You are on page 1of 7


International Journal of Mental Health Nursing (2016) , – doi: 10.1111/inm.12260

Factors associated with psychotic relapse in
patients with schizophrenia in a Pakistani cohort
Irshad Ahmad,1 Muhammad Tahir Khalily,1 Brian Hallahan2 and Inayat Shah3
Department of Psychology, International Islamic University Islamabad, Islamabad,Pakistan, 2Department of
Psychiatry, National University of Ireland, Galway, Ireland, and 3Department of Psychology,University of
Malakand, Khyber Pakhtunkhwa, Pakistan

ABSTRACT: Despite a large body of research evaluating factors associated with the relapse of
psychosis in schizophrenia, no studies in Pakistan have been undertaken to date to identify any
such factors, including specific cultural factors pertinent to Pakistan. Semistructured interviews
and psychometric measures were undertaken with 60 patients diagnosed with schizophrenia (49
male and 11 female) and their caregivers at four psychiatric hospitals in the Peshawar region in
Pakistan. Factors significantly associated with psychotic relapse included treatment non-
adherence, comorbid active psychiatric illnesses, poor social support, and high expressed emotion
in living environments (P < 0.05). The attribution of symptoms to social and cultural values
(97%) and a poor knowledge of psychosis by family members (88%) was also prevalent. In
addition to many well-documented factors associated with psychotic relapse, beliefs in social and
cultural myths and values were found to be an important, and perhaps treatable, factor associated
with relapse of psychosis in Pakistan. The provision of evidence-based psychotherapeutic
interventions, such as behaviour and family therapy and cognitive behaviour therapy for
psychosis, could potentially ameliorate the relapse rate of psychosis in Pakistan.
KEY WORDS: culture, relapse of psychosis, schizophrenia.

achieve symptomatic remission (Falkai et al. 2005).

Unfortunately, psychotic relapse is common and is
Schizophrenia is a long-term and often disabling men- associated with significant deleterious effects for the
tal illness affecting approximately 1% of the world’s individual and their family, including a worsening of
population, with no significant difference in prevalence clinical symptoms, impaired functionality, a reduced
between countries or cultures (Insel 2010; Mueser & quality of life, and an increased financial burden for
McGurk 2004). In a majority of people, schizophrenia the patient and potentially their family members or
is associated with functional impairment, including carer (Awad & Voruganti 2008; Falkai et al. 2005; Kane
poor occupational attainment (Marwaha et al. 2007). et al. 2007; Robinson et al. 2005)). Consequently,
However, with active intervention, most patients can understanding the factors associated with psychotic
relapse in schizophrenia and engaging in management
Correspondence: Irshad Ahmad, Department of Psychology, Fac- strategies to reduce the risk of such a relapse can be
ulty of Social Sciences, Room no. 207 A, Block-II, Sector H-10, beneficial.
International Islamic University, Islamabad 44000, Pakistan. Email: Several factors have previously been associated with
Irshad Ahmad, MSc, MS. psychotic relapse. The factors most commonly cited
Muhammad Tahir Khalily, MSc, PMDCP, MPhil, PhD. include treatment non-adherence, comorbid depression
Brian Hallahan, MRC Psych, MS.
Inayat Shah, MSc, MS.
or psychoactive substance misuse, and stressful life
Accepted July 26 2016. events (Kazadi et al. 2008; Moeller et al. 2006; Uc€ ßok

© 2016 Australian College of Mental Health Nurses Inc.


