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5/6/2019 Definition of Anergy

Medical De nition of Anergy  Privacy


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Medical Author: William C. Shiel Jr., MD, FACP, FACR

Anergy: A state of immune unresponsiveness. Induced when the T cell's antigen receptor is stimulated, effectively
freezing T cell responses pending a "second signal" from the antigen-presenting cell. The delivery of the second
signal by the antigen-presenting cell rescues the activated T cell from anergy, allowing it to produce the
lymphokines necessary for the growth of additional T cells.

T cells are small white blood cells that orchestrate and directly participate in the immune defenses. Also known as
T lymphocytes, they are processed in the thymus (which is why they are called T cells).

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Reviewed on 12/27/2018

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