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Lahore University of Management Sciences

BIO221 –Genetics
(Fall 2018)

Instructor Dr. M .Tariq (lead), Aziz Mithani


Room No. 9-315A & 9-319A
Office Hours TBA, Mon & Tues 9am-10am
Email m.tariq@lums.edu.pk & aziz.mithani@lums.edu.pk
Telephone 8218 & 8397
Secretary/TA TBA
TA Office Hours TBA
Course URL (if any) No

Course Basics
Credit Hours 4
Lecture(s) Nbr of Lec(s) Per Week 2 Duration 2 hrs
Recitation (per week) Nbr of Rec (s) Per 0 Duration 0
Week
Lab (if any ) per week Nbr of Session(s) Per no Duration no
Week
Tutorial (per week) Nbr of Tut(s) Per 1 Duration 50 min
Week

Course Distribution
Core Core course for Biology major students
Elective For any student
Open for Student Category Sophomore Students (Biology)
Closed for Student Category None

COURSE DESCRIPTION
The intellectual framework of this course will introduce students to basic concepts in genetics and epigenetics. Both genetic and
epigenetic inheritance patterns will be introduced with an emphasis how they influence our development. Different modules will
cover classical genetics based on Mendelian laws and gene interactions which explain deviations from Mendel’s laws. In addition,
microbial genetics, human genetics and epigenetics modules will explain how genetic tools may be used to understand inheritance
of traits in different organisms. How genetics has helped us understanding molecular and biochemical pathways of development is
an important subject of this course. Analysis of mutagenic traits at individual as well as population level will also be covered. The
course outline is divided into 9 modules including presentations by the students at the end of course.

COURSE PREREQUISITE(S)

• None

COURSE OBJECTIVES
• To introduce the basic concepts in genetics and epigenetics inheritance patterns and how they influence our
development.
• How monogenic and multigenic traits are analyzed.
• To understand how biological function can be explored using various genetic and epigenetic approaches.
Lahore University of Management Sciences
Learning Outcomes
At the end of course students must be able to understand:
• Inheritance of monogenic and multigenic traits.
• How different genetic pathways may interact and affect development, how genotypes- phenotypes are linked
• How genetic analysis differs among microbes, fruit flies and human.
• Research articles about cutting edge genetic and epigenetic areas of research
Grading Breakup and Policy

Assignment(s): 10% (3-5 Assignments)


Home Work:
Quiz(s): 5% (3-5 Quizzes)
Class Participation:
Attendance:
Exam1: 20%
Exam2: 20%
Exam3: 20%
Exam4: 20%
Presentations: 5%

Examination Detail

Yes/No: Yes
Combine Separate: Combine
Midterm
Duration: 3hours
Exam
Preferred Date:
Exam Specifications:

Yes/No: Yes
Combine Separate: Combine
Final Exam
Duration: 3 hours
Exam Specifications:

COURSE OVERVIEW
Recommended Objectives/
Lecture Topics
Readings Application
Classical genetics: Introduction to genetics
Basic concepts of genetics covering
and epigenetic, Mendelian genetics,
how genes and chromosome were
chromosomal theory of inheritance, Patterns
discovered and how they are inherited
of autosomal and sex chromosome
in next generations. How genotype
1-5 inheritance, test cross, back cross, allele, Chapter 2, 3 4 and 6: Introduction to
can be correlated to phenotype and
(M. Tariq) homozygote , heterozygote dominant trait, genetic Analysis by Griffiths et al.,
how genetic interactions can be
recessive trait, genotype and phenotype,
studied
Genetic Linkage and Chromosome mapping,
Recombination Genotype to phenotype,
complementation, epistasis,
Exam 1
Chapter13 and 14: Introduction to To introduce different type of
Mutagens, mutations, DNA Repair:
6-9 Genetic Analysis by Griffiths et al., Mutagens which are the sole source
Transposons, Types of mutations, molecular
(M. Tariq) of pathogenic mutations and how
basis of mutations, Mechanism of DNA
DNA repair mechanism works to
Repair
proof read these mutations
Microbial Genetics: conjugation, Chapter 5 : Introduction to Genetic
10-13
transformation, transduction and Analysis by Griffiths et al.,
(M. Tariq)
bacteriophage genetics
Exam 2
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Human genetics: Mendelian pedigee patterns, Chapter 3 and 6: An introduction to
How Mendelian traits can be traced
Autosomal and Sex linked patterns of Human Molecular Genetics by Jack J
in humans and how they can be
14-15 inheritance,cytoplasmic inheritance, Pasternak
mapped and studied in humans in
(M. Tariq) Markers(RFLPs, STRs, SNPs etc, Genetic Chapter 2: Introduction to genetic
contrast to model organisms e.g. pea
Mapping of Mendelian characters, Lod score Analysis by Griffiths et al.,
plant and Drosophila melanogaster
Analysis
Epigenetics: Chromatin structure and nuclear Chapter 10: Introduction to Genetic
organization, transcription machinery and Analysis by Griffiths et al.,
To familiarize the students with
chromatin remodeling, euchromatin and
fundamental concepts in the area of
hetrochromatin, position effect variegation,
16-20 epigenetics covering histone
heritable gene silencing chromatin
(M. Tariq) modifications, cell memory and X
modifications and epigenetic informations,
chromosome inactivation which are
non coding RNAs, X chromosome
important in normal development
inactivation, dosage compensation, cellular
memory and imprinting
Exam 3
Chapter 11: Introduction to Genetic Students will be introduced to
Genomics and transgenics: Forward
21-22 Analysis by Griffiths et al., different approaches which can be
genetics, reverse genetics , gene isolation and
(M. Tariq) used to isolate and study gene at the
manipulation
molecular level.
Population genetics: Hardy Weinberg Chapter 19: Introduction to Genetic To get familiarize with Genetic
equilibrium, factors effecting genotypic and Analysis by Griffiths et al., composition of a population and how
23-25
allelic frequency, inbreeding/assortative different factors are involved to
(Aziz Mithani)
meting, mutation Recombination, Migration, maintain the genetic composition of
Selection and Genetic Drift particular population
Chapter 20: Introduction to Genetic What is the difference between
Analysis by Griffiths et al., discontinuous traits which are under
Quantitative genetics: Inheritance of control of genes and continuous
complex traits, causes of variation, continuous traits which are the results of
26-28
verses discontinuous traits, genotype and interaction of environment and genes.
(Aziz Mithani)
phenotype distribution, Heritability, selection, How these traits can be studied and
QTL analysis how multiple genes which are
involved in their development can be
identified.
Exam 4

Textbook(s)/Supplementary Readings
I. Introduction to Genetic Analysis by Griffiths, Wesler, Lewontin, Gelbart, Suzuki, Miller (eighth edition): Photocopies of
selected chapters
II. Chromatin and Gene Regulation: Molecular mechanisms in epigenetics by Brian M. Turner: Photocopies of selected
chapters.
III. Genetics: Analysis of genes and genomes (sixth edition) by Daniel L. Hartl and Elizabeth W. Jones: Photocopies of
selected chapters
IV. Genetics by Monroe W. Strickberger (3rd edition). Photocopies of selected chapters
V. An introduction to Human Molecular Genetics. Jack J Pasternak 2nd Edition.(Selected chapters)