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DRUG CLASSIFICATI ON Pharmacologi c class: Lowmolecularweight heparin Therapeutic class: Anticoagulan t





Enoxapari ne Sodium (Clexane)

1 mg/kg subcutaneo usly q 12 hours, given with aspirin 100 to 325 mg P.O. once daily until patient is clinically stable

Inhibits thrombus and clot formation by blocking factor Xa and factor IIa. This inhibition accelerates formation of antithrombin III-thrombin complex (a coagulation inhibitor), thereby deactivating thrombin and preventing conversion of fibrinogen to fibrin.

Indication: Prevention of ischemic complications of unstable angina or non-Q-wave myocardial infarction Contraindicatio n: • Hypersensitivity to drug, heparin, sulfites, benzyl alcohol, or pork products • Thrombocytopeni a • Active major bleeding

CNS: dizziness, headache, insomnia, confusion, cerebrovascular accident CV: edema, chest pain, atrial fibrillation, heart failure GI: nausea, vomiting, constipation GU: urinary retention Hematologic: anemia, bleeding tendency, thrombocytopeni a, hemorrhage Metabolic: hyperkalemia Skin: bruising, pruritus, rash, urticaria Other: fever; pain, irritation, or

✔ Monitor CBC and platelet counts. Watch for signs and symptoms of bleeding or bruising. ✔ Monitor fluid intake and output. Watch for fluid retention and edema. ✔ If patient will selfadminister drug, teach proper injection technique. ✔ Instruct patient to promptly report irregular

✔ Monitor for sudden blood pressure drop within . or hives. ✔ Advise patient to weigh himself regularly and to report gains. rash. weakness. unusual bleeding or bruising. ✔ Teach patient safety measures to avoid bruising or bleeding. drowsiness.erythema at injection site heart beat. fatigue. dizziness. NURSING RESPONSIBILITIES DRUG DOSAGE DRUG CLASSIFICATI ON Pharmacologi c class: Angiotensinconverting enzyme ACTION INDICATION/ CONTRAINDICATI ON SIDE EFFECTS Captopril (Capoten) Prevents conversion of angiotensin I to Indication: Hypertension Contraindicatio CNS: headache.

and liver function test results. Monitor hematologic . dyspnea. asthma. Tell patient his ability to taste may . angioedema ✔ ✔ ✔ ✔ 3 hours of initial dose if patient is receiving concurrent diuretics and on a low-sodium diet. to lower blood pressure.(ACE) inhibitor Therapeutic class: Antihyperten sive angiotensin II. kidney. anorexia GU: proteinuria. eosinophilic pneumonitis Skin: rash. Decreased aldosterone secretion prevents sodium and water retention. agranulocytosis. diarrhea. which leads to decreased vasoconstric tion and. bronchitis. leukopenia. pancytopenia. hypotension EENT: sinusitis GI: nausea. Tell patient to take drug 1 hour before meals on empty stomach. gynecomastia. renal failure Hematologic: anemia. tachycardia. ultimately. erectile dysfunction. decreased libido. thrombocytopeni a Metabolic: hyperkalemia Respiratory: cough. Check for proteinuria monthly and after first 9 months of therapy. Also decreases blood pressure by increasing plasma renin secretion from kidney and reducing aldosterone secretion from adrenal cortex. n: Hypersensitivity to drug or other ACE inhibitors Angioedema (hereditary or idiopathic) insomnia CV: angina pectoris.

pruritus Other: ✔ • Assess for symptomati c improvemen t. creating protective coating on Indication: Pathologic hypersecretory conditions Contraindicatio n: Hypersensitivity to drug CNS: dizziness. ✔ Monitor blood glucose level in diabetic patient. DRUG DOSAGE DRUG CLASSIFICATI ON Pharmacologi c class: Proton pump inhibitor Therapeutic class: GI agent ACTION INDICATION/ CONTRAINDICATI ON SIDE EFFECTS NURSING RESPONSIBILITIES Pantopraz ole Sodium (Pantoloc) 40mg TIV OD Reduces gastric acid secretion and increases gastric mucus and bicarbonate production. abdominal pain. ✔ Caution patient to avoid overthe-counter medications unless approved by prescriber. fever decrease during first 2 to 3 months of therapy. headache CV: chest pain EENT: rhinitis GI: vomiting. dyspepsia Metabolic: hyperglycemia Skin: rash.Other: altered taste. ✔ Tell patient . diarrhea.

✔ Instruct diabetic patients to monitor blood glucose level carefully and stay alert for signs and symptoms . or splitting. ✔ Tell patient he may take tablets with or without food.gastric mucosa injection site reaction to swallow delayedrelease tablets whole without crushing. ✔ Explain that antacids don't affect drug absorption. chewing.

dystonia. ✔ Supervise ambulation. ✔ Monitor CBC and kidney and liver function test results. lightheadedness. especially in elderly patients. drowsiness. depression. tremor. or tartrazine • Coma or CNS depression • Narrow-angle glaucoma CNS: dizziness.of hyperglyce mia. . stupor. dysarthria. manic or hypomanic episodes. anticonvulsa nt. sedativehypnotic. DRUG DOSAGE DRUG CLASSIFICATI ON Pharmacologi c class: Benzodiazepi ne Therapeutic class: Anxiolytic. paresthesia. Relaxes skeletal muscles of spine by inhibiting polysynaptic afferent Indication: Before endoscopy Contraindicatio n: • Hypersensitivity to drug. lethargy. headache. alcohol. skeletal muscle relaxant (centrally acting) ACTION INDICATION/ CONTRAINDICATI ON SIDE EFFECTS NURSING RESPONSIBILITIES Diazepam (Valium) 5mg/tab 1 tab OD Produces anxiolytic effect and CNS depression by stimulating gammaaminobutyric acid receptors. other benzodiazepines. vivid dreams. anger. restlessness. disorientation. slurred speech. extrapyramidal ✔ • Monitor vital signs and respiratory and neurologic status.

libido changes Hematologic: ✔ Instruct patient to move slowly when sitting up or standing. gynecomastia. difficulty swallowing. hypertension. cardiovascular collapse EENT: blurred vision. diarrhea. increased salivation GU: urinary retention or incontinence. nystagmus. reactions. constipation.pathways. Advise him to dangle legs briefly before getting out of bed. menstrual irregularities. Controls seizures by enhancing presynaptic inhibition. palpitations. hypotension. nasal congestion GI: nausea. mild paradoxical excitation CV: bradycardia. diplopia. to avoid dizziness from blood pressure decrease. gastric disorders. vomiting. tachycardia. .

pruritus. muscular disturbances Respiratory: respiratory depression Skin: dermatitis. decreased appetite. rash. edema. fever. urticaria. leukopenia. physical or psychological drug dependence or tolerance . hiccups. diaphoresis Other: weight gain or loss. agranulocytosis.blood dyscrasias including eosinophilia. and thrombocytopeni a Hepatic: hepatic dysfunction Musculoskeletal: muscle rigidity.