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3/31/2019 Chapter 16 - Homework-2

Chapter 16 - Homework-2
Due: 1:59pm on Monday, March 18, 2019
You will receive no credit for items you complete after the assignment is due. Grading Policy

Microbiology Animation: Cell-Mediated Immunity: Cytotoxic T Cells

Click here to complete this activity.

Then answer the questions.

Part A
What is apoptosis?

ANSWER:

A protein molecule that forms a pore in the membranes of infected cells.

The receptor on a cytotoxic T-cell that recognizes MHC molecules.

The proliferation of cytotoxic T-cells.

The process of programmed cell death.

Correct

Part B
What is the function of the CD8 receptor?
ANSWER:

Produce IL-2

Produce gamma interferon

Activate cytokines

Bind to MHC molecules

Correct

Part C
What is the fate of activated cytotoxic T-cells?
ANSWER:

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3/31/2019 Chapter 16 - Homework-2

They are destroyed via apoptosis.

They can mature and attack infected cells.

Each activated cytotoxic T-cell proliferates, forming a clone of cells specific to the same antigen.

They proliferate into a clone of cells specific to the same antigen; some of these cells then differentiate into long-lived memory T-cells, while
others mature to attack infected cells.

They can differentiate into long-lived memory T-cells.

They are infected by viruses.

Correct

Part D
Which molecule triggers apoptosis?

ANSWER:

MHC

Granzyme

IL-2

Perforin

Gamma-interferon

Correct

Part E
Which event happens first during cytotoxic T-cell activation?

ANSWER:

Secretion of granzymes and perforin

CD8 binds to MHC molecules of infected cells

Production of IL-2 and gamma-interferon receptors

Clonal proliferation

Correct

Microbiology Animation: Cell-Mediated Immunity: Helper T Cells

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3/31/2019 Chapter 16 - Homework-2
Click here to complete this activity.

Then answer the questions.

Part A
Which receptor on the helper T-cell recognizes the specific antigen from an antigen-presenting cell?
ANSWER:

IL-1 Receptors

TCR

IL-2 Receptors

CD4

Correct

Part B
TH2 cells produce cytokines that activate

ANSWER:

B cells.

cytotoxic T-cells.

natural killer cells.

macrophages.

Correct

Part C
Which proteins on the antigen-presenting cell are recognized by the helper T-cell?
ANSWER:

IL-1 receptors

MHC proteins

IL-2 receptors

CD8 receptors

Correct

Part D
When do helper T-cells develop into TH1 or TH2 cells?

ANSWER:

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3/31/2019 Chapter 16 - Homework-2

Immediately after the binding of the CD4 receptor

Before autostimulation

After proliferation into a clonal population

After B cell activation

Correct

Part E
Natural killer cells are activated by

ANSWER:

bacterial cells.

TH1 cells.

antigen-presenting cells.

TH2 cells.

Correct

Microbiology Animation: Cell-Mediated Immunity: Overview

Click here to complete this activity.

Then answer the questions.

Part A
Which type of cell directly attacks infected cells?

ANSWER:

Helper T-cells

Cytotoxic T-cells

Bacterial cells

Cancerous cells

Correct

Part B

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3/31/2019 Chapter 16 - Homework-2
Immune cells that secrete cytokines and activate other immune cells are:

ANSWER:

Invading pathogenic bacteria

Cytotoxic T-cells

Virally infected cells

Abnormal body cells

Helper T-cells

Correct

Part C
HIV directly infects T-cells. Why is this problematic for cell-mediated immunity?

ANSWER:

HIV reprograms these cells to attack the body cells.

HIV causes cytokines to be produced at much higher levels, altering the normal function of the immune system.

HIV transforms the T-cells into cancer cells.

Cytotoxic T-cells begin to attack the virally infected T-cells, reducing the number of T-cells in the body.

Correct

Part D
How do helper T-cells and cytotoxic T-cells work together?

ANSWER:

Helper T-cells produce cytotoxic T-cells.

Cytotoxic T-cells produce cytokines to activate helper T-cells.

Helper T-cells produce cytokines to activate other cells of the immune system.

Cytotoxic T-cells attack abnormal body cells, while helper T-cells attack virally infected cells.

Correct

MicroFlix Activity: Immunology -- Helper T Cell Activation

Can you label and correctly describe the cells and molecules involved in epitope presentation to Helper T cells?
To review the cell activation, watch this MicroFlix animation: Innate Defenses: Dendritic Cells and Epitope Presentation.

Part A - Helper T Cell Activation


Label the components of the activation of a Helper T cell by a dendritic cell.

Hint 1. T Cell components


Remember that the helper T cell has to identify two things: the epitope presented in MHC-II and the MHC molecule itself.

ANSWER:

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3/31/2019 Chapter 16 - Homework-2

Reset Help

Helper T cell

CD4
TCR

Epitope
Dendritic cell

MHC-II

Correct

Score Summary:
Your score on this assignment is 100%.
You received 2 out of a possible total of 2 points.

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