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Electric smoking system

There are various types of heat-not-burn products.[notes 1][15] There are heat-not-burn tobacco products (heated tobacco products) that heat up tobacco using a battery-powered
heating system.[12] As it starts to heat the tobacco, it generates an aerosol that contains nicotine and other chemicals, that is inhaled.[12] They also generate smoke.[16] Gases, liquid
and solid particles, and tar are found in the emissions.[16] They contain nicotine, which is the reason these products are addictive.[12] They also contain additives not found in
tobacco, and are frequently flavored.[12] It heats tobacco leaves at a lower temperature than traditional cigarettes,[31] which is about 250–350 °C (around 500 °F.[32]).[9] These
products provide some of the behavioral aspects of smoking.[33] There are different types of heat-not-burn tobacco products.[34] One type uses an embedded heat source; another
type uses an external heat source; another one uses a heated sealed chamber; to deliver nicotine using tobacco leaf.[34] Some use product-specific customized cigarettes.[12] Without
using an electrically controlled heating system, there is a device that uses a carbon heat source that, once lit, passes heat to a processed tobacco plug.[35] There are devices that use
cannabis.[36] They are not electronic cigarettes.[12] They can overlap with e-cigarettes such as a combination of an e-cigarette and a heat-not-burn tobacco product, for the use of
tobacco or e-liquid.[34]

A 2016 World Health Organization report found no compelling evidence has been presented for the claims of lowered risk or health benefits compared with traditional cigarettes,
which are based on industry-funded research for these products.[37] A 2018 Public Health England report states that the evidence indicates that heat-not-burn tobacco products may
be much safer than traditional cigarettes but less safe than e-cigarettes.[38] The aerosol contains levels of nicotine and cancer-causing chemicals comparable to regular cigarettes.[2]
Another source found, some of the substances inhaled from using these products are carcinogens.[39] Although heat-not-burn tobacco products are probably less dangerous than
smoking, it would be better for smokers to completely stop, according to the Committee on Toxicity.[39] There is a lack of evidence on the possible effects of second-hand exposure.
[12]
The limited evidence on air emissions from the use of heat-not-burn tobacco products indicates that toxic exposure from these products is greater than that of e-cigarettes.[40]
There is insufficient evidence on the efficacy of such products on quitting smoking.[31]

As early as the 1960s, the tobacco companies developed alternative tobacco products with the goal of supplementing the cigarette market with products.[41] Heat-not-burn tobacco
products first came to market in 1988, however they were not a commercial success.[32] There has been a global decline in tobacco consumption that, if continued, will negatively
impact the tobacco industry's profits.[41] This decline led the industry to invent and market new products, such as heat-not-burn tobacco products.[41] Smokers regularly reported
heat-not-burn tobacco product use to be less satisfying than smoking a cigarette.[40] These products have been introduced by large tobacco companies.[42] The introduction of the
latest generation of heat-not-burn tobacco products appears to be the latest chapter in the decades-old tobacco industry strategy of working to create partnerships with governments
and health advocates, presenting these alleged 'harm reduction' products as an option to address the tobacco epidemic.[41] Current smoking bans may not have been extended to
include such products.[43]

Contents
Health effects
Emissions
Addiction and quitting
Nicotine yield
Pregnancy
Construction
History
Products
eTron 3T
Firefly vaporizers
glo products
IQOS
iSmoke OneHitter
IUOC 2
lil
Mok
Pax vaporizers
Ploom vaporizers
Pulze
TEEPS
V2 Pro products
Comparison to mainstream smoke of traditional cigarettes
Prevalence
Marketing
Regulation
Notes
Bibliography
References
External links

Health effects
A 2016 Cochrane review found that it was unclear whether using heat-not-burn tobacco products instead of traditional cigarettes would "substantially alter the risk of harm".[18] As
of December 2017, it is impossible to quantify the health risk from using these products.[39] There is very limited information available on their health effects[39] and the available
research on their harmfulness is limited.[22] It is not clear what the adverse effects are in the short-term.[44] The long-term effects are unclear.[44] There is a lack of long-term studies.
[9]
Studies over one year on the effects of exposure to heat-not-burn tobacco products have not been conducted, as of 2019.[45]

There are different kinds of heat-not-burn tobacco products available and therefore the effects each kind produces will vary.[46] This creates a challenge for researchers.[46] It is not
known how users evaluate the safety of these products.[47] Among those who have tried such products, approximately 50% believe they are safer than traditional cigarettes and the
other 50% believe they are just as unsafe as traditional cigarettes.[47]
A 2016 World Health Organization report stated claims of lowered risk or health benefits for heat-not-burn tobacco products compared
with traditional cigarettes are based on industry-funded research, but compelling independent research is not available to support these
claims.[37] Studies on human use were wide-ranging and largely affiliated with the manufacturers, as of 2018.[5] Action on Smoking and
Health in the UK stated in 2016 that due to "the tobacco industry's long record of deceit" regarding the health risks involving smoking, it
is important to conduct independent studies into the health effects of these products.[48]

With an assorted range of electronic cigarettes devices in the UK, it is unclear whether heat-not-burn tobacco products will offer any
favorable benefit as another plausible harm reduction product.[38] A 2016 World Health Organization reported noted that some scientists E-cigarette emissions machine with
believe that heat-not-burn tobacco products to be as dangerous as traditional cigarettes.[37] A 2018 Public Health England report states heat-not-burn tobacco products.[9]
The emissions of four heat-not-burn
that the evidence indicates that heat-not-burn tobacco products may be much safer than traditional cigarettes but less safe than
tobacco products can be generated
e-cigarettes.[38] Although heat-not-burn tobacco products are probably less dangerous than smoking, it would be better for smokers to
in parallel in an emissions
completely stop, according to the Committee on Toxicity in 2017.[39] experiment.[9] The emissions
generated are analyzed using
appropriate analytical techniques,
Emissions which allows a comparison of
The aerosol contains levels of nicotine and cancer-causing chemicals comparable to regular cigarettes.[2] They contain comparable levels different applications and products.
[9]
of many volatile organic compounds and greater amounts of the polycyclic aromatic hydrocarbon acenaphthene than regular cigarettes.
[49]
The substances in the emissions of traditional cigarettes such as tar, nicotine, carbonyl compounds (including acetaldehyde, acrolein,
and formaldehyde), and nitrosamines are also found in emissions of heat-not-burn tobacco products.[8] A 2017 study found a 10% rise in
carbon monoxide and formaldehyde air levels than compared to the background during heat-not-burn tobacco product use.[24] A 2017 study found heat-not-burn tobacco products
generated emissions of particulate metals and organic compounds as well as aldehydes.[24] Research suggests that heat-not-burn tobacco products generate less concentrations of
airborne contaminates in indoor places in comparison to a traditional cigarette.[24] Indoor air quality is reduced from the use of heat-not-burn tobacco products.[45]

A 2018 Public Health England report found "Compared with cigarettes, heated tobacco products are likely to expose users and bystanders to lower levels of particulate matter and
harmful and potentially harmful compounds (HPHC). The extent of the reduction found varies between studies."[46] They also noted that the evidence indicates that the levels of
nicotine inhaled from heat-not-burn tobacco products is less than that of cigarette smoke.[50] Exposure to mutagenic and other harmful substances is lower than with traditional
cigarettes.[9] However, reduced exposure to harmful substances does not mean that health risks are equally reduced.[9] Even low exposure increases the risks for cancers, stroke, and
other cardiovascular diseases compared to non-smokers.[9] It is still unclear to what extent the reduced levels lead to lowered health risks.[9] Lower levels of harmful emissions has
been shown, but lowering the risk to the smoker who transitions to using them has not been shown, as of 2018.[16] Heat-not-burn tobacco products do not reduce being exposed to
nicotine or the risk for the potential addiction to nicotine, according to the Committee on Toxicity in 2017.[39] Some of the substances inhaled from using these products are
carcinogens.[39]

The physiological changes, such as inflammation in multiple organ systems, energy metabolism, and carcinogenesis, in responses to heat-not-burn tobacco emissions has not been
well characterized due to limited research in this area, especially in animal models.[31] A 2018 in vitro study suggested a less harmful pathophysiological response in human
organotypic oral epithelial cultures when exposed to such emissions.[31] A 2016 animal study showed that heat-not-burn tobacco emissions did not increase surfactant lipids,
surfactant proteins, surfactant metabolizing proteins, inflammatory eicosanoids and their metabolic enzymes, and several ceramide classes, compared with tobacco cigarette smoke-
exposed mice.[31] A 2016 study found that even with reduced toxicants in heat-not-burn tobacco emissions, overuse (40 tobacco sticks per day) can still lead to eosinophilic
pneumonia in humans.[31]

The impact on the overall population is unclear.[44] Studies on heat-not-burn second-hand emissions were diverse and largely affiliated with the manufacturers, as of 2018.[5] There
is disagreement to the extent to which heat-not-burn tobacco products generate air emissions.[51] There is also disagreement regarding the composition of the emissions.[51] There is
a lack of evidence on the possible effects of second-hand exposure.[12] There is anticipated to be a reduced risk to bystanders where smokers were using heat-not-burn tobacco
products instead of smoking.[39] The limited evidence on air emissions from the use of heat-not-burn tobacco products indicates that toxic exposure from these products is greater
than that of e-cigarettes.[40]

Addiction and quitting


They contain nicotine, which is the reason these products are addictive.[12] The nicotine content in the emissions of heat-not-burn tobacco products is in the same range as the
nicotine emissions of traditional cigarettes, which suggests a similar addictiveness and dependence potential.[9] There is insufficient evidence on the efficacy of heat-not-burn
tobacco products on quitting smoking.[31]

A 2018 World Health Organization report states that "Conclusions cannot yet be drawn about their ability to assist with quitting smoking (cessation), their potential to attract new
youth tobacco users (gateway effect), or the interaction in dual use with other conventional tobacco products and e-cigarettes."[12] In 2017, Ministry of Health in New Zealand stated
"There is limited information on product use, including whether smokers are likely to switch completely from tobacco smoking or use both types of product, as well as initiation by
non-smokers (including young people)."[52] In 2017, the Committee on Toxicity stated "The Committees were concerned over the potential for non-smokers including children and
young people, who would not otherwise start to smoke cigarettes, to take up using these products as they are not without risk."[53] Compared to not using heat-not-burn tobacco
products, there is an increase in risk for non-smokers who begin using them.[53] It is possible that these products could appeal to non-smokers, especially since they are available in
various flavors.[22] A growing body of evidence shows that never-users of tobacco products, especially children and adolescents, could be susceptible to new products and that this
could result in later use of traditional cigarettes.[2] In 2017, the Committee on Toxicity "Committees were particularly concerned for young people, who do not smoke, starting to use
these products, due to the potential for longer exposure over the remainder of their lives compared to adults and to possible differences in sensitivity."[53]

They are commonly used instead of or along with combustible tobacco products.[47] Dual use among heat-not-burn tobacco regular users with combustible products is common.[54]
Trying a heat-not burn-tobacco product was more frequent among adults below the age of 30 and regular traditional cigarette users.[55] A 2015 online survey found 6.6% of 8240
respondents had tried a heat-not-burn tobacco product at least once.[56] Research demonstrated that users of heat-not-burn tobacco products is greater among women who smoke.
[47]
10 to 45% of non-smokers use these products, according to 4 epidemiological papers.[16] This shows the effectiveness of the marketing of the tobacco industry.[16] In this regard,
the IQOS is more a gateway to traditional cigarette use (20% of users) than quitting (11% of users).[16] Further, it is not anticipated to have a lowered risk among dual users who
make up the remaining 69%.[16] In 2016 Philip Morris International acknowledged that the IQOS product is probably as addictive as tobacco smoking.[48] IQOS is sold with a
warning that states the best option is to avoid tobacco use altogether.[57]

As of July 2017, not many US adults had tried using a heat-not-burn tobacco product.[55] As of July 2017, approximately one in 20 US adults have heard of heat-not burn-tobacco
products.[55] This includes one in ten traditional cigarette users.[55] Use in Italy was 1.4% among the people and 3.1% among regular tobacco users.[47] A 2018 survey in Italy found
that 45% of those who experimented with the IQOS product were never-smokers.[16] The same survey found 51% of those interested in the IQOS product were never-smokers.[16]
Therefore, such a product may represent, at least in Italy, a gateway for nicotine addiction among never-smokers rather than a harm reduction substitution for current smokers.[58]
In Germany, heat-not-burn tobacco product use is not common and is generally more frequent among smokers who have been educated longer and who make more money.[47] Use
in Japan, where that have been sold since 2014, is much higher.[47] A 2017 survey in Japan found that of those who used the IQOS product within the last month, 20% were never-
smokers.[16] These products did not satisfy 86% of users, and they did not quit using traditional cigarettes; they used both, according to a 2017 survey in Japan.[16]

Nicotine yield
The limited data on heat-not-burn tobacco product users show that they take short puffs, and that the time between puffs is very short.[16] Experimental tests show that there is a
higher volume of puffs at shorter intervals than with traditional cigarettes.[16] A 2018 clinical trial found that tests of smokers switching to an IQOS product showed a tendency to
take more puffs at shorter intervals.[16]

Users experience blood nicotine levels reaching a peak at about 6 to 7 minutes for both a heat-not-burn tobacco product and a traditional cigarette.[16] The IQOS product delivers
slightly less blood nicotine overall than a traditional cigarette, but a higher amount than a nicotine gum.[16] A 2016 study found that smokers were less satisfied and had a lower
reduction in cravings with using an IQOS product than with traditional cigarettes.[16] In 2016, smoking trial volunteers switching to a heat-not-burn tobacco product, after an initial
adjustment period, usually smoked more traditional cigarettes than those not switching, while reporting that they were less satisfying and rewarding than with regular cigarettes.[16]

Sharper peaks in blood nicotine levels from inhalation causes greater nicotine dependence than oral consumption.[59] Nicotine replacement products, for instance, deliver nicotine in
a slow, stable manner, and are thus less addictive.[59] Inhaling nicotine reaches the blood quicker than oral consumption.[59] Blood nicotine levels drop fairly quickly, halving every 1
to 2 hours.[59] Nicotine withdrawal causes deteriorating mood, driving craving for nicotine consumption.[59]

