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Myocardial Myocardial
Renal
overload and Myocardial fibrosis and
Renal damage dysfunction
renal dysfunction damage remodelling as shown by
as shown by as shown by
as shown by ↑Cystatin C,
↑fibroblast ↑uric acid
↑hs-cTnT ↑Creatinine,
proliferation
↑BUN
and activation
INCREASE
INCREASE
Preload
NT- Afterload
proBNP
N T-p r Congestion Organ damage and
dysfunction
increase Contractility
Inotropes
Increase CO, EF, Perfusion