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An Arrow-shot Against Antismokers.

A study on lung cancer that brings disappointment to the
anti-smokers crusaders comes from the May 26 issue of
Archives of Internal Medicine, where it is reported a study of
Ping Yang, MD, professor of epidemiology at the Mayo Clinic, in
Rochester, Minnesota, regarding "Alpha1-Antitrypsin Deficiency
Carriers, Tobacco Smoke, Chronic Obstructive Pulmonary Disease,
and Lung Cancer Risk".
Dr. Yang and coll. analyzed the impact of alpha 1-antitrypsin
deficiency (AATD) in the incidence of pulmonary carcinoma and
found what I call an arrow-shot against the anti-smokers. That is:
AATD is a risk factor for the development of lung cancer
independently of the smoking status.
Such a concept is against the anti-tobacco activists who claim,
flaunt, propagandize that lung cancer is caused by cigarette smoke.

Alpha 1-antitrypsin is a protective protein produced by the liver.
Its functions is to protect the lungs from the neutrophil elastase
enzyme, which can disrupt connective tissue. Its deficiency is a
genetic disorder.
The study starts with the consideration that "Genetic susceptibility
in lung cancer risk has long been recognized but remains ill defined,
as does the role of tobacco smoke exposure and chronic obstructive
pulmonary disease (COPD)". The underlining is mine to point out
that in the scientific community there are (true) scientists who do
not mince words, clearly stating that the contention on lung cancer's
causes and risks in not all over, as the General Surgeon (& Co.)
wants people to believe.

In truth, dr. Yang did not make a discovery as it has always been
known that AATD causes lung disorders that comprise asthma,
emphysema, COPD and carcinoma. What I found interesting is the
fact that his study, indirectly points out that the above diseases are
not the hallmark of cigarette smoking, as the antismoking campaign
spreads far and wide.
From the study, that involved 1856 patients with incident lung
cancer, 1585 community residents as controls, and 902 full siblings
of the patients, came the confirmation of other studies (see:
Enstrom and Kabat, Jenkins, Boffetta, LeVois, Adlkofer, Lee - just to
mention a few):
Environmental tobacco smoke did not significantly increase the 
risk for lung cancer.

Such a statement hurts various institutions like, for example, the
American Lung Association, the Environmental Protection Agency, the
World Health Organization, which, influenced (led?) by the pharmaceutical
manufacturers, after the megaflop of their campaign to convince smokers
to give up their lifestyle, started to pester the non-smokers by putting in
their heads the hazy idea that the smoke blown out by the smoker, and
the one coming from the burning cigarette, lingers in the air they breathe
and, therefore, they and their children are going to get the same diseases
that, according to their propaganda, afflicts the smoker.

But everything comes to him who waits: society, slowly but certainly, is
understanding that the devil isn't as black as he's painted. People cannot
help but to notice that all that has been said about smokers' morbidity
and mortality, burdens every living soul, no matter wether they smoke or
not. The conclusion of dr. Yang that
"Among [AATD] carriers, the risk of developing lung cancer was  
similar regardless of smoking history" and that the risk is 70% higher 
than in non­carriers, puts another crack in their fabrication (see article).

The explanation of Dr. Yang is that, in the lungs, the noxious substances 
present in tobacco smoke, can be inactivated by the  defense mechanisms of 
the host himself. These adjustive reactions are hampered in individuals with 

According to the author, AATD carriers might have a risk of developing lung cancer 
that is 70% higher than that for non carriers.  The estimates of the World Health 
Organization, refer that it affects at least 10 million Americans and 120 million 
people worldwide. 

May I conclude with an advice to radical antismokers: Next time you want to 
flap the scarecrow of lung cancer from active and passive smoke, you better 
check the AATD status. since,

Alpha1­Antitrypsin Deficiency Carriers, Tobacco Smoke, Chronic Obstructive 
Pulmonary Disease, and Lung Cancer Risk
Cigarette smoke is especially harmful to individuals with A1AD
The deficiency can be passed on to kids from their parents, through genetic

It is important to avoid air pollution, smog, dust and, of course, smoke.

and that.

: "Among [AATD] carriers, the risk of developing lung cancer was similar  
regardless of smoking history". 

the body maintains a system of checks and balances on cell growth so that cells 
divide to produce new cells only when needed. Disruption of this system of checks 
and balances on cell growth results in an uncontrolled division and proliferation of 
cells that eventually forms a mass known as a tumor.
Ridiculous Study fresh sidestream cigarette smoke is approximately four
times more toxic than mainstream cigarette smoke!