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What is lupus? What are the types of lupus?

Lupus is an autoimmune disease characterized by acute and chronic inflammation of various
tissues of the body. Autoimmune diseases are illnesses that occur when the body's tissues are
attacked by its own immune system. The immune system is a complex system within the
body that is designed to fight infectious agents, such as bacteria and other foreign microbes.
One of the ways that the immune system fights infections is by producing antibodies that
bind to the microbes. People with lupus produce abnormal antibodies in their blood that
target tissues within their own body rather than foreign infectious agents. Because the
antibodies and accompanying cells of inflammation can affect tissues anywhere in the body,
lupus has the potential to affect a variety of areas. Sometimes lupus can cause disease of the
skin, heart, lungs, kidneys, joints, and/or nervous system. When only the skin is involved, the
condition is called lupus dermatitis or cutaneous lupus erythematosus. A form of lupus
dermatitis that can be isolated to the skin, without internal disease, is called discoid lupus.
When internal organs are involved, the condition is referred to as systemic lupus
erythematosus (SLE).
Both discoid and systemic lupus are more common in women than men (about eight times
more common). The disease can affect all ages but most commonly begins from 20-45 years
of age. Statistics demonstrate that lupus is somewhat more frequent in African Americans and
people of Chinese and Japanese descent.
What causes lupus? Is it hereditary?
The precise reason for the abnormal autoimmunity that causes lupus is not known. Inherited
genes, viruses, ultraviolet light, and certain medications may all play some role.
Genetic factors increase the tendency of developing autoimmune diseases, and autoimmune
diseases such as lupus, rheumatoid arthritis, and autoimmune thyroid disorders are more
common among relatives of people with lupus than the general population. Some scientists
believe that the immune system in lupus is more easily stimulated by external factors like
viruses or ultraviolet light. Sometimes, symptoms of lupus can be precipitated or aggravated
by only a brief period of sun exposure.
It also is known that some women with SLE can experience worsening of their symptoms
prior to their menstrual periods. This phenomenon, together with the female predominance of
SLE, suggests that female hormones play an important role in the expression of SLE. This
hormonal relationship is an active area of ongoing study by scientists.
More recently, research has demonstrated evidence that a key enzyme's failure to dispose of
dying cells may contribute the development of SLE. The enzyme, DNase1, normally
eliminates what is called "garbage DNA" and other cellular debris by chopping them into tiny
fragments for easier disposal. Researchers turned off the DNase1 gene in mice. The mice
appeared healthy at birth, but after six to eight months, the majority of mice without DNase1
showed signs of SLE. Thus, a genetic mutation in a gene that could disrupt the body's cellular
waste disposal may be involved in the initiation of SLE.

Lupus Symptoms in Women
One Patient's Story

and more pain in the form of pleurisy. skin. and d-penicillamine (used for rheumatoid arthritis). "I had no idea Susan was so sick.R. women. she was in pain. butterfly rash. isoniazid ([Nydrazid. The body's defenses actually attack healthy tissue. People with lupus have an overactive immune system. lupus myositis. not an infectious disease like HIV. more than 90% of cases of "drug-induced lupus" occurs as a side effect of one of the following six drugs: hydralazine (used for high blood pressure).By Mr. causing shortness of breath. Laniazid] used for tuberculosis). hereditary. phenytoin (used for epilepsy). D. This has been happening to Susan for 30 years or more. lupus nephritis What is drug-induced lupus? Dozens of medications have been reported to trigger SLE. there was no day that she didn't feel pain on an 8 to 10 level.) Lupus attacked her lungs. diagnosis. this is a good opportunity to clear things up. statistics. Lupus is an autoimmune disease. but she had symptoms way before then. sleeping problems. Fortunately. symptoms." That was because Susan did not want anybody to know. However. In 2000. On the scale of 1 to 10. From late in January 2000 until the day before she died. (With 10 being all-encompassing. lupus attacked her central nervous system and involved her brain. MD. kidney disease. with fatigue extending a month after every flare-up. anticoagulant. the disease would manifest itself as flu-like symptoms for about three weeks out of every three months. FACP. genetic. In addition to Hashimoto's thyroiditis (causing cold extremities) and Sjogren's syndrome (extremely dry eyes) and a few more isms that I have forgotten. discoid lupus. These drugs are known to stimulate the immune system and cause SLE. Read on as Susan battles lupus » Top Searched Lupus Terms: lupus disease. Medical Editor: William C. drug-induced SLE is infrequent (accounting for less than 5% of all people with SLE) and usually resolves when the medications are discontinued. diet. FACR So many people have had comments like. treatment. Originally. Because lupus is such a crafty disease and flies under the general public's radar.. contagious. rash. The original result of this new development was pain. She was diagnosed around 1990. Shiel Jr. quinidine and procainamide (used for abnormal heart rhythms). What are the symptoms and signs of lupus? . life was getting difficult.

