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Meigs' syndrome

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Meigs' syndrome

Specialty Gynecologic oncology

Not to be confused with Meige syndrome or Meige disease

In medicine, Meigs' syndrome, also Meigs syndrome or Demons-Meigs syndrome, is the
triad of ascites, pleural effusion, and benign ovarian tumor (ovarian fibroma,
fibrothecoma, Brenner tumour, and occasionally granulosa cell tumour).[1][2][3] Meigs' syndrome
resolves after the resection of the tumor. Because the transdiaphragmatic lymphatic channels
are larger in diameter on the right, the pleural effusion is classically on the right side. The causes
of the ascites and pleural effusion are poorly understood. [1] Atypical Meigs' syndrome,
characterized by a benign pelvic mass with right-sided pleural effusion but without ascites, can
also occur. As in typical Meigs syndrome, pleural effusion resolves after removal of the pelvic


 1Diagnosis
o 1.1Differential diagnosis

 2Treatment

 3Eponym

 4References

 5External links

Differential diagnosis[edit]
Meigs syndrome may mimic other conditions, [4] since it is tumor arising from ovaries, pathology
of any organs present in the abdomen may show a similar set of symptoms. These include
various gynecological disorders of the uterus such as endometrial tumor, sarcoma, leiomyoma
(pseudo-Meigs syndrome); fallopian tube disorders such as hydrosalpinx, granulomatous
salpingitis, fallopian tube malignancy; ovarian disorders such as serous, mucinous,
endometrioid, or clear cell carcinoma, Brenner tumor, granulosa cell tumor, stromal tumor,
dysgerminoma, fibroma, or metastatic tumor to the ovary.
Meigs syndrome is characterized by the presence of a benign solid ovarian tumor associated
with ascites and right hydrothorax that disappear after tumor removal. Non-gynecological
manifestations include: ascites, portal vein obstruction, inferior vena cava obstruction,
hypoproteinaemia, thoracic duct obstruction, tuberculosis, amyloidosis, pancreatitis, ovarian
hyperstimulation, exudate[5] pleural effusion, congestive heart failure, metastatic tumors to the
peritoneal surfaces, collagen-vascular disease, and cirrhosis of the liver.
These entities must be clinically excluded. [citation needed] Clinical condition characterized by ovarian
mass, ascites, and right-sided pleural effusion.Ovarian malignancy and the other causes (see
“Differential Diagnosis”) of pelvic mass, ascites, and pleural effusion to be considered, History of
early satiety, weight loss with increased abdominal girth, bloating, intermittent abdominal pain,
dyspnea, nonproductive cough may help in differentiating potential local factor causing such

Treatment of Meigs' syndrome consists of thoracentesis and paracentesis to drain off the excess
fluid (exudate), and unilateral salpingo-oophorectomy or wedge resection to correct the
underlying cause.

Meigs' Syndrome is named for Joe Vincent Meigs.[6][7][8]

1. ^ Jump up to:a b c Meigs syndrome at eMedicine
2. ^ Morán-Mendoza A, Alvarado-Luna G, Calderillo-Ruiz G, Serrano-Olvera A, López-Graniel
CM, Gallardo-Rincón D (2006). "Elevated CA125 level associated with Meigs' syndrome: case
report and review of the literature". International Journal of Gynecological Cancer. 16 Suppl 1
(Suppl 1): 315–8. doi:10.1111/j.1525-1438.2006.00228.x. PMID 16515612.
3. ^ Padubidri D (2010). Shaw's Textbook Of Gynaecology, 15e. Elsevier India.
p. 385. ISBN 9788131225486.
4. ^ Lanitis S, Sivakumar S, Behranwala K, Zacharakis E, Al Mufti R, Hadjiminas DJ (January
2009). "A case of Meigs syndrome mimicking metastatic breast carcinoma". World Journal of
Surgical Oncology. 7: 10. doi:10.1186/1477-7819-7-10. PMC 2633000. PMID 19161612.
5. ^ Krenke R, Maskey-Warzechowska M, Korczynski P, Zielinska-Krawczyk M, Klimiuk J,
Chazan R, Light RW (December 2015). "Pleural Effusion in Meigs' Syndrome-Transudate or
Exudate?: Systematic Review of the Literature". Medicine. 94 (49):
e2114. doi:10.1097/MD.0000000000002114. PMC 5008483. PMID 26656338.
6. ^ Meigs' syndrome at Who Named It?
7. ^ Lurie S (October 2000). "Meigs' syndrome: the history of the eponym". European Journal of
Obstetrics, Gynecology, and Reproductive Biology. 92 (2): 199–204. doi:10.1016/S0301-
2115(99)00289-4. PMID 10996681.
8. ^ Meigs JV (May 1954). "Fibroma of the ovary with ascites and hydrothorax; Meigs'
syndrome". American Journal of Obstetrics and Gynecology. 67 (5): 962–85. doi:10.1016/0002-
9378(54)90258-6. PMID 13148256.