Pregnancy
Pregnant women who wish to quit smoking but are unable, are left with few options.[58] As nicotine replacement products is often ineffective for quitting smoking, pregnant women
turn to alternatives such as heat-not-burn tobacco.[31] There is no information available on potential impact of maternal inhalation of heat-not-burn tobacco emissions during
pregnancy on fetal outcomes, as of 2018.[31] The risk to the fetus from heat-not-burn tobacco products during pregnancy is hard to quantify.[39] Although the risk to the fetus is
probably less than smoking during pregnancy, the Committee on Toxicity recommends to completely stop smoking.[39] Nicotine is harmful to the infant and the growing adolescent
brain.[2] Nicotine is metabolized much faster while a women is pregnant and with ease goes through the placental barrier, and collects in breast milk.[59] Further, there is growing
evidence that nicotine exposure during pregnancy is linked to early birth, stillbirth, and abnormal brain growth.[59] Nicotine may result in adverse effects to the neurological growth
of the fetus.[60]

Nicotine can lead to vasoconstriction of uteroplacental vessels, reducing the delivery of both nutrients and oxygen to the fetus.[31] As a result, nutrition is re-distributed to prioritize
vital organs, such as the heart and the brain, at the cost of less vital organs, such as the liver, kidneys, adrenal glands, and pancreas, leading to underdevelopment and functional
disorders later in life.[31] Animal research using maternal nicotine exposure showed a direct adverse impact on pancreas development by reducing endocrine pancreatic islet size and
number.[31] This was accompanied by a decrease in gene expression of specific transcription factors and blood glucose regulating hormones such as insulin and glucagon.[31] As a
result, rats exhibited significant pancreatic dysfunction and glucose intolerance.[31] Moreover, several animal studies have reported insulin resistance in adult offspring due to
maternal nicotine exposure.[31] In animal models, nicotine has also been shown to activate nicotine acetylcholine receptors (nAChR) in the brain, which are important in regulating
brain development.[31] Nicotine exposure during the first trimester of pregnancy (2 mg/kg/d) leads to structural changes in the hippocampus and somatosensory cortex in rats.[31]

Construction

Tobacco stick; above, disassembled, below, intact.[9] A: Reconstituted


tobacco film, made of dried tobacco suspension.[9] 70% tobacco,
humectants (water and glycerin) to encourage aerosol formation, binding
agents, and aroma agents.[9] B: Hollow acetate tube.[9] C: Polymer film
filter cools the aerosol.[9] D: Soft cellulose acetate mouthpiece, which
mimics the feel of a traditional cigarette.[9]

Nicotine is released from tobacco heated above 150 °C.[61] Combustible tobacco cigarettes reach about 900 °C during a puff and smoulder at about 400 °C between puffs.[17] The
burning process, substances emitted and their levels vary at different temperatures.[17] Distillation, the process during which nicotine and aromas are transferred from tobacco to
smoke, occurs below 300 °C; pyrolysis occurs at about 300 °C–700 °C, entails the decomposition of biopolymers, proteins, and other organic materials and generates the majority of
substances emitted in smoke; and combustion occurs above 750 °C and results in the generation of carbon dioxide, carbon monoxide, and water.[17] The temperature the tobacco
reaches greatly varies among heat-not-burn tobacco products.[39] It depends on the process used to heat the tobacco.[39] HeatSticks are heated to a maximum of 350 °C, a
temperature sufficient to enable pyrolytic decomposition of some organic materials,[17] while the glo iFuse heats tobacco to around 35 °C.[16] Formation of toxic volatile organic
compounds, including formaldehyde, acetaldehyde and acrolein, via dehydration and oxidation of the humectants, propylene glycol and glycerin, have been reported in e-cigarette
aerosols at similar temperatures as IQOS.[17] In addition, flavoring chemicals in e-cigarettes undergo thermal degradation and contribute significantly to levels of toxic aldehydes
emitted in e-cigarette aerosol.[17] Carbon monoxide (CO), nitrogen oxides, soot or tars, and aldehydes in the emissions demonstrate that these products undergo thermal
degradation.[16] The solids in the emissions have been called nicotine-free dry particulate matter rather than tar in papers written by people connected to the tobacco industry.[16]
Gases, liquid and solid particles are also found in the emissions.[16]

Since the constituents of HeatSticks may be different from that of combustible cigarettes, including flavorants and additives, it is plausible that the IQOS aerosol may contain
substances not present in tobacco smoke.[17] The emissions of the IQOS HeatSticks and the IQOS menthol mini-cigarettes contains about three times the amount of water and about
half the amount of tar found in the emissions of traditional cigarettes.[16] The IQOS HeatSticks do not generate a flame, they are charred following use.[62] Heat-not-burn tobacco
products including IQOS generate smoke.[16] Up until 2016, Phillip Morris International researchers stated their IQOS product produces smoke.[16]

The heat-not-burn tobacco product consists of 3 components with different functions.[9] These include the tobacco stick with processed tobacco, a pen-like heater (holder), in which
the tobacco stick is inserted, which is then heated by means of an electrically controlled heating element, and a charger (the charger), which recharges the heater after use.[9] The
heat-not-burn tobacco products automatically stops the heating process after 6 minutes or 14 moves, so that pyrolysis products and pollutant release are limited in time as well as by
a maximum number of puffs per stick.[9] Heat-not-burn tobacco products may not generate side-stream smoke because they do not fully combust, but the temperatures reached are
sufficient for pyrolytic reactions to happen.[8] There are devices that demonstrate pyrolysis or combustion, but research has not determined whether it is pyrolysis or combustion.[16]
The tobacco stick contains a compressed tobacco film as well as several filter elements.[9] The tobacco film consists of a dried tobacco suspension that has been rolled up into a
paper-thin brown tobacco foil.[9] This consists of about 70% tobacco as well as humectants, binders and flavorings.[9] Water and glycerin are used as humectants to prevent drying
out and to promote aerosol formation upon heating.[9] The filter elements consist of 2 independent systems: A polymer film filter that cools the aerosol, followed by a soft cellulose
acetate mouthpiece filter that mimics the sensory aspects of a traditional cigarette.[9]

Heat-not-burn tobacco products are a battery-powered systems that produce nicotine-containing emissions by heating tobacco.[9] For
this purpose, tobacco sticks are placed in a corresponding heater and heated to about 250–350 °C (around 500 °F.[32]).[9] This results in
nicotine-containing emissions, which are inhaled via a mouthpiece with a filter segment.[9] They are hybrids between electronic and
conventional cigarettes: on one hand, they are equipped with a device that heats the product, without reaching combustion, to generate
aerosol (i.e., a sort of "cold smoke"); on the other hand, the product used is not a liquid containing nicotine, but "real" tobacco.[58] There
are products that have a time limit, so that the user is forced to inhale the nicotine within 3.5 minutes to 10 minutes prior to the device
turning off.[16] This function helps support peaks of blood nicotine, resulting in an increased nicotine dependence.[16]

There are three general types of heat-not-burn tobacco products.[39] One immediately heats processed tobacco to generate aerosol.[39] Tobacco film (right side) following
Another uses processed tobacco that is heated in an aerosol.[39] Then there are ones where the aerosol goes over processed tobacco to give use.
a flavor to the aerosol.[39] Heat-not-burn tobacco products heat tobacco leaves at a lower temperature than traditional cigarettes.[31] Heat-
not-burn tobacco products usually heat up tobacco, rather than use liquids.[63] In contrast, e-cigarettes heat liquids that can contain
nicotine.[29] Another type of heat-not-burn tobacco product is the loose-leaf tobacco vaporizer that entails putting loose-leaf tobacco into a chamber, which is electrically heated
using an element.[28] Some use product-specific customized cigarettes.[12] There are devices that use cannabis.[36] They are not e-cigarettes.[12] They can overlap with e-cigarettes such
as combining an e-cigarette and a heat-not-burn tobacco product, for using tobacco or e-liquid.[34]

History
As early as the 1960s, the tobacco companies developed alternative tobacco products with the goal of supplementing the cigarette market
with products.[41] The first commercial heat-not-burn tobacco product was the R. J. Reynolds Premier,[64] a smokeless cigarette launched in
1988 and described as difficult to use.[25] Many smokers disliked the taste.[65] It was shaped like a traditional cigarette, and when heated the
smoldered charcoal moved past processed tobacco containing more than 50 percent glycerin to create an aerosol of nicotine.[66] It did
require some combustion.[67] In 1989,[68] after spending $325 million,[69] R. J. Reynolds pulled it from the market months later after the
American Medical Association and other organizations recommended to the US Food and Drug Administration (FDA) to restrict it or
classify it as a drug.[70]
Steam Hot One, a Japanese
The Premier product concept went on to be further developed and re-launched as Eclipse[68] in the mid-1990s,[71] and was available in variant of the Eclipse made by
[72] [68]
limited distribution as of 2015. Eclipse was promoted using viral marketing. Reynolds American stated that the Revo was a Japan Tobacco.
"repositioning" of its Eclipse.[73] R. J. Reynolds' Revo was withdrawn in 2015.[72]

In October 1998, Philip Morris launched the Accord in the US.[19] A specialized cigarette was designed to be used with the electric heating
system.[19] Also in 1998, the company launched Accord in Osaka, Japan, calling it Oasis.[19] The battery-powered product was the size of a
pager.[74] The product was marketed as "low-smoke".[19] Advertisements stating reduced risk were drafted for Accord in the US, but were
never released.[19] An attempt was made in 2007 by Kenneth Podraza, who was the Vice President of Research and Development at Philip
Morris in the US, to get the Surgeon General of the United States to endorse it.[19] It has not been shown that the Surgeon General replied to
Podraza's letter.[19] Few people started using the Accord, and most users also continued to use traditional cigarettes.[19] The Accord ceased Philip Morris' Heatbar pictured
production in 2006, eight years after it came on the market.[19] without a specifically designed
cigarette.
In 2007 Philip Morris International launched Heatbar,[75] which was very similar to the Accord.[19] The Heatbar was around the size of a
mobile phone and was said to heat specifically designed cigarettes rather than burning them.[76] The only benefit was to lower second-hand
smoke, which led to Heatbar being discontinued.[77] Heatbar did not obtain any significant user reception.[78] Accord and Heatbar are predecessors of Philip Morris International's
current heat-not-burn tobacco products.[79] Heat-not-burn tobacco products were not a commercial success, and most of them were quickly taken off the market following their
debut.[32]

In years leading up to 2018, increased tobacco control measures have directed the tobacco industry to develop alternative tobacco products, such as heat-not-burn tobacco products.
[9]
There has been a global decline in tobacco consumption that, if continued, will negatively impact the tobacco industry's profits.[41] This decline led the industry to invent and
market new products, such as heat-not-burn tobacco products.[41] The introduction of these heat-not-burn tobacco products may also have been a response to the growing
popularity of e-cigarettes beginning around 2007 after independent companies introduced them before the major multinational tobacco companies entered the e-cigarettes market.
[41]
Furthermore, the global decline of cigarette consumption and decrease in adult smoking prevalence (from 24% in 2007 to 21% in 2015), combined with the success of tobacco
control, including implementation of the WHO Framework Convention on Tobacco Control, may also have led the tobacco companies to consider alternative products to protect
their profits and political interests.[41] The ubiquitousness of e-cigarettes and growing dissatisfaction with not providing a throat-hit may present an opportunity for heat-not-burn
tobacco products.[32] These products have been introduced by large tobacco companies.[42] They are developed by several tobacco companies.[80] Philip Morris International
anticipates a future without traditional cigarettes, but campaigners and industry analysts call into question the probability of traditional cigarettes being dissolved, by either
e-cigarettes or other products like IQOS.[81]

Products

Heat-not-burn tobacco system. a) Charger (left) and holder (right), b) Tobacco stick (left) and holder with tobacco
stick inserted (right), c) Disassembled holder, with heating element visible (left) and the holder's lid (right).[9]
The products use a heating system where the tobacco is heated and aerosolized.[12] In addition to nicotine, they contain additives not derived from tobacco, and are frequently
flavored.[12] The evidence indicates that the concentrations of nicotine in mainstream heat-not-burn tobacco products aerosol are less than what is found in cigarette smoke.[50]
Smokers regularly reported heat-not-burn tobacco product use to be less satisfying than smoking a cigarette.[40] The heat-not-burn tobacco products that were tested provided more
nicotine in the aerosol than a cigalike e-cigarette but not as much nicotine compared with a tank style e-cigarette.[40] They are designed to be similar to their combustible
counterparts[82] and they provide some of the behavioral aspects of smoking.[33] These products replicate the oral inhalation and exhalation, taste, rapid systemic delivery of
nicotine, hand-to-mouth feel and throat hit sensations (depending on the temperature) that are similar to smoking traditional cigarettes.[31] Heat-not-burn products aim for a niche
between combustible tobacco smoking and e-cigarettes that aerosolize nicotine suspended in humectants.[5] There are different types of heat-not-burn tobacco products in the
marketplace.[15] Some examples include products that use tobacco sticks such as glo and IQOS, or products that use loose-leaf tobacco such as Pax and Ploom.[12]

eTron 3T
The eTron 3T was initially launched as a disposable e-cigarette by Vapor Tobacco Manufacturing in December 2014.[83] The product
employs a patented system whereby tobacco is ground and used to make a water-based extract.[84] The liquid and tobacco extract is
mixed with glycerin and aerosolized by an electronic heating system.[84] Their organic liquids are made from organic tobacco, organic
glycerin, and water.[83] They are sold in 15 ml bottles.[85] The heat-not-burn device uses nicotine and tobacco.[86] The taste is similar to
tobacco, according to the company.[83] They also sell rechargeable e-cigarettes that contain the patented tobacco extract.[86]

Firefly vaporizers
The Firefly developed the Firefly 2, which heats loose-leaf plant material and concentrates and is often used to aerosolize cannabis.[15] eTron 3T organic red, gold and
Firefly 2 is more compact than the original Firefly vaporizer.[87] Firefly 2+ can use either dry herbs or extracts.[88] The temperature can be menthol products.
adjusted from 22-500 °F.[88] It uses a patented heating technology.[88] The heating technology heats the device up to the desired
temperature with each puff rather than a preset temperature setting from the beginning.[89]

glo products
In 2016, British American Tobacco launched a battery-powered heat-not-burn product called glo in Japan.[90] It is also sold in South Korea, Switzerland, Russia,[10] and the Ukraine.
[91]
glo uses tobacco sticks called Neostiks in France.[16] It uses a heating element with a tobacco stick,[82] which is described as a mini-cigarette.[16] glo heats up to 240 °C.[16] The
nicotine emissions are approximately 50% less in glo than in IQOS.[45] In May 2017 they released i-glo in Canada.[92] Bonnie Herzog, a senior analyst at Wells Fargo Securities stated
that the proposed acquisition of R. J. Reynolds by British American Tobacco in 2016 would let them catch up in the technology competition.[93] The data on glo is limited.[52] glo is
marketed as being easier to operate than IQOS.[91]

