PERSONALIZED REGENERATIVE MEDICINE David A. Steenblock, B.S., M.S., D.O.

Stem Cells & Amyotrophic Lateral Sclerosis (ALS)
ALS – The Devil’s Spawn If the devil himself were challenged to come up with a supremely insidious way to torment people he would be hard-pressed to come up with anything as devastatingly horrific as ALS (Amyotrophic lateral sclerosis). This neurodegenerative disease (also referred to as "Lou Gehrig's disease") is characterized by the degeneration of motor neurons. The end result is a gradual loss of various or virtually all motor abilities such as the ability to move about, swallow and even breathe. Some sufferers develop frontotemporal dementia http://en.wikipedia.org/wiki/Frontotemporal_dementia. The appearance of symptoms and rate of progression varies somewhat from person-to-person and appears linked to genetic influences.

There is no cure for ALS. Researchers and doctors have found that certain drugs and natural compounds appear to slow progression in some sufferers. Stems Cells & ALS – Scientific Support What, if anything, can adult (nonembryonic) stem cells do for ALS? Quite a lot according to various published animal and human studies. For instance, in 2009 researchers at the University of Bristol in England showed that bone marrow derived mesenchymal stem cells secrete brain-derived neurotrophic factor (BDNF) which was shown to keep cortical neurons (from rats) that were manipulated so as to encourage die-off didn’t. http://www.ncbi.nlm.nih.gov/pubmed/19411199 And in a human study conducted in Turkey, thirteen sporadic (non-hereditary) ALS patients with severe loss of ability to move had bone marrow (BM)-derived hematopoietic progenitor stem cells injected into their anterior spinal cords. Bottom line: Nine of these showed clinical improvements compared to their pre-treatment status, while one showed no improvements but didn’t decline either. Three passed away. http://www.ncbi.nlm.nih.gov/pubmed/19012065 Here in the US a number of human studies involving the use of bone marrow derived stem cells for ALS are underway. One is going on at Emory University. Page 1 of 3

Of course, there is no way ALS sufferers here in the US can get treated with pure autologous (= from self) bone marrow derived stem cells outside of FDA approved clinical trials. However, there is no law or regulation that bars doctors here from harvesting an ALS patient’s own stem cell rich bone marrow and giving it back to him or her via IV or lumbar puncture or such. Case-in-point: Dr. David Steenblock has been doing whole bone marrow treatments for more than five years now (More than 1,000 to-date.) This body of pioneering clinical work includes more than a few ALS patients. Stem Cells & ALS – Clinical Use in People The use of stem cells from a person’s own body that undergo “significant manipulation,” say, are cultured and encouraged to multiply or reproduce, requires FDA approval in the US. However, it is perfectly legal for a doctor to take stem cell-rich bone marrow or fat tissue and give it back to a patient with “minimum manipulation.” With this in mind, Dr. David Steenblock began doing whole bone marrow transplants starting around 2006. Since then he has successfully done over 1,000 of them. This body of clinical work includes having treated ALS patients with their own bone marrow, typically in conjunction with other therapies and treatments (such as this diet http://stemcell.md/diets/als_diet.pdf) that address the various known players and contributors to the genesis and progression of this insidious disease. So what kind of results has these whole bone marrow treatments produced in ALS sufferers? Well, if you have about 4 minutes to spare, you can meet one of them (Geno) and learn what he has experienced on the heels of not one – but 5 such whole bone marrow transplants. In-a-word, this fellow reaped fairly impressive clinical improvements in lock-step with each of his treatments. Check it out: http://www.youtube.com/watch?v=FDeIhrBh12w How is a Whole Bone Marrow Transplant Done?

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Typically, Dr. Steenblock harvests bone marrow from either a patient's tibia (thick shin bone) or the iliac crest (hip bone). To do this he first deadens the area using a local anesthetic and then inserts a thinneedle attached to a large syringe. He then draws the bone marrow up into the syringe. Most patients report that the collection process is not especially painful or uncomfortable. The entire bone marrow harvesting and treatment process typically takes only a few hours [And this regardless of whether the collected bone marrow is infused by IV or lumbar puncture (intrathecal procedure) or direct injection.] Want to know more?

On-line : You can access a comprehensive handbook on Dr. Steenblock’s stem cell based program by clicking this link http://www.scribd.com/doc/44870565/Stemcellmd-Guidebook-2010-2011 or keying it in.

You can also call

Office: 1-949-367-8870

Toll Free: 1-800-300-1063

www.strokedoctor.com, www.stemcell.md 26381 Crown Valley Parkway Suite 130 Mission Viejo, CA. 92691

Dr. Steenblock’s Clinic – Home of Personalized Stem Cell Medicine

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