You are on page 1of 27

Database: Embase <1974 to 2019 April 15>

Search Strategy:
--------------------------------------------------------------------------------
1 Cortex elastometer.ti. (0)
2 elastometer.ti. (6)
3 (cortex adj10 skin).mp. (938)
4 cortex.mp. adj5 skin.ti. (432)
5 elasto*.mp. (31817)
6 4 and 5 (3)
7 elast*.mp. (168187)
8 cortex.mp. (471097)
9 7 and 8 (1018)
10 skin/ (148135)
11 exp skin/ (337061)
12 9 and 11 (41)
13 6 or 12 (43)
14 (skin or derm*).mp. [mp=title, abstract, heading word, drug trade name,
original title, device manufacturer, drug manufacturer, device trade name, keyword,
floating subheading word, candidate term word] (1177492)
15 13 and 14 (35)
16 6 or 15 (35)
17 "skin elasticity meter"/ (214)
18 8 and 17 (10)
19 6 or 18 (11)

*************************
1.

Predictive validity of short term scar quality on final burn scar outcome using the
Patient and Observer Scar Assessment Scale in patients with minor to moderate burn
severity.
Goei H., van der Vlies C.H., Tuinebreijer W.E., van Zuijlen P.P.M., Middelkoop E., van
Baar M.E.
Burns. 43 (4) (pp 715-723), 2017. Date of Publication: June 2017.
[Article]
AN: 614094601
Background The aim of this study was to assess the predictive validity of the Patient
and Observer Assessment Scale (POSAS), in order to determine whether it can be
used to predict final scar quality. Methods Patients with a maximum TBSA burned of
20% who were treated in a Dutch burn center and participated in two scar
assessments at 3 months and >18 months post-burn were included. Scar quality
assessment consisted of the POSAS, Dermaspectrometer (color) and Cutometer
(elasticity). Predictive validity was determined in three ways: (1) the discriminative
ability to distinguish good from reduced long term scar quality, (2) correlations
between POSAS items score at the two subsequent assessments and (3) linear
regression was conducted to identify POSAS items as independent predictors.
Additionally, reliability, construct validity and interpretability were assessed. Results
A total of 141 patients were included with a mean TBSA burned of 5.2% (+/-4.5). The
ability of the Patient scale to discriminate between good and reduced long term scar
quality was adequate with an area under the curve (AUC) of 0.728 (CI 0.640-0.804),
the ability of the Observer scale was good with an AUC of 0.854 (CI 0.781-0.911).
Correlations between items scored T3 and T > 18 were at least adequate. On item
level, pain and stiffness (Patient) and pliability and relief (Observer) were identified as
significant predictors for reduced long term scar quality. The POSAS was reliable,
construct validity was adequate at three months but declined at?>18 months.
Conclusion This study found that final scar quality can be adequately predicted by an
early POSAS assessment at three months.
Copyright © 2016 Elsevier Ltd and ISBI
Embase Accession Number
20170048971
PMID
28040371 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28040371]
Status
Embase
Author NameID
van Baar M.E.; ORCID: http://orcid.org/0000-0001-5823-7375
Author Email
van Baar M.E.; baarm@maasstadziekenhuis.nl Goei H.;
goeih@maasstadziekenhuis.nl
van der Vlies C.H.; vliesc@maasstadziekenhuis.nl
Tuinebreijer W.E.; wetuineb@knmg.nl
Middelkoop E.; emiddelkoop@burns.nl
van Zuijlen P.P.M.; paulvanzuijlen@me.com
Institution
(Goei, van Baar) Association of Dutch Burn Centres, Burn Centre Maasstad Hospital,
Rotterdam, Netherlands (Goei, van Zuijlen, Middelkoop) Department of Plastic,
Reconstructive and Hand Surgery, MOVE Research Institute, VU University Medical
Centre, Amsterdam, Netherlands
(van der Vlies) Burn Centre, Maasstad Hospital, Rotterdam, Netherlands
(Tuinebreijer, van Zuijlen, Middelkoop) Association of Dutch Burn Centres, Burn
Centre Red Cross Hospital, Beverwijk, Netherlands
(van Zuijlen) Department of Plastic, Reconstructive and Hand Surgery, Red Cross
Hospital, Beverwijk, Netherlands
Correspondence Address
M.E. van Baar, Burn Centre, Maasstad Hospital, P.O. Box 9100, Rotterdam, AC 3007,
Netherlands. E-mail: baarm@maasstadziekenhuis.nl
Country of Publication
United Kingdom
Publisher
Elsevier Ltd
Journal Translated Name
Burns
Keyword
Burns, Outpatient burn care, POSAS, Predictive validity, PROMs, Scars
URL
http://www.elsevier.com/locate/burns
Emtree Heading
adolescent; adult; aged; article; body surface; burn/su [Surgery]; burn patient; *burn
scar/di [Diagnosis]; child; clinical trial (topic); construct validity; controlled study;
correlation coefficient; diagnostic test accuracy study; discriminant analysis;
erythema; female; follow up; human; independent variable; infant; injury severity;
internal consistency; major clinical study; male; newborn; pain; pliability; *predictive
validity; predictive value; predictor variable; pruritus; reliability; rigidity; skin blood
flow; skin color; skin colorimeter; *skin disease assessment; skin elasticity meter;
skin pigmentation; skinfold thickness; statistical concepts; statistical parameters;
vascularization; wound closure; melanin/ec [Endogenous Compound]; interpretability;
*Patient and Observer Assessment Scale.
Candidate Terms
interpretability [other term]; *Patient and Observer Assessment Scale [other term].
Drug Index Terms

Page 2
melanin / endogenous compound.
Other Index Terms
adolescent; adult; aged; Article; body surface; burn / surgery; burn patient; *burn
scar / *diagnosis; child; clinical trial (topic); construct validity; controlled study;
correlation coefficient; diagnostic test accuracy study; discriminant analysis;
erythema; female; follow up; human; independent variable; infant; injury severity;
internal consistency; major clinical study; male; newborn; pain; pliability; *predictive
validity; predictive value; predictor variable; pruritus; reliability; rigidity; skin blood
flow; skin color; skin colorimeter; *skin disease assessment; skin elasticity meter;
skin pigmentation; skinfold thickness; statistical concepts; statistical parameters;
vascularization; wound closure.
Number of References
31
Embase Section Headings
Dermatology and Venereology [13], Surgery [9]
Device Trade Names and Manufacturers
Courage Khazaka [Germany], Cortex [Denmark], Cutometer Skin Elasticity Meter 575:
Courage Khazaka [Germany], Dermaspectrometer: Cortex [Denmark]
CAS Registry Numbers
8049-97-6 (melanin)
ISSN
0305-4179
Electronic ISSN
1879-1409
DOI
http://dx.doi.org/10.1016/j.burns.2016.10.012
CODEN
BURND
Language
English
Summary Language
English
Grant Information
No: 11.102
Organization: *Nederlandse Brandwonden Stichting*
Grant Abstract
This work was financially supported by the Dutch Burns Foundation grant nr 11.102.
Source Type
Journal
Entry Week
201815
Revised Date
20170516
Date Created
20170516
Year of Publication
2017
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2017 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Page 3
Link to the External Link Resolver:
Article Linker

2.

