Name COCCI Staphylococc us aureus

Morphology

Weapons

Disease

Lab

Tx

Misc

Gram + grape facultative anaerobe, Catalase + Gray or golden yellow colonies Coagulase +, mannitol +, Novobiocin s, Yellow pigment + Beta Hemolysis + Some +Capsule/slime Superweapon/antigen 1. Exfoliative 2. TSST1 Cutaneous (acne etc),SSSS(bullous exfoliative dermatitis) TSS tampon Gastroenteritis(food poisoning) Endocarditis Bones, Joints Pneumonia,empyema Most common isolate in infections with artificial cardiac valves, prosthetic joints (THR) and CNS shunts Causes UTI in sexually active young females Smear Culture BAP Biochem Penicillin Cloxacillin Nafcillin Vancomycin Handwash and proper hygiene Can prevent disease

epidermidis

Gray to white, Coagulase -,M-,N s, Y-, H-

Aminoglycosi des etc.

Normal flora of skin, oppurtunistic

saprophyticus

Only one which is novobiocin resistant, Coagulase Streptococcus Gram +, in chains or pairs, catalase pneumonia Alpha Hemolytic, IgA protease colonization Optochin (S),bile Teichoic acid attachment Polysaccharide capsule soluble, lancet major, inhib phago shaped diplococcic Pneumolysin O damage found in URT respi epithelium (rusty sputum) viridians Alpha Hemolytic, Dextran (biofilm) Optochin (r), bile Growth in vegetation resistant (S. sanguis, (protects from immune) S. mutans, S. salivarius), normal

Bacterial pneumonia (most common on >65y/o) Adult meningitis (most common cause) Otitis media and sinusitis (most common in children) Septicemia Dental caries S. mutans Infective endocarditis

Pen-G

Prevented by pneumovacc.

Pen-G with aminoglycosi des for IE

Penicillin

Pyogenes (group A)

flora of human oropharynx Beta Hemolytic, Bacitracin (s), PYR +

Agalactiae (group B)

Enterococcus faecalis

Beta Hemolytic, Bacitracin (r), Hippuric acid, CAMP +, reservoir in human vagina, transmitted in child birth, PROM increases risk Gamma Hemolytic, 6.5%NaCl(+), group D Gamma Hemolytic,

Hyaluronic acid Capsule (antiphago) M CHON deadly virulence fx, used to type GABS M12 strain AGN Streptolysin O immunogenic Streptolysin S nonimmunogenic Streptokinase fibrin clot breakdown Stretococcal DNAse liq. Pus and extension of lesion Hyaluronidase spread in cellulitis Exotoxin A-C pyrogenic or erythrogenic, assoc to scarlet fever, activate Th cells and MHC class 2 Capsule Beta hemolysin CAMP fx

Acute/suppurative 1. Pharyngitis 2. Scarlet fever sandpaper rash, strawberry tongue, circumoral pallor, palms and soles spared 3. Pyoderma/Impetigo honey crusted lesions 4. Cellulitis/Necrotizing fasciitis flesh eating bacteria Non-suppurative sequalae 1. RF seq of Pharyngitis 2. AGN(m12 serotype) seq of cutaneous and pharyngitis Misc: puerperal fever, pneumonia, TSS like syndrome Neonatal Septicemia Meningitis

Rapid antigen test Throat swab ASO titer for RF (>200)

Pen-g DOC Erythro 2nd

Penicillin

Ampicillin Cefotaxime with genta

Treat mother prior to delivery

able to live in bowel, colon, UTI and Biliary tract urethra and gallbladder infections SBE through hematogenous due to bile/salt tolerance route