wrists. Complications of organ involvement can lead to further symptoms that depend on the organ affected and severity of the disease. Skin manifestations are frequent in lupus and can sometimes lead to scarring. White blood cells and blood-clotting factors also can be characteristically decreased in SLE. and feet. flat facial rash over the bridge of their nose. Most people with SLE will develop arthritis during the course of their illness. called a "flare" of the disease. It usually is red and may have raised borders. with treatment. Inflammation of blood vessels (vasculitis) that supply oxygen to tissues can cause isolated injury to a nerve. The blood vessels are composed of arteries that pass oxygen-rich blood to the tissues of the body and veins that return oxygen-depleted blood from the tissues to the lungs. Arthritis in SLE commonly involves swelling. More serious organ involvement with inflammation occurs in the brain. and even deformity of the small joints of the hands. loss of appetite. In discoid lupus. ulcers of the mouth and nose. a condition called photosensitivity. pain. The rash is painless and does not itch. liver. Discoid lupus rashes are usually painless and do not itch. the skin. The damage blocks the circulation of blood through the vessels and can cause injury to the tissues that are supplied with oxygen by these vessels. This can lead to elevations of muscle enzyme levels in the blood. Inflammation of muscles (myositis) can cause muscle pain and weakness. Leukopenia can increase the risk of infection and thrombocytopenia can increase the risk of bleeding. respectively. Vasculitis is characterized by inflammation with damage to the walls of various blood vessels. Common complaints and symptoms include fatigue. . 5%-10% of those with discoid lupus may develop SLE. only the skin is typically involved. it is frequently referred to as the "butterfly rash" of SLE. Over half of the people with SLE develop a characteristic red. Typically. but scarring can cause permanent hair loss (alopecia). This photosensitivity can be accompanied by worsening of inflammation throughout the body.People with SLE can develop different combinations of symptoms and organ involvement. and kidneys. arthritis. can be precipitated or worsened by exposure to sunlight. and poor circulation to the fingers and toes with cold exposure (Raynaud's phenomenon). inflammation of the lining that surrounds the lungs (pleuritis) and the heart (pericarditis). or an internal organ. Over time. Because of its shape. along with inflammation in other organs. The facial rash. this rash can heal without permanent scarring. known as leukopenia (leucopenia) and thrombocytopenia. stiffness. The skin rash in discoid lupus often is found on the face and scalp. low-grade fever. muscle aches. the arthritis of SLE can mimic that of rheumatoid arthritis (another autoimmune disease). Sometimes. unusual sensitivity to sunlight (photosensitivity). facial rash ("butterfly rash").