et al. 2006). Additional factors associated with relapse symptomatology by the first author (Kay et al. 1987).
include limited insight into one’s illness, high expressed The presence of symptoms on this 30-item scale was
emotion (EE) (high levels of criticism and emotional rated from one (absent) to seven (extreme). The
over-involvement) and the attribution of mental illness PANSS and has well-documented good reliability
to social and cultural myths and values or religious indices (a = 0.73–0.79) (Kay et al. 1987). A specifically-
attributions (Butzlaff & Hooley 1998; Lauber & R€ossler designed clinical profile sheet was used for assessing
2007; Reddy et al. 2014; Sultan 2006; Zafar et al. clinical and biopsychosocial factors. The responses
2008). obtained were subsequently validated by examining
To date, in Pakistan, no study has examined factors clinical records of the patient and from the collateral
associated with psychotic relapse in individuals with history provided by their caregivers. These data,
schizophrenia. Consequently, in the present study, we including EE, understanding of one’s illness, medica-
wanted to ascertain factors associated with relapse in a tion non-adherence, psychosocial stressors, and family
cohort of individuals with schizophrenia in Pakistan, knowledge and beliefs about illness and attribution,
examine if these factors are similar to those noted in were attained from these interviews. Interviews with
other countries, and explore whether any specific fac- patients required 1–2 hours over one-to-two sessions.
tors pertaining to relapse of psychosis are present in Interviews with caregivers lasted approximately 90 min.
Pakistan that are not as prevalent in other countries or Additional information relating to these factors was
regions. attained from clinical note reviews and discussions with
the treating clinical team.
Ethical approval was attained prior to the com-
mencement of this study from the Clinical Research
Ethics Committee, Department of Psychology, Interna-
tional Islamic University, Islamabad, Pakistan, with
The sample consisted of 60 individuals with individual approval obtained from the head of each of
schizophrenia, diagnosed by an experienced consultant the four tertiary care centres included in the study.
psychiatrist utilizing International Classification of Dis- Individuals were identified by their treating team that
eases-10 operational criteria. All patients had previously initially approached them in relation to study participa-
suffered at least one psychotic relapse. All participants tion. After sufficient time was given for study consider-
were actively engaged (inpatients) with the adult men- ation (at least 1 week), patients were then approached
tal health services (at the time of the study), and by the first author (IA), the study was explained to
attended one of four tertiary care mental health ser- them in more detail, and informed consent to partici-
vices in the Peshawar region of Pakistan (Departments pate was obtained by those who agreed to participate.
of Psychiatry, Khyber Teaching Hospital, Hayatabad Six individuals declined to participate. All data were
Medical Complex, Lady Reading Hospital, and the Sar- anonymized and coded.
had Hospital for Psychiatric Diseases). All participants
had undergone recent review (at study entry) by their
Data analysis
consultant psychiatrist to confirm diagnosis and rule
out other potential diagnoses or factors that could Statistical analysis was performed using the Statistical
account for a psychotic relapse. Exclusion factors Package for Social Sciences 22.0 for Windows (SPSS,
included individuals <18 years or >65 years of age, the IBM, Armonk, NY, USA). For parametric data, the
presence of a psychotic illness other than schizophrenia independent sample t-test was utilized to compare
(i.e. schizoaffective disorder, bipolar disorder, or drug- means between groups. Pearson correlation coefficient
induced psychosis), or the presence of an intellectual was utilized to undertake correlational analysis between
disability or dementia. scores on the PANSS and various clinical and social
Basic clinical and demographic data were attained factors associated with relapse.
for each study participant, including age, sex, socioeco-
nomic status, occupational status, and relationship sta-
tus, via clinical note reviews, patient interviews, and
discussions (where necessary) with the treating clinical The demographic characteristics of the 60 included
team. The Positive and Negative Syndrome Scale individuals who participated in the present study are
(PANSS) was administered to all patients to assess presented in Table 1. Eighty-two percent of the sample

© 2016 Australian College of Mental Health Nurses Inc.