Vancomycin

Penicillin and gentamycin

bovis

cervicitis with purulent smear. for canal against antibody. complement (MAC) Capsular groups a and urethritis deficiencies. New York. discharge and intermenstrual Proceed to Chlamydia LOS endotoxin. Pharyngeal. catalase +. probe Disseminated gonococcal infection Colonizes Capsule. culture for Resistant to bleeding in females IgA1 protease. -Ferrin. of urethral Doxycycline contact and birth attach to eukaryotes. (PPNG) molecular Meningitis. does Bronchitis. Pneumonia. Martin Lewis. Rmp. Bprev by nonimuuno Rifampin and genic minoclycline Nomal flora. Ophthalmia neonatorum. IgA1 Meningitis Gram stain: Pen-G Vaccine: nd nasopharyx. LOS.Y and most common CA Waterhouse Friedrichsen acid prdxn Chloram w135 most syndrome (hemorrhage of 3rd gen Ceph: important to meningitis in adults with adrenals) Cefpeople with glu. respi polysacch: c cause droplet serogroup epidemics. Selective Media: Grows on Thayer Martin (Vancomycin. penicillin females. spore formers Clostridium Obligate anaerobe. Colistin and Nystatin). not utilize sinusitis. very sensitive to adverse env t and cold. gram . pneumonia. otitis media and carbohydrate(asacc conjunctivitis harolytic) B-lactamase (+) RODS Gram + bacilli.Neisserriae gonorrhea Meningitides Moraxella catarrhalis 6. Botulinum toxin heat Botulism floppy baby Clinical Polyvalent Proper . oxidase + Gram . acquired Pili attach. PID.mimicry.B. Genital Gonorrhea Gram stain Ceftriaxone + through sexual POR-antiphago.5%NaCl(-). group D Medium of Choice: BAP.mal humans. 2 protease Septicemia Culture: Alter: A. terminal spores botulinum Motile. B-lactamase Rectal. antiphago. arthritis.C. Opa symptomatic in males.

nonmotile. Metro-. otherwise add TIG difficile Reservoir is human colon. Penicillin. DC Toxins in antibiotics stool Bacillus anthracis Capsule polypeptide Anthrax toxin PA . systemic symptoms Culture double hemolysis on BAP Chopped meat gas Clinical Antitoxin (ABE) Amoxicillin Respiratory Support debridement Penicillin and clindamycin Debridement . invasive Zoonotic. papule & pustules. blocks release of Acth syndrome. from wool Toxin A enterotoxin damaging mucosa Toxin B cytotoxic Pseudomembranous colitis Endoscopy. double hemolysis Spores germinate in tissue Alpha toxin licithinase tissue destruction. for linear less than 6h old wounds vaccine only. Proper wound cleaning for prevention. tense tissue. antibiotic associated (clindamycin. TIG. Vaccine . diarrhea. dizziness. encapsulated. feces of horses and other animals Tetanospasmin blocks Glycine and GABA (inhib NTA) Tetanus trismus. soil. non-acidic and anaerobic (tae) labile. flaccid paralysis.entry. encapsulated. contaminated from soil or feces. cepha-. NV. opisthotonus Self-limiting infection for food poisoning so give supportive care DPT. zepam canning and no honey for infants tetani Motile. eye sx like blurring. flaccid paralysis. Doxy Autoclave. ampi). amox. risus sardonicus. weakness No GI symptoms for wounds Toxin in stool/seru m Perfringens Invasive. hepatic toxicity Enterotoxin Gas gangrene (myonecrosis) crepitus. localized. soil and human colon. non motile. LF(lethal) EF(edema) Anthrax eschar. Hyperbaric chamber Penicillin or Metro + Immune globulin for toxin. often with regional lymphadenopathy Culture and Serology Cipro.soil/dust/animal feces.

poor hygiene CNS. meningitis with septicemia in late onset due to fecal exposure Ampi and genta Food precaution meningitis Actinomyces israelii Renal transplants and Ca meningitis most commonly due to Listera meningitis Anaerobic. deli meats. endogenous transmission. helps organism escape or jump when cabbages. in tissues with low oxygenation Lumpy jaw dental trauma. non-spore formers Listeria Facultative intracellular. milk. Pelvic Microscopy or culture of sulfur granules Ampi or PenG and drainage . found in lysosome tries to dump non-pasteurized contents into phagosome. B-hemolytic Emetic toxin Diarrheal toxin meats. tumbling motility monocytogen Cold growth: soft Listeriolysin O B es cheeses. during immune delivery subtilis Listeriosis peaks in summer. very invasive but not painful. 18 hours) Lab contaminant Ground glass colonies Gram + Bacilli. branching rods.and animal hair cereus Motile. morile. Abdominal. across lethal to decreased placenta. hemolysin. non-encapsulated. symptomatic in pregnant women Neonates granulomatosis infantiseptica. gingival and female GT. sauces (cutaneous) Wool sorter s disease(pulmonary) GI(rare) Emetic diarrhea and vomiting (1-6 hours) diarrheal .coli like. thoracic. invasive Actinomycosis abscesses with sulfur granules. in utero early onset.watery diarrhea (e.

