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Bentuk Sediaan

Inhaler

By:
Amelia Lorensia
TARGET INHALER ...
- BENTUK SEDIAAN -
Macam-macam aerosol:

Metered-dose Dry Powder Jet Ultrasonic


Inhalers (MDI) Inhalers (DPI) Nebulizer Nebulizer
Partikel size:
The single most important device factor
determining the site of aerosol deposition is
particle size.

Devices for delivering therapeutic aerosols


generate particles with aerodynamic diameters
from 0.5 to 35 microns.
In asthma, the
Particles > 10 microns deposit in airways, not
the oropharynx. the alveoli, are
Particles 5-10 microns deposit in the target for
delivery.
the trachea and large bronchi.
articles 1-5 microns in size reach
the lower airways
Particles <0.5 microns act as a
gas and are exhaled.
Metered-dose Inhaler (MDI)
MDI terdiri dari:

Tabung Obat
bertekanan Surfaktan dan/
(canister) atau pelarut

Ruang dilengkapi Propelan cair


dengan corong &
tutup pelindung
Metered-dose Inhaler (MDI)
Metered-dose Inhaler (MDI)
Metered-dose Inhaler (MDI)
Ketika tabung ditekan  metering katup satu arah
dibuka oleh mekanisme pemicu dalam tubuh
aktivator.
Obat disemprotkan dekat pembukaan corong dan
kemudian pasien dapat menghirupnya. Aerosol
terdiri dari droplet-droplet dalam berbagai
diameter.
Ketika obat dihirup, droplet ukuran besar
terdeposisi di mulut, faring, dan laring, sedangkan
droplet dengan ukuran yang lebih kecil dapat
masuk kedalam saluran pernafasan bawah.
(Beaucage dan Nesbittt, 2002)
PRESS & BREATHE MDIs
Θ:
 Difficulty in co-ordinating device
actuation & inhalation
 Oropharyngeal deposition of the
drug
 CFC devices  “cold freon
effect”
(1)
New Design  pMDI
pMDI (Pressurized Metered Dose Inhaler)

breath actuated
inhalers
Cara pakai : Teknik Penggunaan MDI

Remove the
Shake mouthpiece cap
Breathe out

Hold their Actuating the device Slow deep


breath (as inhalation begins) breath
CLEANING YOUR MDI

5. In the morning, 1. Clean your inhaler mouthpiece about once a week


put the canister or as often as recommended by your doctor or
back inside the pharmacist. In addition to your routine cleanings,
mouthpiece and clean your inhaler if little or no medication is
put the cap on sprayed when you activate the inhaler.
the inhaler.
2. Remove the metal canister from the L-shaped plastic
mouthpiece.

3. Rinse only the mouthpiece and cap with warm


running water for about 30 seconds. Do not wash or
put the canister in water.

4. Let the mouthpiece and cap dry overnight.

(2) 12
MDI + SPACER
Breathe Eazy Spacer® AeroChamber® FISIO CHAMBER®

VORTEX®

OPTICHAMBER®

MicroChamber®
Spacer harus dibersihkan sebelum digunakan
terlebih dulu dan kemudian setiap bulan dicuci
dalam air hangat dengan deterjen dapur serta
dikeringkan dengan udara tanpa pembilasan.

Pengeringan dengan kain atau handuk


kertas dapat mengakibatkan muatan
elektrostatik ('statis') di bagian dalam
spacer, yang dapat mengurangi
ketersediaan dosis. Mouth-piece
harus dibersihkan dari deterjen
sebelum digunakan.

Spacer harus ditinjau setiap 6-12 bulan


untuk memeriksa struktur utuh (misalnya
tidak ada retak) dan katup berfungsi.
(National Asthma Council Australia, 2008)
Using
a metered-dose inhaler
with
a spacer

http://www.health.com/health/library/mdp/0,,zm6397,00.html
• Shake the inhaler and remove the inhaler cap. Check the
inhaler instructions to see if you need to prime your inhaler
before you use it. If it needs priming, follow the instructions
on how to prime your inhaler.
• Place the mouthpiece of the inhaler into the spacer.
• Remove the cap from the spacer.
• Hold the inhaler upright with the mouthpiece at the
bottom.
• Tilt your head back slightly and breathe out slowly
and completely.
• Place the spacer's mouthpiece in your mouth.
• Press down on the inhaler to spray one puff of medicine into the spacer and then
start breathing in slowly (press first, then breathe in).
• Hold your breath for 10 seconds, to give the medicine time to settle in your lungs.
• If you need to take a second dose, wait 30 to 60 seconds to allow the inhaler valve to refill.
DPI
(Dry Powder Inhaler)
By:
Amelia lorensia
a) DISKUS® / ACCUHALER®
Langkah-langkah:
1. Buka penutup
2. Geser tuas kebelakang
3. Hembuskan nafas sampai FRC,
menjauh dari Diskus®
4. Hirup dosis
5. Lepaskan Diskus® dari mulut dan
tahan nafas selama 10 detik.
6. Tutup penutup Diskus®
7. Jika dosis lain diperlukan, dapat
mengikuti langkah 1-6.
b) TURBUHALER® / FLEXHALER®
Diagram Turbuhaler
(Adapted with permission from AstraZeneca, Canada.)

(Beaucage dan Nesbittt, 2002)


Teknik Penggunaan
Turbuhaler®
(Adapted from the self-
management program
“Living well with COPD©,
Inhalation Technique Card,
Turbuhaler®.”)

(Beaucage dan Nesbittt, 2002)


HandiHaler®
Nebulizer