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Coe Double-blind Clinical Trial of HD-03/ES versus ~~ I UPros Mort Tel Crier tanrac aerate slants) ABSTRACT Bacgrwnd ire sind D3 utc igen porno sd hei vomit ‘ste Act sade ony saad ae HD 3 eed af gaint icy elongate nd ‘Sere admllcnion i Ths ay ws andre o end ely a ery of oe formation HD IES {Spc he management paces wih hic hp B inecton. Mathode Doble od domed, play ‘Seed cna sy scat ot in 5p with hoc eptea Law hepete Barca HBAS ‘So hepte Be snope eA) ss el asin aneminne ALD aeeacon wees 16and 24 aks ef derapy. Reale Seely sigsieantInproeents were bev ncaa TV asker er ‘iicadon of HD-OMES cape, Avene flee mere mail and eer warated eval ofthe dug Cncsion, ‘Rew cout of HD-ASES and eee in opt mage fae hep Key word: HDA, chon ep B, nl i HB. ALT couch Bs he mot oon i et Hi eee ye Bey vue IBV) th ace et Cs de to ha, cio ae Fite ler The WHO eins th eaten peewee sey orice wh Kips fa 205 ste 1030 talon oe Dene inced with HBV and BY ic nde wo ow tn dent ack Ja Apnaey tre pools de chino fo pa 8 abe hee nope ee ese tatoos walle fr Gove win he doped Son beets 3 (CHD) coe {daly nop grote wen che amet of CHB shuld hve he flloring eres Have pent Smt el aie difeee stes of HBV-DNA tele, excelent fy pile and esl Ines a und pone waned durin of therpy Pen he ig seeps fx CHB have eens wl edocemotbiiy snd ore fo soe inte whe ae homely ined? ‘neat tai ce a, Rnd ‘lf Chi Pi 2, Ob 2010 liaton, HBV-DNA Ayurveda, an indigenous sytem of medicine in Incl, bas «long sradon of twang ler dsonders vwith plane divge? On the bas of leads svable fiom flor unage and recent eperinenal sues, HIDOVES (a capiule formulason conising of 125 mg each of hyroalcohoicexracs ofthe ars peat rons and Cpe earons) was developed 10 lide hepatoprotective tacigen suppresion and HBV elimination of herbal erence contining rounder Sand C reson were examined using to bepasts B turfice angen (HBsAg) expresing human hepao- felblar carcnoma call Hoes, PLCIPRE/S and HepG2.2215. Pelmerse chin reaction (PCR) for seaty of aplication of DNA speci o HBV, reverse Teanecipate inhibison ay, immunomodalaary ‘ees and hepatoprotective ably againe oxidative damage to heputocyes were some of the other stds permed ro vate the efiacy of he pnt exc. The efiacy of the plant exact to lina the DHBV sree amr in spore infeed old docks ina duck model ssa) Our investigation incised tht che exracs could tevershy inhi eell growth tnd suppses HBsAg expreion in bath the Maman Iepstoclludae carcinoma cel line model. Aeste and state tore stiles conducted in rt indicated that HDLOBIES is devoid of sgnieane oxy Following ate and repented admiiersan im ots (Daron fe, 7 268 DOIGINAL ARTICLE A proliminary cave seedy sore Indicated that hace was sgncantreducon o€ HBsAg along with CGsoppeaance of vil DNA in a patent tated ‘veh HD-OSIES at a desge of wo capsules ice dally {br 4 peiod of sx mont! At the moment, ther ie no data to show whether HD-O3ES srentment is ‘equate for che teatment of HBV infection. We therfore, undenook hit clini sudy co evlste the sey and eBeacy of HOES in patens with epi B infeson, Material and Methods Patients with CHB oho anemied the Outpatient Department of Matic, Rajenda Insure of Meicl Scince Bara, Ranchi, India becween August 2003 sd Sepcmer 2004 were enilled in the presot find, Blige paints included males and females ged 18-65 yeas wih positve HBsAg for at least ‘ix month The slnie transaminase (ALT) les of these patients should be within sx mes the upper limi of nom a che screening vst. Paes were cluded If they bad decompensated liver diese (defined by serum slbazin #36 pd brain 23 gl, prothrombin ine 2 second prolonged or Riery of Sch, vail hemorrhage or epic eacephalopthy), pangropenia (ined as hemoglobin