Nocardia asteroides Partially acid fast. Reservoir:RT. former non-chromogen(-dark/-light) and latter photochromogen(-dark/+light).way obstruction Membrane formation on infected wound that fails to heal Sulfonamid es or TMSZ PenG Gram stain Antitoxin + DPT <7y/o or PenG or TD >7y/o Methylene Erythro O antigen cross reactive Blue to nocardia and mycobac Culture (Loeffler Diptheria toxin inhib Slant. type specific. found in soil or dust. wounds. gravis. pigments). direct inoculation Corynebacteri Club shaped rods in um V or L shapes in diphtheriae tellurite medium. fibrin. mitis. 4 biotypes: belfanti.raised lesion violaceous color (+)pain and swelling K antigens heat labile. skin Nocardiosis bronchopulmonary but may spread to brain hematogenously Cutaneous from trauma. subcutaneous abscesses with granules(mycetoma) Erysipelod/sea finger/whale finger. airborne or trauma Erysipelothrix rhusopathiae Catalase. kasasii soil. animals scrofulaceum Scotochromogen(+dark/+light). fragment plate) B for transpo Elek plate test precipitin lines at zone of equivalence SCHICK test Mycobacteriu Acid fast. lysogenic C. Palisades or Chinese characters. diphtheria. soil. lymphadeno. major Diphtheriae toxin pseudomembrane(dead cells. found in surface waters. unique mycolic acid cell wall resistant to dessication and to many chemicals m avium & Potentially pathogenic. animals fortuitum and chelonae Rapid growers . intermedius. Chon synth by inactivating Tellurite EF-2. fragment A. land/sea animals. +H2S(black). a. oxidase and indole (-). sensitive to UV. found in surface waters.

paresthesia Lepromin Lepromatous weak cell test mediated immunity. leonine )lepromatou facies s RIPE 2 months intensive phase RI for 4 months maintenan ce phase -mycin injectables BCG to prevent Dapsone and Rifampin. add clofazamin e for lepromato us form Dapsone No cultures Gram negative bacilli Enterobactericeae all oxidase (-). cannot be grown in-vitro.gordonae. obligate intracellular. Escherichia and Shigella (SES). malachite green for selective growth. pneumoniae & oxytoca Enterobacter. organisms. most are motile except Shigella. Nasal course and low # of scrapings. EKE lactose fermenters KlebsiellaKlebsiella K. albumin to detoxify media. beningn Biopsy. rarely cause disease Sulfatides inhibits Tuberculosis phagosome-lysosome fusion Cord factor serpentine growth inhibiting leukocyte migration. transmitted via nasal discharge from lepromatous leprosy pt s Tuberculoid damage from immune response killing cells. organ affected NaOH decontam Naceylcysteine Leprae Cold lover. facultative anaerobes. doubling time is 18 hours Saprophytic. serologic tests useful to Salmonella. few macular Gram stain lesions. produces NIACIN. Klebsiella and Yersinia(SKY).pneumoniae(friedla lobar pneumonia with . damage done by immune system Microscopy sputum. fallax. disrupts mitochondria Tuberculin + mycolic acid cell mediated immunity. heat sensitive catalase. granuloma and loss of sensation Lepromatous nerve damage from bacterial overgrowth liquefaction Culture Chest X-ray PPD skin test 10mm+ Tuberculoid Strong cell Punch mediated immunity. all ferment glucose. gastri tuberculosis Auraminerhodamine staining(sensitive than Kinyoun or Nielsen). found in human skin or in armadillos. numerous (nodular lesions. (+)tuberculoi progressive course and high # d of organisms. flavescens.

rhinoscleromatis granulomatous disease of the nose K. P fimbriae. hemolysin. pulmo function K. mirabilis UTI and neonatal infections Neonatal meningitis K antigen UTI most common.g. K antigen currant jelly sputum. alcoholics and comp. non uropathogenic strains Citrobacter Escherichia coli Specimen as indicated by the localization of the disease process Antibacteri als e. granulomatis donovanosis(granuloma inguinale) Enterobacter UTI UTI alkalinazation of urine causing precipitation of Ca and Mg salts causing caliculi formation -damage to renal epithelium. high infective dose. most virulent Adhesins. most common is P. Providencia rettgeri.Serratia nder s bacillus) IMVC --++. heatstable toxins (STa and STb). heat labile (LT-I and LT-II). fimbrae. sulfonamid es. malabsorption and non . Exotoxins. mirabilis Morganella morgani. uncomplicated cystitis hemolysin Complicated pyelonephritis p. urease (+) with capsule Enterobacter IMVC -++. ozaenae chronic atopic rhinitis K. alkalifaciens Urease positive Most abundant aerobic flora of colon. index for fecal pollution of water. ampicillinm cephalospo rins. urease (-) no capsule Serratia marcescens with prodigiosin (red) Proteeae Proteus vulgaris. stuarti. fluoroquin olones and aminoglyco sides EPEC (pathogenic) Disruption of normal microvilli Infant diarrhea in underdeveloped countries.

