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COMMISSION RE: MERYL DOREY AND THE AVN RESPONSE TO HCCC COMPLAINT OF 7 SEPTEMBER 2009 Dear Ms Evans, The following is a critical analysis of ten articles directly referenced by Ms Meryl Dorey in her reply of September 2009 on behalf of herself and her organisation, the AVN, to the complaint submitted by Mr Ken McLeod. All articles mentioned in this document are listed with their PubMed ID (PMID). This will make them easier to find, should any follow up be required. The PMID need only be copied and pasted into the PubMed search box (http://www.ncbi.nlm.nih.gov/pubmed) to bring up the article’s details and often its abstract. Those without a stated PMID are from journals not indexed in the MEDLINE database. Please note that the phrase ‘Wakefield paper’ refers to Dr Andrew Wakefield’s 1998 study – reference . The following material covers information on pages 18-19 of the 27 page version of the reply available at http://avn.org.au/library/images/pdfs/hccc_reply.pdf It should be noted that Ms Dorey’s claim that “Dr Wakefield’s study was only the first of many to indicate a very strong and, in some cases clinically verifiable connection between vaccination and the development of ASDs [autism spectrum disorders]” is incorrect; the Wakefield paper itself does not come to that conclusion. The discussion of the Wakefield paper clearly states “We did not prove an association between measles, mumps, and rubella vaccine and the syndrome described” and suggests further research into such an association. The hype surrounding the MMR vaccine from Wakefield comes from a video released by the Royal Free hospital NHS trust, in which Wakefield asserts no causal link, yet calls for immunisations against measles, mumps and rubella to be separated . It is also worth noting that despite the initial claim being that “Research also suggests that there is a connection between MMR vaccination and the development of autism,.…”, Ms Dorey’s response to Mr McLeod’s criticism of this statement is not to provide any research that suggests a connection between MMR and the development of autism. She instead chooses to list articles which she says hypothesise a vaccine autism link. This kind of ‘side-stepping’ from a dis-proven argument (also known as
including epidemiological studies [9. Some of the ‘truths’ which Medical Veritas aims to expose include a raft of conspiracy theories. indeed. 5.… hypothesising that there could be a connection between vaccination and the development of ASDs” is a collection of ten referenced pieces. (d) make the bad seem good. For Ms Dorey to make such a grand statement without any justification is completely dishonest and dangerous. . shaken baby syndrome [15 and 17] and HIV .“newspeak. 7 and 8]. The entire article attempts to convince the reader of this disproved hypothesis.’s positions using all the tools of doublespeak or.‘moving the goalposts’ – or even widening in this case) is dishonest. a weak attempt to rationalize the healthcare establishment. in some cases clinically verifiable connection between vaccination and the development of ASDs” she provides no evidence for her statement of a clinically verifiable connection between vaccination and the development of ASDs. autism . Her selection of “articles published in peer-reviewed journals. It should be noted that hypothesising a connection does not constitute proof. since Wakefield’s initial untruthful and discredited comments regarding the MMR vaccine much disconfirming evidence has emerged [3. and (h) create dissonance between reality and what their narrative said or did not say”. Despite Ms Dorey’s claim that “Dr Wakefield’s study was only the first of many to indicate a very strong and. and the scare tactics used by the anti-vaccination movement. is not a reliable source of unbiased. the peer review process in mainstream journals is used to quash information which could hurt the Journals’ owners and/or advertisers. vaccine-injury compensation Thimerosal. 11 and 12]. ‘Key realities about autism. regarding vaccines . at best. and reflects negatively on the credibility of both Ms Dorey and the AVN. as George Orwell. The lack of evidence for the hypothesis suits the ‘journal’ it is in: ‘Medical Veritas’. (f) make the negative appear positive. and autism-related research’ (no PMID) is partially an attempt to rebut an earlier article  that appeared in Skeptical Inquirer magazine. • The first referenced paper in Ms Dorey’s reply. vaccines. but rather a haven for conspiracy theories that do not pass the peer-review process. This journal. (b) distort reality. (e) avoid and/or shift responsibility. The first paragraph of the abstract of this article sets the tone perfectly: “The propaganda dispensed by Public health care and vaccine apologists is. (g) create a false verbal map of the world. scientifically accurate information. 4. .”. 10. According to a message  from the “Editor-in-Chief and President/Founder Medical Veritas International Inc”.’s called it in his book 1984. 6. (c) pretend to communicate. This is most likely why Ms Dorey had merely hypothesising a link as her criteria for inclusion in the list – there is no evidence for such a connection. explaining the lack of evidence for assuming the vaccine ingredient thimerosal causes autism. to: (a) mislead. There has not been a single clinically verified case of a vaccine (or vaccines) being the cause of autism. and indeed the paper.