TABLE 1: Socio-demographic characteristics of patients (n = 60) TABLE 2: Clinical factors potentially associated with psychotic
Variables n (%) Mean (SD) Range
Variables n (%) Mean (SD) Range
Age 32.70 (8.34) 19–59
19–30 30 (50) PANSS score – 98.77 (12.12) 74–117
31–40 17 (28.3) Positive syndrome – 25.02 (5.08) 12–35
40+ 13 (21.7) Negative syndrome – 25.20 (4.25) 14–33
Gender General – 48.97 (7.63) 25–60
Male 49 (81.7) psychopathology
Female 11 (18.3) Age of onset (years)
Relationship status 19–25 44 (73.3) 23.42 (4.35) 19–33
Single 22 (36.7) 26–30 16 (26.7)
Married 38 (63.3) Duration of illness (years)
Socioeconomic status 1–5 14 (23.3) 8.83 (5.39) 1–23
$A<149.28 (<12 000 PKR Rs) 37 (61.7) 6–10 25 (41.7)
$A<248.81 (<20 000 PKR Rs) 23 (38.3) 11–15 15 (25)
Vocational status 15+ 6 (10)
Employed* 20 (33.3) Hospitalization history
Unemployed 40 (66.6) 2nd time 16 (26.7)
Education 3rd time 11(18.3)
None 14 (23.3) >3 times 33 (55)
Primary 19 (31.7) Comorbid psychiatric illnesses
Post-primary 16 (26.7) Major depressive 30 (41.1)
Secondary level 4 (6.7) episode
Third level 5 (8.3) Substance use 23 (33.8)
High level 2 (3.3) disorder
Generalized anxiety 13 (17.6)
The monthly minimum wage in Khyber Pakhtunkhwa Pakistan is disorder
$A<149.28 (<12 000 PKR Rs) (Paycheckpk, 2015). The literacy rate Obsessive compulsive 3 (4.4)
in Pakistan is 55% (Literacy Rate of Education in Pakistan, 2015). disorder
*Employment nature consisted of permanent, temporary and contract Comorbid medical conditions
workers. Metabolic disorders, including 6 (22.2)
Liver disease, including 1 (3.7)
were male, and the mean age of the cohort was 32.7 hepatitis
Long-term pain, including 9 (33.3)
(standard deviation (SD): 8.3) years. Sixty-seven per-
cent of the sample was not engaged in active employ- Neurological conditions, 6 (22.2)
ment, 81% had not completed secondary school including migraine
education, and 62% had a monthly income below Epilepsy 5 (18.5)
$A150.45 (12 000 Pakistani rupees). Nobody from the
PANSS, Positive and Negative Syndrome Scale; SD, standard
cohort had been internally displaced from other deviation.
jurisdictions, such as Afghanistan.
Data pertaining to clinical factors are presented in
Table 2. The mean age of onset was 23.4 (SD: 4.4) psychiatric illnesses (95%), including depression
years, and the median of age of onset was 21 (range: (40%), substance abuse disorders (31%), and anxiety
19–41) years. Comorbid mental health (particularly disorders (18%) that were significantly associated with
depression (40.5%)), physical health (particularly pain psychotic relapse. Other non-pharmacological factors
conditions (20.3%)), and psychoactive substance misuse associated with not engaging with psychiatry when
(particularly cannabis (37.1%)) were common. PANSS symptoms emerged prior to psychotic relapse included
scores at study entry demonstrated significant the attribution of symptoms based on social and cul-
pathology. tural myths and values (97%) and a poor knowledge
Based on the responses obtained from patients on of the symptoms of psychosis from family members
the PANSS and semistructured interviews, we subse- (88%). In addition, high EE at home prepsychotic
quently examined patients’ clinical records and the relapse (based on interviews with both patients and
collateral history given by their caregivers to deter- family members) was evident in relation to 63% of
mine treatment non-adherence (95%) and comorbid patients (Table 3).

© 2016 Australian College of Mental Health Nurses Inc.


TABLE 3: Psychosocial factors potentially associated with psychotic comorbid mental and physical illnesses, psychoactive
relapse substance misuse, high EE, and a poor understanding
Psychosocial factors n (%) of mental illnesses at home and the attribution of
symptoms based on social and cultural myths and
Treatment non-adherence
Yes 57 (95)
No 3 (5) The most notable finding in the present study
Poor social support related to the practice of misattributing symptoms
Yes 23 (38.3) based on social and cultural myths and values. In Pak-
No 37 (61.7) istan (as in many other countries), the attribution of
High EE in home setting
psychiatric illness to magical influences, the presence
Yes 38 (61.3)
No 22 (36.7) of evil spirits, neglect of ritual obligations, or violations
Significant psychosocial stressor prerelapse of taboos is common (Ahmad & Rashid 2006). The
Yes 25 (41.7) attribution of psychotic symptoms to social and cultural
No 35 (58.3) myths and values were noted to reflect both patients
Poor family knowledge about illness
and family members’/carers’ views of symptoms.
Yes 7 (11.7)
No 53 (88.3) Indeed, there is a well-documented practice of ‘Taa-
Attribution of illness to social and cultural myths and values weez’ or ‘jinn’, which involves taking a patient with a
Yes 58 (96.7) mental illness to a local religious healer for treatment
No 2 (3.3) (Ahmad & Rashid 2006). The present study demon-
EE, expressed emotion. strated that a significant percentage of patients and
family relatives or carers attributed symptoms to social
and cultural myths and values rather than mental ill-
Higher PANSS scores were demonstrated in individ- ness, resulting in individuals having longer periods of
uals with high EE at home, attribution of symptoms untreated psychoses and consequent admissions to psy-
based on social and cultural myths and values, poor chiatric inpatient units. This finding replicates those
family knowledge of illness, lack of motivation, and lack from a number of studies in other jurisdictions, which
of insight (Table 4), with these factors also positively also demonstrated a significant association between
correlated with PANSS scores (Table 5). beliefs in social and cultural myths and values and psy-
chotic relapse (Zafar et al. 2008). Not surprisingly, and
DISCUSSION in keeping with the findings in the literature, poor
insight was present in most individuals who developed
To the best of our knowledge, the present study was a psychotic relapse (Amador et al. 1994; Reddy et al.
the first to examine clinical and social factors associated 2014)
with psychotic relapse in a cohort of patients with Treatment non-adherence prepsychotic relapse was
schizophrenia in Pakistan. Factors associated with psy- common in the present study (95%). While this finding
chotic relapse included treatment non-adherence, is consistent with international literature, treatment

