You are on page 1of 163

Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list.

His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Patients less than 18 years, chronic intestinal Thiazide and other diuretic, corticosteriod,
Only for treatment of: i) Non insulin dependent diabetes
disorders associated with distinct disturbances of thyroid product, estrogens, oral contraceptives,
mellitus (NIDDM) when diet therapy is insufficient ii) Asymptomatic liver enzyme elevations especially at
Initially 50 mg daily, increase to 3 times daily up to 100 Flatulence and bowel sounds, diarrhoea and digestion and absorption, conditions which may phenytoin, nicotinic acid, sympatomimetic,
Acarbose 50 mg Tablet Glucobay Non insulin dependent diabetes mellitus (NIDDM) in higher dosages. Monitor liver enzyme during 6 - 12
mg 3 times daily. Max 200 mg 3 times daily abdominal pain deteriorate as a result of increased intestinal gas calcium channel blocker, isoniazid,
combination with existing conventional oral therapy months of treatment
formation, pregnancy, lactation, severe renal cholestyramine, intestinal absorbents, digestive
where glycaemic control is inadequate
impairment enzymes
Not generally recommended for prolonged use but if
given monitor blood count and plasma electrolyte Nausea, vomiting, diarrhoea, taste disturbances,
concentration, pulmonary obstruction (risk of loss of appetite, paraesthesia, flushing,
Reduction of intraocular pressure in open-angle Hypokalaemia, hyponatraemia, hyperchloraemic
acidosis), elderly, pregnancy and lactation, Stevens- headache, dizziness, fatigue, irritability, Aspirin, cyclosporin, digitalis , digoxin, lithium,
Acetazolamide 250 mg Tablet Diamox glaucoma, secondary glaucoma and peri-operatively in 250 - 500 mg daily acidosis, severe hepatic impairment, renal
Johnson syndrome, toxic epidermal necrosis, high- depression, thirst, polyuria, reduced libido, phenytoin, quinidine, topiramate
angle-closure glaucoma impairment, sulphonamide hypersensitivity
dose aspirin, high dose may decrease diuresis and metabolic acidosis and electrolyte disturbances
may increase drowsiness, pulmonary obstruction or on long-term therapy
emphysema

Not generally recommended for prolonged use but if


given monitor blood count and plasma electrolyte Nausea, vomiting, diarrhoea, taste disturbances,
concentration, pulmonary obstruction (risk of loss of appetite, paraesthesia, flushing,
Reduction of intra-ocular pressure in open-angle Hypokalaemia, hyponatraemia, hyperchloraemic
acidosis), elderly, pregnancy and lactation, Stevens- headache, dizziness, fatigue, irritability, Aspirin, cyclosporin, digitalis, digoxin, lithium,
Acetazolamide 500 mg Injection Diamox glaucoma, secondary glaucoma and peri-operatively in 250 - 500 mg given by IM or IV acidosis, severe hepatic impairment, renal
Johnson syndrome, toxic epidermal necrosis, high- depression, thirst, polyuria, reduced libido, phenytoin, quinidine, topiramate
angle-closure glaucoma impairment, sulphonamide hypersensitivity
dose aspirin, high dose may decrease diuresis and metabolic acidosis and electrolyte disturbances
may increase drowsiness, pulmonary obstruction or on long-term therapy
emphysema
Carbamazepine : increased risk of
Diluted with dextrose 5% and infused IV. Initial, 150
Asthma, history of bronchospasm and risk of Bronchoconstriction, nausea, vomiting, subtherapeutic carbamazepine levels.
mg/kg IV in 200 ml over 60 minutes, then 50 mg/kg IV in
Acetylcysteine 200 mg/ml Injection Parvolex Antidote for paracetamol poisoning anaphylactoid reactions and history of peptic anaphylactic reactions, rash, hypotension, Hypersensitivity to acetylcysteine products Nitroglycerin : enhanced hypotension and
500 ml over 4 hours, followed by 100 mg/kg IV in 1000
ulceration pruritus, rash, urticaria nitroglycerin-induced headache. Penicillin G,
ml over 16 hours. Total dose: 300mg/kg in 20 hour
tetracycline : loss of antibiotic efficacy
Alcohol, dipyridamole, metoclopramide,
Prevention of myocardial infarct, stroke, vascular Dyspepsia, gastric mucosal lesions, haemorrhagic Nausea, vomiting, dyspepsia, GI ulceration, metoprolol, carbonic anhydrase inhibitors,
Acetylsalicylic Acid 100 mg, Glycine
occlusion and deep vein thrombosis. Transient 1 tablet daily disorders, gout, intolerant to aspirin, renal or hepatic haematemesis, malaena. Occasionally Bleeding disorders. Hypersensitivity to salicylate corticosteroids, coumarin anticoagulants,
45 mg Tablet
ischaemic attacks impairment, asthma and G6PD deficiency hepatotoxicity sulphonylureas, methotrexate, phenytoin,
valproic acid, probenecid, sulphinpyrazone
Acetazolamide, Dipyridamol : salicylate toxicity
Gastric and duodenal ulcers, haemorrhagic (vomiting, tachycardia, hyperpnea, mental
Renal disorders, G6PD deficiency, pregnancy,
diathesis, hypersensitivity to aspirin or other confusion) or acetazolamide toxicity (fatigue,
patients with flu, chicken pox or haemorrhagic fever. Gastric haemorrhage, hypersensitivity,
NSAIDs, children under 12 years lethargy, somnolence, confusion, hyperchloremic
History of peptic ulcer or those prone to dyspepsia thrombocytopenia,GI disturbances; prolonged
Acetylsalicylic Acid 300 mg Soluble 300 - 900 mg every 4 - 6 hours as required. Max 4 g old.Hypersensitivity (attacks of asthma, metabolic acidosis). Alendronate : GI distress.
Aspirin Soluble Mild to moderate pain and those with gastric mucosal lesion; asthma or bleeding time, rhinitis, urticaria and epigastric
Tablet daily. Use in children not recommended angioedema, urticaria or rhinitis); pregnancy Antacids, calcium. Alcohol, corticosteroids,
allergic disorders; dehydrated patients; uncontrolled discomfort; angioedema, salicylism, tinnitus;
(third trimester); patients with haemophilia or phenylbutazone and oxyphenbutazone may
hypertension; impaired renal or hepatic function; bronchospasm
haemorrhagic disorders; gout; severe renal or increase risk of GI ulceration. Aspirin increases
elderly
hepatic impairment; lactation phenytoin levels. May antagonize actions of
uricosurics and spironolactone
ADULT: initially 25-30 mg daily for 2-4 weeks, then Oral contraceptives, progestogen may result in
Generalised pustular and or erythrodermic psoriasis,
adjusted according to response, usually within range 25- Symptoms of hypervitaminosis A, localized but Pregnancy and lactation, liver and kidney loss of contraceptive effectiveness. Ethanol may
pityriasis rubra pilaris, Darier's Disease, Icthyosiform Long-term treatment, diabetes, obesity, alcoholism,
Acitretin 10 mg Capsule Neotigason 50 mg daily for further 6-8 weeks (max: 75 mg daily). reversible hair loss, thinning and scaling of the insufficiency, hypervitaminosis A, excessively result in a prolonged risk of teratogenicity.
Erythrodermas - Bullous and non-bullous forms, disturbances of lipid metabolism
CHILD: 500 mcg/kg daily occasionally up to 1 mg/kg skin, paronychia, muscle and joint pain elevated blood lipid values Possible hypervitaminosis with vitamin A.
extensive naevus verrucosus, extensive psoriasis
daily to a max. 35 mg daily for limited periods Reduces protein binding of phenytoin
ADULT: initially 25-30 mg daily for 2-4 weeks, then Oral contraceptives, progestogen may result in
Generalised pustular and or erythrodermic psoriasis,
adjusted according to response, usually within range 25- Symptoms of hypervitaminosis A, localized but Pregnancy and lactation, liver and kidney loss of contraceptive effectiveness. Ethanol may
pityriasis rubra pilaris, Darier's Disease, Icthyosiform Long-term treatment, diabetes, obesity, alcoholism,
Acitretin 25 mg Capsule Neotigason 50 mg daily for further 6-8 weeks (max: 75 mg daily). reversible hair loss, thinning and scaling of the insufficiency, hypervitaminosis A, excessively result in a prolonged risk of teratogenicity.
Erythrodermas - Bullous and non-bullous forms, disturbances of lipid metabolism
CHILD: 500 mcg/kg daily occasionally up to 1 mg/kg skin, paronychia, muscle and joint pain elevated blood lipid values Possible hypervitaminosis with vitamin A.
extensive naevus verrucosus, extensive psoriasis
daily to a max. 35 mg daily for limited periods Reduces protein binding of phenytoin
Infected skin, lesions, cuts, abrasions, wounds and
Acriflavine 0.1% Lotion - Apply undiluted three times daily to the affected part . Prolonged application, may stain skin, hair & fabric. Hypersensitivity to acriflavine compound Hypersensitivity to acriflavine compound. Not known
burns.
i) ADULT: 500 mcg IV daily for max of 5 days. CHILD: Myelosuppression, nausea, vomiting, mucositis,
1.5 mg/m2 once every 3 weeks (if weight less than 10 Avoid extravasation, severe soft tissue damage. alopecia, rash, radiation recall reactions, Live vaccines may result in an increase risk of
Actinomycin D (Dactinomycin) 500 i) For solid tumours ii) Gestational trophoblastic Pregnancy, lactation, chickenpox or herpes
Cosmegen kg, 50 mcg/kg) ii) 500 mcg IV on Days 2, 4, 6, 8, 10, Concomitant radiation therapy may exaggerate hepatitis. Malaise, fatigue, fever, myalgia, infection, radiation therapy, possibly reduced
mcg/ml Injection disease zoster infection
repeat every 7 - 10 days or 500 mcg IV bolus on Days dactinomycin toxicity gastrointestinal, haematologic and dermatologic absorption of phenytoin
1 and 2, repeat every 15 days effects
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
i) Mucocutaneous Herpes Simplex infection in
immunocompromised and AIDS patients ii) Primary and
i) ADULT: initially 400 mg 5 times daily for 7 - 14 days.
recurrent Varicella Zoster infection in
CHILD less than 2 years: 200 mg 4 times daily, CHILD
immunocompromised and AIDS patients iii) Severe
more than 2 years: 400 mg 4 times daily ii), iii) and iv)
Kaposi Varicella Eruption (Eczema herpeticum) iv)
ADULT: 200 - 400 mg 4 times daily. CHILD: less than 2
Severe primary HSV infections (eg. Neonatal herpes, Patients with pre-existing neurologic, renal, or
years, half adult dose; more than 2 years, adult dose v) Increased mean half-life & plasma concentration
Acyclovir 200 mg Tablet Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to acyclovir
ADULT: 800 mg 5 times daily for 7 days vi) ADULT: 20 with probenecid
gingival stomatitis, vaginal delivery with maternal vulva lactation
mg/kg (maximum: 800 mg) four times daily for 5 days,
herpes) v) Severe and complicated varicella infection
CHILD 6 years: 800 mg four times daily. CHILD less
(eg. Encephalitis, purpura fulminans) vi) Severe zoster
than 2 years; 400mg 4 times daily, more than 2 years;
infection in paediatrics (eg. Encephalitis, purpura
800mg 4 times daily
fulminans, immunocompromised patients and facial,
sacral and motor zoster)
i) Mucocutaneous Herpes Simplex infection in
immunocompromised and AIDS patients ii) Primary and
i) ADULT: initially 400 mg 5 times daily for 7 - 14 days.
recurrent Varicella Zoster infection in
CHILD less than 2 years: 200 mg 4 times daily, CHILD
immunocompromised and AIDS patients iii) Severe
more than 2 years: 400 mg 4 times daily ii), iii) and iv)
Kaposi Varicella Eruption (Eczema herpeticum) iv)
ADULT: 200 - 400 mg 4 times daily. CHILD : less than 2
Severe primary HSV infections (eg. Neonatal herpes, Patients with pre-existing neurologic, renal, or
years, half adult dose; more than 2 years, adult dose. v) Increased mean half-life & plasma concentration
Acyclovir 200 mg/5 ml Suspension Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes, GI effects, fatigue Patients known to be hypersensitivity to acyclovir
ADULT: 800 mg 5 times daily for 7 days vi) ADULT: 20 with probenecid
gingival stomatitis, vaginal delivery with maternal vulva lactation
mg/kg (maximum: 800 mg) four times daily for 5 days,
herpes) v) Severe and complicated varicella infection
CHILD 6 years: 800 mg four times daily. CHILD: less
(eg. Encephalitis, purpura fulminans) vi) Severe zoster
than 2 years; 400mg 4 times daily, more than 2 years;
infection in paediatrics (eg.Encephalitis, purpura
800 mg 4 times daily
fulminans, immunocompromised patients and facial,
sacral and motor zoster)
ADULT: 5 mg/kg by IV infusion 8 hourly for 5 days,
doubled to 10mg/kg every 8 hourly in varicella-zoster in
the immunocompromised and in simplex encephalitis
(usually given for at least 10 days in encephalitis;
possibly for 14 - 21 days). NEONATE & INFANT up to 3
In patients receiving Zovirax IV at higher doses,
Treatment and prophylaxis of herpes simplex in months with disseminated herpes simplex: 20mg/kg
specific care regarding renal function should be Skin rashes; GI effects, neurological reactions Increased mean half-life & plasma concentration
Acyclovir 250 mg Injection Zovirax immunocompromised, severe initial genital herpes and every 8 hourly for 14 days (21 days in CNS Patients known to be hypersensitivity to acyclovir
taken, particularly when patients are dehydrated or (IV infusion) with probenecid
Varicella -Zoster involvement), varicella-zoster 10-20mg/kg every 8
have any renal impairment
hourly usually for 7 days. CHILD, 3 months - 12 years:
Herpes simplex or Varicella Zoster: 250 mg/m2 8 hourly
for 5 days, doubled to 500 mg/m2 8 hourly for varicella-
zoster in the immunocompromised and in simplex
encephalitis (usually given for 10 days in encephalitis)
Apply 1 cm 5 times daily. Continue for at least 3 days Local irritation and inflammation reported , vision
Acyclovir 3% Eye Ointment Zovirax Only for the treatment of herpes simplex keratitis Not known Hypersensitivity to acyclovir Not known
after healing abnormalities
Herpes simplex infections of the skin, including initial
Application to mucous membranes, pregnancy, Transient burning or stinging or erythema, mild
Acyclovir 5% Cream Zovirax and recurrent labial and genital herpes simplex Apply every 4 hours for 5 - 10 days Hypersensitivity to acyclovir or valacyclovir Not known
lactation. Should not be used in the eyes drying or flaking of the skin
infections
i) Mucocutaneous Herpes Simplex infection in
immunocompromised and AIDS patients ii) Primary and
i) ADULT: initially 400 mg 5 times daily for 7 - 14 days.
recurrent Varicella Zoster infection in
CHILD less than 2 years: 200 mg 4 times daily, CHILD
immunocompromised and AIDS patients iii) Severe
more than 2 years: 400 mg 4 times daily ii), iii) and iv)
Kaposi Varicella Eruption (Eczema herpeticum) iv)
ADULT: 200 - 400 mg 4 times daily. CHILD: less than 2
Severe primary HSV infections (eg. Neonatal herpes, Patients with pre-existing neurologic, renal, or
years, half adult dose; more than 2 years, adult dose v) Increased mean half-life & plasma concentration
Acyclovir 800 mg Tablet Zovirax encephalitis, eczema herpeticum, genital herpes, hepatic impairment, dehydrated patient, elderly and Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to acyclovir
ADULT: 800 mg 5 times daily for 7 days vi) ADULT: 20 with probenecid
gingival stomatitis, vaginal delivery with maternal vulva lactation
mg/kg (maximum: 800 mg) four times daily for 5 days,
herpes) v) Severe and complicated varicella infection
CHILD 6 years: 800 mg four times daily. CHILD less
(eg. Encephalitis, purpura fulminans) vi) Severe zoster
than 2 years; 400mg 4 times daily, more than 2 years;
infection in paediatrics (eg. Encephalitis, purpura
800mg 4 times daily
fulminans, immunocompromised patients and facial,
sacral and motor zoster)
Hypertension, injection site reaction, rash,
autoantibody, erythema multiforme, primary
Reactivation of tuberculosis (patients should be
cutaneous vasculitis, Stevens-Johnson
evaluated for tuberculosis before treatment), serious
Syndrome, aplastic anemia, leukopenia,
Third line treatment of: i) Severe rheumatoid arthritis ii) infection, lupus-like syndrome & confirmed
thrombocytopenia, anaphylaxis, malignant Hypersensitivity to adalimumab or any Anakinra, abatacept, live vaccine, leflunomide,
Adalimumab 40 mg Injection Humira® Psoriatic arthritis iii) Ankylosing spondylitis after failure Subcutaneous 40 mg every other week significant hematologic abnormalities, CHF &
lymphoma, multiple sclerosis, paraesthesia, component of the formulation, severe infection topical tacrolimus, trastuzumab
of conventional DMARDs or other biologics development of symptoms of blood dyscrasias,
subdural hematoma, interstitial lung disease,
women of childbearing potential, pregnancy &
angioedema, fatal infectious disease including
lactation
tuberculosis, invasive fungal infections and other
opportunistic infections
Avoid contact with eyes, lips angles of the nose and
Acne vulgaris where comedones, papules and pustules
Apply once daily to the affected areas after washing at mucosa membranes. Do not apply to cuts, abrasion, Erythema, scaling, dryness, pruritus, burning Hypersensitivity to adapalene or any of its
Adapalene 0.1% Cream Differin predominate in those sensitive to benzoyl peroxide or Methotrexate
bedtime eczematous skin or sunburned skin. Minimize sensation components
topical tretinoin [third line treatment]
exposure to slight, including sunlamps
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Avoid contact with eyes, lips angles of the nose and
Acne vulgaris where comedones, papules and pustules
Apply once daily to the affected areas after washing at mucosa membranes. Do not apply to cuts, abrasion, Erythema, scaling, dryness, pruritus, burning Hypersensitivity to adapalene or any of its
Adapalene 0.1% Gel Differin predominate in those sensitive to benzoyl peroxide or Methotrexate
bedtime eczematous skin or sunburned skin. Minimize sensation components
topical tretinoin [third line treatment]
exposure to slight including sunlamps
Monitor renal function. Patients at risk of or with
i) Treatment of chronic HBeAg positive and HBeAg underlying renal dysfunction & those receiving
negative hepatitis B infection in adults with medicine that may affect renal function. Advanced
Aminoglycosides, ibuprofen,
compensated liver function (lamivudine should be tried liver disease or cirrhosis. Patients with Renal impairment and failure, increase serum
immunosuppressant, nephrotoxic agents,
Adefovir Dipivoxil 10 mg Tablet Hepsera first) ii) Lamivudine-resistant chronic hepatitis B virus Adult over 18 years: 10mg once daily hepatomegaly, hepatitis or other known risk factors creatinine, abdominal pain, flatulence, diarrhoea, Hypersensitivity to adefovir
NSAIDs, vancomycin, ganciclovir, valganciclovir,
infection with either compensated or decompensated for liver disease. Co-infection with HIV. Congenital dyspepsia, hepatitis
ribavirin
hepatitis function (only by hepatologist and carnitine deficiency. Pregnancy & lactation. Women
gastroenterologist for approved indications) of childbearing potential must use effective
contraception
ADULT: Initially: 3 mg given as a rapid IV bolus (over 2
Facial flush, dyspnoea, a feeling of thorasic
seconds). Second dose: If the first dose does not result Avoid concomitant use of dipyridamole and
constriction, nausea, lightheadedness, feeling of Bradycardia, bronchoconstrictive or
in elimination of the supraventricular tachycardia with in methylxanthines (eg: caffeine, theophylline). Cardiac
discomfort, sweating, palpitations, bronchospastic lung disease (eg. asthma). Actions may be potentiated by dipyridamole and
Rapid conversion of paroxysmal supraventricular 1 or 2 minutes, 6 mg should be given also as a rapid IV arrest, heart block, heart transplant patients,
Adenosine 3 mg/ml Injection Adenocor hyperventilation, head pressure, apprehension, Hypersensitivity to adenosine, second-degree or carbamazepine. Theophylline & caffeine inhibit
tachycardia to sinus rhythm bolus. Third dose: If the second dose does not result in hypertension, hypotension, myocardial infarction.
blurred vision, burning sensation, bradycardia, third-degree AV block (unless pacemaker fitted), its action
elimination of the supraventicular tachycardia with in 1- Proarrhythmic events; new rhythms, particularly at
chest pains, headache, dizziness, heaviness in sinus node disease (eg. sick sinus syndrome)
2 minutes, 12 mg should be given also as a rapid IV time of conversion and unstable angina
arms, arm, back and neck pains; metallic taste
bolus
Cardiac dilatation, coronary insufficiency. Within
2 weeks of MAOI use.Organic brain damage,
Elderly patients, patients with; CV disease, narrow-angle glaucoma. Shock. Concurrent use
Beta-blocking,alpha-adrenergic blockers
pulmonary oedema, hypertension, hyperthyroidism, with local anesthetics for injection of certain
agents,antihistamines,tricyclic antidepressants
Adrenaline Acid (Epinephrine) diabetes, psychoneurotic illness, asthma, Hypertension, arrhythmias, nausea, vomiting, areas (eg; fingers, toes, ears); increased risk of
- Cardiopulmonary resuscitation 0.5-1 mg given by SC or IM carvedilol, chlorpromazine, halothane,
Tartrate 1 mg/ml Injection prefibrillatory rhythm, or anesthetic cardiac acidents. headache, shortness of breath, sneezing vasoconstriction and sloughing of tissue.
moclobemide, rocuronium, selegiline,
Bronchial asthma/emphysema,cerebrovascular oncurrent use with cyclopropane or halogenated
timolol,methyldopa, diuretics, oxytoxic drugs
hemorrhage, pregnancy, lactation, children hydrocarbon anaesthetics; may produce fatal
ventricular arrhythmias. Labor; may delay the
second stage
Gastrointestinal discomfort, dizziness, headache,
Discontinue therapy if liver function test elevations Patients with hypersensitivity to albendazole or
i) ADULT and CHILD over 2 years : 400 mg as a single erythema multiforme, Stevens-Johnson Concurrent use with dexamethasone may result
i) Single or mixed infestations of intestinal parasites ii) are significant, retinal lesions, cerebral hypertensive to the benzimidazole drug class, pregnancy
Albendazole 200 mg Tablet Zentel dose ii) 400 mg as a single dose for 3 consecutive syndrome, agranulocytosis, aplastic anemia, in an increased risk of albendazole adverse
Strongyloides infection episodes, pregnancy, hepatic disease, retinal (avoid pregnancy for at least one month following
days. CHILD 12 - 24 months : half adult dose leukopenia, pancytopenia, thrombocytopenia, effects.
lesions therapy)
hepatotoxicity
Gastrointestinal discomfort, dizziness, headache,
Discontinue therapy if liver function test elevations Patients with hypersensitivity to albendazole or
i) ADULT and CHILD over 2 years : 400 mg as a single erythema multiforme, Stevens-Johnson Concurrent use with dexamethasone may result
i) Single or mixed infestations of intestinal parasites ii) are significant, retinal lesions, cerebral hypertensive to the benzimidazole drug class. Pregnancy
Albendazole 200 mg/5 ml Suspension Zentel dose ii) 400 mg as a single dose for 3 consecutive syndrome, agranulocytosis, aplastic anemia, in an increased risk of albendazole adverse
Strongyloides infection episodes, pregnancy, hepatic disease, retinal (avoid pregnancy for at least one month following
days. CHILD 12 - 24 months : half adult dose leukopenia, pancytopenia, thrombocytopenia, effects
lesions therapy)
hepatotoxicity
Mental impairment, gastrointestinal disturbances,
Chlorpropamide, metronidazole, cefoperazone,
Alcohol 70% Solution - Use as antiseptic and disinfectant Apply to the skin undiluted or when needed Pregnancy, nursing mothers, elderly severe effects include respiratory depression, Not known
cefoperazone/sulbactam and cefotaxime
coma and death
70 mg once weekly. Swallow the tablet whole with a full
Concurrent use with aspirin and mesalamine
Osteoporosis in post menopausal women with a history glass of plain water only on an empty stomach at least Creatinine clearance less than 35 ml/min, vitamin D Oesophageal reactions, abdominal Hypersensitivity to alendronate products,
may result in gastrointestinal distress.
Alendronate Sodium 70 mg Tablet Fosamax of vertebral fracture and whom oestrogen replacement 30 minutes before breakfast (and any other oral and mineral deficiencies to be corrected before pain,musculoskeletal hypocalcaemia, esophageal abnormalities,
Concurrent use with calcium and antacids may
therapy is contraindicated medication); stand or sit upright for at least 30 minutes initiating therapy pain,headache,diarrhoea,constipation inability to stand or sit upright for 30 minutes
result in reduced alendronate absorption
and do not lie down until after eating breakfast

Discontinue in case of dysphagia, odynophagia, Urticaria, myalgia, malaise; nausea, vomiting,