or JPANDS. the paper reports a high correlation between ASD and chronic inflammation in the gut. The third paper. The paper does not mention ASDs. ‘Gastrointestinal abnormalities in children with autistic disorder’ (PMID: 10547242) observes “The upper gastrointestinal evaluations of children with autistic disorder support the presence of a chronic inflammatory process in the gut. which curiously do not include ASDs. ‘Measles Vaccination and Inflammatory Bowel Disease: A National British Cohort Study’ (PMID: 11151885) found no association between the monovalent measles vaccine and all three of the conditions observed. with no reference to vaccines at all. These include (in JPANDS) HIV denial . The sixth paper. the belief that the “gay male lifestyle” leads to a life expectancy shortened by 20 years  and casting doubt on the concept of shaken baby syndrome . ‘Constipation With Acquired Megarectum in Children With Autism’ (PMID: 14523189) describes a correlation between children with ASDs and constipation with acquired megarectum. replying to criticisms of the research methodologies used in two of their previous studies. peer-reviewed journal to hypothesise a vaccine-autism link – and it is done so by Dr Andrew Wakefield. far right-wing ideals. ‘Autism. sent in by Wakefield and colleagues. This non-peer-reviewed journal is not an accurate source of unbiased information. The paper at no point makes any reference to any connection between vaccines and autism. This defence of their previous studies is just that. Interestingly. and does not mention any hypothesis linking vaccines to autism. The seventh paper. • • • • • .”. Of the ten articles Ms Dorey references. who has been shown to have had significant conflicts of interest. this is the only one from a mainstream. including: a patent on a monovalent alternative to the MMR vaccine  and being paid to find a link between MMR and autism by a lawyer representing parents making a court case blaming their children’s autism on the vaccine . but suggests that “MMR vaccination is a candidate worthy of investigation” regarding the cause of autism.• The second paper. as did the Wakefield paper. The fifth paper referenced. That is. ‘Measles virus and autism’ (PMID: 11085720) is a letter published in the Lancet. ‘An Investigation of the Association Between MMR Vaccination and Autism in Denmark’ (no PMID) was published in the ‘Journal of American Physicians and Surgeons’. AAPS is a far right-wing organisation which fills its publications with papers that mirror the organisation’s fringe. as reported by Wakefield et al. in contrast to Ms Dorey’s statement preceding the references. The fourth paper. the journal of the Association of American Physicians and Surgeons (AAPS). and at no point hypothesises a vaccine-autism link. abortion causing premature birth and birth defects in the mother’s future pregnancies . those conflicts of interest are undisclosed in this article. viral infection and measles mumps rubella vaccination’ (PMID: 10731332) is a review. headed by Andrew Wakefield (of the Wakefield paper) in which he puts forward no new evidence. This paper does not address vaccines or the cause of ASDs.