Exploring the prevalence of skin tears and skin properties related to skin tears in
elderly patients at a long-term medical facility in Japan.
Koyano Y., Nakagami G., Iizaka S., Minematsu T., Noguchi H., Tamai N., Mugita Y.,
Kitamura A., Tabata K., Abe M., Murayama R., Sugama J., Sanada H.
International Wound Journal. 13 (2) (pp 189-197), 2016. Date of Publication: 01 Apr
2016.
[Article]
AN: 53081091
The identification of appropriate skin tear prevention guidelines for the elderly
requires clinicians to focus on local risk factors such as structural alterations of the
epidermis and dermis related to skin tears. The aim of this cross-sectional study is to
explore the prevalence of skin tears and to explore skin properties related to skin
tears in elderly Japanese patients at a long-term medical facility. After doing the
prevalence study, 18 participants with skin tears and 18 without were recruited and
an evaluation of their skin properties using 20-MHz ultrasonography, skin blotting and
also Corneometer CM-825, Skin-pH-meterPH905, VapoMeter, Moisture Meter-D and
CutometerMPA580 was undertaken. A total of 410 patients were examined, the
median age was 87years and 73.2% were women. The prevalence of skin tears was
3.9%, and 50% of skin tears occurred on the dorsal forearm. The changes in skin
properties associated with skin tears included increased low-echogenic pixels (LEP)
by 20-MHz ultrasonography, decreased type IV collagen and matrix
metalloproteinase-2, and increased tumour necrosis factor-alpha by skin blotting. In
conclusion, this study suggests that increased dermal LEP, including solar elastosis,
may represent a risk factor for skin tears; this indicates that skin tear risk factors
might not only represent chronological ageing but also photoageing.
Copyright © 2016 John Wiley & Sons Ltd and Medicalhelplines.com Inc.
Embase Accession Number
2014750858
PMID
24674027 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24674027]
Status
Embase
Author Email
Sanada H.; hsanada-tky@umin.ac.jp
Institution
(Koyano, Nakagami, Iizaka, Minematsu, Tamai, Mugita, Kitamura, Abe, Sanada)
Department of Gerontological Nursing/Wound Care Management, Graduate School of
Medicine, The University of Tokyo, Tokyo, Japan (Noguchi) Department of Life
Support Technology, Graduate School of Medicine, The University of Tokyo, Tokyo,
Japan
(Tabata) Sengi Hospital, Ishikawa, Japan
(Abe) Sapporo Skin Clinic, Hokkaido, Japan
(Murayama) Department of Advanced Nursing Technology, Graduate School of
Medicine, The University of Tokyo, Tokyo, Japan
(Sugama) Wellness Promotion Science Center, Institute of Medical Pharmaceutical
and Health Sciences, Kanazawa University, Ishikawa, Japan

Page 4
Correspondence Address
H. Sanada, Department of Gerontological Nursing/Wound Care Management,
Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo
113-0033, Japan. E-mail: hsanada-tky@umin.ac.jp
Country of Publication
United Kingdom
Publisher
Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com)
Journal Translated Name
International Wound Journal
Keyword
Ageing, Elderly, Skin blotting, Skin properties, Skin tears
URL
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-481X
Emtree Heading
aged; article; case control study; controlled study; cross-sectional study; cutaneous
parameters; elastosis; electrode; female; forearm; human; humidity meter; Japanese
(people); major clinical study; male; nursing home; photoaging; prevalence; priority
journal; skin analysis device; skin elasticity meter; skin hydration meter; *skin injury;
skin water loss; very elderly; collagen type 4/ec [Endogenous Compound]; gelatinase
A/ec [Endogenous Compound]; tumor necrosis factor alpha/ec [Endogenous
Compound]; dermal hydration; skin elasticity; skin ph; stratum corneum hydration.
Candidate Terms
dermal hydration [other term]; skin elasticity [other term]; skin pH [other term];
stratum corneum hydration [other term].
Drug Index Terms
collagen type 4 / endogenous compound; gelatinase A / endogenous compound;
tumor necrosis factor alpha / endogenous compound.
Other Index Terms
aged; Article; case control study; controlled study; cross-sectional study; cutaneous
parameters; elastosis; electrode; female; forearm; human; humidity meter; Japanese
(people); major clinical study; male; nursing home; photoaging; prevalence; priority
journal; skin analysis device; skin elasticity meter; skin hydration meter; *skin injury;
skin water loss; very elderly.
Number of References
45
Embase Section Headings
Dermatology and Venereology [13], Gerontology and Geriatrics [20], Biophysics,
Bioengineering and Medical Instrumentation [27]
Device Trade Names and Manufacturers
Courage Khazaka [Germany], Cortex [Denmark], Corneometer CM-825: Courage
Khazaka [Germany], Cutometer MPA 580: Courage Khazaka [Germany], Dermascan
C: Cortex [Denmark], Skin-pH-meter PH905: Courage Khazaka [Germany], VapoMeter
CAS Registry Numbers
146480-35-5 (gelatinase A)
Enzyme Commission Numbers
EC 3.4.24.24 (gelatinase A).
ISSN
1742-4801
Electronic ISSN
1742-481X
DOI
http://dx.doi.org/10.1111/iwj.12251
Language
English

Page 5
Summary Language
English
Grant Information
No: 23249088
Organization: (JSPS) *Japan Society for the Promotion of Science*
No: 25670990
Organization: (JSPS) *Japan Society for the Promotion of Science*
No: 26670914
Organization: (JSPS) *Japan Society for the Promotion of Science*
Grant Abstract
The authors are thankful for the generous support received from the participants and
staff members of Sengi Hospital, Ishikawa Prefecture, Japan. The authors state no
conflict of interest.
Source Type
Journal
Entry Week
201700
Revised Date
20170518
Date Created
20160411
Year of Publication
2016
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2017 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

3.

Non-invasive objective devices for monitoring the inflammatory, proliferative and


remodelling phases of cutaneous wound healing and skin scarring.
Ud-Din S., Bayat A.
Experimental Dermatology. 25 (8) (pp 579-585), 2016. Date of Publication: 01 Aug
2016.
[Review]
AN: 611413208
Objective evaluation of cutaneous wounds through the use of non-invasive devices is
important for diagnosis, monitoring treatment response and can lead to the
development of improved theranostic strategies. The need for objective monitoring of
wound healing and scar formation is evident as this enables accurate diagnosis,
evaluation and prognosis for clinicians and allows for the standardisation and
validation of methodology for researchers. Therefore, this review provides an
overview of the current application of non-invasive objective technologies for the
assessment of wound healing through the different phases of repair. We propose that

Page 6
cutaneous healing parameters can be split into three core domains: anatomical,
mechanical and physiological. These categories can be further subdivided with
respect to specific phases of healing. There is no single instrument, which can
measure all the parameters of healing simultaneously; thus, it is important to choose
the correct device for the particular healing characteristics being monitored.
However, multiprobe systems, which include a number of devices connected to one
main unit, are useful as they enable multiple measurements of different parameters.
Many of the devices have not been validated against histological examination.
Additionally, some of the instruments have not been evaluated in all wound or scar
types and may not be useful throughout all phases of cutaneous wound healing. In
conclusion, non-invasive objective devices are useful in the assessment of cutaneous
wound healing, as these tools can link the treatment and diagnosis by evaluating
response to treatment and thus could aid as a marker for healing and scar
maturation.
Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Embase Accession Number
20160559099
PMID
27060469 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27060469]
Status
Embase
Author Email
Bayat A.; ardeshir.bayat@manchester.ac.uk
Institution
(Ud-Din, Bayat) Plastic and Reconstructive Surgery Research, Institute of
Inflammation and Repair, University of Manchester, Manchester, United Kingdom
(Ud-Din, Bayat) University Hospital of South Manchester NHS Foundation Trust,
Faculty of Medical and Human Sciences, Manchester Academic Health Science
Centre, University of Manchester, Manchester, United Kingdom
Correspondence Address
A. Bayat, Plastic and Reconstructive Surgery Research, Institute of Inflammation and
Repair, University of Manchester, Manchester, United Kingdom. E-mail:
ardeshir.bayat@manchester.ac.uk
Country of Publication
United Kingdom
Publisher
Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com)
Journal Translated Name
Experimental Dermatology
Keyword
biophysical assessment, objective technologies, quantitative measuring tools, scars,
wound healing
URL
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0625
Emtree Heading
analog digital converter; angiogenesis; cell migration; cell proliferation; clinical
evaluation; confocal microscope; Doppler flowmeter; epithelization; fibroblast;
galvanic skin response sensor; human; humidity meter; *non invasive procedure;
optical coherence tomography device; prognosis; review; *scar formation; sebum
production meter; skin analysis device; skin elasticity meter; skin function; skin
hydration meter; *skin injury; skin pigmentation; spectrophotometer; stereovision
camera; tensile strength; tonometer; treatment response; ultrasound scanner;
validation study; wound contraction.
Other Index Terms