Esophageal abnormalities which inhibit
1 tablet once weekly [contains cholecalciferol 2800 retrosternal pain or new or worsening heartburn. esophageal stricture/perforation, oropharyngeal
esophageal emptying (ie, achalasia, stricture),
units in a weekly dose, equivalent to 400 units daily]. Active upper gastrointestinal problems (dysphagia, ulceration; esophagitis, esophageal erosions,
increased risk for adverse esophageal effects, Calcium supplements, antacids. Hormone
Osteoporosis in post menopausal women with a history Swallow the tablet whole with a full glass of plain water esophageal diseases, gastritis, duodenitis or ulcers). esophageal ulcers; localized osteonecrosis of
Alendronate Sodium 70mg and hypocalcemia; decreases in serum calcium and replacement therapy. Olestra, mineral oils,
Fosamax Plus of vertebral fracture and whom oestrogen replacement only on an empty stomach at least 30 minutes before CrCl less 35 ml/min. Correct hypocalcemia and other the jaw; bone, joint and or muscle pain; rash,
Cholecalciferol 2800 IU Tablet phosphate have occurred during therapy, orlistat, cholestyramine, colestipol.
therapy is contraindicated breakfast (and any other oral medication); stand or sit disorders affecting mineral metabolism (eg vit D pruritus, angioedema, fever, hypocalcemia,
resolve hypocalcemia prior to beginning therapy, Anticonvulsants, cimetidine, thiazides
upright for at least 30 min and do not lie down until after deficiency) before starting therapy. Monitor serum gastric or duodenal ulcers, Stevens-Johnson
inability to sit or stand in an upright position for at
eating breakfast Calcium and urine. Children, pregnancy and syndrome, toxic epidermal necrolysis, ocular
least 30 minutes
lactation inflammations (uveitis, iritis, scleritis)
Treatment of: i) Renal osteodystrophy in patients on
Initial dose ADULT and CHILD above 20kg body weight
haemodialysis ii) Hypoparathyroidism and Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
: 1 mcg daily; CHILD under 20kg body weight : 0.05 Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 0.25 mcg Capsule One-alpha pseudohypoparathyroidism iii) Adjunct to the plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
mcg/kg/day. Maintenance dose : 0.25 mcg to 2 mcg polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products.
daily
and osteomalacia v) Osteoporosis
Treatment of: i) Renal osteodystrophy in patients on
Initial dose ADULT and CHILD above 20kg body weight
haemodialysis ii) Hypoparathyroidism and Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
: 1 mcg daily; CHILD under 20kg body weight : 0.05 Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 1 mcg Capsule one-alpha pseudohypoparathyroidism iii) Adjunct to the plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
mcg/kg/day. Maintenance dose : 0.25 mcg to 2 mcg polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products
daily
and osteomalacia v) Osteoporosis
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Treatment of: i) Renal osteodystrophy in patients on
haemodialysis ii) Hypoparathyroidism and Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 2 mcg/ml Drops One-Alpha pseudohypoparathyroidism iii) Adjunct to the NEONATES : 0.1 mcg/kg/day plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
polyuria
management of tertiary hyperparathyroidism iv) Rickets titration products
and osteomalacia v) Osteoporosis
Treatment of: i) Renal osteodystrophy in patients on
haemodialysis ii) Hypoparathyroidism and Initial dose : 1 mcg per haemodialysis. Maximum dose Take care to ensure correct dose to infants, monitor Hypercalcaemia, metastatic calcification, vitamin
Hypercalcaemia, nausea, vomiting, polydipsia,
Alfacalcidol 2 mcg/ml Injection One-Alpha pseudohypoparathyroidism iii) Adjunct to the 6 mcg per haemodialysis and not more than 12 mcg plasma calcium and creatinine during dosage D toxicity and hypersensitivity to calcitriol Antiepileptics, diuretics, barbiturates
polyuria
management of tertiary hyperparathyroidism iv) Rickets per week titration. products
and osteomalacia v) Osteoporosis
Continuous monitoring of vital signs. Initial dose
reduction in the elderly and debilitated. Impaired
hepatic or renal function. Concurrent diazepam may
produce vasodilation and hypotension; resulting in
Diltiazem, fluconazole : prolonged alfentanil
delayed recovery. Head injury, increased intracranial
Hypersensitivity to alfentanil and other opioids. efficacy. Erythromycin : decreased alfentanil
pressure. Pulmonary disease, decreased respiratory
Tacycardia, bradyarrhythmia, cardiac Intolerance to morphinomimetics. In labor or clearance. Itraconazole : increased alfentanil
reserve. Decreased respiratory reserve and
dysrhythmia, hypertension, hypotension, before clamping of the cord during caesarean serum concentrations and potential alfentanil
For use as short acting narcotic analgesic in short Initial dose: 20 - 40 mcg/kg. Supplemental dose: 15 pulmonary disease; prostatic hyperplasia;
Alfentanil HCl 0.5 mg/ml Injection Rapifen respiratory depression, apnoea, muscular section. Respiratory depression and obstructive toxicity (CNS depression, respiratory
procedures and day-care surgical procedures mcg/kg or infusion 0.5 - 1.0 mcg/kg/min hypotension; shock; inflammatory or obstructive
rigidity, dizziness, nausea, CNS disturbances, airways disease; acute alcoholism, convulsive depression). Naltrexone : precipitation of opioid
bowel disorders; myasthenia gravis; hypovolaemia;
vomiting and constipation disorders; head injuries, and conditions in which withdrawal symptoms. Monoamine oxidase
uncontrolled hypothyroidism; alcoholism; chronic
intracranial pressure is raised inhibitors (MAOIs), alcohol and central nervous
opioid therapy and history of opioid abuse. Avoid
system depressants
rapid bolus Injection in compromised intracerebral
compliance. Do not administer during the last 10
minutes of surgery. Pregnancy and lactation. May
affect ability to drive and operate machinery
Gastrointestinal disturbances, vertigo, malaise,
Orthostatic hypotension, hepatic insufficiency,
Elderly, coronary insufficiency, discontinue in the dizziness, headache. Rarely orthostatic
Treatment of functional symptoms related with benign severe renal insufficiency (CrCl less than 30
Alfuzosin HCl 10 mg Tablet Xatral XL 10 mg once a day pre bed event of recurrence or exacerbation of angina, may hypotension, syncope, tachycardia, palpitations, Alpha blockers and other antihypertensives
prostatic hypertrophy (BPH) ml/min), intestinal occlusion. Avoid combination
impair ability to drive or operate machinery chest pain, asthenia, drowsiness, oedema,
with alpha blockers
flushing, dry mouth, rash, pruritis
To be diluted with an equal volume of warm water Epistaxis, not to be used in cranial surgery or trans
Alkaline Nasal Douche To remove nasal plug due to radiation Excessive use can be toxic due to its absorption Not known Not known
before use nasal neuro surgical procedure
Skin rash, maculopapular, pruritic, Stevens-
Johnson Syndrome, peripheral neuritis, alopecia,
Oral anticoagulants, azathioprine, antidiabetics,
GI upset, toxic epidermal necrolysis. Acute
mercaptopurine.Use only quarter of the usual
attack of gouty arthritis in early stages of therapy. Hypersensitivity to allopurinol, pregnancy,
Initial dose : 100-300 mg daily. Maintenance : 300-600 Renal/hepatic dysfunction, asymptomatic dose of 6-mercaptopurine or azathioprine when
Allopurinol 100 mg Tablet Gout or uric acid and calcium oxalate renal stones Skin reactions (discontinue immediately at first lactation, acute gout, asymptomatic
mg daily. Maximum: 900 mg daily hyperuricaemia, hypersensitivity and pregnancy given concurrently. Increases plasma half-life of
sign of rash). Very rarely, granulomatous hyperuricaemia
adenine arabinoside. Effects decreased by
hepatitis. Occasionally; thrombocytopenia,
uricosurics & large doses of salicylates
agranulocytosis, & aplastic anaemia in patients
with impaired renal function
Skin rash, maculopapular, pruritic, Stevens-
Johnson Syndrome, peripheral neuritis, alopecia,
Oral anticoagulants, azathioprine, antidiabetics,
GI upset, toxic epidermal necrolysis. Acute
mercaptopurine.Use only quarter of the usual
attack of gouty arthritis in early stages of therapy. Hypersensitivity to allopurinol, pregnancy,
Initial dose : 100-300 mg daily. Maintenance : 300-600 Renal/hepatic dysfunction, asymptomatic dose of 6-mercaptopurine or azathioprine when
Allopurinol 300 mg Tablet Zyloric Gout or uric acid and calcium oxalate renal stones Skin reactions (discontinue immediately at first lactation, acute gout, asymptomatic
mg daily. Maximum: 900 mg daily hyperuricaemia, Hypersensitivity and pregnancy given concurrently. Increases plasma half-life of
sign of rash). Very rarely, granulomatous hyperuricaemia
adenine arabinoside. Effects decreased by
hepatitis. Occasionally; thrombocytopenia,
uricosurics & large doses of salicylates
agranulocytosis, & aplastic anaemia in patients
with impaired renal function
Headache, fever, weakness, fatigue, nausea,
Concurrent use with drugs which inhibit hepatic
vomiting, dry skin, rash, peripheral oedema,
cytochrome P450 enzyme system, eg
Avoid pregnancy during and for at least 1 month mycosis, conjunctivitis, hypotension,
ketoconazole, cimetidine, ciclosporin, diltiazem,
after stopping treatment. Monitor haematological, hypertension, arrhythmias, heart failure, flushing,
Induction: 45 mg/m2 daily for 30 - 90 days. erythromycin, rifampicin, verapamil may increase
All-Trans Retinoic Acid 10 mg coagulation profile, liver function test, serum lipid dizziness, anxiety, depression, paresthesias, Hypersensitivity to retinoids, pregnancy and
Vesanoid Acute promyelocytic leukaemia Maintenance: 45 mg/m2 daily for 2 weeks every 3 risk of toxicity. Use together with vitamin A
Capsule levels. To be used with caution in pre-existing confusion, pseudotumour cerebri, lactation
months. Refer to protocols supplements may result in increase in toxicity.
hypertriglyceridaemia, diabetes mellitus, obesity. gastrointestinal bleeding, abdominal pain,
Avoid ethanol. Exposure to paclitaxel result in
Anticipate and treat retinoic acid syndrome diarrhoea, constipation, retinoic acid syndrome,
increased risk of paclitaxel toxicity. Tranexamic
bone pain, muscle pain, joint pain, increase in
Acid may result in increased risk of thrombosis
serum triglycerides and cholesterol
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Ketoconazole, fluconazole, itraconazole,
contraceptives; increased alprazolam serum
concentrations and potential alprazolam toxicity
(sedation, slurred speech, CNS depression).
Omeprazole, erythromycin, clarithromycin,
cimetidine; benzodiazepine toxicity (CNS
depression, ataxia, lethargy). Sertraline,
Drowsiness, blurred vision, coordination
increased risk of psychomotor impairment and
disorder, gastrointestinal disturbance, agitation,
Avoid operating vehicles or machinery, abuse prone sedation. Fluoxetine, increased risk of
lightheadedness, dry mouth, depression,
0.25 - 0.5 mg 3 times daily (elderly or delibitated 0.25 patient, pregnancy and breastfeeding, renal or Hypersensitivity to benzodiazepines, acute alprazolam toxicity (somnolence, dizziness,
headache, confusion, hypotension, syncope,
Alprazolam 0.25 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
tachycardia, seizures, respiratory depression,
dose of 3 mg/day. Not recommended for children untreated open angle glaucoma, impaired pulmonary ketoconazole/ itraconazole, CNS depression psychomotor impairment). Fluvoxamine,
coma, constipation, diarrhoea, nausea, vomiting,
function. Prolonged use can lead to dependence increased risk of CNS side effects. Ritonavir,
insomnia, nasal congestion, rigidity, increased
increased plasma concentrations of alprazolam
salivation, dermatitis, sedation
and enhanced alprazolam effects.
Antihistamine/decongestant combinations,
antipsychotic, ethanol, mirtazapine,
phenothiazines, venlafaxine (increased risk of
CNS depression, psychomotor impairment),
sedative/hypnotics, tricyclic antidepressants
(CNS depression)
Ketoconazole, fluconazole, itraconazole,
contraceptives; increased alprazolam serum
concentrations and potential alprazolam toxicity
(sedation, slurred speech, CNS depression).
Omeprazole, erythromycin, clarithromycin,
cimetidine; benzodiazepine toxicity (CNS
depression, ataxia, lethargy). Sertraline,
Drowsiness, blurred vision, coordination
increased risk of psychomotor impairment and
disorder, gastrointestinal disturbance, agitation,
Avoid operating vehicles or machinery, abuse prone sedation. Fluoxetine, increased risk of
lightheadedness, dry mouth, depression,
0.25 - 0.5 mg 3 times daily (elderly or delibitated 0.25 patient, pregnancy and breastfeeding, renal or Hypersensitivity to benzodiazepines, acute alprazolam toxicity (somnolence, dizziness,
headache, confusion, hypotension, syncope,
Alprazolam 0.5 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
tachycardia, seizures, respiratory depression,
dose of 3 mg/day. Not recommended for children untreated open angle glaucoma, impaired pulmonary ketoconazole/ itraconazole, CNS depression psychomotor impairment). Fluvoxamine,
coma, constipation, diarrhoea, nausea, vomiting,
function. Prolonged use can lead to dependence increased risk of CNS side effects. Ritonavir,
insomnia, nasal congestion, rigidity, increased
increased plasma concentrations of alprazolam
salivation, dermatitis, sedation
and enhanced alprazolam effects.
Antihistamine/decongestant combinations,
antipsychotic, ethanol, mirtazapine,
phenothiazines, venlafaxine (increased risk of
CNS depression, psychomotor impairment),
sedative/hypnotics, tricyclic antidepressants
(CNS depression)
Ketoconazole, fluconazole, itraconazole,
contraceptives; increased alprazolam serum
concentrations and potential alprazolam toxicity
(sedation, slurred speech, CNS depression).
Omeprazole, erythromycin, clarithromycin,
cimetidine; benzodiazepine toxicity (CNS
depression, ataxia, lethargy). Sertraline,
Drowsiness, blurred vision, coordination
increased risk of psychomotor impairment and
disorder, gastrointestinal disturbance, agitation,
Avoid operating vehicles or machinery, abuse prone sedation. Fluoxetine, increased risk of
lightheadedness, dry mouth, depression,
0.25 - 0.5 mg 3 times daily (elderly or delibitated 0.25 patient, pregnancy and breastfeeding, renal or Hypersensitivity to benzodiazepines, acute alprazolam toxicity (somnolence, dizziness,
headache, confusion, hypotension, syncope,
Alprazolam 1 mg Tablet Xanax Anxiety disorders mg 2-3 times daily), increased if necessary to a total hepatic dysfunction, elderly patients, obesity, narrow angle glaucoma, concomitant use of ataxia, slurred speech, hypotension,
tachycardia, seizures, respiratory depression,
dose of 3 mg/day. Not recommended for children untreated open angle glaucoma, impaired pulmonary ketoconazole/ itraconazole, CNS depression psychomotor impairment). Fluvoxamine,
coma, constipation, diarrhoea, nausea, vomiting,
function. Prolonged use can lead to dependence increased risk of CNS side effects. Ritonavir,
insomnia, nasal congestion, rigidity, increased
increased plasma concentrations of alprazolam
salivation, dermatitis, sedation
and enhanced alprazolam effects.
Antihistamine/decongestant combinations,
antipsychotic, ethanol, mirtazapine,
phenothiazines, venlafaxine (increased risk of
CNS depression, psychomotor impairment),
sedative/hypnotics, tricyclic antidepressants
(CNS depression)
For treatment of congenital heart diseases which are 0.05 - 0.1 mcg/kg/min by continuous IV infusion, then Concurrent anticoagulants, neonates with bleeding Bradycardia, fever, hypotension, tachycardia,
Alprostadil 500 mcg/ml Injection Prostin VR Neonates with respiratory distress syndrome Heparin
ductus arteriosus dependent decreased to lowest effective dose tendencies, spinal cord injury neonatal apnoea, seizures
Aluminium Acetate 5% Lotion - Weeping eczema Use undiluted freshly prepared as soaks Broken or irritated skin Hypersensitivity Hypersensitivity to any component Not known
Major: phosphate binders and citrates may
increase serum aluminum concentrations
Hypophosphataemia, porphyria, end-stage renal
(toxicity);sodium polystyrene sulfonate (systemic
600 mg- 1.2 g 4 times daily and at bedtime or as Chronic renal failure, may cause phosphate disease. Risk of developing hyperaluminemia
Aluminium Hydroxide 600 mg Tablet Alutab Dyspepsia, hyperphosphataemia Constipation alkolosis). Minor: Affects absorption of
required depletion and encephalopathy (fatalities have been
tetracyclines, penicillins, sulfonamides, quinidine,
reported)
iron, digoxin, indomethacin, naproxen,
phenylbutazon
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Oedema of ankles, livedo reticularis, depression,
Seizure disorder, psychiatry disorder, recurrent hallucination, nausea, vomiting, dizziness, Alcohol, methyldopa, metoclopramide,
Initial dose: 100 mg daily and is increased to 100 mg
eczema, gastric ulceration. Patients with insomnia, blurred vision, dry mouth. Seizures, Hypersensitivity to amantadine products, domperidone, antipsychotic, antimuscarinics.
twice daily (not later than 4 p.m.) after a week. Elderly
Amantadine HCl 100 mg Capsule Symmetrel Parkinson's disease cardiovascular or liver disease, impaired renal psychosis, confusion, ataxia, heart failure, pregnancy, lactation, epilepsy, history of gastric Enhances the adverse effects of antimuscarinics
over 65 years: less than 100 mg or 100 mg at intervals
function. Elderly. Withdrawal of the drug should be depression, orthostatic hypotension, blood ulceration, severe renal impairment and levodopa. Central nervous system
of more than 1 day
gradual dyscrasias, urinary retention, irritability, stimulants, drugs that raise urinary pH
gastrointestinal disturbances
Potentiation of toxicity in combination with loop
ADULT: (IM or IV): 15 mg/kg/day 8 - 12 hourly for 7 - 10
Myasthenia gravis, renal impairment, pregnancy and diuretics, cephalothin, vancomycin, cyclosporin.
days. Maximum: 1.5 g/day. CHILD: 15 mg/kg/day 8 - 12 Ototoxicity and nephrotoxicity, rarely skin rash,
lactation. Tinnitus or vertigo may be indications of Prolongs action of neuromuscular blockers.
Amikacin 250 mg/2 ml Injection Amikin Infections due to susceptible organisms hourly. Maximum: 1.5 g/day. Neonates: Initial loading fever, paraesthesia, athralgia, anaemia, Hypersensitivity to aminoglycosides
vestibular injury and impending bilateral irreversible Increased risk of respiratory depression with
dose of 10 mg/kg followed by 7.5 mg/kg/day 12 hourly. hypotension
damage either halothane, methoxyflurane &
Maximum 15mg/kg/day
neuromuscular blockers
Potentiation of toxicity in combination with loop
ADULT: (IM or IV): 15 mg/kg/day 8 - 12 hourly for 7 - 10
Myasthenia gravis, renal impairment, pregnancy and diuretics, cephalothin, vancomycin, cyclosporin.
days. Maximum: 1.5 g/day. CHILD: 15 mg/kg/day 8 - 12 Ototoxicity and nephrotoxicity, rarely skin rash,
lactation. Tinnitus or vertigo may be indications of Prolongs action of neuromuscular blockers.
Amikacin 500 mg/2 ml Injection Amikin Infections due to susceptible organisms hourly. Maximum: 1.5 g/day. Neonates: Initial loading fever, paraesthesia, athralgia, anaemia, Hypersensitivity to aminoglycosides
vestibular injury and impending bilateral irreversible Increased risk of respiratory depression with
dose of 10 mg/kg followed by 7.5 mg/kg/day 12 hourly. hypotension
damage either halothane, methoxyflurane &
Maximum 15mg/kg/day
neuromuscular blockers
Angiotensin converting enzyme inhibitors:
postural hypotension (first dose).
Diabetes mellitus. Electrolyte imbalance,
Carbamazepine: hyponatraemia.
concomitant use of other diuretics can result in
Chlorpropamide: decreased chlorpropamide
i) Initially 1 - 2 tab daily adjusted according to response. hyponatraemia and hypochloremia as well as Hypersensitivity to hydrochlorothiazide/amiloride
Amiloride HCl 5 mg & i) Diuretic as an adjunct to the management of Hyperkalaemia, rash, dizziness, headache, effectiveness. Digitalis: digitalis toxicity (nausea,
Moduretic Max : 4 tabs daily. ii) 1 -2 tabs daily as a single or increases in BUN levels. This is more frequent in or sulfonamides, hyperkalaemia, anuria, renal
Hydrochlorothiazide 50 mg Tablet oedematous states ii) Hypertension asthenia vomiting, arrhythmias). Corticosteroids:
divided dose patients with hepatic cirrhosis and ascites, metabolic failure
hypokalaemia and subsequent cardiac
alkalosis or those with resistant oedema. Metabolic
arrhythmias. NSAIDs: decreased diuretic and
or respiratory acidosis
antihypertensive efficacy. Propranolol:
hyperglycaemia, hypertriglyceridemia
Dose to be individualised. ADULT usually 500-2000 ml Patients with inborn errors of amino acid
Gastrointestinal upset, flushing, sweating,
Amino Acids Injection Vamin Source of amino acids in patients needing IV nutrition by IV. ADULT usual requirement for amino acid: 1-2 Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
thrombophlebitis
g/kg/day uraemia without dialysis
Patients with inborn errors of amino acid
Source of amino acids and electrolytes in patients Dose to be individualised. ADULT usual requirement for Gastrointestinal upset, flushing, sweating,
Amino Acids with Electrolytes Injection - Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
needing IV nutrition amino acid 1-2 g/kg/day thrombophlebitis
uraemia without dialysis
Patients with inborn errors of amino acid
Amino Acids with Glucose with Source of amino acids, carbohydrate and electrolytes Dose to be individualised. ADULT usual requirement for Hyperammonemia, encephalopathy, cholestasis,
Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection in patients needing IV nutrition amino acid 1-2 g/kg/day, carbohydrate 4-6 g/kg/day thrombophlebitis
uraemia without dialysis
Patients with inborn errors of amino acid
Amino Acids with Glucose without Source of amino acids and carbohydrate in patients Dose to be individualised. ADULT usual requirement for Hyperammonemia, encephalopathy, cholestasis,
- Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection needing IV nutrition amino acid 1-2 g/kg/day, carbohydrate 4-6 g/kg/day thrombophlebitis
uraemia without dialysis
Dose to be individualised. ADULT: 500 - 2000 ml daily
Patients with inborn errors of amino acid
Amino Acids, Glucose and Lipid with Source of amino acids, carbohydrate, lipid and given by IV. ADULT usual requirement for amino acid 1- Gastrointestinal upset, flushing, sweating,
- Liver disease, renal impairment metabolism, irreversible liver damage, severe Not known
Electrolytes Injection electrolytes in patients needing IV nutrition 2 g/kg/ day, carbohydrate 4-6 g/kg/day, lipid 2-3 thrombophlebitis
uraemia without dialysis
g/kg/day
Drowsiness, lethargy, ataxia, fever, skin rashes
and gastrointestinal disturbances. Bone-marrow
Increased metabolism of synthetic
0.5 - 1 g/day. With hydrocortisone 30 mg/day or Monitor blood pressure, adrenal and thyroid function. depression with leucopenia, thrombocytopenia,
Only for the treatment of hormone-responsive breast Porphyria, pregnancy, hypersensitivity to glucocorticoids, warfarin and other oral
Aminoglutethimide 250 mg Tablet Orimetene cortisone acetate 37.5 mg/day to prevent adrenal Periodic blood counts. May impair ability to drive and agranulocytosis or severe pancytopenia. Adrenal
cancer aminoglutethimide anticoagulants, theophylline,
insufficiency operate machinery. Not recommended in lactation insufficiency and other endocrine disturbances
medroxyprogesterone and oral antidiabetics
including hypothyroidism and virilisation.
Orthostatic hypotension
Hyperthyroidism, glaucoma, diabetes mellitus,
angina pectoris, pulmonary, cardiovascular, renal or
hepatic diseases. Pregnancy, children and elderly.
Deteriorating acute asthma not previously treated with Active peptic ulcer disease, seizure disorders,
theophylline, by slow IV injection over 20 minutes 250 - cardiac arrhythmias (not including Tachycardia, palpitations, nausea and other
Azole antifungals, ciprofloxacin, clarithromycin,
500 mg (5 mg/kg), then as for acute severe asthma. bradyarrhythmias). Patients with migraine gastrointestinal disturbances, headache, CNS
Hypersensitivity to theophylline or derivatives, erythromycin : increased risk of theophylline
Aminophylline 25 mg/ml Injection - Reversible airways obstruction, acute severe asthma Acute severe asthma by IV infusion : 500 mcg/kg/hour, headaches may experience an increased frequency stimulation, insomnia, arrythmias, also allergy to
hypersensitivity to ethylenediamine toxicity. Caffeine : increased caffeine level.
adjusted according to plasma-theophylline of headaches. Patients with congestive heart failure, ethylenediamine which can cause urticaria,
Halothane : increased risk of arrthmia
concentration. CHILD : 6 month - 9 years : 1 cor pulmonale, prolonged fever, hypothyroidism, erythema, and exfoliative dermatitis
mg/kg/hour, 10 - 16 years : 800 mcg/kg/hour liver disease, sepsis with multi-organ failure, and
shock may require reduced theophylline dosage.
Concommitant medication use which results in
reduced theophylline clearance
Acute myocardial infarction, sino-atrio, block AV or
Reversible corneal microdeposits; colored halos. Antiarrhythmics, beta-blockers, stimulating
Initial infusion of 5mg/kg via large venous access over other severe conduction disorder ( unless the patient Cardiogenic shock, hypersensitivity to
Hyper or hypothyroidism. Rarely; laxatives, diuretics inducing hypokalaemia,
Arrhythmias when other drugs are contraindicated or 20-120 minutes with ECG monitoring; subsequent has a pacemaker),severe hypotension,severe amiodarone, second or third degree AV block (if
Amiodarone 150mg/3 ml Injection Cordarone photosensitization and pigmentation. Reversible systemic corticosteroids, tetracosactide,
ineffective infusion given if necessary according to response up to respiratory failure, bradycardia, no pacemaker is present). Severe sinus
diffuse interstitial pneumopathy or peripheral amphotericin B, digitalis, anticoagulants,
a maximum of 1.2 g in 24 hours cardiomegaly,corneal microdeposits (impaired bradycardia and severe sinus-node dysfunction
neuropathy phenytoin, general anaesthetic, ciclosporin
vision)
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Acute myocardial infarction, sino-atrio, block AV or Reversible corneal microdeposits; colored halos. Antiarrhythmics, beta-blockers, stimulating
200 mg 3 times daily for 1 week, then reduced to 200 Cardiogenic shock, hypersensitivity to
other severe conduction disorder (unless the patient Hyper or hypothyroidism. Rarely; laxatives, diuretics inducing hypokalaemia,
mg twice daily for another week. Maintenance dose, amiodarone, second or third degree AV block (if
Amiodarone 200 mg Tablet Cordarone Arrhythmias has a pacemaker),severe hypotension,severe photosensitization and pigmentation. Reversible systemic corticosteroids, tetracosactide,
usually 200 mg daily or the minimum required to control no pacemaker is present). Severe sinus
respiratory failure,bradycardia, cardiomegaly, diffuse interstitial pneumopathy or peripheral amphotericin B, digitalis, anticoagulants,
the arrhythmia bradycardia and severe sinus-node dysfunction
corneal microdeposits (impaired vision) neuropathy phenytoin, general anaesthetics, ciclosporin

