Curriculum Vitae

Dr. Anand Mohan Jha

OFFICIAL ADDRESS

Reader & Co-ordinator

Department of Biotechnology
Samastipur College (Post- Graduate), Samastipur- 848 134, India
(Under L. N. Mithila University,Kameshwarnagar,Darbhanga, India)

RESIDENTIAL DDRESS

Professor Colony, Bahadurpur,

Samastipur- 848101, India
Phone No. +916274223078 (R)
Mobile No. +919431425273
Mobile No. +919939699549
Email:-dranandmjha@yahoo.com

Date of Birth: 22.nd January 1957

CAREER OBJECTIVES

 Teaching and Research

 To acquire knowledge about recent developments taking place in the field of biotechnology and
disseminate these among the students
 To make efforts for bringing the name of institution at International arena. by doing research
in the field of Genetic Toxicology and Environmental Mutagenesis
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EDUCATIONAL QUALIFICATION

Ph. D. Mutagenesis
Title of Thesis Induction and Isolation of Mutants in French bean (Phaseolus vulgaris L.)
University Bihar University, Muzaffarpur
Year of Award 1986

Post-graduate Master of Science in BOTANY

Specialisation Cytogenetics and Plant Breeding
University L. N. Mithila University, Kameshwar Nagar, Darbhanga - 846004
Year 1978
Class First
Percentage of Marks 66.66%

Graduation Botany Hons.

University L. N. Mithila University, Kameshwar Nagar, Darbhanga - 846004
Year 1976
Class Second
Percentage of Marks 57.33%

Under- Graduation Intermediate Science

University L. N. Mithila University, Kameshwar Nagar, Darbhanga - 846004
Year 1974
Division First
Percentage of Marks 60.33%

Secondary
Board Bihar School Examination Board, Patna
Year 1972
Division First
Percentage of Marks 66.33%

TEACHING EXPERIENCE
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Under-Graduate More than 25 Years

Post Graduate More than 23 Years

 Experience of teaching student of Botany Stream up to Post-graduate level from 1983

 Experience of teaching students of Biotechnology stream (B.Sc. Honors Level) from 1999

Botany stream: Plant physiology, Cytogenetics, Molecular biology,Biotechnology

Molecular Biology. Genetics, Plant Biotechnology, Recombinant
Biotechnology stream DNA Technology

DISTINCTIONS ACHIEVED

2. Fellow Indian Society of Genetics and Plant Breeding

3. Life Member Environmental Mutagen Society of India
4. Member of Editorial Board of the following International Journals
1. International Journal of Botany- Technical Editor
2. Asian Journal of Scientific Research- Technical Editor
3. Research Journal of Mutagenesis- Technical Editor
4. Research Journal of Environmental Toxicology- Associate Editor
5. Research Journal of Environmental Science- Associate Editor
5. Reviewer of Research Papers submitted for Publication in many International journals such as
Mutation Rssearch (Genetic Toxicology and Environmental Mutagenesis), Elsevier Publication
International Journal of Botany, International Journal of Biotechnology, Pakistan Journal of Biological
Science, ANSI Journals, www.sci@alert.com

ADMINISTRATIVE EXPERIENCE

Coordinator, Vocational Course in Biotechnology from May 1999- April 2003 and again from
April 2006

PARTICIPATION IN TRAINING & SHORT TERM COURSES

 Participated in Short ter course and Training in Microbiol Biotechnology and Application
at Centre of Relevance and Excellence in Agro and Industrial Biotechnology (TIFAC-CORE)
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Thapar Institute of Engineering and Technology, Patiala

 Paticipated in U.G.C. sponsored INFLIBNET Awareness Programme for the Colleges of

Bihar and Jharkhand at St. Xavier College, Ranchi

 Participated in Short term training on Genotoxicity Biomarkers in Fishes, at National

Bureau of Fish Genetic Resource (NBFGR), Lucknow

RESEARCH ACTIVITIES

Area of Specialization: Genetic Toxicology & Chemical Mutagenesis

Research scholars who have successfully completed their research leading to the
Award of Ph.D. degree