The glo iFuse debuted in Romania by British American Tobacco in 2015.[82] It is referred to as a heat-not-burn device.[94] It uses a cartridge with a tobacco stick and a flavored
nicotine liquid.[82] It is a hybrid of a heat-not-burn tobacco product and an e-cigarette.[17] It consists of a heating element, a liquid tank (like e-cigarettes) and a tobacco cavity
through which the e-cigarette-like aerosol passes and is infused with tobacco flavor.[17] It uses cartridges called Neopods.[16] It heats tobacco to approximately 35 °C.[16] This close to
being unheated tobacco product is unlike heated tobacco products.[16]

IQOS
The introduction of IQOS (/ˈaɪkoʊs/ EYE-kohs[95]) was announced on June 26, 2014.[96] The product is marketed by Philip Morris
International under the Marlboro and Parliament brands.[97] Although it is marketed as a novel product, it is very similar to the "Accord"
product released by the same company in 1998; however, the IQOS sticks have more nicotine, more tar, and less tobacco.[19] They are
heated to a lower temperature, and the kit costs about US$40 more in 2018 dollars.[19]

Initially launched in 2014 in Nagoya, Japan and Milan, Italy, IQOS is being gradually rolled out to other countries.[98] As of April 2019,
IQOS was available in around 44 countries.[99] Philip Morris International has projected that when 30 billions units are sold, IQOS would
increase profits by $700 million.[100] In October 2018, Philip Morris International introduced a less expensive version of IQOS called
IQOS 3 in Tokyo, Japan.[101] The IQOS 3 Multi was also launched, which is capable of multiple consecutive uses.[102] IQOS, consisting of charger, holder,
and tobacco stick.
The IQOS product consists of a charger around the size of a mobile phone and a holder that looks like a pen.[103] The packaging of IQOS is
similar to iPhones and other upscale smartphones.[104] The disposable tobacco stick[105] called HeatSticks or HEETS in some places they
are sold,[106] is described as a mini-cigarette.[16] The sticks contain processed tobacco and has been soaked in propylene glycol.[105] The stick is inserted into the holder which then
heats it to temperatures up to 350 °C.[107] The amount of nicotine provided may be a little strong for light cigarette smokers.[108] The sticks are available in regular, balanced regular,
menthol and mint flavor.[108] Users have reported less smell and odor on clothing.[67] The emissions generated by IQOS contains the identical harmful constituents as tobacco
cigarette smoke, including volatile organic compounds at comparable levels to cigarette smoke, polycyclic aromatic hydrocarbons at vast various ranges, and carbon monoxide.[2] All
of these substances, on the basis of rigorous research of cigarette smoke, are known to cause significant harms to health.[2] A 2017 review found "little research on what substances
are released after the device heats the tobacco-based paste. The physical effects on users are also not yet known."[109] According to Netherlands National Institute for Public Health
and the Environment, IQOS is "harmful to health, but probably less harmful than smoking tobacco cigarettes."[110]
On December 5, 2016,[111] Philip Morris International submitted a multi-million page application[112] to the US FDA for IQOS to be authorized as a modified risk tobacco product.[111]
The advisory panel appointed by the US FDA reviewed Philip Morris International's application in January 2018.[113] The advisory panel made recommendations about the
application to the FDA in January 2018,[113] though the review for these applications is still ongoing.[114] In March 2017, Philip Morris International submitted to the US FDA for a
premarket tobacco product application regarding its IQOS product.[115] In December 2017, Reuters published documents and testimonies of former employees detailing
irregularities in the clinical trials conducted by Philip Morris International for the approval of the IQOS product by the US FDA.[116] The FDA announced permission for the sale of
IQOS in the US on April 30, 2019.[117] This permission also requires the company to follow strict marketing restrictions.[117]

iSmoke OneHitter
iSmoke OneHitter by iSmoke can be used as a loose-leaf tobacco vaporizer or for use with waxy oils.[118] It is described as a "heat, not burn" tobacco vaporizer.[119] It was launched in
2015.[120] It has a chamber that can be filled with up to 800-milligrams of tobacco.[118]

IUOC 2
IUOC 2 is marketed by Shenzhen Yukan Technology Co., Limited from China.[121] The heat-not-burn device can be used with any brand of cigarettes.[121] A user inserts the entire
cigarette into the device.[121] It does not use a tobacco-filled cartridge.[121] IUOC 2.0 can use a regular pack of 20 cigarettes on a single battery charge.[121] IUOC is an acronym for "I
Use Ordinary Cigarette."[121] An updated version over the original IUOC, it was formally launched in 2018 at InterTabac in Germany.[121]

lil
The lil is a heat-not-burn cigarette product.[122] It heats a cigarette stick with a circular blade.[122] According to the company, a two-hour battery charge will last for up to 20 cigarette
sticks.[122] Its refills are cheaper than those of the IQOS and glo, and will fit in the IQOS product, although the manufacturer does not recommend this for safety reasons.[122] The lil
was formally launched by Korea Tobacco & Ginseng Corporation on November 20, 2017.[123]

Mok
China Tobacco debuted the Mok heat-not-burn device in Korea in May 2019.[124] According to the company, Mok is more compact and weighs less than other products such as glo,
IQOS, and lil.[124] The Coo sticks are longer and wider than tobacco sticks from other companies.[124]

Pax vaporizers
In 2010 Ploom launched a butane-powered product used for the heating tobacco or botanical products.[125] Later models replaced butane heating with an electric system.[126] After its
initial partnership with Japan Tobacco was abandoned, the company became known as Pax Labs.[127]

PAX vaporizers[128] referred to as heat-not-burn vaporizers,[129] are sold by Pax Labs (formerly known as Ploom).[130] The Pax 2 uses loose plant material such as tobacco or cannabis.
[131]
The surface of the Pax 2 remains cool, while the oven heats to temperatures up to 455 °F.[132] It has four temperature options.[132] Pax Era uses cannabis concentrates.[36] Pax 3
can be used to heat cannabis flower.[133] It takes 15 seconds to heat up.[87]

Ploom vaporizers
In January 2016, Japan Tobacco released Ploom Tech.[134] Japan Tobacco's Ploom has been withdrawn from the US.[82] The Ploom brand, however, remained with Japan Tobacco
and the product itself has been replaced with a different product called Ploom Tech, in which an aerosol passes through a capsule of granulated tobacco leaves.[135] The Ploom brand
uses capsules called Vapodes.[16] The capsules are aluminum and the tobacco heats up to 180 °C.[16] The Ploom Tech product heats up more and thus may generate more harmful
emissions.[16] It is referred to as a heat-not-burn device.[136] In January 2019, they introduced Ploom TECH+ and Ploom S in Tokyo, Japan.[137]
Sales are being expanded throughout Japan in 2017.[138] They intend to spend $500 million to increase their heated tobacco manufacturing capacity by late 2018.[139] Studies have
not been conducted on Japan Tobacco International's Ploom product, as of 2017.[52]

Pulze
In 2018, it was reported that Imperial Brands was developing a heat-not-burn tobacco product named Pulze.[140] It is expected to launch in 2019 in Japan.[141]

TEEPS
In December 2017, Philip Morris International launched TEEPS in the Dominican Republic.[142] It is a heat-not-burn product that looks similar to a traditional cigarette.[142] Without
using an electrically controlled heating system, it uses a carbon heat source that, once lit, passes heat to a processed tobacco plug.[35]

V2 Pro products
V2 originally released their vaporizer line named V2 Pro in July 2014.[143] The initial product was named Series 3.[143] Pro Series 3 comes with a battery, USB changer, and 3
cartridges.[144] One for e-liquid, one for wax for concentrates and oils, and a loose-leaf cartridge, which heats the material by conduction.[144] The e-liquid is heated to the lowest
temperature, and the leaves to the highest.[144] Pro Series 3X also by V2 can be used with dry material.[145] It has three different air flow options that can be adjusted with a slight
turn of the mouthpiece.[145] Pro Series 7 comes with a USB power cable, wall adapter, an e-liquid cartridge, and a loose-leaf cartridge.[146] A cartridge for concentrates can be
purchased separately.[146] Pro Series 7 has an adjustable temperature setting that is activated by a button.[143]

Comparison to mainstream smoke of traditional cigarettes

Tab. 1

Contents of selected analytes in the mainstream aerosol of a heat-not-burn tobacco product compared to the mainstream smoke of traditional cigarettes.[9] The highest and
lowest values given by Mallock et al. in 2 different types of tobacco sticks and Counts et al. were found in traditional cigarettes.[9] Column 5 shows the reduction of the analytes in
the mainstream aerosol of the heat-not-burn tobacco product compared to traditional cigarettes in % shown.[9]

Tobacco sticks (Mallock et al. 2018; [15]) Traditional Cigarettes (Counts et al. 2005; [18]) Reduction

Parameter Unit Min.–Max. Min.–Max. %

Puff count puff/stick 12 5,5–13,6 –

TPM mg/stick 51,2–52,6 27,5–60,9 –

Nicotine mg/stick 1,1 1,07–2,70 –

Water mg/stick 28,0–31,7 9,8–21,4 –

NFDPM mg/stick 19,8–21,6 16,3–37,6 –

Acetaldehyde µg/stick 179,4–183,5 930–1540 80,5–88,2

Acrolein µg/stick 8,9–9,9 89,2–154,1 89,5–93,9

Formaldehyde µg/stick 4,7–5,3 29,3–130,3 82,9–96,2

Crotonaldehyde µg/stick <3,0 32,7–70,8 –

1,3-Butadiene µg/stick 0,20–0,2 77,0–116,7 99,7–99,8

Benzine µg/stick 0,5–0,6 49,7–98,3 98,8–99,4

Isoprene µg/stick 1,8–2,1 509–1160 99,6–99,8

Styrene µg/stick 0,5 15,4–33,3 96,9–98,6

Toluene µg/stick 2,0–2,2 86,2–176,2 97,6–98,8

Tobacco stick, d. h. for heat-not-burn tobacco products: a tobacco stick; for traditional cigarette: a cigarette[9]
All values were generated using the Health Canada Intense (HCI) puffing conditions[9]
TPM total particulate matter, NFDPM nicotine-free dried particulate matter[9]

Prevalence
Heat-not-burn tobacco products are being introduced in markets around the world, as of 2017.[147] Since mid-2017, heat-not-burn tobacco products were sold in 27 countries.[148] As
of 2017, the market for such products is anticipated to expand by 60% over the next 10 to 15 years.[30] They are globally not as popular as the e-cigarette.[31] As of 2018, the IQOS is
the most popular product.[31] The IQOS is allowed to be sold in the US, as of April 30, 2019.[117]

As of April 2018, the industry was rapidly introducing new heat-not-burn tobacco products.[41] As of January 2018, British American Tobacco's iFuse is available in Romania, Japan,
Switzerland, Canada, South Korea, and Russia.[41] As of January 2018, Japan Tobacco International's Ploom TECH's is available in Japan and Switzerland.[41] As of January 2018,
KT&G Corp.'s lil is available in South Korea.[41] As of January 2018, Philip Morris International's IQOS is available in Canada, Guatemala, Colombia, Czech Republic, Denmark,
France, Germany, Greece, Israel, Italy, Kazakhstan, Lithuania, Monaco, Netherlands, Poland, Portugal, Romania, Russia, Serbia, Slovak Republic, Slovenia, Spain, Switzerland,
Ukraine, UK, South Africa, South Korea, Japan, and New Zealand.[41] Heat-not-burn tobacco products were first sold in Japan.[149] Several heat-not-burn tobacco brands are
marketed in Japan since 2014.[147] Japan is the largest market for heat-not-burn tobacco products.[150] As of early 2018, these products are not sold in France.[16]

Tobacco industry leaders have predicted heat-not-burn tobacco products are poised to further displace traditional cigarette smoking and, by extension, tobacco control strategies
typically framed around cigarettes.[147] Yet, little is known about the popularity of these products.[147]

Heat-not-burn (heated tobacco) searches originating in Japan have experienced tremendous growth.[147] Since the introduction of Philip Morris International's IQOS brand in select
Japanese cities in November 2014, searches for heat-not-burn (heated tobacco) products have increased substantially.[147] Average monthly searches rose 1,426% (95%CI: 746
–3,574) between the first (2015) and second (2016) complete years heat-not-burn tobacco (heated tobacco) was marketed.[147] Queries for heat-not-burn (heated tobacco) products
continued to grow an additional 100% (95%CI: 60–173) between the products second (2016) and third years on the market (Jan-Sep 2017).[147] In practical terms, there are now
between 5.9 and 7.5 million heat-not-burn (heated tobacco) related Google searches in Japan each month based on the latest search estimates for September 2017.[147] Moreover,
forecasts relying on the historical trend suggest heat-not-burn (heated tobacco) searches will increase an additional 32% (95%CI: -4 to 79) during 2018, compared to current
estimates for 2017 (January-September), with further growth expected.[147]
Queries for heat-not-burn (heated tobacco) in Japan occur more frequently than queries for e-cigarettes in the United States, with the Japanese heat-not-burn queries first eclipsing
e-cigarette queries in April 2016.[147] Further, the change in average monthly queries for heat-not-burn (heated tobacco) in Japan between 2015 and 2017 was 399 (95% CI: 184
–1,490) times larger than the change in average monthly queries for e-cigarettes in the Unites States over the same time period, increasing by 2,956% (95%CI: 1,729–7,304)
compared to only 7% (95%CI: 3–13).[147] These results indicate that interest in heat-not-burn (heated tobacco) may outpace interest in e-cigarettes (in areas where they are
introduced) not just now but for years to come.[147]

Google searches for heat-not-burn tobacco (heated tobacco) outpace


past rise of electronic cigarettes.[147] The above figure shows the
Relative Search Volume (scaled from 0–100 and adjusted for number of
total Google search volumes per month in Japan and the USA) for heat-
not-burn (heated tobacco) and e-cigarette products.[147]

