Introduccón Generalidades y epidemiología:241 Las infecciones respiratorias son la principal causa de morbilidad y mortalidad infantil, siendo responsable

de aproximadamente un 29% de los fallecimientos de niños menores de 5 años a nivel mundial ADDIN EN.CITE <EndNote><Cite><Author>Bryce</ Author><Year>2005</Year><RecNum>33</RecNum><record><rec-number>33</rec-number><r ef-type name="Journal Article">17</ref-type><contributors><authors><author>Bryce , J.</author><author>Boschi-Pinto, C.</author><author>Shibuya, K.</author><autho r>Black, R. E.</author></authors></contributors><auth-address>WHO, Geneva, Switz erland.</auth-address><titles><title>WHO estimates of the causes of death in chi ldren</title><secondary-title>Lancet</secondary-title></titles><periodical><full -title>Lancet</full-title></periodical><pages>1147-52</pages><volume>365</volume ><number>9465</number><keywords><keyword>Cause of Death</keyword><keyword>Child< /keyword><keyword>*Child Mortality</keyword><keyword>Child, Preschool</keyword>< keyword>Humans</keyword><keyword>*World Health Organization</keyword></keywords> <dates><year>2005</year><pub-dates><date>Mar 26-Apr 1</date></pub-dates></dates> <accession-num>15794969</accession-num><urls><related-urls><url>http://www.ncbi. nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;l ist_uids=15794969 </url></related-urls></urls></record></Cite><Cite><Author>Fern andez</Author><Year>2009</Year><RecNum>37</RecNum><record><rec-number>37</rec-nu mber><ref-type name="Journal Article">17</ref-type><contributors><authors><autho r>Fernandez, M. </author><author>Gonzalez, G.</author><author>Cuevas, A.</author ><author>Llerena, M.</author><author>Reyes, S.M.</author><author>Martinez, Niurk a</author></authors></contributors><titles><title>Neumonías adquiridas en la comun idad en cuidados intensivos pediátricos.</title><secondary-title>Revista cubana de medicina intensiva y emergencias.</secondary-title></titles><periodical><full-t itle>Revista cubana de medicina intensiva y emergencias.</full-title></periodica l><pages>1505-1517</pages><volume>8</volume><number>2</number><dates><year>2009< /year></dates><urls></urls></record></Cite><Cite><Author>Monto</Author><Year>199 3</Year><RecNum>32</RecNum><record><rec-number>32</rec-number><ref-type name="Jo urnal Article">17</ref-type><contributors><authors><author>Monto, A. S.</author> <author>Sullivan, K. M.</author></authors></contributors><auth-address>Departmen t of Epidemiology, School of Public Health, University of Michigan, Ann Arbor.</ auth-address><titles><title>Acute respiratory illness in the community. Frequenc y of illness and the agents involved</title><secondary-title>Epidemiol Infect</s econdary-title></titles><periodical><full-title>Epidemiol Infect</full-title></p eriodical><pages>145-60</pages><volume>110</volume><number>1</number><keywords>< keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Age Factors</keywor d><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Female</ke yword><keyword>Humans</keyword><keyword>Incidence</keyword><keyword>Infant</keyw ord><keyword>Influenza, Human/epidemiology</keyword><keyword>Male</keyword><keyw ord>Michigan/epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Respir atory Tract Infections/*epidemiology/microbiology</keyword><keyword>Seasons</key word><keyword>Seroepidemiologic Studies</keyword><keyword>Sex Factors</keyword>< keyword>Virus Diseases/*epidemiology/microbiology</keyword><keyword>Viruses/*iso lation &amp; purification</keyword></keywords><dates><year>1993</year><pub-dates ><date>Feb</date></pub-dates></dates><accession-num>8432318</accession-num><urls ><related-urls><url>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&a mp;db=PubMed&amp;dopt=Citation&amp;list_uids=8432318 </url></related-urls></urls ></record></Cite></EndNote>[5-7]. Se estima que el 90% de estas infecciones son ca usadas por agentes virales ADDIN EN.CITE <EndNote><Cite><Author>Henrickson</Auth or><Year>2004</Year><RecNum>31</RecNum><record><rec-number>31</rec-number><ref-t ype name="Journal Article">17</ref-type><contributors><authors><author>Henrickso n, K. J.</author><author>Hoover, S.</author><author>Kehl, K. S.</author><author> Hua, W.</author></authors></contributors><auth-address>Department of Pediatrics, Medical College of Wisconsin and Children&apos;s Hospital of Wisconsin, Milwauk ee, 53226, USA. kellyj@mcw.edu</auth-address><titles><title>National disease bur den of respiratory viruses detected in children by polymerase chain reaction</ti tle><secondary-title>Pediatr Infect Dis J</secondary-title></titles><periodical>

<full-title>Pediatr Infect Dis J</full-title></periodical><pages>S11-8</pages><v olume>23</volume><number>1 Suppl</number><keywords><keyword>Adolescent</keyword> <keyword>Age Distribution</keyword><keyword>Child</keyword><keyword>Child, Presc hool</keyword><keyword>Cohort Studies</keyword><keyword>Female</keyword><keyword >Hospitals, Pediatric</keyword><keyword>Humans</keyword><keyword>Incidence</keyw ord><keyword>Infant</keyword><keyword>Influenza, Human/diagnosis/*epidemiology</ keyword><keyword>Male</keyword><keyword>Orthomyxoviridae/*isolation &amp; purifi cation</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>Respiratory Tract Infections/epidemiology/*virology</keyword><keyword>Respirovirus/*isolati on &amp; purification</keyword><keyword>Respirovirus Infections/diagnosis/*epide miology</keyword><keyword>Retrospective Studies</keyword><keyword>Risk Assessmen t</keyword><keyword>Sex Distribution</keyword><keyword>United States/epidemiolog y</keyword></keywords><dates><year>2004</year><pub-dates><date>Jan</date></pub-d ates></dates><accession-num>14730265</accession-num><urls><related-urls><url>htt p://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=C itation&amp;list_uids=14730265 </url></related-urls></urls></record></Cite></End Note>[8], siendo el virus respiratorio sincicial (VRS) el responsable de aproximad amente un 40% de las mismas, constituyendo así el principal agente infeccioso. Alg unos de los restantes agentes virales son Rhinovirus (20%), Adenovirus (8%), Met apneumovirus humano (8%) influenza A y B (6%), Coronavirus (5%), Parainfluenza 1 -4 (4%), y Bocavirus humano (HBoV) (1,5 - 22,4%) ADDIN EN.CITE <EndNote><Cite><A uthor>Monto</Author><Year>1993</Year><RecNum>32</RecNum><record><rec-number>32</ rec-number><ref-type name="Journal Article">17</ref-type><contributors><authors> <author>Monto, A. S.</author><author>Sullivan, K. M.</author></authors></contrib utors><auth-address>Department of Epidemiology, School of Public Health, Univers ity of Michigan, Ann Arbor.