TABLE 4: PANSS scores and variables associated with psychosocial stressors

Psychosocial stress No psychosocial stress
Variables Mean (SD) Mean (SD) t (95% CI) P-value Cohen’s d

Family history of schizophrenia 100.00 (12.40) 93.70 (10.60) 1.97 ( 12.55, 0.09) 0.04 0.55
Poor social support 102.43 (11.28) 96.92 (13.84) 1.61 ( 12.38, 1.35) 0.11 0.44
High EE in home environment 101.74 (11.68) 94.36 (14.34) 2.17 ( 14.19, 0.55) 0.03 0.56
Attribution of illness to social and 99.64 (13.09) 85.50 (3.53) 1.51 ( 32.84, 4.56) 0.03 1.47
cultural myths and values
Stressful life events 97.04 (12.89) 99.51 (12.27) 0.75 ( 4.09, 9.05) 0.45 0.19
Poor family knowledge of illness 100.40 (11.44) 84.00 (11.06) 3.57 ( 25.57, 7.22) 0.001 1.46
Lack of motivation 104.55 (12.47) 95.45 (11.48) 2.81 ( 15.58, 2.62) 0.007 0.76
Lack of insight 100.69 (11.10) 91.87 (14.40) 2.47 ( 15.97, 1.67) 0.01 0.69

CI, confidence interval; EE, expressed emotion; PANSS, Positive and Negative Syndrome Scale; SD, standard deviation.

© 2016 Australian College of Mental Health Nurses Inc.


TABLE 5: Correlations between PANSS and clinical or psychosocial factors

Clinical or psychosocial factors 1 2 3 4 5 6 7 8 9

1. PANSS 1
2. High EE in home settings 0.281* 1
3. Attribution of illness to social and 0.236* 0.051 1
cultural myths and values
4. Stressful life events 0.157 0.012 0.157 1
5. Poor social support 0.226* 0.458** 0.146 0.041 1
6. Poor family knowledge of illness 0.429** 0.154 0.222* 0.325** 0.180 1
7. Treatment non-adherence 0.232* 0.224* 0.278* 0.123 0.292* 0.054 1
8. Comorbid medical diseases 0.154 0.234* 0.246* 0.179 0.125 0.326** 0.086 1
9. Comorbid psychiatric illnesses 0.278* 0.026 0.057 0.311** 0.091 0.180 0.371** 0.254* 1
P < 0.05, P < 0.01. EE, expressed emotion; PANSS, Positive and Negative Syndrome Scale.