Demand for heat-not-burn tobacco products presents a host of tobacco control challenges similar to e-cigarettes and new challenges specific to these products.[147] Heat-not-burn
tobacco products have been advertised as reduced-risk tobacco products in their Japanese test market, and these marketing messages will undoubtedly contaminate other markets
even where such messaging is banned.[147] Tobacco control advocates will have to develop strategies to both discover and then disseminate messages about the health risks
associated with these products.[147] Further, tobacco control advocates will have to consider making adjustments to existing tobacco control policies so that they apply to heat-not-
burn tobacco products.[147] For example, policy makers want to extend existing indoor smoking bans to include the emissions from heat-not-burn tobacco products, whether to
stigmatize their use or protect bystanders from potentially hazardous emissions.[147]

Marketing
The term "heat-not-burn" refers to tobacco heated (at ~350 °C) by an electrically-powered element or carbon, not combusted (at
~800 °C).[31] Terms used in marketing of cigarette-like products that "heat rather than burn" are referring to the product as "reduced
risk" and "innovative."[15] Marketing slogans like "heat-not-burn" cannot be a substitute for science.[105] The tobacco industry has called
them "heat-not-burn" products, although it has backtracked from this claim, as of 2018.[16] Heat-not-burn tobacco products are not
typically marketed as a harmless substitute to smoking.[47] The IQOS product has been advertised as emitting "no smoke."[151] These
products are marketed as a "smoke-free" alternative to traditional cigarettes, and promoted as a way to lower risk from smoking.[27] It is
expected that the promotion associated with these products will worsen the worldwide tobacco risk.[16]

Companies are using similar strategies previously used for traditional cigarettes.[152] They are marketed through a variety of outlets.[152]
This includes celebrities endorsing them.[152] "The tobacco industry has opened heat-not-burn product flagship stores, cafes and Temporary smoking room and a
sales promotion of glo at the 2016
sponsored public events such as concerts and car races around the world, which is alarming," said Judith Mackay, director of the Asian
Sendai Pageant of Starlight in
Consultancy on Tobacco Control.[152]
Kōtōdai-kōen Park.
Internal documents and statements by Philip Morris International researchers have contradicted Philip Morris International's claims
about reduced harm in regard to the IQOS product.[19] For example, in 2018, four Philip Morris International researchers who no longer
work for the company stated that the lowered levels of certain substances produced by the IQOS product does not automatically translated into the product being safer, but Philip
Morris International states the IQOS is safer than traditional cigarettes in part as a result of levels of 58 substances were lower in the IQOS aerosol than found in cigarette smoke.[19]

Philip Morris International has been intensively promoting its IQOS product in Europe and Asia, as of 2017.[109] Outside of an IQOS retail shop in Canada, marketing included a
display sign with the message, 'Building a Smoke-Free Future'.[153] Philip Morris International intends to convert its customers in Japan to using heat-not-burn products.[154] The
IQOS products are sold as an alternative to regular cigarettes.[155]

These products are marketed or anticipated to be marketed in nearly 40 countries, as of September 2017.[12] There has been significant controversy surrounding the marketing and
use of these products.[156] The tobacco companies are using a series of claims in the marketing of heat-not-burn tobacco products.[41] Both in websites and statements to the media
and investors, heat-not-burn tobacco products are presented as less harmful but not risk-free.[41] In a few instances, marketing materials claim that heat-not-burn tobacco products
are potentially helpful to smokers who want to quit.[41] Some media accounts of product launches state that heat-not-burn tobacco products reduce the levels of harmful tobacco
components by 90%–95% compared with traditional cigarettes, while others emphasise the lack of odor or visible emissions as part of marketing campaigns.[41] As of April 2018,
there is no evidence to confirm this claimed 90%–95% lower level of harm.[41] Other marketing claims highlight that these products produce no smoke, that is, are smoke-free.[41]
Implied in these claims, in advertisements and stores globally, is that smokers should switch from traditional cigarettes to these new, allegedly less harmful, products.[41] The
introduction of the latest generation of heat-not-burn tobacco products appears to be the latest chapter in the decades-old tobacco industry strategy of working to create
partnerships with governments and health advocates, presenting these alleged 'harm reduction' products as an option to address the tobacco epidemic.[41]

Product appeal and marketing terms used for online advertisement of heat-not-burn products.[15]

Product name Marketing terms Product appeal

IQOS Reduced risk product, innovative Clean (white, bright blue), stylish, elegant

Revo Reduced risk Similar sized package as traditional cigarette, white or light grey or gold

PAX 2 Smaller, smarter, sleeker Design, elegant and fun

iFuse Reduced risk Packed as traditional cigarette, stylish


The tobacco industry's use of the 'harm reduction' framework also serves to fracture the tobacco control movement, leaving it without a unified voice to communicate with the
public, the media and with policy makers on the strategies to advance tobacco control.[41] The concept of harm reduction has traditionally been embraced in several public health
fields such as clean needles for injectable drug use and has been explored by some tobacco control experts in the past, with enthusiasm for the possibility of harm reduction growing
with the widespread availability of e-cigarettes in certain markets.[41] The tobacco industry frames harm reduction as a common ground with health advocates and a possible entry
point to influence legislation and regulation of tobacco products.[41]

The tobacco companies use heat-not-burn tobacco products as part of their broader political and public relations activities to position them as 'partners' to address the tobacco
epidemic rather than as the vectors that are causing it.[41] This is a similar strategy previously used by the tobacco industry to promote itself as a partner of public health in reducing
the harms of tobacco, while obfuscating the scientific evidence pointing that harm reduction is achieved through tobacco control policies that decrease consumption.[41]

Regulation
Current smoking bans may not have been extended to include such products.[43] In the majority of the countries in which they have been sold, heat-not-burn tobacco products have
been taxed at a lower rate than traditional cigarettes.[157] Tobacco companies have used these products to seek exemptions and relaxations of existing tobacco control policies.[158]
Heat-not-burn tobacco products are used as an attempt by tobacco companies to influence regulatory policy to sustain and increase their clientele in the midst of decreasing
cigarette usage.[158]

In the United States, these products fall under the jurisdiction of the Food and Drug Administration as amended by the Family Smoking Prevention and Tobacco Control Act of
2016.[28] "There is concern that heat-not-burn tobacco will skirt local ordinances that prevent smoking in public areas," Mitchell H. Katz, director of the Los Angeles County Health
Agency, wrote in 2017.[43] Action on Smoking and Health stated in 2016 that "unless and until independent evidence shows that IQOS and similar products are substantially less
harmful than smoking then these products should be regulated in the same way as other tobacco products."[48] Tobacco control activist Stanton Glantz stated that the US FDA
should halt new tobacco products until tobacco companies stop selling traditional cigarettes.[159] It is recommended that indoor-smoking bans for traditional cigarettes be extended
to heat-not-burn tobacco products.[105] It is recommended that marketing of these products, and claims being made about them, should be regulated.[41]

Advertisement for the IQOS product itself is not regulated under the European Union Tobacco Products Directive.[82] Advertising for IQOS' tobacco stick may fall under the
European Union Tobacco Products Directive.[82] The UK government has been looking into creating a separate category for taxing heat-not-burn tobacco products.[63]

Due to the alleged belief in heat-not-burn tobacco harm reduction in Italy, these products are exempted from the fiscal regimes of tobacco products.[58] Heat-not-burn tobacco
products enjoy the same tax reduction as e-cigarettes, which is half that of traditional cigarettes.[58] Moreover, the enforcement of various tobacco control regulations is only
minimally adopted for heated tobacco products in Italy.[58] First of all, health warnings are required to cover only 30% of the heat-not-burn tobacco product packaging (instead of
65% for traditional cigarettes), without pictorial images.[58] Second, comprehensive smoke-free regulations prohibiting smoking in all public places and workplaces do not apply to
heat-not-burn tobacco products.[58] Finally, advertising and promotions are not banned for these new products.[58] This is evident by the presence in several strategic Italian cities of
the "IQOS embassy" and "IQOS boutique", which are fancy concept stores where IQOS is promoted as a status symbol and people can try it for free.[58] Therefore, the most
recognized tobacco control policies (i.e., price/tax increase, smoking bans, advertising bans, and health warnings) have been compromised for heat-not-burn tobacco products in
Italy.[58]

Heat-not-burn tobacco products are not restricted for sale in Israel by the Ministry of Health.[160] Justice Ministry in Israel agreed with the view of three voluntary organizations that
the IQOS is a tobacco product, and the product should be regulated in the same manner as tobacco products.[161] In Israel IQOS are now taxed at the same rate as traditional
cigarettes.[162]

Ploom, IQOS, and glo fall under the Tobacco Business Act as tobacco products in Japan because they consist of tobacco leaf.[54] Ploom and IQOS are governed by the Tobacco
Industries Act regulations as tobacco products in Japan.[56] The Liberal Democratic Party will deliberate over increasing the tax rate for heat-not-burn tobacco products in April
2018.[163]

Electronic tobacco products using dry material are regulated as e-cigarettes in South Korea by the Ministry of Health and Welfare.[164] Korea regulates e-cigarettes differently than
traditional cigarettes for tax reasons.[165] As a result, IQOS are taxed at a decreased rate, compared to the 75% incurred on normal cigarettes.[165] Emerging tobacco products are
banned in Singapore by the Ministry of Health.[166] China plans to pass legislation to ban the sale of these products to minors, as of 2019.[167]

After IQOS launched a marketing campaign in New Zealand in December 2016, the Ministry of Health stated in 2017 that the refill sticks are not legal for sale in New Zealand under
the Smoke-free Environments Act 1990.[168] A representative for the company in New Zealand stated that IQOS product complies with the Smoke-Free Environments Act.[169] Three
meetings between Ministry of Health officials and people from the tobacco industry were held from May 30, 2017 through June 2, 2017 to "discuss regulation of new tobacco and
nicotine-delivery products".[170] Later on, in August 2017, the government stated they would initiate a review process before products are sold for heat-not-burn tobacco products
such as IQOS.[170] In 2018, Philip Morris International and the Ministry of Health were in a court over the legality of selling IQOS in New Zealand.[171] A New Zealand court decided
in March 2018 that the HEETs sticks used in the IQOS product are legal to sell in New Zealand.[172] Individuals can import heat-not-burn tobacco products to New Zealand for
personal use.[173] As of 2016, 19 countries have permitted the sale of IQOS.[105]

Notes
1. A heat-not-burn product,[1] is also variously known as heat-not-burn tobacco product (HNB),[2] heat-not-burn cigarette (HC),[3] heat-not-burn cig[4] HNB tobacco
product,[2] HnB tobacco product,[5] HNB product,[6] HnB product,[5] heat-not-burn tobacco device,[7] heat-not-burn system,[8] HnB system,[5] heat-not-burn (HNB)
device,[6] heat-not-burn device,[8] HNB device,[6] HnB tobacco device,[9] HnB device,[10] HNB cigarette,[11] heated tobacco product (HTB),[12] heated cigarette,[13] HTP
cigarette,[14] cigarette-like product,[15] mini-cigarette,[16] electronic heated tobacco product,[17] electronically-heated cigarette smoking system (EHCSS),[18] electrically
heated cigarette smoking system,[19] electrically heated tobacco system,[20] non-combusted cigarette,[21] non-combusted tobacco product,[21] tobacco heating
cigarette,[22] tobacco heating product,[22] tobacco heating system,[23] THS,[24] smokeless cigarette,[25] smokeless tobacco stick,[26] tobacco stick product,[27] loose-leaf
tobacco vaporizer,[28] LLTV,[28] tobacco vaporizer,[29] or a T-vapor.[30]

Bibliography
◾ McNeill, A; Brose, LS; Calder, R; Bauld, L; Robson, D (February 2018). "Evidence review of e-cigarettes and heated tobacco products 2018"
(https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/684963/Evidence_review_of_e-cigarettes_and_heated_tobacco_products_2018.pdf) (PDF). UK:
Public Health England. pp. 1–243.
◾ "Regulatory Impact Statement: Regulation of smokeless tobacco and nicotine-delivery products" (https://www.health.govt.nz/system/files/documents/pages/ris-regulation-
smokeless-tobacco-and-nicotine-delivery-products.pdf) (PDF). Ministry of Health (New Zealand). 2017. pp. 1–52.
◾ "Further development of the partial guidelines for implementation of Articles 9 and 10 of the WHO FCTC" (http://www.who.int/fctc/cop/cop7/FCTC_COP_7_9_EN.pdf?
ua=1&ua=1) (PDF). World Health Organization. 12 July 2016. pp. 1–11.
◾ "Alternatieve tabaksproducten: harm reduction?" (http://www.rivm.nl/bibliotheek/rapporten/2016-0103.pdf) [Alternative tobacco products: harm reduction?] (PDF). Netherlands
National Institute for Public Health and the Environment. 2016. p. 1–66.