Barbiturate, phenytoin, carbamazepine,


cimetidine, amphetamines, antiarrhythmics, class
Ia and III, anticholinergics, antihistamines, beta 2
Dry mouth, constipation, nausea, vomiting,
agonists, benzodiazepines, systemic carbonic
Cardiac disease, hyperthyroidism, impaired hepatic urinary retention, blurred vision, drowsiness,
anhydrase inhibitors, central alpha 2 agonists,
Initially 75 mg. ADULT and ELDERLY : 30 - 75 mg daily and renal function, urinary retention, history of dizziness, tachycardia, increased appetite,
Hypersensitivity to drug/class. Immediate cholinergic agents, clozapine, intranasal
in divided doses or as a single dose at bedtime, seizures, glaucoma, suicide risk, pregnancy, confusion, seizures, myocardial infarction,
Amitriptyline HCl 25 mg Tablet Laroxyl Depression recovery phase after myocardial infarction, heart decongestants, flumazenil, halothane, lithium,
increase gradually as necessary to 150 - 200 mg. lactation, elderly, phaeochromocytoma, history of stroke, agranulocytosis, thrombocytopenia, rash
block, mania. MAOI use within the last 14 days MAOIs, methylphenidate, metoclopramide,
CHILD under 16 years are not recommended mania, phychoses, angle-closure glaucoma, and hypersensitivity reactions, blood sugar
muscle relaxants, nitrates, opiates,
concurrent anticonvulsive therapy, anaesthesia changes, endocrine side effects, impotence,
antipsychotics, phenytoin, protease inhibitors,
menstrual irregularities, bone marrow depression
sedatives/hypnotics, SSRIs, indirect/mixed
sympathomimetics, cimetidine, fluoxetine,
clonidine
Nasopharyngitis, flu, headache, oedema,
peripheral oedema, fatigue, flushing, asthenia,
Risk of hypotension in sodium or volume depleted vertigo, tachycardia, palpitations, orthostatic
patient, beta blocker withdrawal should be gradual. hypotension, cough, pharyngolaryngeal pain,
Doses range from amlodipine besylate 5 mg/valsartan
Severe renal impairment, dialysis. Unilateral/ gastrointestinal disturbances, rash, erythema,
160 mg to amlodipine besylate 10 mg/valsartan 320 mg Pregnancy and lactation, hypersensitivity to Potassium supplement. Potassium-sparing
Amlodipine 10 mg and Valsartan 160 Essential hypertension in patients whose blood bilateral renal stenosis, stenosis to a solitary kidney, joint swelling, back pain, arthralgia. Rare:
Exforge ORALLY once daily, with dose titration occurring every amlodipine, valsartan, or any component of the diuretic, potassium containing salt substitutes or
mg Tablet pressure is not adequately controlled by monotherapy after recent kidney transplantation, hepatic Hypersensitivity. Amlodipine: Gastritis, gingival
1 to 2 weeks if necessary. MAX amlodipine besylate 10 product other drugs that may increase potassium level
impairment, biliary obstructive disorders. Aortic or hyperplasia, gynaecomastia, leucopaenia,
mg/valsartan 320 mg
mitral stenosis, obstructive hyperthrophic myalgia, pancreatitis, hepatitis,
cardiomyopathy thrombocytopaenia, vasculitis. Valsartan:
Neutropaenia, increases in creatinine, serum
potassium and BUN
Angina (exacerbation) during initiation of treatment;
with dosage increases; during beta-blocker
withdrawal; taper slowly prior to calcium channel Hypersensitivity to amlodipine, symptomatic
Headache, dizziness, gingival hyperplasia, Cyclosporin, fluconazole, itraconazole,
Amlodipine 10 mg Tablet Norvasc Hypertension 5 mg once daily. Max: 10 mg blocker therapy. Aortic stenosis (reduced myocardial hypotension, persistent dermatologic reactions,
tachycardia, peripheral oedema ketoconazole, vardenafil
oxygenation with drug-induced hypotension), congestive heart failure
congestive heart failure, pregnancy, hepatic
impairment
Nasopharyngitis, flu, headache, oedema,
peripheral oedema, fatigue, flushing, asthenia,
Risk of hypotension in sodium or volume depleted vertigo, tachycardia, palpitations, orthostatic
patient, beta blocker withdrawal should be gradual. hypotension, cough, pharyngolaryngeal pain,
Doses range from amlodipine besylate 5 mg/valsartan
Severe renal impairment, dialysis. Unilateral/ gastointestinal disturbances, rash, erythema,
160 mg to amlodipine besylate 10 mg/valsartan 320 mg Pregnancy and lactation, hypersensitivity to Potassium Supplement. Potassium-sparing
Amlodipine 5 mg and Valsartan 160 Essential hypertension in patients whose blood bilateral renal stenosis, stenosis to a solitary kidney, joint swelling, back pain, arthralgia. Rare:
Exforge ORALLY once daily, with dose titration occurring every amlodipine, valsartan or any component of the diuretic, potassium containing salt substitutes or
mg Tablet pressure is not adequately controlled by monotherapy after recent kidney transplantation, hepatic Hypersensitivity. Amlodipine: Gastritis, gingival
1 to 2 weeks if necessary. MAX amlodipine besylate 10 product other drugs that may increase potassium level
impairment, biliary obstructive disorders. Aortic or hyperplasia, gynaecomastia, leucopaenia,
mg/valsartan 320 mg
mitral stenosis, obstructive hyperthrophic myalgia, pancreatitis, hepatitis,
cardiomyopathy thrombocytopaenia, vasculitis. Valsartan:
Neutropaenia, increases in creatinine, serum
potassium and BUN
Angina (exacerbation) during initiation of treatment;
with dosage increases; during beta-blocker
withdrawal; taper slowly prior to calcium channel Hypersensitivity to amlodipine, symptomatic
Headache, dizziness, gingival hyperplasia, Cyclosporin, fluconazole, itraconazole,
Amlodipine 5 mg Tablet Norvasc Hypertension 5 mg once daily. Max: 10 mg blocker therapy. Aortic stenosis (reduced myocardial hypotension, persistent dermatologic reactions,
tachycardia, peripheral oedema ketoconazole, vardenafil
oxygenation with drug-induced hypotension), congestive heart failure
congestive heart failure, pregnancy, hepatic
impairment
Ammonium Bicarbonate, Tincture If consumed in very large dose can cause
Expect Stimulant Cough 10 - 20 ml 3 times daily Can be irritant to mucous membrane Hepatic or renal impaiment Not known
Ipecac, etc Mixture nausea and vomiting
Apply to affected nail once or sometimes twice a week
after filling and cleansing, allow to dry, treat finger nail Avoid contact with eyes, previous hypersensitivity or
Amorolfine 5 % Nail Lacquer Loceryl Fungal nail infections Slight transient burning sensation Hypersensitivity to amorolfine Not known
for 6 months, toe nail for 9 - 12 months (review at intolerance to other topical antifungal agents
intervals of 3 months)
Hypersensitivity to penicillins, possible cross
Amoxicillin & Clavulanate 228 mg/5 ml Moderate infections: CHILD 7 - 12 year: 10 ml, 2 - 6 Diarrhoea, pseudomembraneous colitis, sensitivity with other β-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin Infections caused by susceptible organisms Renal impairment, severe hepatic dysfunction
Syrup year: 5 ml. Severe infections: 2 - 6 year: 10 ml indigestion, GI upsets, increased liver enzyme penicillin-associated cholestatic jaundice or contraceptives, methotrexate
hepatic dysfunction
Diarrhoea, pseudomembraneous colitis, GI
Infections caused by susceptible organisms. upsets, increased liver enzyme, urticaria and Hypersensitivity to penicillins, possible cross
CHILD less than 3 months: 30mg/kg 12 hourly. 3
Amoxicillin 1 g & Clavulanate 200 mg Respiratory tract, skin, soft tissue, GUT infection, Pregnancy, breast-feeding, renal or liver failure, erythematous multiforme, Steven-Johnson sensitivity with other â-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin months - 12 years: 30mg/kg 6 - 8 hourly. ADULT: 1.2 g
Injection septicaemia, peritonitis, post-operative infection & pseudomembranous colitis syndrome, toxic epidermal necrolysis, exfoliative penicillin-associated cholestatic jaundice or contraceptives, methotrexate
by IV or intermittent infusion 6 - 8 hourly
osteomyelitis dermatitis, transient leucopenia, hepatic dysfunction
thrombocytopenia, haemolytic anaemia
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Infections caused by susceptible strains of gram ADULT: 250 - 500 mg 3 times daily. CHILD: 20 - 40 Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
Amoxicillin 250 mg Capsule Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
positive and gram negative organisms mg/kg/day in divided doses 8 hourly impairment, superinfection rash, hepatitis, cholestatic jaundice
Diarrhoea, indigestion, nausea, vomiting,
candidiasis, rash, pseudomembranous colitis,
Infections due to beta-lactamase producing strain Hypersensitivity to penicillins, possible cross
ADULT & CHILD more than 12 years: Mild to moderate hepatitis, cholestatic jaundice, crystalluria,
Amoxicillin 500 mg & Clavulanate 125 where amoxicillin alone is not appropriate. Respiratory sensitivity with other β-lactams. History of Aminoglycosides, anticoagulants, oral
infections: 625 mg twice daily. Severe infections: 1 g Renal or hepatic impairment, pregnancy erythema multiforme, Stevens-Johnson
mg Tablet tract, skin, soft tissue, GUT infection, septicaemia, penicillin-associated cholestatic jaundice/hepatic contraceptives, methotrexate
twice daily syndrome, toxic epidermal necrolysis, reversible
peritonitis, post-operative infection & osteomyelitis dysfunction
leucopaenia, thrombocytopaenia, haemolytic
anaemia, CNS disturbances
Diarrhoea, pseudomembraneous colitis,
Infections caused by susceptible organisms. gastrointestinal upsets, increased liver enzyme, Hypersensitivity to penicillins, possible cross
CHILD less than 3 months: 30mg/kg 12 hourly. 3
Amoxicillin 500 mg and Clavulanate Respiratory tract, skin, soft tissue, GUT infection, Pregnancy, breast-feeding, renal or liver failure, urticaria and erythematous multiforme, Steven- sensitivity with other beta-lactams. History of Aminoglycosides, anti-coagulants, oral
Augmentin months - 12 years: 30 mg/kg 6 - 8 hourly. ADULT: 1.2 g
100 mg Injection septicaemia, peritonitis, post-operative infection and pseudomembranous colitis Johnson syndrome, toxic epidermal necrolysis, penicillin-associated cholestatic jaundice or contraceptives, methotrexate
by IV or intermittent infusion 6 - 8 hourly
osteomyelitis exfoliative dermatitis, transient leucopenia, hepatic dysfunction
thrombocytopenia, haemolytic anaemia
CHILD less than 10 years: 125 - 250 mg 8 hourly.
Amoxicillin Trihydrate 125 mg/5 ml Infections caused by susceptible strains of gram Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
- CHILD less than 20 kg: 20 - 40 mg/kg/day in 3 - 4 Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
Syrup positive and gram negative organisms impairment, superinfection rash, hepatitis, cholestatic jaundice
divided doses
Nausea and vomiting, anaemia, Cyclosporin, digitalis glycosides, non-
Amphotericin B 0.15% Eye Drops - Fungal infection of the cornea 1 drop hourly or 2 hourly Renal impairment Hypersensitivity to Amphotericin B
thrombocytopenia depolarizing neuromuscular blockers
Nausea and vomiting, anaemia, Cyclosporin, digitalis glycosides, non-
Amphotericin B 0.25% Eye Drops - Fungal infection of the cornea 1 drop hourly or 2 hourly Renal impairment Hypersensitivity to Amphotericin B
thrombocytopenia depolarizing neuromuscular blockers
Fever, headache, anorexia, weight loss, GI
ADULT: 0.25 mg/kg/day by IV infusion, gradually disturbances, malaise, epigastric pain,
Avoid rapid infusion, renal impairment. Hepatic &
increase if tolerated to 1 mg/kg/day. Maximum in dyspepsia, generalized pain, anaemia, abnormal Corticosteroids, nephrotoxic antibiotics and
Amphotericin B 50 mg Injection Fungizone Systemic fungal infections renal function tests, blood count & plasma electrolyte Hypersensitivity
severe cases: 1.5 mg/kg daily or on alternate days. For renal function. Rarely cardiovascular toxicity, antineoplastics
monitoring are required. Pregnancy, lactation
neonates, lower doses are recommended haematologic reactions, neurologic reactions,
liver failure
ADULT: 375 - 750 mg bd. CHILD more than 30 kg- Overgrowth of non-susceptible organism. Check
Ampicillin Sodium & Sulbactam GI disturbances, phlebitis, skin rashes, itching,
Unasyn Susp. Treatment of susceptible bacterial infections adult dose, less than 30 kg: 25 - 50 mg/kg/day in 2 periodically for organ system dysfunction during History of allergic reaction to any penicillins Not known
Sodium 250 mg/5 ml Suspension blood disorders, anaphylaxis and superinfection
divided doses prolong therapy
Overgrowth of non-susceptible organism. Check
Ampicillin Sodium & Sulbactam ADULT & CHILD more than 30 kg: 375 - 750 mg twice GI disturbances, phlebitis, skin rashes, itching,
Unasyn Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins Not known
Sodium 375 mg Tablet daily. Maximum: 3 g daily blood disorders, anaphylaxis and superinfection
prolong therapy
ADULT: 1.5 - 12 g/day in divided doses 6 - 8 hourly.
Maximum: 4 g Sulbactam. CHILD: 150-300 mg/kg/day
Overgrowth of non-susceptible organism. Check
Ampicillin Sodium 1g & Sulbactam 6 - 8 hourly. Prophylaxis of surgical infections: 1.5 - 3 g GI disturbances, phlebitis, skin rashes, itching, Concurrent use with oral contraceptives may
Unasyn 1.5g Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins
Sodium 500mg Injection at induction of anaesthesia. May be repeated 6 - 8 blood disorders, anaphylaxis and superinfection result in decreased contraceptive effectiveness
prolong therapy
hourly. NEONATES: First week of life, 75mg/kg/day in
divided doses every 12 hour
ADULT: 1.5 - 12 g/day in divided doses 6 - 8 hourly.
Overgrowth of non-susceptible organism. Check
Ampicillin Sodium 500 mg & Maximum: 4 g Sulbactam per day. CHILD: 150- GI disturbances, phlebitis, skin rashes, itching, Concurrent use with oral contraceptives may
Unasyn 750 mg Treatment of susceptible bacterial infections periodically for organ system dysfunction during History of allergic reaction to any penicillins
Sulbactam Sodium 250 mg Injection 300mg/kg/day 6 - 8 hourly. Prophylaxis: 1.5 -3 g at blood disorders, anaphylaxis and superinfection result in decreased contraceptive effectiveness
prolong therapy
induction of anaesthesia. May be repeated 6 - 8 hourly
250 - 500 mg IM/IV every 4 - 6 hours. Maximum: 400 Hypersensitivity to cephalosporins. Chronic
GI disturbances, skin rashes, pruritis, urticartia, Excretion impaired by probenecid. Increased risk
Treatment of susceptible bacterial infections (non beta- mg/kg/day. Meningitis: 2 g 6 hourly. CHILD: 150 treatment requires assessment of renal, hepatic&
Ampicillin Sodium 500 mg Injection Penbritin fever, anaphylaxis, blood disorders, Hypersensitivity to penicillins of skin rashes with allopurinol. May decrease
lactamase-producing organisms); meningitis mg/kg/daily IV in divided doses. Usual children dose haematopoietic functions. Renal impairment,
superinfection effectiveness of oral contraceptives and atenolol
less than 10 years, half adult dose lymphatic leukaemia
CHILD: 50 - 100 mg/kg/day 4 times daily. Under 1 year:
Ampicillin Trihydrate 125 mg/5 ml Treatment of susceptible bacterial infections (non beta- Hypersensitivity to cephalosporins. Severe renal Diarrhoea, indigestion, nausea, vomiting,
Penbritin 62.5 - 125 mg 4 times daily, 1 - 10 years: 125 - 250 mg Hypersensitivity to penicillins Bacteriostatic drugs, anticoagulants
Suspension lactamase-producing organisms) dysfunction occasionally rashes
4 times daily
Hyperlipidemia, moderate to severe hepatic
Hot flashes, asthenia, peripheral oedema,
impairment, severe impairment of renal function
Treatment of hormone responsive metastatic or locally vaginal bleeding, deep vein thrombosis, Hypersensitivity to anastrazole, pregnancy. Not
Anastrozole 1 mg Tablet Arimidex 1 mg daily (creatinine clearance less than 20 mL/min). Lowers Oestrogens, tamoxifen
advanced breast cancer after failure of tamoxifen arthralgia, backpain, cough, dypsnea, headache, indicated for premenopausal women
circulating oestrogen levels which may cause a
nausea, rash, hypercholesterolaemia
reduction in bone mineral density
Insufficiently controlled Diabeted Mellitus, recent
Myocardial Infarction, severe organic heart or
vascular disorders, hyperthyroidism, Diarrhoea, hypokalemia, hypomagnesemia,
Ciclosporine; Anidulafungin steady state AUC
phaeochromocytoma, prostatic hypertrophy, bladder- thrombocytopenia, coagulopathy, convulsion,
Treatment of invasive candidiasis, including may be slightly increased. No dosage
neck obstruction, cystic fibrosis, predisposition to headache, increased gamma- Hypersensitivity to anidulofungin or other
Anidulafungin 100mg Injection Eraxis® candidemia in adults when intolerance or resistance to 200 mg single loading dose on day 1, then 100 mg daily adjustment is needed. Antifungal agents:
narrow-angle glaucoma. Pregnancy, lactation. glutamyltransferase, blood alkaline phosphatase, antifungals of echinocandin class eg caspofungin
Amphotericin B or Fluconazole Antifungal agents may diminish the therapeutic
Infusion rate should not exceed 1.1 mg/min. Hepatic aspartate aminotransferase and alanine
effect
dysfunction, significant, worsening hepatic failure, aminotransferase, rash, pruritus
hepatitis/clinically significant hepatic abnormalities
have occurred
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Hypersensitivity to any of the components of


product, dry eyes; especially keratoconjunctivitis
ADULT : Instill 1 drop, 3 - 4 times daily, into the lower sicca, risk of narrow angle glaucoma, receiving
Antazoline HCl, Tetrahydrozoline HCl Hay fever, conjunctivitis, allergic conjunctivitis, vernal Transient irritation may occur immediately after Mild burning sensation, headache, and
Spersallerg eyelid. CHILD 2 - 12 years : Instill 1 drop daily or twice monoamine oxidase inhibitors or within 14 days Not known
and Benzalkonium Cloride Eye Drops keratoconjunctivitis and eczematosa instillation sleepiness, tachycardia, blurred vision
daily of its treatment, children under two years of age;
due to the greater incidence of systemic
absorption and effects
Prevention of Rh(D) sensitisation by IM injection to 50 - 100 mcg within 72 hours after incompatible blood
Anti RhD Gamma Globulin 250 mcg/2 Never administer by IV or to infant. IgA deficiency. Pain at injection site. Slight temperature
Rhogam rhesus-negative woman after delivery of rhesus- transfusion: 25 mcg (125 units) per ml transfused RhD positive mother Live virus vaccines
ml Injection (500 units=100 mcg) Hypersensitivity to thiomersal or human Ig elevation
positive infant blood, up to 1000 mcg
i) To be used when conventional anti-rejection therapy
is not successful ii) Treatment of aplastic anaemia not
responding to oxymethalone after 3 months, in which
Perform test dose, prophylactic platelet transfusion
there is persistent pancytopenia with repeated attacks
10 - 30 mg/kg body weight daily. Slow IV infusion (over before and after infusion. Sodium and fluid overload. Severe and unremitting thrombocytopenia or
Antilymphocyte/Antithymocyte of septicaemia and bleeding. iii) Severe aplastic
Atgam at least 4 hours) diluted in 250 - 500 ml Normal Saline. Monitor for allergic reactions and serum sickness leucopenia, generalized rash, tachycardia, Hypersensitivity, acute viral illness. Live vaccines, increased risk of infection.
Immunoglobulin (from Horse) Injection anaemia with the following parameters: a) Granulocyte
For Graft versus host disease treatment:40 mg/kg/day Monitor for signs of leukopenia, thrombocytopenia or dyspnoea, hypotension, anaphylaxis.
less than 0.5x109/L b) Platelet less than 20x109/L c)
concurrent infection. Perform skin testing
Reticulocyte less than 20x109/L iv) As a conditioning
regime prior to transplant. v) Graft-versus-host disease
treatment
Allergy to neomycin. Prior systemic reaction to Severe febrile infection, acute disease,
Antirabies Immunoglobulin (Human) 20 iu/kg; half by IM and half by infiltration around the Minor local reactions, systemic reactions,
Imogam Rabies Treatment of rabies, post-exposure human immunoglobulin preparation, isolated progressive chronic disease, hypersensitivity to Corticosteroids and immunosuppressant
300 iu/2ml wound hypersensitivity reaction, neuropathy
immunoglobulin A deficiency any of the ingredients of the vaccine
Monitor for allergic reactions, perform test dose,
prophylactic platelet transfusion before and after
i) To be used when conventional anti-rejection therapy
infusion and monitor fluid overload, discontinue
is not successful (patients who do not respond to horse Leucopenia, nausea, vomiting, dizziness,
immediately & permanently withdraw in case of
serum) ii) Treatment of aplastic anaemia not headache, fever, chills hypotension, tachycardia,
Antithymocyte Immunoglobulin (from anaphylactic reaction. Monitor blood cell count for 2
responding to oxymetholone after 3 months, in which Antirejection therapy: 2.5-5 mg/kg/day dyspnoea, pain at infusion site, peripheral Hypersensitivity Live vaccines
rabbit) Injection week after end of therapy. Monitor platelet count in
there is persistent pancytopenia with repeated attacks thrombophlebitis, thrombocytopenia,
patient with initial thrombocytopenia & especially in
of septicaemia and bleeding. iii) Severe aplastic neutropenia, serum sickness
heart transplant patients. Premed with
anaemia. iv) Graft-versus-host disease treatment
corticosteroids & antihistamines may prevent or
alleviate 1st dose syndrome. Pregnancy & lactation
Chest pain, hypotension, chills, nervousness,
cellulitis, bruising, pruritus, rash, urticaria,
anorexia, nausea, coagulation disorder, back Hypersensitivity to any component of the
Reconstitute content for the vial with 5 ml sterile
Antivenene Malaysian Pit Viper Sensitivity testing should be performed before the pain, circumoral paraesthesia, general formulation, unless the benefits outweigh the
- Bitten by pit viper pyrogen-free distilled water. Administer by IV infusion Not known
Injection administration paraesthesia, myalgia, asthma, cough, risks and appropriate management for
200 ml of normal saline over a period of 1 - 2 hours
dyspnoea, sputum increased, wheezing, allergic anaphylaxis is available
reaction, serum sickness, subcutaneous nodule,
wound infection, anaphylaxis, serum sickness
The reconstituted antivenin should be given by slow Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Respiratory support maybe essential. Sensitivity
intravenous infusion, approximately urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
Antivenene Serum (Cobra) Injection - Treatment for cobra bites testing should be performed before the Not known
2ml/min.Subsequent dose can be given every 12 hours shock, transfusion reaction due to serum protein risks and appropriate management for
administration
according to the clinical symptoms reaction ,serum sickness anaphylaxis is available
Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Antivenene Serum (Sea snake) 1000 1000 units by IV infusion over 1/2 to 1 hour. In severe Sensitivity testing should be performed before the urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
- Treatment for sea snake bites Not known
units/26.3 ml Injection cases 3000 -10000 units may be required administration shock, transfusion reaction due to serum protein risks and appropriate management for
reaction ,serum sickness anaphylaxis is available
Recommended initial dose is 20ml by intravenous
infusion. The injection should be given very slowly as 5 Anaphylaxis with hypotension, dyspnea, Hypersensitivity to any component of the
Antivenene Serum Snake polyvalent minutes by direct slow intravenous route or 1hour by Sensitivity testing should be performed before the urticaris, Immune hypersensitivity reaction , formulation, unless the benefits outweigh the
Antidote for snake bites Not known
Injection infusion. If symptoms continue, further doses are administration shock, transfusion reaction due to serum protein risks and appropriate management for
administered as required until symptoms completely reaction ,serum sickness anaphylaxis is available
disappear
Alfuzosin, alprazolam, astemizole,
carbamazepine, cisapride, clarithromycin,
dexamethasone, diltiazem, eletriptan, ethinyl
estradiol, etonogestrel, fentanyl ,ifosfamide,
In combination with other antiemetic agents for Moderate to severe liver impairment, pregnancy. Hiccups, asthenia or fatigue, increased
125 mg 1 hour prior to chemotherapy on Day 1. To be imatinib, irinotecan, iraconazole, ketoconazole,
prevention of delayed nausea and vomiting associated Caution is advised both during and up to 2 weeks ALT/AST, constipation, diarrhea, dyspepsia, Hypersensitivity, breastfeeding, concurrent use
Aprepitant 125 mg Capsule Emend given as part of a 3-day regimen that includes a levonorgestrel, medroxyprogesterone,
with initial and repeat course of highly emetogenic after the end of treatment due to the inhibitory and eructation, headache, dizziness, anorexia, of pimozide, terfenadine, astemizole, cisapride
corticosteroid and a 5-HT3 antagonist methylprednisolone, midazolam, norethindrone,
chemotherapy inductive effects of aprepitant on CYP3A4 substrates Stevens-Johnson syndrome and somnolence
norgestrel, paclitaxel, paroxetine, phenytoin,
rifampin, ritonavir, etrfenadine, tolbutamide,
vinblastine ,vincristine, liposome vinorelbine,
warfarin
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Alfuzosin, alprazolam, astemizole,
carbamazepine, cisapride, clarithromycin,
dexamethasone, diltiazem, eletriptan, ethinyl
Moderate to severe liver impairment, pregnancy. estradiol, etonogestrel, fentanyl ,ifosfamide,
In combination with other antiemetic agents for Hiccups, asthenia or fatigue, increased
80 mg once daily in the morning on Days 2 and Day 3. Caution is advised both during and up to 2 weeks imatinib, irinotecan, iraconazole, ketoconazole,
prevention of delayed nausea and vomitting associated ALT/AST, constipation, diarrhea, dyspepsia, Hypersensitivity, breastfeeding, concurrent use
Aprepitant 80 mg Capsule Emend To be given as part of a 3-day regimen that includes a after the end of treatment due to the inhibitory and levonorgestrel, medroxyprogesterone,
with initial and repeat course of highly emetogenic eructation, headache, dizziness, anorexia, of pimozide, terfenadine, astemizole, cisapride
corticosteroid & a 5-HT3 antagonist inductive effects of aprepitant on CYP3A4 methylprednisolone, midazolam, norethindrone,
chemotherapy Stevens-Johnson syndrome and somnolence
substrates. norgestrel, paclitaxel, paroxetine, phenytoin,
rifampin, ritonavir, etrfenadine, tolbutamide,
vinblastine ,vincristine, liposome vinorelbine,
warfarin
All patients should receive a 1 ml IV test dose at least
10 minutes prior to loading dose. Initially 2 million KIU MI, shock, kidney tubular necrosis, lung Increased effect with heparin. Blocks aktivity of
Only for Open Heart Surgery (extracorporeal Previous exposure to aprotinin (increased risk of
Aprotinin 10,000 KIU/ml Injection Trasylol bolus followed by 2 million KIU in heart-lung machine oedema,atrial fibrillation, hypersensitivity Hypersensitivity to aprotinin products thrombolytic agents and antihypertensive effects
circulation) hypersensitivity),renal insufficiency.
followed by a slow infusion of 500,000 KIU/hr until end reactions, localised thrombophlebitis of ACE inhibitors, succinylcholine
of surgery. CHILD: 20,000 KIU/kg/day
It should not be used before phototherapy or in
Aqueous Cream - Dry skin As a soap or apply to the skin as an emollient cream Not known Not known Not known
phototesting procedures
Suicide, tardive dyskinesia, neuroleptic malignant
Insomnia, restlessness, headache, dizziness,
syndrome, seizure disorder, diabetes mellitus, CV
akathisia, somnolence, sedation, tremor,
disease, cerebrovascular disease, dementia-related
i) Treatment of acute episodes of schizophrenia and for Schizophrenia: 10 or 15 mg/day. Maintenance dose: 15 extrapyramidal disorder, blurred vision,
psychosis and CV adverse events in elderly. May
maintenance of clinical improvement during mg/day. Bipolar mania: Starting dose: 15 or 30 mg/day. tachycardia, orthostatic hypotension, nausea, Patients who are hypersensitive to aripiprazole Enhance effect of antihypertensive agents,
Aripiprazole 10mg Tablet Abilify, AripMT disrupt body's ability to increase/reduce core body
continuation therapy. ii) Treatment of acute manic Dose adjustment should occur at intervals of not less vomiting, constipation, dyspepsia, or to any of the excipients. alcohol, quinidine, ketoconazole, carbamazepine
temperature. Dysphagia, pregnancy & lactation. May
episodes associated with bipolar I disorder than 24 hour asthenia/fatigue, weight gain, anxiety diabetic
impair ability to drive or operate machinery. Safety
ketoacidosis , neuroleptic malignant syndrome,
and efficacy have not been established in children
seizure, peripheral oedema
less than 13 years of age
Suicide, tardive dyskinesia, neuroleptic malignant
Insomnia, restlessness, headache, dizziness,
syndrome, seizure disorder, diabetes mellitus, CV
akathisia, somnolence, sedation, tremor,
disease, cerebrovascular disease, dementia-related
i) Treatment of acute episodes of schizophrenia and for Schizophrenia: 10 or 15 mg/day. Maintenance dose: 15 extrapyramidal disorder, blurred vision,
psychosis and CV adverse events in elderly. May
maintenance of clinical improvement during mg/day. Bipolar mania: Starting dose: 15 or 30 mg/day. tachycardia, orthostatic hypotension, nausea, Patients who are hypersensitive to aripiprazole Enhance effect of antihypertensive agents,
Aripiprazole 15mg Tablet Abilify, AripMT disrupt body's ability to increase/reduce core body
continuation therapy. ii) Treatment of acute manic Dose adjustment should occur at intervals of not less vomiting, constipation, dyspepsia, or to any of the excipients. alcohol, quinidine, ketoconazole, carbamazepine
temperature. Dysphagia, pregnancy & lactation. May
episodes associated with bipolar I disorder than 24 hour asthenia/fatigue, weight gain, anxiety diabetic
impair ability to drive or operate machinery. Safety
ketoacidosis , neuroleptic malignant syndrome,
and efficacy have not been established in children
seizure, peripheral oedema
less than 13 years of age
Hypersensitivity to lumefantrine or halofantrine,
ADULT and CHILD over 12 years weighing over 35 kg :
or artemether or other artemisinin compounds, Droperidol, amiloride, amitriptyline, azithromycin,
4 tablets as a single dose at the time of initial diagnosis,
history of arrhythmias, bradycardia, and chlorpromazine, ciprofloxacin, clomipramine,
again 4 tablets after 8 hours and then 4 tablets twice Abdominal pain, anorexia, diarrhea, vomiting,
Electrolyte disturbances, hepatic impairment, renal congestive heart failure accompanied by erythromycin, fluconazole, frusemide,
Artemether 20mg + Lumefantrine daily (morning and evening) on each of the following nausea, palpitation, cough, headache, dizziness,
Riamet Acute uncomplicated falciparum malaria impairment, concomitant administration of drugs that reduced left ventricular ejection fraction, hydrochlorothiazide, mefloquine, nalidixic acid,
120mg two days (total course comprises 24 tablets). INFANT sleep disturbances, asthenia, arthralgia, myalgia,
prolong QT interval, first trimester of pregnancy congenital QT interval prolongation. Not ofloxacin, procainamide, pyrimethamine,
and CHILD weighing 5 kg to less than 35 kg : A 6 dose cough, asthenia, fatigue, pruritus, rash
recommended in the first trimester of pregnancy quinidine, quinine, spironolactone, sulfadoxine
regimen with 1 to 3 tablets per dose, depending on
or in children below 5 kg, lactation, family history and pyrimethamine
bodyweight
of sudden death
Use cautiously in patients with preexisting kidney Antacids, aspirin, contraceptives combination,
ADULT: 100-250 mg once or twice daily CHILD: 100
stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 100 mg Tablet Vitamin C deficiency mg three times daily for one week followed by 100mg History of hyperoxaluria
haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
daily until symptoms abate.
anaemia and avoid rapid intravenous injections warfarin
Use cautiously in patients with preexisting kidney Antacids, aspirin, contraceptives combination,
ADULT: 100-250 mg once or twice daily CHILD: 100
stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 500 mg Tablet Vitamin C deficiency mg three times daily for one week followed by 100mg History of hyperoxaluria
haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
daily until symptoms abate.
anaemia and avoid rapid intravenous injections warfarin
Use cautiously in patients with preexisting kidney Antacids, aspirin, contraceptives combination,
Therapeutic: Not less than 250 mg daily in divided stone disease, erythrocyte G6PD deficiency, In large doses, gastrointestinal disturbances, cyanocobalamin, deferoxamine, gentamicin,
Ascorbic Acid 500 mg/2 ml Injection For prevention and treatment of scurvy History of hyperoxaluria
doses haemochromatosis, thalassaemia or sideroblastic renal calcium oxalate calculi formation haloperidol, iron, levodopa, methotrexate,
anaemia and avoid rapid intravenous injections warfarin
Avoid abrupt withdrawal; gradual withdrawal over a
period of 1 to 2 weeks is recommended. Hypersensitivity to atenolol products,
Hypertension and arrythmias; 50 - 100 mg daily, Bronchospastic disease, congestive heart failure, Chronic heart failure, AV block, bradycardia, bradycardia, 2nd and 3rd degree AV block overt
Hypertension, angina pectoris, myocardial infarction Clonidine, catecholamine-depleting agents, beta-
Atenolol 100 mg Tablet Tenormin Angina; 100 mg daily, Myocardial infarction; diabetes mellitus, hyperthyroidism/thyrotoxicosis. bronchospasm, dizziness, vertigo, nausea, cardiac failure, cardiogenic shock, metabolic
and arrhythmias blockers
individualised Patients receiving clonidine - discontinue atenolol fatigue, diarrhoea acidosis, severe peripheral circulatory
several days prior to withdrawal of clonidine. disturbances, sick sinus syndrome
Peripheral vascular and renal disease
Avoid abrupt withdrawal; gradual withdrawal over a
period of 1 to 2 weeks is recommended. Hypersensitivity to atenolol products,
Hypertension and arrythmias; 50 - 100 mg daily, Bronchospastic disease, congestive heart failure, Chronic heart failure, AV block, bradycardia, bradycardia, 2nd and 3rd degree AV block overt
Hypertension, angina pectoris, myocardial infarction Clonidine, catecholamine-depleting agents, beta-
Atenolol 50 mg Tablet Tenormin Angina; 100 mg daily, Myocardial infarction; diabetes mellitus, hyperthyroidism/thyrotoxicosis. bronchospasm, dizziness, vertigo, nausea, cardiac failure, cardiogenic shock, metabolic
and arrhythmias blockers
individualised Patients receiving clonidine - discontinue atenolol fatigue, diarrhoea acidosis, severe peripheral circulatory
several days prior to withdrawal of clonidine. disturbances, sick sinus syndrome
Peripheral vascular and renal disease
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Gastrointestinal disorder or cardiovascular


Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease. Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 10 mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought

Gastrointestinal disorder or cardiovascular


Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 18 mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought

Gastrointestinal disorder or cardiovascular


Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease. Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 25 mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought

Gastrointestinal disorder or cardiovascular


Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 40 mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought

Gastrointestinal disorder or cardiovascular


Hypotension, cardiovascular or cerebrovascular
CHILD and ADOLESCENTS up to 70 kg: Initially 0.5 disorders, weight loss, decreased appetite,
Attention deficit hyperactivity disorder (ADHD) in disease. Hypertension tachycardia. Urinary retention
mg/kg/day for at least 7 days, then increased according weight loss. Nervous system disorders such as
children 6 years and older who do not respond to or bladder dysfunction. Monitor growth in children, MAOIs, CYP2D6 inhibitors (fluoxetine,
to response. Maintenance: 1.2 mg/kg/day. ADULTS dizziness, headache, insomnia, somnolence, Concomitant use with MAOIs. Narrow-angle
Atomoxetine HCl 60mg Capsule Strattera methylphenidate or who have intolerable effects or QT interval prolongation, history of seizures, paroxetine), salbutamol, pressor agents, drugs
and ADOLESCENTS more than 70 kg: Initially 40 mood swings, urinary retention, dysmenorrhea, glaucoma, liver injury, jaundice
have tics. Diagnosis should be made according to DSM susceptibility to angle-closure glaucoma, hepatic that affect noradrenaline
mg/day for at least 7 days then increased according to ejaculation disorder. Orthostatic hypotension and
IV criteria or the guidelines in ICD-10 impairment, suicidal ideation. Pregnancy and
response. Maintenance: 80 mg/day. Max 100 mg/ day syncope, psychiatric disorders such as irritability,
lactation
suicidal thought
Heavy alcohol use, history of liver disease.
Risk of myopathy increased with concurrent
Discontinue therapy if serum transaminase levels
Gastrointestinal disturbances, headache, administration of cyclosporin, fibric acid
rise to 3 times upper limit of normal and are
myalgia, asthenia, insomnia, angioneurotic derivatives, erythromycin, niacin or azole
Hypercholesterolaemia and coronary heart disease persistent. This class of drug has been known to Liver disease, hypersensitivity to atorvastatin,
Atorvastatin 20 mg Tablet Lipitor 10 mg once daily. Maximum: 80 mg daily oedema, muscle cramps, myostitis, myopathy, antifungals. Decreased atorvastatin plasma
intolerant or not responsive to other forms of therapy cause myopathy and renal failure due to pregnancy or lactation
cholestatic jaundice, peripheral neuropathy, concentration with oral antacid suspensions
rhabdomyolysis. Concomitant administration of
pruritus containing magnesium and aluminium
fibrates, niacin, cyclosporin or erythromycin may
hydroxides and colestipol
increase the risk of myopathy
Heavy alcohol use, history of liver disease.
Risk of myopathy increased with concurrent
Discontinue therapy if serum transaminase levels
Gastrointestinal disturbances, headache, administration of cyclosporin, fibric acid
rise to 3 times upper limit of normal and are
myalgia, asthenia, insomnia, angioneurotic derivatives, erythromycin, niacin or azole
Hypercholesterolaemia and coronary heart disease persistent. This class of drug has been known to Liver disease, hypersensitivity to atorvastatin,
Atorvastatin 40 mg Tablet Lipitor 10 mg once daily. Maximum: 80 mg daily oedema, muscle cramps, myostitis, myopathy, antifungals. Decreased atorvastatin plasma
intolerant or not responsive to other forms of therapy cause myopathy and renal failure due to pregnancy or lactation
cholestatic jaundice, peripheral neuropathy, concentration with oral antacid suspensions
rhabdomyolysis. Concomitant administration of
pruritus containing magnesium and aluminium
fibrates, niacin, cyclosporin or erythromycin may
hydroxides and colestipol
increase the risk of myopathy
Heavy alcohol use, history of liver disease.
Risk of myopathy increased with concurrent
Discontinue therapy if serum transaminase levels
Gastrointestinal disturbances, headache, administration of cyclosporin, fibric acid
rise to 3 times upper limit of normal and are
myalgia, asthenia, insomnia, angioneurotic derivatives, erythromycin, niacin or azole
Hypercholesterolaemia and coronary heart disease persistent. This class of drug has been known to Liver disease, hypersensitivity to atorvastatin,
Atorvastatin 80 mg Tablet Lipitor 10 mg once daily. Maximum: 80 mg daily oedema, muscle cramps, myostitis, myopathy, antifungals. Decreased atorvastatin plasma
intolerant or not responsive to other forms of therapy cause myopathy and renal failure due to pregnancy or lactation
cholestatic jaundice, peripheral neuropathy, concentration with oral antacid suspensions
rhabdomyolysis. Concomitant administration of
pruritus containing magnesium and aluminium
fibrates, niacin, cyclosporin or erythromycin may
hydroxides and colestipol
increase the risk of myopathy
ADULT and CHILD more than 1 month: Initially 300 - Tachycardia, flushing, skin and allergic
Other neuromuscular disease, severe Effect enhanced by inhalation anaesthesia,
Atracurium Besylate 25 mg/2.5 ml 600 mcg/kg IV injection. Subsequent doses of 80 - 200 reactions.Transient hypotension attributed to
Tracrium Muscle relaxation cardiovascular disease, myasthenia gravis & severe Not known aminoglycoside, polymyxins, lithium, magnesium
Injection mcg/kg may be given as necessary. IV infusion: 5 - 10 histamine release. Rarely, bronchospasm,
electrolyte disorders salts, procainamide and quinidine
mcg/kg/minute (300 - 600 mcg/kg/hour) anaphylactoid reactions
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
ADULT and CHILD more than 1 month: Initially 300 - Tachycardia, flushing, skin and allergic
Other neuromuscular disease, severe Effect enhanced by inhalation anaesthesia,
Atracurium Besylate 50 mg/5 ml 600 mcg/kg IV injection. Subsequent doses of 80 - 200 reactions.Transient hypotension attributed to
Tracrium Muscle relaxation cardiovascular disease, myasthenia gravis & severe Not known aminoglycoside, polymyxins, lithium, magnesium
Injection mcg/kg may be given as necessary. IV infusion: 5 - 10 histamine release. Rarely, bronchospasm,
electrolyte disorders salts, procainamide and quinidine
mcg/kg/minute (300 - 600 mcg/kg/hour) anaphylactoid reactions
Atropine Sulphate 0.3%, Cocaine HCl
Subconjunctival injection to dilate pupils resistant to Prolonged use may produce local irritation, dry Glaucoma or suspected glaucoma.
1.7%, Adrenaline Acid Tartrate 0.03% - 1 - 2 drops Elderly, infant, children Not known
topical mydriatics throat and eczema of eyelids Hypersensitivity
Mydriatic Injection
PREOPERATIVE MYDRIASIS : one drop of a 1%
Determination of refraction, strabismus, iritis and solution supplemented with one drop of 2.5 or 10% Transient stinging and raised intra-ocular
Risk of systemic effects with the eye drops in infants Glaucoma or suspected glaucoma.
Atropine Sulphate 1% Eye Drops - iridocyclitis, after extra or intracapsular extraction of phenylephrine prior to surgery. ANTERIOR UVEITIS or pressure, local irritation, hyperaemia, oedema Not known
under 3 months-eye ointment preferred Hypersensitivity
lens POSTOPERATIVE MYDRIASIS : one drop of a 1% or and conjunctivitis
2% solution up to 3 times a day
paediatric and geriatric patients, debilitated patients
Loss of cisapride efficacy, procainamide
i) ADULT 300-600 mcg IM/SC 30-60 minutes before with lung disease, autonomic neuropathy, hepatic or
coadministered with atropine may result in
anaesthesia or 300-600 mcg IV immediately before renal disease, may cause heat prostration, patients
Constipation, transient bradycardia (followed by Hypersensitivity to atropine or anticholinergics, additive antivagal effects on atrioventricular
i) Reduce vagal inhibition,salivary and bronchiol induction of anaesthesia ii) ADULT 0.5-1 mg repeated, with ileostomy or colostomy, diarrhoea may indicate
tachycardia, palpitations & arrhythmias), reduced narrow-angle glaucoma, reflux oesophagitis, nodal conduction Major interaction with
secretion in anaesthesia ii) Reversal of excessive every 3-5 minutes. Max Dosage: 0.04 mg/kg body incomplete intestinal obstruction, avoid driving or
bronchial secretions, urinary urgency & retention, obstructive gastrointestinal disease/uropathy, potassium, topiramate, effect of atropine and
Atropine Sulphate 1mg/ml Injection - bradycardia iii) Reversal of effect of competitive muscle weight iii) ADULT 0.6-1.2 mg before or with hazardous activities, may cause neuromuscular
dilatation of the pupils with loss of ulcerative colitis or toxic megacolon, unstable other antimuscuranic may be enahnced by
relaxants iv) Overdosage with other compounds having anticholinesterase iv) ADULT 0.5-1 mg IV/SC, repeated blockade resulting in weakness or paralysis,
accommodation, photophobia, dry mouth, cardiovascular status in acute haemorrhage or concomitant administration of drug with
muscarinic action v) Organophosphate poisoning every 2 hour v) ADULT 2 mg IV/IM, every 30 minutes hyperthyroidism, coronary heart disease, acute
flushing & dryness of the skin thyrotoxicosis antimuscuranic properties. MAOIs may enhance
according to clinical response. Cholinesterase myocardial ischemia, CHF, tachyarrhythmia,
atropine effect. Reduce GIT motality may affect
reactivator should be given at the earliest possible time tachycardia, HTN, or prostatic hypertrophy,
other oral drug absorption
pregnancy, neonates
Chronic immunosuppression , increases risk of
Gastrointestinal disturbances,
neoplasm, hematologic toxicity, mutagenicity.
myelosuppression, pancreatitis, fever.
Bleeding or bruising or signs of infection, bone ACEI, Angiotensin II Antagonist, warfarin,
Opportunistic infections especially in transplant
marrow suppression. Monitor FBC weekly during Hypersensitivity, pregnancy, previous alkylating allopurinol, live vaccines, antibacterial. Reduces
patients receiving concomitant other
Azathioprine 50 mg Tablet Imuran i)Acute leukaemia ii)Immunosuppressive agent i) 1-4 mg/kg/day ii) 1.5-2 mg/kg/day first 8 week of therapy especially with high dose or agents such as cyclophosphamide, the neuromuscular blockade of curare,
immunosuppressants. Bone marrow depression,
severe renal/hepatic impairment. Inherited deficiency chlorambucil, melphalan (risk of neoplasms) tubocurarine but potentiates that of
leucopenia, thrombocytopenia, nausea.
of thiopurine methyltransferase enzyme. Avoid succinylcholine
Uncommonly, anaemia, hypersensitivity
excessive sun/UV exposure. Pregnancy, lactation
reactions, cholestasis, pancreatitis
and elderly
Avoid contact with eyes. May cause
Apply twice daily. Treatment should not exceed 6 Occasionally, local skin irritation, pruritus, tingling Hypersensitivity to propylene glycol and azelaic
Azelaic Acid 20% Cream Skinoren Acne vulgaris hypopigmentation. Should not use with occlusive Not known
months feeling, burning or stinging acid products
dressings or wrappings
Nausea, abdominal discomfort, vomiting,
CHILD 36 - 45 kg: 400 mg, 26 - 35 kg: 300mg, 15 - 25 Antacids. Ergot derivatives. Monitor patients on
flatulence, diarrhoea & loose stools. Hearing
Treatment of complicated respiratory tract infections kg 200 mg, less than 15 kg: 10 mg/kg. To be taken Moderate or severe renal impairment; severe liver Known hypersensitivity to azithromycin or any of concurrent warfarin, digoxin or cyclosporin.
Azithromycin 200 mg/5 ml Granules Zithromax impairment, interstitial nephritis, acute renal
not responding to standard macrolides daily for 3 days or to be taken as a single dose on day impairment; pregnancy & lactation the macrolides Increase levels of tacrolimus, phenytoin,
failure, abnormal liver function, dizziness/vertigo,
1, then half the daily dose on days 2 - 5 bromocriptine, disopyramide
convulsions, headache, somnolence
i) Treatment of complicated respiratory tract infection
Nausea, abdominal discomfort, vomiting,
not responding to standard macrolides ii) Adult
flatulence, diarrhoea & loose stools. Hearing
treatment of uncomplicated genital infections due to i) 500 mg daily for 3 days ii) 1 g as a single dose iii) 1 g Moderate or severe renal impairment, liver Known hypersensitivity to azithromycin or any of Antacids, ergot derivatives. Monitor patients on
Azithromycin 250 mg Tablet Zithromax impairment, interstitial nephritis, acute renal
Chlamydia trichomatis or susceptible Neisseria weekly impairment, pregnancy & lactation the macrolides concurrent warfarin, digoxin or cIclosporin
failure, abnormal liver function, dizziness &
gonorrhoea iii) Prophylaxis against Mycobacterium
vertigo, convulsions, headache, somnolence
avium complex in patients with advanced HIV
Nausea, abdominal discomfort, vomiting,
Antacids, ergot derivatives. Monitor patients on
500 mg IV as a single daily dose for a minimum of two flatulence, diarrhoea& loose stools. Hearing
Moderate or severe renal impairment, sever liver Known hypersensitivity to azithromycin or any of concurrent warfarin, digoxin or ciclosporin.
Azithromycin 500 mg Injection Zithromax Only for treatment of severe atypical pneumonia days followed by 500 mg oral dose as a single daily impairment, interstitial nephritis, acute renal
impairment, pregnancy & lactation the macrolides Increase levels of tacrolimus, phenytoin,
dose to complete a 7 - 10 days course failure, abnormal liver function, dizziness&
bromocriptine, disopyramide
vertigo, convulsions, headache, somnolence
ADULT: 400 mg twice daily. Severe infection: 800 mg
Infections caused by ampicillin-sensitive gram Hypersensitivity to cephalosporins, renal or hepatic Diarrhoea, indigestion, urticarial or erythematous
Bacampicillin 400 mg Tablet Penglobe twice daily. CHILD more than 25 kg: 12.5 - 25 mg/kg 12 Hypersensitivity to penicillins Aminoglycosides, oral contraceptives
positive& gram negative microorganisms impairment, superinfection rash, hepatitis, cholestatic jaundice
hourly
Pregnancy, patients suffering not only from spasticity Tricyclics and lithium enhance muscle relaxant
Daytime sedation, drowsiness, nausea and other
but also from psychotic disorders, schizophrenia or effect, ACE inhibitor, diuretics and
ADULT: 5 mg 3 times daily. Max: 80 mg daily. CHILD: central nervous system disorders, Epilepsy and other convulsive conditions, corticol
confusional states, epilepsy, cerebrovascular or antihypertensives enhance hypotensive effect.
Baclofen 10 mg Tablet Lioresal Spasticity of the skeletal muscle 0.75 - 2 mg/kg daily (more than 10 years, maximum: gastrointestinal disturbances, dysuria, frequency or subcorticol brain damage, peptic ulceration,
respiratory insufficiency. Central nervous system Sedative effect enhanced with alcohol,
2.5 mg/kg daily) of micturition, enuresis or retention of urine, known hypersensitivity to baclofen
depressants, antihypertensives, levodopa. Caution anxiolytics and hypnotics. Excretion reduced by
respiratory depression
in road users. Avoid abrupt discontinuation ibuprofen and possibly other NSAIDs
For local use only. The use of additives with this Hypersensitivity to any of the components of
Balanced Salt Solution Ocusol For irrigation during ocular surgery Irrigate as directed Ocular irritation Not known
solution may cause corneal decompensation product
Balanced Salt Solution PLUS (fortified For irrigation during intraocular surgery especially in It does not contain a preservative; therefore, do not
Hypersensitivity to any of the components of
with sodium bicarbonate, glucose & B.S.S PLUS patients with poor cornea endothelium and poorly Irrigate as directed reuse for more than one patient. Tissue damage Ocular irritation Not known
product
glutathione) controlled diabetes could result if other drugs are added to the product
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Intestinal obstruction, pyloric stenosis or lesions


which may predispose to obstruction, conditions Hypersensitivity reactions, constipation,
which may predispose to perforation such as acute aspiration pneumonia if aspirated, ventricular
Gastrointestinal perforation, acute bleeding from
ulcerative colitis and acute diverticulitis. Adequate fibrillation, bradycardia, asystole,
i) Up to 150 ml of a 50% - 200% suspension orally ii) gastrointestinal tract, peritonitis, pneumatosis
For x-ray examination of the alimentary tract: i) hydration should be ensured after the procedure to electrocardiographic changes, and hypotension,
Barium Sulphate Suspension Baritop, Barytgen Up to 300 ml of a 30% - 200% suspension orally iii) Up intestinalis, gross intestinal obstruction, known or Not known
Oesophagus ii) Stomach and duodenum iii) Colon prevent severe constipation, history of bronchial urticaria, pruritus, erythema and generalized
to 2 litre of a 30% - 200% suspension orally suspected perforation, hypersensitivity to
asthma or allergy, previous reaction to a contrast rashes, dysphagia, constipation, diarrhea, acute
anything in the barium sulfate suspension
agent, hypertension, advanced cardiac disease, pritonitis, anaphylactic reactions, headache,
intussusception with symptoms of more than 24 dyspnea
hours duration, tracheoesophageal fistula
Constipation, UTI pain, nausea, peripheral
oedema, hypertension, anaemia, surgical wound
complication, weight gain, increased serum
ADULT & CHILD 2 years and above & 35 kg or creatinine, hypophosphataemia diarrhoea, upper
more:20 mg /dose. 2 years or more but less than Pregnancy, avoid breast-feeding for 4 months after respiratory tract infection, hypertrichosis, rhinitis, Immunosuppressives other than ciclosporin and
Prophylaxis of acute organ rejection in de novo renal Known hypersensitivity to basiliximab and
Basiliximab 20 mg Injection Simulect 35kg:10 mg/dose. First dose given within 2 hours the last dose. Re-exposure to a subsequent course fever, viral infection, sepsis, atrial fibrillation; corticosteroids may increase the potential for
transplantation. murine proteins
before start of transplantation and second dose 4th day of therapy of basiliximab headache, insomnia, hypokalaemia, over-immunosuppression
after transplant hyperglycaemia, hyperuricaemia,
hypophosphataemia, hypercholesterolaemia,
tremor, dyspnoea, infection. Hypersensitivity and
anaphylactoid-type reactions
Asthmatic patients, Immunogenic material can result
in astmatic attacks or anaphylaxis. The person
preparing the product should wear gloves, mask and
Hypersensitivity to BCG vaccine. Patients with
gown. Discarded containers, syringes and other Flu-like symptoms, chemical cystitis, urinary tract
positive tuberculin tests, AIDS, burns, on Concurrent use with antimicrobial therapy and
equipment used for handling the vaccine should be infection, nausea, vomiting, anorexia, hematuria,
81 mg intravesically once weekly for 6 weeks, followed immunosuppressive therapy or with immunosuppressive agents may impair efficacy
sterilised before disposal. BCG (intravesical) should urinary frequency, dysuria, local irritative
BCG 81 mg/3 ml Immucyst Superficial bladder cancer by treatments at 3, 6, 12, 18, and 24 months after initial compromised immune systems, who had a of BCG, Drug combinations containing bone
not be administered if there is indication that symptoms, diarrhea; anemia, leukopenia,
treatment transurethral resection or traumatic bladder marrow depressants &/or immunosuppressants
catherisation has been traumatic. BCG should not be prostatitis, ureteral obstruction, systemic BCG
catheterization in the previous week. Active TB, &/or radiation may impair the response
administered earlier than 7 days following infection
evidence of systemic BCG reaction, fever, UTI
transurethral resection. Urine voided in the first 6
hours following intravesical BCG instillation should
be handled as infection waste.
Congenital or acquired cell-mediated immune
deficiencies (including HIV), patients with
0.1 ml by intradermal injection. INFANT under 12 Superficial, self healing ulceration, injection site systemic corticosteroid/ immunosuppressive
BCG Vaccine Freeze-Dried Injection - For the prevention of tuberculosis Children born to HIV positive mothers, pregnancy Not known
months: 0.05 ml reaction, lymphadenopathy treatment, malignant condition, pyrexia,
generalised infected dermatoses, organ
abnormalities
Pulmonary tuberculosis, pregnancy. Adrenal Candidiasis of the mouth and throat, hoarseness
Hypersensitivity to beclomethasone
insufficiency (when replacing systemic corticosteroid or throat irritation, headache, secondary
ADULT : 100 mcg 3 - 4 times daily or 200 mcg twice dipropionate, acute asthma exacerbations,
Beclomethasone Dipropionate 100 Prophylaxis of asthma especially if not fully controlled therapy), exposure to viral infection (chickenpox, hypocortisolism, osteoporosis, cataract,
Becotide daily. CHILD more than 6 years : 50 - 100 mcg 2 - 4 status asthmaticus. Special care is necessary in Not known
mcg/dose Inhalation by bronchodilators measles), ocular herpes simplex, tuberculosis glaucoma, paradoxical bronchospasm
times daily patients with active or quiescent pulmonary
(active or quiescent), untreated fungal, bacterial, or (discontinue immediately). Patients are advised
tuberculosis
systemic viral infections to gargle after using the medication

Pulmonary tuberculosis, pregnancy. Adrenal Candidiasis of the mouth and throat, hoarseness
Hypersensitivity to beclomethasone
insufficiency (when replacing systemic corticosteroid or throat irritation, headache, secondary
dipropionate, acute asthma exacerbations,
Beclomethasone Dipropionate 200 Prophylaxis of asthma especially if not fully controlled ADULT : 1 - 2 puff twice daily. May increase to 2 puff 2 - therapy), exposure to viral infection (chickenpox, hypocortisolism, osteoporosis, cataract,
Beclomet status asthmaticus. Special care is necessary in Not known
mcg/dose Inhalation by bronchodilators 4 times daily measles), ocular herpes simplex, tuberculosis glaucoma, paradoxical bronchospasm
patients with active or quiescent pulmonary
(active or quiescent), untreated fungal, bacterial, or (discontinue immediately). Patients are advised
tuberculosis
systemic viral infections to gargle after using the medication