Brain involvement is referred to as lupus cerebritis. seizures. causing blanching. the blood supply to the fingers and/or toes becomes compromised upon exposure to cold. Damage to nerves can cause numbness. kini merasa plong dalam menjalani hidupnya. saya harus menggantikan energi saya dengan tidur selama 3 hari. It has also been shown that young women with SLE have a significantly increased risk of heart attacks due to coronary artery disease. nutrisi dan lainnya untuk tubuh. Pengobatan Alternatif untuk Penyakit Lupus Sumarmi Nur Jl. and even kidney failure. Some people with SLE have Raynaud's phenomenon. high blood pressure. With kidney failure. begitu ia dipanggil terhadap penyakit Lupus yang diderita. and weakness of the involved body parts or extremities. This can lead to further fatigue and swelling of the legs and feet. fluid retention. Often. 2008By: noniblog Category: Lupus Dara manis bernama Ruthia Pasaribu. 21 Tahun. tingling. Bahkan jika harus beraktifitas selama 24 jam pun ia tidak akan keberatan.Inflammation of the lining of the lungs (pleuritis) and of the heart (pericarditis) can cause sharp chest pain. Lama kelamaan lebam tersebut semakin banyak dan terasa sakit. and certain changes in body position. Mulanya tubuh Ruth timbul lebam. The heart muscle itself rarely can become inflamed (carditis). In this condition. Many people with SLE experience hair loss (alopecia).” cerita Ruth. Avia 200 Kwadengan Depan GOR Sidoarjo HP : 081809809073 Flexi : 031-72837265 Home :031-8940329 BAHRUDIN SE HP : 081233762859 May 14. karena imunitas tubuhnya sudah kembali normal. Juli 2006 menjadi awal penderitaan Ruth. Involvement of the brain can cause personality changes. The chest pain is aggravated by coughing. this occurs simultaneously with an increase in the activity of their disease. thought disorders (psychosis). deep breathing. Ruth merasa tubuhnya semakin lama semakin melemah. Padahal ia sudah memenuhi kebutuhan gizi. The hair loss can be patchy or diffuse and appear to be more like hair thinning. Ia malah merasa lebih kuat dari sebelumnya. and pain and numbness in the exposed fingers and toes. Kidney inflammation in SLE can cause leakage of protein into the urine. and even coma. . Anehnya lagi. whitish and/or bluish discoloration. machines are needed to cleanse the blood of accumulated waste products in a process called dialysis. “Jika saya beraktifitas selama 4 jam.

Tak ingin memperparah kondisi dengan meminum steroid. Ia sudah bisa kembali beraktifitas. malah berbalik menyerang dirinya sendiri. Tapi melihat kondisi mamanya yang menderita sakit ginjal dan jantung bisa sembuh. Sampai akhirnya doa untuk kesembuhan putrinya terkabul dengan diperkenalkannya Ruth dengan Tahitian Noni Juice (TNJ). Ruth mencoba meminumnya. diduga berhubungan dengan genetik. Berbahayakah Penyakit Lupus ? oleh: handoyo Pengarang : handoyo More About : penyakit lupus Berbahayakah Pe Penyakit lupus belum begitu dikenal luas di masyarakat Indonesia dan sampai saat ini belum mendapat perhatian khusus dari pemerintah meskipun diperkirakan jumlah penderita lupus ( odapus ) terus bertambah. Beberapa ciri gejala lupus antara lain rasa lemas. dalam waktu 3 minggu. Artinya sistem imun membentuk antibodi yang seharusnya bekerja memerangi infeksi yang disebut antigen seperti bakteri. “Obat itu adalah mesin pembunuh jangka panjang.capek yang berlebihan. Ia lalu mengalami depresi berat dengan kondisi tubuhnya. ruam merah di kulit yang umumnya lebih nyata bila terpapar sinar matahari. steroid mengembalikan vitalitas Ruth. bisa di susunan syaraf. Terima kasih TNJ. Kelainan yang ditimbulkan bisa berupa nyeri. Benar saja. jamur atau zat – zat asing yang masuk ke dalam tubuh. Ruth memilih berbaring di rumah. tergantung bagian tubuh yang diserang.demam berkepanjangan. Pada abad 13 dokter Rogerius menggunakan istilah lupus untuk menggambarkan lesi di hidung dan wajah penderita yang menyerupai gigitan serigala. .sinar ultraviolet dan obat-obatan tertentu. Derita Ruth membuat sang mama merasa miris akan kondisinya.virus.kulit maupun sendi. “Tuhan mengabulkan doa saya atas kesembuhan dan merayakan natal tahun ini bersama keluarga.ruam merah di wajah yang menyerupai gambar kupu-kupu. sayangnya steroid berimbas pada kerapuhan pada tulang untuk jangka lama. dalam sebulan imunitas Ruth kembali seperti semula. Penyebab penyakit lupus sampai sekarang belum diketahui secara pasti. Penyakit lupus tergolong penyakit autoimun. Sistem imun ini kehilangan kemampuan untuk membedakan yang mana antigen asing dan mana sel atau jaringan tubuhnya sendiri. paru – paru.jantung.ataupun kerusakan jaringan. Istilah lupus berasal dari serigala.” katanya.Medis mendiagnosa bahwa ini adalah gejala Lupus. Satu satunya penakluk adalah steroid.virus. penyakit yang menyerang imunitas tubuh. akibatnya antibodi yang terbentuk menyerang sel atau jaringan tubuh sendiri dan menyebabkan berbagai kelainan. Awalnya Ruth tidak mau karena harganya mahal dan ia pesimistis dengan hasilnya.ginjal. Benar saja.peradangan.