</auth-address><titles><title>Acute respiratory illne ss in the community. Frequency of illness and the agents involved</title><second ary-title>Epidemiol Infect</secondary-title></titles><periodical><full-title>Epi demiol Infect</full-title></periodical><pages>145-60</pages><volume>110</volume> <number>1</number><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword ><keyword>Age Factors</keyword><keyword>Child</keyword><keyword>Child, Preschool </keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Incidence</ keyword><keyword>Infant</keyword><keyword>Influenza, Human/epidemiology</keyword ><keyword>Male</keyword><keyword>Michigan/epidemiology</keyword><keyword>Middle Aged</keyword><keyword>Respiratory Tract Infections/*epidemiology/microbiology</ keyword><keyword>Seasons</keyword><keyword>Seroepidemiologic Studies</keyword><k eyword>Sex Factors</keyword><keyword>Virus Diseases/*epidemiology/microbiology</ keyword><keyword>Viruses/*isolation &amp; purification</keyword></keywords><date s><year>1993</year><pub-dates><date>Feb</date></pub-dates></dates><accession-num >8432318</accession-num><urls><related-urls><url>http://www.ncbi.nlm.nih.gov/ent rez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=843231 8 </url></related-urls></urls></record></Cite><Cite><Author>Maffey</Author><Year >2008</Year><RecNum>30</RecNum><record><rec-number>30</rec-number><ref-type name ="Journal Article">17</ref-type><contributors><authors><author>Maffey, A. F.</au thor><author>Venialgo, C. M.</author><author>Barrero, P. R.</author><author>Fuse , V. A.</author><author>Marques Mde, L.</author><author>Saia, M.</author><author >Villalba, A.</author><author>Teper, A. M.</author><author>Mistchenko, A. S.</au thor></authors></contributors><auth-address>Centro Respiratorio, Hospital de Nin os Dr. Ricardo Gutierrez.</auth-address><titles><title>[New respiratory viruses in children 2 months to 3 years old with recurrent wheeze]</title><secondary-tit le>Arch Argent Pediatr</secondary-title></titles><periodical><full-title>Arch Ar gent Pediatr</full-title></periodical><pages>302-9</pages><volume>106</volume><n umber>4</number><keywords><keyword>Child, Preschool</keyword><keyword>Combined M odality Therapy</keyword><keyword>Cross-Sectional Studies</keyword><keyword>Huma ns</keyword><keyword>Infant</keyword><keyword>Orthomyxoviridae/*isolation &amp; purification</keyword><keyword>Peptides</keyword><keyword>Prospective Studies</k eyword><keyword>Recurrence</keyword><keyword>*Respiratory Sounds</keyword><keywo rd>Respiratory Syncytial Viruses/*isolation &amp; purification</keyword><keyword >Respiratory Tract Infections/*epidemiology/therapy/*virology</keyword><keyword> Rhinovirus/*isolation &amp; purification</keyword><keyword>Virus Diseases/*compl

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generando las p roteínas capsídicas VP1 y VP2 respectivamente.)</isbn>< urls><related-urls><url>http://www. T. 3091. que transcribe la proteína NP1. paper)</isbn><call-num>STEACIE Q R 360 V5125 2007 BOOK V. David M. A. Stockholm. Sto ckholm.</author></authors></contributo rs><titles><title>Fields&apos. Karolinska University Hospital. Sweden. hasta el momento se han determinado 5. Karolinska University Hospital.</auth or><author>Eriksson. Patrick R.se</auth-address><titles><title>Cloning of a human parvovirus by molecular s creening of respiratory tract samples</title><secondary-title>Proc Natl Acad Sci U S A</secondary-title></titles><periodical><full-title>Proc Natl Acad Sci U S A</full-title></periodical><pages>12891-6</pages><volume>102</volume><number>36< /number><keywords><keyword>Child. purification/physiology< /keyword><keyword>Phylogeny</keyword><keyword>Respiratory Tract Diseases/*virolo gy</keyword></keywords><dates><year>2005</year><pub-dates><date>Sep 6</date></pu b-dates></dates><accession-num>16118271</accession-num><urls><related-urls><url> http://www.0781760607 (alk. ORF) que incluye otro más pequeño en fase.</author></authors></contr ibutors><titles><title>Medical microbiology</title></titles><pages>x.gov/catdir/enhancements/fy0739/2007017896-d. M.STEAC-CIR C QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http://www.loc. Bernard N.CITE <EndNote><Cite><Author>Allander</A uthor><Year>2005</Year><RecNum>25</RecNum><record><rec-number>25</rec-number><re f-type name="Journal Article">17</ref-type><contributors><authors><author>Alland er. A.gov/catdir/toc/ecip0717/2007017896.</author><author>Andersson.loc.html </url></relat ed-urls></urls></record></Cite><Cite><Author>Murray</Author><Year>2002</Year><Re cNum>35</RecNum><record><rec-number>35</rec-number><ref-type name="Book">6</reftype><contributors><authors><author>Murray. M. virology</title></titles><pages>2 v. y otro pequ eño.nih. Viral</keyword><keyword>Huma ns</keyword><keyword>Incidence</keyword><keyword>Infant</keyword><keyword>Male</ keyword><keyword>Molecular Sequence Data</keyword><keyword>Nasopharynx/virology< /keyword><keyword>Parvovirus/*genetics/*isolation &amp.0470023864 (hbk.list_uids=16118271 </url></related-urls></urls></record></Cite></ EndNote>[16]. 31].)&#xD. A. 2&#xD. paper)&#xD.html</ url><url>http://www. Sweden.gov /catdir/toc/ecip072/2006032230.</author><author>Howley.</keyword></keywor ds><dates><year>2007</year></dates><pub-location>Philadelphia</pub-location><pub lisher>Wolters Kluwer Health/Lippincott Williams &amp. B .</author><author>Tammi. T.k.loc. M.</author><author>Eriksson.dop t=Citation&amp. Wilkins</publisher><isbn> 9780781760607 (alk. T.</author><author>Tiveljung-Lindell.)&#xD. T.allander@karolin ska.ncbi.</author></authors></contributors><auth-address>Department of Clinical Microbio logy.9780470023877 (pbk. 86 )</pages><edition>5th</edition><keywords><keyword>Virology. 826</pages ><edition>4th</edition><keywords><keyword>Medical microbiology. aunque resta por determinar la secuencia de las estructuras en horqu illas de los extremos del mismo ADDIN EN.</author><author >Bjerkner. Louis</pub-location><publi sher>Mosby</publisher><isbn>0323012132</isbn><call-num>CHECKEDOUT QR 46 M445 200 2</call-num><urls></urls></record></Cite><Cite><Author>Fields</Author><Year>2007 </Year><RecNum>36</RecNum><record><rec-number>36</rec-number><ref-type name="Boo k">6</ref-type><contributors><authors><author>Fields.</author></authors></contributors><authaddress>Department of Clinical Microbiology.</author><author >Knipe.html </url></related-urls></urls></record></Cite> </EndNote>[2.STEACIE QR 360 V5125 2007 BOOK V. A. Molecular </keyword><keyword>Female</keyword><keyword>Genome.nlm.</author><author>Andersson.0470023872 (pbk. tobias.gov/entrez/query.allander@karolinska. 1&#xD. Peter M.loc.html</url><u rl>http://www. (xix.db=PubMed&amp. M.299 nucleótidos del geno ma de HBoV.</author><author>Tammi. Su genoma tiene un marco de lectura abierto (en inglés open reading fr ame.fcgi?cmd=Retrieve&amp.</author><author>Bjerkner. B.se</auth-address><titles><title>Cloni ng of a human parvovirus by molecular screening of respiratory tract samples</ti tle><secondary-title>Proc Natl Acad Sci U S A</secondary-title></titles><periodi . hacia el extremo 3`. 3.)&#xD. que codifica la proteína NS1. hacia el extremo 5`. Preschool</keyword><keyword>Cloning. en el medio de los antes mencionados. a su vez tiene otros dos ORFs uno de ellos de gran tamaño.</author><author>Tiveljung-L indell. tobias.</keyword></keywo rds><dates><year>2002</year></dates><pub-location>St. CITE <EndNote><Cite><Author>Allander</Author><Year>2005</Year><RecNum>25</RecNum ><record><rec-number>25</rec-number><ref-type name="Journal Article">17</ref-typ e><contributors><authors><author>Allander.gov/catdir/enhancements/fy0739/2007017896-b. ADDIN EN.