Nasal irritation, sneezing, epistaxis, rhinorrhea,


ADULT and CHILD over 6 years : Apply 100 mcg (2
watery eyes, nasopharyngeal candidiasis, nasal After nasal surgery or if having untreated nasal
sprays) into each nostril twice daily or 50 mcg (1 spray)
Beclomethasone Dipropionate 50 Prophylaxis and treatment of perennial and seasonal Tuberculosis, first trimester of pregnancy, local or septal perforation, dryness and irritation of the infection, acute asthma exacerbations,
Beconase into each nostril 3 - 4 times/day. Maximum 400 mcg Effects enhanced by nasal vasoconstrictors
mcg/dose Nasal Spray allergic rhinitis and vasomotor rhinitis systemic infection, hypercorticism nose and throat, hoarseness, unpleasant taste hypersensitivity to beclomethasone, status
daily (8 sprays). When symptoms controlled, reduce
and smell, glaucoma, rashes, urticaria, pruritis, asthmaticus
dose to 50 mcg (1 spray) into each nostril twice daily
erythema, cataract, glaucoma
Wash and dry baby's bottom. Apply by spreading the
Benzalkonium 0.01% Cream Drapolene Prevention and treatment of nappy rash cream evenly paying particular attention to the fold of Avoid contact with the eyes, mouth and nose Dermatitis Hypersensitivity to benzalkonium products Not known
the skin, after every nappy change
Benzalkonium Chloride Disinfectant Low level disinfectant suitable for general cleaning and Cleaning purposes: Dilute 1 in 10. Disinfection, use Protect surrounding skin, face and eye. Advice to
Viraclean Skin and eye irritation Hypersensitivity to any of its component Do not mix with other chemicals
Solution disinfection of hard surface undiluted wear personal protective equipment (PPE)
Allergic reactions, glossitis, stomatitis, Hypersensitivity to penicillins& cephalosporins.
i) Treatment of mild to moderately severe infections Diabetes. Not for SC, IV or intralumbarly or into body haemolytic anaemia, leucopenia, Severe pneumonia, empyema, sepsis, Bacteriostatic antibiotics, anti-inflammatory,
Benzathine Penicillin 2.4 mega units i) ADULT: 1.2 mega units IM ii) For syphillis: 2.4 mega
Penadur L.A. due to Penicillin G-sensitive organisms ii) Treatment of cavities. Impaired renal function, infants, elderly, thrombocytopenia, agranulocytosis, neuropathy, pericarditis, meningitis, peritonitis or arthritis antirheumatics, antipyretics, probenecids, oral
Injection (1.8 g) units weekly for 1 - 3 weeks
syphillis hypersensitivity to cephalosporins nephropathy, Jarisch-Herxheimer reactions requiring high dose of penicillin levels, bronchial contraceptives
secondary to bacteriolysis asthma
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Autonomic neuropathy, heart disease, hepatic or
renal disease, hyperthyroidism, paediatric, elderly, Children under 3 years, narrow-angle glaucoma,
Severe mental disturbances, confusion,
potential for abuse, prostatic hypertrophy, glaucoma, closed-angle glaucoma, tardive dyskinesias,
ADULT: Initially 1 mg daily. Maintenance: 5 - 15 mg drowsiness, restlessness, hallucinations, Alcohol and central nervous system depressants
i) Parkinson's disease ii) Drug induced parkinsonism iii) obstructive disease of gastrointestinal or prostatic enlargement, paralytic ileus, chronic
Benzhexol 2 mg Tablet Artane daily in 3 - 4 divided doses. CHILD: 0.02 mg/kg/dose 8 excitement, nausea and vomiting, dry mouth, may increase the sedative effect of benzhexol.
Dystonias genitourinary, pregnancy and lactation. Use with pulmonary disease, sick sinus syndrome,
hourly, gradually increasing to 0.1 - 0.3 mg/kg/dose blurring of vision, constipation, urinary retention, Delayed absorption of other oral drugs
caution in patients with ileostomy or colostomy. thyrotoxicosis, cardiac failure with tachycardia,
glaucoma
Avoid driving or hazardous activities. Monitor lactation
intraocular pressure
Benzoic Acid Compound Half Contact with the eyes, mouth and other mucous Hypersensitivity to any component. Diabetes,
Whitfields Tinea infections of the skin Apply sparingly to affected area once or twice daily Local irritation Not known
Strength (Paed) Ointment membranes should be avoided impaired circulation
Contact with the eyes, mouth and other mucous Hypersensitivity, use in children less than 2
Benzoic Acid Compound Ointment Whitfields Tinea infections of thickened skin of palms and soles Apply sparingly to affected area once or twice daily Local irritation Not known
membranes should be avoided years, diabetes impaired circulation
Apply undiluted to the skin 1 or 2 times daily. Duration
Infected skin, lesions, cuts, abrasions, wounds and
Benzoin Compound Tincture of therapy, may be weeks to months depending on the May result in mild irritation at the site of application Allergic reaction and dermatologic effects Hypersensitivity to any of its compound Not known
burns
infection being treated
Avoid contact with eyes, mouth and other mucous
Benzoyl Peroxide 10% Gel Panoxyl Mild to moderate acne vulgaris Apply sparingly once or twice daily membranes. May bleach dyed clothing and fabrics. Burning or stinging contact dermatitis, redness Hypersensitivity to benzoyl peroxide products Not known
Avoid unnecessary sun exposure
Avoid contact with eyes, mouth and other mucous
Benzoyl Peroxide 5% Gel Panoxyl Mild to moderate acne vulgaris Apply sparingly once or twice daily membranes. May bleach dyed clothing and fabrics. Burning or stinging contact dermatitis, redness Hypersensitivity to benzoyl peroxide products Not known
Avoid unnecessary sun exposure
Prostatic hypertrophy, mental disorder, pregnancy,
ADULT: 0.5 - 1 mg daily usually at bedtimes. Dry mouth, blurred vision, nausea and vomiting,
elderly, tachycardia, obstructive uropathy, Narrow angle glaucoma, tardive dyskinesia,
i) Parkinson's disease ii) Drug induced parkinsonism iii) Maintenance: 1 - 4 mg daily in single or divided doses. constipation, allergic reaction, confusion, drug- Phenothiazine, tricyclic antidepresant and
Benztropine Mesilate 2 mg Tablet Cogentin predisposition to glaucoma, untreated narrow angle children below 3 years old, hypersensitivity to
Dystonias Maximum 6 mg daily. CHILD: 0.02 - 0.06 mg/kg/dose 1 - induced psychosis, heat stroke, hyperpyrexia, anticholinergic
glaucoma, tardive dyskinesia. Avoid driving or benztropine or any component
2 times a day paralytic ileus, raised intraocular pressure
hazardous activities
Used as a 30 seconds gargle or rinse, undiluted. Hepatic or renal impairment, pregnancy, children
ADULT 15 ml. CHILD less 12 years 5-15 ml. less than 6 years, in bacterial infection, appropriate Oral numbness, dryness or thirst, tingling, warm Known hypersensitivity to the drug or to any of
Benzydamine HCl 0.15% Solution Difflam For relief of painful condition of the oral cavity Not known
Uninterrupted treatment should not be more than 7 antibacterial therapy should be used in addition to feeling in mouth, altered sense of taste the components of the vehicle
days product
May be irritant to the skin of some patients,
After bath, apply over the whole body, neck down and burning sensation especially on genitalia and
Contact with mucous membranes, head, face,
leave on for 24 hours then wash off. Reapply for excoriations occasionally rashes, stinging and
Benzyl Benzoate 12.5 % Emulsion broken or inflammed skin, avoid contact with eyes.
- Scabies and pediculosis, for child under 2 years another 24 hours, the first repeat application should be contact dermatitis, local irritation, particularly in Hypersensitivity to benzyl benzoate Not known
(Child) Not recommended for children, lactation (withhold
within 5 days of the initial application, a third application children, splash contact with benzyl benzoate
during treatment)
may be required in some cases may produce irritation to the eyes and mucous
membranes
May be irritant to the skin of some patients,
After bath, apply over the whole body, neck down and burning sensation especially on genitalia and
Contact with mucous membranes, head, face,
leave on for 24 hours then wash off. Reapply for excoriations occasionally rashes, stinging and
Benzyl Benzoate 25 % Emulsion broken or inflammed skin, avoid contact with eyes.
- Scabies and pediculosis another 24 hours, the first repeat application should be contact dermatitis, local irritation, particularly in Hypersensitivity to benzyl benzoate Not known
(Adult) Not recommended for children, lactation (withhold
within 5 days of the initial application, a third application children, splash contact with benzyl benzoate
during treatment)
may be required in some cases may produce irritation to the eyes and mucous
membranes
Hypersensitivity reactions, GI disturbances,
i) ADULT: 600 - 1200 mg IM 4 times daily, increased if
eosinophilia, haemolytic anaemia, leucopenia,
necessary in more serious infections. CHILD: 50 - 100 History of anaphylaxis, accelerated (e.g. hives) or History of anaphylaxis, accelerated (e.g. hives) Bacteriostatic antibiotics, anti-inflammatory,
Benzylpenicillin 1 mega unit (600 mg) i) Infections caused by susceptible organisms ii) agranulocytosis. Convulsions in the presence of
- mg/kg body weight daily IV in 2 - 4 divided doses ii) serum sickness reaction to previous penicillin or serum sickness reaction to previous penicillin antirheumatics, antipyretics, probenecids, oral
Injection Infective endocarditis severely reduced renal function, epilepsy,
ADULT: 7.2 g daily by slow IV infusion in 6 divided administration administration contraceptives
meningitis or cerebral oedema or during
doses
cardiopulmonary bypass procedure
Patients with a history of penicillin or cephalosporin
History of anaphylaxis, accelerated (e.g. hives)
Benzylpenicillin 10,000 units/ml Eye 1-2 drops every 15 minutes or accordingly to needs of hypersensitivity reactions, atopic predisposition (e.g.
- Eye infection Skin rashes, anaphylaxis, urticaria or serum sickness reaction to previous penicillin Not known
Drops the patient asthma), impaired renal function, or pre-existing
administration
seizure disorder
Patients with a history of penicillin or cephalosporin
History of anaphylaxis, accelerated (e.g. hives)
Benzylpenicillin 2,500 units/ml (1.5 1-2 drops every 15 minutes or accordingly to needs of hypersensitivity reactions, atopic predisposition (e.g.
- Eye infection Skin rashes, anaphylaxis, urticaria or serum sickness reaction to previous penicillin Not known
mg/ml) Eye Drops the patient asthma), impaired renal function, or pre-existing
administration
seizure disorder
Hypersensitivity reactions, GI disturbances,
i) ADULT: 600 - 1200 mg IM 4 times daily, increased if
eosinophilia, haemolytic anaemia, leucopenia,
necessary in more serious infections. CHILD: 50 - 100 History of anaphylaxis, accelerated (e.g. hives) or History of anaphylaxis, accelerated (e.g. hives) Bacteriostatic antibiotics, anti-inflammatory,
Benzylpenicillin 5 mega units (3 g) i) Infections caused by susceptible organisms ii) agranulocytosis. Convulsions in the presence of
- mg/kg body weight daily IV in 2 - 4 divided doses ii) serum sickness reaction to previous penicillin or serum sickness reaction to previous penicillin antirheumatics, antipyretics, probenecids, oral
Injection Infective endocarditis severely reduced renal function, epilepsy,
ADULT: 7.2 g daily by slow IV infusion in 6 divided administration administration contraceptives
meningitis or cerebral oedema or during
doses
cardiopulmonary bypass procedure
Treatment of newborn baby with birth weight of 700 g
Continuous monitoring with arterial or
Beractant Intratracheal Suspension or greater undergoing mechanical ventilation for 100 mg/kg (4 ml/kg) body weight via endotracheal tube Transient bradycardia, hypoxia, endotracheal
Survanta transcutaneous measurement of systemic oxygen Not known Not known
(200 mg phospholipids in 8 ml vial) respiratory distress syndrome, whose heart rate and every 6 hours (1 - 4 doses) tube reflux
and carbon dioxide
arterial oxygenation are continuously monitored
Betahistine should not be given to patients with
phaeochromocytoma. It should be given with care to
Given in doses of 8 to 16 mg orally 3 times daily (total
Betahistine Dihydrochloride 16 mg Vertigo, tinnitus and hearing loss associated with patients with asthma, peptic ulcer disease or a
24 to 48 mg/day) preferably with food. CHILD not Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
Tablet Meniere's disease history of peptic ulcer disease. Antihistamines may
recommended
block some or all of intended effects of betahistine.
Liver disease, pregnancy, lactation
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Betahistine should not be given to patients with
phaeochromocytoma. It should be given with care to
Betahistine Dihydrochloride 24 mg Vertigo, tinnitus and hearing loss associated with patients with asthma, peptic ulcer disease or a
Betaserc® 24 mg twice daily Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
Tablet Meniere's disease history of peptic ulcer disease. Antihistamines may
block some or all of intended effects of betahistine.
Liver disease, pregnancy, lactation
Betahistine should not be given to patients with
phaeochromocytoma. It should be given with care to
Given in doses of 8 to 16 mg orally 3 times daily (total
Betahistine Dihydrochloride 8 mg Vertigo, tinnitus and hearing loss associated with patients with asthma, peptic ulcer disease or a
24 to 48 mg/day) preferably with food. CHILD not Nausea, vomiting, skin rash, pruritus Hypersensitivity, phaeochromocytoma Selegiline
Tablet Meniere's disease history of peptic ulcer disease. Antihistamines may
recommended
block some or all of intended effects of betahistine.
Liver disease, pregnancy, lactation
CYP3A3/4 enzyme substrate, phenytoin,
Suppression of inflammatory and allergic disorders, 0.5 - 9 mg daily in divided doses. CHILD: 0.5 - 7.5 Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle Systemic fungal infection (unless specific phenobarbital, potassium-depleting diuretics.
Betamethasone 0.5 mg Tablet Celestone
congenital adrenal hyperplasia, cerebral oedema mg/m2/day divided every 6 - 12 hours gradually weakness, peptic ulcer, Cushing's syndrome antimicrobial therapy given) Skin test antigens, immunizations:
Betamethasone may decrease response
Local skin atrophy, striae, systemic
Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.01- Eczemas, prurigo nodularis, limited psoriasis in Apply sparingly to affected area 2 - 3 times daily then Extensive or prolonged use, pregnancy, infant and hypercorticism, folliculitis, hypertrichosis,
Betnovate acne, rosacea and perioral dermatitis. Not known
0.05% Cream appropriate in sites reduced to once daily when improvement occurs children less than 4 years. Avoid contact with eyes acneiform eruptions, hypopigmentation and
Hypersensitivity to betamethasone products
allergic contact dermatitis
Local skin atrophy, striae, systemic
Extensive or prolonged use, pregnancy, infant and Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.01- Eczema, prurigo nodularis, limited psoriasis in Apply sparingly to affected area 2 - 3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 year. Avoid contact with eyes. acne, rosacea and perioral dermatitis. Not known
0.05% Ointment appropriate in sites reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation, prioral
Use in patients 12 years of age younger Hypersensitivity to betamethasone products
and allergic contact dermatitis
Local skin atrophy, striae, systemic
Extensive or prolonged use, pregnancy, infant and Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.1% Eczemas, prurigo nodularis, psoriasis (excluding Apply sparingly to affected area 2 - 3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 year. Avoid contact with eyes. acne, rosacea and perioral dermatitis. Not known
Cream widespread plaque psoriasis) reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation and
Use in patients 12 years of age younger Hypersensitivity to betamethasone products
allergic contact dermatitis
Local skin atrophy, striae, systemic
Extensive or prolonged use, pregnancy, infant and Viral diseases, bacteria and fungal infection,
Betamethasone 17-Valerate 0.1% Eczema, prurigo nodularis, psoriasis (excluding Apply sparingly to affected area 2-3 times daily then hypercorticism, folliculitis, hypertrichosis,
Betnovate children less than 4 years old. Avoid contact with acne, rosacea and perioral dermatitis. Not known
Ointment widespread plaque psoriasis) reduced to once daily when improvement occurs acneiform eruptions, hypopigmentation, prioral
eyes. Use in patients 12 years of age younger Hypersensitivity to betamethasone products
and allergic contact dermatitis
Viral, fungal, tuberculosis, purulent eye infection,
Betamethasone Disodium Phoshate Apply 2 - 3 drops every 2 - 3 hours, reduce frequency Prolonged use in infants, pregnancy, may result in
Betnesol Non-infected inflammatory conditions Local sensitivity reactions glaucoma, herpetic keratitis, otitis media, history As general with other corticosteroids
0.1% Ear Drops when relief obtained secondary fungal infections
of perforation of the ear drum
Viral, fungal, tuberculosis, purulent eye infection,
Betamethasone Disodium Phoshate Apply 2 - 3 drops every 2 - 3 hours, reduce frequency Prolonged use in infants, pregnancy, may result in
Betnesol Non-infected inflammatory conditions Local sensitivity reactions glaucoma, herpetic keratitis, otitis media, history As general with other corticosteroids
0.5% Ear Drops when relief obtained secondary fungal infections
of perforation of the ear drum
Red eye, steroid glaucoma, steroid cataract,
Bacterial, fungal, viral, tuberculous or purulent
Prolonged use in infants. May impair ability to drive thinning of the cornea and sclera, burning, dry
Betamethasone Disodium Phosphate 1 - 2 drops every 1 - 2 hours until controlled then conditions of the eye. Glaucoma, herpetic
Betnesol Non-infected inflammatory conditions of the eyes or operate machinery. Pregnancy. Withdrawal if eyes, photophobia, glaucoma, elevated Not known
0.1% Eye Drops reduce frequency keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection intraocular pressure, optic nerve damage,
any component of the preparation
cataract
Red eye, steroid glaucoma, steroid cataract,
Bacterial, fungal, viral, tuberculous or purulent
Prolonged use in infants. May impair ability to drive thinning of the cornea and sclera, burning, dry
Betamethasone Disodium Phosphate conditions of the eye. Glaucoma, herpetic
Celestone Non-infected inflammatory conditions of the eyes 2 - 4 times daily or at night when used with eye drops or operate machinery. Pregnancy. Withdrawal if eyes, photophobia, glaucoma, elevated Not known
0.1% Eye Ointment keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection intraocular pressure, optic nerve damage,
any component of the preparation
cataract
Viral, fungal infection, tuberculous, purulent eye
Betamethasone Disodium Phosphate Prolonged use in infants, may impair ability to drive
Apply 2 - 3 drops 3 - 4 times daily, reduce frequency Rise in intraocular pressure, epistaxis, ulceration infection, glaucoma, otitis media, history of
and Neomycin Sulphate 0.5% Ear Betnesol-N Allergic dermatosis in the ear and operate machinery, pregnancy, withdraw if there As general with other corticosteroids
when relief obtained of throat perforation of the ear drum, allergy to neomycin
Drops is spread of infection
or to any component of the preparation
Bacterial, fungal, viral, tuberculous or purulent
Prolonged use in infants. May impair ability to drive Rise in intraocular pressure, corneal ulcers.
Betamethasone Disodium Phosphate conditions of the eye. Glaucoma, herpetic
Betnesol-N Infected inflammatory conditions of the eyes 2 - 3 drops every 2 - 3 hours or operate machinery. Pregnancy. Withdrawal if Rarely, acute sensitization to neomycin, optic Not known
and Neomycin Sulphate Eye Drops keratitis (e.g. dendritic ulcer). Hypersensitivity to
there is spread of infection nerve damage, visual acuity and field defects
any component of the preparation
Usual intravenous doses are up to 9 mg/day of the
Pre-operative and in serious trauma or illness, shock,
sodium phosphate salt only. CHILD: IM: 0.5 - 7.7 mg
Betamethasone Sodium Phosphate 4 as adjunctive therapy in rheumatoid disorders, ocular, Discontinue treatment by reducing the dosage Fluid and electrolyte disturbances, muscle
Celestone base/m2/day divided every 6 - 12 hours. Systemic fungal infection Not known
mg/ml Injection dermatologic and respiratory allergic and inflammatory gradually weakness, peptic ulcer
ADOLESCENT and ADULT, IM: 0.6 - 9 mg divided
states
every 12 - 24 hours
Diabetes, thyrotoxicosis, patients with excessive Ocular stinging, pain, itching, erythema, dry eyes Epinephrine, catecholamine-depleting drugs,
Patients with bradycardia, heart block, or
Betaxolol 0.25% Eye Suspension Betoptic Chronic open-angle glaucoma, ocular hypertension One to two drops in the affected eye(s) twice daily restriction of pulmonary function, severe reactive and allergic blepharoconjunctivitis, corneal adrenergic psychotropic drugs, oral beta-
uncontrolled heart failure
airway disease, asthma, pregnancy disorders blockers
Enhanced coumarin anticoagulants effect,
Advanced prostate cancer in combination with LHRH 50 mg once daily. (morning or evening), with or without
Bicalutamide 50 mg Tablet Casodex Moderate to severe hepatic impairment GI disturbances, hot flushes, pain Women, children, pregnancy, lactation cimetidine, ketoconazole, cyclosporin and Ca-
analogue therapy or surgical castration. food. Take on the same time each day.
channel blockers
Eyelash formation, conjunctival hyperemia, iris
Aphakia, pseudoaphakia, active intraocular pigmentation, ocular pruritus, conjunctival
Bimatoprost 0.03% Ophthalmic Lowering of intraocular pressure in patients with open- Hypersensitivity to bimatoprost or any
Lumigan 1 drop in affected eye(s) once daily at evening inflammation, macular oedema, renal impairment, oedema, headache, hypertension, common cold, Latanoprost
Solution angle glaucoma and ocular hyperten component of the product
liver impairment, pregnancy, lactation acute upper respiratory infection, superficial
punctuate keratitis
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
i) ADULT and CHILD over 10 years: 10 mg, CHILD less
Prolonged use, abdominal pain, inflammatory bowel
i) Constipation ii) Bowel preparation for radiological than 10 years 5 mg insert rectally ii) ADULT 10-20 mg, Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 10 mg Suppository Dulcolax disease, sudden, persistent change in bowel habits Milk, antacids, warfarin
procedures and surgery CHILD over 4 years 5 mg the following morning before discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
and ulcerated haemorrhoids of rectal fissures
procedures insert rectally
i) ADULT and CHILD over 10 years: 10 mg, CHILD less
Prolonged use, abdominal pain, inflammatory bowel
i) Constipation ii) Bowel preparation for radiological than 10 years 5 mg insert rectally ii) ADULT 10-20 mg, Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 5 mg Suppository Dulcolax disease, sudden, persistent change in bowel habits Milk, antacids, warfarin
procedures and surgery CHILD over 4 years 5 mg the following morning before discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
and ulcerated haemorrhoids of rectal fissures
procedures insert rectally
i) ADULT and CHILD over 10 years 5-10 mg, CHILD 4-
10 years 5 mg. To be taken at night for effect on the
i) Constipation ii) Bowel preparation for radiological Prolonged use, abdominal pain, inflammatory bowel Rarely,electrolyte and fluid imblances, abdominal Ileus, intestinal obstruction, acute abdominal
Bisacodyl 5 mg Tablet Dulcolax following morning ii) ADULT 10-20 mg the night before Milk, antacids, warfarin
procedures and surgery disease, sudden, persistent change in bowel habits discomfort, diarrhoea, rectal burning, vomiting conditions, rectal bleeding, appendicitis
procedures, CHILD over 4 years 5 mg the night before
procedures
Bismuth Subgallate and Benzyl For relief of pruritus, burning and soreness in patients Insert 1 suppository night and morning after bowel Not for prolonged use. Use in children is not
Anusol Local irritation Hypersensitivity to any component of preparation Not known
Benzoate Suppository with haemorrhoids and perianal conditions movements; do not use for longer than 7 days recommended
As a mild antiseptic for wounds and abscesses. Sterile Erythematous rash, encephalopathy reported
Bismuth Subnitrate, Iodoform and Hyperthyroidism, nasal packing use not more than 3 Allergy to iodine or other components in the
BIPP gauze impregnated with paste for packing cavities after As directed for local application only with large packs or when placed directly on Not known
Liquid Paraffin Paste days. Ear packing use not more than 2 weeks preparations
otorhinological surgery neural tissue, nasal mucosal fibrosis
Avoid abrupt withdrawal; gradual withdrawal over a
Hypersensitivity, cardiac failure, pulmonary
period of 1 to 2 weeks is recommended. Arrythmia, bradycardia, chest pain, oedema, Prazosin, digoxin, amiodarone, ACEI,
Treatment of stable moderate to severe congestive oedema, pregnancy, severe asthma or severe
Bisoprolol Fumarate 2.5 mg Tablet Concor 1.25 mg once daily to 5 - 10 mg daily Bronchospastic disease, congestive heart failure, hypotension, dizziness, headache, fatique, antidiabetic agent, calcitriol, cholestyramine,
cardiac failure in addition to ACEI's and diuretics chronic obstructive pulmonary disease,
diabetes mellitus, hyperthyroidism/thyrotoxicosis. diarrhoea, nausea, impotency, cough, rhinitis clonidine
hypotension
Peripheral vascular and renal disease
Avoid abrupt withdrawal; gradual withdrawal over a
Hypersensitivity, cardiac failure, pulmonary
period of 1 to 2 weeks is recommended. Arrythmia, bradycardia, chest pain, oedema, Prazosin, digoxin, amiodarone, ACEI,
Treatment of stable moderate to severe congestive oedema, pregnancy, severe asthma or severe
Bisoprolol Fumarate 5 mg Tablet Concor 1.25 mg once daily to 5 - 10 mg daily Bronchospastic disease, congestive heart failure, hypotension, dizziness, headache, fatique, antidiabetic agent, calcitriol, cholestyramine,
cardiac failure in addition to ACEI's and diuretics chronic obstructive pulmonary disease,
diabetes mellitus, hyperthyroidism/thyrotoxicosis. diarrhoea, nausea, impotency, cough, rhinitis clonidine
hypotension
Peripheral vascular and renal disease
Beware of increased risk of pulmonary fibrosis in
elderly patients (more than 70 years), if radiotherapy
has been given to the chest, if cumulative lifetime
15 - 60 mg weekly in divided doses or 10 - 20 mg/m2 doses of bleomycin are exceeded or if high Erythema, hyperpigmentation of skin, nail
Squamous cell carcinoma, germ cell tumours,
once or twice weekly or 10 mg/m2 slow bolus in 15 concentrations of oxygen is given after bleomycin changes, mucositis, chills, fever, pneumonitis, Hypersensitivity to bleomycin, severe pulmonary Phenothiazines, cisplatinum, radiotherapy,
Bleomycin HCl 15 mg Injection Bleocin lymphomas. Routes: SC, IM, IV (either as bolus or as
minutes D1 and D15. Max: 400 mg. CHILD: 10 - 15 therapy. Monitor lung function. Risk of anaphylatic pulmonary fibrosis, Raynaud's phenomenon, disease, pregnancy, lactation zidovudine
infusion over 24 hours), intra-arterial, intra-pleural
mg/m2 over 6 hours every 3 - 4 weeks reaction is higher in patients with lymphoma hyperpyrexia, hyperkeratosis, striae, stomatitis
receiving bleomycin. Reconstitute in 0.9% sodium
chloride or sterile water. Should not reconstitute in
dextrose-containing solutions
Cumulative effect, if ingested can cause
Boric Acid with Spirit 2% w/v Ear gastrointestinal iritation, loss of appetite. Not Poisoning if absorbed too much, headache,
- Perforated eardrum 3 drops instilled into affected ear 3 - 4 times daily Not known Not known
Drops recommended for children below 3 years except with dermatitis
paediatrician consultation
Asthenic conditions, pyrexia, gastrointestinal
Concomitant use of antihypertensive medications, disturbances, anorexia, dehydration, peripheral
1.3 mg/ m2/dose given as IV bolus injection twice
dehydration, heart disease, hepatic impairment, neuropathy, thrombocytopenia, neutropenia,
weekly for two weeks (days 1, 4, 8, and 11) followed by
Treatment of multiple myeloma in patient who have renal impairment, high tumor burden prior to anaemia, hypotension, cardiac disorders, bone Hypersensitivity to bortezomib, boron or Cytochrome P450 3A4 inducer or inhibitors, oral
Bortezomib 3.5 mg Injection Velcade a 10- day rest period (days 12-21). At least 3 days
received at least one prior therapy treatment, myelosuppression, peripheral neuropathy and body pain, cough, dyspnoea, rash, oedema, mannitol. Child, pregnancy and lactation antidiabetic agents
should elapse between consecutive doses of
or other neurologic disorders, pulmonary disease, hypersensitivity reactions, painful or difficult
bortezomib
acute diffuse infiltrative, history of syncope urination, pneumonia, pyrexia, diarrhoea,
vomiting, dehydration and nausea
Severe cardiovascular disease, liver impairment, Oral dryness, ocular hyperemia, burning and
Alcohol, sedative, barbiturates, opiates,
Brimonidine Tartrate 0.15% Lowering of intraocular pressure in patients with open- renal impairment, depression, Raynauld?s stinging, headache, blurring, foreign body Hypersensitivity to brimonidine, concomitant
Alphagan P 1 drop in the affected eye(s) 3 times daily anaesthesia, tricyclic antidepressant, beta
Ophthalmic angle glaucoma or ocular hypertension phenomenon, orthostatic hypotension, sensation, fatigue, drowsiness, conjunctival MAOI therapy
blocker, antihypertensive
thromboangiitis obliterans, pregnancy, lactation follicles, ocular pruritus
May produce physical and psychological
Theophylline, decreased benzodiazepine
dependence, amnesia, may increase frequency and
effectiveness. Cimetidine may produce
3 - 18 mg daily in divided doses. 6 to 30 mg daily severity of grand mal seizure. Care in organic brain
Fatigue, muscle weakness, drowsiness, Shock, severe psychosis, pregnancy and bromazepam toxicity (CNS depression).
Bromazepam 3 mg Tablet Lexotan Anxiety disorders (single or divided doses) in anxiety-neurosis. Children disease, cardiorespiratory insufficiency, decreased
hypotension, nausea and vomiting breastfeeding Sedative effects increased by other centrally
not recommended hepatic or renal function. COPD or respiratory
acting drugs. Enhances CNS depressants effect
failure. Reduce dose in elderly and avoid chronic
of alcohol
use
Occasionally gastrointestinal effects, skin rashes
Secretolytic therapy in acute and chronic
very rarely. Gastrointestinal disturbances, May lead to higher antibiotic concentration in
Bromhexine HCl 4 mg/2 ml Injection Bisolvon bronchopulmonary diseases associated with abnormal 4 mg SC, IM or IV 2 - 3 times daily Gastrointestinal ulceration, pregnancy and lactation Hypersensitivity to bromhexine
headache, dizziness, sweating, skin rash, lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport
transient rise in serum transaminase
Nausea, anorexia, abdominal discomfort and
ADULT and CHILD more than 12 years : 10 ml 3 times
Secretolytic therapy in acute and chronic pain, headache, allergic reactions.
daily, 6 - 12 years : 5 ml 3 times daily, 2 - 6 years : 2.5 May lead to higher antibiotic concentration in
Bromhexine HCl 4 mg/5 ml Elixir Bisolvon bronchopulmonary diseases associated with abnormal Gastrointestinal ulceration, pregnancy and lactation Gastrointestinal disturbance, headache, Hypersensitivity to bromhexine
ml 3 times daily, less than 2 years : 1.25 ml 3 times lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport dizziness, sweating, skin rash, transient rise in
daily
serum transaminase
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Secretolytic therapy in acute and chronic ADULT and CHILD more than 12 years : 8 mg 3 times
Gastrointestinal ulceration, pregnancy and May lead to higher antibiotic concentration in
Bromhexine HCl 8 mg Tablet Bisolvon bronchopulmonary diseases associated with abnormal daily, 6 - 12 years : 4 mg 3 times daily, 2 - 6 years : 4 Gastrointestinal ulceration, pregnancy and lactation Hypersensitivity to bomhexine
lactation lung tissue. Oral anticoagulants
mucous secretion and impaired mucous transport mg 2 times daily
Clarithromycin - elevations in serum levels of
Nursing mothers, children under 15 years old, peptic
Hypotension, peripheral vasoconstriction, bromocriptine. Inhibit ciclosporin metabolism.
ulcer disease, postpartum, puerperal women with
i) Initially 1 - 1.25 mg at bedtime increased gradually, dyskinesias, fatigue, nausea, vomiting, Erythromycin - significantly increase the
high blood pressure, coronary artery disease,
usual dose: 7.5 mg daily in divided doses. Max 30 mg constipation, drowsiness, confusion, Hypersensitivity to bromocriptine products, bioavailability of bromocriptine. Bromocriptine,
psychic disorders, concomitant use of other ergot
Bromocriptine Mesilate 10 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
alkaloid. Fertility may be restored (contraception
increased by 1.25 - 2.5 mg every 3 - 7 days up to 30 dyskinesias, dryness of the mouth, leg cramps, postpartum and during puerperium tacrolimus . Alcohol reduces tolerance to
needed), malignancy excluded before use for benign
mg a day in divided doses allergic skin reactions. On prolonged treatment, bromocriptine and vice-versa. Effects of
breast disease, acromegalic patients with history of
reversible pallor of fingers and toes antihypertensives may be potentiated. Avoid
peptic ulceration
concurrent psychotropics
Clarithromycin - elevations in serum levels of
Nursing mothers, children under 15 years old, peptic
Hypotension, peripheral vasoconstriction, bromocriptine. Inhibit ciclosporin metabolism.
ulcer disease, postpartum, puerperal women with
i) Initially 1 - 1.25 mg at bedtime increased gradually, dyskinesias, fatigue, nausea, vomiting, Erythromycin - significantly increase the
high blood pressure, coronary artery disease,
usual dose: 7.5 mg daily in divided doses. Max 30 mg constipation, drowsiness, confusion, Hypersensitivity to bromocriptine products, bioavailability of bromocriptine. Bromocriptine,
psychic disorders, concomitant use of other ergot
Bromocriptine Mesilate 2.5 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
alkaloid. Fertility may be restored (contraception
increased by 1.25 - 2.5 mg every 3 - 7 days up to 30 dyskinesias, dryness of the mouth, leg cramps, postpartum and during puerperium tacrolimus . Alcohol reduces tolerance to
needed), malignancy excluded before use for benign
mg a day in divided doses allergic skin reactions. On prolonged treatment, bromocriptine and vice-versa. Effects of
breast disease, acromegalic patients with history of
reversible pallor of fingers and toes antihypertensives may be potentiated. Avoid
peptic ulceration
concurrent psychotropics
Clarithromycin - elevations in serum levels of
Nursing mothers, children under 15 years old, peptic
Hypotension, peripheral vasoconstriction, bromocriptine. Inhibit ciclosporin metabolism.
ulcer disease, postpartum, puerperal women with
i) Initially 1 - 1.25 mg at bedtime increased gradually, dyskinesias, fatigue, nausea, vomiting, Erythromycin - significantly increase the
high blood pressure, coronary artery disease,
usual dose: 7.5 mg daily in divided doses. Max 30 mg constipation, drowsiness, confusion, Hypersensitivity to bromocriptine products, bioavailability of bromocriptine. Bromocriptine,
psychic disorders, concomitant use of other ergot
Bromocriptine Mesilate 5 mg Tablet Parlodel i) Hypogonadism or Galactorrhoea ii) Acromegaly daily ii) 1.25 - 2.5 mg at bedtime for 3 days and may be psychomotor excitation, hallucinations, toxaemia of pregnancy, hypertension in may decrease the metabolism of sirolimus,
alkaloid. Fertility may be restored (contraception
increased by 1.25 - 2.5 mg every 3 - 7 days up to 30 dyskinesias, dryness of the mouth, leg cramps, postpartum and during puerperium tacrolimus . Alcohol reduces tolerance to
needed), malignancy excluded before use for benign
mg a day in divided doses allergic skin reactions. On prolonged treatment, bromocriptine and vice-versa. Effects of
breast disease, acromegalic patients with history of
reversible pallor of fingers and toes antihypertensives may be potentiated. Avoid
peptic ulceration
concurrent psychotropics
Mild irritation of the throat, coughing, and
Acute exacerbations, accompanied by increased Oral or parenteral corticosteroids - effects
generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic ADULT : Initially 1 - 2 mg twice daily. CHILD 3 months - mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Budesonide 1 mg/2 ml Nebulising Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Pulmicort therapy especially if not fully controlled by 12 years of age : 500 mcg - 1 mg. Maintenance dose : viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
Solution the mouth and throat, paradoxical severe bronchiectasis
bronchodilators half of the above doses and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
bronchoconstriction, headache, nausea,
Pregnancy and lactation increased budesonide plasma concentrations
tiredness, thirst, diarrhoea, skin reaction
Mild irritation of the throat, coughing, and
Acute exacerbations, accompanied by increased Oral or parenteral corticosteroids - effects
ADULT : 200 - 1600 mcg daily in 2 - 4 divided doses. generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Maintenance with twice daily dosing. CHILD more than Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Budesonide 100 mcg/dose Inhalation Pulmicort therapy especially if not fully controlled by viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
7 years 200 - 800 mcg, 2 - 7 years 200 - 400 mcg. To the mouth and throat, paradoxical severe bronchiectasis
bronchodilators and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
be taken orally in 2 - 4 divided doses bronchoconstriction, headache, nausea,
Pregnancy and lactation increased budesonide plasma concentrations
tiredness, thirst, diarrhoea, skin reaction
Not for acute attack. Taper dose when discontinuing
ADULT : 1 - 2 puff twice daily, maximum : 4 puff twice treatment. Thyrotoxicosis, diabetes mellitus, heart
Budesonide 160 mcg and Formoterol Headache, insomnia, tremor, restlessness, oral Hypersensitivity to budesonide or formoterol or Itraconazole, ketoconazole, MAOI, tricyclic
Symbicort Mild, moderate and severe persistent asthma daily. ADOLESCENT (12 - 17 years) : 1 - 2 puff twice disease, hypokalaemia, severe cardiovascular
4.5 mcg Inhalation candidiasis, cough, hoarseness inhaled lactose antidepressan, ritonavir, phenothiazines
daily. CHILD less than 6 years are not recommended disorders, hypertropic obstructive cardiomyopathy,
tuberculosis, phaeocromocytoma
Mild irritation of the throat, coughing, and
Acute exacerbations, accompanied by increased Oral or parenteral corticosteroids - effects
ADULT : 200 - 1600 mcg daily in 2 - 4 divided doses. generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Maintenance with twice daily dosing. CHILD more than Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Budesonide 200 mcg/dose Inhalation Pulmicort therapy especially if not fully controlled by viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
7 years 200 - 800 mcg, 2 - 7 years 200 - 400 mcg. To the mouth and throat, paradoxical severe bronchiectasis
bronchodilators and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
be taken orally in 2 - 4 divided doses bronchoconstriction, headache, nausea,
Pregnancy and lactation increased budesonide plasma concentrations
tiredness, thirst, diarrhoea, skin reaction
Mild irritation of the throat, coughing, and
Acute exacerbations, accompanied by increased Oral or parenteral corticosteroids - effects
generally reversible hoarseness of the voice.
Maintenance treatment of asthma as prophylactic ADULT : Initially 1 - 2 mg twice daily. CHILD 3 months - mucous viscosity and mucous plugging. Caution in enhanced by the concomitant use. Amiodarone -
Budesonide 500 mcg/2 ml Nebulising Bad taste, dryness of the throat. Candidiasis of Hypersensitivity to budesonide. Moderate to
Pulmicort therapy especially if not fully controlled by 12 years of age : 500 mcg - 1 mg. Maintenance dose : viral infections such as varicella, in untreated fungal increased risk of developing Cushing's
Solution the mouth and throat, paradoxical severe bronchiectasis
bronchodilators half of the above doses and bacterial infections of the respiratory system. syndrome. Ketoconazole, erytromycin, ritonavir -
bronchoconstriction, headache, nausea,
Pregnancy and lactation increased budesonide plasma concentrations
tiredness, thirst, diarrhoea, skin reaction
ADULT and CHILD 6 years and older. Rhinitis : 2 spray Nasal irritation, nose bleeding, dryness of throat, Erythromycin, clarithromycin, lansoprazole,
Severe fungal and viral nasal infections, chronic use, Severe nasal infection, recurrent nasal bleeding,
into each nostril once daily in the morning or 1 spray epistaxis, pharyngitis, cough, nasal irritation, amoxicillin, fluvoxamine, itraconazole,
Budesonide 64mcg Nasal Spray Rhinocort Aqua Seasonal allergic, perennial rhinitis and nasal polyposis liver cirrhosis, reduce liver function, pulmonary hypersensitivity to budesonide products, status
into each nostril twice daily. Nasal polyps : 2 spray bronchospasm, cataract, cushing's syndrome, ketoconazole, protease inhibitors, voriconazole,
tuberculosis, glaucoma, adrenal suppression asthmaticus or other acute episodes of asthma
twice daily glaucoma, secondary hypocortisolism cimetidine

Alterations in glucose metabolism, blood dyscrasias Amikacin, angiotensin converting enzyme


(thrombocytopenia), hepatic disease, inhibitors, digitoxin, digoxin, gentamicin,
IV injection: 1 - 2 mg repeated after 20 mins. IV Hypokalaemia, hyperuricaemia, muscle cramps, Hypersensitivity to bumetanide products, anuria,
Bumetanide 0.5 mg/ml Injection Burinex Oedema used in furosemide allergic patient hyperuricaemia, hypokalaemia, hypovolaemia, kanamycin, lithium, neomycin, netilmicin,
infusion: 2 - 5 mg over 30 - 60 mins arthralgias severe electrolyte imbalance, hepatic coma
ototoxicity particularly potentiation of aminoglycoside nonsteroidal antiinflammatory agents,
ototoxicity, coadministration not recommended streptomycin, tobramycin
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Angiotensin converting enzyme inhibitors:
Alterations in glucose metabolism, blood dyscrasias
postural hypotension (first dose). Digoxin:
(thrombocytopenia), hepatic disease,
1 mg in the morning, repeat after 6 - 8 hours if Hypokalaemia, hyperuricaemia, muscle cramps, Hypersensitivity to bumetanide products, anuria, digoxin toxicity (nausea, vomiting, cardiac
Bumetanide 1 mg Tablet Burinex Oedema used in furosemide allergic patient hyperuricaemia, hypokalaemia, hypovolaemia,
necessary. Up to 5 mg daily in severe cases arthralgias severe electrolyte imbalance, hepatic coma arrhythmias). Gentamicin: ototoxicity.
ototoxicity particularly potentiation of aminoglycoside
Kanamycin: increased risk of ototoxicity
ototoxicity, coadministration not recommended
(tinnitus).
Light headedness, nervousness, apprehension,
euphoria, confusion, dizziness, drowsiness,
tinnitus, blurred vision, diplopia, nausea,
vomiting, sensations of heat, cold or numbness,
urinary retention, paraesthesia circumoral,
hyperacusis, twitching, tremors, convulsions,
Neurological disorder, serious CNS or spinal cord unconsciousness, resp depression and/or arrest,
diseases, hypoxaemia, acidosis, hyperkalaemia, agitation, numbness of tongue, difficulty in
predisposition to malignant hypothermia, pregnancy. swallowing & slurred speech. Cardiovascular:
Resuscitative equipment & drugs should be bradycardia, hypotension. Haemodynamic:
Hypovolaemia, complete heart block,
immediately available. Elderly, young or debilitated maternal hypotension. Neurologic: spinal block
intravenous regional anaesthesia (Bier's block).
patients, advanced liver disease, severe renal of varying magnitude (including total spinal
Allergy or hypersensitivity to amide type local Hyaluronidase, propofol, rapacuronium. May
Bupivacaine 0.125% Epidural Infuse at 6 - 15 ml/hour. Not to exceed 2 mg/kg in a impairment, children less than 12 year. Epilepsy, block), hypotension secondary to spinal block,
Marcaine Epidural Epidural analgesia for postoperative pain relief. anesth. Epidural or spinal anesth in patients with potentiate class III antiarrhythmics (eg mexiletine
Injection single dose. impaired cardiac conduction, bradycardia, severe loss of bladder & bowel control & loss of perineal
uncorrected hypotension. Infection and/or & lignocaine), verapamil
shock or digitalis intoxication, impaired sensation & sexual function. Persistent motor,
septicaemia. Obstetric paracervical block, IV
cardiovascular function, Stokes-Adams syndrome, sensory and/or autonomic (sphincter control)
regional anesth (Bier's block)
Wolff-Parkinson-White syndrome. Preexisting deficit of some lower spinal segments with slow
neurological or neuromuscular disease, recovery (several month) or incomplete recovery
hyperthyroidism. May temporarily impair locomotion in rare instances when caudal/lumbar epidural
or coordination block has been attempted. Backache &
headache. Neuropathy, peripheral nerve injury &
arachnoiditis. Inadvertent subarachnoid inj may
lead to Central nervous system depression, resp
arrest & cardivascular collapse. Allergic:
cutaneous lesions, urticaria, oedema or
anaphylactoid reactions.

