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Aayushi Chatterji
Literature Presentation
Sharma Lab, The Univ. of Oklahoma
February 23, 2019
Classic Prins and Oxidative Prins Reaction
Prins transformation:
R R
q Nucleophile addition PhI(OAc) 2
(PIDA)
HO O
0 °C, 2 min
R R Nu
R R
PhI(OAc) 2
HFIP/DCM
HO O
0 °C, 2 min
R R Cl
R = H 78%
R = Br 86%
Oxidative Prins Process