1 Dr. S. F. Rab 1993 Cytogenetic Activity of Some Agrochemicals on Vicia faba L.

2 Dr. A. K. Sinha 1996 Mutation Induction for Improved Yield and Oil Content in Indian
Mustard (Brassica juncea Czern and Coss)
3 Dr. A. C. Singh 1997 Studies on Mutagenic / Carcinogenic Properties of Some Metallic
Compounds
4 Dr. M. Bharti 2000 Assessment of Genotoxic Potential of Some Industrial chemicals
in vivo in mice
5 Dr. A. Haque 2002 Recurrent Mutagenesis in Indian Mustard ( Brassica juncea
Czern & Coss.
6 Dr. M. Kumar 2008 Mutagenicity of alpha and beta unsaturated aldehydesin mouse in vivo

Research scholars who are registered for Ph.D. degree

1 Ragni 2005 Investigation on Cytogenetical and morphological effects of Arsenic

in the irrigation water in agricultural crops,
2 L. K. Ghosh 2005 Exploring the genotoxicity of soil contaminants by employing plant
chromosomal aberration assay.
3 S. N. Jha 2006 Assessment of Genotoxicity of some heavy metals
4 J. Choudhary 2007 Assessment of Genetic Effects Of Some Heavy Metals In
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Freshwater Teleost (Channa punctatus)

Research Projects Undertaken/ Ongoing

1 Biochemical Changes induced by Effluents in Plants. Supported and Financed by

U.G.C., New Delhi Grant No. F-8-1 (48)/87 (SR II) (Completed)

2 Mammalian Germ Cell Genotoxicity Of , Unsaturated Aldehydes 2-trans-butenal, 2-

trans hexanal and 2-trans, 6-cis-nonadienal and Human Risk Assessment. Supported and
Financed by U.G.C., New Delhi Grant No. F. No. 3- 121/ 2001 (SR-II), Completed

3 Multi-end point Analysis of Genetic Damage Induced by Arsenic in Mammalian Germ

Cells. Supported and Financed by U.G.C., New Delhi Grant No. F. No. 32- 566/ 2006 (SR),
(ongoing)

Publications

Text Books

1. Comprehensive Aadhunik Vanaspati Shastra for Intermediate Students ; Laxmi Publication

(Pvt.) Ltd., New Delhi

2. Comprehensive Paryavaran Adhayan (Hindi) for Class IX of BSEB, Patna ; Laxmi Publication
(Pvt.) Ltd., New Delhi

3. Comprehensive Paryavaran Adhayan (Hindi) for Class X of BSEB, Patna; Laxmi Publication
(Pvt.) Ltd., New Delhi

4. Comprehensive Biology (Hindi) for Class XI Laxmi Publications (Pvt.) Ltd., New Delhi (in Press).

PUBLICATIONS

1. Anand M. Jha, Akhilesh C. Singh, Uma Sinha and Mithilesh Kumar 2007
Genotoxicity of Crotonaldehyde in the Bone marrow and Germ cells of Laboratory mice,
Mutation Rssearch (Genetic Toxicology and Environmental Mutagenesis) , Elsevier, Ireland,
632(1-2), 69-77. .
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2. Anand M. Jha and Mithilesh Kumar 2006 In vivo evaluation of induction of