</keyword><keyword>Virus diseases. Wilkins</publisher><isb n>9780781760607 (alk.)&#xD.</author></authors></contributors><titles><title>Medica l microbiology</title></titles><pages>x. que facilita la entrada del virus a la célula.</keyword> </keywords><dates><year>2007</year></dates><pub-location>Chichester. 16.STEACIE QR 360 V5125 2007 BOOK V.)</isbn><urls><related-urls><url>http://www.html < /url></related-urls></urls></record></Cite><Cite><Author>Fields</Author><Year>20 07</Year><RecNum>36</RecNum><record><rec-number>36</rec-number><ref-type name="B ook">6</ref-type><contributors><authors><author>Fields. NJ</pub-location><publisher>John Wiley &amp. html</url><url>http://www.9780470023877 (pbk. Sons</publisher><isbn>97804 70023860 (hbk. 826</pages><edition>4th</edition><keywo rds><keyword>Medical microbiology. 31].list_uids=16118271 </url>< /related-urls></urls></record></Cite><Cite><Author>Carter</Author><Year>2007</Ye ar><RecNum>34</RecNum><record><rec-number>34</rec-number><ref-type name="Book">6 </ref-type><contributors><authors><author>Carter. 358</pages><keywords><keyword> Virology.gov/catdir/enhancements/fy0739/2007017896-d.</author></authors></contribu tors><titles><title>Fields&apos. 3091 . John B. H oboken. England . mientras que en el extremo N-terminal de VP2 hay .</author><author>Howley.)&#xD.ncbi.dopt=Citation&amp. (xix.)&#xD. paper)</isbn><call-num>STEACIE QR 360 V5125 2007 BOOK V.loc.</keyword></keyw ords><dates><year>2007</year></dates><pub-location>Philadelphia</pub-location><p ublisher>Wolters Kluwer Health/Lippincott Williams &amp. 1&#xD.</author><auth or>Knipe.STEAC-C IRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http://www.</keyword><keyword>Viruses.0470023872 (p bk. 2 y 3) Transripción y replicación: Realizando un paralelismo entre HBoV y los restantes virus integrantes de la fam ilia parvoviridae se puede deducir algunas de las funciones de las proteínas de HB oV.nih. purification/physiology</keyword><keyword>Phylogeny</keyword><key word>Respiratory Tract Diseases/*virology</keyword></keywords><dates><year>2005< /year><pub-dates><date>Sep 6</date></pub-dates></dates><accession-num>16118271</ accession-num><urls><related-urls><url>http://www.loc. fcgi?cmd=Retrieve&amp.html</url><url>http://www.loc. virology</title></titles><pages>2 v. Además.gov/catdir/toc/ecip0717/20070 17896. Venetia A.0470023864 (hbk. David M.html </url></related-urls></urls></record></Cit e><Cite><Author>Murray</Author><Year>2002</Year><RecNum>35</RecNum><record><recnumber>35</rec-number><ref-type name="Book">6</ref-type><contributors><authors>< author>Murray. 3.loc.</keyword></keywords><dates><year>2002</year>< /dates><pub-location>St.gov/catdir/enhancements/fy0739/2007017896-b.cal><full-title>Proc Natl Acad Sci U S A</full-title></periodical><pages>12891-6 </pages><volume>102</volume><number>36</number><keywords><keyword>Child. Louis</pub-location><publisher>Mosby</publisher><isbn>0 323012132</isbn><call-num>CHECKEDOUT QR 46 M445 2002</call-num><urls></urls></re cord></Cite></EndNote>[2. Bernard N. 2&#xD.db=PubMed&amp. Prescho ol</keyword><keyword>Cloning. Peter M.nlm. Patrick R. paper)&#xD.0781760607 (alk.</author></authors></contributors><titles><title>Virology : princi ples and applications</title></titles><pages>xix. VP1 tiene un dominio fosfolipasa A2 dependiente de calcio.g ov/catdir/toc/ecip072/2006032230. Molecular</keyword><keyword>Female</keyword><keywo rd>Genome. 86 )</pages><edition>5th</edition><keywords><keyword>Virology. la proteína VP1 tiene una señal de localización nuc lear en su extremo N-terminal. (Fig. Viral</keyword><keyword>Humans</keyword><keyword>Incidence</keyword>< keyword>Infant</keyword><keyword>Male</keyword><keyword>Molecular Sequence Data< /keyword><keyword>Nasopharynx/virology</keyword><keyword>Parvovirus/*genetics/*i solation &amp. Como se indicó anteriormente las proteínas VP1 y VP2 conforman la cápside protéica del v irión.gov/entrez/query.</author><author>Saunde rs.

(xix.</keyword> </keywords><dates><year>2007</year></dates><pub-location>Chichester. Venetia A. En el citoplasma se une a los microtúbulos.</keyword></keyw ords><dates><year>2007</year></dates><pub-location>Philadelphia</pub-location><p ublisher>Wolters Kluwer Health/Lippincott Williams &amp. Bernard N. ADDIN EN.</author><author>Saunde rs.gov/catdir/toc/ecip0717/20070 17896. y el grupo OH del extrem o 3´ es utilizado por la polimerasa como cebador para pasar de ADN simple hebra a ADN doble hebra.STEACIE QR 360 V5125 2007 BOOK V.g ov/catdir/toc/ecip072/2006032230.html </url></related-urls></urls></record></Cit e></EndNote>[2. Sons</publisher><isbn>97804 70023860 (hbk. (xix. 2&#xD.</author><author>Howley.loc. 1&#xD.CITE <EndNote><Cite><Author>Fields</Author><Year>2007< /Year><RecNum>36</RecNum><record><rec-number>36</rec-number><ref-type name="Book ">6</ref-type><contributors><authors><author>Fields.una señal de exportación nuclear. paper)</isbn><call-num>STEACIE QR 360 V5125 2007 BOOK V.)&#xD. Una vez en el núcleo.html</url><url>http://www. paper)&#xD. NJ</pub-location><publisher>John Wiley &amp.</author><author> Knipe. html</url><url>http://www. y sus receptores son. 8 6 )</pages><edition>5th</edition><keywords><keyword>Virology. Peter M.</author><auth or>Knipe.</author><author>Howley. 3] Luego de un reconocimiento exitoso el virus es endocitado y liberado en el citop lasma. virology</title></titles><pages>2 v. es necesario que el virión sufra algunos cambios conformacionales para exponer la señal de localización nuclear.STEAC-CIRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http://www. John B. Para poder ingresar al núcleo. Bernard N. con la ayuda de la actividad fosfolipasa A2 de VP 1. virology</title></titles><pages>2 v. los cuales transportarán el virión haci a un poro nuclear. Wilkins</publisher><isb n>9780781760607 (alk.</keyword></keyword s><dates><year>2007</year></dates><pub-location>Philadelphia</pub-location><publ isher>Wolters Kluwer Health/Lippincott Williams &amp.loc. Las proteínas NS1 y NP1 son no estructurales.CITE <EndNote><Cite><Author>Carter</Author><Year>2007</Ye ar><RecNum>34</RecNum><record><rec-number>34</rec-number><ref-type name="Book">6 </ref-type><contributors><authors><author>Carter.CITE <EndNote><Cite><Author>Fields</Author><Year>2007< /Year><RecNum>36</RecNum><record><rec-number>36</rec-number><ref-type name="Book ">6</ref-type><contributors><authors><author>Fields.STEACIE QR 360 V5125 2007 BOOK V. 3091 .</author></authors></contributors><titles><title>Virology : princi ples and applications</title></titles><pages>xix.html </url></related-urls></urls></record></Cite>< /EndNote>[2] La externalización de las secuencias N-terminales tanto de VP1 como de VP2 parecería n ser importante para la entrada del virus a la célula. Los extremos del genoma viral son doble hebra debido al apareamiento de bases.gov/ catdir/toc/ecip072/2006032230. Wilkins</publisher><isbn>9 780781760607 (alk.0470023864 (hbk. H oboken. David M.0781760607 (alk. el ADN viral simple hebra es con vertido en doble hebra utilizando la maquinaria celular. England .)&#xD. Sin embargo se desconoce el rol que cumple NP1 dado que esta no se encuentra en los otros virus de esta familia. paper)&#xD. ADDIN EN.</author><author> . en la zona perinuclear. David M.loc.gov/catdir/enhancements/fy0739/2007017896-d. receptores de transferrina o el ácido siálico. 358</pages><keywords><keyword> Virology.</author></authors></contributor s><titles><title>Fields&apos. 2&#xD.html < /url></related-urls></urls></record></Cite><Cite><Author>Fields</Author><Year>20 07</Year><RecNum>36</RecNum><record><rec-number>36</rec-number><ref-type name="B ook">6</ref-type><contributors><authors><author>Fields. por ejemplo.</keyword><keyword>Virus diseases. ADDIN EN. Los virus de esta familia tienen como células blanco a las células eritroide s. Peter M. NS1est a implicada en la replicación y tiene actividad NTPasa y helicasa.STEAC-C IRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http://www. Bernard N. 86 )</pages><edition>5th</edition><keywords><keyword>Virology.loc.</keyword><keyword>Viruses. atravesando los poros nucleares. 1&#xD. paper)</isbn><call-num>STEACIE QR 360 V5125 2007 BOOK V.loc.)</isbn><urls><related-urls><url>http://www.</author></authors></contribu tors><titles><title>Fields&apos. 3091.0470023872 (p bk. la cual se da a través del r econocimiento del receptor en la membrana celular y la posterior endocitosis del virus. el antígeno P.)&#xD.0781760607 (alk.9780470023877 (pbk.gov/catdir/enhancements/fy0739/2007017896-b.

