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Ginger, The Pungent Spice Which Processes

Anti Colon Cancer Potential

By Kyle J. Norton

Ginger may process certain bioactive compounds with a function to protect our
body against the onset of colon cancer, some scientists found.

Colon cancer is a medical condition characterized by cell growth


irregularly due to the alternation of DNA.

Most cases of primary colon cancer start in the cell on the surface of the inner
lining of the colon. At this stage, most patients do not experience any
symptoms and discomforts.

However, at the advanced stage, the cancerous cells in the colon not only can
travel a distance far away to infect others healthy tissue and organ but also
cause localized severe pain and symptoms as the proliferation of cancer
have suppressed the nearby nerve cells and tissue.

Researchers do not know the exact causes of the disease. But they do know
a history of polyps, ethnicity, high-fat diet and low fiber, the increase in age, the
long-term infection of colon diseases are some of the prevalent risk factors
associated with the onset and progression of colon cancer, according to
epidemiological studies.

Out of that group of risk factors, the increase in age has been under intensified
studies by many scientists.

According to the statistic, colorectal cancer is the third common cancer in the
US. The median age at diagnosis for colon cancer is 68 in men and 72 in
women.

Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly,
in the 39% of colon cancer diagnosed at the localized-stage disease, the five
and ten years survival rate are 90%.

Dr. Elmer E. van Eeghen, the lead scientist in the cancer program at the Zaans
Medisch Centrum, in the concerns of the increase in the age that impact on the
development of colon cancer launched an investigation on the influence of
age and comorbidity on survival and cause of death in a non-selected
population.

In the study "Impact of age and comorbidity on survival in colorectal cancer"


wrote, "Patients with colorectal cancer are often excluded from clinical trials
based on age or a poor performance score" and " In colon cancer patient age
and comorbidity predict survival. This represents possible bias or a reduced
survival benefit of treatment, and is an indication that colon cancer is not the
prognosis defining illness in the majority of patients".

These results furtherly confirm the prognosis of colon cancer in the aging
population. However, most aging population do not develop colon cancer.

Ginger (Zingiber officinale) or ginger root, the second superfood used for
thousands of years by mankind, is the genus Zingiber, belonging to the family
Zingiberaceae, native to Tamil.

The pungent kitchen spice has been used in traditional and Chinese medicine to
treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic,
etc.

With an aim to find a natural ingredient without side effects for the treatment of
colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an
investigation to examine the anti-tumor and anti-inflammation properties of the
crude ginger extract against many types of cancer, including colorectal cancer.

The cells used in the experiment were divided into 4 groups: the first group
represents HT29 cells without treatment, the second and third groups were cells
treated singly with either ginger or Gelam honey, respectively, and the last
group represents cells treated with ginger and Gelam honey combined.

During the experiment, researchers showed that

* Ginger displays a significant effect in the inhibition of colon cancer cells by


blocking the communication of a signal from a receptor on the surface of the
cell to the DNA in the nucleus of the cell and regulating the cell cycle division.
* Ginger the concentration of the IC50 of 5.2 mg/m simulated the early
apoptosis by enhancing the function proteins associated with execution of
cancer cells and

* Decreasing the expression of proteins associated with cancer cells spreading.

Further differentiation of the anti-proliferative effects of ginger efficacy in


enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal
cancer cell line, HCT 116. researchers showed that ginger (IC50 of 3mg/mL) is
more potent than the Gelam honey (IC50 of 75 mg/mL) in inhibiting the
growth of HCT 116 cells.

These results once against suggested ginger extract could potentially


enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

Additionally ginger in the study of cells divided into 4 groups: the first group
represents HT29 cells without treatment, the second and third groups were cells
treated singly with either ginger or Gelam honey, respectively, and the last
group represents cells treated with ginger and Gelam honey combined
researcher found that

Taken altogether, the ginger extract used alone or combined with honey might
process significant and profound effects in reducing the risk of colon cancer
and combined with primary therapy for the treatment of colon cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published online, including worldwide health, ezine
articles, article base, health blogs, self-growth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and
PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2,
Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against
HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ,
Morad NA, Yusof YA. (PubMed)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E.
van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld.
(PMC)