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Lovely Professional University,Punjab

Format For Instruction Plan [for Courses with Lectures and Labs ]

Course No. MLT536 Course Title: PHARMACEUTICAL MICROBIOLOGY L: 4 T: 0 P: 3 Cr: 6

Course Planner :- 11282 :: Naresh Kumar

TextBook

1. Pharmaceutical Microbiology Edt. by W.B.Hugo & A.D.Russell Sixth

Other Specific Books


2. Analytical Microbiology Edt by Frederick Kavanagh Volume I & II.
3. Quality control in the Pharmaceutical Industry - Edt. by Murray S.Cooper Vol.2.
4. The theory and practice of industrial pharmacy edt by Leon Lachman Herbert A. lieberman

Other Readings

Sr. No. Jouranls atricles as compulsary readings (specific articles, Complete reference)

5 http://jac.oxfordjournals.org/cgi/content/full/44/1/139a

6 http://jac.oxfordjournals.org/cgi/content/full/65/8/1646

Relevant Websites

Sr. No. Web adress (only if relevant to the courses) Salient Features

7 http://www.google.co.in/#hl=en&q=pharmaceutical+micrbiology+journal&aq=&aqi related to the antimicrobial succesptibility test recent approach


=&aql=&oq=pharmaceutical+micrbiology+journal&gs_rfai=&fp=ed0c85d743f4616
8 http://www.bionewsonline.com/b/b_medical_and_pharmaceutical_microbiology.ht Related to new drugs research and application
m
9 http://www.mrctechnology.org/commercial-opportunities/funding-translation related to pharma R & D and funding availability through gov. of india

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Detailed Plan For Lectures
Pedagogical tool
Chapters/Sections of
Homework to be Demonstration/case
Week No. Lecture No. Topic Textbook/other
Assigned to students study/images/anmation
reference
ctc. planned

Part 1
Week 1 Lecture 1 Antibiotics and chemotherapeutic agents ->Reference :1,ch13 page 219 NIL

Lecture 2 Types of Antibiotics and chemotherapeutic agents ->Reference :1,ch13 page 219 NIL

Lecture 3 Antifungal antibiotics ->Reference :1,ch13 page 219 Term Paper 1 Allocation NIL

Lecture 4 antitumor substances, ->Reference :1,ch13 page 219 NIL

Week 2 Lecture 5 anti viral agents ->Reference :7, NIL


->Reference :1,ch5 page 79
Lecture 6 anti protozoal and anti helminthes agents ->Reference :1,ch-6 page 99 HomeWork 1 Allocation NIL

Lecture 7 Chemical disinfectants and antiseptics ->Reference :1,ch13 page 219 NIL

Lecture 8 Mechanism of action of antibiotics ->Reference :1,ch13 page 219 HomeWork 1 Allocation images
((http://www.biology.ed.a
c.uk/research/groups/jde
acon/microbes/penicill.ht
m)

Week 3 Lecture 9 (inhibitors of cell wall synthesis ->Reference :8, images


->Reference :1,ch13 page 219 ((http://www.biology.ed.a
c.uk/research/groups/jde
acon/microbes/penicill.ht
m)
Lecture 10 nucleic acid and protein synthesis). ->Reference :1,ch14page 230 NIL

Lecture 11 Bacterial resistance to antibiotics. ->Reference :5, images


->Reference :1,ch14page 230 (http://www.biology.ed.a
c.uk/research/groups/jde
acon/microbes/penicill.ht
m

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Part 1
Week 3 Lecture 12 Molecular principles of drug targeting ->Reference :6, NIL
->Reference :1,ch13 page 219

Week 4 Lecture 13 Drug delivery system in gene therapy ->Reference :1,ch 5 page 59 NIL

Part 2
Week 4 Lecture 14 Mode of action of non antibiotic antimicrobial agents ->Reference :1,ch 5 page 59 NIL

Lecture 15 Penetrating defenses ->Reference :1,ch 5 page 59 HomeWork 1 animation


Submission (http://student.ccbcmd.ed
u/courses/bio141/lecguid
e/unit2/bacpath/invas.ht
ml)
Lecture 16 How the antimicrobial agents reach the targets ->Reference :1,ch 5 page 59 HomeWork 2 Allocation NIL