</author><author>Saunders.0781760607 (alk. Venetia A.gov/ catdir/toc/ecip072/2006032230. El mecanismo utiliz ado para la replicación se denomina rolling hairpin . 86 )</pages><edition>5th</edition><keywords><keyw ord>Virology.</author></authors></con tributors><titles><title>Virology : principles and applications</title></titles> <pages>xix. Los ARNm largo s transcriben las proteínas no estructurales. Venetia A. 3] La replicación se realiza utilizando la maquinaria celular. paper)&#xD. Sons</publisher><isbn>9780470023860 (hbk. incluyendo la ADN poli merasa.html</url><url>http://www. John B.loc.9780470023877 (pbk. 8 6 )</pages><edition>5th</edition><keywords><keyword>Virology.gov/catdir/enhancemen ts/fy0739/2007017896-d.</author></authors></contributors><ti tles><title>Virology : principles and applications</title></titles><pages>xix.</keyword><keyw ord>Virus diseases.html </url></relat ed-urls></urls></record></Cite></EndNote>[2. ADDIN EN. Hoboken.loc. mientras que los cortos las estructu rales. 1&#xD.</keyword><keyword>Viruses. 3] Para la transcripción el virus utiliza la ARN polimerasa II celular.gov/catdir/enha ncements/fy0739/2007017896-b. NJ</pub-location><publisher>Jo hn Wiley &amp. Peter M. virology</title></ titles><pages>2 v. 358</pages><keywords><keyword>Virology.go v/catdir/enhancements/fy0739/2007017896-b.)&#xD. paper)</isbn><call-num>STEACIE QR 360 V5125 2007 BOOK V.gov/catdir/toc/ecip072/2006032230. 3 58</pages><keywords><keyword>Virology.CITE <EndNote><Cite><Author> Carter</Author><Year>2007</Year><RecNum>34</RecNum><record><rec-number>34</rec-n umber><ref-type name="Book">6</ref-type><contributors><authors><author>Carter.html </url></related-urls></urls></record></Cite><Cite><A uthor>Fields</Author><Year>2007</Year><RecNum>36</RecNum><record><rec-number>36< /rec-number><ref-type name="Book">6</ref-type><contributors><authors><author>Fie lds.</keyword></keywords><dates><year>2007</year></dates><pub-loc ation>Chichester.</author><author>Saunders.0470023864 (hbk. gov/catdir/toc/ecip0717/2007017896.loc.0781760607 (alk. Peter M. Hoboken.)& #xD.</keyword></keyword s><dates><year>2007</year></dates><pub-location>Philadelphia</pub-location><publ isher>Wolters Kluwer Health/Lippincott Williams &amp.</author></authors></contributor s><titles><title>Fields&apos. 2&#xD.loc.STEAC-CIRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http://www. así como los fa ctores de transcripción celular.html</url><url>http://www.loc.loc.Knipe.0470023872 (pbk. Bernard N. Wilkins</publisher><isbn>9 780781760607 (alk.html </url></related-urls></urls></record></Cite>< Cite><Author>Carter</Author><Year>2007</Year><RecNum>34</RecNum><record><rec-num ber>34</rec-number><ref-type name="Book">6</ref-type><contributors><authors><aut hor>Carter.</author><author>Howley.)&#xD.)</isbn><urls><related-urls><url>ht tp://www. 3091.STEACIE QR 360 V51 25 2007 BOOK V. Wilkins</publisher><isbn>9780781760607 (alk.html</url><url>http://www. (xix.STEAC-CIRC QR 360 V5125 2007 CD-ROM</call-num><urls><relat ed-urls><url>http://www. England .978047002 3877 (pbk. NJ</pub-location><publisher>John Wiley &amp .html</url><url>http://www. al final del cual se obtiene un a sola molécula de ADN compuesta por varias copias del genoma viral unidas por sus extremos. En la figura 4 se esquematizan los pasos necesarios para la replicación rolling hair . David M. 2&#xD. p aper)</isbn><call-num>STEACIE QR 360 V5125 2007 BOOK V. (xix.)&#xD. England . alternando una copia de ADN de polaridad positiva y otra negativa.STEACIE QR 360 V5125 2007 BOOK V.</ keyword><keyword>Virus diseases.)&#xD. El transcripto primario sufre varios eventos de s plicing para producir dos tipos de ARNm: los largos y los cortos. 1&#xD. </author></authors></contributors><titles><title>Fields&apos. por lo que requiere que la celula este en la fase S.loc. paper)&#xD. Las proteínas no estructurales son fosforiladas y son las encargadas de co ntrolar la expresión y la replicación del ADN.html </url></related-urls></urls></record></ Cite></EndNote>[2. David M. J ohn B. 3091.</author><author>Howley.)</isbn><urls><related-urls><url>http://www.loc.0470023864 (hbk.0470023872 (pbk.)&#xD. Sons</publisher><isbn>9780470023860 (hbk.</keyword><keyword>Viruses.</author><author>Knipe.gov/catdir/toc/ecip0717/2007017896.</keyword></keywords><dates><year>2007</year></dates><pub-location> Philadelphia</pub-location><publisher>Wolters Kluwer Health/Lippincott Williams &amp.gov/catd ir/enhancements/fy0739/2007017896-d. virology</title></titles><pages>2 v.</keyword></keywords><dates><year>2007</year></d ates><pub-location>Chichester.

86 )</pages><edition>5th</edition><keywords><keyword>Virology. Bern ard N. Sons</p ublisher><isbn>9780470023860 (hbk. ADDIN EN. La polaridad del ADN encap sidado depende de cada virus. del estado de fosf orilación de las proteínas capsídicas ADDIN EN. John B. Wil kins</publisher><isbn>9780781760607 (alk. Peter M.gov/catdi r/toc/ecip0717/2007017896.</author></authors></contributors><titles><tit le>Virology : principles and applications</title></titles><pages>xix.)</isbn><urls><related-urls><url>http://www. Hoboken.)&#xD.CITE <EndNote><Cite><Author>Carter</A uthor><Year>2007</Year><RecNum>34</RecNum><record><rec-number>34</rec-number><re f-type name="Book">6</ref-type><contributors><authors><author>Carter.</ author><author>Knipe. paper)</is bn><call-num>STEACIE QR 360 V5125 2007 BOOK V. Bernard N.</keyword><keyword>Virus diseases. 358</pages ><keywords><keyword>Virology.loc.</keyword><keyword>Viruses. asegurándose de que solamente un a copia del mismo sea encapsidado. en parte.</keyword></keywords><dates><year>2007</year></dates><pub-location>Chi chester. NJ</pub-location><publisher>John Wiley &amp. 1&#xD. y la molécu la se pueda volver a replicarse para formar una estructura tetramérica lineal (pas os 8 y 9 de la figura 4). traslocado al citopl asma.loc.</author></author s></contributors><titles><title>Fields&apos. dependiendo.gov/catdir/enhancements/fy0739 /2007017896-d. En primer lugar se debe obtener el ADN doble hebra.</author><author>Howley.html</url><url>http://www. 86 )</pages><edition>5th</edition><keywords><keyword>Virol ogy.)&#xD. 3091.loc.html </url></related-urls></urls></record></Cite><Cite><Author>Fie lds</Author><Year>2007</Year><RecNum>36</RecNum><record><rec-number>36</rec-numb er><ref-type name="Book">6</ref-type><contributors><authors><author>Fields. de modo que se forma una estructura diméric a lineal (paso 7 de la figura 4).0781760607 (alk. paper)&#xD. luego de la elongación se une covalentemente el extremo 3´ con la horquilla del extremo 5´ (paso 2 de la figura 4) . England .</ke yword></keywords><dates><year>2007</year></dates><pub-location>Philadelphia</pub .</keyword></keywords><dates><year>2007</year></dates><pub-location>Philadelp hia</pub-location><publisher>Wolters Kluwer Health/Lippincott Williams &amp. Venetia A.</author> </authors></contributors><titles><title>Fields&apos. virology</title></titles><p ages>2 v.pin.STEAC-CIRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls>< url>http://www. y también sería la encargada del procesamiento proteolítico de la molécula de ADN.0470023872 (pbk.gov/catdir/toc/ecip072/2006032230.html</url><url>http://www.9780470023877 (pbk .gov/catdir/enhancements/ fy0739/2007017896-b.</author><author>Knipe. 3091. utilizando la horquilla del extremo 3´ como cebador (paso 1 de la figura 4). o transportado fuera de la célula. (xix. Una vez que el virión está ensamblado.loc. David M. donde se ensamblan y se encapsida el ADN. Peter M. Posteriormente la proteína NS1 mella la cadena 18 nt corriente abajo de donde se encontraba anteriormente el extremo 5´ (paso 3 de la figura 4) y el OH del extrem o 3´ sirve como cebador para rellenar el gap producido por el corte que realizó NS1 (paso 4 de la figura 4).STEACIE QR 360 V5125 2007 B OOK V. este puede ser retenido en el núcleo.</author><author>Howley. 2&#xD. algunos virus tienen preferencia por algún tipo de p olaridad. Luego los extremos 5´ y 3´ de la molécula doble line al se desnaturalizan para que ambos extremos puedan formar horquillas. Después los extremos 3´ y 5´ de la molécula doble hebra lineal se desnaturalizan para que ambos extremos puedan formar horquillas (paso 5 de l a figura 4) y el OH del extremo 3´ sirve como cebador para replicar nuevamente la molécula de ADN (paso 6 de la figura 4).)&#xD. 3] Las proteínas de la capside que fueron traducidas en el citoplasma son transportad as al núcleo. David M. (xix.html </url></related-urls>< /urls></record></Cite></EndNote>[2. mientras que otros encapsidan cerca de un 50% de cada uno. virology</title></titles><pages>2 v .</a uthor><author>Saunders.0470023864 (hbk.CITE <EndNote><Cite><Author>Fields</Aut hor><Year>2007</Year><RecNum>36</RecNum><record><rec-number>36</rec-number><reftype name="Book">6</ref-type><contributors><authors><author>Fields. Se cree que es NS1 la responsable de desenrollar la mo lécula de ADN a medida que se va encapsidando el genoma.