Page 7
analog digital converter; angiogenesis; cell migration; cell proliferation; clinical
evaluation; confocal microscope; Doppler flowmeter; epithelization; fibroblast;
galvanic skin response sensor; human; humidity meter; *non invasive procedure;
optical coherence tomography device; prognosis; Review; *scar formation; sebum
production meter; skin analysis device; skin elasticity meter; skin function; skin
hydration meter; *skin injury; skin pigmentation; spectrophotometer; stereovision
camera; tensile strength; tonometer; treatment response; ultrasound scanner;
validation study; wound contraction.
Number of References
99
Embase Section Headings
Dermatology and Venereology [13], Biophysics, Bioengineering and Medical
Instrumentation [27]
Device Trade Names and Manufacturers
Konica Minolta [China], Courage Khazaka [Germany], Cortex [Denmark], Delfin
[Finland], Astron [United Kingdom], polyu [Hong Kong], Aloka [Japan], Perimed
[Sweden], Lucid [United States], Aloka Echo Camera: Aloka [Japan], BME1428 Burns
Model, Chromameter CR 400: Konica Minolta [China], CorneoMeter CM 825: Courage
Khazaka [Germany], Cutometer: Courage Khazaka [Germany], DermaLab: Courage
Khazaka [Germany], DermaLab elasticity probe: Cortex [Denmark], DermaLab
moisture probe: Cortex [Denmark], DermaScan A: Cortex [Denmark], DermaScan C:
Cortex [Denmark], DSM II ColorMeter: Cortex [Denmark], DUB, Eykona camera,
LifeViz II, Mexameter MX18: Courage Khazaka [Germany], PeriScan PIM 3 laser
Doppler flowmeter: Perimed [Sweden], Sebumeters: Cortex [Denmark], Sebumeters:
Courage Khazaka [Germany], Skicon 200, SkinFibroMeter: Delfin [Finland],
VapoMeter: Delfin [Finland], Vivascope: Lucid [United States], VivoSight
ISSN
0906-6705
Electronic ISSN
1600-0625
DOI
http://dx.doi.org/10.1111/exd.13027
CODEN
EXDEE
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201812
Revised Date
20180312
Date Created
20160811
Year of Publication
2016
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2018 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:

Page 8
Click here for full text options

Link to the External Link Resolver:


Article Linker

4.

Skin characteristics: normative data for elasticity, erythema, melanin, and thickness
at 16 different anatomical locations.
Nedelec B., Forget N.J., Hurtubise T., Cimino S., de Muszka F., Legault A., Liu W.L., de
Oliveira A., Calva V., Correa J.A.
Skin Research and Technology. 22 (3) (pp 263-275), 2016. Date of Publication: 01 Aug
2016.
[Article]
AN: 611188568
Background: The clinical use of non-invasive instrumentation to evaluate skin
characteristics for diagnostic purposes and to evaluate treatment outcomes has
become more prevalent. The purpose of this study was to generate normative data
for skin elasticity, erythema (vascularity), melanin (pigmentation), and thickness
across a broad age range at a wide variety of anatomical locations using the
Cutometer (6 mm probe), Mexameter, and high-frequency ultrasound in a healthy
adult sample. Methods: We measured skin characteristics of 241 healthy participants
who were stratified according to age and gender. Sixteen different anatomical
locations were measured using the Cutometer for maximum skin deformation, gross
elasticity, and biological elasticity, the Mexameter for erythema and melanin, and
high-frequency ultrasound for skin thickness. Standardized measurement procedures
were applied for all participants. Results: The means and standard deviations for each
measured skin characteristic for females and males across five different age groups
(20-29, 30-39, 40-49, 50-59, 60-69, and 70-85 years old) are presented. As previously
described, there were variations in skin characteristics across age groups, anatomical
locations, and between females and males highlighting the need to use site specific,
age and gender matched data when comparing skin characteristics. Conclusion: The
reported data provides normative data stratified by anatomical location, age, and
gender that can be used by clinicians and researchers to objectively determine
whether patients' skin characteristics vary significantly from healthy subjects.
Copyright © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Embase Accession Number
20160515287
PMID
26333046 [http://www.ncbi.nlm.nih.gov/pubmed/?term=26333046]
Status
Embase
Author Email
Nedelec B.; bernadette.nedelec@mcgill.ca
Institution
(Nedelec, Forget, Hurtubise, Cimino, de Muszka, Legault, Liu) School of Physical and
Occupational Therapy, McGill University, Montreal, QC, Canada (Nedelec, de
Oliveira) Centre de recherche, Centre hospitalier de l'Universite de Montreal
(CRCHUM), Montreal, QC, Canada
(Nedelec, de Oliveira, Calva) Hopital de readaptation Villa Medica, Montreal, QC,
Canada

Page 9
(Correa) Department of Mathematics and Statistics, McGill University, Montreal, QC,
Canada
Correspondence Address
B. Nedelec, School of Physical and Occupational Therapy, McGill University, Montreal,
QC, Canada. E-mail: bernadette.nedelec@mcgill.ca
Country of Publication
United Kingdom
Publisher
Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com)
Journal Translated Name
Skin Research and Technology
Keyword
Cutometer, DermaScan C, elasticity, erythema, melanin, Mexameter, normative data,
thickness
URL
http://www3.interscience.wiley.com/journal/118541474/home
Emtree Heading
abdomen; adult; aged; anatomical concepts; arm; article; back; cheek; elasticity;
*erythema; female; forearm; forehead; groups by age; hand; human; leg; male;
middle aged; normal human; normal value; sex difference; shoulder; skin analysis
device; skin blood flow; skin colorimeter; skin elasticity meter; *skin function; skin
pigmentation; *skinfold thickness; thigh; thorax; ultrasound; very elderly; young
adult; *melanin/ec [Endogenous Compound]; high frequency ultrasound; *skin
elasticity.
Candidate Terms
high frequency ultrasound [other term]; *skin elasticity [other term].
Drug Index Terms
*melanin / *endogenous compound.
Other Index Terms
abdomen; adult; aged; anatomical concepts; arm; Article; back; cheek; elasticity;
*erythema; female; forearm; forehead; groups by age; hand; human; leg; male;
middle aged; normal human; normal value; sex difference; shoulder; skin analysis
device; skin blood flow; skin colorimeter; skin elasticity meter; *skin function; skin
pigmentation; *skinfold thickness; thigh; thorax; ultrasound; very elderly; young
adult.
Number of References
55
Embase Section Headings
Dermatology and Venereology [13], Radiology [14], Biophysics, Bioengineering and
Medical Instrumentation [27]
Device Trade Names and Manufacturers
Courage Khazaka [Germany], Cortex [Denmark], Cutometer: Courage Khazaka
[Germany], DermaScan C: Cortex [Denmark], Mexameter: Courage Khazaka
[Germany]
CAS Registry Numbers
8049-97-6 (melanin)
ISSN
0909-752X
Electronic ISSN
1600-0846
DOI
http://dx.doi.org/10.1111/srt.12256
CODEN
SRTEF
Language

Page 10
English
Summary Language
English
Source Type
Journal
Entry Week
201812
Revised Date
20180312
Date Created
20160728
Year of Publication
2016
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2018 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

5.

