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GENERIC NAME: cephalexin TRADE NAME(S): Keflex, Apo-Cephalex, Novo-Lexin, NuCephalex CLASSIFICATION: THERAPEUTIC: anti-infective PHARMACOLOGIC :1ST Generation cephalosporins THERAPEUTIC ACTION(S)/EFFECT(S): Bactericidal action against susceptible bacteria. Bind to bacterial cell wall membrane, causing cell death. USES/INDICATIONS: Treatment of: Skin infectionsPneumonia-Ottis media-Urinary tract infections-Bone and Joint infections-Septicemia. Not suitalble for the treatment of meningitis. CONTRAINDICATIONS/CAUTIONS: Contraindicated in: Hypersensitivity to cephalosporins. serious hypersensitivity to penicillins. Use Cautiously In: Renal impairment- History of G.I. disease- Geriatric patients (consider age, wt., body mass, current medications, and chronic disease states) OBPregnancy or lactation (half-life is shorter and blood levels lower). NORMAL DOSAGE AND ROUTE(S): PO (ADULTS): Most infections - 250-500 mg q 6 hr. Uncomplaicated cystitis, skin and soft tissue infections, streplococcal pharyngitis -500 mg q 12 hr. PO (CHILDREN): Most infections- 25-50 mg kg/day divided q 6-8 hr.

wheezing) Discontinue drug and notify physician . cramps. •before initiating therapy obtain hx of cephalosporin/penicillin hypersensitivity. Concurrent use of loop diuretics or aminoglycosides may increase risk of renal toxicity. decreased dosage if impaired •observe patient for signs and symptoms of anaphylaxis (rash. May be given of full or . •obtain C&S before therapy. across placenta and enters breast milk in low concentrations. headache GI: diarrhea. NURSING IMPLICATIONS OF ADMINISTRATION: Assessment •Assess for infection (vital signs. sputum. urine and stool. Implementation •PO: Administer around the clock.appearance of wound. fatigue. DistributionWidely.(increased in renal impairment) ADVERSE EFFECTS/COMMON SIDE EFFECTS: CNS: SEIZURES (HIGH DOSES) dizziness. vaginal discharge. anemaia.pruritus.PHARMACOKINETICS: Absorption-Rapid. pruritis. GU: vaginitis. INTERACTIONS: DRUG-DRUG : Probenecid. Allergic reactions: anaphylaxis and serum sickness. nausea. urticaria.decrease excretion and increased blood levels of really excreted cephalosporins. Half-life-50-80 mins.laryngeal edema. DERMA: rashes. vomiting. •assess renal function. HEMAT: blood dyscrasias.WBC) at the beginning and during therapy.

do not double dose. TEACHING POINTS: •Instruct Patient to complete full course of therapy even if symtoms subside. Shake oral suspension well before giving and refrigerate . (fever. •Can be taken with meals. Missed dose should be taken as soon as possible unless almost time for next dose. •Advise patient to report any sign of superinfection (furry overgrowth on tongue. difficulty breathing. best on empty stomach •Take at equal intervals around clock to maintain blood levels. rash) •Caution patient that alcohol should be avoided during and for several day after theraphy. •Carry identification (medical-alert) if cephalosporin allergic. vaginal discharge or itching. Advise patient not to treat diarrhea. •Notify physician of symptoms of allergic reaction. loose foul smelling stools) •Instruct patient to notify Heath Care Professionals to report if fever and diarrehea develop. •Increse fluid intake. .empty stomach. Given with food may minimize GI irritation.