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Arctostaphylos uva-ursi, the Herbal Remedy Which

Kills Bladder Cancer Cells in Vitro, Scientists Say

By Kyle J. Norton

Herbal Arctostaphylos uva-ursi may have a potential in the prevention and
treatment of bladder cancer, some scientists suggested.

Bladder cancer is a medical and chronic condition characterized by cell
growth uncontrollably and disorderly in the tissue of the bladder.

Most bladder cancer starts first on the surface of the inner lining tissue of the
bladder. As the cancer progress to the advanced stage, the malignant cells
can infect other healthy tissue through the circulation of blood and fluid.

Bladder cancer that spreads to other parts of the body, such as other organs,
is known as metastatic bladder cancer.

According to the statistic, every year, approximately, over 80,000 adults,
including 62,380 men and 18,810 women in the United States are diagnosed
with bladder cancer, causing the of deaths of 12,520 men and 4,720 women.

The 5-year relative survival rate of all stages of bladder cancer is about
77%. However, the 5-year relative survival rate for people diagnosed with
stage 0 of bladder cancer is about 98%,

The statistic strongly suggested, if bladder cancer is diagnosed in the early
stage, it is treatable.

The exact causes of bladder cancer are unknown. However, the age of 50
and over, men, smoking, long-term exposure to harmful chemicals are
associated with the increased risk of the disease,

Some researchers suggested certain medical conditions such as diabetes,
previous treatment of radiotherapy and chemotherapy and early menopause
are also some of the prevalent risk factors that may increase the early onset
of bladder cancer.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus
Arctostaphylos, belonging to the family Ericaceae, native to northern North
America, Asia, and Europe.

The herb has been used in traditional medicine as diuretic agent and to treat
urinary problems, including bladder infections, kidney infection, kidney
stone, pelvic pain, etc.

The Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil
and resin, hydroquinones tannins, phenolic glycosides and flavonoids.

In the reaffirm of traditional medicine use of herbal Arctostaphylos uva-ursi
for treatment of various types of cancer, researchers at the Chung-Ang
University College of Medicine launched an investigation to examine the
effects of Arbutin, a glycosylated hydroquinone extracted from the bearberry
plant (Arctostaphylos species) on TCCSUP human bladder carcinoma cell.

At the dose at concentrations of < 500 microg/ml, Arbutin did not exhibit
any cytotoxic effects in TCCSUP cells.

In different concentrations that are higher than 500microg/ml, Arbutin
significantly decreased TCCSUP cell proliferation in a time-dependent
manner.

According to the cell cycle analysis, arbutin strongly disrupted the cell cycle
also in a time-dependent manner.

Furthermore, arbutin led to the inactivation of the extracellular signal-
regulated kinase (ERK), which is known to critically regulate cell
proliferation.

The in-depth analysis also found that arbutin markedly increases the
expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1)which
is considered a key mediator of p53-dependent cell cycle arrest and may
play the role of a tumor suppressor.

Where p53, p53, also known as TP53, is a protein which processes a
function in regulating the cell cycle and hence functions as a tumor
suppression.
Dr. Li H, the lead author, after taking into account of co and confounders,
said, " arbutin inhibits TCCSUP cell proliferation via ERK inactivation and
p21 up-regulation".

Abnormal activation of ERK was found to in human cancer due to DNA
mutation and the combination of ERK pathway inhibitors (cytostatic agents)
and conventional anticancer drugs (cytotoxic agents) are the excellent basis
for scientists to develop new chemotherapeutic strategies against cancer.

Taken altogether, Herbal Arctostaphylos uva-ursi contains a high volume of
Arbutin may be considered a functional herb for the prevention and
combined with conventional medicine for treatment of bladder cancer,

However, further data collection large example size and multi-centers
studies performed with human consumption of the whole food or its
bioactive compounds during the course of the disease will be necessary to
complete the picture of herbal Arctostaphylos uva-ursi anti-bladder cancer
possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published online, including worldwide health, ezine
articles, article base, health blogs, self-growth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-
regulation of p21 By Li H, Jeong YM, Kim SY, Kim MK, Kim DS.(PubMed)