A sixteen-week monadic clinical study evaluating the effects of a skin care product on
the appearance and condition of mature skin.
Summers J., Grob D., Rice M., Schwartz S., Frumento R., Hodge L., Sondgeroth J.
Journal of the American Academy of Dermatology. Conference: 74th Annual Meeting
of the American Academy of Dermatology. Washington, DC United States. Conference
Publication: (var.pagings). 74 (5 SUPPL. 1) (pp AB25), 2016. Date of Publication: May
2016.
[Conference Abstract]
AN: 72275125
Background: Thin, fragile skin is a common condition in older adults. The condition
can lead to a number of problems, from an aged appearance and a loss of firmness
and elastosis, to tearing and fragility that leads to bruising easily. Mechanistically,
collagen and elastin production slows down as we age, making skin drier, less pliable;
therefore, more prone to wrinkling and scaling. Thus, many older adults become
displeased at the appearance of their skin. Several topical consumer products are
available that claim to improve this process; however, published data is limited.
Methods: This was a sixteen week study evaluating the arms, legs, hands and
decolletage in people over the age of 45 (45-70 yrs). Specific evaluations included
the appearance of skin crepiness, transparency, plumpness, texture/smoothness,
elasticity and firmness (cutometer and expert grading). Instrumental evaluations
included measurements for skin hydration, barrier function dermal thickness and
collagen content. Assessments included expert clinical grading for efficacy and
safety, instrumental evaluations, image analysis and subjective questionnaires. A one
week washout period preceded the treatment period, in which subjects used
standardized support products for all decolletage, leg, arm and hand cleansing. The

Page 11
study product was used by subjects a minimum of two times a day (morning and
evening and as needed on the treatment regions in place of their normal moisturizer)
for 16 weeks of treatment. Results: Thirty five subjects were enrolled and completed
the study, no serious adverse events were reported and all tolerance evaluations
were negative. Visual grading revealed significant improvements for all parameters
at all-time points, with crepiness improving by 25%, 25% and 21% at week 12 for the
regions arms, decolletage and hands, respectively. Similarly, cutometer
instrumentation (firmness/ elasticity, respectively) revealed significant improvements
at week 12 for the regions of arms (64%/91%), decolletage (58%/46%) and hands
(56%/64%). SIAscopy, used to measure collagen content, revealed a 38%, 46% and
56% increase in skin collagen content in the decolletage, hands and arms,
respectively, after 16 weeks of continued use. Ultrasound (Cortex USA 20 MgHz) was
used to measure skin thickness. All three treatment regions showed significant
improvement in skin thickness by week 16 with an average improvement of 13%.
Conclusion: These data support the use of this product in a mature population to
improve multiple visible and tactile skin attributes over 16 weeks of continuous use.
Status
CONFERENCE ABSTRACT
Institution
(Summers, Grob, Rice, Hodge, Sondgeroth) Chattem, Chattanooga, TN, United States
(Schwartz, Frumento) IRSI, Port Chester, NY, United States
Correspondence Address
J. Summers, Chattem, Chattanooga, TN, United States
Conference Start Date
20160304
Conference End Date
20160308
Publisher
Mosby Inc.
Emtree Heading
*human; *clinical study; *skin care; *skin; *American; *dermatology; arm; elasticity;
adult; skinfold thickness; skin elasticity meter; leg; United States; ultrasound;
population; parameters; humidifier; hand washing; consumer; image analysis;
wrinkle; questionnaire; safety; devices; thickness; hydration; elastosis; collagen;
elastin.
Drug Index Terms
collagen; elastin.
Other Index Terms
*human; *clinical study; *skin care; *skin; *American; *dermatology; arm; elasticity;
adult; skinfold thickness; skin elasticity meter; leg; United States; ultrasound;
population; parameters; humidifier; hand washing; consumer; image analysis;
wrinkle; questionnaire; safety; devices; thickness; hydration; elastosis.
ISSN
0190-9622
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201600
Date Delivered
20160520
Date Created

Page 12
20160512
Year of Publication
2016
Copyright
Copyright 2016 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

6.

A 16-week single blind trial evaluating the efficacy of a topical product on skin
parameters on older subjects with thin/fragile skin.
Schwartz S., McCraw T., Frumento R.
Journal of the American Academy of Dermatology. Conference: 73rd Annual Meeting
of the American Academy of Dermatology. San Francisco, CA United States.
Conference Publication: (var.pagings). 72 (5 SUPPL. 1) (pp AB12), 2015. Date of
Publication: May 2015.
[Conference Abstract]
AN: 71894814
Background: Thin, fragile skin is a common condition in older adults. The condition
can lead to a number of problems, from an aged appearance and a loss of firmness
and elasticity to tearing and sensitivity that leads to easy bruising. Mechanistically,
collagen and elastin production slows down as we age, making skin drier and less
pliable and skin is therefore more prone to wrinkling and scaling, many older adults
become upset at the appearance of their skin. Several topical consumer products are
available that claim to improve this process, however published data is limited.
Methods: This was a 16-week monadic evaluation of one facial skin treatment serum.
One test product was used with a standardized supporting moisture product on a
panel of forty-eight subjects prequalified as having thin/fragile skin. Instrumental
assessments including Cutometer (MPA 580; Courage+Khazaka, Cologne Germany),
Ultrasound (DermaScan C; Cortex Technology, Hadsund, Denmark), Clarity Image
Analysis (BTBP, San Jose, CA), and SIAscope (MedX; Mississauga, ON, Canada) were
performed at visits on weeks 0, 4, 8, 12, and 16. Data from these assessments were
utilized for analysis of intended product efficacy. Results: Subject demographics are
shown in Table I. The average age of subjects enrolled was 57.62 years. Cutometer
results showed early improvements after 4 weeks of use in firmness and elasticity
(51.55% and 49.47% improvement, respectively), subjects having these
improvements steadily increased throughout the trial. SIAscope collagen data (Table
II) showed significant improvements after 12 and 16 weeks of use. Ultrasound data,
similarly, showed significant improvements in skin thickness after 12 and 16 weeks of
use, echogenicity were numerically improved. Clarity image analysis showed
significant improvements in total lines/ wrinkles, fine line wrinkles, deep line wrinkles,
and the average length and width of wrinkles and in both the crow's feet region and
globally after 16 weeks of product use. Conclusions: Under the conditions employed
in this study, use of this topical facial skin product daily for sixteen weeks led to
measurable improvements in the appearance of facial skin (firmness, elasticity and

Page 13
lines/wrinkles) as well as mechanical properties (skin thickness, collagen) in an aged
population of males and females.
Status
CONFERENCE ABSTRACT
Institution
(Schwartz) International Research Services, Inc, Port Chester, NY, United States
(McCraw) Kimberly Clarke Corporation, Roswell, GA, United States
(Frumento) Port ChesterNYUnited States
Correspondence Address
S. Schwartz, International Research Services, Inc, Port Chester, NY, United States
Conference Start Date
20150320
Conference End Date
20150324
Publisher
Mosby Inc.
Emtree Heading
*skin; *parameters; *American; *dermatology; *single blind procedure; human;
wrinkle; elasticity; adult; image analysis; ultrasound; skin elasticity meter; skinfold
thickness; moisture; population; serum; Canada; consumer; Denmark; technology;
Germany; crow; male; female; courage; collagen; elastin.
Drug Index Terms
collagen; elastin.
Other Index Terms
*skin; *parameters; *American; *dermatology; *single blind procedure; human;
wrinkle; elasticity; adult; image analysis; ultrasound; skin elasticity meter; skinfold
thickness; moisture; population; serum; Canada; consumer; Denmark; technology;
Germany; crow; male; female; courage.
ISSN
0190-9622
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201500
Date Delivered
20150605
Date Created
20150528
Year of Publication
2015
Copyright
Copyright 2015 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

Page 14
7.

Integrative analysis of cutaneous skin tumours using ultrasonogaphic criteria.