Hypovolaemia, complete heart block,


Neurological disorder, severe bradycardia, cardiac intravenous regional anaesthesia (Bier's block).
conduction abnormalities, hypoxaemia, acidosis, Acute active disease of the CNS eg meningitis,
hyperkalaemia, predisposition to malignant tumours, poliomyelitis & cranial haemorrhage,
hypothermia, pregnancy. Resuscitative equipment & Confusion, nervousness, dizziness, tinnitus, active TB or metastatic lesions in the vertebral
Marcaine Spinal ADULT: 2 - 4 ml. Not to exceed 2 mg/kg in a single Hyaluronidase, propofol, rapacuronium,
Bupivacaine 0.5 % Heavy Injection Used for spinal anaesthesia drugs should be immediately available. respiratory depression and convulsion, column. Septicaemia. Pernicious anaemia with
Heavy dose verapamil, antiarrhythmias.
Hypovolaemia due to haemorrhage or dehydration, hypotension and bradycardia, hypersensitivity subacute combined degeneration of the spinal
aortocaval occlusion, coronary or cerebrovascular cord. Pyrogenic infection of the skin at or
disease. Chronic neurological disorders. May impair adjacent to the site of puncture. Cardiogenic or
ability to drive or operate machinery hypovolaemic shock. Coagulation disorders or
ongoing anticoagulant treatment
Hypovolaemia, complete heart block,
intravenous regional anaesthesia (Bier's block).
Acute active disease of the CNS eg meningitis,
Confusion, nervousness, dizziness, tinnitus,
tumours, poliomyelitis & cranial haemorrhage,
Regional nerve block or epidural block: 15 - 30 ml. Neurological disorder, severe bradycardia, cardiac respiratory depression and convulsion,
For peripheral sympathetic nerve and epidural active TB or metastatic lesions in the vertebral
Nerve block of finger or toe: 2 - 6 ml. Maximum: 2 conduction abnormalities, hypoxaemia, acidosis, hypotension and bradycardia, hypersensitivity, Hyaluronidase, propofol, rapacuronium,
Bupivacaine 0.5 % Injection Marcaine (excluding caudal) anaesthesia and obstetrics column. Septicaemia. Pernicious anaemia with
mg/kg body weight in any 4 hours period, equivalent to hyperkalaemia, predisposition to malignant arrhythmias and cardiac arrest; verapamil, antiarrhythmias
anaesthesia subacute combined degeneration of the spinal
25 - 30 ml in adults of average weight hypothermia, pregnancy methemoglobinaemia; seizures, restlessness.
cord. Pyrogenic infection of the skin at or
Prolonged block
adjacent to the site of puncture. Cardiogenic or
hypovolaemic shock. Coagulation disorders or
ongoing anticoagulant treatment
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Preexisting neurological or neuromuscular disease


eg myasthenia gravis; CNS or spinal cord disease
eg meningitis, spinal fluid block, cranial or spinal
haemorrhage, tumours, poliomyelitis, syphilis, TB or
Light headedness, nervousness, apprehension,
metastatic lesions of the spinal cord, severe hepatic
euphoria, confusion, drowsiness, tinnitus, blurred
disease, severe renal dysfunction, hyperthyroidism,
vision, diplopia, nausea, vomiting, sensations of
epilepsy, severe bradycardia, severe cardiac
heat, cold or numbness, urinary retention,
conduction abnormalities, severe shock or digitalis
paraesthesia circumoral, hyperacusis, twitching,
intoxication, Stokes-Adams or Wolff-Parkinson-
tremors, convulsions, unconsciousness, resp
White syndrome, hypoxaemia, acidosis,
depression &/or arrest, agitation, numbness of May potentiate the cardiac effects of
hyperkalaemia, predisposition to malignant Allergy or hypersensitivity to amide type local
the tongue, difficulty in swallowing & slurred antiarrhythmics (eg mexiletine & lignocaine).
hypothermia, fetal bradycardia/tachycardia anesth. Epidural or spinal anesth in patients with
speech. CV: bradycardia, hypotension: CNS acting drugs: tricyclic antidepressants or
frequently follows paracervical block with some uncorrected hypotension. Infection and/or
Haemodynamic: maternal hypotension. MAOIs, phenothiazines & butyrophenones.
amide type local anesth & may be associated with septicaemia. Obstetric paracervical block, IV
10 - 40 ml (0.25 %) or maximum : 2 mg/kg body weight Neurologic: spinal block of varying magnitude Oxytocic drugs of the ergot type. Adrenergic
Bupivacaine 0.5 % with Adrenaline fetal acidosis & hypoxia. Added risk in prematurity, regional anesth (Bier's block). Thyrotoxicosis;
Marcaine-Adrenaline Regional nerve block or epidural block. in any 4 hours period, equivalent to 25 - 30 ml of 0.5% (including total spinal block), hypotension neuron blocking agents eg guanethidine,
1:200,000 Injection toxaemia of pregnancy & fetal distress. Monitor fetal regions with compromised blood supply,
solution secondary to spinal motor, sensory &/or debrisoquine, bethanidine. β-blocker eg
heart rate. Pregnancy. Allergic type reactions extremities. severe hemorrhage, severe
autonomic (sphincter control) deficit of some propranolol. Inhalation anesth eg chloroform,
including anaphylactic type symptoms & life- hypotension or shock and arrhythmias, such as
lower spinal segment w/ slow recovery (several halothane, cyclopropane, trichloroethylene or
threatening or less severe asthmatic episodes in complete heart block, which severely restrict
mth) or incomplete recovery in rare instances other halogenated cmpds. Cardiac glycosides,
certain susceptible people. Extreme caution in cardiac output (spinal anesthesia)
when caudal or lumbar epidural block has been quinidine, hypoglycaemics
patients with severe or untreated hypertension,
attempted. Backache & headache. Neuropathy,
poorly controlled thyrotoxicosis, ischaemic heart
peripheral nerve injury & arachnoiditis.
disease, heart block, cerebrovascular insufficiency,
Inadvertent subarachnoid inj may lead to CNS
advanced diabetes & any other pathological
depression, resp arrest & CV collapse. Allergic:
condition that might be aggravated by effects of
cutaneous lesions, urticaria, oedema or
adrenaline. Adrenaline may induce anginal pain in
anaphylactoid reactions
patients suffering from ischaemic heart disease.
Ventricular fibrillation, prefibrillatory rhythm,
tachycardia, myocardial infarction, phenothiazine-
induced circulatory collapse & prostatic hypertrophy
i) ADULT: Initial: 2 - 4 mg daily. Maintenance: 0.5 - 2 Myelosuppression, cataracts, hyperpigmentation,
mg daily. Stop when white blood cell less than 20 x diffuse interstitial pulmonary fibrosis,
i) Chronic myeloid leukaemia (CML) and other 109/L. CHILD: 60 mcg/kg body weight daily ii) CHILD: Monitor blood counts during therapy. Caution in gastrointestinal disturbances, veno-occlusive
Hypersensitivity to busulphan. Pregnancy and
Busulphan 2 mg Tablet Myleran myeloproliferative diseases ii) Haemopoietic stem cell Induction 60 mcg/kg body weight daily (maximum 4 mg) patients given radiotherapy or cytotoxic drug therapy disease, gynaecomastia, convulsions, impaired Itraconazole, paracetamol, live vaccines
lactation
transplant (HSCT)- refer to specific protocols if leucocytes more than 20,000/mm3 and platelets more recently fertility and gonadal function, endocardial
than 100,000/mm3. Maintenance 10 - 30mcg/kg fibrosis, adrenal suppression, secondary
(maximum 2 mg daily) malignancy
Orthostatic hypotension, valvular regurgitation,
Eclampsia, pre-eclampsia or pregnancy induced abdominal pain, vertigo, pleural effusion,
i) Hyperprolactinaemia: 0.25 mg 1-2 times per week ii) Hypersensitivity to cabergoline or potent
i) Treatment of hyperprolactinaemic disorders ii) hypertension. Do not administer dopamine D2 pulmonary fibrosis, constipation, nausea, Activity and tolerability may be affected by
HIV mothers only: Prevent lactation 2 tab first day after inhibitors of CYP3A4 (includes protease
Cabergoline 0.5 mg Tablet Dostinex Prevention of puerperal lactation and suppression of receptor antagonists concurrently. High initial doses dizziness, headache, somnolence, depression, antiemetics, antihypertensives, psychotropics
delivery. Interruption of lactation: 0.25 mg 12 hourly for inhibitors, azole antifungals and some macrolide
lactation in HIV infected mothers only (1mg), especially with concurrent antihypertensive fatigue, sleeplessness, dyspepsia, gastritis, and macrolide antibiotics
2 days antibiotics), uncontrolled hypertension
regimens, liver disease weakness, fatigue, constipation, vomiting, breast
pain, hot flushes, depression, tingling
Avoid contact with eyes and other mucous
Calamine Cream - Prickly heat or insect bites Apply to the affected area as required Rash or irritation Not known Not known
membranes
Apply to the skin as required and allow to dry, 1-3 times Avoid contact with eyes and other mucous
Calamine Lotion - Prickly heat or insect bites Rash or irritation Not known. Not known
daily membranes
Avoid contact with eyes and other mucous
Calamine with 0.25 - 0.5% Menthol Apply to the skin as required and allow to dry, 1 - 3
- Prickly heat or insect bites membranes. Do not use on children under 2 years Rash or irritation Not known Not known
Lotion times daily
without consulting a physician
Aviod contact with eyes and other mucous
membranes. Do not use on children under 2 years
Calamine with 0.5% Phenol Cream - For use as a mild astringent Apply to the affected area as required Rash or irritation Pregnancy, paediatrics and geriatrics Not known
without consulting a physician. Should not be applied
to large areas of skin or large wounds
Avoid contact with eyes and other mucous
Calamine with 2 - 6% Precipitated Apply to the skin as required and allow to dry, 1 - 3
- Acne vulgaris membranes. Do not use on children under 2 years Rash or irritation Not known Not known
Sulphur Lotion times daily
without consulting a physician
Apply to the affected skin lesions twice daily.
Should not be used on the face since the formulation
Maintenance therapy may be achieved with less Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/g Cream Daivonex Only for the treatment of Psoriasis Vulgaris may give rise to irritation of the facial skin. Careful Not known
frequent application. The weekly dose should not dermatitis may occur, hypercalcaemia calcipotriol. Disorders of calcium metabolism
handwashing after use is recommended
exceed 100 g.
Apply to the affected skin lesions twice daily. Should not be used on the face since the ointment
Maintenance therapy may be achieved with less formulation may give rise to irritation of the facial Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/g Ointment Daivonex Only for the treatment of Psoriasis Vulgaris Not known
frequent application. The weekly dose should not skin. Careful handwashing after use is dermatitis may occur, hypercalcaemia calcipotriol. Disorders of calcium metabolism
exceed 100 g recommended
Apply to the affected skin lesions twice daily. Weekly
Should not be used on the face since the formulation
maintenance therapy may be achieved with less Transient local irritation and very rarely, facial Hypersensitivity to any constituents of the
Calcipotriol 50 mcg/ml Scalp Solution Diavonex Only for the treatment of Psoriasis Vulgaris may give rise to irritation of the facial skin. Careful Not known
frequent application. The weekly dose should not dermatitis may occur and hypercalcaemia calcipotriol. Disorders of calcium metabolism
handwashing after use is recommended
exceed 100 g
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Disorders of calcium metabolism, viral, fungal or Alatrofloxacin, alcuronium, Amphotericin B


bacterial skin infections, parasitic infections, skin Liposome, Anthrax Vaccine Adsorbed, Anthrax
Calcipotriol Hydrate 50 mcg/g & Apply once daily up to 4 weeks with maximum weekly Avoid contact with face and eyes. Avoid application Pruritus, rash, local transient irritation, dermatitis,
manifestations in relation to tuberculosis or Vaccine Adsorbed, Bacillus of Calmette and
Betamethasone Dipropionate 0.5 Daivobet Resistant plaque psoriasis dose of 100g and maximum treatment area 30% of on large areas of damaged skin, under occlusive erythema, aggravation of psoriasis,
syphilis, rosacea, acne rosacea, perioral Guerin Vaccine Live, Carbamazepine,
mg/g Ointment body surface dressings or in skin folds. Pregnancy and lactation photosensitivity and hypersensitivity reactions
dermatitis, acne vulgaris, skin atrophy, striae Ciprofloxacin, Diphtheria Toxoid, Adsorbed,
atrophicae, fragility of skin Ethinyl Estradiol, Etonogestrel
5 - 10 IU/kg/day SC/IM (in 1 - 2 divided doses) to 400
Ketoprofen inhibit the calciuric and uricosuric
units every 6 - 8 hours adjusted according to clinical Nausea, vomiting, flushing, chills, dizziness,
Calcitonin (synthetic Salmon) 100 IU Pregnancy, lactation, caution when driving vehicles effects of calcitonin. Calcitonin cause a
Miacalcic Acute hypercalcaemia and biochemical response (no additional benefit with polyuria. Rarely, local hypersensitivity reactions, Hypersensitivity to calcitonin
Injection or operating machinery significant decrease in the mean values of lithium
over 8 units/kg every 6 hours. 5 - 10 units/kg slow IV anaphylactoid-like reactions
plasma levels
over at least 6 hours
Rhinitis, ulcerative rhinitis, sinusitis, epitaxis,
Pregnancy, lactation, caution when driving vehicles flushing, dizziness, headache, gastrointestinal Ketoprofen inhibit the calciuric and uricosuric
Calcitonin (Synthetic Salmon) 200 IU or operating machine. Should not be given to disturbances, musculoskeletal pain, pharyngitis, effects of calcitonin. Calcitonin cause a
Miacalcic Osteoporosis 200 units daily Hypersensitivity to calcitonin
Nasal Spray children more than a few weeks. Possibility of fatigue, dysgeusia. Rarely, hypertension, significant decrease in the mean values of lithium
systemic allergic reaction exists vomiting, arthralgia, cough, oedema, flu-like plasma levels
symptoms, abnormal vision
5 - 10 IU/kg/day SC/IM (in 1 - 2 divided doses) to 400
Ketoprofen inhibit the calciuric and uricosuric
units every 6 - 8 hours adjusted according to clinical Nausea, vomiting, flushing, chills, dizziness,
Calcitonin (Synthetic Salmon) 50 IU Pregnancy, lactation, caution when driving vehicles effects of calcitonin. Calcitonin cause a
Miacalcic Acute hypercalcaemia and biochemical response (no additional benefit with polyuria. Rarely, local hypersensitivity reactions, Hypersensitivity to calcitonin
Injection or operating machinery significant decrease in the mean values of lithium
over 8 units/kg every 6 hours. 5 - 10 units/kg slow IV anaphylactoid-like reactions
plasma levels
over at least 6 hours
i) 0.25 mcg 2 times daily ii) Initial dose 0.25 mcg. In Monitor serum calcium, phosphorus, magnesium
Treatment of: i) Postmenopausal osteoporosis ii) Renal patients with normal or only slightly reduced serum and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Hypercalcaemia, vitamin D toxicity, abnormal Cytochrome P450 effect. Cholestyramine,
osteodystrophy in patients on haemodialysis iii) calcium levels, doses of 0.25 mcg every other day is phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 0.25 mcg Capsule Rocaltrol sensitivity to the effects of vitamin D, thiazides diuretics, corticosteroids, magnesium-
Hypoparathyroidism and rickets iv) Secondary sufficient iii) 0.25 mcg/day given in the morning iv) lactation. Take care to ensure correct dose to mouth, constipation, muscle pain, bone pain,
malabsorption syndrome containing antacids, digitalis
hyperparathyroidism in renal failure ADULT and CHILD 3 years and older : Initially 0.25 infants, monitor plasma calcium and creatinine metallic taste
mcg/ml. CHILD less than 3 years : 10 to 15 ng/kg/day during dosage titration
Monitor serum calcium, phosphorus, magnesium
and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Management of hypocalcaemia and/or secondary Initially dose, depending on severity, 1 mcg (0.02 Hypercalcaemia, metastatic calcification, vitamin Cytochrome P450 effect. Cholestyramine,
phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 1 mcg/ml Injection Calcijex hyperparathyroidism in patients undergoing chronic mg/kg) to 2 mcg 3 times weekly, approximately every D toxicity and hypersensitivity to calcitriol thiazides diuretics, corticosteroids, magnesium-
lactation.Take care to ensure correct dose to infants, mouth, constipation, muscle pain, bone pain,
renal dialysis other day products containing antacids, digitalis
monitor plasma calcium and creatinine during metallic taste
dosage titration
Monitor serum calcium, phosphorus, magnesium
and alkaline phosphatase, urinary calcium and Hypercalcaemia, nausea, vomiting, polydipsia,
Management of hypocalcaemia and/or secondary Hypercalcaemia, metastatic calcification, vitamin Cytochrome P450 effect. Cholestyramine,
Initially dose, depending on severity, 1 mg (0.02 mg/kg) phosphorus. Patients on digitalis. Pregnancy and polyuria, weakness, headache, somnolence, dry
Calcitriol 2 mcg/ml Injection Calcijex hyperparathyroidism in patients undergoing chronic D toxicity and hypersensitivity to calcitriol thiazides diuretics, corticosteroids, magnesium-
to 2 mg 3 times weekly, approximately every other day lactation.Take care to ensure correct dose to infants, mouth, constipation, muscle pain, bone pain,
renal dialysis products containing antacids, digitalis
monitor plasma calcium and creatinine during metallic taste
dosage titration
Co-administration with thiazide diuretics or
vitamin D may lead to milk-alkali syndrome and
hypercalcaemia. Decreased absorption with
To be used only for elemental calcium supplementation Gastrointestinal irritation, constipation, flatulence, Patients with calcium renal calculi or history of corticosteroids. Decreases absorption of
Renal impairment, hypercalcaemia-associated
Calcium Carbonate 500 mg Capsule - and phosphate binding activity in patients with chronic Initial 2.5 g daily and increased up to 17 g daily gastric hypersecretion and acid rebound, renal calculi, hypercalcaemia, tetracyclines, atenolol, iron, quinolones,
disease eg, other malignancies, sarcoidosis, elderly
renal failure hypercalcaemia, alkalosis and renal dysfunction hypophosphataemia alendronate, natrium fluoride, zinc and calcium-
channel blockers. Enhances cardiac effects of
digitalis glycosides and may precipitate digitalis
intoxication
Co-administration with thiazide diuretics or
vitamin D may lead to milk-alkali syndrome and
hypercalcaemia. Decreased absorption with
To be used only for elemental calcium supplementation Gastrointestinal irritation, constipation, flatulence, Patients with calcium renal calculi or history of corticosteroids. Decreases absorption of
Renal impairment, hypercalcaemia-associated
Calcium Carbonate 500 mg Tablet and phosphate binding activity in patients with chronic Initial 2.5 g daily and increased up to 17 g daily gastric hypersecretion and acid rebound, renal calculi, hypercalcaemia, tetracyclines, atenolol, iron, quinolones,
disease eg, other malignancies, sarcoidosis, elderly
renal failure hypercalcaemia, alkalosis and renal dysfunction hypophosphataemia alendronate, natrium fluoride, zinc and calcium-
channel blockers. Enhances cardiac effects of
digitalis glycosides and may precipitate digitalis
intoxication
Renal impairment, haematuria, proteinuria, cerebral
Nephrotoxicity, malaise, chills, thirst, nausea,
60 - 70 mg/kg body weight daily given IV infusion in 2 oedema. Capable of producing toxic effects which
vomiting, diarrhoea, abdominal pain, injection
Calcium Disodium Edetate 200 mg daily doses for up to 5 days; repeated if necessary after can be fatal, patients with lead encephalopathy, Hypersensitivity to edetate products, anuria or
Ca Disod. Versenate Lead Poisoning site pain, myalgia, headache, hypotension Not known
Injection an interval of 2 days. Any further treatment with calcium administer only after adequate urine flow is active renal disease, hepatitis
(frequent), thrombophlebitis (frequent), immune
edetate should not be recommended for 7 days established, children must be given adequate oral
hypersensitivity reaction
fluids during outpatient therapy
i) 1-2 g (2.25-4.5 mmol). CHILD 50 mg/kg ii) ADULT 1g
Increased inotropic and toxic effects when used
i) Acute hypocalcaemia ii) Hypocalcaemic tetany iii) (2.2 mmol) by slow IV injection followed by continuous Extravasation during IV injection. Renal impairment, Sloughing or necrosis of the skin, soft tissue Hypercalcaemia, hypercalciurea, severe renal
Calcium Gluconate 10% Injection with cardiac glycosides. Complex formation with
Cardiac resuscitation infusion of 4 g (8.8 mmol) daily iii) IV or intracardiac cardiac disease or sarcoidosis calcification. Hypercalcaemia (excessive use) failure, patients treated with digitalis
tetracyclines
injection, 10 ml
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

Allopurinol, aspirin, chlorothiazide, ciprofloxacin,


Calcium enhances the effect of cardiac glycosides
digoxin, doxycycline, hydrochlorothiazide,
on the heart and may precipitate arrhythmias. In Ventricular fibrillation during cardiac
For prophylaxis of calcium deficiency and treatment of Mild gastrointestinal disturbances, bradycardia, itraconazole, ketoconazole, levothyroxine,
Calcium Lactate 300 mg Tablet - ADULT 1-5 g daily in divided doses large doses, monitor serum calcium concentration resuscitation, hypercalcaemia, hypercalciuria,
chronic hypocalcaemia arrhythmias metolazone, minocycline, norfloxacin, ofloxacin,
and kidney function weekly, renal impairment, severe renal failure
oxytetracycline, pefloxacin, tetracycline,
history of renal stones
ticlopidine, verapamil, zalcitabine
Digitalis preparation, antacid and laxatives
Patients should be monitored for electrolytes Bronchopneumonia associated with inhalation of Should be avoided in patients with conditions containing aluminium, magnesium or calcium,
15 - 30g daily in 2-3 divided doses. Each dose should disturbances, especially hypokalaemia and calcium polystyrene sulphonate. Anorexia, such as hyperparathyroidism, multiple myeloma, dried aluminium hydroxide gel, magnesium
Calcium Polystyrene Sulphonate Hyperkalemia resulting from acute or chronic renal
Kalimate be suspended in 30 - 50ml of water and administered hypercalcaemia. May cause perforation in intestine, nausea, vomiting, constipation, diarrhea, colon sarcoidosis, or metastatic carcinoma who may hydroxide, precipitate calcium carbonate.
Powder failure
orally necrosis in mucous membrane of intestine, large perforation, hypopotassaemia, calcium present with renal failure together with Calcium ions are released from the resin in the
intestine ulcer, colon necrosis overloading and hypercalcaemia hypercalcaemia gastrointestinal tract and this may reduce the
absorption of tetracycline given by mouth
i)Metastatic breast cancer in elderly and poor Myelosuppression, oedema, fatigue, fever,
i) & ii) 1250 mg/m2 twice daily (morning and evening)
performance status patients and refractory to taxanes Patient with bone marrow suppression, poor abdominal pain, palmar-plantar Hypersensitivity to capecitabine, fluorouracil or
for 2 weeks, every 21 days iii) Recommended for a total
Capecitabine 500 mg Tablet Xeloda ii) Metastatic colon cancer, first line in elderly and poor nutritional status, elderly patients (more than 80 erythrodysesthesia, dermatitis, nausea and any component of formulation, severe renal Warfarin
of 24 weeks (8 cycles of 2 weeks of drug administration
performance status patients iii) Colon cancer, adjuvant years), hepatic or renal dysfunction vomiting, stomatitis, anorexia, diarrhoea, impairment, pregnancy, lactation
and 1 week rest period
therapy for stage III (Duke's Stage C) following surgery constipation, paraesthesia

i) Initially 12.5 mg twice daily. Maintenance: 50 mg 2 - 3 Anaphylaxis during lipid apheresis with dextran Angioedema induced by other angiotensin
times daily, may be increased to maximum 450 mg/day sulfate membranes and during hymenoptera converting enzyme (ACE) inhibitors during prior May increase serum K with Kalium K-sparing
Rash, pruritus, flushing, angioedema, loss of
i) Hypertension ii) Congestive heart failure iii) Post- ii) Initially 6.25 - 12.5 mg 3 times daily, increase after desensitization, angioedema; discontinue if laryngeal exposure. Anuric renal failure during prior diuretics. Hypotensive effects enhanced by
Captopril 25 mg Tablet Capoten taste perception, stomatitis, gastrointestinal
myocardial infarction iv) Diabetic nephropathy several days to 25 - 50 mg 3 times daily iii) Initially 6.25 stridor or angioedema of the face, tongue, or glottis exposure to ACE inhibitors. Hypersensitivity to diuretics. Antihypertensive effect diminished by
irritation and abdominal pain, leucopenia, cough
mg daily, gradually increased to 37.5 mg daily in is observed, aortic stenosis, breast feeding period, this or any other ACE inhibitor. Pregnancy indomethacin, salicylates, NSAIDs
divided doses iv) 75 - 100 mg daily in divided doses cough, impaired renal function (second and third trimester pregnancy)

Retinal disease; conjunctival or corneal damage. Ciliary spasm leads to headache and browache
Intraocular pressure and visual fields should be which may be more severe in the initial 2 - 4 Contraindicated in conditions where pupillary
monitored in those with simple chronic glaucoma weeks of treatment. Ocular side effects include constriction is undesirable such as acute iritis,
Instill no more than 1/2 ml gently into the anterior
Carbachol 0.01% Intraocular Solution Miostat For intraocular use for miosis during surgery and those receiving long-term treatment with a burning, itching, smarting, blurred vision, anterior uveitis and some forms of secondary Not known
chamber
miotic. Caution in cardiac disease, hypertension, conjunctival vascular congestion, myopia, lens glaucoma. Acute inflammatory disease of the
asthma, peptic ulceration, urinary-tract obstruction changes with chronic use, vitreous anterior segment
and parkinson's disease haemorrhage, and pupillary block

Rash, Stevens-Johnson Syndrome, nausea,


ADULT: Initially, 100-200 mg once or twice daily drowsiness, dizziness, ataxia, blood dyscrasias,
Breast feeding, pregnancy, liver or kidney Plasma level is increased by erythromycin,
gradually increased by increments of 100-200 mg every confusion, agitation, visual disturbance,
dysfunction, increased intraocular pressure, history diltiazem, isoniazid, verapamil, fluoxetine,
2 week. Maintenance: 0.8-1.2 g daily in divided doses. constipation or diarrhoea, anorexia, leukopenia,
of cardiac damage, elderly patients, glaucoma, may Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
Carbamazepine 100 mg/5 ml (2% CHILD: 10-15 years: 0.6-1 g daily; 5-10 years: 400-600 blood disorders, Syndrome of inappropriate ADH
Tegretol Epilepsy exacerbate certain types of idiopathic epilepsy. tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
w/v) Syrup mg daily; 1-5 years: 200-400 mg daily; less than or (SIADH), cardiac conduction abnormalities,
Avoid abrupt discontinuation. Neonatal withdrawal porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
equal to 1 year: 100-200 mg daily. Alternatively, 10-20 gynaecomastia. Allergic skin reactions,
syndrome. Potential for an increase in risk of suicidal muscle relaxants. Cytochrome P450 3A4
mg/kg body weight daily in divided doses. Max: Adult: leukopenia, vomiting, accommodation disorders,
thoughts or behaviours inducers or inhibitors, oral contraceptive
1.6 g daily diplopia, raised liver enzymes, thrombocytopenia
and hyponatraemia, exfoliative dermatitis

Breast feeding, pregnancy, liver or kidney


dysfunction, increased intraocular pressure, history Rash, Stevens-Johnson Syndrome, nausea,
of cardiac damage, elderly patients, glaucoma, may drowsiness, dizziness, ataxia, blood dyscrasias,
Plasma level is increased by erythromycin,
ADULT: Initial, 200 mg twice daily for the first week, exacerbate certain types of idiopathic epilepsy. Initial confusion, agitation, visual disturbance,
diltiazem, isoniazid, verapamil, fluoxetine,
may increase dosage by 200 mg/day at weekly and periodic complete blood counts, liver function constipation or diarrhoea, anorexia, leukopenia,
Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
intervals until optimal response is obtained. Maximum tests and urinalysis. Monitor plasma levels. History blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 200 mg CR Tablet Tegretol CR Epilepsy tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
1.6 g/day. CHILD: usual maximum dosage 1000 haematological reactions. Road/machinery users. (SIADH), cardiac conduction abnormalities,
porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
mg/day in children 12-15 years of age, 1200 mg/day in Increased intraocular pressure, latent psychosis, gynaecomastia. Allergic skin reactions,
muscle relaxants. Cytochrome P450 3A4
patients above 15 years of age confusion, agitation. Mixed seizure disorders. leukopenia, vomiting, accommodation disorders,
inducers or inhibitors, oral contraceptive
Elderly. Avoid abrupt discontinuation. Neonatal diplopia, raised liver enzymes, thrombocytopenia
withdrawal syndrome. Potential for an increase in and hyponatraemia, exfoliative dermatitis
risk of suicidal thoughts or behaviours

