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Honey Protects the Breast Cells integrity Against

the Onset of Breast Cancer

By Kyle J. Norton

Scientists may have found a sweet whole food which processes a strong effect
in the prevention and treatment of breast cancer, according to some studies.

Breast cancer is a medical condition characterized by cell growth irregularly
and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of
the breast tissue before spreading into deeper layers of the breast.

In the early stage, most patients with breast cancer may experience lumps on
the breast or surrounding the breast.

However, breast skin irritation or dimpling, nipple pain, nipple retraction
(turning inward), redness and scaliness that cannot be healed within 3 weeks
are also the signs and symptoms of the breast cancer.

At the later stage, after colonizing most part of the breast, breast cancer cell
may travel a distance far the way to infect other healthy cells and tissue.

In Canada, according to the statistic, 11% of women will develop breast cancer
by the time they reach 90 years of age.

Just about 20% of breast cancers in Canada are diagnosed in women under 50,
while almost 30% are diagnosed in women over 70 years of age.

These result suggested that the most common risk factor to fuel the onset of
breast cancer is the increase in age.

In the concern of the increasing number of studies indicates that the strength
and even direction the association between breast cancer and established risk
factors differ according to the woman's age when she develops the disease, Dr.
Tryggvadóttir L, the lead scientist. according to the result of the study of a
cohort of 80.219 women attending population-based cervical and breast cancer
screening in Iceland, 1120 cases were identified, aged 26-90 years at diagnosis
and 10,537 controls, individually matched to the cases on birth year and age
when attending wrote at the final report, "age at diagnosis should be taken into
account when studying the effects of breast cancer risk factors".

Sadly to let you know that 60% of women who carry the genetic mutation of
gene BRCA1 and 2 have breast cancer developed before the age of 70.

Other risk factors associated with the onset of breast cancer are reproductive
history having a dense breast, personal and family history, previous intake of
drug diethylstilbestrol (DES), previous radiotherapy.

Regardless of all risk factors, women breast self-examinations are still the most
important methods to have breast cancer diagnosed early and increase the years
of survival.

According to the worldwide statistic, the 5 survival rate of the early stage of
breast cancer is 100%.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the
use of white sugar and artificial sweetener by many people.

In finding natural compounds in cancer therapy, researchers at the United Arab
Emirates University conducted an experiment to test the underlying mechanism
and molecular targets of manuka honey (MH) on proliferation, invasiveness,
and angiogenic potential were investigated using two human breast cancer cell
lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive
MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line.

Infection of MH at concentrations of 0.3-1.25% (w/v) induced a dose-
dependent inhibition of the proliferation of MDA-MB-231 and MCF-7, but not
MCF-10A, cells.

At higher concentrations (>2.5%), MH was found to be generally deleterious to
the growth of all three cell lines.

MH induced apoptosis of MDA-MB-231 cells through activation of proteins
associated with the cell death programming and cancer cells apoptosis
correlated with a loss of proteins associated with cancer cell proliferation.
Furthermore, low concentrations of MH (0.03-1.25% w/v) induced a rapid
reduction in tyrosine-phosphorylated STAT3 (pY-STAT3) involved in cell
growth and division in MDA-MB-231 and MCF-7 cells.

The maximum inhibition of pY-STAT3 was observed at 1 h with a loss of >80%
and coincided with decreased interleukin-6 (IL-6) production.

These results suggested manuka honey (MH) inhibits the breast cancer cell
lines through many different mechanisms.

In a total of 50 nulliparous female Sprague-Dawley rats were grouped as
follows: Group 0 (healthy normal rats control), Group 1 (negative control;
untreated rats), Groups 2, 3 and 4 received daily doses of 0.2, 1.0 and 2.0 g/kg
body weight of TH, respectively. The rats in groups 1, 2, 3, 4 were induced with
80 mg/kg of 1-methyl-1-nitrosourea (MNU) to examine the effects of Tualang
honey (TH) against breast cancer.

The TH-treated rats showed a reduction of tumor progression (mean 75.3 days
versus 51.5 days) compared to control.

The incidence (mean 76.6% versus 100%); the multiplicity (mean 2.5 versus 4
tumor masses per rat); the size of tumor mass (mean 0.41 cm versus 1.47 cm [p
< 0.05]) and the weight of the tumor mass (mean 1.22 g versus 3.23 g; [p <
0.05]) also lower in the TH treated rats compared to control.

The grade of breast cancer is lower (I and II) compared to control (Grade III),

The efficacy of TH treatment in reducing the expression of breast cancer was
attributed to the lower anti-apoptotic proteins (E2, ESR1, and Bcl-xL)
expression and a higher pro-apoptotic proteins (Apaf-1 and Caspase-9)
expression at serum and on cancer tissue level.

The breast cancer size breast in the TH-treated groups was smaller mean tumor
size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers
developing in TH-treated groups was also significantly lower.

More importantly, an increasing trend of the apoptotic index (AI) was found in
TH-treated groups with increasing dosage of Tualang Honey compared to
Taken altogether, adding a portion of honey into women diet may have a
potential effect in reducing the risk of breast cancer.

And honey may be considered an adjunct therapy combined with the primary
medicine for the treatment of breast cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published online, including worldwide health, ezine
articles, article base, health blogs, self-growth, best before it's news, the karate
GB daily, etc.,.
by Named 50 of the best health Tweeters Canada - Huffington
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bioscience, ISSN 0975-6299.

(1) The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-
Induced Suppression of Human Breast Cancer Cells by Aryappalli P1, Al-
Qubaisi SS1, Attoub S2, George JA1,3, Arafat K2, Ramadi KB1, Mohamed
YA1, Al-Dhaheri MM1, Al-Sbiei A1, Fernandez-Cabezudo MJ3, Al-Ramadi
BK. (PubMed)
(2) The anti-cancer effects of Tualang honey in modulating breast
carcinogenesis: an experimental animal study by Ahmed S1,2, Othman NH.
(3) Inhibitory effects of Tualang Honey on experimental breast cancer in rats: a
preliminary study by Kadir EA1, Sulaiman SA, Yahya NK, Othman NH.
(4) Breast cancer risk factors and age at diagnosis: an Icelandic cohort study by
Tryggvadóttir L1, Tulinius H, Eyfjord JE, Sigurvinsson T. (PubMed)