infection usually localized to GIT.ETEC (toxigenic) EHEC (hemorrhagic ) Production of enterotoxin (heat stab and labile) leading to hyper secretion of fluids and electrolytes Production of shiga toxin (Stx 1 and Stx 2) leading to destruction of microvillus structure bloody diarrhea Travelers diarrhea in developed countries. No fever since no invasion. Rectal swab best Non-lactose fermenter Confirmed by serotyping Culture from Ceftriaxone Vaccine for . Shiga toxin enterotoxic. assay for shiga toxin. 0157:h7 is the most common. very low infective dose. bloody diarrhea (dysentery) Disease in underdeveloped countries. no leukocytosis in stool but (+) for RBC Do not use antibiotics. presents with fever Adherence of rods (stacked Infant diarrhea. low decreased fluid absorption grade fever and shortening of microvilli Invasive ulcerates Painful passage of bloody terminal ileum and colon. convulsions cytotoxic. dehydration. sorbitol (-) on McConkey agar. fever. TSI: K/A Fecal oral. watery diarrhea Grossly bloody diarrhea (hemorrhagic colitis) may lead to hemolytic uremic syndrome (HUS) with the use of antibiotics. least virulent. may develop HUS Thoroughly cooking ground beef EIEC (invasive) EAEC (aggregative) Shigella dysenteriaegrpA flexneri-grpB boydii-grpC sonnei-grpD Salmonella Does not infect animals. transmitted by 4f s. neurotoxic Invasion and destruction of epithelial cells lining the colon Enterocolitis typhimurum. travelers bricks) leading to diarrhea. mucoid stools with cramping rarely penetrates (dysentery). most Scanty. rehydrate only.

with H2S Yersinia pestis Safety pin appearance Facultative intracellular. most Flagellar H antigen Attach to microvilli -> cholera common bacteria in O1 antigen no capsule enterotoxin. 01 el tor . O139 antigen . positive for seeding Enteric fever typhoid and paratyphoid. typhi and paratyphi human. darkfield or phase Fluid and electrolyte replaceme nt Doxy or Tetra Furazol Increased susceptibility when decreased stomach acidity . oxidase (+) Vibrio. person to person or feces of animals Gram ( ) eubacteria with cell walls. Capylobacter. contagious iron blood/bone marrow is the best 1st-2nd week blood After 2nd stool/urine Widal Typhi Dot IgG and IgM Serologic or Cipro prevention IM polysacc capsule Oral live attenuated Strep with tetra Quarantine for 72 hours Animal control Killed vaccine Culture requires cold enrichment 1. does further typing watery stool -> hypovolemic not ferment gut only Septicemia occurs in chronic disease or pt with enterocolitis. endotoxin. rice round colonies. Envelope antigen (f-1) DIC and death Pneumonic plague inhibits phagocytosis PAI (pathogenecity island) . smooth inaba and hikojima for diarrhea 20-30L/day. transmitted by rodent flea bite(sylvatic plague). water and electrolytes -> Convex. not invasive -> surface waters. majority Yersioniosis. (intestineblood-intestine) Chronic carrier state: gallbladder Coagulase Bubonic plague flea bites. Two antigens (v and w) conjunctivitis. coagulase (+). mucinase. respi droplets enterocolitica Zoonotic. septicemia.enterica serotypes animal.inhalation. Endotoxin fever. regional buboes. found in rodents.similar to prolonged hypersecretion of polar flagellum. Helicobacter Vibrio cholera Alkaliphilic. TSI: K/A no gas. with ogawa. bloody diarrhea come from northern mimics appendicitis Europe (cold). Gram (-) comma shaped curved bacilli.