Preliminary results.
Crisan D., Badea A.F., Crisan M., Rastian I., Solovastru L.G., Badea R.
Medical Ultrasonography. 16 (4) (pp 285-290), 2014. Date of Publication: 2014.
[Article]
AN: 600461596
The aim of this study is to identify the US features of skin tumors, especially
morphological and vascular, in order to develop an integrative and differentiating
imaging model for benign and malignant skin tumors. Material and method: Twenty
three patients with solid skin tumors were included in the study. The diagnostic
procedures were clinical examination, dermoscopy, multimodal ultrasonography (US),
using high frequency and conventional US, contact elastography, and i.v. contrast
enhanced ultrasound (CEUS). Results: The US characteristics of the basal cell
carcinomas were: hypoechoic, inhomogeneous masses, with hyperechoic or anechoic
areas, depending on the histological differentiation, increased rigidity, uneven
vascularization at Doppler examination, central or mixed type circulatory model, with
1-2 supply vessels, velocity >2 cm/s, intensely inhomogeneous load of the contrast
agent ( CA) and quick wash out time. The benign tumors were hypoechoic or echoic
masses, with inhomogeneous structure, Doppler signal present only in
dermofibromas, peripheral circulation model, velocities < 2.00 cm/s, a weak and
uneven loading of the CA in the vascular bed, and a slow wash out time. Analysis of
the CA dynamics evidenced a significantly higher value for the wash out time in the
malignant tumors (38.2s+/- 15.15) as compared to the benign ones (54.2s +/- 8.5).
Particularly the tumor thickness examination by HFUS evidences an ultrasound index
that may be considered as a statistically significant predictive factor (p<0.05), highly
sensitive (r =0.97) for the non-invasive assessment of the histological Breslow index.
Elastography did not represent a differentiation examination in the cases studied.
Conclusions: Ultrasound allows a complex, multimodal approach of skin tumors,
which completes clinical and histological examinations, orients the therapeutic
management and may assessthe therapeutic efficacy and the tumoral prognosis.
Embase Accession Number
2014904870
PMID
25463879 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25463879]
Status
Embase
Author Email
Crisan M.; maria.crisan@umfcluj.ro
Institution
(Crisan, Crisan, Rastian) Dermatology Department, Clinical Municipal Hospital, Cluj-
Napoca, Romania (Badea) Department of Maxilofacial Surgery, 'Iuliu Hatieganu'
University of Medicine and Pharmacy, Cluj-Napoca, Romania
(Solovastru) Dermatology Department, 'Gr. T. Popa' University of Medicine and
Pharmacy, Iasi, Romania
(Badea) Department of Ultrasonography, 'O. Fodor' Institute of Gastroenterology and
Hepatology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca,
Romania
Correspondence Address
M. Crisan, Dermatology Clinic, Iuliu Hatieganu University of Medicine and Pharmacy,
3-5 Clinicilor Street, Cluj-Napoca 400359, Romania
Country of Publication

Page 15
Romania
Publisher
Societatea Romana de Ultrasonografie in Medicina si Biologie (E-mail:
dfodor@ymail.com)
Journal Translated Name
Medical Ultrasonography
Keyword
Contrast agent, Elastography, Skin, Skin tumors, Ultrasonography
URL
http://www.medultrason.ro/assets/Magazines/Medultrason-2014-vol16-no4/02-
Crisan.pdf
Emtree Heading
actinic keratosis/di [Diagnosis]; adult; aged; article; basal cell carcinoma/di
[Diagnosis]; clinical article; clinical examination; contrast enhancement; controlled
study; Doppler flowmetry; *echography; elastography; epiluminescence microscopy;
female; histopathology; human; keratoacanthoma/di [Diagnosis]; keratosis/di
[Diagnosis]; male; multimodal imaging; non invasive measurement; predictive value;
prospective study; sensitivity analysis; *skin tumor/di [Diagnosis]; tumor
differentiation; tumor vascularization; ultrasound scanner; contrast enhanced
ultrasound; dermofibroma/di [Diagnosis]; high frequency ultrasound.
Candidate Terms
contrast enhanced ultrasound [other term]; dermofibroma / diagnosis [other term];
high frequency ultrasound [other term].
Other Index Terms
actinic keratosis / diagnosis; adult; aged; Article; basal cell carcinoma / diagnosis;
clinical article; clinical examination; contrast enhancement; controlled study; Doppler
flowmetry; *echography; elastography; epiluminescence microscopy; female;
histopathology; human; keratoacanthoma / diagnosis; keratosis / diagnosis; male;
multimodal imaging; non invasive measurement; predictive value; prospective study;
sensitivity analysis; *skin tumor / *diagnosis; tumor differentiation; tumor
vascularization; ultrasound scanner.
Number of References
27
Embase Section Headings
Dermatology and Venereology [13], Radiology [14], Cancer [16], Biophysics,
Bioengineering and Medical Instrumentation [27], Drug Literature Index [37]
Drug Trade Names and Manufacturers
Bracco [Italy], sonovue: Bracco [Italy]
Device Trade Names and Manufacturers
Cortex [Denmark], Phillips [Netherlands], Dermascan: Cortex [Denmark], iU22:
Phillips [Netherlands]
ISSN
1844-4172
Electronic ISSN
2066-8643
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201812
Revised Date
20180312

Page 16
Date Created
20141125
Year of Publication
2014
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2018 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

8.

Skin findings in Williams syndrome.


Kozel B.A., Bayliss S.J., Berk D.R., Waxler J.L., Knutsen R.H., Danback J.R., Pober B.R.
American Journal of Medical Genetics, Part A. 164 (9) (pp 2217-2225), 2014. Date of
Publication: September 2014.
[Article]
AN: 53190863
Previous examination in a small number of individuals with Williams syndrome (also
referred to as Williams-Beuren syndrome) has shown subtly softer skin and reduced
deposition of elastin, an elastic matrix protein important in tissue recoil. No
quantitative information about skin elasticity in individuals with Williams syndrome is
available; nor has there been a complete report of dermatologic findings in this
population. To fill this knowledge gap, 94 patients with Williams syndrome aged 7-50
years were recruited as part of the skin and vascular elasticity (WS-SAVE) study. They
underwent either a clinical dermatologic assessment by trained dermatologists (2010
WSA family meeting) or measurement of biomechanical properties of the skin with
the DermaLabTM suction cup (2012 WSA family meeting). Clinical assessment
confirmed that soft skin is common in this population (83%), as is premature graying
of the hair (80% of those 20 years or older), while wrinkles (92%), and abnormal
scarring (33%) were detected in larger than expected proportions. Biomechanical
studies detected statistically significant differences in dP (the pressure required to lift
the skin), dT (the time required to raise the skin through a prescribed gradient), VE
(viscoelasticity), and E (Young's modulus) relative to matched controls. The RT
(retraction time) also trended longer but was not significant. The biomechanical
differences noted in these patients did not correlate with the presence of vascular
defects also attributable to elastin insufficiency (vascular stiffness, hypertension, and
arterial stenosis) suggesting the presence of tissue specific modifiers that modulate
the impact of elastin insufficiency in each tissue. © 2014 Wiley Periodicals, Inc.
Embase Accession Number
2014539559
PMID
24920525 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24920525]
Status
Embase
Author Email

