and multiplies. Hyperemia causes neutrophils and polymorps to line along the capillary walls and protect the body from microorganisms The tissue that is damaged releases histamines into the body Histamine is causes the blood vessels to expand and allow plasma and neutrophils to move out of the blood vessels and into the damagedtissue. Polymorphs move to the bacteria in the tissue by the chemotaxis and it ingests and destroys bacteria and toxins in the damaged tissue.
Give a brief description and example in your own words for each of the four types of hypersensitivity presented in Ch. 2.
Type of Hypersensitivity Type I: Allergic/Anaphylactic Description This hypersensitivity is triggered by allergen binding to IgE on mast cells, which produce local severe inflammation or systemic severe inflammation. IgM or IgG interacting with foreign cells to cause their destruction. Antigens combine with antibodies,forming immune complexes. Expose to an antigen results in activation of a T-cell-mediated immune response Example A person who is allergic to bee venom could suffer from anaphylactic shock An incompatable blood transfusion. Farmers Lung caused by mold spore inhalation. Contact with poison ivy and organ rejections.
Type II: Cytotoxic/Cytolytic Type III: Immune Complex Type IV: Cell-mediated/Delayed