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PHYA 5340 – Clinical Medicine II

Specific Objectives

Following the required reading and lecture, the student should be able to understand and be able
to compare/contrast the following topics.

Motor Neuron Disorders

 Define: Motor unit, EMG, muscle biopsy, nerve biopsy, Charcot-Marie-Tooth (CMT) disease,
acetylcholine, plasmapheresis, thymoma, Multiple Sclerosis (MS), optic neuritis, ataxia,
Lhermitte’s sign, dysesthesia, trigeminal neuralgia, Cerebral Palsy (CP)
 Identify key clinical features associated with a disorder affecting each of the following
o Motor neuron
o Peripheral nerve
o Neuromuscular junction
o Muscle
 Differentiate between ALS vs. Spinal Muscular Atrophy vs. Bell’s Palsy vs. Guillain-Barre
Syndrome vs. Myasthenia Gravis based on the following:
o Etiology
o Epidemiology
o Clinical manifestations
o Laboratory & special test results
o Diagnostic criteria (if applicable)
o General treatment
o General prognosis
 Identify a simple observational distinction between Bell’s Palsy and Stroke; recognize the
neurological explanation for this distinction
 Recognize the main reason why Guillain-Barre Syndrome can be a medical emergency
 Recognize MS epidemiology and etiology
 Identify risk factors for developing MS
 Identify the diagnostic criteria for MS
 Recognize common clinical manifestations associated with MS
 Identify good/bad prognostic indicators for patients with MS
 Recognize diagnostic tests for MS
 Recognize common treatments for MS
 Identify the following regarding Cerebral Palsy:
o Epidemiology
o Etiology
o Clinical manifestation
o Diagnostic testing
o Treatment
o Prognosis
 Recognize the primary differences between ataxic and spastic CP and identify which is most