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By Lorelai Brunner

Possible Links Between Blood Types


and COVID-19 Infection

What is Blood Type:


Original Data From The American Red Cross--Facts About Blood and Blood Types

A B AB O
Rh + Rh - Rh + Rh - Rh+ Rh - Rh + Rh -

Has A antigens in the red Has B antigens in the red Has A and B antigens in Has no A or B antigens in
cells, and B antibodies in cells, and A antibodies in the red cells, and no A or B the red cells, but A and B
the plasma the plasma antibodies in the plasma antibodies in the plasma

The Current Data:

2005 SARS-CoV-1 Blood Type Study:


The SARS-CoV-1 virus showed a connection between A antibodies found in blood types B and O. The A antibodies bind to SARS-
CoV-1 spike proteins, instead of the spike proteins binding to ACE2 receptors that cause infection. Leaving blood types B and
O to have less of a chance to get the virus, compared to blood types A and AB.

Blood Type A & AB Blood Type O & B


Appeared to be More Vulnerable To The Appeared to be Less Vulnerable To The
Virus: Virus:

Doesn't have A antibodies Has A antibodies


Appeared to exhibit greater severity Appeared to exhibit less severity in
in symptoms symptoms
Overall longer intensive care unit Overall shorter intensive care unit
(ICU) stay (ICU) stay
Higher need for ventilators Lesser need for ventilators
More needed dialysis for kidney Less needed dialysis for kidney
failure failure
Most studies more tested positive Most studies less tested positive

Diagram from Siemens Healthineers--Siemens Healthineers Collaboration with CDC Will Define Threshold for Neutralizing Antibody Sufficient to Confer Immunity

COVID-19 Positivity Rate By Blood Type:

A AB Percent Significance:

B O
The reference population for this
study was 2,204,742 people.
Meaning that blood types B and O
1.64% seem to be less susceptible to the
1.5% virus.

Original Data Set From The American Society of Hematology--Reduced prevalence of SARS-CoV-2 infection in ABO blood group O

Percentage of Blood Types Requiring


Ventilation in The ICU
100
Quick Summarization:
80
84%
From the current data, we have, blood
60 types are showing to likely have some
61% impact on COVID-19. Without A antibodies it
40 is more likely for a person to catch the
virus and exhibit more severe symptoms.
20

0
A & AB B&O
Original Data Set From Healio--Blood type may be linked to risk for COVID-19 infection, likelihood of severe outcomes

Sources:
American Red Cross --Facts About Blood and Blood Types
Healio-- Blood type may be linked to risk for COVID-19 infection, likelihood of severe outcomes
American Society of Hematology-- Studies Offer New Evidence for Possible Link Between Blood Type and COVID-19 Susceptibility and Severity
American Society of Hematology: Blood Advances Ash Publications-- Reduced prevalence of SARS-CoV-2 infection in ABO blood group O
Jama Network-- Investigating Whether Blood Type Is Linked to COVID-19 Risk
Siemens Healthineers-- Siemens Healthineers Collaboration with CDC Will Define Threshold for Neutralizing Antibody Sufficient to Confer Immunity

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