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Glycoscia® (Salacia - Salvia - Resveratrol Complex)

60 Veggiecaps per bottle.

Suggested retail price: 24.95
Glycoscia is formulated from three well- 2, particularly with regard to postprandial hyperglycemia.
researched botanicals from the traditional They may be used as monotherapy in conjunction with an
texts of China, India, and Japan and the appropriate diabetic diet and exercise, or they may be used
flavonoids quercetin and resveratrol. in conjunction with other anti-diabetic drugs. Inhibition
Glycoscia supports the body’s natural ability of these enzyme systems reduces the rate of digestion of
to maintain healthy blood sugar levels. It complex carbohydrates. Less glucose is absorbed because the
also may have anti-glycation end product carbohydrates are not broken down into glucose molecules.
effects as well. In diabetic patients, the short-term effect of these drugs
therapies is to decrease current blood glucose levels: the long
Product History term effect is a small reduction in hemoglobin A1c level.
Glycoscia was originally developed in 2007 for use in the • The petroleum ether extract of the root bark of S. oblonga
D’Adamo Clinic. Wall. (Celastraceae) (SOB) was studied in streptozotocin
(STZ) diabetic rats and anti-lipid peroxidative activity of
Description/Background the same was studied in the cardiac tissue. SOB prevented
Resveratrol significantly the streptozotocin-induced hyperglycaemia and
• Found primarily in red wine and red grape skins. hypoinsulinaemia (3)
• In a now-famous recent Harvard study, mice fed resveratrol • In a study conducted by Kowsalya et at., it was determined
were reported over time to be thinner and healthier with that 2.5 to 5.0 grams of Salacia Oblonga daily is effective in
increased life-spans. Each capsule of Glycoscia supplies a lowering the blood glucose, serum cholesterol, triglycerides
full 50 mg of Resveratrol, providing 50% trans-resveratrol and increasing the HDL cholesterol levels of non-insulin
compounds. dependent diabetes patients.
• This polyphenolic coumpound that exists in nature as cis- • The presence of Salacia oblonga extract tended to lower
and trans- stereoisomers is primarily found in red wine, red postprandial glycemia and significantly reduced the
grape skins, purple grape juice, and mulberries. A number postprandial insulin response. The increase in breath hydrogen
of beneficial health effects, such as anti-cancer, anti-viral, excretion suggests a mechanism similar to prescription alpha-
neuroprotective, anti-aging, anti-inflammatory and life- glucosidase inhibitors. (1)
prolonging effects have been reported. It is also used for • Salacia oblonga extract functions as a PPAR-alpha activator,
atherosclerosis, lowering cholesterol levels, and increasing providing a potential mechanism for improvement of
HDL cholesterol levels postprandial hyperlipidemia and hepatic steatosis in diabetes
and obesity. (4)
Salacia oblonga Root
• The herb Salacia oblogna root has been used for thousands Quercetin
of years in Ayurvedic medicine. Salacia plays an important • This is the most abundant of the flavanoid molecules that
role in supporting natural carbohydrate metabolism and naturally can be found in apples, onion, tea, berries, brassica
in maintaining the homeostasis of lipid metabolism. The vegetables, seeds, nuts, flowers, barks and leaves. It promotes
inhibition of these substances is thought to help the body insulin secretion, increases vitamin C levels, protects blood
maintain healthy blood glucose levels. vessels, prevents easy bruising and supports the immune
• This herb is a native of India and Sri Lanka and has been used system. It is also an aldose reductase inhibitor. Aldose
in traditional Indian medicine and Ayurveda successfully for reductase has been linked to chronic complications associated
years. The active constituents, salacinol and kotalanol, inhibit with diabetes such as peripheral neuropathy, retinopathy, and
alpha-glucosidase and aldose reductase. The inhibition of cataracts, thus quercetin protects against the complications
these substances decreases the breakdown of carbohydrates often associated with diabetes.
into absorbable monosaccharides and therefore decreases • Quercetin is also a sirtuin-like deacetylase inhibitor.
postprandial blood glucose levels. (2) • Red Sage Root (Salvia miltiorrhiza)
• Alpha-glucosidase inhibitors are used to establish greater • Antioxidant support for circulatory health.
glycemic control over hyperglycemia in diabetes mellitus type
• Used traditionally in Chinese medicine, recent research the rate of free radical production to 50-times the rate of free-
in the West confirms Salvia’s importance for supporting radical production by unglycated proteins. AGEs attached to LDL-
cardiovascular health and liver function. cholesterol accelerates oxidation and subsequent atherosclerosis.
• Sage root is used for the treatment of agina and chronic The irreversible cross-linked proteins of AGEs in vessel collagen
glomerulonephritis. It is useful in reducing all uremic indices also contributes to atherosclerosis, as well as to kidney failure --
when used in the early stages of kidney failure. conditions worsened in diabetes. (9) Cataracts are composed of
urea-insoluble proteins in the lens of the eye. AGEs aggravate
• Salvia has been used in treatment of chronic renal protein cross-linking in the plaques & tangles of Alzheimer’s
insufficiency in China for at least thirty years. In 1989, disease, thereby accelerating neuron death. (10)
Japanese researchers reported on isolation of a constituent of
salvia responsible for promoting renal function, which was The higher glycation rate in diabetics is undoubtedly related to the
identified as lithospermate B which enhances plasma blood fact that diabetes greatly resembles accelerated aging. Hemoglobin
flow and reduces glomerular filtration rate in the kidneys of glycation is often used as a time-integrated (as opposed to
laboratory animals suffering renal failure. In 1993, Chinese instantaneous) measure of blood glucose levels in diabetics. AGEs
