U.S. ARMY EDGEWOOD RESEARCH, DEVELOPMENT / \ AND ENGINEERING CENTER REVISED: 30 June 95 DATE: 18 June 1982 Emergency Telephone #s: ERDEC Safety Office 410-671-4411 0800-1630 EST After normal duty ) hours: 410-278-5201 \ / Ask for ERDEC Staff Duty Officer MATERIAL SAFETY DATA SHEET SECTION I - GENERAL INFORMATION CAS REGISTRY NUMBE! 6581-06-2 MANUFACTURER'S ADDRESS: U.S. ARMY CHEMICAL AND BIOLOGICAL DEFENSE COMMAND EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ATTN: _SCBRD-ODR-S ABERDEEN PROVING GROUND, MD 21010-5423 CHEMICAL NAME AND SYNONYMS: Benzilic Acid, 3-Quinuclidinyl ester 3-Hydroxyquinuclidine benzilate 3-Oxyquinuclidine benzilate 3-Quinuclidinylbenzilate beta-Quinuclidinyl benzilate RADE NAME AND SYNONYMS: BZ, EA2277 CHEMICAL FAMILY: Glycolate FORMULA/CHEMICAL STRUCTURE: leer oH OO f\ 1 tl \ / |---c-C-0 2 NEPA 704 SIGNAL: Health - 3 N Flammability- 1 /u\ Reactivity- ° AW i \ \3/\o / VV \ of VV SECTION TI - HAZARDOUS INGREDIENTSFORMULA PERCENTAGE, PEL BY WEIGHT Ba 21H23NO3 100% PEL: .004mg/m3 (proposed) SECTION IIT - PHYSICAL DATA BOILING POINT DEG F (DEG C): 774 (412) VAPOR PRESSURE: Negligible, about 3 X 10-5 mm Hg @ 70 Deg C VOLATILITY: .47 mg/m3 @ 70 Deg C VAPOR DENSITY (AIR=1): 11.6 SOLID DENSITY: Bulk Density - .51 g/cm3 crystal Density - 1.33 g/cm3 SOLUBILITY: | Negligible in water. Complete in halogenated hydrocarbon compounds. Moderate in methanol and ethanol solutions (50 to 70%). MOLECULAR WEIGHT: 337.4 STABILITY: Resistant to atmospheric degradation. Stable in storage. ‘Thermally stable above its melting point. MELTING POINT: 167.50 Deg C APPEARANCE AND ODOR: Beige to white crystalline solid. Odorless. SECTION IV - FIRE AND EXPLOSION DATA FLASHPOINT (METHOD USED): 246 Deg C - Sublimated sample (McCutchen - Young) 220 Deg C - Process lab sample (McCutchen - Young) EXPLOSVIE LIMITS: 0.88 to 2.5 grams/ft3 EXTINGUISHING MEDIA: Water, Dry Chemical, C02, Halon SPECIAL FIRE FIGHTING PROCEDURES: Use NIOSH approved pressure-demand SCBA for fire-fighting UNUSUAL FIRE AND EXPLOSION HAZARD: BZ is a combustible solid and can form explosive mixtures in air SECTION V - HEALTH HAZARD DATA MISSIBLE EXPOSURE LIMIT: The suggested permissible airborne exposure concentration for BZ for an_ 8- hour workday or a 40-hour work week is an 8-hour time weighted average (TWA) cf 0.004 mg/m3, with a Short Term Exposure Limit (STEL) that should not exceed 0.006 mg/m3 during any 15 minute exposure period, provided that nomore than four excursions per day are permitted, with at least 60 rinutes between exposure periods. It is further suggested that for the general population, a ceiling airborne exposure concentration of 0.0001 ng/m2 or BZ must not be exceeded at any time. These values are based on the “Interim Design Exposure Acceptable Limits (IDEALS)" for workers at, and general population in the vicinity of BA demil. site, as proposed to Office of the Surgeon General (OTSG) by the USA Environmental Hygiene Agency (USAEHA). To date, however, the Occupational Safety and Health Administration (OSHA) has not promulgated permissible exposure concentration for BZ. BZ is not listed by the International Agency for Re- search on Cancer (IARC), American Conference of Governmental Industrial Hy- gienists (ACGIH), Occupational Safety and Health Administration (OSHA), or National Toxicology Program (NTP) as a carcinogen. FSFRCTS OF OVEREXPOSURE: BZ a very potent psychoactive chemical affecting the central nervous system as well as the organs of circulation, digestion, salivation, sweating and vision. Its pharmacological action is similar to that of other anti- cholinergic drugs (e.g., atropine, scopolamine, etc.), but longer lasting. Routes of entry into the body include inhalation, oral, skin (with proper solvent) and eye (local). For man, the inhalation incapacitating dose ICtSO = 101 mg-min/m3 (at 15 l/min breathing rate) and the IV or IM ID50 equal to approximately 5.5 micro grams per kilogram. For animals, the inhalation LCt50 (mouse) 12,00 mg/m3 (t = 5-10 min); for rat_ 64,000 mg-min/m3 (t = 5-30 min); and for monkey, 37,000 mg/min/m3 (t = 6-25 min). By IV route, LD 50 for mouse, rat, and monkey are 14.1, 14.1 and 10.4 mg/kg respectively. Oral LD 50 (cat) = 50 mg/kg. Minimum effective dose in man by IV or IM routes = 2.5 - 2.7 ug/kg, produc- ing increased heart rate as well as mild but behaviorally significant reduction of performance capability. Route exposure to > 6-8 ug/kg BZ produces both anticholinergic like symptoms (increased heart and respiratory rates; mydriasis; mouth; skin and lip cycloplegia; high temperature; ataxia; and flushing of face and ), as well as psychotropic symptoms (hallucination; stupor; forgetful- ass; and confusion) Initial symptoms, after 1/2 to 4 hours of exposure, include dizziness, mouth dryness and increased heart rate. Secondary symptoms, after 3-5 hours of exposure, include restlessness, involuntary muscular movements, rear vision impairment and total incapacitation. Final symptoms, after 6-10 hours of exposure are psychotropic in nature. After 3-4 days, full recovery from BZ intoxication is expected. *See Addendum A for more detailed information on onset times and symptoms. N» data from chronic exposure of animals or man are available. EMERGENCY AND FIRST AID PROCEDURES: Escause of possible severe heat stroke by any of the following exposure routes, remove excessive clothing, if environmental temperature is above 79 DEG (21 DEG C). Give fluids’ only if patient is able to drink un- assisted. INHALATION: Immediately remove from exposure. Seek medical attention immediately. If breathing is irregular or has stopped, start resuscitation