abnormal sperm morphology in mice by an unsaturated aldehyde crotonaldehyde, Mutation
Rssearch (Genetic Toxicology and Environmental Mutagenesis) , Elsevier, Ireland , 603 (2),
159-163.
3. Akhilesh C. Singh, Mithilesh Kumar and Anand M. Jha 2003 Genotoxicity of
lomefloxacin an antibacterial drug in somatic and germ cells of Swiss albino mice in vivo.
Mutation Rssearch (Genetic Toxicology and Environmental Mutagenesis, Elsevier Publiction,
Ireland) , 535, 35- 42
4. A. M. Jha, Akhilesh C. Singh and Mithilesh K. Bharti 2002 Clastogenicity of
carbazole in mouse bone marrow cells in vivo. Mutation Research (Genetic Toxicology and
Environmental Mutagenesis, Elsevier Publiction, Ireland) , 521, 11- 17.
5. Jha A. M. and M. K. Bharti 2002 Mutagenic profiles of carbazole in the male germ
cells of Swiss albino mice. Mutation Research (Genetic Toxicology and Environmental
Mutagenesis), Elsevier Publiction, Ireland) , 500, 97- 101
6. Jha, A.M. and Singh, A. C and M. Bharti 1998 Germ cell Mutagenicity of
Phthalic acid esters in mice . Mutation Research (Fundamental and Molecular Mechanism
of Mutagenesis, Elsevier Publiction, Ireland) 422, 207 - 212.
7. Singh, A.C. Rashmi B. Pandey, Bharti, M. and Jha, A.M. 1997 Cytological effects
of two rare earth compounds on the root tip cells of Vicia faba L. J. Environ. Biol. 18
,27 - 31.
8. Jha, A. M., Rab, S.F. and Singh, A.C. 1996 Cytotoxic activities of three herbicides
in root tip cells of Vicia faba L.. J. Environ Biol. 17, 211- 216.
9. Jha, A.M. and Singh, A.C.1995 Clastogenicity of Lanthenides :Induction of
chromosomal aberrations in bone marrow cells of mice in vivo. Mutation Research ( Genetic
Toxicol. Testing ) 341, 193 - 197.
10. Jha, A. M., Singh, A. C., Jha, N. K. and Rashmi 1994 Cytological effects of
water extract of Moringa olefera on Vicia root tip cells. J. Cytol. Genet. 29, 97 -100.
11 Jha, A. M. and Singh, A. C.1994 Clastogenicity of lanthenides:Induction of
micronuclei in root tips of Vicia faba. Mutation Research (GenetIc Toxicology Testing,
Elsevier Publiction, Ireland) 322, 169-172
12. Jha, A. M. and Sinha, A. K. 1994 Induction of chlorophyll mutations in
Brassica juncea Czern & Coss. Acta Botanica Indica 22, 57 - 62.
13 Jha, A. M. and Rab, S. F. 1994 Mitodepressive and chromotoxic effects of
herbicides in Vicia faba Acta Botanica Indica 22, 159 - 160.
14. Singh, A.C., Rashmi and Jha, A.M. 1994 Mitodepressive and clastogenic effects of
rare earth compouds in plant system . J. Cytol. Genet. 29, 205 - 207
15. Prasad, A. B. and Jha, A. M. 1993 Induced variability for seed yield and seed
protein in french bean ( Phaseolus vulgaris L.). J. Cytol. Genet. 28, 31 - 34.
16. Prasad, A. B. and Jha, A. M. 1993 Induced variability for seed protein in french bean
( Phaseolus vulgaris L.). Bioved 4, 121 - 124.
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17. Jha, A. M. and Sinha, A. K. 1992 EMS and sodium azide induced biological damage
in Brassica juncea var. krishna. Acta Botanica Indica 20, 152- 155.
18. Prasad, A. B.and Jha, A. M. 1992 Mutation affecting seed coat colour and seed
protein in french bean ( Phaseolus vulgaris L.) . J. Cytol. & Genet. 27, 147- 152.
19. Prasad, A. B. and Jha, A. M. 1989 Laminar genetic disorder induced by gamma rays
in different varieties of Phaseolus vulgaris L. J. Ind. Bot. Soc. 68, 241 - 243.
20. Jha, A. M. 1989 Mutagenic effects of cephalexin and sodium azide alone and
in combination in Barley (Hordeum vulgare). J. Cytol. Genet. 24, 124- 127.
21. Prasad, A. B., Jha, A.M. and Rashmi 1988 A comparative assessment of
radiosensitivity in french bean. J. Cytol. Genet. 25, 140 - 146.
22. Jha, A.M. 1988 Studies on the induced seedling mutants in Phaseolus vulgaris L
Acta Botanica Indica 16, 28- 30.
23. Prasad, A.B., Verma, M.P. and Jha, A.M. 1986 Seed protein content and protein
pattern in gamma ray induced Phaseolus mutants In: Mutagenesis: Basic and Applied
(Proc. Symp. XV Intern. Cong. Genet. Sat. Symp. ) Print House, Lucknow pp. 159- 184.
24. Rab, S.F., Jha, A.M. and Shrivastava, A.K. 1986 Ceratocystis fimbriata on
mango.Indian Phytopath., 32, 176.
25. Prasad, A .B., Verma, M. P. and Jha, A. M. 1986 Gamma ray induced