Week 5 Lecture 17 cellular permeability barrier ->Reference :1,ch 5 page 59 NIL

Lecture 18 cellular transport system ->Reference :1,ch 13page 219 NIL

Lecture 19 and drug diffusion ->Reference :1,ch 13page 219 NIL


->Reference :2,chp 2 page 13
Lecture 20 Microbial contamination ->Reference :1,ch 16page 262 NIL

Week 6 Lecture 21 spoilage ->Reference :1,ch 16page 262 NIL

Lecture 22 pharmaceutical products ->Reference :5, NIL


->Reference :1,ch19 page 323
Lecture 23 sterile injectibles, ->Reference :1,ch19 page 323 NIL

Lecture 24 non injectibles, ->Reference :1,ch19 page 323 HomeWork 2 NIL


Submission

Week 7 Lecture 25 ophthalmic preparations ->Reference :1,ch19 page 323 NIL

Lecture 26 implants) ->Reference :1,ch19 page 323 NIL

Lecture 27 and their sterilization.D value ->Reference :1,ch19 page 323 NIL

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Part 2
Week 7 Lecture 28 Z value. ->Reference :1,ch 20 page 345 NIL

MID-TERM
Part 3
Week 8 Lecture 29 Immobilization ->Reference :1,ch 24 page 424 images
(http://www.rikenresearch
.riken.jp/eng/frontline/506
0)
Lecture 30 procedures for pharmaceutical applications ->Reference :1,ch 24 page 424 NIL

Lecture 31 liposomes ->Reference :1,ch4 page 50 NIL

Lecture 32 Macromolecular, ->Reference :1,ch 24 page 42 NIL

Week 9 Lecture 33 cellular drug carriers ->Reference :1,ch 10 page 150 HomeWork 3 Allocation NIL

Lecture 34 synthetic drug carriers ->Reference :1,ch 10 page 150 NIL

Lecture 35 Financing R&D capital ->Reference :9, NIL

Lecture 36 market outlook ->Reference :9, NIL

Week 10 Lecture 37 IP, BP, USP. ->Reference :9, NIL

Lecture 38 Government regulatory practices ->Reference :4,ch 28 page 856 NIL


->Reference :9,
Lecture 39 policies ( Government regulatory) ->Reference :4,ch 28 page 856 HomeWork 3 NIL
Submission
Part 4
Week 10 Lecture 40 FDA perspective ->Reference :4,ch 28 page 856 HomeWork 4 Allocation NIL

Week 11 Lecture 41 Reimbursement of drugs ->Reference :4,ch 28 page 856 NIL

Lecture 42 and biologicals, ->Reference :4,ch 28 page 856 NIL

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Part 4
Week 11 Lecture 43 legislative perspective. ->Reference :4,ch 28 page 856 NIL

Lecture 44 Rational drug design. ->Reference :4,ch 28 page 856 NIL

Week 12 Lecture 45 Biosensors in pharmaceuticals ->Reference :1,1ch 16page HomeWork 4 NIL


262 Submission

Lecture 46 Application of microbial enzymes in pharmaceuticals ->Reference :1,ch 25 page 440 NIL

Lecture 47 Legal protection for biotechnology ->Reference :1,ch24 page 414 NIL

Lecture 48 Patent, company secrecy) marketing a biotechnological invention ->Reference :1,ch24 page 414 Term Paper 1 NIL
Submission

Week 13 Lecture 49 Good Laboratory Practices (GLP) in pharmaceutical industry. ->Reference :4,ch 28 page 856 NIL

Lecture 50 Regulatory aspects of quality control ->Reference :1,Quality NIL


assurance
Lecture 51 Quality assurance and quality management in pharmaceuticals ->Reference :1,ch 16 page 277 NIL
->Reference :3,page 121
Lecture 52 ISO, WHO and US certification ->Reference :4,ch 28 page 856 NIL

Spill Over
Week 14 Lecture 53 Patent, company secrecy) marketing a biotechnological invention NIL

Lecture 54 Application of microbial enzymes in pharmaceuticals ->Reference :1,ch 25 page 440 NIL

Lecture 55 Government regulatory practices ->Reference :4,ch 28 page 856 NIL

Lecture 56 Quality assurance and quality management in pharmaceuticals ->Reference :1,Quality NIL
assurance

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Details of homework and case studies plan
Nature of homework
Homework No. Topic of the Homework (group/individuals/field work

Homework 1 Mechanism of action of antibiotics (inhibitors of cell wall synthesis, nucleic acid and protein Individual
synthesis). Bacterial resistance to antibiotics.