Rash, Stevens-Johnson Syndrome, nausea,


i) ADULT: 100 - 200 mg 1 - 3 times daily increased drowsiness, dizziness, ataxia, blood dyscrasias,
Breast feeding, pregnancy, liver or kidney Plasma level is increased by erythromycin,
gradually to usual dose of 0.8 - 1.2 g daily in divided confusion, agitation, visual disturbance,
dysfunction, increased intraocular pressure, history diltiazem, isoniazid, verapamil, fluoxetine,
doses. CHILD: Up to 1 year: 100 - 200 mg daily; 1 - 5 constipation or diarrhoea, anorexia, leukopenia,
of cardiac damage, elderly patients, glaucoma, may Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
yrs: 200 - 400 mg daily; 5 - 10 years: 400 - 600 mg blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 200 mg Tablet Tegretol i) Epilepsy ii) Trigeminal neuralgia exacerbate certain types of idiopathic epilepsy. tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
daily; 10 - 15 years: 0.6 - 1 g daily ii) ADULT: Initially, (SIADH), cardiac conduction abnormalities,
Avoid abrupt discontinuation. Neonatal withdrawal porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
100 mg once or twice daily gradually increased as gynaecomastia. Allergic skin reactions,
syndrome. Potential for an increase in risk of suicidal muscle relaxants. Cytochrome P450 3A4
necessary. Maintenance: 400-800 mg daily in 2-4 leukopenia, vomiting, accommodation disorders,
thoughts or behaviours inducers or inhibitors, oral contraceptive
divided doses. Max: 1.2 g daily diplopia, raised liver enzymes, thrombocytopenia
and hyponatraemia, exfoliative dermatitis
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Breast feeding, pregnancy, liver or kidney
dysfunction, increased intraocular pressure, history Rash, Stevens-Johnson Syndrome, nausea,
of cardiac damage, elderly patients, glaucoma, may drowsiness, dizziness, ataxia, blood dyscrasias,
Plasma level is increased by erythromycin,
ADULT: Initial, 200 mg twice daily for the first week, exacerbate certain types of idiopathic epilepsy. Initial confusion, agitation, visual disturbance,
diltiazem, isoniazid, verapamil, fluoxetine,
may increase dosage by 200 mg/day at weekly and periodic complete blood counts, liver function constipation or diarrhoea, anorexia, leukopenia,
Hypersensitivity to carbamazepine products or cimetidine and decreased by other antiepileptics
intervals until optimal response is obtained. Maximum tests and urinalysis. Monitor plasma levels. History blood disorders, Syndrome of Inappropriate ADH
Carbamazepine 400 mg CR Tablet Tegretol CR Epilepsy tricyclic compounds, bone marrow suppression, and theophylline. May reduce alcohol tolerance
1.6 g/day. CHILD: usual maximum dosage 1000 haematological reactions. Road/machinery users. (SIADH), cardiac conduction abnormalities,
porphyria. Concomitant MAOIs, pregnancy and antagonise the effects of non-depolarising
mg/day in children 12-15 years of age, 1200 mg/day in Increased intraocular pressure, latent psychosis, gynaecomastia. Allergic skin reactions,
muscle relaxants. Cytochrome P450 3A4
patients above 15 years of age confusion, agitation. Mixed seizure disorders. leukopenia, vomiting, accommodation disorders,
inducers or inhibitors, oral contraceptive
Elderly. Avoid abrupt discontinuation. Neonatal diplopia, raised liver enzymes, thrombocytopenia
withdrawal syndrome. Potential for an increase in and hyponatraemia, exfoliative dermatitis
risk of suicidal thoughts or behaviours
Avoid contact with eyes, discontinue use if oral
Contact irritant dermatitis, infantile eczemas, acute and Apply sparingly and rub into affected area 2 - 3 times inflammation persists or worsens. Use with caution
Carbamide (Urea) 10 % Cream Calmurid Skin irritation, rash and ischaemic skin necrosis Hypersensitivity to urea or any component Not known
chronic allergic eczemas, icthyosis, hyperkeratotic daily and when required after cleansing skin on inflammed skin or exudative lesions: irritation may
results
Nausea, vomiting, abdominal pain, pruritus,
Prevention of uterine atony and postpartum Given by IV 100 mcg as a single dose as soon as flushing, feeling of warmth, hypotension,
Hyponatraemia, cardiovascular disease (avoid if Pre-eclampsia and eclampsia, epilepsy, hepatic Vasoconstrictors in conjunction with caudal block
Carbetocin 100 mcg/ ml Injection Duratocin hemorrhage following elective cesarean section under possible after delivery, preferably before removal of headache, tremor, back pain, dizziness, metallic
severe), migraine, asthma impairment, renal impairment anaesthesia, cyclopropane anaesthesia
epidural or spinal anaesthesia placenta taste, anaemia, sweating, chest pain, dyspnoea,
chills, tachycardia, anxiety
Concurrent use of digoxin and carbimazole may
May be given to pregnant women. Treatment result in decreased peak serum levels of digoxin.
ADULT: Initially 10 - 60 mg daily in divided doses. Nausea, mild gastrointestinal disturbance, should be discontinued 3 - 4 weeks before Antithyroid drugs, by reducing the extent of
Carbimazole 5 mg Tablet Neo-mercazole Hyperthyroidism Liver disorders, pregnancy, breast feeding
Maintenance: 5 - 20 mg daily rashes, bone marrow supression delivery. Infants should not breast fed by hyperthyroidism, decrease the metabolism of
mothers taking carbimazole clotting factors and thus reduce the effects of
oral anticoagulants
360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1
hour on Day 1 every 4 weeks. Alternatively, Myelosuppression, renal impairment. Monitor blood Nephrotoxic and ototoxic drugs, phenytoin. If
Myelosuppression, alopecia, mucositis, Hypersensitivity to cisplatin/ platinum products or
Adult solid tumours, paediatric tumours. Salvage prescription may be based on Area Under Curve (AUC) counts and renal function. Do not use infusion sets platinum compound is used with taxane, to be
Carboplatin 150 mg Injection Paraplatin electrolyte disturbances, nausea and vomiting, mannitol, pregnancy, lactation, severe
therapy for lymphoma calculations. CHILD: 500-600 mg/m2 over 1 hour once or needles containing aluminium, avoid given after taxane. Increased risk of infection by
nephrotoxicity, ototoxicity, peripheral neuropathy myelosuppression
every 3 weeks. Salvage regimes in lymphomas - refer extravasation live vaccines, zidovudine
to specific protocols
360 - 400 mg/m2 BSA, by IV infusion over 15 mins to 1
hour on Day 1 every 4 weeks. Alternatively, Myelosuppression, renal impairment. Monitor blood Nephrotoxic and ototoxic drugs, phenytoin. If
Myelosuppression, alopecia, mucositis, Hypersensitivity to cisplatin/ platinum products or
Adult solid tumours, paediatric tumours. Salvage prescription may be based on Area Under Curve (AUC) counts and renal function. Do not use infusion sets platinum compound is used with taxane, to be
Carboplatin 450 mg Injection Paraplatin electrolyte disturbances, nausea and vomiting, mannitol, pregnancy, lactation, severe
therapy for lymphoma calculations. CHILD: 500-600 mg/m2 over 1 hour once or needles containing aluminium, avoid given after taxane. Increased risk of infection by
nephrotoxicity, ototoxicity, peripheral neuropathy myelosuppression
every 3 weeks. Salvage regimes in lymphomas - refer extravasation live vaccines, zidovudine
to specific protocols
Glaucoma, elevated intraocular pressure, asthma or
history of asthma. Cephalopevic relationships
carefully evaluated prior to use. During use, uterine
ADULT: by deep IM injection; 250 mcg, may repeat at
activity, foetal status and the progression of cervical Nausea, vomiting and diarrhoea, paraesthesia,
15-90 minute, intervals to a total dose of 2 mg (8 Hypersensitivity to prostagladin, acute pelvic
Carboprost Tromethamine 250 mcg dilation evaluated at frequent intervals. In patients fever or chills, dystonia, breast tenderness,
Hemabate Postpartum haemorrhage refractory to oxytocin doses), followed by subsequent doses of 250 mcg at inflammatory disease, cardiac, renal, pulmonary Not known
Injection with history of hypertonic uterine contractility or hyperthermia and flushing, bronchospasm,
intervals of 1.5 to 3.5 hours. Dosage may be increased or hepatic disease
tetanic uterine contractions, recommended that cardiovascular collapse
to 500 mcg/dose if contractility is inadequate
uterine activity and state of foetus be monitored
throughout labour. Possible uterine rupture where
high tone myometrical contractions are sustained

Myocardial temperature should be monitored during


surgery to maintain hypothermia. Continuous
Dilute 20 ml to 1 L of Ringer solution (cooled to 2-8 °C
electrocardiogram monitoring is essential to detect
Cardioplegia solution containing prior to use). Initial rapid instillation into aortic root at Myocardial infarction, electrocardiographic Incompatible with aminophylline, barbiturates,
For myocardial preservation(prevent myocardial changes in myocardial activity during the procedure.
Potassium Chloride, Magnesium - 300 ml/m² body surface area/min for 3 minutes. Should abnormalities and arrhythmias including Not for intravenous injection magnesium sulphate, phenytoin sodium, sodium
damage) during cardiac surgery Appropriate equipment to defibrillate the heart
chloride & Procaine HCl Injection myocardial activity persist or recur instill at 300ml/m² ventricular fibrillation bicarbonate, amikacin, amphotericin, dobutamine
following cardioplegia should be readily available.
body surface area/min for 2 minutes
Inotropic support drugs should be available during
postoperative recovery
Hypotensive effects potentiated by adrenergic
Hypersensitivity to carvedilol, asthma, neurone-blocking drugs, catecholamine
3.125 mg twice daily for 2 weeks, then 6.25 mg twice Avoid abrupt withdrawal, gradual withdrawal over a
bradycardia, 2nd and 3rd degree AV block, depletors, central nervous system depressants,
Treatment of stable moderate to severe congestive daily for 2 weeks, then 12.5 mg twice daily for 2 weeks period of 1 to 2 weeks is recommended. Dizziness, headache, tiredness, gastrointestinal
Carvedilol 25 mg Tablet Dilatrend cardiogenic shock overt cardiac failure, diuretics and vasodilators. Action decreased by
cardiac failure in addition to ACEI's and diuretics then 25 mg twice daily (titrated up to the highest Bronchospastic disease, congestive heart failure, disorders, flu-like symptoms
obstructive airway disease, severe chronic heart rifampicin. Concurrent administration with
tolerated level) diabetes mellitus
failure and hepatic impairment cardiac glycosides may cause a sharp drop in
heart rate
Hypotensive effects potentiated by adrenergic
Hypersensitivity to carvedilol, asthma, neurone-blocking drugs, catecholamine
3.125 mg twice daily for 2 weeks, then 6.25 mg twice Avoid abrupt withdrawal, gradual withdrawal over a
bradycardia, 2nd and 3rd degree AV block, depletors, central nervous system depressants,
Treatment of stable moderate to severe congestive daily for 2 weeks, then 12.5 mg twice daily for 2 weeks period of 1 to 2 weeks is recommended. Dizziness, headache, tiredness, gastrointestinal
Carvedilol 6.25 mg Tablet Dilatrend cardiogenic shock overt cardiac failure, diuretics and vasodilators. Action decreased by
cardiac failure in addition to ACEI's and diuretics then 25 mg twice daily (titrated up to the highest Bronchospastic disease, congestive heart failure, disorders, flu-like symptoms
obstructive airway disease, severe chronic heart rifampicin. Concurrent administration with
tolerated level) diabetes mellitus
failure and hepatic impairment cardiac glycosides may cause a sharp drop in
heart rate
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
Invasive aspergillosis & invasive candidiasis: ADULT:
Concomitant ciclosporine; use only if benefits Fever, nausea, vomiting, flushing, rash,
Initially, 70 mg infused over 1 hour followed by Tacrolimus, cyclosporine, inducer of drug
Confirmed systemic fungal infection in patients who are outweigh risk of possible hepatic toxicity, liver dyspnoea, dystonia, facial swelling, pruritus,
Caspofungin Acetate 50 mg Injection Cancidas subsequent doses of 50 mg/day. Oesophageal Hypersensitivity to caspofungin acetate clearance (e.g. efavirenz, nevirapine, rifampicin,
refractory or intolerant to other fungal therapies impairment, myelosuppression, pregnancy, lactation, increased liver enzymes, complication of
candidiasis: ADULT: 50 mg by slow IV infusion over dexamethasone, phenytoin, carbamazepine)
renal insufficiency infusion, thrombophlebitis, headache
approximately 1 hour
Invasive aspergillosis & invasive candidiasis: ADULT:
Concomitant ciclosporine; use only if benefits Fever, nausea, vomiting, flushing, rash,
Initially, 70 mg infused over 1 hour followed by Tacrolimus, cyclosporine, inducer of drug
Confirmed systemic fungal infection in patients who are outweigh risk of possible hepatic toxicity, liver dyspnoea, dystonia, facial swelling, pruritus,
Caspofungin Acetate 70 mg Injection Cancidas subsequent doses of 50 mg/day. Oesophageal Hypersensitivity to caspofungin acetate clearance (e.g. efavirenz, nevirapine, rifampicin,
refractory or intolerant to other fungal therapies impairment, myelosuppression, pregnancy, lactation, increased liver enzymes, complication of
candidiasis: ADULT: 50 mg by slow IV infusion over dexamethasone, phenytoin, carbamazepine)
renal insufficiency infusion, thrombophlebitis, headache
approximately 1 hour
Infections caused by susceptible organisms including
Probenecid, oral anticoagulants, bacteriostatic
Staphylococcus aureus and H. influenzae, treatment of 20 - 40 mg/kg body weight daily in 3 divided doses. Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 125 mg/5 ml Suspension Ceclor, Distaclor Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
sinusitis and infections involving the respiratory tract, Maximum: 1 g daily impaired renal function allergic skin reactions
effectiveness
skin and skin structure, bone and joint, and urinary tract
i) 375 mg twice daily ii) 375 mg or 500 mg twice daily iii) Probenecid, oral anticoagulants, bacteriostatic
i) Adult pharyngitis, tonsillitis, skin& soft tissue Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 375 mg MR Tablet Distaclor 750mg twice daily iv) 375mg twice daily or 500 mg Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
infections ii) Bronchitis iii) Pneumonia iv) Lower UTI impaired renal function allergic skin reactions
once daily effectiveness
Infections caused by susceptible organisms including ADULT: 250 mg 3 times daily for 10 days. For severe
Probenecid, oral anticoagulants, bacteriostatic
Staphylococcus aureus and H. influenzae, treatment of infections, double the dosage. Maximum: 4 g daily. Penicillin-sensitive patients, history of GI disease, Blood disorders, GI disturbances, CNS effects,
Cefaclor 500 mg Capsule Ceclor, Distaclor Hypersensitivity to cephalosporins antibiotics may reduce cephalosporin
sinusitis and infections involving the respiratory tract, CHILD: 20 - 40 mg/kg body weight daily in 3 divided impaired renal function allergic skin reactions
effectiveness
skin and skin structure, bone and joint, and urinary tract doses. Maximum: 1 g daily

Drug induced fever, reddening of skin with heat


Infection caused by cefazolin-sensitive microorganism, ADULT: Uncomplicated infections: 500 - 1000 mg 2 - 3 sensation, angioneurotic edema, itch, Steven
infection of the respiratory tract, urogenital tract, skin times daily. Moderately severe and severe infections: Allergic, diathesis with bronchial asthma or hay Johnson Syndrome, urticaria, eosinophilia,
Cefazolin Sodium 1 g Injection Cefazolin Sandoz and soft tissue, bile duct, bones and joint, endocarditis, 500 - 1000 mg 3 - 4 times daily. Severe life-threatening fever, history of GI disease, renal impairment, allergic nephritis, GI disturbances, anaphylactic Hypersensitivity to cephalosporins Warfarin, probenecid
systemic septic infection, peri-operative/ surgical infections: 1 - 1.5 g 4 times daily. Rarely, dose up to 12 pregnancy and lactation reactions. Pseudomembranous enterocolitis,
prophylaxis g daily leukopenia, thrombocytopenia, neutropenia and
hepatotoxicity
Febrile neutropenia, septicaemia, lower respiratory
ADULT: 1 - 2 g twice daily for most infections. For Hypensensitivity, pseudomembranous colitis& GI disturbances (diarrhoea, nausea, vomiting),
tract infection, urinary tract infection, skin and skin Hypersensitivity to cephalosporins, penicillins or
Cefepime 1 g Injection Maxipime severe infections including febrile neutropenia: 2 g 3 superinfection may occur. Discontinue therapy if history of colitis, hypersensitivity, respiratory and Typhoid vaccine
structure infections, gynaecologic and intra-abdominal other beta-lactam antibiotics
times daily. CHILD: 25 - 50 mg/kg 3 times daily allergic reaction occurs. Pregnancy, lactation CNS disorders including headache, vaginitis
infections
Febrile neutropenia, septicaemia, lower respiratory
ADULT: 1 - 2 g twice daily for most infections. For Hypensensitivity, pseudomembranous colitis& GI disturbances (diarrhoea, nausea, vomiting),
tract infection, urinary tract infection, skin and skin Hypersensitivity to cephalosporins, penicillins or
Cefepime 500 mg Injection Maxipime severe infections including febrile neutropenia: 2 g 3 superinfection may occur. Discontinue therapy if history of colitis, hypersensitivity, respiratory and Typhoid vaccine
structure infections, gynaecologic and intra-abdominal other beta-lactam antibiotics
times daily. CHILD: 25 - 50 mg/kg 3 times daily allergic reaction occurs. Pregnancy, lactation CNS disorders including headache, vaginitis
infections
ADULT: 1 - 2 g twice daily IM or IV. By IV, adult dose
Hypersensitivity reactions eg. rash, urticaria,
may be doubled. Maximum: 16 g daily in divided doses. Penicillin-sensitive patients, severe biliary
fever, neutropenia (reversible),
Cefoperazone Sodium 1 g Injection Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
hypothrombinaemia, GI effects & local reactions,
doses. NEONATE less than 8 days: 50 - 200 mg/kg/day renal dysfunction
vitamin K deficiency
12 hourly
ADULT: 1 - 2 g twice daily IM or IV. By IV, adult dose
Hypersensitivity reactions eg. rash, urticaria,
may be doubled. Maximum: 16 g daily in divided doses. Penicillin-sensitive patients, severe biliary
fever, neutropenia (reversible),
Cefoperazone Sodium 2 g Injection Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
hypothrombinaemia, GI effects & local reactions,
doses. NEONATE less than 8 days: 50 - 200 mg/kg/day renal dysfunction
vitamin K deficiency
12 hourly
i) Treatment of infections due to multi-drug resistance Hepatic dysfunction& concomitant renal impairment,
Cefoperazone Sodium 500 mg & Diarrhoea, nausea, vomiting, maculopapular Known allergy to penicillins, sulbactam or
Sulperazon pathogens producing B-lactamase ii) Treatment of ADULT: 1 - 2 g twice daily. CHILD: 40 - 80 mg/kg/day ingestion of alcoholic beverages; overgrowth of Heparin, typhoid vaccine, warfarin
Sulbactam Sodium 500 mg Injection rash, urticaria; eosinophilia; drug fever cephalosporins
infections caused by Acinetobacter species nonsusceptible organisms
ADULT: 1 - 2 g twice daily IM or IV. By IV, adult dose
Hypersensitivity reactions eg. rash, urticaria,
may be doubled. Maximum: 16 g daily in divided doses. Penicillin-sensitive patients, severe biliary
Cefoperazone Sodium 500 mg fever, neutropenia (reversible),
Cefobid Infections due to gram-negative bacteria CHILD & INFANT: 50 - 200 mg/kg/day in 2 - 4 divided obstruction, severe hepatic disease or coexisting Hypersensitvity to cephalosporins Heparin, typhoid vaccine, warfarin
Injection hypothrombinaemia, GI effects & local reactions,
doses. NEONATE less than 8 days: 50 - 200 mg/kg/day renal dysfunction
vitamin K deficiency
12 hourly
Rash, pruritus, diarrhoea, nausea, vomiting,
Hypersensitivity to penicillins, history of
ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). colitis, thrombocytopenia, eosinophilia,
Cefotaxime 1 g Injection Claforan Infections due to gram-negative bacteria gastrointestinal disease especially colitis, pregnancy Hypersensitivity to cephalosporins Aminoglycosides, probenecid, typhoid vaccine
CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses leucopenia, hypersensitivity reactions, GI effects,
& lactation
anaphylactic shock(rare)
Rash, pruritus, diarrhoea, nausea, vomiting,
Hypersensitivity to penicillins, history of
ADULT: 1 g 12 hourly (up to 12 g/day in severe cases). colitis, thrombocytopenia, eosinophilia,
Cefotaxime 500 mg Injection Claforan Infections due to gram-negative bacteria gastrointestinal disease especially colitis, pregnancy Hypersensitivity to cephalosporins Aminoglycosides, probenecid, typhoid vaccine
CHILD: 50 - 180 mg/kg/day in 4 - 6 divided doses leucopenia, hypersensitivity reactions, GI effects,
& lactation
anaphylactic shock(rare)
GI upsets, CNS effects, phlebitis or
ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe thrombophlebitis at the IV injection site, pain
Aminoglycosides, probenecid, chloramphenicol,
Ceftazidime 1 g Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
live typhoid vaccine
- 3 divided doses hypersensitivity reactions. Transient
haematologicals changes
GI upsets, CNS effects, phlebitis or
ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe thrombophlebitis at the IV injection site, pain
Aminoglycosides, probenecid, chloramphenicol,
Ceftazidime 2 g Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
live typhoid vaccine
- 3 divided doses hypersensitivity reactions. Transient
haematologicals changes
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
GI upsets, CNS effects, phlebitis or
ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe thrombophlebitis at the IV injection site, pain
Aminoglycosides, probenecid, chloramphenicol,
Ceftazidime 250 mg Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
live typhoid vaccine
- 3 divided doses hypersensitivity reactions. Transient
haematologicals changes
GI upsets, CNS effects, phlebitis or
ADULT: 1 g 8 hourly or 2 g 12 hourly. In severe thrombophlebitis at the IV injection site, pain
Aminoglycosides, probenecid, chloramphenicol,
Ceftazidime 500 mg Injection Fortum Severe gram negative bacterial infections infections: 2 g 8 hourly. CHILD: 25 - 150 mg/kg/day in 2 Hypersensitivity to penicillins, renal impairment and/or inflammation after IM injection, very rarely Hypersensitivity to cephalosporins
live typhoid vaccine
- 3 divided doses hypersensitivity reactions. Transient
haematologicals changes
Previous hypersensitivity to penicillins, anaphylactic
shock, severe renal& hepatic failure, pregnancy.
Ceftriaxone and calcium -containing solutions may
be administered sequentially to one another if the
infusion lines are thoroughly flushed between
Hypersensitivity to cephalosporins. Neonates
infusions with compatible fluid. Diluents containing
aged less than or 28 days if they require
calcium (Ringer's / Hartmann's solution) are not to GI upsets, haematological changes, skin
i) 250 mg by deep IM injection ii) single IM injection 250 treatment with calcium-containing intravenous
Ceftriaxone 0.25 g Injection Rocephin i) Gonorrhoea ii) Chancroid be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
mg only. For severe infection up to 100 mg/kg/day solutions, including calcium-containing infusions
dilute a reconstituted vial for IV administration agranulocytosis, renal precipitations
such as parenteral nutrition, because of the risk
because a precipitate can form. Ceftriaxone must not
of precipitation of ceftriaxone-calcium
be administered simultaneously with calcium-
containing intravenous solutions, including continous
calcium -containing infusions such as parenteral
nutrition via a Y-site, because precipaitation of
ceftriaxone-calcium can occur
Previous hypersensitivity to penicillins, anaphylactic
shock, severe renal& hepatic failure, pregnancy.
Ceftriaxone and calcium -containing solutions may
be administered sequentially to one another if the
infusion lines are thoroughly flushed between
ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at Hypersensitivity to cephalosporins. Neonates
infusions with compatible fluid. Diluents containing
12 hour intervals. INFANT & CHILD, 3 weeks - 12 aged less than or 28 days if they require
calcium (Ringer's / Hartmann's solution) are not to GI upsets, haematological changes, skin
years: 20 - 80 mg/kg body weight daily. CHILD with treatment with calcium-containing intravenous
Ceftriaxone 0.5 g Injection Rocephin Infections caused by susceptible organisms be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
body weight 50 kg or more: adult dose. NEONATE up solutions, including calcium-containing infusions
dilute a reconstituted vial for IV administration agranulocytosis, renal precipitations
to 2 weeks: 20 - 50 mg/kg body weight daily, not to such as parenteral nutrition, because of the risk
because a precipitate can form. Ceftriaxone must not
exceed 50 mg/kg of precipitation of ceftriaxone-calcium
be administered simultaneously with calcium-
containing intravenous solutions, including continous
calcium -containing infusions such as parenteral
nutrition via a Y-site, because precipaitation of
ceftriaxone-calcium can occur
Previous hypersensitivity to penicillins, anaphylactic
shock, severe renal& hepatic failure, pregnancy.
Ceftriaxone and calcium -containing solutions may
be administered sequentially to one another if the
infusion lines are thoroughly flushed between
ADULT: 1 - 2 g once daily. Severe infection: 4 g daily at Hypersensitivity to cephalosporins. Neonates
infusions with compatible fluid. Diluents containing
12 hour intervals. INFANT & CHILD, 3 weeks - 12 aged less than or 28 days if they require
calcium (Ringer's / Hartmann's solution) are not to GI upsets, haematological changes, skin
years: 20 - 80 mg/kg body weight daily. CHILD with treatment with calcium-containing intravenous
Ceftriaxone 1g Injection Rocephin Infections caused by susceptible organisms be used to reconstitute ceftriaxonevials or to further reactions, coagulation disorders, phlebitis, Ciclosporin, typhoid vaccine
body weight 50 kg or more: adult dose. NEONATE up solutions, including calcium-containing infusions
dilute a reconstituted vial for IV administration agranulocytosis, renal precipitations
to 2 weeks: 20 - 50 mg/kg body weight daily, not to such as parenteral nutrition, because of the risk
because a precipitate can form. Ceftriaxone must not
exceed 50 mg/kg of precipitation of ceftriaxone-calcium
be administered simultaneously with calcium-
containing intravenous solutions, including continous
calcium -containing infusions such as parenteral
nutrition via a Y-site, because precipaitation of
ceftriaxone-calcium can occur
GI disturbances occasionally
Upper respiratory tract, GUT, skin & soft tissue ADULT: 250 mg twice daily ;UTI: 125 mg twice daily.
Cefuroxime Axetil 125 mg Tablet Zinnat Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
infections, urinary tract infection (UTI), pyelonephritis CHILD:125 mg twice daily. Maximum 250 mg/day
reactions, eosinophilia, headache, superinfection

GI disturbances occasionally
Cefuroxime Axetil 125 mg/5 ml
Zinnat Infections caused by susceptible organisms 30 mg/kg/day in 2 divided doses Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
Suspension
reactions, eosinophilia, headache, superinfection