2 &#xD.nlm. C. X.</author><author>Endo.CITE <EndNote><Cite><Author>Ma</Author><Year>2006</Year><R ecNum>24</RecNum><record><rec-number>24</rec-number><ref-type name="Journal Arti cle">17</ref-type><contributors><authors><author>Ma. H.s Hospital.</author><author>Cui. purifica tion/pathogenicity</keyword><keyword>Respiratory Tract Infections/*virology</key word></keywords><dates><year>2006</year><pub-dates><date>Mar</date></pub-dates>< /dates><accession-num>16517912</accession-num><urls><related-urls><url>http://ww w.dopt=Citation&amp.db=PubMed&amp. Japan.</author><author>Shen.s Hospital</title><secondary-title>Chin Med J (Engl)</secondary-tit le></titles><periodical><full-title>Chin Med J (Engl)</full-title></periodical>< pages>1607-10</pages><volume>121</volume><number>17</number><keywords><keyword>B ocavirus/*isolation &amp. lograron aislar el virus a partir de un cultivo celul ar primario de epitelio pseudoestratificado de vías aéreas humanas (células bronqueo-t raqueales). purification</keyword><keyword>Child. W. J.gov/entrez/query. R.</author><author>Xu. T.nih. Y.list_uids=19024084 </url></related-urls></u rls></record></Cite></EndNote>[17.loc.</author><author>Xie. N. Hokkaido University Graduate School of Medicine.STEAC-CIRC QR 360 V5125 2007 CD-ROM</call-num><urls><related-urls><url>http ://www.. T. W-7. Capital Medical University.</author><author . Kita-ku. L. El la figura 5 se muestra un esquema del ciclo celula r de los parvovirus. L. L. K.list_uids=16517912 </url></related-urls></urls></record></Cite><Cite><Auth or>Zhang</Author><Year>2008</Year><RecNum>23</RecNum><record><rec-number>23</rec -number><ref-type name="Journal Article">17</ref-type><contributors><authors><au thor>Zhang. N-15. L. R. X.</author><author>Tang. Y. S.-location><publisher>Wolters Kluwer Health/Lippincott Williams &amp. A.</author></authors></co ntributors><auth-address>Department of Pediatrics.fcgi?cmd=Retrieve &amp. esto no se ha logrado.</author></authors></contributors>< auth-address>Virus Laboratory.</author><author>Li. 1&#xD. paper)&#xD. 32]. N.</author ><author>Ji.</author> <author>Xu. Beijing 100045. S. Sin embargo en los Países bajos Dijkman et al.</author><author>Ariga.CITE <EndNote><Cite><Author>Dijkman</Author><Year>2009</Yea r><RecNum>22</RecNum><record><rec-number>22</rec-number><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dijkman.dopt=Citatio n&amp. Viral/genetics</keyword><keyword>Female</keyword><keywor d>Humans</keyword><keyword>Infant</keyword><keyword>Japan</keyword><keyword>Male </keyword><keyword>Molecular Sequence Data</keyword><keyword>Parvoviridae Infect ions/*virology</keyword><keyword>Parvovirinae/genetics/*isolation &amp.ncbi.ncbi.</author><author>Kikuta.</auth-address>< titles><title>Detection of human bocavirus in Japanese children with lower respi ratory tract infections</title><secondary-title>J Clin Microbiol</secondary-titl e></titles><periodical><full-title>J Clin Microbiol</full-title></periodical><pa ges>1132-4</pages><volume>44</volume><number>3</number><keywords><keyword>Amino Acid Sequence</keyword><keyword>Base Sequence</keyword><keyword>Child.</author><author>Ebihara.</author><author>Ishiko . Aunque se han hecho esfuerzos por cultivar HBoV en líneas celulares como Vero.gov/catdir/toc/ecip072/2006032230. B. Z.nih. HEp -2 y LLC-MK2 ADDIN EN. Wilkins</pu blisher><isbn>9780781760607 (alk.nlm.html </url></related-urls></urls></ record></Cite></EndNote>[2].gov/entrez/query.0781760607 (alk. Preschool</keywo rd><keyword>Female</keyword><keyword>Humans</keyword><keyword>Infant</keyword><k eyword>Male</keyword><keyword>Parvoviridae Infections/*diagnosis/etiology</keywo rd><keyword>Polymerase Chain Reaction</keyword><keyword>Respiratory Tract Infect ions/*diagnosis/etiology</keyword></keywords><dates><year>2008</year><pub-dates> <date>Sep 5</date></pub-dates></dates><accession-num>19024084</accession-num><ur ls><related-urls><url>http://www.</author ><author>Tan. D. Y.db=PubMed&amp. ADDIN EN. H.</author><author>Mao. T. </author><author>Ishiguro. Beijing Children&apos.</auth-address><titles><title>Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing C hildren&apos. Preschool </keyword><keyword>DNA.STEACIE QR 360 V5125 2007 BOOK V. Sapporo 060-8638. paper)</isbn><call -num>STEACIE QR 360 V5125 2007 BOOK V. X. China.fcgi?cmd=Retrieve&amp. L.