modalities to increase adherence rates are not currently psychologists employed, the provision of such interven-
available in Pakistan, and thus it is likely in the short- tions will continue to be largely unavailable. For exam-
to-medium term that high rates of psychotic relapse ple, for every 100 000 people, only 8.13 mental health
will continue (Morken et al. 2008). No patients in the nurses (n = 13 643) are employed (predominantly in
present study had access to any type of psychothera- inpatient mental health units), which is less than 40%
peutic interventions other than supportive psychother- of the median rate of mental health nurses employed
apy from staff members when admitted to psychiatric in the European Union (WHO, Europe. 2014).
inpatient units. An increasing evidence base demon- In addition, increased resources to manage comor-
strates lower relapse rates secondary to the provision of bidities, including depression and psychoactive sub-
various psychotherapeutic interventions, including cog- stance ingestion, might also be beneficial in reducing
nitive behaviour therapy for psychosis, family therapy, relapse rates, given the high prevalence of these
or a combination of both (Aderhold & Gottwalz 2004; comorbidities noted, a finding consistent with several
Kuipers & Bebbington 2006; Pilling et al. 2002; Tarrier other studies (Buckley et al. 2009).
et al. 1999). It is plausible that the introduction of such There are a number of limitations with the present
psychotherapeutic interventions could lessen the need study. These include the fact that the results might not
for psychotropic medication, given concerns regarding be generalizable to the total population of Pakistan,
the significant adverse sequelae that psychotropic med- particularly as no private hospitals were included,
ication have and that the risks of being on medication where resource provision is potentially greater. The
can outweigh the benefits over time (Moncrieff 2006). sample size is relatively small; however, this is the first
It is probable that an increase in the provision of such study to be conducted in Pakistan and will serves
psychotherapeutic interventions could have a positive as a basis for larger studies to be conducted in multiple
effect on readmission and relapse rates long-term ill- centres. While family members and relatives were
ness, particularly if such interventions could also interviewed in depth, further qualitative techniques,
address patients and relatives’/carers’ views that symp- including focus groups and qualitative analyses, were
toms are related to social and cultural myths and val- not conducted, which should be the focus of future
ues. It has been shown that mental health nurses and studies. In addition, psychometric instruments for the
psychologists play a signficant role in the provision of measurement of patients’ and families’ understanding
physical health care and in the delivery of appropriate of patients’ illnesses, and for levels of EE, were not
psychosocial and psychotheapuetic interventions to undertaken, which would have been optimal.
patients and their relatives and carers (Bradshaw &
Pedley 2012; Gamble 1995). Such interventions include
psychoeducation and behaviour and family therapy to
patients with psychosis and their carer(s) and cognitive While the present study replicated several known risk
behaviour therapy (Turkington et al. 2002, 2006). In factors for psychotic relapse in schizophrenia, such as
Pakistan, at present, there is a dearth of such resources treatment non-adherence and psychoactive substance
available in mental health services, and consequently misuse, one significant factor related to the attribution
without greater numbers of mental health nurses and of psychotic symptoms to social and cultural values,

© 2016 Australian College of Mental Health Nurses Inc.