References
(2018). "Cytotoxic effects of heated tobacco products (HTP) on human bronchial
1. Leigh, Noel J; Tran, Phillip L; O’Connor, Richard J; Goniewicz, Maciej Lukasz
epithelial cells" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252481). Tobacco 13. Craver, Richard (2 August 2015). "Reynolds' decision to stop marketing of heated
Control. 27 (Suppl 1): s26–s29. doi:10.1136/tobaccocontrol-2018-054317 cigarette Revo illustrates challenges in selling adult smokers on new products"
(https://doi.org/10.1136%2Ftobaccocontrol-2018-054317). ISSN 0964-4563 (https://www.journalnow.com/business/reynolds-decision-to-stop-marketing-of-
(https://www.worldcat.org/issn/0964-4563). PMC 6252481 heated-cigarette-revo-illustrates/article_afc1a516-29dc-55a5-8a54-
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252481). PMID 30185530 75bd32cddd60.html). Winston-Salem Journal.
(https://www.ncbi.nlm.nih.gov/pubmed/30185530). 14. Jeong, Won Tae; Cho, Hyun Ki; Lee, Hyung Ryeol; Song, Ki Hoon; Lim, Heung Bin
2. Jenssen, Brian P.; Walley, Susan C.; McGrath-Morrow, Sharon A. (2017). "Heat- (2019). "Comparison of the content of tobacco alkaloids and tobacco-specific
not-Burn Tobacco Products: Tobacco Industry Claims No Substitute for Science". nitrosamines in 'heat-not-burn' tobacco products before and after aerosol
Pediatrics. 141 (1): e20172383. doi:10.1542/peds.2017-2383 generation". Inhalation Toxicology. 30 (13–14): 527–533.
(https://doi.org/10.1542%2Fpeds.2017-2383). ISSN 0031-4005 doi:10.1080/08958378.2019.1572840
(https://www.worldcat.org/issn/0031-4005). PMID 29233936 (https://doi.org/10.1080%2F08958378.2019.1572840). ISSN 0895-8378
(https://www.ncbi.nlm.nih.gov/pubmed/29233936). (https://www.worldcat.org/issn/0895-8378). PMID 30741569
3. Kamada, Takahiro; Yamashita, Yosuke; Tomioka, Hiromi (2016). "Acute (https://www.ncbi.nlm.nih.gov/pubmed/30741569).
eosinophilic pneumonia following heat-not-burn cigarette smoking" 15. Staal, Yvonne CM; van de Nobelen, Suzanne; Havermans, Anne; Talhout, Reinskje
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167280). Respirology Case (2018). "New Tobacco and Tobacco-Related Products: Early Detection of Product
Reports. 4 (6): e00190. doi:10.1002/rcr2.190 (https://doi.org/10.1002%2Frcr2.190). Development, Marketing Strategies, and Consumer Interest"
ISSN 2051-3380 (https://www.worldcat.org/issn/2051-3380). PMC 5167280 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996176). JMIR Public Health and
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167280). PMID 28031826 Surveillance. 4 (2): e55. doi:10.2196/publichealth.7359
(https://www.ncbi.nlm.nih.gov/pubmed/28031826). (https://doi.org/10.2196%2Fpublichealth.7359). ISSN 2369-2960
4. Meg Neal (2 January 2015). "What Is a Heat-Not-Burn Cigarette and Can It Help (https://www.worldcat.org/issn/2369-2960). PMC 5996176
You Quit?" (https://gizmodo.com/what-is-a-heat-not-burn-cigarette-and-can-it-help- (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996176). PMID 29807884
you-q-1676879928). Gizmodo. (https://www.ncbi.nlm.nih.gov/pubmed/29807884). This article
5. Simonavicius, Erikas; McNeill, Ann; Shahab, Lion; Brose, Leonie S (2018). "Heat- incorporates text (http://publichealth.jmir.org/2018/2/e55/) by Yvonne CM Staal,
not-burn tobacco products: a systematic literature review". Tobacco Control: Suzanne van de Nobelen, Anne Havermans, and Reinskje Talhout available under
tobaccocontrol–2018–054419. doi:10.1136/tobaccocontrol-2018-054419 the CC BY 4.0 license.
(https://doi.org/10.1136%2Ftobaccocontrol-2018-054419). ISSN 0964-4563 16. Dautzenberg, B.; Dautzenberg, M.-D. (2018). "Le tabac chauffé : revue
(https://www.worldcat.org/issn/0964-4563). PMID 30181382 systématique de la littérature" [Systematic analysis of the scientific literature on
(https://www.ncbi.nlm.nih.gov/pubmed/30181382). This article heated tobacco]. Revue des Maladies Respiratoires (in French). 36 (1): 82–103.
incorporates text doi:10.1016/j.rmr.2018.10.010 (https://doi.org/10.1016%2Fj.rmr.2018.10.010).
(https://tobaccocontrol.bmj.com/content/early/2019/01/28/tobaccocontrol-2018- ISSN 0761-8425 (https://www.worldcat.org/issn/0761-8425). PMID 30429092
054419) by Erikas Simonavicius, Ann McNeill1, Lion Shahab, and Leonie S Brose (https://www.ncbi.nlm.nih.gov/pubmed/30429092).
available under the CC BY 4.0 license. 17. St.Helen, Gideon; Jacob III, Peyton; Nardone, Natalie; Benowitz, Neal L (2018).
6. Mallock, Nadja; Böss, Lisa; Burk, Robert; Danziger, Martin; Welsch, Tanja; Hahn, "IQOS: examination of Philip Morris International's claim of reduced exposure"
Harald; Trieu, Hai-Linh; Hahn, Jürgen; Pieper, Elke; Henkler-Stephani, Frank; (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252487). Tobacco Control. 27
Hutzler, Christoph; Luch, Andreas (2018). "Levels of selected analytes in the (Suppl 1): s30–s36. doi:10.1136/tobaccocontrol-2018-054321
emissions of "heat not burn" tobacco products that are relevant to assess human (https://doi.org/10.1136%2Ftobaccocontrol-2018-054321). ISSN 0964-4563
health risks" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002459). Archives of (https://www.worldcat.org/issn/0964-4563). PMC 6252487
Toxicology. 92 (6): 2145–2149. doi:10.1007/s00204-018-2215-y (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252487). PMID 30158205
(https://doi.org/10.1007%2Fs00204-018-2215-y). ISSN 0340-5761 (https://www.ncbi.nlm.nih.gov/pubmed/30158205). This article
(https://www.worldcat.org/issn/0340-5761). PMC 6002459 incorporates text (https://tobaccocontrol.bmj.com/content/27/Suppl_1/s30.long) by
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002459). PMID 29730817 Gideon St.Helen, Peyton Jacob III, Natalie Nardone, and Neal L Benowitz available
(https://www.ncbi.nlm.nih.gov/pubmed/29730817). under the CC BY 4.0 license.
7. Paumgartten, Francisco J.R. (2018). "A critical appraisal of the harm reduction 18. Lindson-Hawley, Nicola; Hartmann-Boyce, Jamie; Fanshawe, Thomas R; Begh,
argument for heat-not-burn tobacco products" Rachna; Farley, Amanda; Lancaster, Tim (2016). "Interventions to reduce harm
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386018). Revista Panamericana from continued tobacco use"
de Salud Pública. 42: e161. doi:10.26633/RPSP.2018.161 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463938). Cochrane Database of
(https://doi.org/10.26633%2FRPSP.2018.161). ISSN 1020-4989 Systematic Reviews. 10: CD005231. doi:10.1002/14651858.CD005231.pub3
(https://www.worldcat.org/issn/1020-4989). PMC 6386018 (https://doi.org/10.1002%2F14651858.CD005231.pub3). ISSN 1465-1858
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386018). PMID 31093189 (https://www.worldcat.org/issn/1465-1858). PMC 6463938
(https://www.ncbi.nlm.nih.gov/pubmed/31093189). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463938). PMID 27734465
8. Kaur, Gurjot; Muthumalage, Thivanka; Rahman, Irfan (2018). "Mechanisms of (https://www.ncbi.nlm.nih.gov/pubmed/27734465).
toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging 19. Elias, Jesse; Dutra, Lauren M; St. Helen, Gideon; Ling, Pamela M (2018).
tobacco and non-tobacco products" "Revolution or redux? Assessing IQOS through a precursor product"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549714). Toxicology Letters. 288: (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238084). Tobacco Control. 27
143–155. doi:10.1016/j.toxlet.2018.02.025 (Suppl 1): s102–s110. doi:10.1136/tobaccocontrol-2018-054327
(https://doi.org/10.1016%2Fj.toxlet.2018.02.025). ISSN 0378-4274 (https://doi.org/10.1136%2Ftobaccocontrol-2018-054327). ISSN 0964-4563
(https://www.worldcat.org/issn/0378-4274). PMC 6549714 (https://www.worldcat.org/issn/0964-4563). PMC 6238084
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549714). PMID 29481849 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238084). PMID 30305324
(https://www.ncbi.nlm.nih.gov/pubmed/29481849). (https://www.ncbi.nlm.nih.gov/pubmed/30305324).
9. Pieper, Elke; Mallock, Nadja; Henkler-Stephani, Frank; Luch, Andreas (2018). 20. Pacitto, A.; Stabile, L.; Scungio, M.; Rizza, V.; Buonanno, G. (2018).
"Tabakerhitzer als neues Produkt der Tabakindustrie: Gesundheitliche Risiken" "Characterization of airborne particles emitted by an electrically heated tobacco
["Heat not burn" tobacco devices as new tobacco industry products: health risks]. smoking system". Environmental Pollution. 240: 248–254.
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz (in German). doi:10.1016/j.envpol.2018.04.137 (https://doi.org/10.1016%2Fj.envpol.2018.04.137).
61 (11): 1422–1428. doi:10.1007/s00103-018-2823-y ISSN 0269-7491 (https://www.worldcat.org/issn/0269-7491). PMID 29747109
(https://doi.org/10.1007%2Fs00103-018-2823-y). ISSN 1436-9990 (https://www.ncbi.nlm.nih.gov/pubmed/29747109).
(https://www.worldcat.org/issn/1436-9990). PMID 30284624 21. "How are Non-Combusted Cigarettes, Sometimes Called Heat-Not-Burn Products,
(https://www.ncbi.nlm.nih.gov/pubmed/30284624). This article Different from E-Cigarettes and Cigarettes?" (https://www.fda.gov/tobacco-
incorporates text (https://link.springer.com/article/10.1007%2Fs00103-018-2823-y) products/ctp-newsroom/how-are-non-combusted-cigarettes-sometimes-called-heat-
by Elke Pieper, Nadja Mallock, Frank Henkler-Stephani, and Andreas Luch available not-burn-products-different-e-cigarettes-and). United States Food and Drug
under the CC BY 4.0 license. Administration. 16 May 2019.
10. Caruana, Diane (25 October 2017). "BAT to launch its HnB device in Russia" 22. RIVM 2016, p. 36.
(https://www.vapingpost.com/2017/10/25/bat-to-launch-its-hnb-device-in-russia/). 23. McNeill 2018, p. 30.
VapingPost.
24. Kaunelienė, Violeta; Meišutovič-Akhtarieva, Marija; Martuzevičius, Dainius (2018).
11. Jenssen, Brian P.; Boykan, Rachel (2019). "Electronic Cigarettes and Youth in the "A review of the impacts of tobacco heating system on indoor air quality versus
United States: A Call to Action (at the Local, National and Global Levels)" conventional pollution sources". Chemosphere. 206: 568–578.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406299). Children. 6 (2): 30. Bibcode:2018Chmsp.206..568K
doi:10.3390/children6020030 (https://doi.org/10.3390%2Fchildren6020030). (http://adsabs.harvard.edu/abs/2018Chmsp.206..568K).
ISSN 2227-9067 (https://www.worldcat.org/issn/2227-9067). PMC 6406299 doi:10.1016/j.chemosphere.2018.05.039
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406299). PMID 30791645 (https://doi.org/10.1016%2Fj.chemosphere.2018.05.039). ISSN 0045-6535
(https://www.ncbi.nlm.nih.gov/pubmed/30791645). (https://www.worldcat.org/issn/0045-6535). PMID 29778082
12. "Heated tobacco products (HTPs) information sheet" (https://www.ncbi.nlm.nih.gov/pubmed/29778082).
(http://www.who.int/tobacco/publications/prod_regulation/heated-tobacco- 25. Haig, Matt (2003). Brand Failures: The Truth about the 100 Biggest Branding
products/en/). World Health Organization. May 2018. Mistakes of All Time (https://books.google.com/books?
id=6o7SrLdgx8gC&pg=PA51). Kogan Page Publishers. ISBN 978-0-7494-4433-4.
26. "Philip Morris' Smokeless Tobacco Stick Shouldn't Be Marketed As Safer Than 45. Górski, Paweł (2019). "E-cigarettes or heat-not-burn tobacco products —
Cigarettes, FDA Panel Says" (https://khn.org/morning-breakout/philip-morris- advantages or disadvantages for the lungs of smokers". Advances in Respiratory
smokeless-tobacco-stick-shouldnt-be-marketed-as-safer-than-cigarettes-fda-panel- Medicine. 87 (2): 123–134. doi:10.5603/ARM.2019.0020
says/). Kaiser Health News. 26 January 2018. (https://doi.org/10.5603%2FARM.2019.0020). ISSN 2543-6031
27. "Tobacco company charged over importing prohibited product" (https://www.worldcat.org/issn/2543-6031). PMID 31038725
(https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=11858402). The (https://www.ncbi.nlm.nih.gov/pubmed/31038725).
New Zealand Herald. 18 May 2017. 46. McNeill 2018, p. 219.
28. Lopez, Alexa A.; Hiler, Marzena; Maloney, Sarah; Eissenberg, Thomas; Breland, 47. Kotz, Daniel; Kastaun, Sabrina (2018). "E-Zigaretten und Tabakerhitzer:
Alison B. (2016). "Expanding clinical laboratory tobacco product evaluation methods repräsentative Daten zu Konsumverhalten und assoziierten Faktoren in der
to loose-leaf tobacco vaporizers" deutschen Bevölkerung (die DEBRA-Studie)" [E-cigarettes and heat-not-burn
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140724). Drug and Alcohol products: representative data on consumer behaviour and associated factors in the
Dependence. 169: 33–40. doi:10.1016/j.drugalcdep.2016.10.005 German population (the DEBRA study)]. Bundesgesundheitsblatt -
(https://doi.org/10.1016%2Fj.drugalcdep.2016.10.005). ISSN 0376-8716 Gesundheitsforschung - Gesundheitsschutz (in German). 61 (11): 1407–1414.