Page 17
Kozel B.A.; Kozel_b@kids.wustl.edu
Institution
(Kozel) Department of Pediatrics, Washington University School of Medicine, St Louis,
MO, United States (Bayliss, Berk, Danback) Department of Dermatology, Washington
University School of Medicine, St Louis, MO, United States
(Waxler, Pober) Department of Pediatrics, Massachusetts General Hospital, Boston,
MA, United States
(Knutsen) Department of Cell Biology and Physiology, Washington University School
of Medicine, St Louis, MO, United States
(Pober) Department of Medical Sciences, Frank Netter School of Medicine, Hamden,
CT, United States
Correspondence Address
B.A. Kozel, Washington University School of Medicine, 660 S. Euclid, Campus Box
8208, St. Louis, MO 63110, United States. E-mail: Kozel_b@kids.wustl.edu
Country of Publication
United States
Publisher
Wiley-Liss Inc. (E-mail: info@wiley.com)
Journal Translated Name
American Journal of Medical Genetics, Part A
Keyword
Biomechanics, Elastin, Graying of hair, Skin, Skin wrinkling, Williams syndrome
URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4833
Emtree Heading
adult; article; biomechanics; child; clinical assessment; controlled study; cutaneous
parameters; dermatologist; disease association; female; hair discoloration; human;
major clinical study; male; middle aged; priority journal; scar formation; school child;
skin elasticity meter; skin examination; skin manifestation; vascular disease;
viscoelasticity; *Williams Beuren syndrome; wrinkle; Young modulus; elastin/ec
[Endogenous Compound]; skin elasticity; skin retraction time.
Candidate Terms
skin elasticity [other term]; skin retraction time [other term].
Drug Index Terms
elastin / endogenous compound.
Other Index Terms
adult; article; biomechanics; child; clinical assessment; controlled study; cutaneous
parameters; dermatologist; disease association; female; hair discoloration; human;
major clinical study; male; middle aged; priority journal; scar formation; school child;
skin elasticity meter; skin examination; skin manifestation; vascular disease;
viscoelasticity; *Williams Beuren syndrome; wrinkle; Young modulus.
Number of References
38
Embase Section Headings
Dermatology and Venereology [13], Biophysics, Bioengineering and Medical
Instrumentation [27], Neurology and Neurosurgery [8]
Device Trade Names and Manufacturers
Cortex [Denmark], DermaLab: Cortex [Denmark]
CAS Registry Numbers
9007-58-3 (elastin)
ISSN
1552-4825
Electronic ISSN
1552-4833
DOI

Page 18
http://dx.doi.org/10.1002/ajmg.a.36628
CODEN
AJMGD
Language
English
Summary Language
English
Grant Information
No: K12-HD01487
Organization: (NIH) *National Institutes of Health*
No: K12-HL089968
Organization: (NIH) *National Institutes of Health*
Source Type
Journal
Entry Week
201700
Revised Date
20161223
Date Created
20140820
Year of Publication
2014
Indexing Status
Enhancement type="8" status="002"
Copyright
Copyright 2016 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

9.

Pentacyclic triterpenes from terminalia arjuna show multiple benefits on aged and dry
skin.
Farwick M., Kohler T., Schild J., Mentel M., Maczkiewitz U., Pagani V., Bonfigli A.,
Rigano L., Bureik D., Gauglitz G.G.
Skin Pharmacology and Physiology. 27 (2) (pp 71-81), 2014. Date of Publication: 20
Apr 2014.
[Article]
AN: 603908094
Background: Pentacyclic triterpenoids improve epidermal barrier function and induce
collagen production. Here, their effects on cutaneous aging by means of objective
instrumental measurements were elucidated. Methods: Reconstituted human
epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia
arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of
various genes was determined using microarray analysis, qRT-PCR and ELISA
techniques. Clinical efficacy of T. arjuna bark extract versus vehicle control cream
was elucidated in 30 patients and transepidermal water loss (TEWL), skin hydration

Page 19
and elasticity were measured. Another 30 female patients in their postmenopausal
phase were treated with a similar regime, and skin sebum content, cutaneous blood
microcirculation and skin density/echogenicity were assessed. Results: Incubation
with T. arjuna triterpenes increased FGF-2, TSP-1, TGF-beta and CTGF expression, and
VEGF secretion in vitro. Elevated lactate dehydrogenase release upon sodium
dodecyl sulphate challenge was reversed by the application of T. arjuna bark extract.
T. arjuna bark extract decreased TEWL, improved skin moisturization, reduced
scaliness and led to significantly improved skin elasticity. Also, increases in blood
microflow and skin sebum content as well as improved skin thickness/echogenicity
were noted on postmenopausal skin, resulting in visible reduction of sagging skin on
the jowls as demonstrated by digital photography. Conclusion:T. arjuna bark extract
appears as an innovative active ingredient that exerts versatile antiaging properties
in vitro and in vivo.
Copyright © 2013 S. Karger AG, Basel.
Embase Accession Number
2015945523
PMID
24008587 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24008587]
Status
Embase
Author Email
Gauglitz G.G.; Gerd.Gauglitz@med.uni-muenchen.de
Institution
(Farwick, Kohler, Schild, Mentel, Maczkiewitz) Evonik Industries AG, Essen, Germany
(Bureik, Gauglitz) Department of Dermatology and Allergology, Ludwig Maximilians
University, Frauenlobstrasse 9-11, Munich DE-80337, Germany
(Pagani, Bonfigli, Rigano) Institute of Skin and Product Evaluation (ISPE), Milan, Italy
Country of Publication
Switzerland
Publisher
S. Karger AG
Journal Translated Name
Skin Pharmacology and Physiology
Keyword
Antiaging properties, Arjunolic acid, Skin blood microcirculation, Skin penetration,
Triterpenes
URL
http://www.karger.com/spp
Emtree Heading
adult; aged; *aging; animal tissue; article; clinical article; controlled study; cutaneous
parameters; density; *drug activity; drug bioavailability; drug efficacy; drug
penetration; *dry skin/dt [Drug Therapy]; dry skin/dt [Drug Therapy]; enzyme linked
immunosorbent assay; epidermis; female; gene expression; human; human cell;
human tissue; in vitro study; keratinocyte; microarray analysis; microcirculation;
nonhuman; postmenopause; priority journal; protein expression; protein secretion;
real time polymerase chain reaction; sebum production meter; sebum secretion; skin
absorption; skin analysis device; skin blood flow; skin elasticity meter; skin fibroblast;
skin hydration meter; skin penetration; skin water loss; skinfold thickness; *Terminalia
arjuna; ultrasound scanner; Centella asiatica extract/cm [Drug Comparison]; Centella
asiatica extract/dt [Drug Therapy]; connective tissue growth factor/ec [Endogenous
Compound]; *cosmetic/cm [Drug Comparison]; *cosmetic/dv [Drug Development];
*cosmetic/dt [Drug Therapy]; *cosmetic/pr [Pharmaceutics]; *cosmetic/pk
[Pharmacokinetics]; *cosmetic/pd [Pharmacology]; dodecyl sulfate sodium; fibroblast
growth factor 2/ec [Endogenous Compound]; isoflavone derivative/cm [Drug
Comparison]; isoflavone derivative/dt [Drug Therapy]; lactate dehydrogenase/ec