Amsterdam.</author><author>Weissbrich. A. S. R. encontraron otro posible ORF a l que denominaron ORFx. The Netherlands. D-97078 Wurzburg. W. University Hospital A achen.</author><author>Schildgen. J.</author><author>Schubert.dopt=Citation&amp.</authaddress><titles><title>Real-time PCR for diagnosis of human bocavirus infections and phylogenetic analysis</title><secondary-title>J Clin Microbiol</secondary-t itle></titles><periodical><full-title>J Clin Microbiol</full-title></periodical> <pages>2116-22</pages><volume>45</volume><number>7</number><keywords><keyword>Bo cavirus/*genetics/*isolation &amp. S.gov/entrez/ query.</author></authors></contributors><auth-address >Division of Virology.ncbi. H.nlm.</au thor><author>Scheithauer. VP2.db=PubMed&amp.de</auth-address><titles><title>High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a st . que luego sufrirían splicing alternativo para llegar a los ARNm finales. Pauwelsstrasse 30.CITE <EndNote><Cite><Author>Neske</Author><Year>2007</Year>< RecNum>21</RecNum><record><rec-number>21</rec-number><ref-type name="Journal Art icle">17</ref-type><contributors><authors><author>Neske. el grupo de Dijkman e ncontró un solo promotor que sería responsable de la transcripción de todos los ARNm p rimarios. A través de un software que predice los posibles promotores.nih. Department of Medical Microbiology. L. F. K. NS1 y NP1. Analizando la secuencia genética encontraron que. no observ aron prácticamente ningún cambio morfológico entre las células infectadas con HBoV y las células control. M. RWTH Aachen.nlm.dopt=Citation&amp. O.</aut hor></authors></contributors><auth-address>Institute of Virology and Immunobiolo gy.>Koekkoek. purification/*physiology</keyword><keyword>Cells. M.</author><author>Kreth.</author><auth or>Rethwilm. University of Amster dam. K. Viral/classification/genetics</keyword><keyword>Humans</keyword>< keyword>Parvoviridae Infections/*diagnosis/*virology</keyword><keyword>*Phylogen y</keyword><keyword>Polymerase Chain Reaction/*methods</keyword><keyword>Reprodu cibility of Results</keyword><keyword>Respiratory Tract Diseases/virology</keywo rd><keyword>Time Factors</keyword><keyword>Viral Load</keyword></keywords><dates ><year>2007</year><pub-dates><date>Jul</date></pub-dates></dates><accession-num> 17475762</accession-num><urls><related-urls><url>http://www. 3).</author></authors></contributors><auth-address>Lab oratory of Experimental Virology.list_uids=174757 62 </url></related-urls></urls></record></Cite><Cite><Author>Kleines</Author><Ye ar>2007</Year><RecNum>20</RecNum><record><rec-number>20</rec-number><ref-type na me="Journal Article">17</ref-type><contributors><authors><author>Kleines. (Fig. M.</author><author>Tollmann. B.gov/ent rez/query.list_uids=19474096 < /url></related-urls></urls></record></Cite></EndNote>[4] Dijkman et al. purification</keyword><keyword>Child</keyword ><keyword>DNA. además de los ORFs ya conocidos de las proteínas VP1. Center for Infection and Immunity Amsterdam.</author><author>Rackowitz.db=PubMed&amp. F.</author><author>Bles sing.</auth-address><titles><title>Human bocavirus ca n be cultured in differentiated human airway epithelial cells</title><secondarytitle>J Virol</secondary-title></titles><periodical><full-title>J Virol</full-ti tle></periodical><pages>7739-48</pages><volume>83</volume><number>15</number><ke ywords><keyword>Base Sequence</keyword><keyword>Bocavirus/genetics/isolation &am p. D-52057 Aachen. Germany. mkleines@ukaache n. Infecciones por HBoV y respuesta inmune: En estudios de infecciones respiratorias la detección clínica de HBoV se realizó princ ipalmente en aspirados nasofaríngeos a través de una reacción en cadena de la polimera sa (PCR). También se realizaron experimentos de cuantificación de HBoV a través de rea l-time PCR ADDIN EN. 7.</author><author>Hausler.</author><author>Ritte r. A.</author><author>Molenkamp.ncbi. Academic Medical Center. Germany. Versbacher Str..nih.fcgi?cmd=Retrieve&amp. University of Wurzburg. Cultured</keyword><keyword> Epithelial Cells/*virology</keyword><keyword>Humans</keyword><keyword>Infant</ke yword><keyword>Molecular Sequence Data</keyword><keyword>Parvoviridae Infections /*virology</keyword><keyword>Respiratory System/*virology</keyword><keyword>Viru s Cultivation</keyword><keyword>Virus Replication</keyword></keywords><dates><ye ar>2009</year><pub-dates><date>Aug</date></pub-dates></dates><accession-num>1947 4096</accession-num><urls><related-urls><url>http://www.fcgi?cmd=Retrieve&amp. Department of Medical Microbiology.</au thor><author>van der Hoek.

Centers for Disease Control and Prevention.nlm.</author><author>Schub ert. I. pero en aquellos casos donde hubo una alta concentración viral en . N.</auth-address><titles><title>Real-time PCR for diagnosis of human bocavirus infections and phylogenetic analysis</title><secondary-title>J Clin M icrobiol</secondary-title></titles><periodical><full-title>J Clin Microbiol</ful l-title></periodical><pages>2116-22</pages><volume>45</volume><number>7</number> <keywords><keyword>Bocavirus/*genetics/*isolation &amp.ncbi.nih. M.dopt=Citation&amp.gov/entrez/quer y.l ist_uids=16954253 </url></related-urls></urls></record></Cite></EndNote>[33-35].</author><author>Erdman.db=PubMed&amp.gov/entrez/query. </author><author>Blessing. M. D-97078 Wurz burg. Germany.gov/entrez/query.</author ><author>Sloots. W.dopt=Citation &amp. A. X. purificat ion</keyword><keyword>Pneumonia. S. purification</keyword><keyword>Child.</author><author>Olsen. D. GA 30333. F.</author></authors></contributors><auth-address>Institute of Vir ology and Immunobiology. Viral/analysis</keyword><keyword>Humans</keywor d><keyword>Nucleocapsid Proteins/genetics</keyword><keyword>Parvoviridae Infecti ons/*virology</keyword><keyword>Parvovirinae/genetics/*isolation &amp. P.</author><author>Rethwilm. T. ADDIN EN.db=PubMed&amp. University of Wurzburg.nih. Viral/analysis</keyword><keyword>Humans</keyword><keyword>Infant</keyword><k eyword>Parvoviridae Infections/*epidemiology/virology</keyword><keyword>Polymera se Chain Reaction/*methods</keyword><keyword>Prevalence</keyword><keyword>Respir atory Tract Infections/*epidemiology/virology</keyword></keywords><dates><year>2 007</year><pub-dates><date>Mar</date></pub-dates></dates><accession-num>17215343 </accession-num><urls><related-urls><url>http://www. 7. y se intentó correlacionar las altas y bajas concentraciones virales con distintas sintomatologías clínicas.< /author></authors></contributors><auth-address>Respiratory and Gastroenteritis V iruses Branch. E. nlm. J. purification</keyword><k eyword>Child</keyword><keyword>DNA.db=PubMed&amp.</author><autho r>Weissbrich.</author><author>Tollmann.fcgi?cmd=Retrieve&amp.fcgi?cmd=Retrieve&amp. F. B.</author><author>Mackay.dopt=Citation&amp.list_uids=17475762 </url></related-urls></urls></record></Cite></EndNote>[33 ] Asimismo no se observó variaciones en la concentración viral en coinfecciones y en monoinfecciones. Versbacher Str.. Preschool</keyword><keyword>D NA. J.</auth-address><titles><title>Real-time PCR assays for detection of bocavirus in human specimens</title><secondary-titl e>J Clin Microbiol</secondary-title></titles><periodical><full-title>J Clin Micr obiol</full-title></periodical><pages>3231-5</pages><volume>44</volume><number>9 </number><keywords><keyword>DNA. H.ncbi. USA. A. Viral/classification/genetics</keyword><keyw ord>Humans</keyword><keyword>Parvoviridae Infections/*diagnosis/*virology</keywo rd><keyword>*Phylogeny</keyword><keyword>Polymerase Chain Reaction/*methods</key word><keyword>Reproducibility of Results</keyword><keyword>Respiratory Tract Dis eases/virology</keyword><keyword>Time Factors</keyword><keyword>Viral Load</keyw ord></keywords><dates><year>2007</year><pub-dates><date>Jul</date></pub-dates></ dates><accession-num>17475762</accession-num><urls><related-urls><url>http://www . 1600 Clifton Road. K.CITE <EndNote><Cite><Author>Neske</Auth or><Year>2007</Year><RecNum>21</RecNum><record><rec-number>21</rec-number><ref-t ype name="Journal Article">17</ref-type><contributors><authors><author>Neske. Mailstop G04. y aunque se encontró que en los casos de pacientes con neumo nía existían altos niveles de HBoV.</author><author>Fry.nih.nlm. Atlanta. D. el numero de muestras no permitió extraer conclusi ones estadísticamente aceptables.andard PCR protocol and a novel real-time PCR protocol</title><secondary-title>J Clin Microbiol</secondary-title></titles><periodical><full-title>J Clin Microbi ol</full-title></periodical><pages>1032-4</pages><volume>45</volume><number>3</n umber><keywords><keyword>Acute Disease</keyword><keyword>Bocavirus/genetics/*iso lation &amp.list_uids=17215343 </url ></related-urls></urls></record></Cite><Cite><Author>Lu</Author><Year>2006</Year ><RecNum>19</RecNum><record><rec-number>19</rec-number><ref-type name="Journal A rticle">17</ref-type><contributors><authors><author>Lu.fcgi?cmd=Retrieve&amp.</author><author>Chitt aganpitch. M. Viral/*virology</keyword><keyword>Polymerase Ch ain Reaction/*methods</keyword><keyword>Reproducibility of Results</keyword><key word>Sensitivity and Specificity</keyword><keyword>Taq Polymerase</keyword><keyw ord>Thailand</keyword><keyword>Viral Nonstructural Proteins/genetics</keyword></ keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates> <accession-num>16954253</accession-num><urls><related-urls><url>http://www.</author><author>Kreth.ncbi.