(https://www.worldcat.org/issn/0376-8716). PMC 5140724 doi:10.1007/s00103-018-2827-7 (https://doi.org/10.1007%2Fs00103-018-2827-7).
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140724). PMID 27768968 ISSN 1436-9990 (https://www.worldcat.org/issn/1436-9990). PMID 30284626
(https://www.ncbi.nlm.nih.gov/pubmed/27768968). (https://www.ncbi.nlm.nih.gov/pubmed/30284626).
29. Queloz, Sébastien; Etter, Jean-François (2019). "An online survey of users of 48. "ASH reaction to new Philip Morris IQOS 'heat not burn' product"
tobacco vaporizers, reasons and modes of utilization, perceived advantages and (http://ash.org.uk/media-and-news/press-releases-media-and-news/ash-reaction-to-
perceived risks" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537171). BMC new-philip-morris-iqos-heat-not-burn-product/). ASH UK. 30 November 2016.
Public Health. 19 (1): 642. doi:10.1186/s12889-019-6957-0 49. Katz, Mitchell H. (July 2017). "No Smoke—Just Cancer-Causing Chemicals". JAMA
(https://doi.org/10.1186%2Fs12889-019-6957-0). ISSN 1471-2458 Internal Medicine. 177 (7): 1052. doi:10.1001/jamainternmed.2017.1425
(https://www.worldcat.org/issn/1471-2458). PMC 6537171 (https://doi.org/10.1001%2Fjamainternmed.2017.1425). ISSN 2168-6106
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537171). PMID 31133009 (https://www.worldcat.org/issn/2168-6106). PMID 28531245
(https://www.ncbi.nlm.nih.gov/pubmed/31133009). This article (https://www.ncbi.nlm.nih.gov/pubmed/28531245).
incorporates text
50. McNeill 2018, p. 208.
(https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-6957-0) by
51. McNeill 2018, p. 210.
Sébastien Queloz and Jean-François Etter available under the CC BY 4.0 license.
30. Unger, Michael; Unger, Darian W. (2018). "E-cigarettes/electronic nicotine delivery 52. MHNZ 2017, p. 5.
systems: a word of caution on health and new product development" 53. "Statement on the toxicological evaluation of novel heat-not-burn tobacco product"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178300). Journal of Thoracic (https://cot.food.gov.uk/sites/default/files/heat_not_burn_tobacco_statement.pdf)
Disease. 10 (S22): S2588–S2592. doi:10.21037/jtd.2018.07.99 (PDF). Committee on Toxicity. 11 December 2017. pp. 1–10.
(https://doi.org/10.21037%2Fjtd.2018.07.99). ISSN 2072-1439 54. Tabuchi, Takahiro; Gallus, Silvano; Shinozaki, Tomohiro; Nakaya, Tomoki;
(https://www.worldcat.org/issn/2072-1439). PMC 6178300 Kunugita, Naoki; Colwell, Brian (2018). "Heat-not-burn tobacco product use in
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178300). PMID 30345095 Japan: its prevalence, predictors and perceived symptoms from exposure to
(https://www.ncbi.nlm.nih.gov/pubmed/30345095). secondhand heat-not-burn tobacco aerosol"
31. Li, Gerard; Saad, Sonia; Oliver, Brian; Chen, Hui (2018). "Heat or Burn? Impacts of (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073918). Tobacco Control. 27 (e1):
Intrauterine Tobacco Smoke and E-Cigarette Vapor Exposure on the Offspring's e25–e33. doi:10.1136/tobaccocontrol-2017-053947
Health Outcome" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160993). Toxics. (https://doi.org/10.1136%2Ftobaccocontrol-2017-053947). ISSN 0964-4563
6 (3): 43. doi:10.3390/toxics6030043 (https://doi.org/10.3390%2Ftoxics6030043). (https://www.worldcat.org/issn/0964-4563). PMC 6073918
ISSN 2305-6304 (https://www.worldcat.org/issn/2305-6304). PMC 6160993 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073918). PMID 29248896
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160993). PMID 30071638 (https://www.ncbi.nlm.nih.gov/pubmed/29248896).
(https://www.ncbi.nlm.nih.gov/pubmed/30071638). This article 55. Marynak, Kristy L.; Wang, Teresa W.; King, Brian A.; Agaku, Israel T.; Reimels,
incorporates text (https://www.mdpi.com/2305-6304/6/3/43/htm) by Gerard Li, Sonia Elizabeth A.; Graffunder, Corinne M. (2018). "Awareness and Ever Use of "Heat-
Saad, Brian G. Oliver, and Hui Chen available under the CC BY 4.0 license. Not-Burn" Tobacco Products Among U.S. Adults, 2017". American Journal of
32. Caputi, TL (24 August 2016). "Industry watch: heat-not-burn tobacco products are Preventive Medicine. 55 (4): 551–554. doi:10.1016/j.amepre.2018.04.031
about to reach their boiling point". Tobacco Control. 26 (5): 609–610. (https://doi.org/10.1016%2Fj.amepre.2018.04.031). ISSN 0749-3797
doi:10.1136/tobaccocontrol-2016-053264 (https://www.worldcat.org/issn/0749-3797). PMID 30033025
(https://doi.org/10.1136%2Ftobaccocontrol-2016-053264). PMID 27558827 (https://www.ncbi.nlm.nih.gov/pubmed/30033025).
(https://www.ncbi.nlm.nih.gov/pubmed/27558827). 56. Tabuchi, Takahiro; Kiyohara, Kosuke; Hoshino, Takahiro; Bekki, Kanae; Inaba,
33. Bentley, Guy (15 March 2017). "Heat-Not-Burn Tobacco: The Next Wave Of A Yohei; Kunugita, Naoki (2016). "Awareness and use of electronic cigarettes and
Harm-Reduction Revolution" heat-not-burn tobacco products in Japan". Addiction. 111 (4): 706–713.
(https://www.forbes.com/sites/realspin/2017/03/15/heat-not-burn-tobacco-the-next- doi:10.1111/add.13231 (https://doi.org/10.1111%2Fadd.13231). ISSN 0965-2140
wave-of-a-harm-reduction-revolution/#629237cc6292). Forbes. (https://www.worldcat.org/issn/0965-2140). PMID 26566956
(https://www.ncbi.nlm.nih.gov/pubmed/26566956).
34. MHNZ 2017, p. 4.
35. Stefanie Rossel (1 June 2017). "The heat is on" 57. Mulier, Thomas; Chambers, Sam; Liefgreen, Liefgreen (24 March 2016). "Marlboro
(https://www.tobaccoreporter.com/2017/06/the-heat-is-on/). Tobacco Reporter. Kicks Some Ash" (https://www.bloomberg.com/news/articles/2016-03-24/marlboro-
kicks-some-ash). Bloomberg News.
36. Marinova, Polina (22 April 2019). "Vaping Startup Pax Labs Raises $420 Million in
58. Liu, Xiaoqiu; Lugo, Alessandra; Spizzichino, Lorenzo; Tabuchi, Takahiro; Gorini,
Funding: Term Sheet for Monday, April 22" (http://fortune.com/2019/04/22/term-
Giuseppe; Gallus, Silvano (2018). "Heat-Not-Burn Tobacco Products Are Getting
sheet-monday-april-22/). Fortune.
Hot in Italy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911679). Journal of
37. WHO 2016, p. 6.
Epidemiology. 28 (5): 274–275. doi:10.2188/jea.JE20180040
38. McNeill 2018, p. 220. (https://doi.org/10.2188%2Fjea.JE20180040). ISSN 0917-5040
39. "Toxicological evaluation of novel heat-not-burn tobacco products – non-technical (https://www.worldcat.org/issn/0917-5040). PMC 5911679
summary" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911679). PMID 29657258
(https://cot.food.gov.uk/sites/default/files/heat_not_burn_tobacco_summary.pdf) (https://www.ncbi.nlm.nih.gov/pubmed/29657258). This article
(PDF). Committee on Toxicity. 11 December 2017. pp. 1–4. incorporates text
40. McNeill 2018, p. 23. (https://www.jstage.jst.go.jp/article/jea/28/5/28_JE20180040/_pdf/-char/en) by
Xiaoqiu Liu, Alessandra Lugo, Lorenzo Spizzichino, Takahiro Tabuchi, Giuseppe
41. Bialous, Stella A; Glantz, Stanton A (2018). "Heated tobacco products: another
Gorini, and Silvano Gallus available under the CC BY 4.0 license.
tobacco industry global strategy to slow progress in tobacco control"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202178). Tobacco Control. 27 59. Ziedonis, Douglas; Das, Smita; Larkin, Celine (2017). "Tobacco use disorder and
(Suppl 1): s111–s117. doi:10.1136/tobaccocontrol-2018-054340 treatment: New challenges and opportunities"
(https://doi.org/10.1136%2Ftobaccocontrol-2018-054340). ISSN 0964-4563 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741110). Dialogues in Clinical
(https://www.worldcat.org/issn/0964-4563). PMC 6202178 Neuroscience. 19 (3): 271–80. PMC 5741110
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202178). PMID 30209207 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741110). PMID 29302224
(https://www.ncbi.nlm.nih.gov/pubmed/30209207). This article (https://www.ncbi.nlm.nih.gov/pubmed/29302224).
incorporates text (https://tobaccocontrol.bmj.com/content/27/Suppl_1/s111.long) by
Stella A Bialous and Stanton A Glantz available under the CC BY 4.0 license.
42. Chin, Neo Chai (2 March 2017). "Heated tobacco products just as bad as cigarettes:
Amy Khor" (http://www.todayonline.com/singapore/heated-tobacco-products-just-
bad-cigarettes). Today (Singapore newspaper). Mediacorp.
43. Rapaport, Lisa (26 May 2017). " 'Heat-not-burn' cigarettes still release cancer-
causing chemicals" (https://www.reuters.com/article/us-health-tobacco-heatnotburn-
idUSKBN18M2JB). Reuters.
44. RIVM 2016, p. 5.
60. England, Lucinda J.; Kim, Shin Y.; Tomar, Scott L; Ray, Cecily S; Gupta, Prakash 79. MacGuill, Shane (23 January 2014). "Has Philip Morris Learned from Heat-not-Burn
C.; Eissenberg, Thomas; Cnattingius, Sven; Bernert, John T.; Tita, Alan Thevenet Tobacco's Past?" (http://blog.euromonitor.com/2014/01/can-philip-morris-must-
N.; Winn, Deborah M.; Djordjevic, Mirjana V.; Lambe, Mats; Stamilio, David; learn-from-the-mistakes-of-heat-not-burn-tobaccos-past.html). Euromonitor
Chipato, Tsungai; Tolosa, Jorge E. (2010). "Non-cigarette tobacco use among International.
women and adverse pregnancy outcomes" 80. Adriaens, Karolien; Gucht, Dinska Van; Baeyens, Frank (2018). "IQOSTM vs.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881107). Acta Obstetricia et e-Cigarette vs. Tobacco Cigarette: A Direct Comparison of Short-Term Effects after
Gynecologica Scandinavica. 89 (4): 454–464. doi:10.3109/00016341003605719 Overnight-Abstinence" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313326).
(https://doi.org/10.3109%2F00016341003605719). ISSN 0001-6349 International Journal of Environmental Research and Public Health. 15 (12): 2902.
(https://www.worldcat.org/issn/0001-6349). PMC 5881107 doi:10.3390/ijerph15122902 (https://doi.org/10.3390%2Fijerph15122902).
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881107). PMID 20225987 ISSN 1660-4601 (https://www.worldcat.org/issn/1660-4601). PMC 6313326
(https://www.ncbi.nlm.nih.gov/pubmed/20225987). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313326). PMID 30567400
61. Forster, Mark; Liu, Chuan; Duke, Martin G; McAdam, Kevin G; Proctor, Christopher (https://www.ncbi.nlm.nih.gov/pubmed/30567400). This article
J (2015). "An experimental method to study emissions from heated tobacco incorporates text (https://www.mdpi.com/1660-4601/15/12/2902/htm) by Karolien
between 100-200°C" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418098). Adriaens, Dinska Van Gucht, and Frank Baeyens available under the CC BY 4.0
Chemistry Central Journal. 9 (1): 20. doi:10.1186/s13065-015-0096-1 license.
(https://doi.org/10.1186%2Fs13065-015-0096-1). ISSN 1752-153X 81. Davies, Rob; Monaghan, Angela (30 November 2016). "Philip Morris's vision of
(https://www.worldcat.org/issn/1752-153X). PMC 4418098 cigarette-free future met with scepticism"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418098). PMID 25941536 (https://www.theguardian.com/business/2016/nov/30/philip-morris-stop-selling-
(https://www.ncbi.nlm.nih.gov/pubmed/25941536). cigarettes-alternative-iqos). The Guardian.
62. Davis, Barbara; Williams, Monique; Talbot, Prue (20 February 2018). "iQOS: 82. Harlay, Jérôme (9 November 2016). "What you need to know about Heat-not-Burn
evidence of pyrolysis and release of a toxicant from plastic" (HNB) cigarettes" (http://www.vapingpost.com/2016/11/09/what-you-need-to-know-
(https://tobaccocontrol.bmj.com/content/early/2018/02/20/tobaccocontrol-2017- about-heat-not-burn-cigarettes-hnb/). VapingPost.
054104). Tobacco Control. 28 (1): tobaccocontrol–2017–054104.
83. Tuinstra, Taco (16 December 2014). "Certified organic e-liquids being launched by
doi:10.1136/tobaccocontrol-2017-054104
VTM" (http://www.tobaccoreporter.com/2014/12/certified-organic-e-liquids-being-
(https://doi.org/10.1136%2Ftobaccocontrol-2017-054104) (inactive 24 July 2019).
launched-by-vtm/). Tobacco Reporter.
ISSN 0964-4563 (https://www.worldcat.org/issn/0964-4563). PMID 29535257
(https://www.ncbi.nlm.nih.gov/pubmed/29535257). 84. O'Connell, Thomas (9 July 2013). "US8479747B2 - Method for preparing tobacco
extract for electronic smoking devices"
63. McNeill 2018, p. 201.
(http://www.google.com/patents/US8479747). Google Patents.
64. Mcgill, Douglas C (19 November 1988). " 'Smokeless' Cigarette's Hapless Start"
85. Abbey Lewis and Angel Abcede (11 January 2017). "Top 24 Tobacco Products for
(https://www.nytimes.com/1988/11/19/business/smokeless-cigarette-s-hapless-
2017" (https://www.cspdailynews.com/tobacco/top-24-tobacco-products-
start.html). The New York Times. ISSN 0362-4331
2017#page=6). CSP magazine.
(https://www.worldcat.org/issn/0362-4331).
86. speccomm (15 November 2017). "HNB in wider distribution"
65. Parker-Pope, Tara (10 February 2001). " "Safer" Cigarettes: A History"