suggest a connection between the MMR vaccine and ASDs: “In section 7. Despite being described by Ms Dorey in the preceding explanation as a study hypothesising a connection between vaccines and autism. They found an increase in antibodies against myelin basic protein (MBP) in autistic children that had the MMR vaccine.”” . Mr McLeod cites the AVN. who has well-documented conflicts of interest.2. a later study  found no such correlation in autistic children. and are known for publishing absurd.…” He then goes on to say that.1.3. with Wakefield as one of the authors. It is a paper that presents evidence of a link between the measles virus and the gut problems suffered by a large proportion of autistic children. It is telling that of the ten articles Ms Dorey selected. as without doing so the previous paper and accompanying explanation are likely to be misconstrued by those who initially misconstrued the paper. this article does not mention any form of vaccination. yet a causal relationship was not hypothesised. enterocolitis and developmental disorder’ (PMID: 12142949) is a proceedings paper from the conference ‘Meeting on Microbiology.. and the other is written by Dr A. “the AVN is referring to the Wakefield study published in the Lancet.s statement that. ‘Potential viral pathogenic mechanism for new variant inflammatory bowel disease’ (PMID: 11950955) examined an association between infection with the measles virus and the pathology of inflammatory bowel disease in autistic children. The ninth paper. fringe conspiracy theories. ‘Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism’ (PMID: 12145534) suggests that the immune response of autistic people to the MMR vaccine is different to that of non-autistic people. and does not hypothesise a vaccine-autism link. nor peer-reviewed. The third was a review article.• The eighth paper. Two of them are in journals which are not mainstream. the only three that support her assertion are either published in fringe conspiracy journals. only three hypothesise this. Of the ten papers cited.… hypothesising that there could be a connection between vaccination and the development of ASDs”. “Research also suggests that there is a connection between MMR vaccination and the development of autism. ‘Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia. The ten articles were referenced by Ms Dorey in an attempt to prove that more research. • • To follow up. The tenth paper. As MBP is found in myelin (part of neurons) it was hypothesised that the production of these antibodies may contribute to the symptoms of autism. Despite being put under the subheading ‘vaccines and autism’ in the journal. It should be noted that the AVN’s reply stated these papers were “a selection of the many articles published in peer-reviewed journals. Immunology and Toxicology of autism and other developmental disorders’. Wakefield. the paper makes no mention of any vaccine. other than the Wakefield paper.
10. by instead listing articles which she stated were published in peer reviewed journals and hypothesise “a connection between vaccination and the development of ASDs” simply drew attention to her own lack of evidence for this claim. with research suggesting a lack of association [4. The selection of articles Ms Dorey included suggests she is at best ignorant of the lack of evidence for her claims and those of her organisation. Ms Dorey’s apparent attempt to distract from this. 6. 5. or at worst intentionally deceptive. Signed.As has been shown in this analysis. 11 and 12]. 8.…” remains demonstrably untrue. 9. the AVN’s initial statement “Research also suggests that there is a connection between MMR vaccination and the development of autism. 7. Tom Sidwell ..