Page 20
[Endogenous Compound]; messenger RNA/ec [Endogenous Compound]; *pentacyclic
triterpene/cm [Drug Comparison]; *pentacyclic triterpene/dv [Drug Development];
*pentacyclic triterpene/dt [Drug Therapy]; *pentacyclic triterpene/pr [Pharmaceutics];
*pentacyclic triterpene/pk [Pharmacokinetics]; *pentacyclic triterpene/pd
[Pharmacology]; *Terminalia arjuna extract/cm [Drug Comparison]; *Terminalia arjuna
extract/dv [Drug Development]; *Terminalia arjuna extract/dt [Drug Therapy];
*Terminalia arjuna extract/pr [Pharmaceutics]; *Terminalia arjuna extract/pk
[Pharmacokinetics]; *Terminalia arjuna extract/pd [Pharmacology]; thrombospondin
1/ec [Endogenous Compound]; transforming growth factor beta/ec [Endogenous
Compound]; unclassified drug; vasculotropin/ec [Endogenous Compound]; *antiaging
activity; skin density; soy isoflavone/cm [Drug Comparison]; soy isoflavone/dt [Drug
Therapy]; *tego arjuna s/cm [Drug Comparison]; *tego arjuna s/dv [Drug
Development]; *tego arjuna s/dt [Drug Therapy]; *tego arjuna s/pr [Pharmaceutics];
*tego arjuna s/pk [Pharmacokinetics]; *tego arjuna s/pd [Pharmacology].
Candidate Terms
*antiaging activity [other term]; skin density [other term]; soy isoflavone / drug
comparison / drug therapy [drug term]; *tego arjuna s / *drug comparison / *drug
development / *drug therapy / *pharmaceutics / *pharmacokinetics / *pharmacology
[drug term].
Drug Index Terms
Centella asiatica extract / drug comparison / drug therapy; connective tissue growth
factor / endogenous compound; *cosmetic / *drug comparison / *drug development /
*drug therapy / *pharmaceutics / *pharmacokinetics / *pharmacology; dodecyl sulfate
sodium; fibroblast growth factor 2 / endogenous compound; isoflavone derivative /
drug comparison / drug therapy; lactate dehydrogenase / endogenous compound;
messenger RNA / endogenous compound; *pentacyclic triterpene / *drug
comparison / *drug development / *drug therapy / *pharmaceutics /
*pharmacokinetics / *pharmacology; *Terminalia arjuna extract / *drug comparison /
*drug development / *drug therapy / *pharmaceutics / *pharmacokinetics /
*pharmacology; thrombospondin 1 / endogenous compound; transforming growth
factor beta / endogenous compound; unclassified drug; vasculotropin / endogenous
compound.
Other Index Terms
adult; aged; *aging; animal tissue; Article; clinical article; controlled study; cutaneous
parameters; density; *drug activity; drug bioavailability; drug efficacy; drug
penetration; *dry skin / *drug therapy; dry skin / drug therapy; enzyme linked
immunosorbent assay; epidermis; female; gene expression; human; human cell;
human tissue; in vitro study; keratinocyte; microarray analysis; microcirculation;
nonhuman; postmenopause; priority journal; protein expression; protein secretion;
real time polymerase chain reaction; sebum production meter; sebum secretion; skin
absorption; skin analysis device; skin blood flow; skin elasticity meter; skin fibroblast;
skin hydration meter; skin penetration; skin water loss; skinfold thickness; *Terminalia
arjuna; ultrasound scanner.
Triple Subheading
dry skin / drug therapy / Centella asiatica extract; dry skin / drug therapy / cosmetic;
dry skin / drug therapy / isoflavone derivative; dry skin / drug therapy / pentacyclic
triterpene; dry skin / drug therapy / soy isoflavone; dry skin / drug therapy / tego
arjuna s; dry skin / drug therapy / Terminalia arjuna extract; Centella asiatica extract /
drug comparison / cosmetic; Centella asiatica extract / drug comparison / pentacyclic
triterpene; Centella asiatica extract / drug comparison / tego arjuna s; Centella
asiatica extract / drug comparison / Terminalia arjuna extract; Centella asiatica
extract / drug therapy / dry skin; cosmetic / drug comparison / Centella asiatica
extract; cosmetic / drug comparison / isoflavone derivative; cosmetic / drug
comparison / soy isoflavone; cosmetic / drug therapy / dry skin; isoflavone
derivative / drug comparison / cosmetic; isoflavone derivative / drug comparison /

Page 21
pentacyclic triterpene; isoflavone derivative / drug comparison / tego arjuna s;
isoflavone derivative / drug comparison / Terminalia arjuna extract; isoflavone
derivative / drug therapy / dry skin; pentacyclic triterpene / drug comparison /
Centella asiatica extract; pentacyclic triterpene / drug comparison / isoflavone
derivative; pentacyclic triterpene / drug comparison / soy isoflavone; pentacyclic
triterpene / drug therapy / dry skin; soy isoflavone / drug comparison / cosmetic; soy
isoflavone / drug comparison / pentacyclic triterpene; soy isoflavone / drug
comparison / tego arjuna s; soy isoflavone / drug comparison / Terminalia arjuna
extract; soy isoflavone / drug therapy / dry skin; tego arjuna s / drug comparison /
Centella asiatica extract; tego arjuna s / drug comparison / isoflavone derivative; tego
arjuna s / drug comparison / soy isoflavone; tego arjuna s / drug therapy / dry skin;
Terminalia arjuna extract / drug comparison / Centella asiatica extract; Terminalia
arjuna extract / drug comparison / isoflavone derivative; Terminalia arjuna extract /
drug comparison / soy isoflavone; Terminalia arjuna extract / drug therapy / dry skin.
Number of References
35
Embase Section Headings
Dermatology and Venereology [13], Biophysics, Bioengineering and Medical
Instrumentation [27], Clinical and Experimental Pharmacology [30], Drug Literature
Index [37], Pharmacy [39]
Drug Trade Names and Manufacturers
tego arjuna s
Device Trade Names and Manufacturers
Cortex [Denmark], Courage Khazaka, Courage Khazaka [Germany], Corneometer CM
825: Courage Khazaka [Germany], Cutometer MPA 580: Courage Khazaka,
Dermascan C: Cortex [Denmark], Sebumeter SM 810: Courage Khazaka
CAS Registry Numbers
151-21-3 (dodecyl sulfate sodium); 106096-93-9 (fibroblast growth factor 2); 9001-
60-9 (lactate dehydrogenase); 343987-56-4 (thrombospondin 1); 127464-60-2
(vasculotropin)
Enzyme Commission Numbers
EC 1.1.1.27 (lactate dehydrogenase).
ISSN
1660-5527
Electronic ISSN
1660-5535
DOI
http://dx.doi.org/10.1159/000351387
CODEN
SPPKC
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201500
Revised Date
20150507
Date Created
20150507
Year of Publication
2014
Copyright

Page 22
Copyright 2015 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

10.

Longitudinal burn scar quantification.


Nedelec B., Correa J.A., De Oliveira A., LaSalle L., Perrault I.
Burns. 40 (8) (pp 1504-1512), 2014. Date of Publication: 01 Dec 2014.
[Article]
AN: 53081406
Quantitative studies of the clinical recovery of burn scars are currently lacking.
Previous reports validate the objective, precise, diagnostic capabilities of high-
frequency ultrasound to measure thickness, the Cutometer to measure pliability and
the Mexameter to measure erythema and pigmentation of scars. Thus, we
prospectively quantified clinical characteristics of patient-matched, after burn
hypertrophic scar (HSc), donor site scar (D) and normal skin (N) using these
instruments. One investigator measured 3 sites (HSc, D, N) in 46 burn survivors at 3,
6, and 12 months after-burn. A mixed model regression analysis, adjusting p-values
for multiplicity of testing, was used to compare means among sites and time points.
Participants were 41.2 +/- 13.5 years old, 87% males, predominantly Caucasian, with
an average of 19.5% body surface area burned. HSc thickness decreased significantly
between 3 and 6, 6 and 12, and 3 and 12 months (all p < 0.0001), but remained
thicker than D and N skin (all p < 0.0001). Pliability differed significantly between
HSc, D and N sites at all time points (all p < 0.0001), with HSc and D increasing
between 3 and 12 months (p < 0.05) but not reaching normal. HSc and D sites were
significantly more erythematous than normal skin (p < 0.05) at 3 and 6 months but D
sites approached normal by 12 months. The only time points at which pigmentation
significantly differed were the HSc and D sites at 6 months. Thickness, pliability,
erythema and pigmentation of N skin remained similar over the 12 months. We found
that post-burn HSc thickness, pliability and erythema differed significantly from D and
N skin at 3, 6, and 12 months and does not return to normal by 12 months after-
injury; however, significant improvements towards normal can be expected. Donor
sites are redder than normal skin at 3 and 6 months but can be expected to return to
normal by 12 months. Although the color of HSc and D sites change markedly with
time these color changes are primarily due to changes in redness of the site, not
melanin in this primarily Caucasian population.
Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.
Embase Accession Number
2014704429
PMID
24703337 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24703337]
Status
Embase
Author Email
Nedelec B.; bernadette.nedelec@mcgill.ca
Institution

