You are on page 1of 1

Product Information Novel Kinase Inhibitors

for cell signaling & oncology research

Toll Free:
S1048 VX-680 (877)796-6397
-- USA and Canada only --
» Aurora
Fax:
+1-713-796-9816
Technical Data:
H Orders
M.Wt: 464.59 N N S
+1-713-922-4115
Formula: C23H28N8OS N N enquiry@selleckchem.com
N NH
Solubility: DMSO H
N
Purity: 99%
O Tech Support
N tech@selleckchem.com
Storage: at -20℃ 2 years
(chemistry support)
CAS No.: 639089-54-6 Synonyms: MK-0457, Tozasertib techbio@selleckchem.com
(bio support)

Biological Activity Web


VX-680 is the inhibitor of Aurora-A,-B,-C kinases with apparent inhibition constant values of www.selleckchem.com
0.6,18,4.6 nM respectively.VX-680 caused accumulation of cells with 4N DNA content and
potently inhibited the proliferation of a wide variety of tumor cell types with IC50 values ranging
from 15 to 113 nM.Vx-680 had no effect on the viability of noncycling primary human cells at
concentrations as high as 10uM. [1]

Selleck Overnight Delivery Service


References

[1] Marumoto T, Zhang D, Saya H. Nat Rev Cancer. 2005 Jan;5(1):42-50


[2] Adams RR, Carmena M, Earnshaw WC. Trends Cell Biol. 2001 Feb;11(2):49-54
Return Policy
[3] Sasai K et al. Cell Motil Cytoskeleton. 2004 Dec;59(4):249-63
Please inspect packages immediately upon
[4] Elizabeth A Harrington et al. Nature Medicine.2004,10:262-267 receipt and notify customer service within

3 days of delivery of any damage or

discrepancies.Our team will take quick and

appropriate action to correct any problem.


MSDS & CoA
Goods ordered in error can only be accepted

Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery,

are unopened,have been stored correctly and

are in good condition. Should you wish to

return any item(s), prior authorization must

Notes be received from our customer service team.

Returns accepted will be subject to a 30%

restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.

NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-

ments,please contact Selleck directly by


Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under info@selleckchem.com or
the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115.
storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and
your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt.
recommendations on the product data sheet.

© Copyright 2010 Selleck chemicals.