researchers in Hangzhou reported on the effect of salvia are universal symptoms of aging -- adversely affecting skin, lungs,
injection in patients undergoing peritoneal dialysis for renal muscles, blood vessels and organ-function in general. Increased
failure, claiming it could markedly increase the clearance rate insulin resistance and other symptoms of diabetes are commonly
and ultrafiltration rate of creatinine, urea nitrogen, and uric seen features of aging. Diabetes-like atherosclerosis and the
acid (6). A study in Japan published in 2000 further noted that resultant generalized reduction in blood flow has an adverse effect
salvia inhibited nitrogen oxide (NO) production which was on most organ systems.
thought to be a contributor to both acute and chronic renal It appears that fructose and galactose have approximately ten times
failure , while a study in Korea published in 2004 suggested the glycation activity of glucose, the primary body fuel. Glycation
that scavenging of free radicals in the kidneys was part of is the first step in the evolution of these molecules through a
the mechanism of action for both salvia and its component complex series of very slow reactions in the body known as
lithospermate B (8) Amadori reactions, Schiff base reactions, and Maillard reactions;
all lead to advanced glycation endproducts (AGEs). Some AGEs
Maitake Mushroom
are benign, but others are more reactive than the sugars they are
• Research suggests that Maitake improves the lipid profile and derived from, and are implicated in many age-related chronic
appears to have blood sugar modulating effects. A 2002 study diseases such as: type II diabetes mellitus (beta cell damage),
concluded that Maitake favorably influences glucose/insulin cardiovascular diseases (the endothelium, fibrinogen and collagen
metabolism in insulin-resistant mice. Research suggests that are damaged), Alzheimer’s disease (amyloid proteins are side
maitake mushroom is immunostimulatory, can lower blood products of the reactions progressing to AGEs), cancer (acrylamide
pressure, improve the lipid profile and appears to have some and other side products are released), peripheral neuropathy (the
hypoglycemic effects. A study conducted in 2002 concluded myelin is attacked), and other sensory losses such as deafness (due
that maitake mushroom, favourably influences glucose/ to demyelination) and blindness (mostly due to microvascular
insulin metabolism in insulin-resistant mice. The lowering of damage in the retina). This range of diseases is the result of the
both circulating glucose and insulin concentrations suggests very basic level at which glycations interfere with molecular and
that maitake mushroom works primarily by enhancing cellular functioning throughout the body and the release of highly-
peripheral insulin sensitivity. oxidizing side products such as hydrogen peroxide. (11)
Actions and Indications Glycated substances are eliminated from the body slowly, since
GlycosciaTM is used to treat diabetes mellitus and insulin the renal clearance factor is only about 30%. This implies that the
resistance. The blend of ingredients have the following list of half-life of a glycation within the body is about double the average
actions: cell life. Red blood cells are the shortest-lived cells in the body
(120 days), so, the half life is about 240 days. This fact is used
• Anti-inflammatory in monitoring blood sugar control in diabetes by monitoring the
• Hypoglycemic glycated hemoglobin level. As a consequence, long-lived cells
• Enhances peripheral insulin sensitivity (such as nerves, brain cells) and long-lasting proteins (such as DNA,
eye crystalline, and collagen) may accumulate substantial damage
• Antioxidant over time. Metabolically-active cells such as the glomeruli in the
• Enhances glomerular filtration kidneys, retina cells in the eyes, and beta cells (insulin-producing)
• Alpha-glucosidase inhibitor in the pancreas are also at high risk of damage. The epithelial cells
of the blood vessels are damaged directly by glycations, which
• Aldose reductase inhibitor are implicated in atherosclerosis, for example. Atherosclerotic
• Decreases serum cholesterol and triglycerides; increases plaque tends to accumulate at areas of high blood flow (such as the
HDL levels entrance to the coronary arteries) due to the increased presentation
of sugar molecules, glycations and glycation end-products at these
The glycation theory of aging and tissue damage points. Damage by glycation stiffens the collagen in the blood
Glycation (also called the Maillard reaction, or non-enzymatic vessel walls which can lead to high blood pressure. Glycations
glycosylation) is a reaction by which reducing sugars become also cause weakening of the collagen in the blood vessel walls,
attached to proteins without the assistance of an enzyme. which may lead to micro- or macro-aneurisms; this may cause
Advanced Gylcation Endproducts (AGEs) in tissues increase strokes if in the brain.
Synergistic Products
• Histona Ulterior (metabolic support)
• Connectivar (connective tissue support)
• Scienca (epigenetic enhancement)
One (1) capsule twice daily or as directed by a health care professional.

See Also
• Carnosine
• Cell Adhesion Molecules (CAMs)
• Endothelial dysfunction
• Flavonoid glycosides
• Galectin 3, hGal-3
• Glucose-6-phosphate dehydrogenase deficiency
• Glycation
• Glycosylation
• Longevity
• Oxidative stress
• Polyamines
• Rhesus (Rh) Blood Group

1. J Am Diet Assoc. 2005 Jan;105(1):65-71.
2. Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1339-40
3. Indian J Physiol Pharmacol. 1999 Oct;43(4):510-4
4. Toxicol Appl Pharmacol. 2006 Feb 1;210(3):225-35. Epub 2005 Jun 21
5. North American Pharmacal , Inc Technical Reference. 89-90
7. Am J Chin Med. 2005;33(3):491-500.
8. Life Sci. 2004 Aug 27;75(15):1801-16
9. DiabetesS 46(Suppl 2):S19-S25 (1997)
10. Brain Research Review 23:134-143 (1997).

Model: NP056
* Manufactured by: Genoma Nutritionals

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