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Zhejiang. gov/entrez/query.CITE <EndNote><Cite><Author>Lin</Author><Year>2008</Year><RecNum>15</Re cNum><record><rec-number>15</rec-number><ref-type name="Journal Article">17</ref -type><contributors><authors><author>Lin.db=PubMed&amp.list_uids =19050360 </url></related-urls></urls></record></Cite></EndNote>[26. Bangkok. China.nlm. ADDIN EN. L. Viral/*blood/im munology</keyword><keyword>Bocavirus/*immunology/ultrastructure</keyword><keywor d>Capsid Proteins/*immunology</keyword><keyword>Child</keyword><keyword>Child. Transmission</keyword><keyw ord>Parvoviridae Infections/*epidemiology/immunology/virology</keyword><keyword> Respiratory Tract Infections/*epidemiology/immunology/virology</keyword><keyword >Seroepidemiologic Studies</keyword></keywords><dates><year>2008</year><pub-date s><date>Apr</date></pub-dates></dates><accession-num>18289709</accession-num><ur ls><related-urls><url>http://www. P reschool</keyword><keyword>China/epidemiology</keyword><keyword>Enzyme-Linked Im munosorbent Assay/*methods</keyword><keyword>Humans</keyword><keyword>Immunoglob ulin G/blood</keyword><keyword>Microscopy.</author><author>Yang. Y.db=PubMed&amp.list_uids=18217564 </url></relate d-urls></urls></record></Cite><Cite><Author>Chieochansin</Author><Year>2008</Yea r><RecNum>16</RecNum><record><rec-number>16</rec-number><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chieochansin.</author><author>Ishiguro.nlm.dopt=Citation&amp.</author><author>Pintel. R.</author><author>Guan. T. Department of Pediatrics. Electron.nih. H.nih.</author><author>Shirkoohi.</author></authors></contributors><auth-address>Wenling Hospital of W enzhou Medical College. R.db=PubMed&amp. C. J.fcgi?cm d=Retrieve&amp.</author><author>Poovorawan. DNA</keyword><keyword>Thailand/epidemiology</keyword></keywords ><dates><year>2008</year><pub-dates><date>Nov</date></pub-dates></dates><accessi on-num>19050360</accession-num><urls><related-urls><url>http://www.</auth-address><titles><title>ELISAs usi ng human bocavirus VP2 virus-like particles for detection of antibodies against HBoV</title><secondary-title>J Virol Methods</secondary-title></titles><periodic al><full-title>J Virol Methods</full-title></periodical><pages>110-7</pages><vol ume>149</volume><number>1</number><keywords><keyword>Antibodies.</author></authors></contributors><auth-address> Center of Excellence in Clinical Virology. A . Thailand.</author><a uthor>Cheng. 37]. lo cual permitiría concluir que HBoV no solo puede producir infecciones respiratorias. 36. sino que también sistémicas.dopt=Citation&amp. Faculty of Medicine.fcgi?cmd=Retrieve&amp. F.ncbi.gov/entrez/query.</author ><author>Kikuta. S. F. Chulalongkorn University. N.</author><author>Vimolket.word><keyword>Feces/virology</keyword><keyword>Female</keyword><keyword>Gastroen teritis/*virology</keyword><keyword>Humans</keyword><keyword>Infant</keyword><ke yword>Male</keyword><keyword>Parvoviridae Infections/complications/*virology</ke yword><keyword>Phylogeny</keyword><keyword>Polymerase Chain Reaction/methods</ke yword><keyword>Retrospective Studies</keyword></keywords><dates><year>2007</year ><pub-dates><date>Nov</date></pub-dates></dates><accession-num>18217564</accessi on-num><urls><related-urls><url>http://www.</auth-address><titles><ti tle>Human bocavirus infection in children with acute gastroenteritis and healthy controls</title><secondary-title>Jpn J Infect Dis</secondary-title></titles><pe riodical><full-title>Jpn J Infect Dis</full-title></periodical><pages>479-81</pa ges><volume>61</volume><number>6</number><keywords><keyword>Acute Disease</keywo rd><keyword>Animals</keyword><keyword>Bocavirus/classification/genetics/*isolati on &amp.ncbi. Los estudios serológicos realizados en sueros de niños y adultos han permitido detec tar Inmunoglobulinas anti-VP1 y anti-VP2 de HBoV.</ . D.gov/entrez/query. purification</keyword><keyword>Case-Control Studies</keyword><keyword>C hild.</author><author>Theamboonlers.</author><aut hor>Qiu. N.dopt=Citation&amp.fcgi?cmd=Retrieve &amp.</author><a uthor>Thongmee. Preschool</keyword><keyword>Feces/*virology</keyword><keyword>Female</keyw ord><keyword>*Gastroenteritis/epidemiology/virology</keyword><keyword>Hospitaliz ation</keyword><keyword>Humans</keyword><keyword>Infant</keyword><keyword>Molecu lar Sequence Data</keyword><keyword>*Parvoviridae Infections/epidemiology/virolo gy</keyword><keyword>Phylogeny</keyword><keyword>Prevalence</keyword><keyword>Se quence Analysis.list_uids=18289709 </url></related-urls></u rls></record></Cite><Cite><Author>Endo</Author><Year>2007</Year><RecNum>14</RecN um><record><rec-number>14</rec-number><ref-type name="Journal Article">17</ref-t ype><contributors><authors><author>Endo.nlm.nih. W.ncbi.</author><author>Teramoto.

</author><author>Endo.</author></authors></contributors><auth-address>Department of Pediatrics. X.nlm. purification</keyword><keyword>Humans</keyword><keyword>Infant</keyword><ke yword>Infant. N-15. T.db=PubMed&amp. H. W-7. N-15.</author><author>Ishiko. F.</au th-address><titles><title>ELISAs using human bocavirus VP2 virus-like particles for detection of antibodies against HBoV</title><secondary-title>J Virol Methods </secondary-title></titles><periodical><full-title>J Virol Methods</full-title>< /periodical><pages>110-7</pages><volume>149</volume><number>1</number><keywords> <keyword>Antibodies.</author></authors></contributors ><auth-address>Wenling Hospital of Wenzhou Medical College. Indirect/*methods</keyword><keyword>Human bocavirus/immunology/*isolation & amp.ncbi. Kita-ku. Preschool</keyword><keyword>China/epidemiolog y</keyword><keyword>Enzyme-Linked Immunosorbent Assay/*methods</keyword><keyword >Humans</keyword><keyword>Immunoglobulin G/blood</keyword><keyword>Microscopy. Hokkaido Univer sity Graduate School of Medicine.</author><author>Kikuta.</author><author>Qiu..gov/entrez/query.</auth-address><titles><title>Seroepidemiology of h uman bocavirus in Hokkaido prefecture. Sapporo 060-8638.</author><author>Cheng. W-7. T. En el trabajo de Lin et al. N. Huma n/immunology</keyword><keyword>Seroepidemiologic Studies</keyword><keyword>Spodo ptera</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></p ub-dates></dates><accession-num>17699639</accession-num><urls><related-urls><url >http://www. Sapporo 060-8638. R. Preschool</keyword><keyword>DNA. Viral/*blood</keyword><ke yword>Antibody Specificity</keyword><keyword>Blotting. H. N. Viral/blood</keyword><keyword>Fluo rescent Antibody Technique</keyword><keyword>Nasopharynx/virology</keyword><keyw ord>Parvoviridae Infections/*epidemiology</keyword><keyword>Parvovirus B19. D.</author><a uthor>Teramoto. Viral/*blood/immunology</keyword><keyword>Bocavirus/*immuno logy/ultrastructure</keyword><keyword>Capsid Proteins/*immunology</keyword><keyw ord>Child</keyword><keyword>Child. Viral/chemistry /genetics</keyword><keyword>Female</keyword><keyword>Fluorescent Antibody Techni que.</author><author>Ishiguro. Transmission</keyword><keyword>Parvoviridae Infections/*epidemiology/im munology/virology</keyword><keyword>Respiratory Tract Infections/*epidemiology/i mmunology/virology</keyword><keyword>Seroepidemiologic Studies</keyword></keywor ds><dates><year>2008</year><pub-dates><date>Apr</date></pub-dates></dates><acces .