Culture green colonies 2. serology oxidase (+) 1.Oxidase (+) on BAP 1. some are halophilic transmitted personperson.arabinose. sucrose ()colonies for pregnant TMSZ children Endemic in India and SEA Pandemic in Africa Tetra DOC Campylobact er jejuni & coli Most common widespread causes of infection Gull wing shaped. gastroenteritis and bacterimia then death contrast 2.(+)VP and polymyxin(r) shock -> death parahaemolyt Halophilic. flies El tor -(+) hemolysin. oral ingestion. Microscopydarting motility Erythromyc in DOC Fluids and electrolyte s . Campy gray/colorles s with vancomycin. Butzler s. polymixin B and trimethopri m 2. motile with single flagellum. catalase (+). Slide agglutination using anti-O group 4.Culture 3. oxidase (+).Culture blue green. seafood icus (raw fish or shellfish) No enterotoxin Watery bloody diarrhea vulnificus Free-living. oysters Can cause severe wound infections.Culture Skirrow s. microaerophilic and thermophilic Lipopolysaccharides with endotoxic activity Some have extracellular and enterotoxins Multiply in SI->invades>inflammation-> blood in the stool Enteritis tissue invasion Resembles shigella Bacteremia -> enteric fever(typhoid) 1.

stool specimen. oxidase(+) DNase (+) <-aeromonas (-) Hemolysin. TMSZ Similar antigen with shigella sonnei diarrhea . urease (+).Biopsy 2. Serology Metro + Bismuth + Amox or tetra or clary + omeprazol e (MBAO) Deep in mucous layer Overlies gastric type Associated with PUD.Microscopy Giemsia or silver 4. N/V.Gastric Ulcer.Skirrow&C AP colorless 3. Gentamyci n. H2S(+) fetus S-Chon forms a capsule like structure on organism structure preventing phagocytosis Protease modifies gastric mucus Urease buffers acids Toxins and LPS damages cells Diarrhea.3. large zone of hemolysis. facultative anaerobic. fever. Amikacin.Urea breath test 7.antigen test(stool specimen) 6. oxidase (+). non-halophilic Gram (-) rod with polar flagellum. AdenoCA of stomach. caviae. catalase (+) 1. organism enters through GI . multiple flagella at one pole. colonization may persist for years or lifetime Helicobacter pylori Spiral shaped. Serum Ab 5. MALT B-cell lymphomas Aeromonas hydrophilia. tropical or subtropical areas. from freshwater fish and anials. urease(+). some with enterotoxin Gastroenteritis and wound infection (with or without bacteremia) Cipro. can cause bacteremia and systemic infections in IC patients PUD crampy abdominal pain. veronii biovar sobria Plesiomonas shigelloides Fresh and brackish water.

mucoid colonies inflamm. monas motile lopotrichous maltophilia Lavender green or gray O-F (glucose. contam skin infection Pneumonia when inhaled Tetra. Breach of barriers. LPS aeruginosa sweet/taco odor. oxidase (+) Pseudomonas Obligate aerobe.Gram (-) bacilli non-fermentative. non-pigmented. colistin + media. 6mo-1yr Tetra + aminoglyco side Use of indwelling plastic IV catheters Human bites Ampicillin . oxygen radicals alginate capsule. most media. wound (ecthyma gangrenosum). lopotrichous mallei Small. non-motile. Pyocyanin impair ciliary function. swimmer s ear. Chloram at least 8 weeks. TMSZ. disease of horses. maltose) Uncommon Gram (-) bacteria Eiknella Non-fermentative. compromised defense mechanisms Nosocomial. wrinkled colony. CF patients vulnerable Stenotropho Oxidase negative. tissue damage Cytotoxin(leukocidin) Burkholderia Bipolar safety-pin pseudomallei staining on meth blue or wright stain. pili. contact lens. tissue damage. ingestion. (endotoxic). Exotoxin A Chon motile with single synthesis. cystic fibrosis Combinatio n of Antibiotics Aminoglyc oside + B lactam Meliodosis pulmonary infection similar to TB MOT inhalation. mules and donkeys cepacia Grows in environment. Capsule. burns. polar flagella immunosuppressive Exotoxin S Chon synthesis.