Chlorophyll mutation in five varieties of Phaseolus vulgaris L. Acta Botanica Indica 14(spl)
65 -72
26. Prasad, A. B, Verma, M.P. and Jha, A.M. 1984 Seed coat colour as a marker for
higher Protein content in Phaseolus vukgaris L. var. Giant Stringless. In: Recent Trends in
Botanical Research ( ed. R.N.Gohil), Scientific Publishers, Jodhpur, pp. 278 - 287.
Abstracts/ Paper Presented in Seminars/Symposia etc.
27. Prasad, A B., Verma, M. P., Prasad. P. R. and Jha, A.M. 1980 Varietal response to
gamma rays in five varieties of French bean. All India Botanical Congress, Abst pp. 116
28. Prasad, A B., Verma, M.P. and Jha, A.M. 1981 Comparative studies of chlorophyll
mutations in five varieties of French bean. All India Congress Cytologists and Geneticists, Abst
pp. 136
29. Prasad, A B, Verma, M.P. and Jha, A.M. 1982 Laminar Genetic disorder induced by
different group of mutagens. Indo- US Seminar on the Effects of Environmental Agents on
Genetical System, University of Calcutta, Calcutta, Abst. pp.3.
30. Prasad, A B, Verma, M.P. and Jha, A.M. 1982 Seed coat colour as a marker for
higher protein content in Phaseolus vulgaris L. var. Giant stringless. New Approaches in Plant
Science Research, Abst pp. 21
31. Prasad, A B, Verma, M.P. and Jha, A.M. 1983 Status of protein in five different
varieties of Phaseolus vulgaris L. 1983 Indian Science Congress, Abs. pp. 106
32. Prasad, A B, Verma, M.P. and Jha, A.M. 1983 Modification by mutation of Protein
quality and quantity. Abst. XV International Congress of Genetics, New Delhi , 1983 pp. 483
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33. Prasad, A B, Verma, M.P. and Jha, A.M. 1983 Seed protein content and protein
pattern in gamma ray induced Phaseolus mutants. International Congress of Genetics: Satellite
Symp on Mutgenesis : Basic and Applied, Abst. pp. 23 - 23
34.Jha, A.M. and Rab, S.F. 1990 Cytological effects of herbicides on root meristem of
Vicia faba 1990 L. A. I. C. Cytologists and Geneticists, pp. 23-24
35. Jha, A.M. and Sinha, A. K. 1990 Induced variability for quantitative traits in Indian
mustard. 1990 A. I. C. Cytologists and Geneticists, Nagpur University, Nagpur, pp. 24.
36. Jha, A.M. Singh, A. C. and Pandey, R 1994 Genotoxic effects of strontium
chloride on root meristem of Allium cepa L. 1994 National Symposium Genes and Human
Environment, 1994.
37. Jha, A.M. and Singh, A. C. 1994 Clastogenic effects of lanthanides- induction of
micronuclei in root tips of Vicia faba L. 1994 National Symposium Genes and Human
Environment, 1994.
38. Jha, A.M. and Singh, A. C. 1994 Clastogenic effects of rare earth compounds in
mouse in vivo. 1994 National Symposium Genes and Human Environment, Hyderabad, 1994.
39. Jha, A.M. Singh, A. C. and Jha, N. K. 1994 Terminalia fruit extract induced
clastogenic adaptation in root meristem of Vicia faba L. 1994. National Symposium Genes and
Human Environment, 1994.
40. Jha, A.M. Singh, A. C. Prasad, A.B. 2002 Genotoxicity of lomefloxacin- an
antibacterial drug in somatic and germ cells of Swiss albino mice in vivo. The National Academy
of Sciences, India, Abstract,19- 20
41. Jha, A.M. Singh, A. C. and Mithilesh Kumar 2003 Germ Cell Mutagenicity of
crotonaldehyde - an unsaturated aldehyde in mice. Environmental Mutagen Society of India
Abstract, 76-77.
42.. Bibiliography on Environmental Mutagens ( Work done by Indian workers)
Published & Released by Department of Botany, L. N. Mithila University, Darbhanga during XV
International Congress of Genetics post Satellite Symposium on Mutagenesis : Basic And
Applied, Dec 22- 23, 1983
43. Improvement of Protein Quantity and Quality in Beans, Technical Report U. G. C.
Major Research Project ( F 23- 1118/ 79 ( SR II) pp. 101.
44. Monoclonal Antibodies & their applications. Published in Hindustan Times in
Competitive Edge, May 2000.
45. Application of Genetic Engineering: Published in special issue of Bharti- a magazine
of Samastipur College, Samastipur.2005, pp. 8-10
46. Pramukh Paryavarniya Sankat (in Hindi): Published in special issue of “Bharti” - a
magazine of Samastipur College, Samastipur.2005, pp. 1-8 (Hindi section).