(https://www.tobaccoreporter.com/2017/11/hnb-in-wider-distribution/). Tobacco
(https://www.pbs.org/wgbh/nova/body/safer-cigarettes-history.html). PBS.
Reporter.
66. Hilts, Philip J. (27 November 1994). "Little Smoke, Little Tar, but Full Dose of
87. Esquire Editors (11 May 2019). "10 Best Weed Vaporizers to Buy in 2019"
Nicotine" (https://www.nytimes.com/1994/11/27/us/little-smoke-little-tar-but-full-
(https://www.esquire.com/lifestyle/g20952097/best-weed-vaporizers-to-buy-now/).
dose-of-nicotine.html). The New York Times. ISSN 0362-4331
Esquire.
(https://www.worldcat.org/issn/0362-4331).
88. Price, Emily (27 May 2019). "The Firefly 2+ Might Be The Cannabis Vaporizer Of
67. O'Connell, Dominic (30 November 2016). "Philip Morris could stop making
Your Dreams" (https://www.forbes.com/sites/emilyprice/2019/05/27/the-firefly-2-
conventional cigarettes" (https://www.bbc.com/news/business-38152297). BBC
might-be-the-cannabis-vaporizer-of-your-dreams/#8d3ce0f7fd7c). Forbes.
News.
89. Crist, Ry (20 April 2019). "Weed tech heats up with a new smart vaporizer from
68. Anderson, S J; Ling, P M (2008). " "And they told two friends...and so on": RJ
Apple, Microsoft alums" (https://www.cnet.com/news/weed-tech-heats-up-with-a-
Reynolds' viral marketing of Eclipse and its potential to mislead the public"
new-smart-vaporizer-from-firefly/). CNET.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845302). Tobacco Control. 17 (4):
90. "BAT finds strong Japan demand for its Glo smokeless tobacco device"
222–229. doi:10.1136/tc.2007.024273 (https://doi.org/10.1136%2Ftc.2007.024273).
(http://www.japantimes.co.jp/news/2017/03/22/business/corporate-business/bat-
ISSN 0964-4563 (https://www.worldcat.org/issn/0964-4563). PMC 2845302
finds-strong-japan-demand-glo-smokeless-tobacco-device/). The Japan Times.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845302). PMID 18332064
Reuters. 22 March 2017.
(https://www.ncbi.nlm.nih.gov/pubmed/18332064).
69. Haig, Matt (2005). Brand Failures: The Truth about the 100 Biggest Branding 91. Caruana, Diane (25 September 2018). "BAT Launches Glo in Ukraine"
Mistakes of All Time (https://books.google.com/books? (https://www.vapingpost.com/2018/09/25/bat-launches-glo-in-ukraine/). VapingPost.
id=6o7SrLdgx8gC&pg=PA51). Kogan Page Publishers. pp. 51–. ISBN 978-0-7494- 92. Caplinger, Dan (31 May 2017). "Here's Why the Worst Might Be Yet to Come for
4433-4. Philip Morris International" (https://www.fool.com/investing/2017/05/31/heres-why-
the-worst-might-be-yet-to-come-for-phili.aspx). The Motley Fool.
70. Fisher, Daniel (29 May 2014). "Is This The Cigarette Of The Future, And Will The
FDA Let You Buy It?" (https://www.forbes.com/sites/danielfisher/2014/05/29/is-this- 93. "Innovation Drives BAT's $47 Billion Bid -- WSJ"
the-cigarette-of-the-future-and-will-the-fda-let-you-buy-it/#1c0f86987478). Forbes. (https://www.advfn.com/news_Innovation-Drives-BATs-47-Billion-Bid-
71. "New heat-not-burn brand from RAI" (http://www.tobaccojournal.com/New_heat-not- WSJ_72727933.html). ADVFN. 24 October 2016.
burn_brand_from_RAI.52768.0.html). Tobacco Journal International. 5 January 94. Duprey, Rich (17 November 2018). "s British American Tobacco a Buy?"
2015. (https://www.fool.com/investing/2018/11/17/is-british-american-tobacco-a-buy.aspx).
The Motley Fool.
72. Craver, Richard (28 July 2015). "Reynolds ends Revo test market in Wisconsin"
(http://www.journalnow.com/business/business_news/local/reynolds-ends-revo-test- 95. News Desk (24 October 2016). "World's second largest tobacco company tells
market-in-wisconsin/article_e23495d0-353e-11e5-98d3-cbaf921dc91c.html). people to quit smoking" (https://tribune.com.pk/story/1208385/worlds-second-
Winston-Salem Journal. largest-tobacco-company-tells-people-quit-smoking/). The Express Tribune.
73. "Reynolds launching heat-not-burn cigarette" 96. Felberbaum, Michael (26 June 2014). "Philip Morris Int'l to Sell Marlboro HeatSticks"
(https://www.cbsnews.com/news/reynolds-launching-heat-not-burn-cigarette/). CBS (http://www.salon.com/2014/06/26/philip_morris_intl_to_sell_marlboro_heatsticks/).
News. Associated Press. 14 November 2014. Salon (website). Associated Press.
74. Pollack, Juddan (27 October 1997). "Philip Morris tries smokeless Accord: tobacco 97. Caplinger, Dan (23 November 2015). "5 Things Every Philip Morris Investor Should
marketer, cautious about brand, doing 'consumer research' " Know" (https://www.fool.com/investing/general/2015/11/23/5-things-every-philip-
(http://adage.com/article/news/philip-morris-smokeless-accord-tobacco-marketer- morris-investor-should-know.aspx). The Motley Fool.
cautious-brand-consumer-research/70262/). Ad Age. 98. Nathan, Ralph (12 October 2016). "Why Philip Morris's iQOS Sales in Japan Are
75. "Anti-smoking body attacks smokeless cigarette device" Promising" (http://marketrealist.com/2016/10/philip-morris-iqos-sales-japan-
(http://www.tobaccojournal.com/Anti- promising/). Market Realist.
smoking_body_attacks_smokeless_cigarette_device.48750.0.html). Tobacco 99. Kary, Tiffany (17 April 2019). "Philip Morris Says It Doesn't Want You to Buy Its
Journal International. 11 December 2007. Cigarettes" (https://www.bloomberg.com/news/articles/2019-04-17/philip-morris-
76. Houston, Cameron (27 June 2007). "Revealed: tobacco giant's secret new weapon says-it-doesn-t-want-you-to-buy-its-cigarettes). Bloomberg News.
in the age of smoking bans" (http://www.theage.com.au/news/national/tobacco- 100. Mulier, Thomas; Thesing, Gabi (26 June 2014). "Philip Morris Sees $700 Million
giants-secret-new-weapon/2007/06/26/1182623909034.html). The Age. Boost From iQOS Smoking Device" (https://www.bloomberg.com/news/2014-06-
77. Cooper, Ted (1 February 2014). "Why Philip Morris International's New Heated 26/philip-morris-sees-700-million-boost-from-iqos-smoking-device.html). Bloomberg
Products Will Do Better Than Its Last Attempt" News.
(http://www.fool.com/investing/general/2014/02/01/why-philip-morris-internationals- 101. Uranaka, Taiga; Ando, Ritsuko (22 October 2018). "Philip Morris Aims to Revive
new-heated-produc.aspx). The Motley Fool. Japan Sales With Cheaper Heat-Not-Burn Tobacco"
78. Lubin, Gus (25 June 2012). "Philip Morris Is Releasing A Bunch Of Crazy New (https://money.usnews.com/investing/news/articles/2018-10-22/philip-morris-seeks-
Cigarettes" (http://www.businessinsider.fr/us/philip-morris-is-releasing-a-ton-of-cool- bigger-japan-share-with-cheaper-heat-not-burn-tobacco). U.S. News & World
new-cigarettes-2012-6/). Business Insider. Report.
102. LaVito, Angelica (22 October 2018). "Philip Morris unveils new smokeless cigarettes 122. Song Seung-hyun (7 November 2017). "KT&G launches e-cigarette brand to take
in a bid to rev up sales" (https://www.cnbc.com/2018/10/23/philip-morris-unveils- on foreign rivals" (http://www.theinvestor.co.kr/view.php?ud=20171107000791). The
new-versions-of-iqos-cigarettes-to-boost-sales.html). CNBC. Investor.
103. Hyo-sik, Lee (17 May 2017). "Philip Morris unveils smoke-free cigarette in Korea" 123. "KT&G launches sales of new tobacco-heating device"
(http://m.koreatimes.co.kr/phone/news/view.jsp?req_newsidx=229533). The Korea (http://english.yonhapnews.co.kr/business/2017/11/20/69/0501000000AEN20171120011300320F.html)
Times. Yonhap News Agency. 11 November 2017.
104. McKelvey, Karma; Popova, Lucy; Kim, Minji; Chaffee, Benjamin W; Vijayaraghavan, 124. "New HNB Device from China Tobacco" (https://www.tobaccoasia.com/product-
Maya; Ling, Pamela; Halpern-Felsher, Bonnie (November 2018). "Heated tobacco news/new-hnb-device-from-china-tobacco/). Tobacco Asia. 30 May 2019.
products likely appeal to adolescents and young adults" 125. Biggs, John (17 June 2012). "Smoke Up: An Interview With The Creator Of The
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252490). Tobacco Control. 27 Ultracool Pax Vaporizer" (https://techcrunch.com/2012/06/17/an-interview-with-the-
(Suppl 1): s41–s47. doi:10.1136/tobaccocontrol-2018-054596 creator-of-the-ultracool-pax-vaporizer/). TechCrunch.
(https://doi.org/10.1136%2Ftobaccocontrol-2018-054596). ISSN 0964-4563
126. Lavrinc, Damon (1 July 2013). "Review: Ploom Model Two"
(https://www.worldcat.org/issn/0964-4563). PMC 6252490
(https://www.wired.com/2013/07/ploom-two/). Wired.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252490). PMID 30352843
(https://www.ncbi.nlm.nih.gov/pubmed/30352843). 127. Lawler, Ryan (11 March 2015). "The Pax 2 Improves Upon One Of The Best
Vaporizers On The Market" (https://techcrunch.com/2015/03/11/this-was-published-
105. Auer, Reto; Concha-Lozano, Nicolas; Jacot-Sadowski, Isabelle; Cornuz, Jacques;
at-4-20/). TechCrunch.
Berthet, Aurélie (1 July 2017). "Heat-Not-Burn Tobacco Cigarettes: Smoke by Any
128. Dawson, Freddie (31 July 2015). "Pax Labs Looking At International Expansion"
Other Name" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543320). JAMA
(https://www.forbes.com/sites/freddiedawson/2015/07/31/pax-labs-looking-at-
Internal Medicine. 177 (7): 1050–1052. doi:10.1001/jamainternmed.2017.1419
international-expansion/). Forbes.
(https://doi.org/10.1001%2Fjamainternmed.2017.1419). ISSN 2168-6106
(https://www.worldcat.org/issn/2168-6106). PMC 5543320 129. Page, Barnaby (17 February 2015). "Ploom and JTI agree to split up, divide heat-
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543320). PMID 28531246 not-burn brands" (https://ecigintelligence.com/ploom-and-jti-agree-to-split-up-divide-
(https://www.ncbi.nlm.nih.gov/pubmed/28531246). modeltwo-and-pax-brands/). ECigIntelligence.
106. Duprey, Rich (9 December 2017). "Will 2018 Be Philip Morris International Inc's 130. Yakowicz, Will (10 June 2015). "This Silicon Valley Company Just Raised $47
Best Year Yet?" (http://billingsgazette.com/business/investment/markets-and- Million to Smoke Cigarette Makers" (http://www.inc.com/will-yakowicz/pax-labs-
stocks/will-be-philip-morris-international-inc-s-best-year-yet/article_6c45c0ed-01bf- vaporizer-company-raises-47-million.html). Inc.
5b95-aa9f-d84e9b9a312b.html). Billings Gazette. 131. Adam Clark Estes (23 July 2015). "Pax 2 Vaporizer Review: It's Like Smoking In the
107. Rossel, Stefanie (1 June 2016). "All eyes on iQOS" Future" (https://gizmodo.com/pax-2-vaporizer-review-its-like-smoking-in-the-future-
(http://www.tobaccoreporter.com/2016/06/all-eyes-on-iqos/). Tobacco Reporter. 1718310779). Gizmodo.
108. Tai, Mariko (31 August 2015). "Philip Morris rolls out iQOS smokeless smokes" 132. Stenovec, Tim (12 March 2016). "How two guys from Stanford built the 'iPhone of
(http://asia.nikkei.com/Business/Trends/Philip-Morris-rolls-out-iQOS-smokeless- vaporizers' " (http://www.businessinsider.com/what-is-the-pax-vaporizer-2016-3).
smokes). Nikkei Asian Review. Business Insider.
109. Drope, Jeffrey; Cahn, Zachary; Kennedy, Rosemary; Liber, Alex C.; Stoklosa, 133. Taylor, Chris (19 June 2018). "Want to microdose marijuana? This company is
Michal; Henson, Rosemarie; Douglas, Clifford E.; Drope, Jacqui (2017). "Key issues making it easier for you" (https://mashable.com/2018/06/19/pax-era-marijuana-
surrounding the health impacts of electronic nicotine delivery systems (ENDS) and microdose/#v9BJiJTZbOqL). Mashable.
other sources of nicotine". CA: A Cancer Journal for Clinicians. 67 (6): 449–471. 134. Rossel, Stefanie (1 July 2016). "Blending nature and technology"
doi:10.3322/caac.21413 (https://doi.org/10.3322%2Fcaac.21413). ISSN 0007-9235 (http://www.tobaccoreporter.com/2016/07/blending-nature-and-technology/).
(https://www.worldcat.org/issn/0007-9235). PMID 28961314 Tobacco Reporter.
(https://www.ncbi.nlm.nih.gov/pubmed/28961314). 135. Tuinstra, Taco (26 January 2016). "JT announces launch of next-generation Ploom"
110. "Addictive nicotine and harmful substances also present in heated tobacco" (http://www.tobaccoreporter.com/2016/01/jt-announces-launch-of-next-generation-
(https://www.rivm.nl/en/Documents_and_publications/Common_and_Present/Newsmessages/2018/Addictive_nicotine_and_harmful_substances_also_present_in_heated_tobacco)
ploom/). Tobacco Reporter.
Netherlands National Institute for Public Health and the Environment. 15 May 2018. 136. speccomm (26 August 2016). "Japan taking to heat-not-burn"
111. Trefis Team (30 December 2016). "FDA Approval For iQOS To Be A Game (https://www.tobaccoreporter.com/2016/08/japan-taking-to-heat-not-burn/). Tobacco
Changer For Altria" (https://www.forbes.com/sites/greatspeculations/2016/12/30/fda- Reporter.
approval-for-iqos-to-be-a-game-changer-for-altria/). Forbes. 137. Uranaka, Taiga (16 January 2019). "Japan Tobacco ratchets up smokeless war with
112. Hendlin, Yogi Hale; Elias, Jesse; Ling, Pamela M. (2017). "The new products" (https://www.reuters.com/article/us-japan-tobacco-products/japan-