apple or fruity odor Moraxella Oxidase(+) catalase (+) Non-motile. diarrhea Blepharoconjunctivitis Neonatal meningitis SBE (HACEK group) . Yellow colonies Meningosepti cum Kingela Hemolytic. gram()rods. wound. pits agar. normal oral flora Parvobacteria . non fermentative. diarrhea UTI. nonmotile. catalase(+).Small gram(-) bacteria and sulbactam UTI. assacharolytic. small fastidious capnophilic. wound.corrodens oxidase+. mistaken as Neisseria. normal flora of the gingival crevices and bowels in 40-70% of humans Acinetobacter Oxidase(-). MacConkey (-) mistaken as Neisseria Chryseobac. iwoffi (non-oxidizer) anitratus (oxidizer) Alkaligenes Oxidase(+) catalase faecalis (+) peritrichous flagella. asacchorylitic.

leukocytosis Paroxysmal 2-4 weeks medium Regan Tracheal cytotoxin whoop. chancroid. V(-) on CAP Polysaccharide capsule type b capsule is polyribitol phosphate.c. increases histamine Silent copy of pertussis similar toxin RT of dogs Chronic RTI DNA probe/cultur e Ceft.b. failure to produce indole and ferment xylose Growth: X(+). edema and impaired highest for culture direct cough plate. cough. a. secondary lymphocytosis. Co-tri. smokers Epiglottitis.c. open lesions increase transmission of HIV Small. most important virulence fx IgA protease mucosal colonizing fx Meningitis HIB Otitis media NTHI Bronchitis Pneumonia infants. complications hypoglycemia(insulin).d.Haemophilus influenza aegypticus ducreyi Capsulated: group 1 (a.d.major causative agents in unvaccinated toddlers Purulent conjunctivitis Brazilian purpuric fever Antigen screen on CSF latex particle agglutination Ceph + Rifampin if still colonized Actively prevented by conjugate capsular polysacch Chon vaccine Passive by Ig Sulfonamid es Bordetella pertussis parapertussis bronchiseptic STD. slow to heal without treatment. Adenylate cyclase toxin Catarrhal 1-2 weeks flu-like. encapsulated. Mucosal surface pathogen Pertussis (whooping cough) source of culture Filamentous hemagglutinin Incubation . epolysaccharide. gram(-).f) Unencapsulated: group 2 (NTHI) satellite phenomenon with S. lowe impairs cilia leukocytosis Pertussis toxin ADP Convalescence diminished ribosylation of G. non-motile. aureus Requires X&V on CAP Koch-weeks bacillus. human pathogen only Fastidious growth. biotype III.7-10 days saline nasal wash. vomiting. Erythro Blood count: Supportive lymphocytosi Erythro s Direct immunofluor escence naso swab PCR .e.f teichoic acid . strict aerobes.

flulike. sexually transmitted. streptomyc in. pasteurize milk SPIROCHETES Treponema pallidum pallidum OMP adherence Hyaluronidase perivascular infiltration Fibronectin coatphagocytosis Immune response tissue destruction Syphilis Darkfield. facultative intracellular. sweating. facultative intracellular.a Pasteurella multocida Francisella tularensis Brucella Small. erythro. genta. bipolar staining. transmitted via bites Gram(-). Facultative intracellular in RES. bioterrorism Thin. ocular complications serological Teta. chloram . gram(-). found in dog and cat mouths. tetracyclin e. oropharyngeal. Direct fluorescence Nontreponemal tests: VDRL. domestic. hepatomegaly Undulant milder. facultative anaerobe. malta fever) Acute septicemia fever. RPR PenG. skinning rabbitsulceroglandular disease. aerobic. aerosols pneumonia. granulomatous response Brucellosis(undulant fever. granulomatous response Syndromes of Tularemia Ulceroglandular. encapsulated. birth canal. helical. pneumonic. ampicillin. zoonotic. glandular. ingestion of meat typhoidal Gram(-). gram(-) Humans only host. contaminated blood Endotoxin. dairy products. oculogladndular. typhoidal serological PenG Amox/clav u for most bites as prophylaxis and tx Strep or Avoidance Genta and Tetra immunization B-lactam resistant Endotoxin. wild animals. capsule Cellulitis with lymhadenitis Rarely cultured Facultative intracellular in RES. incomplete tx Chronic depression and sweating. catalase(+). oxidase(+). rifampin Vaccinate animals.