Antibodi anti nuklear serta beberapa jenis antibodi dapat diperiksa untuk mendukung diagnosis lupus. Istilahnya disebut LES atau Lupus. di dunia terdeteksi penyandang penyakit Lupus mencapai 5 juta orang. Tidak sedikit pengindap penyakit ini tidak tertolong lagi. serta pemeriksaan urin untuk mendeteksi adanya gangguan ginjal. Pemeriksaan laboratorium diperlukan untuk mendeteksi kelainan lupus yang melibatkan sel-sel darah. Bercak-bercak merah di bagian wajah dan lengan. Kulit yang mudah gosong akibat sinar matahari serta timbulnya gangguan pencernaan. rambutnya rontok. tetapi juga dapat menyerang hampir seluruh organ yang ada di dalam tubuh. sedangkan pada masa remisi (nonaktif) menghilang. demam dan pegal-pegal. Eritomatosus artinya kemerahan. lebih dari 100 ribu kasus baru terjadi setiap tahunnya. Awalnya. Gejala Penyakit Lupus.sariawan yang berulang. penderita penyakit ini dikira mempunyai kelainan kulit. serta pemeriksaan urin untuk mendeteksi kelainan lupus yang melibatkan sel-sel darah. Arti kata lupus sendiri dalam bahasa Latin berarti “anjing hutan”. kelelahan yang berlebihan. Kadang disebut (butterfly rash). Penyakit ini tidak hanya menyerang kulit. akan muncul ruam merah yang membentang di kedua pipi. Gejala-gejala penyakit dikenal sebagai Lupus Eritomatosus Sistemik (LES) alias Lupus. Gejala ini terutama didapatkan pada masa aktif. Namun ruam merah menyerupai cakram bisa . berupa kemerahan di sekitar hidung dan pipi . 2.ruam diskoid. panas dan rasa lelah berkepanjangan . rambut rontok.nyeri pada sendi dan bengkak pada kedua tungkai. mirip kupu- kupu. Gejala umumnya penderita sering merasa lemah. Gejala-gejala yang umum dijumpai adalah: 1. Istilah ini mulai dikenal sekitar satu abad lalu. persendian kerap bengkak dan timbul sariawan. Gangguan neurologik maupun psikiatrik juga dapat terjadi pada penderita lupus. 3. Ciri Penyakit Lupus" Obat Herbal Lupus Penyakit Lupus adalah penyakit baru yang mematikan setara dengan kanker. Pada kulit. sedangkan sistemik bermakna menyebar luas keberbagai organ tubuh. Lebih lanjut tentang: Berbahayakah Penyakit Lupus ? "Perihal Penyakit Lupus.