Risi S. Rogers S. Linnell J. Richler J. Taylor B. Lord C. Goldberg WA. Hyman SL.285(9):1183-5.References: : Ileal-lymphoid-nodular hyperplasia. Baird G. Fombonne E. Minshew N. and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis.htm Transcript of the video released by the Royal Free Hospital NHS trust. 2002 Feb 16. Valentine A.36(3):299-316.118(1):e139-50. 1998 Feb 28. Petropoulos MC. 2008 Oct. Charman T. Simmons A. measles. 2001 Feb 24. Brown D.34(3):543-53. Malik M. Hepburn S. Pediatrics. Volkmar FR. Dales L. Walker-Smith JA. PMID: 11231748 : Mumps. Sullivan P. Pediatrics.322(7284):460-3.353(9169):2026-9. Thomas B. and pervasive developmental disorder in children. 2001 Oct. FavotMayaud I. Li J. Dunn M. Jin L. Bernier R. TagerFlusberg H. Miller E. Spence MA. PMID: 10376617 : Time trends in autism and in MMR immunization coverage in California. MMR and measles virus. Taylor B. Smith NJ. : Autism and measles. Davies SE. Landau S. PMID: 16818529 : Measles vaccination and antibody response in autism spectrum disorders. J Autism Dev Disord. mumps. Dhillon AP. non-specific colitis. BMJ. 2001 Mar 7. Arch Dis Child. Stowe J. Dawson G. Fombonne E. 1999 Jun 12. Casson DM. mumps. Berelowitz M. Luyster R. PMID: 9500320 (Now retracted) : http://briandeer. PMID: 11222420 : Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study. Thomson MA. Hammer SJ. Chakrabarti S.93(10):832-7. Afzal M. Wakefield AJ.324(7334):393-6.108(4):E58. Farrington CP. Zakarian R. Andrews N. Lingam R. del Mar Melero-Montes M. and rubella vaccination and bowel problems or developmental regression in children with autism: population study. McLeanHeywood D. PMID: 18252754 : Measles. 2006 Jul. 2004 Apr. Lancet. Simonoff E. and rubella vaccine: no epidemiological evidence for a causal association. Lancet. Murch SH. Meng L. Bennett A. Quebec. Kaye JA. Sham P. PMID: 16729252 : Pervasive developmental disorders in Montreal. Chen W. McMahon WM. Pickles A. PMID: 11581466 . Canada: prevalence and links with immunizations. Jick H.351(9103):637-41. Goudie-Nice J. Hsu WL. Chandler S. Miller E. Harvey P. Loucas T. JAMA. Sigman M. Fombonne E.com/wakefield/royal-video. Meldrum D. Waight PA. 2006 Apr. PMID: 11850369 : No evidence for links between autism. Psychol Med. PMID: 15259839 : No evidence for a new variant of measles-mumps-rubella-induced autism. Anthony A. BMJ.
R. 1(1):117-29 : Digestion-gut-autism connection: the Specific Carbohydrate Diet.38(2):324-32. NS. Elaine.M. Bauer. Nov/Dec 2007 – mentioned on the front cover as ‘Vaccines and Autism: Myths and Misconceptions’ : http://www.6.co. PMID: 17588145 .medicalveritas. 2007: 12 (4): 116. G. Lainhart JE. A. Kirkman NJ. 3(2):1019-40 : Hypothesis--Examining the causes of AIDS. Libbey JE.M. 2004 Nov.htm The patent Andrew Wakefield had on an alternative monovalent vaccine. J Autism Dev Disord. Stevenson EK.pdf “Message from the Editor-in-Chief concerning Medical Veritas®: The Journal of Medical Truth”. The news article in the Sunday Times where the payments to Wakefield. Sweeten TL. 2004 Apr. Uchiyama T. : Shaken baby syndrome or medical malpractice?.910 expenses” were first exposed. 2008 Feb.37(2):210-7. Gary S. A. Ali.com/wakefield/vaccine-patent. 2006 Apr. Medical Veritas.uk/tol/news/uk/article1265373. Coon HH. totalling “£435. J. Medical Veritas. Fujinami RS. Ali. 2007 Feb. Leestma. Brent. McMahon WM. Miller JN. Goldman PhD. 1(2):261-71 : Analysis of causes that led to subdural bleeding and rib fractures in the case of Baby Patrick Gorman. Lehrman. Inaba Y. which represents a substantial conflict of interest. Ali. Medical Veritas. : Induced Abortion and Risk of Later Premature Births. JPANDS 2003: 8 (2): 46–9 : Homosexuality: Some Neglected Considerations. 3(1):901-13 : Questioning HIV/AIDS: Morally Reprehensible or Scientifically Warranted?. 2006 Nov.timesonline.M. Medical Veritas. : Are there enhanced MBP autoantibodies in autism?. Kurosawa M. The Anti-Vaccination Movement Skeptical Inquirer 31. JPANDS 11(1): 14-6 : http://briandeer. A. JPANDS. plus £3. BC.com/images/MessageSenEd. : http://www. H. J Autism Dev Disord.: MMR-vaccine and regression in autism spectrum disorders: negative results presented from Japan. S.643 in fees. PMID: 16865547 : Novella. JPANDS 10 (3): 80-2 : "Shaken Baby Syndrome": Do Confessions by Alleged Perpetrators Validate the Concept?.ece MMR doctor given legal aid thousands. Calhoun.