GI disturbances occasionally
Upper respiratory tract, GUT, skin & soft tissue ADULT: 250 mg twice daily ;UTI: 125 mg twice daily.
Cefuroxime Axetil 250 mg Tablet Zinnat Anaphylactic reaction to penicillins pseudomembraneous colitis, hypersensitivity Hypersensitivity to cephalosporins Aminoglycosides, typhoid vaccine
infections, urinary tract infection (UTI), pyelonephritis CHILD:125 mg twice daily. Maximum 250 mg/day
reactions, eosinophilia, headache, superinfection
ADULT: 750 mg 6 - 8 hours IM or IV. Severe infections: Hypersensitivity, GI disturbances including
Infections caused by susceptible organisms, surgical 1.5 g three times to four times daily IV. CHILD: 30 - 100 Anaphylactic reaction to penicillins, concurrent pseudomembraneous colitis, haematological Probenecid, aminoglycosides, live typhoid
Cefuroxime Sodium 1.5 g Injection Zinacef Hypersensitivity to cephalosporins
prophylaxis mg/kg/day in 3 - 4 divided doses. Surgical prophylaxis: treatment with potent diuretics. Renal impairment changes, superinfection, transient pain at IM vaccine
1.5 g IV injection site, thrombophlebitis (IV injection)
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions
ADULT: 750 mg 6 - 8 hours IM or IV. Severe infections: Hypersensitivity, GI disturbances including
Infections caused by susceptible organisms, surgical 1.5 g three times to four times daily IV. CHILD: 30 - 100 Anaphylactic reaction to penicillins, concurrent pseudomembraneous colitis, haematological Probenecid, aminoglycosides, live typhoid
Cefuroxime Sodium 250 mg Injection Zinacef Hypersensitivity to cephalosporins
prophylaxis mg/kg/day in 3 - 4 divided doses. Surgical prophylaxis: treatment with potent diuretics. Renal impairment changes, superinfection, transient pain at IM vaccine
1.5 g IV injection site, thrombophlebitis (IV injection)
ADULT: 750 mg 6 - 8 hours IM or IV. Severe infections: Hypersensitivity, GI disturbances including
Infections caused by susceptible organisms, surgical 1.5 g three times to four times daily IV. CHILD: 30 - 100 Anaphylactic reaction to penicillins, concurrent pseudomembraneous colitis, haematological Probenecid, aminoglycosides, live typhoid
Cefuroxime Sodium 750 mg Injection Zinacef Hypersensitivity to cephalosporins
prophylaxis mg/kg/day in 3 - 4 divided doses. Surgical prophylaxis: treatment with potent diuretics. Renal impairment changes, superinfection, transient pain at IM vaccine
1.5 g IV injection site, thrombophlebitis (IV injection)
i) ADULTS: 200 mg once daily. CHILD not
recommended ii) 100mg twice daily, increased if GI disorders, flatulence, insomnia, pharyngitis,
necessary to 200 mg 2 times daily; CHILD not sinusitis, dizziness, vertigo, hearing disturbance,
recommended iii) 400mg as a single dose on first day Hypertension, cardiac conditions, liver/renal photosensitivity, blood disorder, fluid retention, Hypersensitivity to celecoxib, allergic-type
Diuretics, anti-coagulants, sulphonylureas,
i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain followed by 200mg once daily on subsequent days iv) dysfunction, elderly, fluid retention, children, renal failure, hepatic impairment, Steven- reaction to sulphonamides, aspirin or other
Celecoxib 200 mg Capsule Celebrex captopril, phenytoin, digoxin, fluconazole, lithium,
iv) Ankylosing Spondylitis Initial, 200 mg once daily or 100 mg twice daily; if no asthmatic, coagulation defects, pregnancy (third Johnson syndrome, allergic reactions, chest nonsteroidal anti-inflammatory agents, ischaemic
antacids, aspirin, glucocorticoids, warfarin
effect after 6 weeks, may increase to max. 400 mg daily trimester) pain, oedema, hot flushes, flu-like symptoms. heart disease and stroke patient
in 1-2 divided doses. If no response following 2 weeks Gastric side effects are lesser with this drug as
of treatment with 400 mg/day, consider discontinuation compared to other NSAIDs.
and alternative treatment
i) ADULTS: 200 mg once daily. CHILD not
recommended ii) 100 mg twice daily, increased if Gastrointestinal disorders, flatulence, insomnia,
necessary to 200 mg 2 times daily; CHILD not pharyngitis, sinusitis, dizziness, vertigo, hearing
recommended iii) 400 mg as a single dose on first day Hypertension, cardiac conditions, liver/renal disturbance, photosensitivity, blood disorder, Hypersensitivity to celecoxib, allergic-type
Diuretics, anti-coagulants, sulphonylureas,
i) Osteoarthritis ii) Rheumatoid Arthritis iii) Acute pain followed by 200 mg once daily on subsequent days iv) dysfunction, elderly, fluid retention, children, fluid retention, renal failure, hepatic impairment, reaction to sulphonamides, aspirin or other
Celecoxib 400 mg Capsule Celebrex® captopril, phenytoin, digoxin, fluconazole, lithium,
iv) Ankylosing Spondylitis Initial, 200 mg once daily or 100 mg twice daily; if no asthmatic, coagulation defects, pregnancy (third Steven-Johnson syndrome, allergic reactions, nonsteroidal anti-inflammatory agents, ischaemic
antacids, aspirin, glucocorticoids, warfarin
effect after 6 weeks, may increase to max. 400 mg daily trimester) chest pain, oedema, hot flushes, flu-like heart disease and stroke patient
in 1-2 divided doses. If no response following 2 weeks symptoms. Gastric side effects are lesser with
of treatment with 400 mg/day, consider discontinuation this drug as compared to other NSAIDs
and alternative treatment
Concurrent treatment with high doses of
Respiratory tract infections, ear, nose and throat GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 125 mg/5 ml CHILD: 25 - 100 mg/kg/day every 6 hourly. Maximum: 4 Hypersensitivity to penicillins, renal impairment,
Ceporex infections, urinary tract infections, obstetric and organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Syrup g daily superinfection
gynaecologic infections neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Concurrent treatment with high doses of
i) Respiratory tract infection, urinary tract infection ii) GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Capsule 3 times daily or 4 times daily. Maximum: 6 g/day superinfection
iii) Pneumonia neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Concurrent treatment with high doses of
i) Respiratory tract infection, urinary tract infection ii) GI disturbances; overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg ADULT: i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms; hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Tablet 1 - 1.5 g 3 - 4 times daily. Maximum: 6 g/day superinfection
iii) Pneumonia neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Concurrent treatment with high doses of
Respiratory tract infections, ear, nose and throat GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 250 mg/5 ml CHILD: 25 - 100 mg/kg/day every 6 hourly. Maximum: 4 Hypersensitivity to penicillins, renal impairment,
Ceporex infections, urinary tract infections, obstetric and organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Syrup g daily superinfection
gynaecologic infections neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Concurrent treatment with high doses of
i) Respiratory tract infection, urinary tract infection ii) GI disturbances, overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 500 mg i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) 1 - 1.5 g Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms, hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Capsule 3 times daily or 4 times daily. Maximum: 6 g/day superinfection
iii) Pneumonia neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Concurrent treatment with high doses of
i) Respiratory tract infection, urinary tract infection ii) GI disturbances; overgrowth of non-susceptible cephalosporins& aminoglycosides or potent
Cephalexin Monohydrate 500 mg ADULT: i) 250 mg 6 hourly ii) 250 - 500 mg 6 hourly iii) Hypersensitivity to penicillins, renal impairment,
Ceporex Complicated, recurrent or chronic infections, bronchitis organisms; hypersensitivity reactions, reversible Hypersensitivity to cephalosporins diuretics may adversely affect renal function.
Tablet 1 - 1.5 g 3 - 4 times daily. Maximum: 6 g/day superinfection
iii) Pneumonia neutropenia Probenecid may increase or prolong plasma
level& toxicity of cephalosporins
Activities requiring mental alertness. Concurrent use
ADULT and CHILD over 6 years:10 mg daily or 5 mg Decreased cetirizine clearance resulting in
Urticaria, allergic dermatoses (insect bites, atopic of central nervous system depressants. Renal
Cetirizine HCl 10 mg Tablet Zyrtec twice daily. Child 2-6 years: 5 mg once daily or 2.5 mg Somnolence, fatigue, headache and dry mouth Hypersensitivity to cetirizine or hydroxyzine elevated cetirizine serum concentrations and
eczema), perennial rhinitis, allergic rhinitis insufficiency or hepatic dysfunction, elderly. Patient
twice daily possibly cetirizine toxicity with theophylline
less than 2 years
Contact with the eyes, brain, meninges, and middle
Hypersensitivity to cetrimide after prolonged and
Cetrimide 0.5% Cream Cetavlon As shampoo and cleanser Apply to affected area ear should be avoided. Cetrimide should not be used Hypersensitivity to cetrimide Not known
repeated applications
in body cavities or as an enema
Contact with the eyes, brain, meninges, and middle
Cetrimide 1-2% Lotion. Cetavlon As shampoo and cleansing agent Apply to affected area ear should be avoided. Cetrimide should not be used Cutaneous irritation and local effects Hypersensitivity to cetrimide Not known
in body cavities or as an enema
Prevention of premature ovulation in patients Given by SC 0.25 mg/day, given either in the morning
Active allergic conditions or a history of allergies, Mild and transient injection site reaction, nausea, Pregnancy and lactation, moderate to severe
undergoing a controlled ovarian stimulation, followed beginning on the day 5 or 6 of ovarian stimulation or in
Cetrorelix 0.25 mg Injection Cetrotide children. Not intended for use in elderly more than headache, ovarian hyperstimulation syndrome, renal or hepatic impairment, severe allergic Not known
by oocyte pick-up and assisted reproductive the evening beginning on day 5, and continued until
65 years rarely hypersensitivity reactions condition
techniques ovulation induction
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

i) ADULT 0.5-1 g given 3-4 times daily. CHILD half


adult dose. ii) Need to be dissolved in liquid (slurry
Acarbose, carbamazepine, digoxin, frusemide,
consistency). ADULT and CHILD over 12 years: initial
olanzapine, phenytoin; decreased effectiveness
30-100 g or 1-2 g/kg; repeat initial dose as soon as
i) Diarrhoea and food poisoning ii) Reduce absorption Aspiration of charcoal, hydrocarbons, corrosive, of these drugs, reduce absorption of oral therapy
possible or 20-50 g every 2-6 hours. CHILD over 1-12 An unprotected airway, gastrointestinal tract not
Charcoal, Activated 250 mg Tablet - of drugs, plant, inorganic poison and chemicals in imaging of gastroesophageal. Caution in patient at Black stools and gastrointestinal disturbances and render their effectiveness, simultaneous oral
years, 25-50 g or 1-2 g/kg; may repeat half the initial anatomically intact
poisoning cases risk of gastrointestinal obstruction therapy should be avoided. Clear activated
dose every 2-6 hour as needed. CHILD to 1 year of
charcoal from stomach /avoid its usage if
age, 1 g/kg; may repeat half the initial dose every 2-6
methionine (specific oral antidote) is to be used
hours as needed. For maximum efficacy administer
within 1 hour after ingestion of toxic compound
History of gastritis or duodenal ulcers, mentally Arrhythmias, hallucination, disorientation,
Warfarin, increased risk of bleeding. Frusemide,
depressed patients, severe cardiac disease, nausea, vomiting, diarrhoea, gastric irritation, Hypersensitivity to chloral hydrate products,
ADULT : 0.5 - 1 g (max 2 g) with plenty of water at cardiovascular toxicity (diaphoresis,
Chloral Hydrate 200 mg/5 ml Mixture - Preoperative sedation respiratory disease, lactation, acute intermitent vertigo, nightmares, delirium, flatulence, cardiac disease, hepatic or renal impairment,
bedtime. CHILD : 30 - 50 mg/kg up to a max dose of 1 g hypertension, tachycardia). Alcohol, increased
porphyria, skin/mucous membrane irritation, avoid abdominal distention, leucopenia, eosinophilia, pregnancy, breast feeding, porphyria, gastritis
sedation. May reduce effect of phenytoin
prolonged use and abrupt withdrawal ketonuria, respiratory depression, rashes
Myelosuppression, azoospermia/amenorrhoea,
Myelosuppression. Monitor blood counts. History of
rash, allergic reactions, seizures, nausea and
seizures. If generalised skin rash develops during
Low grade lymphoma, chronic lymphocytic leukaemia. vomiting, diarrhoea, stomatitis, interstitial Ciclosporin, phenobarbital, phenytoin,
Chlorambucil 2 mg Tablet Leukeran 200 mcg/kg body weight daily for 4 - 8 weeks treatment, to stop therapy to avoid progressing to Hypersensitivity to chlorambucil, pregnancy
Ovarian cancer pneumonitis, pulmonary fibrosis, transient allopurinol, live vaccines
erythema multiforme, toxic epidermal necrolysis or
elevation of liver enzymes, secondary
Stevens-Johnson syndrome
malignancies
Overgrowth of non-susceptible organisms in Allergic reactions, superinfection, bone marrow
Chloramphenicol 0.5% Eye Drops Chloromycetin Broad spectrum antibiotic in superficial eye infections 1 - 2 drops every 3 - 4 hours Hypersensitivity to chloramphenicol products Not known
prolonged use hypoplasia including aplastic anaemia
Apply 1/2 inch of ointment every 3 - 4 times into the Overgrowth of non-susceptible organisms in Allergic reactions, superinfection, bone marrow
Chloramphenicol 1% Eye Ointment Chloromycetin Conjunctivitis and other superficial eye infection Hypersensitivity to chloramphenicol products Not known
conjunctival sac prolonged use hypoplasia including aplastic anaemia
CHILD: 25 - 50 mg/kg/day in 4 divided doses. Severe Aplastic anaemia. Haemolytic anaemia in G6PD
Avoid prolong treatment or use in minor infections.
Chloramphenicol 125 mg/5 ml Typhoid fever, salmonella infections, meningitis, infections, premature& full-term infants less than 2 deficiency. Grey syndrome, bleeding, Bone marrow depressants, enhance effects of
Chloromycetin Liver impairment. Uraemic patients, infants, Hypersensitivity to chloramphenicol
Suspension cholera, anaerobic and rickettsial infections weeks: 25mg/kg/day in divided doses. Full-term infants peripheral& optic neuritis, hypersensitivity coumarin anticoagulants& warfarin, phenytoin
pregnancy, active immunisation
more than 2 weeks: up to 50mg/kg/day in divided doses reaction& erythema multiforme
Aplastic anaemia. Haemolytic anaemia in G6PD
ADULT: 500 mg 4 times daily or 50 mg/kg/day in 4 Avoid prolong treatment or use in minor infections. Bone marrow depressants, enhance effects of
Treatment of typhoid, paratyphoid fevers, deficiency. Grey syndrome, bleeding, peripheral
Chloramphenicol 250 mg Capsule Chloromycetin divided doses. Maximum dose: 4 g/day. CHILD: 25 - Liver impairment. Uraemic patients, infants, Hypersensitivity to chloramphenicol coumarin anticoagulants & warfarin, phenytoin &
bronchopneumonia and enteric infection & optic neuritis, hypersensitivity reaction&
100 mg/kg/day in 4 divided doses pregnancy, active immunisation some hypoglycaemic agents
erythema multiforme
Use with caution in the presence of perforated Sensitivity to the vehicle propylene glycol, local Hypersensitivity to chloramphenicol products,
Apply 2 - 3 drops into the ear 2 - 3 times daily. Not to be With other antibacterials, antiepileptics,
Chloramphenicol 5% w/v Ear Drops Chloromycetin Acute otitis media, otitis externa with perforation tymphanic membrane. Overgrowth of non- irritation with symptoms of burning, itching, perforated tympanic membrane, chronic otitis
used for long term anticoagulants, cyclosporin
susceptible infection over prolonged use urticaria, transient stinging media with perforation
Depression of bone marrow leading to Phenobarbitone& rifampicin may reduce the
ADULT: 1.5 - 3 g daily in divided doses every 6 hourly. Repeated courses& chronic treatment, infants, agranulocytosis, thrombocytopenia purpura, plasma concentration. Drugs which potentially
Chloramphenicol Sodium Succinate 1 Treatment of typhoid, paratyphoid fevers, Hypersensitivity, pregnancy and lactation,
Chloromycetin CHILD: 25 -100 mg/kg/day in divided doses every 6 impaired liver or kidney function. Frequent leucopenia and aplastic anaemia. Peripheral& depress bone marrow function. May potentiate
g Injection bronchopneumonia and enteric infection anaemia, porphyria
hourly haematological examination is recommended optic neuritis, erythema multiforme, GI disorders, actions of phenytoin, sulfonylureas&
urticaria, dry mouth and blurred vision anticoagulants

Avoid prolonged skin contact with alcoholic solution. Patients who have previously shown a
Chlorhexidine Gluconate 0.2 % Occasionally, irritative skin reactions, extremely
Hibitane As a gargle Rinse mouth with 10 ml for about 1 minute twice daily Avoid contact with eyes, brain, meninges, middle ear hypersensitivity reaction to chlorhexidine. Not known
Mouthwash rare, generalised allergic reactions
and body cavities. For external use only However, such reaction are extremely rare

Surgical hand disinfection: Apply 5ml to clean hands


Occasionally irritative skin reactions, generalised
and forearms for 1 min. Rinse and repeat with another
Surgical hand scrub/disinfection, pre-op skin For external use only. Avoid contact with eyes and allergic reactions, may cause gastrointestinal Hypersensitivity to chlorhexidine gluconate or
Chlorhexidine Gluconate 4% Scrub Hibiscrub 5ml for a further 2 mins and then rinse and dry. General Not known
preparation middle ear disturbances. Inhalation of solvent vapours may any component of the formulation
skin disinfection: Apply appropriate quantity to wet area
give rise to nausea, headaches and dizziness
and scrub for 1 min. Rinse thoroughly & dry
Mucosal irritation (discontinue if desquamation),
Avoid contact with meninges, application into hairy
parotid gland swelling, irritation and
i) Preoperative skin disinfection ii) Wounds or burns iii) areas and not use as a preoperative skin
Chlorhexidine Gluconate 5% Solution Hibitane i) & iii) 1 : 10 in 70 % Alcohol ii) 1 : 100 gastrointestinal disturbances. Inhalation of Hypersensitivity to any of its components Avoid cemented glass components
Emergency disinfection of instruments preparation for the face or head. Keep disinfectant
solvent vapours may give rise to nausea,
solution out of the eyes, ears and mouth
headaches and dizziness
Pre-op surgical hand disinfection: Spread 5ml throughly
over both hands and forearms, rubbing vigorously.
Incompatible with soaps and other anionic
When dry apply a further 5ml and repeat procedure. Avoid contact with eyes, brain meninges, body
Chlorhexidine Gluconate 5% Solution Occasionally irritative skin reactions, rare agents. Hypochlorite bleaches may cause brown
Antiseptic hand disinfection on the ward: Spread 3ml cavities, middle ear. Not for injection. Avoid Hypersensitivity to chlorhexidine gluconate or
1:10 in 70% alcohol with lanolin as Hibisol To be used undiluted for hand and skin disinfections generalised allergic reactions, dizziness, stains to develop in fabrics which have
throughly over the hands and wrist rubbing vigorously prolonged skin contact. Allow to dry before any component of the formulation
emollient confusion, headache or stupor previously been in contact with chlorhexidine
until dry. Disinfection of patient's skin: Prior to surgery, proceeding
solutions
apply to a sterile swab and rub thoroughly over the
operation site for a minimum of 2 mins
Irritating to skin, dissolves blood clots, delay
Chlorinated Lime Powder - Antiseptic and disinfectants Not applicable Bleaches fabric, irritant, do not use on open wounds Not known No interaction found
clotting
Chlorinated Lime Solution & Buffered Topically applied hypochlorites may dissolve blood Patients who have previously shown a
Eusol-T Wound or ulcer Apply to affected areas undiluted as a cleansing agent Skin irritation Not known
Acetate Solution clots and cause bleeding hypersensitivity reaction
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

ADULT 600 mg base stat, 300 mg 6 - 8 hours later and


a further 300 mg on each of 2 following days. CHILD 3 - May exacerbate psoriasis or trigger an acute attack Simultaneous use of corticosteroids can
Chloroquine Phosphate 250 mg Loss of appetite, nausea, pressure over the G6PD deficiency, diseases of haematopoietic
- Treatment of malaria - acute attack 4 years : 150 mg base stat, 75 mg 6 hours later, then of hepatic porphyria (metabolic abnormality). Pre- accentuate possible myopathies and
Tablet (150 mg Chloroquine base) stomach, visual disturbances organs or CNS, retinopathy
75 mg daily for 2 days. CHILD 5 - 8 years : 300 mg stat, existing kidney damage, first trimester of pregnancy cardiomyopathies
150 mg 6 hours later, then 150 mg daily for 2 days
Porphyria, pregnancy, asthma, glaucoma, avoid Drowsiness, dizziness, stinging or burning
10 - 20 mg IM or SC, repeated if required. Not to
Chlorpheniramine Maleate 10 mg/ml operating vehicles or machinery. Parenteral injection sensation at injection site, hypotension, CNS Alcohol pontentiate CNS depressants, actions
Piriton Allergic conditions exceed 40 mg in 24 hours. 10 - 20 mg over 1 minute by Hypersensitivity to chlorpheniramine
Injection have to be protected from light to prevent stimulation, tinnitus, blurred vision, irritability, prolonged by MOAIs, anticholigernic drugs
slow IV
discolouration lassitude
CHILD 1 - 2 years : 1 mg twice daily, 2 - 5 years : 1 mg Drowiness, dizziness, hypotension, CNS
Chlorpheniramine Maleate 2 mg/5 ml Symptomatic treatment of allergic conditions Porphyria, pregnancy, asthma, glaucoma, avoid Alcohol pontentiate CNS depressants, actions
Piriton every 4 - 6 hours (maximum 6 mg daily), 6 - 12 years : stimulation, tinnitus, blurred vision, irritability, Hypersensitivity to chlorpheniramine
Syrup responsive to antihistamine operating vehicles or machinery prolonged by MAOIs, anticholigernic drugs
2 mg every 4 - 6 hours (maximum 12 mg daily) lassitude

ADULT : 4 mg every 4 - 6 hours. Maximum 24 mg daily.


Drowsiness, dizziness, hypotension, CNS
Chlorpheniramine Maleate 4 mg Symptomatic treatment of allergic conditions CHILD 1 - 2 years : 1 mg twice daily, 2 - 5 years : 1 mg Prophyria, pregnancy, asthma, glaucoma avoid Alcohol, CNS depressants, MAOIs,
Piriton stimulation, tinnitus, blurred vision, irritability, Hypersensitivity to chlorpheniramine
Tablet responsive to antihistamines every 4 - 6 hours (maximum 6 mg daily), 6 - 12 years : operating vehicles or machinery anticholinergics drugs
lassitude
2 mg every 4 - 6 hours (maximum 12 mg daily)

Postural hypotension, akathisia, tardive


dyskinesia, arrhythmias, constipation, Alcohol, CNS depressant, anticholinergic,
Pregnancy and lactation, elderly, epilepsy or history
haematologic effects, agranulocytosis, aplastic tramadol, phenobarbitone, beta-blockers
of seizure, impaired kidney and liver function,
anaemia, thrombocytopenia, neuroleptic (metoprolol, atenolol, propranolol),
ADULT : Initial dose - 25 mg 3 times daily according to Parkinson's disease, severe hypotension,
malignant syndrome, jaundice, agitation, Hypersensitivity to chlorpromazine products, captopril,norepinephrine, procyclidine, warfarin,
response up to 1 g daily. PAEDIATRIC: Up to 5 years: hypothyroidism, cardiac failure,
insomnia, parkinsonism symptoms, drowsiness, phenothiazines, myelosuppression, coma, epinephrine, cimetidine, ethanol, adrenaline,
Chlorpromazine HCl 100 mg Tablet Largactil Psychosis mania and agitation 0.5 mg/kg body weight every 4 - 6 hours (Maximum 40 phaeochromocytoma, myasthenia gravis & prostate
convulsion and tachycardia, acute dystonia, severe CNS depression, bone marrow antacids, amphetamine, amiodarone,
mg daily). CHILD 6 - 12 years: A third to half adult dose hypertrophy. Avoid in patient hypersensitive to
leukopenia, angioedema, bronchospasm, depression bumetamide, chlorothiazides, clarithromycin,
(Maximum 75 mg daily) phenothiazines, history of narrow-angle glaucoma or
urticaria, hyperprolactinemia, eye, cardiac, skin erythromycin, frusemide, phenytoin,
agranulocytosis. Monitor BP & complete blood count.
& subcutanoues tissue disorders, dry mouth, antiarrhythmics, antidepressants & other
Avoid exposure to sunlight
respiratory depression, neuroleptic malignant antipsychotics, carbamazepine
syndrome. Rarely agranulocytosis, priapism
Postural hypotension, akathisia, tardive
dyskinesia, arrhythmias, constipation, Alcohol, CNS depressant, anticholinergic,
Pregnancy and lactation, elderly, epilepsy or history
haematologic effects, agranulocytosis, aplastic tramadol, phenobarbitone, beta-blockers
of seizure, impaired kidney and liver function,
anaemia, thrombocytopenia, neuroleptic (metoprolol, atenolol, propranolol),
ADULT : Initial dose - 25 mg 3 times daily according to Parkinson's disease, severe hypotension,
malignant syndrome, jaundice, agitation, Hypersensitivity to chlorpromazine products, captopril,norepinephrine, procyclidine, warfarin,
response up to 1 g daily. PAEDIATRIC: Up to 5 years: hypothyroidism, cardiac failure,
insomnia, parkinsonism symptoms, drowsiness, phenothiazines, myelosuppression, coma, epinephrine, cimetidine, ethanol, adrenaline,
Chlorpromazine HCl 25 mg Tablet Largactil Psychosis mania and agitation 0.5 mg/kg body weight every 4 - 6 hours (Maximum 40 phaeochromocytoma, myasthenia gravis & prostate
convulsion and tachycardia, acute dystonia, severe CNS depression, bone marrow antacids, amphetamine, amiodarone,
mg daily). CHILD 6 - 12 years: A third to half adult dose hypertrophy. Avoid in patient hypersensitive to
leukopenia, angioedema, bronchospasm, depression bumetamide, chlorothiazides, clarithromycin,
(Maximum 75 mg daily) phenothiazines, history of narrow-angle glaucoma or
urticaria, hyperprolactinemia, eye, cardiac, skin erythromycin, frusemide, phenytoin,
agranulocytosis. Monitor BP & complete blood count.
& subcutanoues tissue disorders, dry mouth, antiarrhythmics, antidepressants & other
Avoid exposure to sunlight
respiratory depression, neuroleptic malignant antipsychotics, carbamazepine
syndrome. Rarely agranulocytosis, priapism
Hypersensitivity to chlortetracycline or to any
Chlortetracycline 1% Eye Ointment - Eye infections require a broad spectrum antibiotic Instill 1/2 inch 2 - 3 times daily Overgrowth of non-susceptible organisms Allergic reaction (occasional) Ciclosporin
agents in the tetracycline class
Apply directly to affected area twice daily as required Erythema, maculopapular lesions and Hypersensitivity to chlortetracycline or to any
Chlortetracycline 1-3 % Cream - Bacterial skin infections Photosensitivity Not known
for 1 - 2 weeks phototoxicity agents in the tetracycline class
Prophylactic ADULT: First dose of 0.5 ml SC/IM
Tachycardia and hypotension, neurologic
followed after 1 - 4 weeks by a second dose of 1 ml. Infants less than 6 months of age. Revaccination
Avoid administration to immunosuppressed patients, disorders, anaphylaxis and hypersensitivity
Cholera Vaccine - Immunisation of cholera CHILD: 1 - 5 years: 0.1 ml (1st dose), 0.3 ml (2nd is not advisable if serious reaction to the vaccine Yellow fever vaccine
use in pregnant women only when necessary reactions, malaise, low-grade-fever, generalized
dose). CHILD; 5 - 10 years: 0.3 ml (1st dose), 0.5ml has occurred
aches and pains, urticaria
(2nd dose)
Amiodarone, cephalexin, chlorothiazide,
Increased bleeding tendency may develop due to
i) Hypercholesterolemia ii) Pruritus of skin associated diclofenac, digitoxin, digoxin, entacapone,
Hypercholesterolemia: Adjunct: initial, 4 g orally 1-2 hypoprothrombinaemia from vitamin K deficiency, Abdominal discomfort, bleeding tendencies due Complete biliary obstruction, hyperlipidaemia
with partial biliary obstruction iii) Diarrhoea due to bile frusemide, hydrochlorothiazide, leflunomide,
Cholestyramine Resin 4 G Questran light times daily, maintenance, 8 to 16 g in divided doses, may interfere with fat absorption, absorption of fat to hypo- prothrombinaemia, constipation, type III, IV or V. Hypersensitivity to bile-
acid malabsorption iv)Familial hypercholesterolemia - meloxicam, methotrexate, metronidazole,
max 24 g daily CHILD: 50 - 150 mg/ kg 6 - 8 hourly oral soluble vitamins may be decreased and pre-existing flatulence, nausea and vomiting sequestering resins
heterozygous v) Generalized atherosclerosis mycophenolate mofetil, pravastatin, raloxifene,
constipations
valproic acid, warfarin
Infants less than 4 months or in patients with a
Excessive use can lead to salicylate poisoning.
history of salicylate sensitivity. Preparations
Choline Salicylate 8.7%, Cetylkonium For relief of the pain and discomfort in mouth ulcers During therapy, do not give aspirin to children 16
Bonjela Apply to area 4 times daily Not known containing aspirin should not be given to young Not known
Chloride 0.01% Dental Gel and sores, infant teething and denture irritation year. Co-administration with drugs for blood clots
children during treatment to avoid any risk of
and gout. Stomach ulcer. Pregnancy
excessive salicylate levels
When used with gonadotrophins (Follicle
Induction of ovulation: 5000 - 10,000 units one day Thromboembolism, oedema, headache,
Treatment of infertile women to induce ovulation and as Use of human gonadotrophin either to induce Androgen dependent neoplasia prior allergic Stimulating Hormone), ovarian hyperstimulation
Chorionic Gonadotrophin Human following last dose of menotropin. Up to 3 repeat irritability, restlessness, depression and
Pregnyl a luteal support in controlled ovarian hyperstimulation ovulation or as a luteal support, may increase the reaction to chorionic gonadotrophin, active syndrome, enlargement of ovarian cysts or
(HCG) 5000 IU Injection injections of 5000 units each may be given within the tiredness, salt and fluid retention, pain at
cycles risk of ovarian hyperstimulation syndrome (OHSS) thrombophlebitis rupture of ovarian cysts and multiple births may
following 9 days to prevent insufficiency corpus luteum injection site, skin rashes
occur
Thank you my student Syahrir bin Zaini (Pharmacy UIA) for the list. His site can be visited at www.rahsiafarmasi.com To search, press Ctrl-F

Ibrahim Abdullah - http://sir-ib.blogspot.com

Generic Name Trade Name Indications Dosage Form Precautions Adverse Reaction Contraindications Interactions

ADULT and ADOLESCENT above 18 years : 80 - 320 Active or quiescent pulmonary tuberculosis,
Cataracts, corticosteroid withdrawal, cross-
mcg/day administered as 1 or 2 puffs. Recommended Headache, otalgia, epistaxis, nasopharyngitis, fungal, bacterial or viral infections of the
hypersensitivity reactions, history of intraocular
Prophylactic treatment of asthma in adults and starting dose : 80 mcg once daily for patients previously paradoxical bronchospasm, oropharyngeal respiratory system. Not indicated for status Caution when co-administered with potent
Ciclesonide 160mcg Inhalation Alvesco pressure changes, immunosuppressed patients,
adolescents 12 years of age and older maintained on bronchodilators alone. Patient candidiasis, voice hoarseness, bruising, asthmaticus or other acute episodes of asthma. CYP3A4 inhibitors eg ketoconazole, ritonavir
infection, pediatric patients, periods of stress, recent
maintained on another inhaled corticosteroid may cataracts, glaucoma and osteoporosis Not for relief of acute asthma symptoms. Should
nasal surgery, nasal septum ulcers, or nasal trauma
require a higher dose not be stopped abruptly. Pregnancy, lactation
i & ii) Initially 12.5 - 15 mg/kg/day, beginning on the day
before transplant. Maintenance approx 12.5 mg/kg/day
for 3 - 6 months before being tapered off to zero by 1 Etoposide, statins, vaccines,
Only for: i) Patients in whom donor specific Hypersensitivity to ciclosporin or any other
year of transplantation iii) 3 mg/kg/day in 2 divided immunosuppressive drugs except
transplantation cannot be carried out and in young component, rheumatoid arthritis or psoriasis
doses for first 6 weeks. May increased gradually to History of allergic reactions, pregnancy, monitor BP, corticosteroids, live vaccines, nephrotoxic drugs,
children to minimise side-effects of steroids ii) Follow- Nephrotoxicity, hepatotoxicity, gum hyperplasia, patients with abnormal renal function,
maximum 5 mg/kg. Treatment withdrawn if no response serum electrolytes, renal and hepatic function, NSAIDs, hepatic enzyme inducers. Increased
up cases of bone marrow transplant iii) Patients with hypertension, neurotoxicity, convulsions, uncontrolled hypertension, malignancies,
after 3 months iv) ADULT: 5 mg/kg/day in 2 divided hypertension & malignancies. Neoral and ciclosporin level by diltiazem, doxycycline,
severe rheumatoid arthritis not responding to other