erythro. oral lesions. Erythro Lyme disease rodent. Relapsing fever giemsa/wrig Doxy (epidemic/louse born) jarischht stain human reservoir. disease. erythro. twisting motility. Rodent. hard /ELISA. hard shelled tick to confirm ELISA vector +treponemal tests . MHA-TP Bejel (endemic syphilis) + VDRL. chloram Yaws/Pinta small pruritic Darkfield PenG.tick reservoir. shelled tick. erythro. destructive lesions +treponemal tetracyclin on skin. PenG. papules on the skin surface microscopy tetracyclin e. papules and +treponemal tetracyclin mucosal patches tests e.pallidum endemicum Use of contaminated eating utensils pallidum pertenue carateum Direct contact with infected lesion Borrelia Gram(-) with periplasmic cylinder and outer envelope. domestic pet western blot reservoir. late: gumma chloram Yaws granulomatous + VDRL. that enlarge and present for Serologic chloram months or years test late infection + VDRL. LN and bones tests e. body louse during herxheimer rxn vector febrile Relapsing fever (endemic/tick period born) Lyme disease Lyme Doxy. soft shelled tick vector Immunofluor Amox. PenG. +treponemal tests Borreliosis: RF RF: Tetra. microaerophilic Bite from arthropods Treponemal Tests: FTAABS.

corneal direct IF. rash. peptidoglycan layer no muramic acid.chronic follicular Iodine stain Eythro. prevents phago-lyso fusion infiltrates Neonatal conjunctivitis (dPCR K).Ba. follicular conjunctivitis.Leptospira interrogans and biflexia Thin coiled with hook at one or both ends. Probe. purulent discharge. hemorrhage.B. conjunctival suffusion. myocarditis -VDRL Culture through Fletcher s Blood. keratitis.Ba. divide by binary fission trachomatis Iodine staining.C. uveitis. D-K Culture le UG tract to chronic corneal abrasion most LGV L1.L2a. from birth canal. Doxy Doxy to prevent Chlamydiaceae and Mycoplasmataceae Smallest and simplest forms Chlamydia Obligate intracellular energy parasites gram(-). may lead to .B. with an elementary body(infectious form) and reticulate body(reproductive form).. urine -3-7 days septicemic with body pains.C A. blindness due Sulfisoxazo sulfonamides infects conjunctiva. fever Weil s disease(icteric) no leptospires in CSF -3-7 days similar 10-30 days immune stage with jaundice. Intracellular replication ELISA.L3 A-C and D-K. Two human biovars: Chlamydia trachomatis Cytology Tetra. Susceptible to Trachoma A. adult or acute specific. renal failure. inguinal lymph nodes McCoy preceded by genital infection medium (lymphogranuloma with mucopurulent Ag detection venereum) discharge.L2. fever -0-1 month immune stage with meningitis.1st week CSF 2nd week Urine after 1st week Serology only after 2 weeks but sensitive and specific peaks after 5-6 weeks Tetra. conjunctivitis. csf. entry through break in the skin in urine-contam water Anicteric Leptospirosis leptospires present in blood.

only invades mucous . menigismus. most common in adults. atypical CF. sinusitis. Erythro urine or respi secretions pneumonia TWAR agent (TWTetra and 183 and AR-39) erythro lethal species of psittaci or Taiwan acute respiratory agent. may lead to atherosclerosis Chlamydophil Inhalation of dried Tetra and a psittaci bird excrement. chills. GIT Bronchitis. MIF pneumonia. bronchitis Mycoplasmataceae Smallest and simplest of self replicating prokaryotes. Secondary stage Inguinal LN most often involved. anorexia Untreated elephantiasis Psittacosis(parrot fever). Ornithosis MIF Atypical pneumonia. dual infection with gonorrhea. heals rapidly. fever. associated with Reiters syndrome LGV primary lesion papule or ulcer often overlooked. CNS involvement is common. Serology: CF. polymorphic (lack cell wall) requires cholesterol for growth. painful Buboes Systemic body pains.pneumonia with distinct staccato sound. afebrile UG infection. females asymptomatic. human pathogen. males most common case of non gonococcal infection.

ELISA. CMV Tetra and erythro genitalum and U.urealyticu m hominis NGU Urealyticum resistant to tetra Resistant to erythromycin Pyelonephritis.membrane. cold agglutinins but non specific (+) in other diseases EBV. PID. postpartum fever .attaches to respi 15y/o worldwide. fried egg appearance of colonies pneumoniae Mulberry shaped P1 adhesion Chon colonies. epithelium inhalation of respi droplets Mild URTI Severe LRTI tracheobronchitis and atypical pneumonia(walking pneumonia) CF. children 5.