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You can change string gauges or sizes before you setup your guitar.
New string gauges will just pull on the neck and bridge differently, so
it will take more work to set it up. But isn’t that what we are doing?
We are setting up your guitar the right way. Pick any string gauge you
want!
The next step is to tune your guitar. Always, always, always tune your
guitar to pitch before adjusting anything. Notice that I did not say,
“tune your guitar to standard pitch.” You should setup your guitar up
to play properly in the tuning that you normally play in. This could be
standard tuning, drop d tuning, or even DADGAD tuning. Who knows.
You will need to tighten or loosen your guitar’s truss rod to adjust the
straightness of the neck. Here is an entire article I wrote about adjust-
ing your truss rod.
My string radius adjustment page goes through the steps how to set
the string radius on every electric guitar bridge. Check it out!