which resulted in a lack of treatment of psychotic Kuipers, E. & Bebbington, P. (2006). Cognitive behaviour
symptoms. Given the dearth of psychotherapeutic therapy for psychosis. Epidemiologiae psichiatria sociale,
interventions currently available in Pakistan for the 15, 267–275.
Lauber, C. & R€ ossler, W. (2007). Stigma towards people with
treatment of psychosis, the present study highlights the
mental illness in developing countries in Asia.
urgent need for appropriate evidence-based psy- International Reviews of Psychiatry, 19, 157–178.
chotherapeutic interventions, including cognitive beha- Literacy Rate of Education in Pakistan (2015). [Cited 06 May
viour therapy for psychosis and behaviour and family 2015]. Available from Archivist online, website, http://
therapy for patients (and their relatives and carers).
Marwaha, S., Johnson, S., Bebbington, P. et al. (2007). Rates
and correlates of employment in people with
REFERENCES schizophrenia in the UK, France and Germany. British
Journal of Psychiatry, 191, 30–37.
Aderhold, V. & Gottwalz, E. (2004). Family therapy and Moeller, K. E., Shireman, T. I. & Liskow, B. I. (2006). Relapse
schizophrenia. Replacing ideology with openness. In: W. J. rates in patients with schizophrenia receiving aripiprazole in
Read, L. R. Mosher & R. P. Bental (Eds). Models of comparison with other atypical antipsychotics. Journal of
Madness. (pp. 335–347). Hove: Brunner-Routledge. Clinical Psychiatry, 67, 1942–1947.
Ahmad, R. & Rashid, A. (2006). Perceived emotional Moncrieff, J. (2006). Why is it so difficult to stop psychiatric
expression in the family and psychopathology. Pakistan drug treatment? It may be nothing to do with the original
Journal of Psychology, 37, 13–20. problem. Medical Hypotheses, 67, 517–523.
Amador, X. F., Flaum, M., Andreasen, N. C. et al. (1994). Morken, G., Widen, J. H. & Grawe, R. W. (2008). Non-
Awareness of illness in schizophrenia and schizoaffective adherence to antipsychotic medication, relapse and
and mood disorders. Archives of General Psychiatry, 51, rehospitalisation in recent-onset schizophrenia. BMC
826–836. Psychiatry, 8, 32.
Awad, A. G. & Voruganti, L. N. (2008). The burden of Mueser, K. T. & McGurk, S. R. (2004). Schizophrenia. The
schizophrenia on caregivers. Pharmacoeconomics, 26, 149– Lancet, 363, 2063–2072.
162. Paycheckpk. (2015). Minimum Wage in Khyber
Bradshaw, T. & Pedley, R. (2012). Evolving role of mental Pakhtunkhwa, Pakistan 2014-2015. Paycheckpk. [Cited 21
health nurses in the physical health care of people with April 2015]. Available from:
serious mental health illness. International Journal of salary/minimum-wages/minimum-wage-2014-2015
Mental Health Nursing, 21, 266–273. Pilling, S., Bebbington, P., Kuipers, E. et al. (2002).
Buckley, P. F., Miller, B. J., Lehrer, D. S. & Castle, D. J. Psychological treatments in schizophrenia: I. Meta-analysis
(2009). Psychiatric comorbidities and schizophrenia. of family intervention and cognitive behaviour therapy.
Schizophrenia Bulletin, 35, 383–402. Psychological Medicine, 32, 763–782.
Butzlaff, R. L. & Hooley, J. M. (1998). Expressed emotion Reddy, S., Thirthalli, J., Channaveerachari, N. et al. (2014)
and psychiatric relapse: A meta-analysis. Archives of Factors influencing access to psychiatric treatment in
General Psychiatry, 55, 547–552. persons with schizophrenia: A qualitative study in a rural
Falkai, P., Wobrock, T., Lieberman, J. et al. (2005). World community. Indian Journal of Psychiatry, 56, 54–60.
Federation of Societies of Biological Psychiatry (WFSBP) Robinson, D. G., Woerner, M. G., Delman, H. M. & Kane,
guidelines for biological treatment of schizophrenia, Part J. M. (2005). Pharmacological treatments for first-episode
1: Acute treatment of schizophrenia. The World Journal of schizophrenia. Schizophrenia Bulletin, 31, 705–722.
Biological Psychiatry, 6, 132–191. Sultan, F. M. (2006). Factors delaying psychiatric consultation
Gamble, C. (1995). The Thorn nurse training initiative. in first episode psychosis - A retrospective cross-sectional
Nursing Standards, 9, 31–34. study. Journal of Medical Science, 14, 21–25.
Insel, T. R. (2010). Rethinking schizophrenia. Nature, 468, Tarrier, N., Wittkowski, A., Kinney, C., McCarthy, E.,
187–193. Morris, J. & Humphreys, L. (1999). Durability of the
Kane, J. M., Meltzer, H. Y., Carson, W. H. Jr, McQuade, R. D., effects of cognitive-behavioural therapy in the treatment
Marcus, R. N. & Sanchez, R. (2007). Aripiprazole for of chronic schizophrenia: 12-month follow-up. British
treatment-resistant schizophrenia: Results of a multicenter, Journal of Psychiatry, 174, 500–504.
randomized, double-blind, comparison study versus Turkington, D., Kingdon, D. & Turner, T. (2002).
perphenazine. Journal of Clinical Psychiatry, 68, 213–223. Effectiveness of a brief cognitive—behavioural therapy
Kay, S. R., Flszbein, A. & Opfer, L. A. (1987). The positive intervention in the treatment of schizophrenia. British
and negative syndrome scale (PANSS) for schizophrenia. Journal of Psychiatry, 180, 523–527.
Schizophrenia Bulletin, 13, 261. Turkington, D., Kingdon, D., Rathod, S., Hammond, K., Pelton,
Kazadi, N., Moosa, M. & Jeenah, F. (2008). Factors J. & Mehta, R. (2006). Outcomes of an effectiveness trial of
associated with relapse in schizophrenia. South African cognitive-behavioural intervention by mental health nurses in
Journal of Psychiatry, 14, 52–62. schizophrenia. British Journal of Psychiatry, 189, 36–40.

© 2016 Australian College of Mental Health Nurses Inc.


€ ßok, A., Polat, A., C

Uc ß akır, S. & Gencß, A. (2006). One year Zafar, S. N., Syed, R., Tehseen, S. et al. (2008). Perceptions
outcome in first episode schizophrenia. European Archives about the cause of schizophrenia and the subsequent help
of Psychiatry and Clinical Neuroscience, 256, 37–43. seeking behavior in a Pakistani population–results of a
World Health Organization, Europe. (2014). Mental Health cross-sectional survey. BMC Psychiatry, 8, 56.
Data and Statistics. [Cited 8 April 2015]. Available from:

© 2016 Australian College of Mental Health Nurses Inc.