Homework 2 Mode of action of non antibiotic antimicrobial agents. Penetrating defenses How the antimicrobial Individual
agents reach the targets (cellular permeability barrier, cellular transport system and drug
diffusion).

Homework 3 Immobilization procedures for pharmaceutical applications (liposomes). Macromolecular, cellular Individual
and synthetic drug carriers

Homework 4 Government regulatory practices and policies, FDA perspective.Reimbursement of drugs and Individual
biologicals, legislative perspective. Rational drug design.
*Normally all the homeworks shall be submitted online but in special courses where homeworks cannot be submited online , the insructor can edit the mode of submission while
entering the IP Details

Scheme for CA:out of 100*


Component Frequency Out of (If any) Marks for each Total Marks

Homework 3 4 15 45

Term Paper 1 25 25

Lab Assesment 30 30

Total :- 100

* In ENG courses wherever the total exceeds 100, consider x best out of y components of CA, as explained in teacher's guide available on the UMS

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List of suggested topics for term paper[at least 15] (Student to spend about 15 hrs on any one specified term paper)
Sr. No. Topic
1 Antibiotics and chemotherapeutic agents:
2 Antifungal antibiotics and antitumor substances
3 Molecular principles of drug targeting.
4 Drug delivery system in gene therapy
5 The antimicrobial agents reach to the targets (cellular permeability barrier, cellular transport system and drug
diffusion
6 Microbial contamination and spoilage of pharmaceutical products
7 Immobilization procedures for pharmaceutical applications
8 cellular and synthetic drug carriers
9 Financing R&D capital and market outlook. IP, BP, USP
10 Government regulatory practices and policies
11 Biosensors in pharmaceuticals
12 Application of microbial enzymes in pharmaceuticals
13 Quality assurance and quality management in pharmaceuticals ISO, WHO and US certification.
14 Good Laboratory Practices (GLP) in pharmaceutical industry.
15 Chemical disinfectants and antiseptics

*Each experiment of the lab will be evaluated using following relative scheme:

Component % of Marks

J/E 20

WR 50

VIVA 30

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List of experiments :-

Expt. No Title Equipment Used Reference of Lab manual

Before Mid-Term

lab based 1 Bioassay of chloremphenicol by laminar, hot air oven ,imcubator, autoclave
plate assay method or colrimeter colony counter
turbidiometric Assay method.
lab based 2 To determine MIC, MBC of laminar, hot air oven ,imcubator, autoclave
anitibiotics
lab based 3 Sampling of pharmaceuticals for laminar, hot air oven ,imcubator, autoclave
microbial contamination and load
.Suspensions cont....
lab based 4 creams and ointments etc laminar, hot air oven ,imcubator, autoclave

lab based 5 Determination of D value, Z value laminar, hot air oven ,imcubator, autoclave
for heat sterilization in
pharmaceuticals.
lab based 6 Determination of antimicrobial laminar, hot air oven ,imcubator, autoclave
activity of a chemical compound.
After Mid-Term

lab based 7 Determination of phenol co laminar, hot air oven ,imcubator, autoclave
efficient
lab based 8 To perform the In-use test laminar, hot air oven ,imcubator, autoclave

lab based 9 Bioassay of chloremphenicol by laminar, hot air oven ,imcubator, autoclave
plate assay method or
turbidiometric Assay method.
lab based 10 MBC of anitibiotics laminar, hot air oven ,imcubator, autoclave

lab based 11 Determination of D value, Z value laminar, hot air oven ,imcubator, autoclave
for heat sterilization in
pharmaceuticals
Spill Over

lab based 12 Determination of phenol co laminar, hot air oven ,imcubator, autoclave
efficient

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lab based 13 To perform the In-use test laminar, hot air oven ,imcubator, autoclave

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