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PRAKTIKUM KIMIA MEDISINAL (KIM-403)

Nama percobaan : Prediksi Sifat Farmakokinetika dan Toksisitas Obat


Hari/tgl. Percobaan : Rabu, 17 Oktober 2018
Dilaporkan oleh : Elmira Zaida
Nim : 051511133022
Kelas/kelompok : B / 01

1. N-benzoyl-N’-(4-fluorophenyl)thiourea

Sifat Farmakokinetika
absorbsi Caco2 permeability 1.366 log Papp in 10-6 cm/s
Intestinal absorption 89.798 % Absorbed
(human)
Distribusi VDss (human) -0.176 log L/kg
BBB permeability 0.359 log BB
metabolisme CYP2D6 inhibitor NO
CYP3A4 inhibitor N0
Ekskresi Renal OCT2 substrate NO
Total Clearance -0.473 log ml/min/kg
Toksisitas Oral Rat Acute Toxicity 2.092 mo/kg
(LD50)
AMES toxicity N0
Hepatoxicity NO
2. Omeprazole

Sifat Farmakokinetika
Absorbsi Caco2 permeability 1.23 log Papp in 10-6 cm/s
Intestinal absorption 87.077 % Absorbed
(human)
Distribusi VDss (human) -0.637 log L/kg
BBB permeability -0.395 log BB
metabolisme CYP2D6 inhibitor NO
CYP3A4 inhibitor NO
Ekskresi Renal OCT2 substrate YES
Total Clearance 0.973 log ml/min/kg
Toksisitas Oral Rat Acute Toxicity 2.415 mo/kg
(LD50)
AMES toxicity YES
Hepatoxicity YES