Page 23
(Nedelec) School of Physical and Occupational Therapy, McGill University, Canada
(Nedelec, De Oliveira, Perrault) Centre de Recherche du Centre Hospitalier de
l'Universite de Montreal (CHUM), Canada
(Nedelec, De Oliveira, LaSalle) Hopital de Readaptation Villa Medica, Canada
(Correa) Department of Mathematics and Statistics, McGill University, Montreal QC,
Canada
Correspondence Address
B. Nedelec, McGill University, Faculty of Medicine, 3654 Promenade Sir William Osler,
Montreal, QC H3G 1Y5, Canada
Country of Publication
United Kingdom
Publisher
Elsevier Ltd
Journal Translated Name
Burns
Keyword
Burns, Cutometer, High-frequency ultrasound, Hypertrophic scar, Mexameter,
Scanning, Skin injuries
URL
http://www.elsevier.com/locate/burns
Emtree Heading
adult; article; body surface; burn/su [Surgery]; *burn scar/su [Surgery]; Caucasian;
clinical article; clinical feature; controlled study; donor site; erythema; female;
human; hypertrophic scar/su [Surgery]; longitudinal study; male; pliability;
prospective study; skin analysis device; skin blood flow; skin elasticity meter; skin
pigmentation; skin transplantation; skinfold thickness; survivor; melanin/ec
[Endogenous Compound].
Drug Index Terms
melanin / endogenous compound.
Other Index Terms
adult; Article; body surface; burn / surgery; *burn scar / *surgery; Caucasian; clinical
article; clinical feature; controlled study; donor site; erythema; female; human;
hypertrophic scar / surgery; longitudinal study; male; pliability; prospective study;
skin analysis device; skin blood flow; skin elasticity meter; skin pigmentation; skin
transplantation; skinfold thickness; survivor.
Number of References
34
Embase Section Headings
Dermatology and Venereology [13], Biophysics, Bioengineering and Medical
Instrumentation [27], Clinical and Experimental Biochemistry [29]
Device Trade Names and Manufacturers
Cortex [Denmark], Courage Khazaka, Courage Khazaka [Germany], Cutometer:
Courage Khazaka [Germany], DermaScan C: Cortex [Denmark], Mexameter: Courage
Khazaka
CAS Registry Numbers
8049-97-6 (melanin)
ISSN
0305-4179
Electronic ISSN
1879-1409
DOI
http://dx.doi.org/10.1016/j.burns.2014.03.002
CODEN
BURND
Language

Page 24
English
Summary Language
English
Source Type
Journal
Entry Week
201500
Revised Date
20150807
Date Created
20150211
Year of Publication
2014
Copyright
Copyright 2015 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

11.

A validation study to find highly correlated parameters with visual assessment for
clinical evaluation of cosmetic anti-cellulite products.
Yoo M.A., Seo Y.K., Ryu J.H., Back J.H., Koh J.S.
Skin Research and Technology. 20 (2) (pp 200-207), 2014. Date of Publication: May
2014.
[Article]
AN: 52770845
Background/purpose: There has been growing interest in cellulite on parts of the
body; however, no objective assessment has been specifically established. This study
aims to demonstrate an optimized method by comparing the existing assessments of
cellulite. Methods: In Test 1, for subjects of 20 healthy females who have cellulite, we
measured volume and roughness of cellulite using fringe projection method,
roughness using replica method, dermo-subcutaneous interface length and
subcutaneous thickness using ultrasonography and skin temperature using infrared
ray, elasticity and blood flow. In Test 2, we applied an anti-cellulite cosmetic to 28
subjects for 6 weeks and observed if they have any changes. Results: In Test 1, the
effective parameter that is the most correlated with visual assessment was volume of
skin measured using fringe projection method (r = 0.780). Dermo-subcutaneous
interface length (r = 0.355) and subcutaneous thickness (r = 0.502) measured using
ultrasonography followed in order. In Test 2, after applying a tested product, the
correlation coefficient of volume of skin, of dermo-subcutaneous interface length and
of subcutaneous thickness are 0.409 (P = 0.000), 0.275 (P = 0.016) and 0.311 (P =
0.012) respectively. Conclusion: We conclude that visual assessment, volume of skin
(cavities), dermo-subcutaneous interface length and subcutaneous thickness are
optimized methods for assessing an effect of cosmetics on cellulite. © 2013 John
Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Embase Accession Number

Page 25
2014266803
PMID
24010809 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24010809]
Status
Embase
Author Email
Koh J.S.; dermapro@dermapro.co.kr
Institution
(Yoo, Seo, Ryu, Back, Koh) Dermapro/Skin Research Center, Jiho B/D, 919-1 Bangbae
Dong, Seocho Gu 137-843, Seoul, South Korea
Correspondence Address
J.S. Koh, Dermapro/Skin Research Center, Jiho B/D, 919-1 Bangbae Dong, Seocho Gu
137-843, Seoul, South Korea. E-mail: dermapro@dermapro.co.kr
Country of Publication
United Kingdom
Publisher
Blackwell Publishing Ltd (E-mail: customerservices@oxonblackwellpublishing.com)
Journal Translated Name
Skin Research and Technology
Keyword
3D image analysis, Anti-cellulite, Cellulite, Ultrasonography
URL
http://www3.interscience.wiley.com/journal/118541474/home
Emtree Heading
article; cellulite/dt [Drug Therapy]; *clinical assessment; clinical evaluation;
controlled study; echography; elasticity; evening dosage; female; human; human
experiment; infrared radiation; morning dosage; normal human; randomized
controlled trial; single blind procedure; skin blood flow; *skin disease/dt [Drug
Therapy]; skin disease/dt [Drug Therapy]; skin elasticity meter; *skin examination;
skin temperature; skinfold thickness; thermometer; ultrasound transducer; validation
study; *cosmetic/ct [Clinical Trial]; *cosmetic/dt [Drug Therapy]; placebo; skin cream;
unclassified drug; *cellulite/dt [Drug Therapy]; *visual assessment; *anti cellulite
cosmetic/ct [Clinical Trial]; *anti cellulite cosmetic/dt [Drug Therapy].
Candidate Terms
*cellulite / *drug therapy [other term]; *visual assessment [other term]; *anti cellulite
cosmetic / *clinical trial / *drug therapy [drug term].
Drug Index Terms
*cosmetic / *clinical trial / *drug therapy; placebo; skin cream; unclassified drug.
Other Index Terms
article; cellulite / drug therapy; *clinical assessment; clinical evaluation; controlled
study; echography; elasticity; evening dosage; female; human; human experiment;
infrared radiation; morning dosage; normal human; randomized controlled trial;
single blind procedure; skin blood flow; *skin disease / *drug therapy; skin disease /
drug therapy; skin elasticity meter; *skin examination; skin temperature; skinfold
thickness; thermometer; ultrasound transducer; validation study.
Triple Subheading
cellulite / drug therapy / anti cellulite cosmetic; cellulite / drug therapy / cosmetic;
skin disease / drug therapy / anti cellulite cosmetic; skin disease / drug therapy /
cosmetic; anti cellulite cosmetic / drug therapy / cellulite; anti cellulite cosmetic /
drug therapy / skin disease; cosmetic / drug therapy / cellulite; cosmetic / drug
therapy / skin disease.
Number of References
16
Embase Section Headings

Page 26
Dermatology and Venereology [13], Radiology [14], Biophysics, Bioengineering and
Medical Instrumentation [27], Drug Literature Index [37]
Device Trade Names and Manufacturers
Courage Khazaka [Germany], Cortex [Denmark], FLIR [Sweden], Dermascan C: Cortex
[Denmark], MPA580: Courage Khazaka [Germany], ThermaCAM: FLIR [Sweden]
ISSN
0909-752X
Electronic ISSN
1600-0846
DOI
http://dx.doi.org/10.1111/srt.12106
CODEN
SRTEF
Language
English
Summary Language
English
Source Type
Journal
Entry Week
201500
Revised Date
20150126
Date Created
20140501
Year of Publication
2014
Copyright
Copyright 2015 Elsevier B.V., All rights reserved.

Link to the Ovid Full Text or citation:


Click here for full text options

Link to the External Link Resolver:


Article Linker

Page 27