</au thor><author>Pintel.dopt=Citati on&amp.nih. F. Newborn</keyword><keyword>Male</keyword><keyword>Molecular Sequenc e Data</keyword><keyword>Parvoviridae Infections/*diagnosis</keyword><keyword>Se quence Analysis. S. W. Japan.author><author>Ma.</author><author>Ariga.</author><author>Ebihara. China.</au thor><author>Ariga.</author> </authors></contributors><auth-address>Department of Pediatrics. R.list_uids=17699639 </url></related-urls></urls></record></Cite>< Cite><Author>Shirkoohi</Author><RecNum>13</RecNum><record><rec-number>13</rec-nu mber><ref-type name="Journal Article">17</ref-type><contributors><authors><autho r>Shirkoohi. Viral/*blood</keyword><keyword>Antigens. Viral/*diagnostic use</keyword><keyword >Child</keyword><keyword>Child. T.ncbi.fcgi?cmd=Retrieve&amp. E lectron.nih.</author><author>Yang.nlm.gov/entrez/query.</ auth-address><titles><title>Antibodies against structural and nonstructural prot eins of human bocavirus in human sera</title><secondary-title>Clin Vaccine Immun ol</secondary-title></titles><periodical><full-title>Clin Vaccine Immunol</fulltitle></periodical><pages>190-3</pages><volume>17</volume><number>1</number><key words><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Antibodies. Western</keyword><keyword >Bocavirus/*immunology</keyword><keyword>DNA.fcgi?cmd=Retrieve&amp. Hokkaido University Graduate School of Medicine. Zhejiang. J. Japan</title><secondary-title>J Clin Micr obiol</secondary-title></titles><periodical><full-title>J Clin Microbiol</full-t itle></periodical><pages>3218-23</pages><volume>45</volume><number>10</number><k eywords><keyword>Animals</keyword><keyword>Antibodies. DNA</keyword><keyword>Viral Nonstructural Proteins/*diagnostic use</keyword><keyword>Viral Structural Proteins/*diagnostic use</keyword><keywor d>Young Adult</keyword></keywords><dates><pub-dates><date>Jan</date></pub-dates> </dates><accession-num>19955324</accession-num><urls><related-urls><url>http://w ww. ADDIN EN. Japan.do pt=Citation&amp. Kita -ku. </author><author>Guan.list_uids=19955324 </url></related-urls></urls></record></Cite></EndNote>[ 38-40].db=PubMed&amp.CITE <EndNote><Cite><Author>Lin</Au thor><Year>2008</Year><RecNum>15</RecNum><record><rec-number>15</rec-number><ref -type name="Journal Article">17</ref-type><contributors><authors><author>Lin.

mayor era la proporción de niños con sueros positivos para IgG anti-VP2 de HBoV. Kita-ku. H. los IgG anti-VP1 son más fácilmente detectables que los IgG anti-Vp2.fcgi?cmd=Retrieve&amp. Viral/*diagnostic use</keyword><keyword>Chi ld</keyword><keyword>Child.n cbi.</author><author>Ishiko.CITE <EndNote><Cite><Auth or>Endo</Author><Year>2007</Year><RecNum>14</RecNum><record><rec-number>14</recnumber><ref-type name="Journal Article">17</ref-type><contributors><authors><aut hor>Endo.</author><author>Kikuta. Western</keyword><keyword>Bocavirus/*immunology</keyword ><keyword>DNA.CITE <EndNote><Cite ><Author>Shirkoohi</Author><RecNum>13</RecNum><record><rec-number>13</rec-number ><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sh irkoohi. N. Vira l/*blood</keyword><keyword>Antigens. Esta diferencia puede deberse a que en los dos estudios u tilizaron anticuerpos para dos proteínas diferentes (VP1 y VP2).</author> </authors></contributors><auth-address>Department of Pediatrics.list_ui ds=18289709 </url></related-urls></urls></record></Cite></EndNote>[38] sueros de n iños de 0 a 9 años de edad fueron analizados para la detección de IgGs. Viral/chemistry/gen etics</keyword><keyword>Female</keyword><keyword>Fluorescent Antibody Technique.ncbi. N-15.dopt=Citation&a mp. Viral/blood</keyword><keyword>Fluorescent Antibody Technique</key word><keyword>Nasopharynx/virology</keyword><keyword>Parvoviridae Infections/*ep idemiology</keyword><keyword>Parvovirus B19. T. ADDIN EN. R. N. Kita-ku. Indirect/*methods</keyword><keyword>Human bocavirus/immunology/*isolation &amp.dopt=Citation&amp.</auth -address><titles><title>Antibodies against structural and nonstructural proteins of human bocavirus in human sera</title><secondary-title>Clin Vaccine Immunol</ secondary-title></titles><periodical><full-title>Clin Vaccine Immunol</full-titl e></periodical><pages>190-3</pages><volume>17</volume><number>1</number><keyword s><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Antibodies.</author><author>Endo.ncbi. N-15.db=PubMed&amp. Japan</title><secondary-title>J Clin Microbiol</secondary-title></titles ><periodical><full-title>J Clin Microbiol</full-title></periodical><pages>3218-2 3</pages><volume>45</volume><number>10</number><keywords><keyword>Animals</keywo rd><keyword>Antibodies. Japan.</author>< author>Ebihara.nih. DNA</keyword><keyword>Viral Nonstructural Proteins/*diagnostic use< /keyword><keyword>Viral Structural Proteins/*diagnostic use</keyword><keyword>Yo ung Adult</keyword></keywords><dates><pub-dates><date>Jan</date></pub-dates></da tes><accession-num>19955324</accession-num><urls><related-urls><url>http://www. W-7. S.</author><author>Ma. X.</author><au thor>Teramoto. y según se evidenci a en el trabajo realizado por el grupo de Shirkoohi ADDIN EN.gov/en trez/query. T.</author><autho r>Teramoto. También fue repor tado que los pacientes con aspirados nasofaríngeos positivos para HBoV.list_uids=17699 639 </url></related-urls></urls></record></Cite></EndNote>[39]también observaron est e aumento en el nivel de IgG en pacientes positivos para HBoV. Viral/*blood</keyword><keyword>Antibody Specificity</key word><keyword>Blotting. Hokkaido Univer sity Graduate School of Medicine.nlm.nlm. Japan.db=PubMed&amp. Sapporo 060-8638. W-7. R.dopt=Citation&amp.list_uids=19955324 </url></related-urls></urls></record></Cite></EndNote>[40].fcgi?cmd=Retrieve&amp. purification</keyword><keyword>Humans</keyword><keyword>Infant</keyword><keywor d>Infant. R. T.gov/entrez/query. Newborn</keyword><keyword>Male</keyword><keyword>Molecular Sequence Da ta</keyword><keyword>Parvoviridae Infections/*diagnosis</keyword><keyword>Sequen ce Analysis. . R. Human/immunology</keyword><keyword> Seroepidemiologic Studies</keyword><keyword>Spodoptera</keyword></keywords><date s><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><accession-num >17699639</accession-num><urls><related-urls><url>http://www.ni h. contenían un alto nivel de IgG en el suero . Hokkaido University Graduate School of Medicine. Preschool</keyword><keyword>DNA.</author><author>Ariga.</author><author>Ishiguro.. Sapporo 060-8638.</author><author>Kikuta.</author><author>Ariga. Se observó que a mayor edad.fcgi?cmd=Retrieve&amp.db=PubMed&amp.</author></au thors></contributors><auth-address>Department of Pediatrics. H.</author><author>Shirkoohi. sin embargo ellos encontraron que a la edad de 6 años el 100% de los pacientes eran positivos para IgG anti-VP1 de HBoV .nlm. S.nih. llegando a un 59% de sueros positivos en niños mayor de 3 años con infección respiratoria en las vías bajas y al 48% en niños sanos de 4 a 9 años.gov/entrez/query.sion-num>18289709</accession-num><urls><related-urls><url>http://www.</ auth-address><titles><title>Seroepidemiology of human bocavirus in Hokkaido pref ecture. H. Endo et al.</author><author>Ishiguro.

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