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Leg Pain Diagnosis

The evaluation of leg pain always begins with the health-care practitioner interviewing the patient and
performing a physical examination to help determine the potential cause of the leg pain and what direction
testing may need to take to confirm a diagnosis.

Blood tests

Infection and inflammation may be detected by blood tests, including a white blood cell count,
an erythrocyte sedimentation rate (ESR), and aC-reactive protein (CRP) measurement. These are
nonspecific tests that may give further direction to the health-care practitioner. Please note that the white
blood cell count may be elevated with an infection unless the patient has some immune compromise, at
which point it may be falsely normal. The ESR and CRP, if elevated, need to be interpreted in light of the
specific illness that is being considered.

If gout is a consideration, a blood test to measure uric acid may be done; however, in the acute attack,
the uric acid level may be high, low, or normal. The result is helpful if the level is high and may confirm a
gout flare if supported by the history and physical examination.

Other blood tests may be considered depending upon the underlying medical illnesses being considered.


• X-rays: If there is concern that a fracture or broken bone is present, plain X-rays may be
indicated. As well, X-rays may be taken as a screening to look for fluid in a joint.

• Ultrasound: Ultrasound may be helpful in making the diagnosis of deep vein thrombosis.
Superficial vein thrombosis is usually diagnosed clinically, and no imaging may be required.

• Arterial-brachial index: Arterial blood flow in the legs may be assessed by an arterial-brachial
index, in which blood flow is evaluated at rest and with exercise.

• Arteriogram: If further information is needed about the arteries, anarteriogram may be
performed to look directly at the arterial supply to the legs. This is accomplished by injecting contrast
dye directly into the arteries and watching it flow through the arteries in the legs via X-rays.
Arteriography may also be carried out using CT or MRI studies (see below).

respectively. a gram stain and culture looking for bacterial infection. tendons. a needle may be introduced to aspirate fluid for analysis. and crystal analysis looking for uric acid or calcium pyrophosphate crystals to make the diagnosis of gout or pseudogout. • Nerve conduction studies: Nerve conduction studies may be considered to evaluate nerve function and measure the ability of specific nerves to carry electrical impulses. Often this fluid is sent to a laboratory to analyze the white blood cell count within the fluid (an elevated white blood cell count may signal inflammation). looking for hidden fractures. and ligaments. CT angiography may be able to take the place of arteriography is some situations to examine blood vessels. • MRI: Magnetic resonance imaging (MRI) may be used to examine the back for the causes of sciatica to evaluate bones. (For example. MRI angiography may also be considered in place of formal angiography to evaluate blood vessels in the body.• CT scan: Computerized tomography (CT) may be used in a variety of situations. and soft tissues such as muscles. This is helpful in deciding whether nerve pain is due to a central cause from the brain or spinal cord or due to a peripheral nerve injury. CT may also be used to evaluate bone and joint anatomy. . joints. inflammation of the ulnar nerve from hitting your funny bone can cause the ring and little fingers to go numb.) • Joint aspiration: If there is concern about infection or inflammation within a joint.