Summary of Important Research Findings Published in International and

National Journals of Repute
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1. Clastogenic and mutagenic properties of three herbicides viz. Butachlor, Fluchloralin

and Benthiocarb were evaluated in the root meristem, flower buds and morphological and many
agronomic traits of Vicia faba L.

2. Chemical mutagens like EMS and Sodium azide were employed to induce mutations
for agronomic traits and oil content in in Indian Mustard (Brassica juncea)..

3. Mutagenic and carcinogenic properties of metallic compounds (lanthanides) were

studied in plants and animal models and clastogenic properties of lanthanide compounds in plant
and animals were reported for the first from our laboratory. The report has been published in
an International Journal Mutation Research ( Genetic Toxicol. Testing, , Elsevier Publiction,
Ireland ).

4. Genotoxic and mutagenic potentials of industrial chemicals viz. Pthalic acid and
carbazole were evaluated in vivo in mice. We have reported that pthalic acid and carbazole are
genotoxic and mutagenic for animals in vivo. The results were published in an International
Journal Mutation Research (Genetic Toxicol. Testing) and Mutation Research (Fundamental
and Molecular Mechanism of Mutagenesis, Elsevier Publiction, Ireland) , 500, 97- 101

5. Recurrent Mutagenesis was successfully employed for inducing mutants with

quantitative and qualitative changes in oil content in Indian Mustard ( Brassica juncea Czern &
Coss) by the use of gamma rays and EMS..

6. Evaluation of somatic and germ cell clastogenicity and mutagenicity of alpha and beta
unsaturated aldehydes (2-Alkanals) has been undertaken as a major research project keeping in
view ubiquitous nature of these organic compounds. The three test chemicals viz. 2-trans
butenal, 2-trans hexenal and 2-trans, 6-cis nonadienal induced chromosomal aberrations in the
bone marrow cells and also in the germ cells and stage specific dominant lethal mutations as well
as high frequency of abnormal sperm heads. Although they have failed to induce higher
frequency of heritable chromosomal changes i.e. translocations. The reproductive profile
observed in the dominant lethal experiment demonstrates similarity in the effect of these three
structurally and functionally related compounds in male germ cells. The primary reproductive
effect recorded for these chemicals was induction of dominant lethal mutation resulting in the
significant reduction in the number of offspring. The ratio of dominant lethal mutation to
heritable translocation has been shown to be dependent upon the nature of chemical mutagens
and the stage of post-meiotic germ cells affected. In the present investigation with a and b-
unsaturated aldehydes higher incidence of dominant lethals were induced in early to late
spermatids and testicular sperm but the corresponding frequencies of heritable translocations
were much lower. Finally, the human genetic hazards posed by the three alpha and beta
unsaturated aldehydes are almost identical.

On the basis of the results of the present investigation it may be concluded that the alpha
and beta unsaturated aldehydes viz. 2-trans butenal, 2-trans hexenal and 2-trans, 6-cis nonadienal
are mutagenic in the germ cells of mammals. The research finding has been published in
Mutation Rssearch (Genetic Toxicology and Environmental Mutagenesis) , Elsevier, Ireland ,
603 (2), 159-163(2006) and 632(1-2) 2007, 69-77.
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Other Experience

1. Experience of handling sophisticated instruments like PCR, HPLC, GLC, AAS,

Fluorescence Microscope, PAGE, UV- Vis Spectrophotometer etc.
2. Practical experience of PAGE Protein analyses, RFLP, Comet assay, Chromosome aberration
assay in Plant and Animal models etc

Dr. Anand Mohan Jha