Pharmaceuticalization of the Tobacco Industry" tobacco-ratchets-up-smokeless-war-with-new-products-idUSKCN1PB090). Reuters.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568794). Annals of Internal 138. "JT to expand Ploom TECH sales" (http://www.tobaccoreporter.com/2016/10/jt-to-
Medicine. 167 (4): 278–280. doi:10.7326/M17-0759 expand-ploom-tech-sales/). Tobacco Reporter. 10 October 2016.
(https://doi.org/10.7326%2FM17-0759). ISSN 0003-4819
139. Uranaka, Taiga; Sarkar, Himani (29 May 2017). "Japan Tobacco plans to quadruple
(https://www.worldcat.org/issn/0003-4819). PMC 5568794
smokeless tobacco output capacity by 2018: CEO"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568794). PMID 28715843
(http://www.channelnewsasia.com/news/business/japan-tobacco-plans-to-
(https://www.ncbi.nlm.nih.gov/pubmed/28715843).
quadruple-smokeless-tobacco-output-capacity-by-2018--ceo-8892958). Channel
113. "FDA Panel Gives Qualified Support To Claims For" NewsAsia. Reuters.
(https://www.npr.org/sections/health-shots/2018/01/25/580213742/fda-panel-gives-
140. "Imperial Brands aims to convince smokers to switch to vaping products"
qualified-support-to-claims-for-safer-smoking-device). National Public Radio. 25
(https://uk.news.yahoo.com/imperial-brands-aims-convince-smokers-
January 2018.
173000453.html?guccounter=1). Sky News. Yahoo! News. 6 November 2018.
114. Kaplan, Sheila; Thomas, Katie (11 February 2018). "F.D.A. Chief Goes Against the
141. Mulier, Thomas (27 September 2018). "Tobacco giant eyes cannabis 'wellness'
Administration Stereotype" (https://www.nytimes.com/2018/02/11/health/gottlieb-
move" (https://www.independent.ie/business/world/tobacco-giant-eyes-cannabis-
fda-drugs.html). The New York Times.
wellness-move-37358039.html). Irish Independent.
115. Caplinger, Dan (26 May 2017). "The FDA Moves Forward With Philip Morris iQOS
142. Kaplan, Jennifer (19 April 2018). "Philip Morris Plunges the Most in a Decade on
Review" (https://www.fool.com/investing/2017/05/26/the-fda-moves-forward-with-
Slump in Cigarettes" (https://www.bloomberg.com/news/articles/2018-04-19/philip-
philip-morris-iqos-revi.aspx). The Motley Fool.
morris-sales-disappoint-as-cigarette-demand-slips-further). Bloomberg News.
116. Lasseter, Tom; Bansal, Paritosh; Wilson, Thomas; Miyazaki, Ami; Wilson, Duff;
143. HT (1 April 2015). "High Buy: V2 Pro Series 7" (http://hightimes.com/culture/high-
Kalra, Aditya (20 December 2017). "Scientists describe problems in Philip Morris
buy-v2-pro-series-7/). High Times.
e-cigarette experiments" (https://www.reuters.com/investigates/special-
report/tobacco-iqos-science/). Reuters. 144. Kahn, Steven (11 March 2016). "V2 Pro Series 3 Vaporizer Review – Updated for
2017" (http://gazettereview.com/2016/03/v2-pro-series-3-vaporizer-vape-future/).
117. "FDA permits sale of IQOS Tobacco Heating System through premarket tobacco
Bloomberg News.
product application pathway" (https://www.fda.gov/news-events/press-
announcements/fda-permits-sale-iqos-tobacco-heating-system-through-premarket- 145. Silver, Curtis (19 May 2017). "V2 Pro Series 3X Is The Highly Versatile Vape You've
tobacco-product-application-pathway). Food and Drug Administration. 30 April 2019. Been Looking For" (https://www.forbes.com/sites/curtissilver/2017/05/19/v2-pro-
series-3x-is-the-highly-versatile-vape-youve-been-looking-for/#29cd13c347cf).
118. "Consumer-Centric Vaping" (http://www.cstoredecisions.com/2015/03/04/consumer-
Forbes.
centric-vaping/). Convenience Store Decisions. Harbor Communications. 4 March
2015. 146. Craft, Scott (16 June 2015). "V2 Pro Series 7 Review: Premium Vapor Quality From
A Surprisingly Affordable Vaporizer"
119. CSD Staff (4 March 2015). "Consumer-Centric Vaping"
(https://web.archive.org/web/20190110133642/https://www.player.one/v2-pro-
(https://cstoredecisions.com/2015/03/04/consumer-centric-vaping/). Convenience
series-7-review-premium-vapor-quality-surprisingly-affordable-vaporizer-451522).
Store Decisions. Harbor Communications.
iDigitalTimes. Archived from the original (http://www.idigitaltimes.com/v2-pro-series-
120. "The iSmoke OneHitter, iSmoke "3-in-1" and iSmoke Oven join portfolio" 7-review-premium-vapor-quality-surprisingly-affordable-vaporizer-451522) on 29
(http://www.csnews.com/product-categories/tobacco/ismoke-vapor-products? October 2017.
nopaging=1). Convenience Store News. 2017.
121. Thomas Schmid (6 March 2019). "Heat-Not-Burn: Back to Tobacco"
(https://www.tobaccoasia.com/features/heat-not-burn-back-to-tobacco). Tobacco
Asia.
147. Shi, Yuyan; Caputi, Theodore L.; Leas, Eric; Dredze, Mark; Cohen, Joanna E.; 158. Glantz, Stanton A (2018). "Heated tobacco products: the example of IQOS"
Ayers, John W. (2017). "They're heating up: Internet search query trends reveal (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252052). Tobacco Control. 27
significant public interest in heat-not-burn tobacco products" (Suppl 1): s1–s6. doi:10.1136/tobaccocontrol-2018-054601
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636077). PLOS ONE. 12 (10): (https://doi.org/10.1136%2Ftobaccocontrol-2018-054601). ISSN 0964-4563
e0185735. Bibcode:2017PLoSO..1285735C (https://www.worldcat.org/issn/0964-4563). PMC 6252052
(http://adsabs.harvard.edu/abs/2017PLoSO..1285735C). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252052). PMID 30352841
doi:10.1371/journal.pone.0185735 (https://www.ncbi.nlm.nih.gov/pubmed/30352841).
(https://doi.org/10.1371%2Fjournal.pone.0185735). ISSN 1932-6203 159. Fisher, Daniel (16 June 2014). "Philip Morris International Bets Big On The Future
(https://www.worldcat.org/issn/1932-6203). PMC 5636077 Of Smoking" (https://www.forbes.com/sites/danielfisher/2014/05/28/philip-morris-
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636077). PMID 29020019 international-bets-big-on-the-future-of-smoking/#4fa6b7e454f5). Forbes.
(https://www.ncbi.nlm.nih.gov/pubmed/29020019). This article
160. Siegel-Itzkovich, Judy (2 March 2017). "Orgs slam Litzman for allowing sale of iQOS
incorporates text (https://journals.plos.org/plosone/article/file?
heated, smokeless cigarettes" (http://www.jpost.com/Business-and-
id=10.1371/journal.pone.0185735&type=printable) by Theodore L. Caputi, Eric
Innovation/Health-and-Science/Orgs-slam-Litzman-for-allowing-sale-of-iQOS-
Leas, Mark Dredze, Joanna E. Cohen, and John W. Ayers available under the CC
heated-smokeless-cigarettes-482967). The Jerusalem Post.
BY 4.0 license.
161. Ronny Linder-Ganz (16 January 2018). "In Blow to Philip Morris, Israel to Tax iQOS
148. McNeill 2018, p. 22, 218.
E-cigarettes Like Ordinary Cigarettes" (https://www.haaretz.com/israel-
149. Tabuchi, Takahiro; Shinozaki, Tomohiro; Kunugita, Naoki; Nakamura, Masakazu; news/business/israel-to-tax-iqos-e-cigarettes-like-ordinary-cigarettes-1.5730823).
Tsuji, Ichiro (2018). "Study Profile: The Japan "Society and New Tobacco" Internet Haaretz.
Survey (JASTIS): A longitudinal internet cohort study of heat-not-burn tobacco
162. Judy Siegel-Itzkovich (3 April 2018). "Justice Ministry says iQOS product will be
products, electronic cigarettes and conventional tobacco products in Japan". Journal
treated as ordinary tobacco" (https://www.jpost.com/Business-and-
of Epidemiology. doi:10.2188/jea.JE20180116
Innovation/Health-and-Science/Justice-Ministry-says-iQOS-product-will-be-treated-
(https://doi.org/10.2188%2Fjea.JE20180116). ISSN 0917-5040
as-ordinary-tobacco-485912). The Jerusalem Post.
(https://www.worldcat.org/issn/0917-5040). PMID 30318495
(https://www.ncbi.nlm.nih.gov/pubmed/30318495). 163. "Tax hike on heat-not-burn tobacco products under consideration as LDP begins
review of tax reforms" (https://www.japantimes.co.jp/news/2017/09/08/business/tax-
150. "Japan Tobacco ratchets up smokeless war with new products"
hike-heat-not-burn-tobacco-products-consideration-ldp-begins-review-tax-
(https://nowlatestnews.com/2019/01/17/japan-tobacco-ratchets-up-smokeless-war-
reforms/#.Wb131bpFw5s). The Japan Times. 8 September 2017.
with-new-products/). Now Latest News. 17 January 2019.
164. Jae-hyuk, Park (26 May 2017). "IQOS available in Seoul Saturday"
151. Auer, Reto; Cornuz, Jacques; Berthet, Aurélie (2017). "Perplexing Conclusions
(http://www.koreatimes.co.kr/www/tech/2017/05/694_230069.html). The Korea
Concerning Heat-Not-Burn Tobacco Cigarettes—Reply"
Times.
(https://serval.unil.ch/resource/serval:BIB_4DA0DF9A988C.P001/REF.pdf) (PDF).
JAMA Internal Medicine. 177 (11): 1699–1700. 165. Trefis Team (13 September 2017). "Why Is Korea Easier To Conquer For iQOS
doi:10.1001/jamainternmed.2017.5861 Than Europe?" (http://www.nasdaq.com/article/why-is-korea-easier-to-conquer-for-
(https://doi.org/10.1001%2Fjamainternmed.2017.5861). ISSN 2168-6106 iqos-than-europe-cm845245). NASDAQ.
(https://www.worldcat.org/issn/2168-6106). PMID 29114801 166. "Singapore Enhances Tobacco Control Measures"
(https://www.ncbi.nlm.nih.gov/pubmed/29114801). (https://www.moh.gov.sg/content/moh_web/home/pressRoom/pressRoomItemRelease/2016/singapore-
152. Jane Cheung (24 May 2019). "New forms of smoking catch on" enhances-tobacco-control-measures.html). Ministry of Health (Singapore). 28 July
(http://www.thestandard.com.hk/section-news.php?id=207990). The Standard. 2016.
167. Ho, Sai Yin; Chen, Jianjiu; Leung, Lok Tung; Mok, Hoi Yan; Wang, Lijun; Wang,
153. Mathers, Annalise; Schwartz, Robert; O'Connor, Shawn; Fung, Michael; Diemert,
Man Ping; Lam, Tai Hing (2019). "Adolescent Smoking in Hong Kong: Prevalence,
Lori (2018). "Marketing IQOS in a dark market". Tobacco Control. 28 (2):
Psychosocial Correlates, and Prevention". Journal of Adolescent Health. 64 (6): S19
tobaccocontrol–2017–054216. doi:10.1136/tobaccocontrol-2017-054216
–S27. doi:10.1016/j.jadohealth.2019.01.003
(https://doi.org/10.1136%2Ftobaccocontrol-2017-054216). ISSN 0964-4563
(https://doi.org/10.1016%2Fj.jadohealth.2019.01.003). ISSN 1054-139X
(https://www.worldcat.org/issn/0964-4563). PMID 29724866
(https://www.worldcat.org/issn/1054-139X). PMID 31122545
(https://www.ncbi.nlm.nih.gov/pubmed/29724866).
(https://www.ncbi.nlm.nih.gov/pubmed/31122545).
154. Yui, Monami (28 August 2016). "Big Tobacco Wants to Turn Japan's Smokers Into
Vapers" (https://www.bloomberg.com/news/articles/2016-08-28/no-smoke-nicotine- 168. Elder, Vaughan (13 January 2017). "Legality of tobacco product in question"
hits-heat-up-japan-s-moribund-tobacco-market). Bloomberg News. (https://www.odt.co.nz/news/national/legality-tobacco-product-question). Otago
Daily Times.
155. Katz, MH; Redberg, RF (6 November 2017). "Science Requires Open Discourse".
169. Caruana, Diane (3 February 2017). "iQos heatsticks declared illegal in NZ"
JAMA Internal Medicine. 178 (1): 15–16. doi:10.1001/jamainternmed.2017.5763
(http://www.vapingpost.com/2017/02/03/iqos-heatsticks-declared-illegal-in-nz/).
(https://doi.org/10.1001%2Fjamainternmed.2017.5763). PMID 29114738
VapingPost.
(https://www.ncbi.nlm.nih.gov/pubmed/29114738).
156. Levy, David T.; Cummings, K. Michael; Villanti, Andrea C.; Niaura, Ray; Abrams, 170. "New Zealand's legal action against IQOS postponed, consultation with Big Tobacco
David B.; Fong, Geoffrey T.; Borland, Ron (2017). "A framework for evaluating the follows" (https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-
public health impact of e-cigarettes and other vaporized nicotine products" 2019/2017/vol-130-no-1465-10-november-2017/7417). 130 (1465). New Zealand
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079857). Addiction. 112 (1): 8–17. Medical Journal. 10 November 2017.
doi:10.1111/add.13394 (https://doi.org/10.1111%2Fadd.13394). ISSN 0965-2140 171. "iQOS may not be as harm-free as claimed, study finds"
(https://www.worldcat.org/issn/0965-2140). PMC 5079857 (https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=12012546). The
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079857). PMID 27109256 New Zealand Herald. 14 March 2018.
(https://www.ncbi.nlm.nih.gov/pubmed/27109256). 172. Zaharia, Marius (27 March 2018). "New Zealand court gives Philip Morris nod to sell
157. Liber, Alex C. (2018). "Heated tobacco products and combusted cigarettes: heated tobacco product" (https://www.reuters.com/article/us-newzealand-pmi/new-
comparing global prices and taxes". Tobacco Control: tobaccocontrol–2018 zealand-court-gives-philip-morris-nod-to-sell-heated-tobacco-product-
–054602. doi:10.1136/tobaccocontrol-2018-054602 idUSKBN1H333X). Reuters.
(https://doi.org/10.1136%2Ftobaccocontrol-2018-054602). ISSN 0964-4563 173. MHNZ 2017, p. ii.
(https://www.worldcat.org/issn/0964-4563). PMID 30381439
(https://www.ncbi.nlm.nih.gov/pubmed/30381439).

External links
◾ Media related to Heat-not-burn products at Wikimedia Commons

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