dan stres.” ujarnya. antibodi bisa bergabung dengan antigen (zat perangsang pembentukan antibodi). kompleks ini akan dibatasi oleh sel-sel radang (fagosit) Tetapi.Gabungan antibodi dan antigen mengalir bersama darah. Hasilnya. ginjal. otak. kompleks ini tidak dapat dibatasi dengan baik. Hasilnya. menonjol dan kadang-kadang bersisik. terkena paparan sinar matahari. Timbulnya penyakit ini karena adanya faktor kepekaan dan faktor pencetus yaitu adanya infeksi. Rahmat Gunadi dari Fak. muncul di kulit seluruh tubuh. maka dalam jangka panjang fungsi organ tubuh akan terganggu. Kalau hal ini terjadi. keluarga Odapus. antibodi aneh ini bisa langsung menyerang jaringan sel tubuh. sampai tersangkut di pembuluh darah kapiler akan menimbulkan peradangan. Melihat banyaknya gejala penyakit ini. Dan tentu saja. Namun. terutama pada usia 15-40 tahun.000 penduduk. paru-paru. 4. Penyakit ini justru kebanyakaan diderita wanita usia produktif sampai usia 50 tahun sekalipun ada juga pria yang mengalaminya. penyakit Lupus ini antibodi yang terbentuk dalam tubuh muncul berlebihan. Uniknya. dalam penyakit ini kekebalan tubuh justru menyerang organ tubuh yang sehat. otot. bersifat genetik. Kedokteran Unpad/RSHS menjelaskan. sering diduga berkaitan dengan kehamilan yang menyebabkan abortus. tulang. Selanjutnya. Oleh karena itu dianggap diduga penyakit ini berhubungan dengan hormon estrogen. Inilah yang mengakibatkan penderitanya kekurangan sel darah merah atau anemia. “Penyakit ini dapat mengenai semua lapisan masyarakat. Bangsa Afrika dan Asia lebih rentan dibandingkan kulit putih. . Tetapi hal yang berkebalikan juga mungkin atau bahkan memperburuk geja LUPUS. Dalam tubuh seseorang terdapat antibodi yang berfungsi menyerang sumber penyakit yang akan masuk dalam tubuh. maka wanita yang sudah terserang dua atau lebih gejala saja. proses peradangan akan berkepanjangan dan akan merusak organ tubuh dan mengganggu fungsinya. dalam keadaan abnormal. Wanita lebih sering 6-10 kali daripada pria. hati. pemakaian pil KB. 1-5 orang di antara 100. Tubuh memiliki kekebalan untuk menyerang penyakit dan menjaga tetap sehat. Kelainan ini disebut autoimunitas . pemakaian obat-obatan. membentuk ikatan yang disebut kompleks imun. Sering dijumpai gejala Lupus muncul sewaktu hamil atau setelah melahirkan. gangguan perkembangan janin atau pun bayi meninggal saat lahir. Antibodi yang berlebihan ini. bisa masuk ke seluruh jaringan dengan dua cara yaitu : • Pertama. Reaksi sistem imunitas bisa mengenai berbagai sistem organ tubuh seperti jaringan kulit. sistem saraf. Dalam keadaan normal. hal ini akan terlihat sebagai gejala penyakit. Pada kehamilan dari perempuan yang menderita lupus. Anemia yang diakibatkan oleh sel-sel darah merah yang dihancurkan oleh penyakit LUPUS ini 5. yang menimbulkan peradangan di sekitar kompleks. sistem pencernaan. lapisan pada paru-paru. harus dicurigai mengidap Lupus. Malah sel-sel radang tadi bertambah banyak sambil mengeluarkan enzim. antibodi justru menyerang sel-sel jaringan organ tubuh yang sehat. maupun pembuluh darah dan sel-sel darah. dapat diturunkan. • Kedua. mata. seperti pada sel-sel darah merah yang menyebabkan selnya akan hancur. penyakit lupus adalah penyakit sistem imunitas di mana jaringan dalam tubuh dianggap benda asing. sistem kardiovaskuler. Rambut yang sering rontok dan rasa lelah yang berlebihan Dr. Penyakit Lupus diduga berkaitan dengan sistem imunologi yang berlebih.

Source : http://doktersehat. tampaknya sulit.com/2007/09/24/lupus-apa-itu-penyakit-lupus/ .Lebih difokuskan untuk mencegah meluasnya penyakit dan tidak menyerang organ vital tubuh.Kesembuhan total dari penyakit ini. Dokter lebih berfokus pada pengobatan yang sifatnya sementara.