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Phospholipid

i) Glycerophospholipids
ii) Sphingophospholipid

Function of phospholipids

-Main lipid component of cell membranes (phospholipid bilayer)

-major component of lung surfactant (dipalmitoyl lecithin)

-act as precursor of hormone second messengers

-platelet activating factor

- found in myelin sheath for insulation (Sphingomyelin)

Phospholipid metabolism

Lecithin (Phosphatidyl choline) synthesis

-Synthesized from activated choline and diacylglycerol

-CDP-choline is the activated form of choline

-A phosphate group is transferred from ATP to choline forming phosphocholine

-A cytidyl group is transferred from CTP to phosphocholine forming CDP-choline

-Phosphocholine is transferred from CDP-Choline to diacylglycerol forming lecithin.


Cephalin synthesis

-Synthetic pathway for cephalin is similar to lechitin

-Ethanolamine is activated to CDP-ethanolamine

-CDP-ethanolamine react with diacylglycerol to form cephalin

Phosphatidyl serine synthesis

-Synthesized from CDP-diacylglycerol and serine

-CDP-DIacyglycerol is formed from phosphatidic acid

-CDP-Diacylglycerol react with serine to form phosphatidyl serine